CodeZD7
Name5,7-diethyl-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-3,4-dihydro-1,6-naphthyridin-2(1H)-one
Synonyms
Identifier5,7-diethyl-1-[[4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]-3,4-dihydro-1,6-naphthyridin-2-one
FormulaC26 H26 N6 O
Molecular Weight438.524
SMILESCCc1cc2c(c(n1)CC)CCC(=O)N2Cc3ccc(cc3)c4ccccc4c5[nH]nnn5
PubChem4673492
Formal Charge0
Total Atoms59
Total Chiral Atoms0
Total Bonds63
Total Aromatic Bonds23
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4YAY A Peptide Angiotensin AT1 Homo sapiens ZD-7155 - - 2.9 2015-04-22 10.1016/j.cell.2015.04.011

A 2D representation of the interactions of ZD7 in 4YAY
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I31 R:R:Y35 8.46 0 Yes Yes 6 7 2 1
R:R:I31 R:R:T88 7.6 0 Yes No 6 5 2 1
R:R:L81 R:R:Y35 12.89 0 No Yes 8 7 2 1
R:R:A85 R:R:Y35 4 0 No Yes 7 7 2 1
R:R:C289 R:R:Y35 6.72 0 No Yes 5 7 2 1
L:L:?1 R:R:Y35 12.04 1 Yes Yes 0 7 0 1
R:R:F77 R:R:V108 6.55 1 Yes Yes 6 6 2 1
R:R:F77 R:R:N111 14.5 1 Yes No 6 8 2 2
R:R:F77 R:R:Y292 15.47 1 Yes Yes 6 7 2 1
R:R:W84 R:R:Y87 4.82 1 Yes Yes 7 5 1 2
R:R:W84 R:R:W94 11.25 1 Yes Yes 7 9 1 2
R:R:A104 R:R:W84 3.89 0 No Yes 6 7 2 1
R:R:S105 R:R:W84 4.94 1 No Yes 5 7 1 1
R:R:V108 R:R:W84 3.68 1 Yes Yes 6 7 1 1
R:R:C180 R:R:W84 3.92 1 No Yes 9 7 2 1
L:L:?1 R:R:W84 29.58 1 Yes Yes 0 7 0 1
R:R:W94 R:R:Y87 10.61 1 Yes Yes 9 5 2 2
L:L:?1 R:R:T88 3.56 1 Yes No 0 5 0 1
R:R:C180 R:R:W94 10.45 1 No Yes 9 9 2 2
R:R:R167 R:R:S105 15.81 1 No No 5 5 1 1
L:L:?1 R:R:S105 3.63 1 Yes No 0 5 0 1
R:R:V108 R:R:Y292 5.05 1 Yes Yes 6 7 1 1
L:L:?1 R:R:V108 15.3 1 Yes Yes 0 6 0 1
R:R:S109 R:R:S160 3.26 0 No No 4 7 1 2
L:L:?1 R:R:S109 13.6 1 Yes No 0 4 0 1
R:R:N111 R:R:Y292 5.81 1 No Yes 8 7 2 1
R:R:F182 R:R:H166 13.58 1 Yes No 4 4 1 2
R:R:F182 R:R:R167 4.28 1 Yes No 4 5 1 1
L:L:?1 R:R:R167 24.22 1 Yes No 0 5 0 1
R:R:F182 R:R:Y184 10.32 1 Yes No 4 4 1 2
L:L:?1 R:R:F182 5.15 1 Yes Yes 0 4 0 1
R:R:W253 R:R:Y292 8.68 0 Yes Yes 8 7 2 1
R:R:H256 R:R:I288 10.61 0 No No 6 6 2 1
L:L:?1 R:R:I288 8.62 1 Yes No 0 6 0 1
L:L:?1 R:R:Y292 3.54 1 Yes Yes 0 7 0 1
R:R:F182 R:R:P162 2.89 1 Yes No 4 6 1 2
L:L:?1 R:R:A163 1.9 1 Yes No 0 4 0 1
R:R:A106 R:R:A163 1.79 0 No No 5 4 2 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub5.00
Average Interaction Strength11.01
Average Nodes In Shell29.00
Average Hubs In Shell11.00
Average Links In Shell38.00
Average Links Mediated by Hubs In Shell34.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub5.00
Average Interaction Strength11.01
Average Nodes In Shell29.00
Average Hubs In Shell11.00
Average Links In Shell38.00
Average Links Mediated by Hubs In Shell34.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)