CodeYG7
NameVilazodone
Synonyms
  • Vilazodone
  • Vilazodone hydrochloride
  • Vilazodonum
  • Vilazodona
Identifier
FormulaC26 H27 N5 O2
Molecular Weight441.525
SMILES
PubChem6918314
Formal Charge0
Total Atoms60
Total Chiral Atoms0
Total Bonds64
Total Aromatic Bonds20
Networks2
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This ligand is also present in the following 2 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8FYL A Amine 5-Hydroxytryptamine 5-HT1A Homo Sapiens Vilazodone - Gi1/Beta1/Gamma1 2.94 2024-05-15 doi.org/10.1038/s41586-024-07403-2

A 2D representation of the interactions of YG7 in 8FYL
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Y96 25.61 3 Yes No 0 6 0 1
L:L:?1 R:R:Q97 15.78 3 Yes No 0 7 0 1
L:L:?1 R:R:D116 12.7 3 Yes Yes 0 8 0 1
L:L:?1 R:R:V117 7.44 3 Yes No 0 8 0 1
L:L:?1 R:R:C120 3.96 3 Yes No 0 7 0 1
L:L:?1 R:R:T121 4.6 3 Yes Yes 0 8 0 1
L:L:?1 R:R:I189 6.24 3 Yes No 0 6 0 1
L:L:?1 R:R:S199 5.62 3 Yes No 0 8 0 1
L:L:?1 R:R:A203 2.95 3 Yes No 0 8 0 1
L:L:?1 R:R:W358 2.84 3 Yes Yes 0 8 0 1
L:L:?1 R:R:F361 10.64 3 Yes No 0 8 0 1
L:L:?1 R:R:F362 6.84 3 Yes Yes 0 7 0 1
L:L:?1 R:R:N386 12.85 3 Yes No 0 7 0 1
L:L:?1 R:R:W387 4.26 3 Yes Yes 0 8 0 1
L:L:?1 R:R:Y390 10.24 3 Yes Yes 0 8 0 1
R:R:L43 R:R:W387 9.11 0 Yes Yes 7 8 2 1
R:R:D116 R:R:V89 5.84 3 Yes No 8 8 1 2
R:R:V89 R:R:Y390 3.79 3 No Yes 8 8 2 1
R:R:L90 R:R:Y390 8.21 0 Yes Yes 8 8 2 1
R:R:A93 R:R:F112 2.77 0 No Yes 7 6 2 2
R:R:A93 R:R:Y390 4 0 No Yes 7 8 2 1
R:R:W102 R:R:Y96 10.61 3 Yes No 9 6 2 1
R:R:A383 R:R:Q97 3.03 0 No No 6 7 2 1
R:R:Q97 R:R:W387 7.67 3 No Yes 7 8 1 1
R:R:F112 R:R:W102 8.02 3 Yes Yes 6 9 2 2
R:R:F112 R:R:I113 3.77 3 Yes Yes 6 7 2 2
R:R:D116 R:R:F112 5.97 3 Yes Yes 8 6 1 2
R:R:I113 R:R:I189 2.94 0 Yes No 7 6 2 1
R:R:D116 R:R:Y390 8.05 3 Yes Yes 8 8 1 1
R:R:I167 R:R:V117 3.07 0 Yes No 8 8 2 1
R:R:S168 R:R:V117 4.85 0 No No 8 8 2 1
R:R:C120 R:R:W358 5.22 3 No Yes 7 8 1 1
R:R:G164 R:R:T121 3.64 0 No Yes 8 8 2 1
R:R:I167 R:R:T121 6.08 0 Yes Yes 8 8 2 1
R:R:A203 R:R:T121 5.03 3 No Yes 8 8 1 1
R:R:F354 R:R:I124 3.77 3 Yes No 9 8 2 2
R:R:I124 R:R:W358 9.4 3 No Yes 8 8 2 1
R:R:S199 R:R:Y195 8.9 0 No No 8 8 1 2
R:R:A203 R:R:F362 2.77 3 No Yes 8 7 1 1
R:R:F204 R:R:F354 5.36 3 Yes Yes 8 9 2 2
R:R:F204 R:R:W358 3.01 3 Yes Yes 8 8 2 1
R:R:F204 R:R:F362 19.29 3 Yes Yes 8 7 2 1
R:R:F354 R:R:W358 4.01 3 Yes Yes 9 8 2 1
R:R:F362 R:R:W358 5.01 3 Yes Yes 7 8 1 1
R:R:G389 R:R:W358 8.44 0 No Yes 8 8 2 1
R:R:N392 R:R:W358 6.78 0 No Yes 9 8 2 1
R:R:F361 R:R:F362 4.29 3 No Yes 8 7 1 1
R:R:W387 R:R:Y390 10.61 3 Yes Yes 8 8 1 1
L:L:?1 R:R:N100 2.57 3 Yes No 0 5 0 1
L:L:?1 R:R:A365 1.97 3 Yes No 0 8 0 1
R:R:G382 R:R:N386 1.7 0 No No 4 7 2 1
R:R:A186 R:R:Y96 1.33 0 No No 4 6 2 1
StatisticsValue
Average Number Of Links17.00
Average Number Of Links With An Hub6.00
Average Interaction Strength8.07
Average Nodes In Shell37.00
Average Hubs In Shell15.00
Average Links In Shell52.00
Average Links Mediated by Hubs In Shell47.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links16.00
Average Number Of Links With An Hub5.50
Average Interaction Strength8.41
Average Nodes In Shell34.50
Average Hubs In Shell13.50
Average Links In Shell45.00
Average Links Mediated by Hubs In Shell40.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)