CodeYSS
Name15R-methyl-prostaglandin D2
Synonyms(5Z,13E,15R,16E)-9alpha,15-dihydroxy-15-methyl-11-oxo-12alpha-prosta-5,13,16-trien-1-oic acid
Identifier(~{Z})-7-[(1~{R},2~{R},5~{S})-2-[(~{E},3~{R})-3-methyl-3-oxidanyl-oct-1-enyl]-5-oxidanyl-3-oxidanylidene-cyclopentyl]hept-5-enoic acid
FormulaC21 H34 O5
Molecular Weight366.492
SMILESCCCCC[C@](C)(/C=C/[C@@H]1[C@H]([C@H](CC1=O)O)C/C=C\CCCC(=O)O)O
PubChem5283097
Formal Charge0
Total Atoms60
Total Chiral Atoms4
Total Bonds60
Total Aromatic Bonds0
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7M8W A Lipid Prostanoid DP2 Homo sapiens 15r-Methyl-Prostaglandin D2 Na - 2.61 2021-08-25 10.1073/pnas.2102813118

A 2D representation of the interactions of YSS in 7M8W
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L14 R:R:Y183 5.86 0 No Yes 7 4 2 1
R:R:M17 R:R:Y183 4.79 0 No Yes 7 4 2 1
R:R:H107 R:R:S83 5.58 0 Yes No 5 6 1 2
R:R:F294 R:R:S83 3.96 0 No No 6 6 2 2
R:R:F86 R:R:H107 4.53 0 No Yes 7 5 2 1
R:R:F90 R:R:H95 4.53 0 No No 5 4 1 2
L:L:?1 R:R:F90 11.35 1 Yes No 0 5 0 1
R:R:C104 R:R:W97 7.84 1 Yes Yes 9 9 2 2
R:R:H107 R:R:W97 8.46 0 Yes Yes 5 9 1 2
R:R:C182 R:R:W97 5.22 1 No Yes 9 9 1 2
R:R:C104 R:R:R170 4.18 1 Yes Yes 9 5 2 1
R:R:C104 R:R:C182 7.28 1 Yes No 9 9 2 1
R:R:K105 R:R:R170 3.71 0 No Yes 7 5 2 1
L:L:?1 R:R:H107 5.14 1 Yes Yes 0 5 0 1
R:R:R170 R:R:S108 13.18 1 Yes No 5 5 1 1
L:L:?1 R:R:S108 4 1 Yes No 0 5 0 1
R:R:F111 R:R:F112 9.65 1 Yes Yes 6 5 1 1
R:R:F111 R:R:W259 7.02 1 Yes Yes 6 8 1 2
R:R:F111 R:R:Y262 5.16 1 Yes Yes 6 7 1 1
R:R:F111 R:R:T290 3.89 1 Yes No 6 6 1 1
R:R:F111 R:R:F294 10.72 1 Yes No 6 6 1 2
L:L:?1 R:R:F111 10.54 1 Yes Yes 0 6 0 1
R:R:F112 R:R:M115 6.22 1 Yes Yes 5 8 1 2
R:R:F112 R:R:Y166 20.63 1 Yes Yes 5 4 1 2
R:R:F112 R:R:Y184 4.13 1 Yes Yes 5 4 1 1
R:R:F112 R:R:K210 3.72 1 Yes Yes 5 5 1 2
L:L:?1 R:R:F112 5.68 1 Yes Yes 0 5 0 1
R:R:K210 R:R:M115 7.2 1 Yes Yes 5 8 2 2
R:R:M115 R:R:W259 11.63 1 Yes Yes 8 8 2 2
R:R:Y166 R:R:Y184 3.97 1 Yes Yes 4 4 2 1
R:R:K210 R:R:Y166 8.36 1 Yes Yes 5 4 2 2
R:R:R170 R:R:Y184 6.17 1 Yes Yes 5 4 1 1
L:L:?1 R:R:R170 8.09 1 Yes Yes 0 5 0 1
L:L:?1 R:R:C182 4.23 1 Yes No 0 9 0 1
R:R:Y183 R:R:Y184 12.91 1 Yes Yes 4 4 1 1
R:R:E269 R:R:Y183 11.22 0 No Yes 5 4 2 1
R:R:L286 R:R:Y183 3.52 1 No Yes 5 4 1 1
L:L:?1 R:R:Y183 14.83 1 Yes Yes 0 4 0 1
R:R:Q203 R:R:Y184 14.65 0 No Yes 3 4 2 1
L:L:?1 R:R:Y184 8.59 1 Yes Yes 0 4 0 1
R:R:E269 R:R:Q203 3.82 0 No No 5 3 2 2
R:R:K210 R:R:Y262 11.94 1 Yes Yes 5 7 2 1
R:R:H263 R:R:K210 6.55 1 Yes Yes 8 5 2 2
R:R:W259 R:R:Y262 3.86 1 Yes Yes 8 7 2 1
R:R:H263 R:R:Y262 7.62 1 Yes Yes 8 7 2 1
R:R:V289 R:R:Y262 3.79 0 No Yes 7 7 2 1
L:L:?1 R:R:Y262 7.8 1 Yes Yes 0 7 0 1
L:L:?1 R:R:L286 4.61 1 Yes No 0 5 0 1
L:L:?1 R:R:P287 6.56 1 Yes No 0 4 0 1
L:L:?1 R:R:T290 9.81 1 Yes No 0 6 0 1
R:R:L286 R:R:V282 2.98 1 No No 5 4 1 2
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub7.00
Average Interaction Strength7.79
Average Nodes In Shell32.00
Average Hubs In Shell15.00
Average Links In Shell51.00
Average Links Mediated by Hubs In Shell47.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub7.00
Average Interaction Strength7.79
Average Nodes In Shell32.00
Average Hubs In Shell15.00
Average Links In Shell51.00
Average Links Mediated by Hubs In Shell47.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)