CodeW92
Name(1R,4R,5S,6R)-4-azanyl-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
Synonyms
Identifier
FormulaC7 H9 N O5
Molecular Weight187.15
SMILES
PubChem99643104
Formal Charge0
Total Atoms22
Total Chiral Atoms4
Total Bonds23
Total Aromatic Bonds0
Networks2
 missing image

This ligand is also present in the following 2 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8TQB C Aminoacid Metabotropic Glutamate mGlu3; mGlu3 Rattus Norvegicus Ca; PAM VU6023326 Ca - 3.3 2024-07-31 10.1101/2023.08.13.552748

A 2D representation of the interactions of W92 in 8TQB
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:R64 11.43 1 Yes Yes 0 5 0 1
L:L:?1 R:R:R68 8.16 1 Yes Yes 0 5 0 1
L:L:?1 R:R:S149 4.04 1 Yes Yes 0 5 0 1
L:L:?1 R:R:Y150 7.09 1 Yes Yes 0 4 0 1
L:L:?1 R:R:S151 6.05 1 Yes No 0 8 0 1
L:L:?1 R:R:T174 4.95 1 Yes No 0 8 0 1
L:L:?1 R:R:Y222 25.21 1 Yes Yes 0 7 0 1
L:L:?1 R:R:D301 5.47 1 Yes Yes 0 8 0 1
L:L:?1 R:R:G302 4.6 1 Yes No 0 6 0 1
L:L:?1 R:R:K389 10.42 1 Yes Yes 0 4 0 1
R:R:P46 R:R:S149 7.13 1 Yes Yes 5 5 2 1
R:R:P46 R:R:Y150 4.17 1 Yes Yes 5 4 2 1
R:R:P46 W:W:?3 9.06 1 Yes Yes 5 0 2 2
R:R:R64 R:R:R68 11.73 1 Yes Yes 5 5 1 1
R:R:Q306 R:R:R64 22.2 0 Yes Yes 4 5 2 1
R:R:E387 R:R:R64 12.79 1 No Yes 6 5 2 1
R:R:R68 R:R:S149 6.59 1 Yes Yes 5 5 1 1
R:R:R68 R:R:Y171 4.12 1 Yes Yes 5 7 1 2
R:R:A172 R:R:R68 4.15 1 No Yes 5 5 2 1
R:R:E387 R:R:R68 16.28 1 No Yes 6 5 2 1
R:R:K389 R:R:R68 7.43 1 Yes Yes 4 5 1 1
R:R:S100 R:R:Y150 8.9 0 No Yes 3 4 2 1
R:R:S149 R:R:Y171 6.36 1 Yes Yes 5 7 1 2
R:R:R277 R:R:Y150 19.55 1 Yes Yes 5 4 2 1
R:R:Y150 W:W:?2 4.31 1 Yes No 4 0 1 2
R:R:Y150 W:W:?3 4.31 1 Yes Yes 4 0 1 2
R:R:S151 R:R:S175 4.89 1 No No 8 7 1 2
R:R:S151 R:R:Y222 5.09 1 No Yes 8 7 1 1
R:R:A172 R:R:Y171 5.34 1 No Yes 5 7 2 2
R:R:A172 R:R:K389 4.82 1 No Yes 5 4 2 1
R:R:D194 R:R:T174 8.67 1 Yes No 8 8 2 1
R:R:D301 R:R:T174 7.23 1 Yes No 8 8 1 1
R:R:D194 R:R:Q197 9.14 1 Yes Yes 8 9 2 2
R:R:D194 R:R:Y222 8.05 1 Yes Yes 8 7 2 1
R:R:D194 R:R:F275 7.17 1 Yes Yes 8 7 2 2
R:R:F275 R:R:Q197 7.03 1 Yes Yes 7 9 2 2
R:R:Q197 R:R:S300 4.33 1 Yes No 9 8 2 2
R:R:D301 R:R:Q197 11.75 1 Yes Yes 8 9 1 2
R:R:F275 R:R:Y222 6.19 1 Yes Yes 7 7 2 1
R:R:S300 R:R:Y222 6.36 1 No Yes 8 7 2 1
R:R:D301 R:R:Y222 12.64 1 Yes Yes 8 7 1 1
R:R:G302 R:R:Y222 4.35 1 No Yes 6 7 1 1
R:R:F275 R:R:S300 9.25 1 Yes No 7 8 2 2
R:R:R277 W:W:?2 8.93 1 Yes No 5 0 2 2
R:R:D301 R:R:L325 4.07 1 Yes No 8 5 1 2
R:R:D301 R:R:K389 6.91 1 Yes Yes 8 4 1 1
R:R:E324 R:R:K389 4.05 0 Yes Yes 5 4 2 1
R:R:E387 R:R:K389 6.75 1 No Yes 6 4 2 1
R:R:F392 R:R:K389 3.72 1 Yes Yes 7 4 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.74
Average Nodes In Shell28.00
Average Hubs In Shell18.00
Average Links In Shell49.00
Average Links Mediated by Hubs In Shell48.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of W92 in 8TQB
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
M:M:?1 S:S:R64 11.43 4 Yes Yes 0 5 0 1
M:M:?1 S:S:R68 8.16 4 Yes Yes 0 5 0 1
M:M:?1 S:S:S149 4.04 4 Yes Yes 0 5 0 1
M:M:?1 S:S:Y150 7.09 4 Yes Yes 0 4 0 1
M:M:?1 S:S:S151 6.05 4 Yes No 0 8 0 1
M:M:?1 S:S:T174 4.95 4 Yes No 0 8 0 1
M:M:?1 S:S:Y222 25.21 4 Yes Yes 0 7 0 1
M:M:?1 S:S:D301 5.47 4 Yes Yes 0 8 0 1
M:M:?1 S:S:G302 4.6 4 Yes No 0 6 0 1
M:M:?1 S:S:K389 10.42 4 Yes Yes 0 4 0 1
S:S:P46 S:S:S149 7.13 4 Yes Yes 5 5 2 1
S:S:P46 S:S:Y150 4.17 4 Yes Yes 5 4 2 1
S:S:P46 X:X:?3 9.06 4 Yes Yes 5 0 2 2
S:S:R64 S:S:R68 11.73 4 Yes Yes 5 5 1 1
S:S:Q306 S:S:R64 22.2 0 Yes Yes 4 5 2 1
S:S:E387 S:S:R64 12.79 4 No Yes 6 5 2 1
S:S:R68 S:S:S149 6.59 4 Yes Yes 5 5 1 1
S:S:R68 S:S:Y171 4.12 4 Yes Yes 5 7 1 2
S:S:A172 S:S:R68 4.15 4 No Yes 5 5 2 1
S:S:E387 S:S:R68 16.28 4 No Yes 6 5 2 1
S:S:K389 S:S:R68 7.43 4 Yes Yes 4 5 1 1
S:S:S100 S:S:Y150 8.9 0 No Yes 3 4 2 1
S:S:S149 S:S:Y171 6.36 4 Yes Yes 5 7 1 2
S:S:R277 S:S:Y150 19.55 4 Yes Yes 5 4 2 1
S:S:Y150 X:X:?2 4.31 4 Yes No 4 0 1 2
S:S:Y150 X:X:?3 4.31 4 Yes Yes 4 0 1 2
S:S:S151 S:S:S175 4.89 4 No No 8 7 1 2
S:S:S151 S:S:Y222 5.09 4 No Yes 8 7 1 1
S:S:A172 S:S:Y171 5.34 4 No Yes 5 7 2 2
S:S:A172 S:S:K389 4.82 4 No Yes 5 4 2 1
S:S:D194 S:S:T174 8.67 4 Yes No 8 8 2 1
S:S:D301 S:S:T174 7.23 4 Yes No 8 8 1 1
S:S:D194 S:S:Q197 9.14 4 Yes Yes 8 9 2 2
S:S:D194 S:S:Y222 8.05 4 Yes Yes 8 7 2 1
S:S:D194 S:S:F275 5.97 4 Yes Yes 8 7 2 2
S:S:F275 S:S:Q197 7.03 4 Yes Yes 7 9 2 2
S:S:Q197 S:S:S300 4.33 4 Yes No 9 8 2 2
S:S:D301 S:S:Q197 11.75 4 Yes Yes 8 9 1 2
S:S:F275 S:S:Y222 7.22 4 Yes Yes 7 7 2 1
S:S:S300 S:S:Y222 6.36 4 No Yes 8 7 2 1
S:S:D301 S:S:Y222 11.49 4 Yes Yes 8 7 1 1
S:S:G302 S:S:Y222 4.35 4 No Yes 6 7 1 1
S:S:F275 S:S:S300 9.25 4 Yes No 7 8 2 2
S:S:R277 X:X:?2 8.93 4 Yes No 5 0 2 2
S:S:D301 S:S:L325 4.07 4 Yes No 8 5 1 2
S:S:D301 S:S:K389 6.91 4 Yes Yes 8 4 1 1
S:S:E324 S:S:K389 4.05 0 Yes Yes 5 4 2 1
S:S:E387 S:S:K389 6.75 4 No Yes 6 4 2 1
S:S:F392 S:S:K389 3.72 0 Yes Yes 7 4 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.74
Average Nodes In Shell28.00
Average Hubs In Shell18.00
Average Links In Shell49.00
Average Links Mediated by Hubs In Shell48.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WGC C Aminoacid Metabotropic Glutamate mGlu4; mGlu2 Homo Sapiens LY379268 - - 5.95 2024-11-27 To be published

A 2D representation of the interactions of W92 in 8WGC
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:E273 R:R:S93 4.31 0 No No 1 1 1 2
R:R:D95 R:R:Y144 4.6 12 No Yes 4 3 2 1
R:R:D146 R:R:D95 17.3 12 Yes No 5 4 2 2
R:R:S143 R:R:Y144 6.36 12 Yes Yes 4 3 2 1
R:R:S143 R:R:V147 3.23 12 Yes Yes 4 4 2 2
R:R:D146 R:R:Y144 3.45 12 Yes Yes 5 3 2 1
R:R:V147 R:R:Y144 7.57 12 Yes Yes 4 3 2 1
L:L:?1 R:R:Y144 48.05 0 Yes Yes 0 3 0 1
L:L:?1 R:R:R243 5.71 0 Yes No 0 2 0 1
R:R:E277 R:R:S272 8.62 0 No No 2 2 2 1
L:L:?1 R:R:S272 15.13 0 Yes No 0 2 0 1
L:L:?1 R:R:E273 16.03 0 Yes No 0 1 0 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub1.00
Average Interaction Strength21.23
Average Nodes In Shell11.00
Average Hubs In Shell5.00
Average Links In Shell12.00
Average Links Mediated by Hubs In Shell10.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub5.00
Average Interaction Strength12.90
Average Nodes In Shell22.33
Average Hubs In Shell13.67
Average Links In Shell36.67
Average Links Mediated by Hubs In Shell35.33

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)