CodeWRU
NameMianserin
Synonyms
Identifier
FormulaC18 H20 N2
Molecular Weight264.365
SMILES
PubChem154315
Formal Charge0
Total Atoms40
Total Chiral Atoms1
Total Bonds43
Total Aromatic Bonds12
Networks2
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This ligand is also present in the following 2 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UGY A Amine 5-Hydroxytryptamine 5-HT1E Homo Sapiens Mianserin - Gi1/Beta1/Gamma1 3.31 2024-05-01 doi.org/10.1126/sciadv.adk4855

A 2D representation of the interactions of WRU in 8UGY
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:L99 5.56 2 Yes No 0 5 0 1
L:L:?1 R:R:D102 17.44 2 Yes Yes 0 8 0 1
L:L:?1 R:R:M103 15.9 2 Yes Yes 0 7 0 1
L:L:?1 R:R:C106 5.1 2 Yes No 0 7 0 1
L:L:?1 R:R:T107 3.55 2 Yes No 0 7 0 1
L:L:?1 R:R:I175 14.9 2 Yes No 0 5 0 1
L:L:?1 R:R:S186 3.62 2 Yes No 0 7 0 1
L:L:?1 R:R:F307 13.69 2 Yes Yes 0 7 0 1
L:L:?1 R:R:F308 8.8 2 Yes Yes 0 7 0 1
L:L:?1 R:R:E311 12.77 2 Yes No 0 6 0 1
L:L:?1 R:R:Y334 4.71 2 Yes Yes 0 7 0 1
R:R:V75 R:R:W98 3.68 2 Yes Yes 7 5 2 2
R:R:D102 R:R:V75 13.15 2 Yes Yes 8 7 1 2
R:R:V75 R:R:Y334 5.05 2 Yes Yes 7 7 2 1
R:R:M76 R:R:W331 9.31 2 Yes Yes 7 6 2 2
R:R:M76 R:R:Y334 3.59 2 Yes Yes 7 7 2 1
R:R:S79 R:R:W331 8.65 2 No Yes 6 6 2 2
R:R:S79 R:R:Y334 3.82 2 No Yes 6 7 2 1
R:R:C95 R:R:L99 3.17 19 No No 9 5 2 1
R:R:L99 R:R:W98 3.42 0 No Yes 5 5 1 2
R:R:C106 R:R:D102 4.67 2 No Yes 7 8 1 1
R:R:D102 R:R:Y334 10.34 2 Yes Yes 8 7 1 1
R:R:M103 R:R:S154 6.13 2 Yes Yes 7 7 1 2
R:R:M103 R:R:P157 3.35 2 Yes No 7 7 1 2
R:R:M103 R:R:Y182 3.59 2 Yes Yes 7 7 1 2
R:R:C106 R:R:W304 5.22 2 No Yes 7 8 1 2
R:R:S150 R:R:T107 4.8 0 No No 8 7 2 1
R:R:A190 R:R:T107 5.03 0 No No 6 7 2 1
R:R:P157 R:R:Y182 15.3 2 No Yes 7 7 2 2
R:R:H177 R:R:I175 9.28 0 No No 5 5 2 1
R:R:S186 R:R:Y182 11.45 0 No Yes 7 7 1 2
R:R:F308 R:R:T187 6.49 2 Yes No 7 7 1 2
R:R:F191 R:R:W304 4.01 2 Yes Yes 8 8 2 2
R:R:F191 R:R:F308 22.51 2 Yes Yes 8 7 2 1
R:R:F307 R:R:W304 3.01 2 Yes Yes 7 8 1 2
R:R:F308 R:R:W304 8.02 2 Yes Yes 7 8 1 2
R:R:F307 R:R:K310 4.96 2 Yes Yes 7 5 1 2
R:R:E311 R:R:F307 13.99 2 No Yes 6 7 1 1
R:R:F307 R:R:T330 3.89 2 Yes No 7 4 1 2
R:R:E311 R:R:F308 4.66 2 No Yes 6 7 1 1
R:R:T330 R:R:Y334 4.99 0 No Yes 4 7 2 1
R:R:W331 R:R:Y334 15.43 2 Yes Yes 6 7 2 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub5.00
Average Interaction Strength9.64
Average Nodes In Shell29.00
Average Hubs In Shell15.00
Average Links In Shell42.00
Average Links Mediated by Hubs In Shell38.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.50
Average Interaction Strength9.64
Average Nodes In Shell27.50
Average Hubs In Shell14.00
Average Links In Shell39.00
Average Links Mediated by Hubs In Shell35.50

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)