Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 9.646671220
2M:M:?1 9.868331210
3R:R:F70 3.938507
4R:R:M81 3.09407
5R:R:I96 3.37405
6R:R:Y97 6.522507
7R:R:N100 9.602549
8R:R:T111 4.215427
9R:R:M112 7.902507
10R:R:W124 9.60167628
11R:R:F126 11.062507
12R:R:Y140 7.2475405
13R:R:T144 7.08447
14R:R:R156 6.68167669
15R:R:Y157 6.876507
16R:R:W183 9.795449
17R:R:V189 4.3675405
18R:R:F214 6.828506
19R:R:W222 8.56477
20R:R:K227 7.38404
21R:R:F235 7.4275408
22R:R:Y246 8.7825408
23R:R:R271 7.085407
24R:R:F283 9.378529
25R:R:W287 7.42375828
26R:R:I316 6.96425
27R:R:Y320 10.5725426
28R:R:N322 7.86429
29R:R:N326 6.8425409
30R:R:Y330 7.1775409
31R:R:D334 8.7025408
32R:R:F337 8.014558
33R:R:F341 6.235406
34R:R:F346 3.482504
35S:S:V69 3.9475407
36S:S:F70 4.234507
37S:S:Y97 6.4637
38S:S:D105 7.945419
39S:S:T111 4.455417
40S:S:M112 9.28407
41S:S:W124 9.49571718
42S:S:F126 10.6967607
43S:S:Y140 6.7225405
44S:S:F143 7.2375406
45S:S:T144 7.7275407
46S:S:R156 5.84667639
47S:S:Y157 7.2525497
48S:S:C161 5.3675497
49S:S:H162 6.94496
50S:S:R170 6.62636
51S:S:F214 6.198506
52S:S:L224 2.7375403
53S:S:K227 8.1825404
54S:S:F235 7.7225408
55S:S:Y246 10.5725408
56S:S:R257 7.5275404
57S:S:F283 10.162519
58S:S:W287 7.26667618
59S:S:F293 4.1625405
60S:S:N322 6.682519
61S:S:N326 6.026519
62S:S:Y330 7.005409
63S:S:F337 7.00333688
64S:S:F341 5.2406
65S:S:F346 6.545404
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:Y320 63.531113.7YesYes206
2R:R:M112 R:R:Y320 72.866617.96YesYes076
3R:R:F70 R:R:M112 73.63374.98YesYes077
4R:R:F70 S:S:S67 90.52743.96YesNo074
5R:R:S67 S:S:S67 90.58476.52NoNo044
6R:R:S67 S:S:F70 90.68883.96NoYes047
7S:S:F70 S:S:M112 91.62436.22YesYes077
8S:S:M112 S:S:Y320 10017.96YesNo076
9M:M:?1 S:S:Y320 98.49715.98YesNo106
10M:M:?1 S:S:Q115 12.61397.78YesNo007
11M:M:?1 S:S:Y139 11.97354.57YesNo005
12M:M:?1 S:S:C210 32.62994.12YesNo109
13M:M:?1 S:S:W287 99.48635.17YesYes108
14M:M:?1 S:S:I294 15.51229.26YesNo105
15S:S:C210 S:S:W124 30.765920.89NoYes198
16S:S:F126 S:S:W124 19.679319.04YesYes078
17R:R:M112 R:R:V69 10.06794.56YesNo077
18R:R:F70 R:R:P113 19.63414.33YesNo078
19L:L:?1 R:R:W287 35.13085.91YesYes208
20R:R:N322 R:R:W287 11.66116.78YesYes298
21R:R:N322 R:R:N326 10.12869.54YesYes099
22L:L:?1 R:R:Y139 44.11746.09YesNo005
23R:R:V189 R:R:Y139 43.5695.05YesNo055
24R:R:F143 R:R:V189 42.01749.18NoYes065
25R:R:F143 R:R:F147 41.3444.29NoNo066
26R:R:F147 R:R:I182 41.01777.54NoNo067
27R:R:I182 R:R:N100 40.36344.25NoYes479
28R:R:N100 R:R:N179 39.365520.43YesNo097
29R:R:I96 R:R:N179 25.05424.25YesNo057
30R:R:I96 R:R:K91 29.03041.45YesNo057
31R:R:I84 R:R:K91 29.08941.45NoNo077
32R:R:F337 R:R:I84 29.2233.77YesNo087
33R:R:F337 R:R:F341 48.9379.65YesYes086
34R:R:F341 R:R:L79 49.61386.09YesNo066
35R:R:F344 R:R:L79 49.67814.87NoNo046
36R:R:N100 R:R:W183 13.604910.17YesYes499
37R:R:N179 R:R:Y97 22.07784.65NoYes077
38R:R:M152 R:R:Y97 16.96845.99NoYes087
39R:R:M152 R:R:V276 16.01216.09NoNo088
40R:R:R156 R:R:V276 19.15176.54YesNo098
41R:R:I272 R:R:R156 19.26978.77NoYes679
42L:L:?1 R:R:C210 14.69134.12YesNo209
43R:R:C210 R:R:W124 12.90223.51NoYes298
44R:R:F126 R:R:W124 14.040515.03YesYes078
45R:R:F114 R:R:F126 18.462716.08NoYes057
46L:L:?1 R:R:I316 10.46534.63YesYes205
47R:R:I316 R:R:Y312 14.587213.3YesNo054
48S:S:I316 S:S:Q115 11.64895.49NoNo057
49S:S:I316 S:S:Y312 10.697910.88NoNo054
50R:R:F126 R:R:P125 17.936813YesNo071
51R:R:M121 R:R:P125 17.02396.71NoNo041
52R:R:M121 R:R:S123 16.10753.07NoNo044
53L:L:?1 R:R:M142 12.185211.01YesNo207
54R:R:H291 R:R:M142 11.32445.25NoNo287
55R:R:H291 R:R:W287 12.79094.23NoYes288
56R:R:V276 R:R:Y246 24.18473.79NoYes088
57R:R:M249 R:R:Y246 17.90383.59NoYes088
58R:R:M249 R:R:Y157 16.99273.59NoYes087
59R:R:R252 R:R:Y157 10.517418.52NoYes057
60L:L:?1 R:R:I294 18.879210.19YesNo005
61R:R:I294 R:R:K227 18.8677.27NoYes054
62R:R:D223 R:R:K227 13.738516.59NoYes044
63R:R:D223 R:R:Y219 12.702412.64NoNo041
64R:R:F214 R:R:Y219 10.619812.38YesNo061
65R:R:F235 R:R:H291 22.282615.84YesNo088
66R:R:D334 R:R:F337 25.904611.94YesYes088
67R:R:D334 R:R:R271 21.843510.72YesYes087
68R:R:I272 R:R:R271 19.93446.26NoYes077
69R:R:C345 R:R:F344 50.45562.79NoNo054
70R:R:C345 R:R:F346 50.66732.79NoYes054
71S:S:N322 S:S:W287 95.72364.52YesYes198
72S:S:N322 S:S:N326 95.06766.81YesYes199
73S:S:N326 S:S:Y330 96.438.14YesYes099
74S:S:F337 S:S:Y330 64.8645.16YesYes089
75S:S:F337 S:S:F341 55.95386.43YesYes086
76R:R:F346 S:S:F341 53.17694.29YesYes046
77S:S:M112 S:S:V69 15.24674.56YesYes077
78S:S:S324 S:S:V69 10.75176.46NoYes077
79S:S:I98 S:S:Y330 75.86219.67NoYes089
80S:S:I98 S:S:M152 75.17144.37NoNo088
81S:S:M152 S:S:Y97 44.56177.18NoYes087
82S:S:M152 S:S:V276 32.68027.61NoNo088
83S:S:N179 S:S:Y97 27.32784.65NoYes077
84S:S:M151 S:S:Y97 13.84615.99NoYes367
85S:S:N100 S:S:N179 19.158620.43NoNo097
86S:S:N100 S:S:W183 14.41549.04NoNo099
87S:S:W183 S:S:Y140 10.70836.75NoYes095
88S:S:L212 S:S:Y139 10.99465.86NoNo045
89S:S:V276 S:S:Y246 23.55477.57NoYes088
90S:S:M151 S:S:V154 12.98184.56NoNo066
91S:S:M249 S:S:Y246 17.334610.78NoYes088
92S:S:M249 S:S:V160 16.43564.56NoNo088
93S:S:C245 S:S:V154 12.07413.42NoNo076
94S:S:C245 S:S:Y157 11.18734.03NoYes077
95S:S:F214 S:S:L212 10.01237.31YesNo064
96S:S:I294 S:S:K227 14.59417.27NoYes054
97S:S:H291 S:S:W287 11.09014.23NoYes088
98S:S:F235 S:S:H291 10.099113.58YesNo088
99R:R:F114 R:R:P113 18.76465.78NoNo058
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
M:M:?1 S:S:T111 6.7 1 Yes Yes 0 7 0 1
M:M:?1 S:S:Q115 7.78 1 Yes No 0 7 0 1
M:M:?1 S:S:D138 37 1 Yes No 0 6 0 1
M:M:?1 S:S:Y139 4.57 1 Yes No 0 5 0 1
M:M:?1 S:S:M142 12.85 1 Yes No 0 7 0 1
M:M:?1 S:S:C210 4.12 1 Yes No 0 9 0 1
M:M:?1 S:S:V230 6.77 1 Yes No 0 5 0 1
M:M:?1 S:S:W287 5.17 1 Yes Yes 0 8 0 1
M:M:?1 S:S:I290 4.63 1 Yes No 0 6 0 1
M:M:?1 S:S:I294 9.26 1 Yes No 0 5 0 1
M:M:?1 S:S:Y320 15.98 1 Yes No 0 6 0 1
S:S:I137 S:S:T111 4.56 0 No Yes 5 7 2 1
S:S:T111 S:S:Y320 4.99 1 Yes No 7 6 1 1
S:S:M112 S:S:Y320 17.96 0 Yes No 7 6 2 1
S:S:I316 S:S:Q115 5.49 0 No No 5 7 2 1
S:S:C131 S:S:W124 7.84 1 No Yes 9 8 2 2
S:S:C210 S:S:W124 20.89 1 No Yes 9 8 1 2
S:S:C131 S:S:C210 7.28 1 No No 9 9 2 1
S:S:L212 S:S:Y139 5.86 0 No No 4 5 2 1
S:S:F143 S:S:M142 4.98 0 Yes No 6 7 2 1
S:S:M142 S:S:W287 5.82 1 No Yes 7 8 1 1
S:S:F143 S:S:V230 6.55 0 Yes No 6 5 2 1
S:S:I294 S:S:K227 7.27 1 No Yes 5 4 1 2
S:S:F283 S:S:W287 21.05 1 Yes Yes 9 8 2 1
S:S:F283 S:S:N322 9.67 1 Yes Yes 9 9 2 2
S:S:H291 S:S:W287 4.23 0 No Yes 8 8 2 1
S:S:N322 S:S:W287 4.52 1 Yes Yes 9 8 2 1
S:S:I290 S:S:I294 4.42 1 No No 6 5 1 1
M:M:?1 S:S:L135 3.59 1 Yes No 0 4 0 1
S:S:G319 S:S:W287 2.81 0 No Yes 7 8 2 1
S:S:T110 S:S:T111 1.57 0 No Yes 4 7 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:T111 5.74 2 Yes Yes 0 7 0 1
L:L:?1 R:R:Q115 9.5 2 Yes No 0 7 0 1
L:L:?1 R:R:D138 33.47 2 Yes No 0 6 0 1
L:L:?1 R:R:Y139 6.09 2 Yes No 0 5 0 1
L:L:?1 R:R:M142 11.01 2 Yes No 0 7 0 1
L:L:?1 R:R:C210 4.12 2 Yes No 0 9 0 1
L:L:?1 R:R:V230 8.7 2 Yes No 0 5 0 1
L:L:?1 R:R:W287 5.91 2 Yes Yes 0 8 0 1
L:L:?1 R:R:I294 10.19 2 Yes No 0 5 0 1
L:L:?1 R:R:I316 4.63 2 Yes Yes 0 5 0 1
L:L:?1 R:R:Y320 13.7 2 Yes Yes 0 6 0 1
R:R:I137 R:R:T111 4.56 0 No Yes 5 7 2 1
R:R:T111 R:R:Y320 4.99 2 Yes Yes 7 6 1 1
R:R:M112 R:R:Y320 17.96 0 Yes Yes 7 6 2 1
R:R:I316 R:R:Q115 5.49 2 Yes No 5 7 1 1
R:R:Q115 R:R:Y320 5.64 2 No Yes 7 6 1 1
R:R:C131 R:R:W124 5.22 2 No Yes 9 8 2 2
R:R:C210 R:R:W124 23.51 2 No Yes 9 8 1 2
R:R:C131 R:R:C210 7.28 2 No No 9 9 2 1
R:R:V189 R:R:Y139 5.05 0 Yes No 5 5 2 1
R:R:N141 R:R:W287 4.52 0 No Yes 8 8 2 1
R:R:M142 R:R:W287 6.98 2 No Yes 7 8 1 1
R:R:H291 R:R:M142 5.25 2 No No 8 7 2 1
R:R:I294 R:R:K227 7.27 0 No Yes 5 4 1 2
R:R:F283 R:R:W287 22.05 2 Yes Yes 9 8 2 1
R:R:F283 R:R:N322 7.25 2 Yes Yes 9 9 2 2
R:R:I290 R:R:W287 4.7 0 No Yes 6 8 2 1
R:R:H291 R:R:W287 4.23 2 No Yes 8 8 2 1
R:R:G319 R:R:W287 4.22 0 No Yes 7 8 2 1
R:R:N322 R:R:W287 6.78 2 Yes Yes 9 8 2 1
R:R:I290 R:R:I294 4.42 0 No No 6 5 2 1
R:R:I290 R:R:I316 4.42 0 No Yes 6 5 2 1
R:R:I316 R:R:Y312 13.3 2 Yes No 5 4 1 2
L:L:?1 R:R:L135 2.7 2 Yes No 0 4 0 1
R:R:T110 R:R:T111 1.57 0 No Yes 4 7 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 4DJH_poly
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.96
Number of Linked Nodes 543
Number of Links 573
Number of Hubs 65
Number of Links mediated by Hubs 274
Number of Communities 9
Number of Nodes involved in Communities 57
Number of Links involved in Communities 72
Path Summary
Number Of Nodes in MetaPath 100
Number Of Links MetaPath 99
Number of Shortest Paths 162744
Length Of Smallest Path 3
Average Path Length 16.5137
Length of Longest Path 38
Minimum Path Strength 1.275
Average Path Strength 7.34899
Maximum Path Strength 26.49
Minimum Path Correlation 0.7
Average Path Correlation 0.96214
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.84615
Average % Of Corr. Nodes 57.3879
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.4791
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • neuropeptide binding   • peptide binding   • peptide receptor activity   • molecular transducer activity   • G protein-coupled opioid receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • G protein-coupled peptide receptor activity   • dynorphin receptor activity   • protein binding   • receptor serine/threonine kinase binding   • signaling receptor binding   • hydrolase activity, acting on glycosyl bonds   • peptidoglycan muralytic activity   • hydrolase activity, hydrolyzing O-glycosyl compounds   • lysozyme activity   • hydrolase activity   • catalytic activity   • ovulation cycle   • rhythmic process   • estrous cycle   • reproductive process   • multicellular organismal reproductive process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • cell communication   • G protein-coupled opioid receptor signaling pathway   • G protein-coupled receptor signaling pathway
Gene OntologyBiological Process• ovulation cycle   • rhythmic process   • estrous cycle   • reproductive process   • multicellular organismal reproductive process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • cell communication   • G protein-coupled opioid receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • multicellular organismal process   • system process   • sensory perception   • nervous system process   • phospholipase C-activating G protein-coupled receptor signaling pathway   • trans-synaptic signaling   • synaptic signaling   • anterograde trans-synaptic signaling   • cell-cell signaling   • chemical synaptic transmission   • behavior   • learning   • learning or memory   • cognition   • conditioned place preference   • associative learning   • biological process involved in interspecies interaction between organisms   • response to other organism   • defense response   • response to external stimulus   • response to biotic stimulus   • defense response to virus   • defense response to other organism   • response to stress   • response to external biotic stimulus   • response to virus   • response to acrylamide   • response to chemical   • response to oxygen-containing compound   • response to nitrogen compound   • neuropeptide signaling pathway   • locomotory behavior   • adult behavior   • behavioral response to cocaine   • response to cocaine   • response to alkaloid   • response to hormone   • response to endogenous stimulus   • response to estrogen   • immune response   • immune system process   • homeostatic process   • cellular response to glucose stimulus   • intracellular glucose homeostasis   • cellular response to oxygen-containing compound   • response to hexose   • cellular response to carbohydrate stimulus   • cellular response to chemical stimulus   • cellular homeostasis   • response to monosaccharide   • response to carbohydrate   • chemical homeostasis   • response to glucose   • glucose homeostasis   • carbohydrate homeostasis   • cellular response to hexose stimulus   • intracellular chemical homeostasis   • cellular response to monosaccharide stimulus   • maternal behavior   • parental behavior   • reproductive behavior   • regulation of localization   • negative regulation of luteinizing hormone secretion   • regulation of system process   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • regulation of luteinizing hormone secretion   • luteinizing hormone secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • regulation of biological quality   • regulation of hormone levels   • establishment of localization   • regulation of secretion   • endocrine hormone secretion   • negative regulation of gonadotropin secretion   • negative regulation of multicellular organismal process   • regulation of endocrine process   • regulation of hormone secretion   • gonadotropin secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • secretion by cell   • regulation of secretion by cell   • signal release   • negative regulation of cellular process   • regulation of multicellular organismal process   • regulation of signaling   • secretion   • regulation of transport   • regulation of gonadotropin secretion   • export from cell   • endocrine process   • hormone transport   • regulation of cell communication   • eating behavior   • feeding behavior   • sensory perception of temperature stimulus   • response to lipid   • cellular response to lipopolysaccharide   • cellular response to molecule of bacterial origin   • response to lipopolysaccharide   • cellular response to biotic stimulus   • response to bacterium   • cellular response to lipid   • response to molecule of bacterial origin   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-inhibiting opioid receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • monoamine transport   • nitrogen compound transport   • regulation of catecholamine secretion   • positive regulation of biological process   • organic hydroxy compound transport   • positive regulation of secretion by cell   • dopamine transport   • positive regulation of amine transport   • catecholamine transport   • positive regulation of secretion   • positive regulation of cellular process   • positive regulation of catecholamine secretion   • dopamine secretion   • positive regulation of dopamine secretion   • catecholamine secretion   • amine transport   • positive regulation of transport   • regulation of amine transport   • regulation of dopamine secretion   • regulation of body fluid levels   • secretion by tissue   • digestive system process   • regulation of digestive system process   • body fluid secretion   • digestion   • saliva secretion   • regulation of saliva secretion   • response to alcohol   • response to ethanol   • response to peptide hormone   • response to insulin   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • p38MAPK cascade   • intracellular signal transduction   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • intracellular signaling cassette   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • positive regulation of p38MAPK cascade   • regulation of response to stimulus   • regulation of p38MAPK cascade   • MAPK cascade   • positive regulation of signaling   • regulation of eating behavior   • positive regulation of feeding behavior   • positive regulation of eating behavior   • regulation of behavior   • positive regulation of behavior   • positive regulation of multicellular organismal process   • regulation of feeding behavior   • sensory perception of pain   • response to nicotine   • positive regulation of cation transmembrane transport   • regulation of potassium ion transport   • monoatomic ion transmembrane transport   • potassium ion transmembrane transport   • regulation of monoatomic ion transmembrane transport   • metal ion transport   • monoatomic cation transmembrane transport   • positive regulation of monoatomic ion transport   • positive regulation of transmembrane transport   • monoatomic ion transport   • positive regulation of monoatomic ion transmembrane transport   • monoatomic cation transport   • regulation of metal ion transport   • regulation of monoatomic ion transport   • inorganic ion transmembrane transport   • regulation of potassium ion transmembrane transport   • inorganic cation transmembrane transport   • transmembrane transport   • positive regulation of potassium ion transport   • regulation of transmembrane transport   • positive regulation of potassium ion transmembrane transport   • regulation of monoatomic cation transmembrane transport   • potassium ion transport   • defense response to bacterium   • carbohydrate derivative catabolic process   • catabolic process   • peptidoglycan catabolic process   • glycosaminoglycan metabolic process   • carbohydrate derivative metabolic process   • aminoglycan catabolic process   • macromolecule catabolic process   • glycosaminoglycan catabolic process   • aminoglycan metabolic process   • peptidoglycan metabolic process   • metabolic process   • macromolecule metabolic process   • symbiont-mediated cytolysis of host cell   • viral life cycle   • disruption of cell in another organism   • cytolysis   • biological process involved in interaction with host   • biological process involved in symbiotic interaction   • viral release from host cell by cytolysis   • exit from host cell   • viral process   • cytolysis in another organism   • viral release from host cell   • disruption of anatomical structure in another organism   • symbiont-mediated killing of host cell   • killing of cells of another organism   • cell killing   • cell wall organization or biogenesis   • cell wall macromolecule catabolic process   • cell wall macromolecule metabolic process   • cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • sarcolemma   • T-tubule   • somatodendritic compartment   • cell body
Gene OntologyCellular Component• cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • sarcolemma   • T-tubule   • somatodendritic compartment   • cell body   • perikaryon   • neuronal cell body   • intracellular anatomical structure   • cytoplasm   • cytosol   • presynapse   • presynaptic membrane   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • membrane-bounded organelle   • intracellular membrane-bounded organelle   • endomembrane system   • sarcoplasm   • intracellular organelle   • organelle   • endoplasmic reticulum   • sarcoplasmic reticulum   • intracellular vesicle   • transport vesicle membrane   • bounding membrane of organelle   • cytoplasmic vesicle   • vesicle membrane   • synaptic vesicle   • synaptic vesicle membrane   • vesicle   • transport vesicle   • exocytic vesicle membrane   • cytoplasmic vesicle membrane   • secretory vesicle   • organelle membrane   • exocytic vesicle   • mitochondrion   • nucleus   • membrane-enclosed lumen   • intracellular organelle lumen   • nucleoplasm   • organelle lumen   • nuclear lumen   • axon   • axon terminus   • distal axon   • neuron projection terminus   • host cellular component   • host intracellular part   • host cell cytoplasm   • host cell part   • host intracellular region
SCOP2Domain Identifier• G protein-coupled receptor-like
SCOP2Family Identifier• G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeJDC
PDB ResiduesL:L:?1 M:M:?1
Environment DetailsOpen EMBL-EBI Page
CodeJDC
Name(3R)-7-hydroxy-N-{(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
Synonyms
Identifier
FormulaC28 H39 N3 O3
Molecular Weight465.628
SMILES
PubChem9956146
Formal Charge0
Total Atoms73
Total Chiral Atoms4
Total Bonds76
Total Aromatic Bonds12

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP41145
Sequence
>4DJH_poly_Chain_R
SPAIPVIIT AVYSVVFVV GLVGNSLVM FVIIRYTKM KTATNIYIF 
NLALADALV TTTMPFQST VYLMNSWPF GDVLCKIVL SIDYYNMFT 
SIFTLTMMS VDRYIAVCH PVKALDFRT PLKAKIINI CIWLLSSSV 
GISAIVLGG TKVREDVDV IECSLQFPD DDYSWWDLF MKICVFIFA 
FVIPVLIII VCYTLMILR LKSVRLLSG REKDRNLRR ITRLVLVVV 
AVFVVCWTP IHIFILVEA LGSAALSSY YFCIALGYT NSSLNPILY 
AFLDENFKR CFRDFCFP


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  






You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 4DJH_poly.zip



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