CodeXZA
Namediazanecarboxylic acid
Synonyms
Identifier
FormulaC H4 N2 O2
Molecular Weight76.055
SMILES
PubChem129728243
Formal Charge0
Total Atoms9
Total Chiral Atoms0
Total Bonds8
Total Aromatic Bonds0
Networks6
 missing image

This ligand is also present in the following 6 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XGO A Peptide Kisspeptin Kiss1 Homo Sapiens TAK448 - chim(NtGi1-Gq)/Beta1/Gamma2 2.68 2024-10-30 doi.org/10.1126/sciadv.adn7771

A 2D representation of the interactions of XZA in 8XGO
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:N4 R:R:L102 6.87 3 Yes No 0 5 2 1
L:L:?5 R:R:L102 5.11 3 Yes No 0 5 2 1
L:L:?7 R:R:L102 5.35 0 No No 0 5 0 1
L:L:L8 R:R:N119 8.24 0 Yes No 0 5 1 2
L:L:L8 R:R:Q122 5.32 0 Yes Yes 0 6 1 2
L:L:?5 L:L:N4 8.87 3 Yes Yes 0 0 2 2
L:L:?7 L:L:L8 8.02 0 No Yes 0 0 0 1
L:L:?9 L:L:L8 5.49 13 Yes Yes 0 0 2 1
StatisticsValue
Average Number Of Links2.00
Average Number Of Links With An Hub1.00
Average Interaction Strength6.68
Average Nodes In Shell8.00
Average Hubs In Shell5.00
Average Links In Shell8.00
Average Links Mediated by Hubs In Shell7.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XGU A Peptide Kisspeptin Kiss1 Homo Sapiens TAK448 - Gi1/Beta1/Gamma2 3 2024-10-30 doi.org/10.1126/sciadv.adn7771

A 2D representation of the interactions of XZA in 8XGU
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:N4 R:R:L102 6.87 6 No No 0 5 2 1
L:L:?7 L:L:L8 8.02 0 No Yes 0 0 0 1
L:L:?7 R:R:L102 4.01 0 No No 0 5 0 1
L:L:?9 L:L:L8 3.29 2 Yes Yes 0 0 2 1
L:L:?11 L:L:L8 10.28 2 Yes Yes 0 0 2 1
L:L:L8 R:R:T99 4.42 2 Yes No 0 6 1 2
L:L:L8 R:R:V118 2.98 2 Yes No 0 5 1 2
L:L:L8 R:R:N119 6.87 2 Yes Yes 0 5 1 2
L:L:L8 R:R:Q122 3.99 2 Yes Yes 0 6 1 2
L:L:?11 L:L:?9 8.15 2 Yes Yes 0 0 2 2
L:L:?9 R:R:N119 3.27 2 Yes Yes 0 5 2 2
L:L:?11 R:R:T99 10.94 2 Yes No 0 6 2 2
L:L:?11 R:R:Q122 6.59 2 Yes Yes 0 6 2 2
R:R:L102 R:R:Y103 4.69 0 No Yes 5 5 1 2
R:R:Q122 R:R:V118 2.87 2 Yes No 6 5 2 2
StatisticsValue
Average Number Of Links2.00
Average Number Of Links With An Hub1.00
Average Interaction Strength6.01
Average Nodes In Shell11.00
Average Hubs In Shell6.00
Average Links In Shell15.00
Average Links Mediated by Hubs In Shell13.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ZJE A Peptide Kisspeptin Kiss1 Homo Sapiens TAK-448 - chim(NtGi1-Gq)/Beta1/Gamma1 3.07 2024-07-03 To be published

A 2D representation of the interactions of XZA in 8ZJE
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F98 R:R:L101 4.87 1 Yes Yes 6 4 2 2
L:L:L8 R:R:F98 3.65 1 Yes Yes 0 6 1 2
R:R:L101 R:R:W108 4.56 1 Yes Yes 4 8 2 2
L:L:L8 R:R:L101 5.54 1 Yes Yes 0 4 1 2
R:R:C115 R:R:W108 3.92 1 No Yes 9 8 2 2
R:R:C191 R:R:W108 11.75 1 Yes Yes 9 8 1 2
R:R:C115 R:R:C191 5.46 1 No Yes 9 9 2 1
L:L:L8 R:R:V118 5.96 1 Yes No 0 5 1 2
L:L:L8 R:R:N119 8.24 1 Yes No 0 5 1 2
L:L:?9 R:R:N119 4.27 1 Yes No 0 5 2 2
L:L:L8 R:R:Q122 7.99 1 Yes No 0 6 1 2
L:L:?3 R:R:Y190 24.58 1 Yes No 0 4 1 2
L:L:?7 R:R:C191 4.08 1 No Yes 0 9 0 1
L:L:L8 R:R:C191 3.17 1 Yes Yes 0 9 1 1
L:L:?1 L:L:?2 24.1 1 No No 0 0 2 2
L:L:?1 L:L:?3 3.24 1 No Yes 0 0 2 1
L:L:?2 L:L:?3 24.17 1 No Yes 0 0 2 1
L:L:?3 L:L:F6 3.33 1 Yes Yes 0 0 1 2
L:L:?3 L:L:?7 3.25 1 Yes No 0 0 1 0
L:L:?7 L:L:L8 4.75 1 No Yes 0 0 0 1
L:L:?9 L:L:L8 3.23 1 Yes Yes 0 0 2 1
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub3.00
Average Interaction Strength4.03
Average Nodes In Shell16.00
Average Hubs In Shell8.00
Average Links In Shell21.00
Average Links Mediated by Hubs In Shell20.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links2.33
Average Number Of Links With An Hub1.67
Average Interaction Strength5.58
Average Nodes In Shell11.67
Average Hubs In Shell6.33
Average Links In Shell14.67
Average Links Mediated by Hubs In Shell13.33

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)