CodeZ2C
Name4-({2-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]butyl}cyclopentyl]ethyl}sulfanyl)butanoic acid
Synonyms
Identifier4-[2-[(1~{R},2~{R},3~{R},5~{S})-2-[(3~{S})-4-[3-(methoxymethyl)phenyl]-3-oxidanyl-butyl]-3,5-bis(oxidanyl)cyclopentyl]ethylsulfanyl]butanoic acid
FormulaC23 H36 O6 S
Molecular Weight440.593
SMILESCOCc1cccc(c1)C[C@H](CC[C@H]2[C@@H](C[C@@H]([C@@H]2CCSCCCC(=O)O)O)O)O
PubChem169501697
Formal Charge0
Total Atoms66
Total Chiral Atoms5
Total Bonds67
Total Aromatic Bonds6
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GD9 A Lipid Prostanoid EP4 Homo Sapiens Rivenprost - Gs/Beta1/Gamma2 3.2 2024-01-03 10.1073/pnas.2216329120

A 2D representation of the interactions of Z2C in 8GD9
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F28 R:R:S73 10.57 0 No Yes 6 8 2 1
R:R:D65 R:R:F102 8.36 0 Yes Yes 9 7 2 1
R:R:F102 R:R:G68 4.52 3 Yes No 7 8 1 2
L:L:?1 R:R:T69 7.12 3 Yes No 0 8 0 1
R:R:L99 R:R:V72 5.96 0 No No 8 7 1 2
R:R:P74 R:R:S73 3.56 0 No Yes 9 8 2 1
L:L:?1 R:R:S73 7.26 3 Yes Yes 0 8 0 1
L:L:?1 R:R:T76 8.01 3 Yes No 0 8 0 1
R:R:T79 R:R:Y80 4.99 3 No No 7 6 2 2
R:R:T168 R:R:T79 3.14 3 Yes No 6 7 1 2
R:R:T168 R:R:Y80 11.24 3 Yes No 6 6 1 2
R:R:F102 R:R:P322 7.22 3 Yes Yes 7 9 1 1
L:L:?1 R:R:F102 25.01 3 Yes Yes 0 7 0 1
L:L:?1 R:R:S103 11.79 3 Yes No 0 7 0 1
R:R:P166 R:R:Q164 3.16 3 Yes Yes 6 7 2 2
R:R:Q164 R:R:W169 31.76 3 Yes Yes 7 5 2 1
R:R:P166 R:R:T168 8.74 3 Yes Yes 6 6 2 1
R:R:P166 R:R:W169 4.05 3 Yes Yes 6 5 2 1
R:R:L312 R:R:P166 4.93 3 Yes Yes 6 6 1 2
R:R:T168 R:R:W169 6.06 3 Yes Yes 6 5 1 1
L:L:?1 R:R:T168 4.45 3 Yes Yes 0 6 0 1
R:R:F171 R:R:W169 4.01 3 Yes Yes 6 5 2 1
R:R:L312 R:R:W169 4.56 3 Yes Yes 6 5 1 1
R:R:I315 R:R:W169 8.22 3 No Yes 6 5 1 1
L:L:?1 R:R:W169 8.26 3 Yes Yes 0 5 0 1
R:R:I315 R:R:L288 2.85 3 No No 6 7 1 2
R:R:L312 R:R:Q313 5.32 3 Yes No 6 3 1 2
R:R:L312 R:R:R316 4.86 3 Yes No 6 7 1 1
L:L:?1 R:R:L312 5.02 3 Yes Yes 0 6 0 1
L:L:?1 R:R:I315 6.04 3 Yes No 0 6 0 1
L:L:?1 R:R:R316 11.74 3 Yes No 0 7 0 1
R:R:P322 R:R:S319 3.56 3 Yes No 9 8 1 1
L:L:?1 R:R:S319 19.05 3 Yes No 0 8 0 1
R:R:N321 R:R:P322 4.89 0 Yes Yes 9 9 2 1
L:L:?1 R:R:P322 8.93 3 Yes Yes 0 9 0 1
L:L:?1 R:R:L99 2.51 3 Yes No 0 8 0 1
R:R:I77 R:R:S73 1.55 0 No Yes 6 8 2 1
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub6.00
Average Interaction Strength9.63
Average Nodes In Shell28.00
Average Hubs In Shell12.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell34.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub6.00
Average Interaction Strength9.63
Average Nodes In Shell28.00
Average Hubs In Shell12.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell34.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)