CodeYZV
Name(2S,5R)-5-[(1E,3S)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl]-1-[6-(1H-tetrazol-5-yl)hexyl]pyrrolidin-2-ol
Synonyms
Identifier(2~{S},5~{R})-5-[(~{E},3~{S})-4,4-bis(fluoranyl)-3-oxidanyl-4-phenyl-but-1-enyl]-1-[6-(1~{H}-1,2,3,4-tetrazol-5-yl)hexyl]pyrrolidin-2-ol
FormulaC21 H29 F2 N5 O2
Molecular Weight421.484
SMILESc1ccc(cc1)C([C@H](/C=C/[C@H]2CC[C@@H](N2CCCCCCc3[nH]nnn3)O)O)(F)F
PubChem169501698
Formal Charge0
Total Atoms59
Total Chiral Atoms3
Total Bonds61
Total Aromatic Bonds11
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GDA A Lipid Prostanoid EP4 Homo Sapiens L902688 - Gs/Beta1/Gamma2 3.3 2024-01-03 10.1073/pnas.2216329120

A 2D representation of the interactions of YZV in 8GDA
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V21 R:R:Y80 11.36 0 No No 6 6 2 1
R:R:I23 R:R:P24 3.39 0 No No 6 7 2 1
R:R:I23 R:R:R316 6.26 0 No Yes 6 7 2 1
L:L:?1 R:R:P24 5.03 1 Yes No 0 7 0 1
R:R:M27 R:R:R316 4.96 0 No Yes 8 7 2 1
R:R:F28 R:R:S73 14.53 0 Yes No 6 8 2 1
R:R:D65 R:R:P322 11.27 12 Yes No 9 9 2 1
R:R:I98 R:R:V72 4.61 0 Yes No 5 7 2 1
R:R:L99 R:R:V72 4.47 1 Yes No 8 7 1 1
L:L:?1 R:R:V72 10.28 1 Yes No 0 7 0 1
R:R:P74 R:R:S73 5.34 0 No No 9 8 2 1
L:L:?1 R:R:S73 3.45 1 Yes No 0 8 0 1
L:L:?1 R:R:T76 11.3 1 Yes No 0 8 0 1
R:R:T168 R:R:T79 3.14 1 Yes No 6 7 1 2
R:R:T168 R:R:Y80 9.99 1 Yes No 6 6 1 1
L:L:?1 R:R:Y80 6.29 1 Yes No 0 6 0 1
R:R:L99 R:R:S95 3 1 Yes No 8 6 1 2
R:R:F171 R:R:L99 7.31 1 Yes Yes 6 8 2 1
L:L:?1 R:R:L99 7.43 1 Yes Yes 0 8 0 1
L:L:?1 R:R:S103 5.75 1 Yes No 0 7 0 1
R:R:Q164 R:R:W169 25.19 1 Yes Yes 7 5 2 1
R:R:F171 R:R:Q164 3.51 1 Yes Yes 6 7 2 2
R:R:P166 R:R:T168 8.74 1 No Yes 6 6 2 1
R:R:P166 R:R:W169 5.4 1 No Yes 6 5 2 1
R:R:T168 R:R:W169 3.64 1 Yes Yes 6 5 1 1
L:L:?1 R:R:T168 4.52 1 Yes Yes 0 6 0 1
R:R:F171 R:R:W169 4.01 1 Yes Yes 6 5 2 1
R:R:I315 R:R:W169 11.74 0 No Yes 6 5 2 1
L:L:?1 R:R:W169 10.47 1 Yes Yes 0 5 0 1
R:R:L312 R:R:N309 4.12 1 No No 6 2 1 2
R:R:L312 R:R:R316 9.72 1 No Yes 6 7 1 1
L:L:?1 R:R:L312 5.3 1 Yes No 0 6 0 1
L:L:?1 R:R:R316 4.66 1 Yes Yes 0 7 0 1
L:L:?1 R:R:S319 14.96 1 Yes No 0 8 0 1
L:L:?1 R:R:P322 3.78 1 Yes No 0 9 0 1
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.17
Average Nodes In Shell28.00
Average Hubs In Shell10.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell31.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.17
Average Nodes In Shell28.00
Average Hubs In Shell10.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell31.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)