psnGPCR

Code	YP1
Name	NPS-2143
Synonyms	NPS-2143
Identifier	2-chloranyl-6-[(2~{R})-3-[(2-methyl-1-naphthalen-2-yl-propan-2-yl)amino]-2-oxidanyl-propoxy]benzenecarbonitrile
Formula	C24 H25 Cl N2 O2
Molecular Weight	408.921
SMILES	CC(C)(Cc1ccc2ccccc2c1)NC[C@H](COc3cccc(c3C#N)Cl)O
PubChem	6918446
Formal Charge	0
Total Atoms	54
Total Chiral Atoms	1
Total Bonds	56
Total Aromatic Bonds	17
Networks	4

This ligand is also present in the following 4 networks:

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7DD5

Ion

Calcium-sensing

CaS

Gallus gallus

Ca; Ca; Tryptophan; NPS-2143

3.2

2021-06-16

10.1126/sciadv.abg1483

A 2D representation of the interactions of YP1 in 7DD5
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E837	R:R:F668	3.5	12	No	Yes	7	8	1	2
R:R:F684	R:R:G685	4.52	12	Yes	No	6	6	1	2
R:R:F684	R:R:F688	12.86	12	Yes	Yes	6	8	1	2
R:R:F684	R:R:I841	8.79	12	Yes	No	6	8	1	1
R:R:F684	W:W:?1109	15.26	12	Yes	Yes	6	0	1	0
R:R:L773	R:R:W742	5.69	0	No	Yes	5	7	1	2
R:R:L773	W:W:?1109	4.08	0	No	Yes	5	0	1	0
R:R:I777	R:R:W818	3.52	12	No	Yes	5	6	1	1
R:R:I777	W:W:?1109	8.42	12	No	Yes	5	0	1	0
R:R:I819	R:R:W818	5.87	0	No	Yes	7	6	2	1
R:R:W818	W:W:?1109	5.88	12	Yes	Yes	6	0	1	0
R:R:F821	R:R:Y825	5.16	12	Yes	Yes	7	7	1	1
R:R:E837	R:R:F821	5.83	12	No	Yes	7	7	1	1
R:R:A840	R:R:F821	4.16	0	No	Yes	9	7	2	1
R:R:F821	W:W:?1109	8.98	12	Yes	Yes	7	0	1	0
R:R:V833	R:R:Y825	13.88	0	No	Yes	8	7	2	1
R:R:Y825	W:W:?1109	9.5	12	Yes	Yes	7	0	1	0
R:R:E837	W:W:?1109	23.44	12	No	Yes	7	0	1	0
R:R:I841	W:W:?1109	10.52	12	No	Yes	8	0	1	0
R:R:F821	R:R:V836	2.62	12	Yes	No	7	9	1	2
R:R:I822	R:R:W818	2.35	0	No	Yes	8	6	2	1
R:R:G774	R:R:L773	1.71	0	No	No	4	5	2	1
R:R:C781	R:R:I777	1.64	0	No	No	4	5	2	1
R:R:A826	R:R:Y825	1.33	0	No	Yes	9	7	2	1

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	10.76
Average Nodes In Shell	21.00
Average Hubs In Shell	8.00
Average Links In Shell	24.00
Average Links Mediated by Hubs In Shell	22.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of YP1 in 7DD5
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:F684	S:S:G685	6.02	15	Yes	No	6	6	1	2
S:S:F684	S:S:F688	6.43	15	Yes	Yes	6	8	1	2
S:S:F684	S:S:I841	6.28	15	Yes	No	6	8	1	2
S:S:F684	X:X:?1108	16.16	15	Yes	Yes	6	0	1	0
S:S:F688	S:S:I841	3.77	15	Yes	No	8	8	2	2
S:S:I777	S:S:L776	2.85	0	No	No	5	8	1	2
S:S:I777	X:X:?1108	5.26	0	No	Yes	5	0	1	0
S:S:I819	S:S:W818	4.7	0	No	No	7	6	2	1
S:S:I822	S:S:W818	7.05	0	No	No	8	6	2	1
S:S:W818	X:X:?1108	5.88	0	No	Yes	6	0	1	0
S:S:F821	S:S:Y825	4.13	15	Yes	No	7	7	1	1
S:S:E837	S:S:F821	8.16	15	No	Yes	7	7	1	1
S:S:A840	S:S:F821	4.16	0	No	Yes	9	7	2	1
S:S:F821	X:X:?1108	8.98	15	Yes	Yes	7	0	1	0
S:S:V833	S:S:Y825	7.57	0	No	No	8	7	2	1
S:S:Y825	X:X:?1108	12.1	15	No	Yes	7	0	1	0
S:S:E837	X:X:?1108	17.58	15	No	Yes	7	0	1	0
S:S:E837	S:S:F668	2.33	15	No	Yes	7	8	1	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	10.99
Average Nodes In Shell	16.00
Average Hubs In Shell	5.00
Average Links In Shell	18.00
Average Links Mediated by Hubs In Shell	14.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7M3E

Ion

Calcium-sensing

CaS

Homo sapiens

Ca; Ca; Tryptophan; NPS-2143; PO4

3.2

2021-06-30

10.1038/s41586-021-03691-0

A 2D representation of the interactions of YP1 in 7M3E
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E837	R:R:F668	9.33	14	No	No	9	9	1	2
R:R:Q681	R:R:W742	3.29	14	Yes	Yes	9	9	1	2
R:R:E767	R:R:Q681	6.37	14	No	Yes	7	9	2	1
R:R:L773	R:R:Q681	3.99	14	No	Yes	8	9	2	1
R:R:Q681	W:W:?901	10.79	14	Yes	Yes	9	0	1	0
R:R:F684	R:R:G685	4.52	0	Yes	No	8	8	1	2
R:R:F684	R:R:F688	8.57	0	Yes	Yes	8	8	1	2
R:R:F684	R:R:I841	3.77	0	Yes	No	8	9	1	2
R:R:F684	W:W:?901	16.16	0	Yes	Yes	8	0	1	0
R:R:F688	R:R:F814	3.22	0	Yes	Yes	8	9	2	1
R:R:E767	R:R:L773	2.65	14	No	No	7	8	2	2
R:R:I777	W:W:?901	6.31	0	No	Yes	8	0	1	0
R:R:C781	R:R:W818	7.84	0	No	No	7	9	2	1
R:R:A784	R:R:F814	2.77	0	No	Yes	8	9	2	1
R:R:F814	R:R:F815	4.29	0	Yes	No	9	7	1	2
R:R:F814	W:W:?901	7.18	0	Yes	Yes	9	0	1	0
R:R:W818	W:W:?901	19.31	0	No	Yes	9	0	1	0
R:R:F821	R:R:Y825	6.19	14	Yes	Yes	9	9	1	1
R:R:F821	R:R:V836	2.62	14	Yes	No	9	8	1	2
R:R:A840	R:R:F821	5.55	0	No	Yes	9	9	2	1
R:R:F821	W:W:?901	14.36	14	Yes	Yes	9	0	1	0
R:R:I822	R:R:P823	3.39	0	No	No	7	9	1	2
R:R:I822	W:W:?901	7.36	0	No	Yes	7	0	1	0
R:R:V833	R:R:Y825	5.05	0	Yes	Yes	6	9	2	1
R:R:E837	R:R:Y825	6.73	14	No	Yes	9	9	1	1
R:R:Y825	W:W:?901	14.69	14	Yes	Yes	9	0	1	0
R:R:E837	W:W:?901	6.84	14	No	Yes	9	0	1	0

Statistics	Value
Average Number Of Links	9.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	11.44
Average Nodes In Shell	24.00
Average Hubs In Shell	9.00
Average Links In Shell	27.00
Average Links Mediated by Hubs In Shell	23.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of YP1 in 7M3E
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:E837	S:S:F668	9.33	18	No	No	9	9	1	2
S:S:Q681	S:S:W742	3.29	18	Yes	No	9	9	1	2
S:S:E767	S:S:Q681	6.37	18	No	Yes	7	9	2	1
S:S:L773	S:S:Q681	3.99	18	No	Yes	8	9	2	1
S:S:L776	S:S:Q681	2.66	0	No	Yes	8	9	2	1
S:S:Q681	X:X:?901	10.79	18	Yes	Yes	9	0	1	0
S:S:F684	S:S:G685	4.52	0	Yes	No	8	8	1	2
S:S:F684	S:S:F688	8.57	0	Yes	Yes	8	8	1	2
S:S:F684	X:X:?901	17.06	0	Yes	Yes	8	0	1	0
S:S:F688	S:S:F814	3.22	0	Yes	No	8	9	2	1
S:S:E767	S:S:L773	2.65	18	No	No	7	8	2	2
S:S:I777	X:X:?901	6.31	0	No	Yes	8	0	1	0
S:S:C781	S:S:W818	7.84	0	No	No	7	9	2	1
S:S:A784	S:S:F814	2.77	0	No	No	8	9	2	1
S:S:F814	X:X:?901	7.18	0	No	Yes	9	0	1	0
S:S:W818	X:X:?901	19.31	0	No	Yes	9	0	1	0
S:S:F821	S:S:Y825	6.19	18	Yes	Yes	9	9	1	1
S:S:F821	S:S:V836	2.62	18	Yes	No	9	8	1	2
S:S:A840	S:S:F821	5.55	0	No	Yes	9	9	2	1
S:S:F821	X:X:?901	14.36	18	Yes	Yes	9	0	1	0
S:S:I822	S:S:P823	3.39	0	No	No	7	9	1	2
S:S:I822	X:X:?901	7.36	0	No	Yes	7	0	1	0
S:S:V833	S:S:Y825	3.79	0	No	Yes	6	9	2	1
S:S:E837	S:S:Y825	5.61	18	No	Yes	9	9	1	1
S:S:Y825	X:X:?901	12.96	18	Yes	Yes	9	0	1	0
S:S:E837	X:X:?901	6.84	18	No	Yes	9	0	1	0
S:S:F668	S:S:I841	2.51	0	No	No	9	9	2	2
S:S:F684	S:S:I841	2.51	0	Yes	No	8	9	1	2

Statistics	Value
Average Number Of Links	9.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	11.35
Average Nodes In Shell	24.00
Average Hubs In Shell	6.00
Average Links In Shell	28.00
Average Links Mediated by Hubs In Shell	22.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7M3J

Ion

Calcium-sensing

CaS

Homo sapiens

NPS-2143; PO4

4.1

2021-06-30

10.1038/s41586-021-03691-0

A 2D representation of the interactions of YP1 in 7M3J
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I841	R:R:S665	3.1	0	No	Yes	9	8	1	2
R:R:F668	R:R:R680	3.21	5	Yes	Yes	9	8	2	2
R:R:F668	R:R:Q681	2.34	5	Yes	Yes	9	9	2	1
R:R:E837	R:R:F668	10.49	5	No	Yes	9	9	1	2
R:R:Q681	R:R:R680	15.19	5	Yes	Yes	9	8	1	2
R:R:P682	R:R:Q681	1.58	5	Yes	Yes	5	9	2	1
R:R:L773	R:R:Q681	3.99	0	No	Yes	8	9	2	1
R:R:Q681	W:W:?901	11.77	5	Yes	Yes	9	0	1	0
R:R:F684	R:R:G685	4.52	0	No	No	8	8	1	2
R:R:F684	R:R:F688	2.14	0	No	Yes	8	8	1	2
R:R:F684	W:W:?901	10.77	0	No	Yes	8	0	1	0
R:R:F688	R:R:T780	3.89	0	Yes	Yes	8	7	2	2
R:R:F688	R:R:F814	9.65	0	Yes	Yes	8	9	2	1
R:R:G774	R:R:I777	3.53	0	No	Yes	4	8	2	1
R:R:G778	R:R:I777	1.76	0	No	Yes	5	8	2	1
R:R:I777	R:R:T780	1.52	5	Yes	Yes	8	7	1	2
R:R:C781	R:R:I777	1.64	5	No	Yes	7	8	2	1
R:R:I777	W:W:?901	10.52	5	Yes	Yes	8	0	1	0
R:R:C781	R:R:T780	1.69	5	No	Yes	7	7	2	2
R:R:C781	R:R:W818	5.22	5	No	Yes	7	9	2	1
R:R:A784	R:R:F814	2.77	5	No	Yes	8	9	2	1
R:R:A784	R:R:F815	4.16	5	No	Yes	8	7	2	2
R:R:F814	R:R:F815	7.5	5	Yes	Yes	9	7	1	2
R:R:F814	W:W:?901	4.49	5	Yes	Yes	9	0	1	0
R:R:I822	R:R:W818	2.35	5	Yes	Yes	7	9	1	1
R:R:W818	W:W:?901	5.88	5	Yes	Yes	9	0	1	0
R:R:F821	R:R:I822	3.77	5	Yes	Yes	9	7	1	1
R:R:F821	R:R:Y825	9.28	5	Yes	No	9	9	1	1
R:R:E837	R:R:F821	10.49	5	No	Yes	9	9	1	1
R:R:F821	W:W:?901	22.44	5	Yes	Yes	9	0	1	0
R:R:I822	R:R:P823	3.39	5	Yes	No	7	9	1	2
R:R:I822	W:W:?901	2.1	5	Yes	Yes	7	0	1	0
R:R:V833	R:R:Y825	2.52	0	No	No	6	9	2	1
R:R:Y825	W:W:?901	18.14	5	No	Yes	9	0	1	0
R:R:E837	W:W:?901	21.49	5	No	Yes	9	0	1	0
R:R:I841	W:W:?901	5.26	0	No	Yes	9	0	1	0
R:R:I819	R:R:W818	1.17	0	No	Yes	6	9	2	1
R:R:A840	W:W:?901	1.16	0	No	Yes	9	0	1	0

Statistics	Value
Average Number Of Links	11.00
Average Number Of Links With An Hub	6.00
Average Interaction Strength	10.37
Average Nodes In Shell	28.00
Average Hubs In Shell	14.00
Average Links In Shell	38.00
Average Links Mediated by Hubs In Shell	36.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of YP1 in 7M3J
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:I841	S:S:S664	1.55	3	Yes	No	9	6	1	2
S:S:I841	S:S:S665	3.1	3	Yes	Yes	9	8	1	2
S:S:F668	S:S:R680	13.9	3	No	Yes	9	8	2	2
S:S:F668	S:S:Q681	2.34	3	No	Yes	9	9	2	1
S:S:Q681	S:S:R680	11.68	3	Yes	Yes	9	8	1	2
S:S:P682	S:S:Q681	1.58	0	No	Yes	5	9	2	1
S:S:L773	S:S:Q681	5.32	0	No	Yes	8	9	2	1
S:S:Q681	X:X:?901	12.75	3	Yes	Yes	9	0	1	0
S:S:F684	S:S:G685	3.01	3	Yes	No	8	8	1	2
S:S:F684	S:S:F688	6.43	3	Yes	No	8	8	1	2
S:S:F684	S:S:I841	2.51	3	Yes	Yes	8	9	1	1
S:S:F684	X:X:?901	16.16	3	Yes	Yes	8	0	1	0
S:S:F688	S:S:F814	3.22	3	No	Yes	8	9	2	1
S:S:F688	S:S:L848	2.44	3	No	No	8	7	2	2
S:S:I777	S:S:L773	5.71	0	Yes	No	8	8	1	2
S:S:G774	S:S:I777	5.29	0	No	Yes	4	8	2	1
S:S:G778	S:S:I777	1.76	0	No	Yes	5	8	2	1
S:S:I777	X:X:?901	7.36	0	Yes	Yes	8	0	1	0
S:S:A784	S:S:F814	2.77	0	Yes	Yes	8	9	2	1
S:S:F814	S:S:L848	3.65	3	Yes	No	9	7	1	2
S:S:F814	X:X:?901	2.69	3	Yes	Yes	9	0	1	0
S:S:A844	S:S:V817	1.7	0	No	No	9	9	1	2
S:S:I819	S:S:W818	2.35	0	No	No	6	9	2	1
S:S:I822	S:S:W818	3.52	3	Yes	No	7	9	1	1
S:S:W818	X:X:?901	9.23	3	No	Yes	9	0	1	0
S:S:F821	S:S:I822	3.77	3	Yes	Yes	9	7	1	1
S:S:F821	S:S:Y825	10.32	3	Yes	No	9	9	1	1
S:S:E837	S:S:F821	7	3	No	Yes	9	9	1	1
S:S:A840	S:S:F821	2.77	3	No	Yes	9	9	1	1
S:S:F821	X:X:?901	25.13	3	Yes	Yes	9	0	1	0
S:S:I822	S:S:P823	3.39	3	Yes	No	7	9	1	2
S:S:I822	X:X:?901	5.26	3	Yes	Yes	7	0	1	0
S:S:V833	S:S:Y825	5.05	0	No	No	6	9	2	1
S:S:Y825	X:X:?901	13.82	3	No	Yes	9	0	1	0
S:S:E837	X:X:?901	23.44	3	No	Yes	9	0	1	0
S:S:A840	X:X:?901	3.48	3	No	Yes	9	0	1	0
S:S:I841	X:X:?901	6.31	3	Yes	Yes	9	0	1	0
S:S:A844	X:X:?901	2.32	0	No	Yes	9	0	1	0

Statistics	Value
Average Number Of Links	12.00
Average Number Of Links With An Hub	7.00
Average Interaction Strength	10.66
Average Nodes In Shell	29.00
Average Hubs In Shell	11.00
Average Links In Shell	38.00
Average Links Mediated by Hubs In Shell	34.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7SIN

Ion

Calcium-sensing

CaS

Homo sapiens

NPS-2143

5.9

2022-01-19

10.1073/pnas.2115849118

A 2D representation of the interactions of YP1 in 7SIN
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I841	R:R:S665	9.29	4	No	No	9	8	1	2
R:R:F668	R:R:R680	13.9	4	Yes	No	9	8	2	2
R:R:E837	R:R:F668	9.33	4	No	Yes	9	9	1	2
R:R:Q681	R:R:R680	18.69	4	Yes	No	9	8	1	2
R:R:P682	R:R:Q681	3.16	0	No	Yes	5	9	2	1
R:R:L773	R:R:Q681	9.32	4	No	Yes	8	9	1	1
R:R:E837	R:R:Q681	6.37	4	No	Yes	9	9	1	1
R:R:Q681	W:W:?1	17.66	4	Yes	Yes	9	0	1	0
R:R:F684	R:R:G685	4.52	4	Yes	No	8	8	1	2
R:R:F684	R:R:F688	6.43	4	Yes	Yes	8	8	1	2
R:R:F684	R:R:I841	6.28	4	Yes	No	8	9	1	1
R:R:F684	W:W:?1	25.13	4	Yes	Yes	8	0	1	0
R:R:F688	R:R:F814	13.93	0	Yes	No	8	9	2	1
R:R:E767	R:R:P748	3.14	4	Yes	No	7	9	1	2
R:R:E767	R:R:H766	6.15	4	Yes	No	7	6	1	2
R:R:E767	R:R:L770	3.98	4	Yes	No	7	3	1	1
R:R:E767	W:W:?1	9.77	4	Yes	Yes	7	0	1	0
R:R:L770	W:W:?1	9.18	4	No	Yes	3	0	1	0
R:R:L773	W:W:?1	9.18	4	No	Yes	8	0	1	0
R:R:I777	R:R:W818	4.7	4	No	Yes	8	9	1	1
R:R:I777	W:W:?1	6.31	4	No	Yes	8	0	1	0
R:R:C781	R:R:W818	9.14	0	No	Yes	7	9	2	1
R:R:F814	W:W:?1	4.49	0	No	Yes	9	0	1	0
R:R:F815	R:R:W818	5.01	4	No	Yes	7	9	2	1
R:R:F815	R:R:I819	5.02	4	No	No	7	6	2	2
R:R:I819	R:R:W818	3.52	4	No	Yes	6	9	2	1
R:R:F821	R:R:W818	4.01	4	No	Yes	9	9	1	1
R:R:W818	W:W:?1	7.55	4	Yes	Yes	9	0	1	0
R:R:F821	W:W:?1	8.08	4	No	Yes	9	0	1	0
R:R:I822	R:R:Y825	4.84	0	No	No	7	9	2	1
R:R:Y825	R:R:Y829	3.97	0	No	No	9	6	1	2
R:R:Y825	W:W:?1	20.74	0	No	Yes	9	0	1	0
R:R:E837	W:W:?1	23.44	4	No	Yes	9	0	1	0
R:R:I841	W:W:?1	5.26	4	No	Yes	9	0	1	0
R:R:A844	R:R:F814	2.77	0	No	No	9	9	2	1
R:R:A840	R:R:F821	2.77	0	No	No	9	9	2	1
R:R:G774	R:R:I777	1.76	0	No	No	4	8	2	1

Statistics	Value
Average Number Of Links	12.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	12.23
Average Nodes In Shell	29.00
Average Hubs In Shell	7.00
Average Links In Shell	37.00
Average Links Mediated by Hubs In Shell	30.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of YP1 in 7SIN
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:I841	S:S:S665	4.64	10	Yes	No	9	8	1	2
S:S:F668	S:S:R680	12.83	0	Yes	No	9	8	2	2
S:S:E837	S:S:F668	10.49	10	No	Yes	9	9	1	2
S:S:F668	S:S:V838	3.93	0	Yes	No	9	7	2	2
S:S:Q681	S:S:R680	15.19	10	Yes	No	9	8	1	2
S:S:P682	S:S:Q681	3.16	0	No	Yes	5	9	2	1
S:S:L773	S:S:Q681	10.65	10	No	Yes	8	9	1	1
S:S:E837	S:S:Q681	5.1	10	No	Yes	9	9	1	1
S:S:Q681	X:X:?1	17.66	10	Yes	Yes	9	0	1	0
S:S:F684	S:S:G685	4.52	10	Yes	No	8	8	1	2
S:S:F684	S:S:F688	7.5	10	Yes	Yes	8	8	1	2
S:S:F684	S:S:I841	7.54	10	Yes	Yes	8	9	1	1
S:S:F684	X:X:?1	28.73	10	Yes	Yes	8	0	1	0
S:S:F688	S:S:F814	12.86	0	Yes	No	8	9	2	1
S:S:E767	S:S:P748	3.14	10	Yes	No	7	9	1	2
S:S:E767	S:S:H766	6.15	10	Yes	No	7	6	1	2
S:S:E767	S:S:L770	3.98	10	Yes	No	7	3	1	1
S:S:E767	X:X:?1	7.81	10	Yes	Yes	7	0	1	0
S:S:L770	X:X:?1	3.06	10	No	Yes	3	0	1	0
S:S:L773	X:X:?1	10.2	10	No	Yes	8	0	1	0
S:S:I777	S:S:W818	3.52	10	No	Yes	8	9	1	1
S:S:I777	X:X:?1	7.36	10	No	Yes	8	0	1	0
S:S:C781	S:S:F815	4.19	10	No	No	7	7	2	2
S:S:C781	S:S:W818	6.53	10	No	Yes	7	9	2	1
S:S:F814	X:X:?1	5.39	0	No	Yes	9	0	1	0
S:S:F815	S:S:W818	4.01	10	No	Yes	7	9	2	1
S:S:F815	S:S:I819	5.02	10	No	No	7	6	2	2
S:S:I819	S:S:W818	5.87	10	No	Yes	6	9	2	1
S:S:F821	S:S:W818	7.02	10	No	Yes	9	9	1	1
S:S:W818	X:X:?1	6.72	10	Yes	Yes	9	0	1	0
S:S:A840	S:S:F821	5.55	0	No	No	9	9	2	1
S:S:F821	X:X:?1	16.16	10	No	Yes	9	0	1	0
S:S:Y825	S:S:Y829	5.96	0	No	No	9	6	1	2
S:S:Y825	X:X:?1	23.33	0	No	Yes	9	0	1	0
S:S:E837	X:X:?1	22.46	10	No	Yes	9	0	1	0
S:S:I841	S:S:V838	3.07	10	Yes	No	9	7	1	2
S:S:I841	X:X:?1	5.26	10	Yes	Yes	9	0	1	0
S:S:A844	S:S:F814	2.77	0	No	No	9	9	2	1
S:S:G774	S:S:I777	1.76	0	No	No	4	8	2	1

Statistics	Value
Average Number Of Links	12.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	12.84
Average Nodes In Shell	29.00
Average Hubs In Shell	8.00
Average Links In Shell	39.00
Average Links Mediated by Hubs In Shell	33.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	9.88
Average Number Of Links With An Hub	4.62
Average Interaction Strength	11.33
Average Nodes In Shell	25.00
Average Hubs In Shell	8.50
Average Links In Shell	31.12
Average Links Mediated by Hubs In Shell	26.75

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)