CodeYFW
Name5-methoxy-N,N-dimethyltryptamine
Synonyms5-MeO-DMT
Identifier
FormulaC13 H18 N2 O
Molecular Weight218.295
SMILES
PubChem1832
Formal Charge0
Total Atoms34
Total Chiral Atoms0
Total Bonds35
Total Aromatic Bonds10
Networks2
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This ligand is also present in the following 2 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8FY8 A Amine 5-Hydroxytryptamine 5-HT1A Homo Sapiens 5-MeO-DMT - Gi1/Beta1/Gamma1 2.79 2024-05-15 doi.org/10.1038/s41586-024-07403-2

A 2D representation of the interactions of YFW in 8FY8
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D116 13.85 2 Yes No 0 8 0 1
L:L:?1 R:R:V117 11.94 2 Yes No 0 8 0 1
L:L:?1 R:R:C120 4.63 2 Yes No 0 7 0 1
L:L:?1 R:R:T121 5.37 2 Yes Yes 0 8 0 1
L:L:?1 R:R:I189 10.4 2 Yes No 0 6 0 1
L:L:?1 R:R:S199 8.75 2 Yes No 0 8 0 1
L:L:?1 R:R:A203 3.45 2 Yes No 0 8 0 1
L:L:?1 R:R:W358 4.15 2 Yes Yes 0 8 0 1
L:L:?1 R:R:F361 16.87 2 Yes Yes 0 8 0 1
L:L:?1 R:R:F362 11.54 2 Yes Yes 0 7 0 1
L:L:?1 R:R:Y390 11.96 2 Yes Yes 0 8 0 1
R:R:L90 R:R:V85 2.98 2 Yes Yes 8 8 2 2
R:R:C120 R:R:V85 3.42 2 No Yes 7 8 1 2
R:R:D116 R:R:V89 4.38 2 No Yes 8 8 1 2
R:R:V89 R:R:Y390 3.79 2 Yes Yes 8 8 2 1
R:R:L90 R:R:W387 4.56 2 Yes Yes 8 8 2 2
R:R:L90 R:R:Y390 5.86 2 Yes Yes 8 8 2 1
R:R:A93 R:R:Y390 4 0 No Yes 7 8 2 1
R:R:D116 R:R:Y390 8.05 2 No Yes 8 8 1 1
R:R:I167 R:R:V117 3.07 0 Yes No 8 8 2 1
R:R:S168 R:R:V117 4.85 0 No No 8 8 2 1
R:R:C120 R:R:W358 5.22 2 No Yes 7 8 1 1
R:R:G164 R:R:T121 3.64 0 No Yes 8 8 2 1
R:R:I167 R:R:T121 4.56 0 Yes Yes 8 8 2 1
R:R:A203 R:R:T121 5.03 2 No Yes 8 8 1 1
R:R:F354 R:R:I124 5.02 2 Yes No 9 8 2 2
R:R:I124 R:R:W358 15.27 2 No Yes 8 8 2 1
R:R:S199 R:R:Y195 13.99 0 No Yes 8 8 1 2
R:R:T200 R:R:Y205 3.75 2 No Yes 7 7 2 2
R:R:F362 R:R:T200 5.19 2 Yes No 7 7 1 2
R:R:F204 R:R:Y205 8.25 2 Yes Yes 8 7 2 2
R:R:F204 R:R:F354 6.43 2 Yes Yes 8 9 2 2
R:R:F204 R:R:W358 3.01 2 Yes Yes 8 8 2 1
R:R:F204 R:R:F362 19.29 2 Yes Yes 8 7 2 1
R:R:F362 R:R:Y205 3.09 2 Yes Yes 7 7 1 2
R:R:F354 R:R:W358 4.01 2 Yes Yes 9 8 2 1
R:R:F362 R:R:W358 7.02 2 Yes Yes 7 8 1 1
R:R:G389 R:R:W358 8.44 0 No Yes 8 8 2 1
R:R:N392 R:R:W358 13.56 0 No Yes 9 8 2 1
R:R:F361 R:R:F362 13.93 2 Yes Yes 8 7 1 1
R:R:F361 R:R:I385 3.77 2 Yes No 8 6 1 2
R:R:F361 R:R:N386 7.25 2 Yes No 8 7 1 2
R:R:W387 R:R:Y390 16.4 2 Yes Yes 8 8 2 1
R:R:A365 R:R:F361 2.77 0 No Yes 8 8 2 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub5.00
Average Interaction Strength9.36
Average Nodes In Shell31.00
Average Hubs In Shell15.00
Average Links In Shell44.00
Average Links Mediated by Hubs In Shell43.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub5.00
Average Interaction Strength9.36
Average Nodes In Shell31.00
Average Hubs In Shell14.50
Average Links In Shell43.00
Average Links Mediated by Hubs In Shell41.50

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)