CodeZIT
NameAzithromycin
SynonymsAzithromycine
Identifier
FormulaC38 H72 N2 O12
Molecular Weight748.984
SMILES
PubChem447043
Formal Charge0
Total Atoms124
Total Chiral Atoms18
Total Bonds126
Total Aromatic Bonds0
Networks2
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This ligand is also present in the following 2 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JMD A Peptide Motilin Motilin Homo Sapiens Azithromycin - chim(Gs-CtGq)/Beta1/Gamma2 2.74 2025-05-28 doi.org/10.1016/j.celrep.2025.115329

A 2D representation of the interactions of ZIT in 9JMD
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D94 6.96 2 Yes Yes 0 7 0 1
L:L:?1 R:R:R97 6.23 2 Yes Yes 0 6 0 1
L:L:?1 R:R:L98 5.32 2 Yes No 0 6 0 1
L:L:?1 R:R:L115 7.1 2 Yes No 0 5 0 1
L:L:?1 R:R:E119 3.4 2 Yes Yes 0 6 0 1
L:L:?1 R:R:E234 11.89 2 Yes Yes 0 4 0 1
L:L:?1 R:R:F314 5.46 2 Yes Yes 0 6 0 1
L:L:?1 R:R:Y321 6.76 2 Yes No 0 5 0 1
L:L:?1 R:R:Q334 3.41 2 Yes No 0 5 0 1
L:L:?1 R:R:L341 8.87 2 Yes No 0 6 0 1
R:R:P32 R:R:Q334 4.74 0 No No 3 5 2 1
R:R:L38 R:R:L98 4.15 24 Yes No 6 6 2 1
R:R:D94 R:R:R97 5.96 2 Yes Yes 7 6 1 1
R:R:D94 R:R:L341 6.79 2 Yes No 7 6 1 1
R:R:D94 R:R:Y345 4.6 2 Yes Yes 7 8 1 2
R:R:R97 R:R:W104 9 2 Yes Yes 6 8 1 2
R:R:L115 R:R:R97 3.64 2 No Yes 5 6 1 1
R:R:I338 R:R:L98 4.28 0 No No 6 6 2 1
R:R:R102 R:R:R233 20.26 2 No Yes 6 4 2 2
R:R:E234 R:R:R102 16.28 2 Yes No 4 6 1 2
R:R:R102 R:R:R236 4.26 2 No Yes 6 5 2 2
R:R:L115 R:R:S114 4.5 2 No No 5 6 1 2
R:R:E119 R:R:Y123 11.22 2 Yes Yes 6 7 1 2
R:R:E119 R:R:F173 13.99 2 Yes No 6 5 1 2
R:R:E119 R:R:R318 6.98 2 Yes Yes 6 7 1 2
R:R:F173 R:R:Y123 4.13 2 No Yes 5 7 2 2
R:R:R318 R:R:Y123 4.12 2 Yes Yes 7 7 2 2
R:R:E234 R:R:R233 4.65 2 Yes Yes 4 4 1 2
R:R:R233 R:R:R236 10.66 2 Yes Yes 4 5 2 2
R:R:E234 R:R:R236 11.63 2 Yes Yes 4 5 1 2
R:R:F314 R:R:W311 5.01 2 Yes Yes 6 8 1 2
R:R:F344 R:R:W311 4.01 2 Yes Yes 9 8 2 2
R:R:F314 R:R:H315 9.05 2 Yes No 6 8 1 2
R:R:F314 R:R:R318 9.62 2 Yes Yes 6 7 1 2
R:R:F314 R:R:F344 4.29 2 Yes Yes 6 9 1 2
R:R:H315 R:R:R318 7.9 2 No Yes 8 7 2 2
R:R:M330 R:R:Q334 8.16 0 No No 4 5 2 1
R:R:L341 R:R:Y345 8.21 2 No Yes 6 8 1 2
R:R:F344 R:R:Y345 12.38 2 Yes Yes 9 8 2 2
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub5.00
Average Interaction Strength6.54
Average Nodes In Shell27.00
Average Hubs In Shell15.00
Average Links In Shell39.00
Average Links Mediated by Hubs In Shell35.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub4.00
Average Interaction Strength6.93
Average Nodes In Shell23.50
Average Hubs In Shell12.50
Average Links In Shell33.00
Average Links Mediated by Hubs In Shell30.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)