Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 6C1Q | A | Peptide | Complement peptide | C5a1 | Homo sapiens | PMX53 | NDT9513727 | - | 2.9 | 2018-05-30 | 10.1038/s41594-018-0067-z |
![](/psngpcr/ligands/ZAL/ZAL_6C1Q_L_L_4.png)
A 2D representation of the interactions of ZAL in 6C1Q colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D37 | R:R:I96 | 4.2 | 6 | No | Yes | 4 | 5 | 2 | 1 | R:R:I96 | R:R:L41 | 4.28 | 0 | Yes | Yes | 5 | 5 | 1 | 2 | R:R:I91 | R:R:W102 | 3.52 | 1 | No | Yes | 6 | 8 | 2 | 1 | R:R:F104 | R:R:I91 | 13.82 | 1 | No | No | 7 | 6 | 2 | 2 | L:L:W5 | R:R:L92 | 6.83 | 0 | Yes | No | 0 | 6 | 1 | 2 | R:R:S95 | R:R:W102 | 4.94 | 1 | No | Yes | 4 | 8 | 1 | 1 | L:L:?4 | R:R:S95 | 6.97 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:I96 | R:R:S283 | 4.64 | 0 | Yes | No | 5 | 4 | 1 | 2 | L:L:?4 | R:R:H100 | 3.58 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:F104 | R:R:W102 | 20.04 | 1 | No | Yes | 7 | 8 | 2 | 1 | R:R:C109 | R:R:W102 | 5.22 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:C188 | R:R:W102 | 14.37 | 1 | No | Yes | 9 | 8 | 2 | 1 | L:L:?4 | R:R:W102 | 3.17 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:C109 | R:R:C188 | 7.28 | 1 | Yes | No | 9 | 9 | 2 | 2 | R:R:P113 | R:R:R175 | 11.53 | 0 | No | Yes | 6 | 5 | 2 | 1 | L:L:W5 | R:R:P113 | 5.4 | 0 | Yes | No | 0 | 6 | 1 | 2 | R:R:R175 | R:R:S114 | 3.95 | 1 | Yes | No | 5 | 5 | 1 | 2 | R:R:C188 | R:R:R175 | 4.18 | 1 | No | Yes | 9 | 5 | 2 | 1 | R:R:G189 | R:R:R175 | 3 | 1 | Yes | Yes | 4 | 5 | 1 | 1 | L:L:?4 | R:R:R175 | 10.15 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:F1 | R:R:G189 | 3.01 | 1 | Yes | Yes | 0 | 4 | 2 | 1 | L:L:?2 | R:R:G189 | 3.18 | 1 | Yes | Yes | 0 | 4 | 1 | 1 | L:L:?4 | R:R:G189 | 3.18 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:?2 | R:R:V190 | 4.16 | 1 | Yes | No | 0 | 5 | 1 | 2 | L:L:W5 | R:R:D282 | 6.7 | 0 | Yes | No | 0 | 4 | 1 | 2 | L:L:W5 | R:R:V286 | 17.16 | 0 | Yes | No | 0 | 5 | 1 | 2 | L:L:?2 | L:L:F1 | 13.59 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | L:L:?2 | L:L:P3 | 15.27 | 1 | Yes | No | 0 | 0 | 1 | 1 | L:L:?2 | L:L:?4 | 3.59 | 1 | Yes | Yes | 0 | 0 | 1 | 0 | L:L:?4 | L:L:P3 | 4.57 | 1 | Yes | No | 0 | 0 | 0 | 1 | L:L:?4 | L:L:W5 | 17.98 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?4 | R:R:I96 | 2.65 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?2 | R:R:K279 | 2.62 | 1 | Yes | No | 0 | 4 | 1 | 2 | R:R:A108 | R:R:W102 | 2.59 | 0 | No | Yes | 5 | 8 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 6.20 | Average Nodes In Shell | 26.00 | Average Hubs In Shell | 10.00 | Average Links In Shell | 34.00 | Average Links Mediated by Hubs In Shell | 33.00 |
| ![](/psngpcr/ligands/ZAL/ZAL_6C1Q_L_L_4_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ZAL/ZAL_6C1Q_L_L_4_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 6C1R | A | Peptide | Complement peptide | C5a1 | Homo sapiens | PMX53 | Avacopan; Na | - | 2.2 | 2018-05-30 | 10.1038/s41594-018-0067-z |
![](/psngpcr/ligands/ZAL/ZAL_6C1R_L_L_4.png)
A 2D representation of the interactions of ZAL in 6C1R colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D37 | R:R:H100 | 6.3 | 0 | No | No | 4 | 4 | 2 | 1 | R:R:I96 | R:R:L41 | 7.14 | 0 | Yes | No | 5 | 5 | 1 | 2 | L:L:W5 | R:R:L92 | 6.83 | 0 | Yes | No | 0 | 6 | 1 | 2 | R:R:S95 | R:R:W102 | 6.18 | 0 | No | Yes | 4 | 8 | 1 | 2 | L:L:?4 | R:R:S95 | 5.58 | 0 | Yes | No | 0 | 4 | 0 | 1 | R:R:I96 | R:R:S283 | 4.64 | 0 | Yes | No | 5 | 4 | 1 | 2 | L:L:?4 | R:R:I96 | 3.98 | 0 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:C188 | R:R:W102 | 16.98 | 5 | No | Yes | 9 | 8 | 2 | 2 | R:R:P113 | R:R:R175 | 12.97 | 0 | No | Yes | 6 | 5 | 2 | 1 | L:L:W5 | R:R:P113 | 5.4 | 0 | Yes | No | 0 | 6 | 1 | 2 | R:R:C188 | R:R:R175 | 4.18 | 5 | No | Yes | 9 | 5 | 2 | 1 | L:L:?4 | R:R:R175 | 10.15 | 0 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?4 | R:R:G189 | 6.35 | 0 | Yes | No | 0 | 4 | 0 | 1 | L:L:?2 | R:R:V190 | 6.93 | 3 | Yes | No | 0 | 5 | 1 | 2 | L:L:?2 | R:R:K279 | 6.56 | 3 | Yes | No | 0 | 4 | 1 | 2 | L:L:W5 | R:R:D282 | 7.82 | 0 | Yes | No | 0 | 4 | 1 | 2 | L:L:W5 | R:R:V286 | 22.07 | 0 | Yes | No | 0 | 5 | 1 | 2 | L:L:?2 | L:L:F1 | 19.26 | 3 | Yes | Yes | 0 | 0 | 1 | 2 | L:L:F1 | L:L:P3 | 4.33 | 3 | Yes | No | 0 | 0 | 2 | 2 | L:L:?2 | L:L:P3 | 15.27 | 3 | Yes | No | 0 | 0 | 1 | 2 | L:L:?2 | L:L:?4 | 4.78 | 3 | Yes | Yes | 0 | 0 | 1 | 0 | L:L:?4 | L:L:W5 | 21.15 | 0 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?4 | R:R:H100 | 3.58 | 0 | Yes | No | 0 | 4 | 0 | 1 | R:R:R175 | R:R:S114 | 2.64 | 0 | Yes | No | 5 | 5 | 1 | 2 | R:R:I96 | R:R:L33 | 1.43 | 0 | Yes | No | 5 | 4 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 7.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 7.94 | Average Nodes In Shell | 23.00 | Average Hubs In Shell | 7.00 | Average Links In Shell | 25.00 | Average Links Mediated by Hubs In Shell | 24.00 |
| ![](/psngpcr/ligands/ZAL/ZAL_6C1R_L_L_4_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ZAL/ZAL_6C1R_L_L_4_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7Y65 | A | Peptide | Complement peptide | C5A1 | Homo Sapiens | C5a peptide | - | Gi1/Beta1/Gamma2 | 3.2 | 2023-03-01 | 10.1038/s41422-023-00779-2 |
![](/psngpcr/ligands/ZAL/ZAL_7Y65_L_L_4.png)
A 2D representation of the interactions of ZAL in 7Y65 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?4 | L:L:?5 | 25.28 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?4 | L:L:?6 | 2.06 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?4 | R:R:L92 | 6.43 | 2 | Yes | No | 0 | 6 | 0 | 1 | L:L:?4 | R:R:P113 | 3.05 | 2 | Yes | No | 0 | 6 | 0 | 1 | L:L:?4 | R:R:R175 | 5.64 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?5 | L:L:?6 | 31.23 | 2 | Yes | Yes | 0 | 0 | 1 | 1 | L:L:?5 | R:R:L92 | 2.37 | 2 | Yes | No | 0 | 6 | 1 | 1 | L:L:?5 | R:R:I116 | 6.1 | 2 | Yes | No | 0 | 6 | 1 | 2 | L:L:?5 | R:R:L117 | 2.37 | 2 | Yes | No | 0 | 4 | 1 | 2 | L:L:?5 | R:R:V286 | 3.82 | 2 | Yes | Yes | 0 | 5 | 1 | 2 | L:L:?6 | R:R:V190 | 3.57 | 2 | Yes | No | 0 | 5 | 1 | 2 | L:L:?6 | R:R:Y258 | 15.93 | 2 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:?6 | R:R:D282 | 10.85 | 2 | Yes | No | 0 | 4 | 1 | 2 | L:L:?6 | R:R:V286 | 2.38 | 2 | Yes | Yes | 0 | 5 | 1 | 2 | R:R:L89 | R:R:L92 | 4.15 | 0 | No | No | 7 | 6 | 2 | 1 | R:R:L112 | R:R:P113 | 3.28 | 0 | No | No | 5 | 6 | 2 | 1 | R:R:P113 | R:R:R175 | 8.65 | 2 | No | Yes | 6 | 5 | 1 | 1 | R:R:R175 | R:R:S171 | 2.64 | 2 | Yes | No | 5 | 5 | 1 | 2 | R:R:C188 | R:R:R175 | 4.18 | 0 | No | Yes | 9 | 5 | 2 | 1 | R:R:R175 | R:R:V190 | 2.62 | 2 | Yes | No | 5 | 5 | 1 | 2 | R:R:V286 | R:R:Y258 | 5.05 | 2 | Yes | Yes | 5 | 7 | 2 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 5.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 8.49 | Average Nodes In Shell | 16.00 | Average Hubs In Shell | 6.00 | Average Links In Shell | 21.00 | Average Links Mediated by Hubs In Shell | 19.00 |
| ![](/psngpcr/ligands/ZAL/ZAL_7Y65_L_L_4_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ZAL/ZAL_7Y65_L_L_4_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7Y67 | A | Peptide | Complement peptide | C5A1 | Homo Sapiens | C089 peptide | - | Gi1/Beta1/Gamma2 | 2.8 | 2023-03-01 | 10.1038/s41422-023-00779-2 |
![](/psngpcr/ligands/ZAL/ZAL_7Y67_L_L_4.png)
A 2D representation of the interactions of ZAL in 7Y67 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?4 | R:R:I96 | 2.65 | 0 | Yes | No | 0 | 5 | 0 | 1 | L:L:?4 | R:R:H100 | 14.33 | 0 | Yes | No | 0 | 4 | 0 | 1 | R:R:D282 | R:R:V286 | 4.38 | 9 | Yes | Yes | 4 | 5 | 2 | 2 | L:L:W5 | R:R:D282 | 5.58 | 9 | Yes | Yes | 0 | 4 | 1 | 2 | L:L:?6 | R:R:D282 | 8.68 | 9 | Yes | Yes | 0 | 4 | 2 | 2 | L:L:W5 | R:R:V286 | 22.07 | 9 | Yes | Yes | 0 | 5 | 1 | 2 | L:L:?6 | R:R:V286 | 5.95 | 9 | Yes | Yes | 0 | 5 | 2 | 2 | L:L:?4 | L:L:W5 | 4.23 | 0 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?6 | L:L:W5 | 9.1 | 9 | Yes | Yes | 0 | 0 | 2 | 1 | L:L:?4 | R:R:L92 | 1.29 | 0 | Yes | No | 0 | 6 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 4.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 5.62 | Average Nodes In Shell | 8.00 | Average Hubs In Shell | 5.00 | Average Links In Shell | 10.00 | Average Links Mediated by Hubs In Shell | 10.00 |
| ![](/psngpcr/ligands/ZAL/ZAL_7Y67_L_L_4_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ZAL/ZAL_7Y67_L_L_4_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8HPT | A | Peptide | Complement peptide | C5a1 | Mus Musculus | C5a anaphylatoxin C-terminal peptide | - | Go/Beta1/Gamma2 | 3.39 | 2023-10-18 | 10.1016/j.cell.2023.09.020 |
![](/psngpcr/ligands/ZAL/ZAL_8HPT_L_L_4.png)
A 2D representation of the interactions of ZAL in 8HPT colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?5 | R:R:L92 | 3.55 | 4 | Yes | No | 0 | 6 | 1 | 2 | R:R:C109 | R:R:Y178 | 5.38 | 0 | No | No | 9 | 1 | 2 | 1 | R:R:I110 | R:R:R175 | 3.76 | 0 | No | Yes | 7 | 4 | 2 | 1 | R:R:P113 | R:R:R175 | 8.65 | 0 | No | Yes | 5 | 4 | 2 | 1 | L:L:?5 | R:R:I116 | 4.88 | 4 | Yes | No | 0 | 6 | 1 | 2 | L:L:?5 | R:R:L117 | 4.74 | 4 | Yes | No | 0 | 4 | 1 | 2 | L:L:?4 | R:R:R175 | 5.64 | 4 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:?5 | R:R:R175 | 3.12 | 4 | Yes | Yes | 0 | 4 | 1 | 1 | L:L:?4 | R:R:Y178 | 8.71 | 4 | Yes | No | 0 | 1 | 0 | 1 | L:L:?5 | R:R:Y259 | 4.01 | 4 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:?6 | R:R:Y259 | 17.81 | 4 | Yes | Yes | 0 | 7 | 2 | 2 | L:L:P3 | R:R:E280 | 6.29 | 0 | No | No | 0 | 3 | 1 | 2 | L:L:?5 | R:R:V287 | 6.37 | 4 | Yes | No | 0 | 5 | 1 | 2 | L:L:K2 | L:L:P3 | 5.02 | 0 | No | No | 0 | 0 | 2 | 1 | L:L:?4 | L:L:P3 | 4.57 | 4 | Yes | No | 0 | 0 | 0 | 1 | L:L:?4 | L:L:?5 | 25.28 | 4 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?5 | L:L:?6 | 28.39 | 4 | Yes | Yes | 0 | 0 | 1 | 2 | R:R:R175 | R:R:S171 | 2.64 | 4 | Yes | No | 4 | 5 | 1 | 2 | L:L:?4 | R:R:N100 | 2.55 | 4 | Yes | No | 0 | 3 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 5.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 9.35 | Average Nodes In Shell | 18.00 | Average Hubs In Shell | 5.00 | Average Links In Shell | 19.00 | Average Links Mediated by Hubs In Shell | 16.00 |
| ![](/psngpcr/ligands/ZAL/ZAL_8HPT_L_L_4_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ZAL/ZAL_8HPT_L_L_4_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|