CodeYZV
Name(2S,5R)-5-[(1E,3S)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl]-1-[6-(1H-tetrazol-5-yl)hexyl]pyrrolidin-2-ol
Synonyms
Identifier
FormulaC21 H29 F2 N5 O2
Molecular Weight421.484
SMILES
PubChem169501698
Formal Charge0
Total Atoms59
Total Chiral Atoms3
Total Bonds61
Total Aromatic Bonds11
Networks2
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This ligand is also present in the following 2 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GDA A Lipid Prostanoid EP4 Homo Sapiens L902688 - Gs/Beta1/Gamma2 3.3 2024-01-03 10.1073/pnas.2216329120

A 2D representation of the interactions of YZV in 8GDA
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:P24 5.03 2 Yes Yes 0 7 0 1
L:L:?1 R:R:M27 2.17 2 Yes Yes 0 8 0 1
L:L:?1 R:R:T69 2.26 2 Yes Yes 0 8 0 1
L:L:?1 R:R:V72 10.28 2 Yes Yes 0 7 0 1
L:L:?1 R:R:S73 8.06 2 Yes Yes 0 8 0 1
L:L:?1 R:R:T76 11.3 2 Yes No 0 8 0 1
L:L:?1 R:R:Y80 6.29 2 Yes Yes 0 6 0 1
L:L:?1 R:R:L99 7.43 2 Yes Yes 0 8 0 1
L:L:?1 R:R:F102 1.87 2 Yes Yes 0 7 0 1
L:L:?1 R:R:S103 5.75 2 Yes No 0 7 0 1
L:L:?1 R:R:T168 4.52 2 Yes Yes 0 6 0 1
L:L:?1 R:R:W169 10.47 2 Yes Yes 0 5 0 1
L:L:?1 R:R:L312 5.3 2 Yes Yes 0 6 0 1
L:L:?1 R:R:I315 2.19 2 Yes No 0 6 0 1
L:L:?1 R:R:R316 4.66 2 Yes Yes 0 7 0 1
L:L:?1 R:R:S319 14.96 2 Yes No 0 8 0 1
L:L:?1 R:R:P322 3.78 2 Yes Yes 0 9 0 1
R:R:P24 R:R:V21 3.53 2 Yes No 7 6 1 2
R:R:V21 R:R:Y80 16.4 2 No Yes 6 6 2 1
R:R:I23 R:R:P24 3.39 2 No Yes 6 7 2 1
R:R:I23 R:R:M27 1.46 2 No Yes 6 8 2 1
R:R:I23 R:R:R316 6.26 2 No Yes 6 7 2 1
R:R:P24 R:R:Y80 2.78 2 Yes Yes 7 6 1 1
R:R:M27 R:R:V26 1.52 2 Yes No 8 5 1 2
R:R:M27 R:R:R316 4.96 2 Yes Yes 8 7 1 1
R:R:M27 R:R:S319 1.53 2 Yes No 8 8 1 1
R:R:I323 R:R:M27 2.92 2 Yes Yes 8 8 2 1
R:R:F28 R:R:V32 3.93 2 Yes Yes 6 7 2 2
R:R:F28 R:R:T69 2.59 2 Yes Yes 6 8 2 1
R:R:F28 R:R:L70 2.44 2 Yes Yes 6 5 2 2
R:R:F28 R:R:S73 9.25 2 Yes Yes 6 8 2 1
R:R:T69 R:R:V32 1.59 2 Yes Yes 8 7 1 2
R:R:L70 R:R:V32 2.98 2 Yes Yes 5 7 2 2
R:R:D65 R:R:T64 2.89 2 Yes Yes 9 9 2 2
R:R:F102 R:R:T64 2.59 2 Yes Yes 7 9 1 2
R:R:D65 R:R:P322 11.27 2 Yes Yes 9 9 2 1
R:R:G68 R:R:L67 1.71 2 No No 8 7 2 2
R:R:F102 R:R:L67 2.44 2 Yes No 7 7 1 2
R:R:F102 R:R:G68 9.03 2 Yes No 7 8 1 2
R:R:L70 R:R:T69 1.47 2 Yes Yes 5 8 2 1
R:R:S73 R:R:T69 3.2 2 Yes Yes 8 8 1 1
R:R:P322 R:R:T69 1.75 2 Yes Yes 9 8 1 1
R:R:S73 R:R:V72 1.62 2 Yes Yes 8 7 1 1
R:R:I98 R:R:V72 4.61 2 Yes Yes 5 7 2 1
R:R:L99 R:R:V72 4.47 2 Yes Yes 8 7 1 1
R:R:P74 R:R:S73 3.56 0 No Yes 9 8 2 1
R:R:S73 R:R:T76 1.6 2 Yes No 8 8 1 1
R:R:T168 R:R:T79 3.14 2 Yes Yes 6 7 1 2
R:R:T168 R:R:Y80 9.99 2 Yes Yes 6 6 1 1
R:R:L99 R:R:S95 3 2 Yes No 8 6 1 2
R:R:F102 R:R:I98 6.28 2 Yes Yes 7 5 1 2
R:R:F171 R:R:L99 7.31 2 Yes Yes 6 8 2 1
R:R:F101 R:R:F102 8.57 2 Yes Yes 7 7 2 1
R:R:S103 R:R:Y188 2.54 0 No No 7 7 1 2
R:R:P166 R:R:Q164 1.58 2 Yes Yes 6 7 2 2
R:R:Q164 R:R:W169 25.19 2 Yes Yes 7 5 2 1
R:R:F171 R:R:Q164 3.51 2 Yes Yes 6 7 2 2
R:R:P166 R:R:T168 8.74 2 Yes Yes 6 6 2 1
R:R:P166 R:R:W169 5.4 2 Yes Yes 6 5 2 1
R:R:L312 R:R:P166 1.64 2 Yes Yes 6 6 1 2
R:R:T168 R:R:W169 3.64 2 Yes Yes 6 5 1 1
R:R:F171 R:R:W169 4.01 2 Yes Yes 6 5 2 1
R:R:I315 R:R:W169 11.74 2 No Yes 6 5 1 1
R:R:L312 R:R:V306 1.49 2 Yes No 6 3 1 2
R:R:L312 R:R:N309 4.12 2 Yes No 6 2 1 2
R:R:I315 R:R:L312 1.43 2 No Yes 6 6 1 1
R:R:L312 R:R:R316 9.72 2 Yes Yes 6 7 1 1
R:R:N321 R:R:P322 1.63 0 No Yes 9 9 2 1
StatisticsValue
Average Number Of Links17.00
Average Number Of Links With An Hub13.00
Average Interaction Strength6.25
Average Nodes In Shell41.00
Average Hubs In Shell26.00
Average Links In Shell68.00
Average Links Mediated by Hubs In Shell66.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links15.00
Average Number Of Links With An Hub9.00
Average Interaction Strength6.89
Average Nodes In Shell35.00
Average Hubs In Shell18.00
Average Links In Shell52.50
Average Links Mediated by Hubs In Shell49.50

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)