CodeZI5
Name(5Z,8Z,11Z,13S,14Z)-N-[(2R)-1-hydroxypropan-2-yl]-13-methylicosa-5,8,11,14-tetraenamide
Synonyms
Identifier(5~{Z},8~{Z},11~{Z},13~{S},14~{Z})-13-methyl-~{N}-[(2~{R})-1-oxidanylpropan-2-yl]icosa-5,8,11,14-tetraenamide
FormulaC24 H41 N O2
Molecular Weight375.588
SMILESCCCCC/C=C\[C@H](C)/C=C\C/C=C\C/C=C\CCCC(=O)N[C@H](C)CO
PubChem145964903
Formal Charge0
Total Atoms68
Total Chiral Atoms2
Total Bonds67
Total Aromatic Bonds0
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GHV A Lipid Cannabinoid CB1 Homo sapiens PubChem 145964903 - Gi1/Beta1/Gamma2 2.8 2023-05-24 10.1038/s41467-023-37864-4

A 2D representation of the interactions of ZI5 in 8GHV
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F177 R:R:M109 9.95 3 Yes No 4 3 1 2
R:R:K376 R:R:V110 12.14 0 No No 2 3 1 2
R:R:F174 R:R:I119 3.77 3 Yes Yes 5 5 1 2
R:R:F170 R:R:F174 6.43 3 No Yes 7 5 1 1
R:R:F170 R:R:S383 2.64 3 No No 7 6 1 1
L:L:?1 R:R:F170 5.79 3 Yes No 0 7 0 1
R:R:K192 R:R:S173 4.59 0 No No 6 4 2 1
L:L:?1 R:R:S173 2.38 3 Yes No 0 4 0 1
R:R:F174 R:R:H178 10.18 3 Yes No 5 4 1 1
L:L:?1 R:R:F174 2.9 3 Yes Yes 0 5 0 1
R:R:F177 R:R:H178 9.05 3 Yes No 4 4 1 1
R:R:F177 R:R:F189 2.14 3 Yes No 4 9 1 2
L:L:?1 R:R:F177 6.76 3 Yes Yes 0 4 0 1
L:L:?1 R:R:H178 11.21 3 Yes No 0 4 0 1
R:R:G194 R:R:L193 1.71 0 Yes Yes 6 4 2 1
R:R:F268 R:R:L193 4.87 3 Yes Yes 5 4 1 1
R:R:I271 R:R:L193 2.85 3 No Yes 3 4 2 1
L:L:?1 R:R:L193 4.39 3 Yes Yes 0 4 0 1
R:R:G194 R:R:T197 3.64 0 Yes Yes 6 6 2 1
R:R:F200 R:R:V196 2.62 0 No No 7 7 1 2
R:R:T197 R:R:Y275 3.75 3 Yes Yes 6 7 1 1
R:R:T197 R:R:W279 2.43 3 Yes Yes 6 6 1 1
L:L:?1 R:R:T197 8.18 3 Yes Yes 0 6 0 1
R:R:C386 R:R:F200 5.59 0 No No 7 7 2 1
L:L:?1 R:R:F200 5.79 3 Yes No 0 7 0 1
R:R:T201 R:R:W279 2.43 0 No Yes 6 6 2 1
R:R:I247 R:R:Y275 3.63 0 No Yes 5 7 2 1
R:R:P251 R:R:Y275 8.34 0 No Yes 6 7 2 1
R:R:I267 R:R:S265 3.1 3 Yes No 4 4 1 2
R:R:F268 R:R:S265 2.64 3 Yes No 5 4 1 2
R:R:I271 R:R:S265 3.1 3 No No 3 4 2 2
R:R:F268 R:R:I267 5.02 3 Yes Yes 5 4 1 1
R:R:D366 R:R:I267 11.2 3 No Yes 4 4 2 1
R:R:F379 R:R:I267 5.02 3 Yes Yes 4 4 1 1
L:L:?1 R:R:I267 6.79 3 Yes Yes 0 4 0 1
R:R:F268 R:R:I271 2.51 3 Yes No 5 3 1 2
R:R:F268 R:R:L276 2.44 3 Yes No 5 5 1 2
R:R:F268 R:R:F379 4.29 3 Yes Yes 5 4 1 1
L:L:?1 R:R:F268 7.72 3 Yes Yes 0 5 0 1
L:L:?1 R:R:Y275 1.86 3 Yes Yes 0 7 0 1
R:R:I280 R:R:L276 4.28 3 Yes No 5 5 2 2
R:R:I280 R:R:W279 3.52 3 Yes Yes 5 6 2 1
R:R:T283 R:R:W279 10.92 0 No Yes 8 6 2 1
R:R:W279 R:R:W356 1.87 3 Yes Yes 6 8 1 2
R:R:L360 R:R:W279 4.56 3 No Yes 7 6 2 1
R:R:M363 R:R:W279 3.49 3 Yes Yes 6 6 1 1
L:L:?1 R:R:W279 6.32 3 Yes Yes 0 6 0 1
R:R:I280 R:R:L360 4.28 3 Yes No 5 7 2 2
R:R:I280 R:R:M363 7.29 3 Yes Yes 5 6 2 1
R:R:C386 R:R:W356 5.22 0 No Yes 7 8 2 2
R:R:L359 R:R:M363 4.24 3 No Yes 7 6 1 1
R:R:F379 R:R:L359 4.87 3 Yes No 4 7 1 1
L:L:?1 R:R:L359 2.19 3 Yes No 0 7 0 1
R:R:F379 R:R:I362 8.79 3 Yes No 4 4 1 2
R:R:F379 R:R:M363 4.98 3 Yes Yes 4 6 1 1
L:L:?1 R:R:M363 3.36 3 Yes Yes 0 6 0 1
L:L:?1 R:R:K376 3.35 3 Yes No 0 2 0 1
R:R:F379 R:R:S383 3.96 3 Yes No 4 6 1 1
L:L:?1 R:R:F379 1.93 3 Yes Yes 0 4 0 1
L:L:?1 R:R:S383 4.76 3 Yes No 0 6 0 1
L:L:?1 R:R:A380 1.25 3 Yes No 0 4 0 1
StatisticsValue
Average Number Of Links18.00
Average Number Of Links With An Hub10.00
Average Interaction Strength4.83
Average Nodes In Shell39.00
Average Hubs In Shell15.00
Average Links In Shell61.00
Average Links Mediated by Hubs In Shell55.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links18.00
Average Number Of Links With An Hub10.00
Average Interaction Strength4.83
Average Nodes In Shell39.00
Average Hubs In Shell15.00
Average Links In Shell61.00
Average Links Mediated by Hubs In Shell55.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)