psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P56	R:R:S55	5.34	No	No	0	2	1
2	R:R:I58	R:R:P59	6.77	No	No	0	4	4
3	R:R:V60	S:S:F114	10.49	No	No	0	5	5
4	R:R:M112	R:R:Y66	5.99	Yes	No	0	7	6
5	R:R:S116	R:R:Y66	8.9	No	No	0	6	6
6	R:R:S67	S:S:S67	6.52	No	No	0	4	4
7	R:R:S67	S:S:F70	3.96	No	Yes	0	4	7
8	R:R:M112	R:R:V69	4.56	Yes	No	0	7	7
9	R:R:S324	R:R:V69	8.08	No	No	0	7	7
10	R:R:F70	R:R:T109	3.89	Yes	No	1	7	6
11	R:R:F70	R:R:M112	4.98	Yes	Yes	1	7	7
12	R:R:F70	R:R:P113	4.33	Yes	No	0	7	8
13	R:R:F70	S:S:S67	3.96	Yes	No	0	7	4
14	R:R:V71	S:S:V71	11.22	No	No	0	5	5
15	R:R:G76	R:R:P327	4.06	No	No	0	7	9
16	R:R:A102	R:R:N77	4.69	No	No	0	8	9
17	R:R:D105	R:R:N77	5.39	No	No	0	9	9
18	R:R:N77	R:R:P327	11.4	No	No	0	9	9
19	R:R:F341	R:R:L79	6.09	Yes	No	0	6	6
20	R:R:F344	R:R:L79	4.87	No	No	0	4	6
21	R:R:V80	R:R:Y330	3.79	No	Yes	0	9	9
22	R:R:F99	R:R:M81	4.98	No	Yes	0	5	7
23	R:R:L103	R:R:M81	4.24	No	Yes	0	6	7
24	R:R:F82	R:R:R86	4.28	No	No	0	4	5
25	R:R:F344	R:R:F82	7.5	No	No	0	4	4
26	R:R:C340	R:R:V83	5.12	No	No	0	6	8
27	R:R:F99	R:R:I85	7.54	No	No	0	5	3
28	R:R:R86	R:R:Y87	4.12	No	No	0	5	5
29	R:R:C340	R:R:Y87	4.03	No	No	0	6	5
30	R:R:M90	R:R:N95	5.61	No	No	5	7	7
31	R:R:F337	R:R:M90	7.46	Yes	No	5	8	7
32	R:R:N95	R:R:T92	5.85	No	No	0	7	7
33	R:R:A93	R:R:D155	4.63	No	No	0	6	8
34	R:R:R156	R:R:T94	6.47	Yes	No	6	9	8
35	R:R:I272	R:R:T94	4.56	No	No	6	7	8
36	R:R:F337	R:R:N95	7.25	Yes	No	5	8	7
37	R:R:A175	R:R:I96	4.87	No	Yes	0	7	5
38	R:R:I96	R:R:N179	4.25	Yes	No	0	5	7
39	R:R:M152	R:R:Y97	5.99	No	Yes	0	8	7
40	R:R:D155	R:R:Y97	8.05	No	Yes	0	8	7
41	R:R:A175	R:R:Y97	6.67	No	Yes	0	7	7
42	R:R:I178	R:R:Y97	7.25	No	Yes	0	6	7
43	R:R:N179	R:R:Y97	4.65	No	Yes	0	7	7
44	R:R:I98	R:R:Y330	12.09	No	Yes	0	8	9
45	R:R:N100	R:R:T144	4.39	Yes	Yes	4	9	7
46	R:R:N100	R:R:T148	8.77	Yes	No	4	9	7
47	R:R:N100	R:R:N179	20.43	Yes	No	0	9	7
48	R:R:I182	R:R:N100	4.25	No	Yes	4	7	9
49	R:R:N100	R:R:W183	10.17	Yes	Yes	4	9	9
50	R:R:L101	R:R:L149	6.92	No	No	0	9	8
51	R:R:L101	R:R:Y330	4.69	No	Yes	0	9	9
52	R:R:L103	R:R:W183	4.56	No	Yes	0	6	9
53	R:R:D105	R:R:S323	8.83	No	No	0	9	8
54	R:R:D105	R:R:N326	6.73	No	Yes	0	9	9
55	R:R:N141	R:R:V108	16.26	No	No	0	8	7
56	R:R:M112	R:R:T109	6.02	Yes	No	1	7	6
57	R:R:I137	R:R:T111	4.56	No	Yes	0	5	7
58	R:R:T111	R:R:Y320	4.99	Yes	Yes	1	7	6
59	L:L:?1	R:R:T111	5.74	Yes	Yes	1	0	7
60	R:R:M112	R:R:Y320	17.96	Yes	Yes	1	7	6
61	R:R:F114	R:R:P113	5.78	No	No	0	5	8
62	R:R:F114	R:R:F126	16.08	No	Yes	0	5	7
63	R:R:F114	S:S:V60	10.49	No	No	0	5	5
64	R:R:I316	R:R:Q115	5.49	Yes	No	1	5	7
65	R:R:Q115	R:R:Y320	5.64	No	Yes	1	7	6
66	L:L:?1	R:R:Q115	9.5	Yes	No	1	0	7
67	R:R:F126	R:R:T117	3.89	Yes	No	0	7	4
68	R:R:Y119	R:R:Y313	10.92	No	No	0	4	4
69	R:R:L120	S:S:L120	6.92	No	No	0	4	4
70	R:R:M121	R:R:P125	6.71	No	No	0	4	1
71	R:R:N122	R:R:V207	4.43	No	No	0	5	3
72	R:R:F126	R:R:W124	15.03	Yes	Yes	0	7	8
73	R:R:C131	R:R:W124	5.22	No	Yes	1	9	8
74	R:R:V134	R:R:W124	7.36	No	Yes	0	6	8
75	R:R:C210	R:R:W124	23.51	No	Yes	1	9	8
76	R:R:F126	R:R:P125	13	Yes	No	0	7	1
77	R:R:F126	R:R:L130	7.31	Yes	No	0	7	5
78	R:R:D128	R:R:G198	5.03	No	No	0	2	4
79	R:R:D128	R:R:T199	5.78	No	No	0	2	4
80	R:R:C131	R:R:C210	7.28	No	No	1	9	9
81	L:L:?1	R:R:V134	3.87	Yes	No	0	0	6
82	R:R:I194	R:R:S136	6.19	No	No	0	4	5
83	L:L:?1	R:R:D138	33.47	Yes	No	0	0	6
84	R:R:V189	R:R:Y139	5.05	Yes	No	0	5	5
85	L:L:?1	R:R:Y139	6.09	Yes	No	0	0	5
86	R:R:W183	R:R:Y140	8.68	Yes	Yes	0	9	5
87	R:R:S187	R:R:Y140	7.63	No	Yes	0	4	5
88	R:R:G190	R:R:Y140	10.14	No	Yes	0	6	5
89	R:R:N141	R:R:W287	4.52	No	Yes	0	8	8
90	R:R:M142	R:R:W287	6.98	No	Yes	1	7	8
91	R:R:H291	R:R:M142	5.25	No	No	1	8	7
92	L:L:?1	R:R:M142	11.01	Yes	No	1	0	7
93	R:R:F143	R:R:F147	4.29	No	No	0	6	6
94	R:R:F143	R:R:V189	9.18	No	Yes	0	6	5
95	R:R:A234	R:R:F143	8.32	No	No	0	6	6
96	R:R:T144	R:R:W183	15.77	Yes	Yes	4	7	9
97	R:R:S186	R:R:T144	4.8	No	Yes	0	8	7
98	R:R:F283	R:R:S145	3.96	Yes	No	0	9	9
99	R:R:I146	R:R:P238	6.77	No	No	0	7	9
100	R:R:F283	R:R:I146	7.54	Yes	No	0	9	7
101	R:R:F147	R:R:I182	7.54	No	No	0	6	7
102	R:R:I182	R:R:T148	4.56	No	No	4	7	7
103	R:R:F283	R:R:L149	6.09	Yes	No	0	9	8
104	R:R:I242	R:R:T150	7.6	No	No	0	8	7
105	R:R:I178	R:R:M151	5.83	No	No	0	6	6
106	R:R:M152	R:R:V276	6.09	No	No	0	8	8
107	R:R:I242	R:R:S153	7.74	No	No	0	8	9
108	R:R:S153	R:R:Y246	10.17	No	Yes	0	9	8
109	R:R:A159	R:R:R156	5.53	No	Yes	0	8	9
110	R:R:I272	R:R:R156	8.77	No	Yes	6	7	9
111	R:R:R156	R:R:T273	10.35	Yes	No	0	9	6
112	R:R:R156	R:R:V276	6.54	Yes	No	0	9	8
113	R:R:C245	R:R:Y157	4.03	No	Yes	0	7	7
114	R:R:L248	R:R:Y157	7.03	No	Yes	0	4	7
115	R:R:R252	R:R:Y157	18.52	No	Yes	0	5	7
116	R:R:R252	R:R:V160	6.54	No	No	0	5	8
117	R:R:L253	R:R:V160	4.47	No	No	0	8	8
118	R:R:C161	R:R:R252	8.36	No	No	0	7	5
119	R:R:D168	R:R:K165	5.53	No	No	7	4	4
120	R:R:K165	R:R:R170	11.14	No	No	7	4	6
121	R:R:D168	R:R:R170	7.15	No	No	7	4	6
122	R:R:D168	R:R:T171	4.34	No	No	0	4	7
123	R:R:P172	R:R:T171	5.25	No	No	0	2	7
124	R:R:K176	R:R:L173	4.23	No	No	0	4	4
125	R:R:I180	R:R:L184	4.28	No	No	0	4	4
126	R:R:F214	R:R:L196	4.87	Yes	No	0	6	4
127	R:R:G198	R:R:Q213	6.58	No	No	0	4	4
128	R:R:I208	R:R:T199	4.56	No	No	0	4	4
129	R:R:E209	R:R:K200	12.15	No	No	0	3	2
130	R:R:R202	R:R:V205	3.92	No	No	0	2	1
131	R:R:E209	R:R:R202	16.28	No	No	0	3	2
132	R:R:V205	R:R:V207	6.41	No	No	0	1	3
133	L:L:?1	R:R:C210	4.12	Yes	No	1	0	9
134	R:R:S211	R:R:Y219	3.82	No	No	0	4	1
135	R:R:F214	R:R:Y219	12.38	Yes	No	0	6	1
136	R:R:F214	R:R:W222	7.02	Yes	Yes	0	6	7
137	R:R:F214	R:R:M226	6.22	Yes	No	0	6	5
138	R:R:P215	R:R:W222	5.4	No	Yes	0	5	7
139	R:R:D216	R:R:D217	6.65	No	No	0	2	1
140	R:R:D223	R:R:Y219	12.64	No	No	0	4	1
141	R:R:W221	R:R:W222	17.81	No	Yes	8	1	7
142	R:R:F225	R:R:W221	15.03	No	No	8	4	1
143	R:R:F225	R:R:W222	4.01	No	Yes	8	4	7
144	R:R:D223	R:R:K227	16.59	No	Yes	0	4	4
145	R:R:I228	R:R:L224	4.28	No	No	0	5	3
146	R:R:C229	R:R:F225	4.19	No	No	0	3	4
147	R:R:I294	R:R:K227	7.27	No	Yes	0	5	4
148	R:R:E297	R:R:K227	4.05	No	Yes	0	5	4
149	L:L:?1	R:R:V230	8.7	Yes	No	0	0	5
150	R:R:F231	R:R:V236	5.24	No	No	0	5	4
151	R:R:F231	R:R:L295	15.83	No	No	0	5	5
152	R:R:F233	R:R:I232	6.28	No	No	0	4	5
153	R:R:F235	R:R:V239	5.24	Yes	No	0	8	6
154	R:R:F235	R:R:T288	6.49	Yes	No	0	8	5
155	R:R:F235	R:R:H291	15.84	Yes	No	0	8	8
156	R:R:I237	R:R:P238	5.08	No	No	0	5	9
157	R:R:V276	R:R:Y246	3.79	No	Yes	0	8	8
158	R:R:L277	R:R:Y246	17.58	No	Yes	0	4	8
159	R:R:K254	R:R:R257	7.43	No	No	0	4	4
160	R:R:R257	R:R:S255	7.91	No	No	0	4	4
161	R:R:L258	R:R:R257	18.22	No	No	0	5	4
162	R:R:R263	R:R:S260	3.95	No	No	0	3	4
163	R:R:D266	R:R:K265	9.68	No	No	0	3	4
164	R:R:D266	R:R:L269	5.43	No	No	0	3	6
165	R:R:E335	R:R:N268	5.26	Yes	No	0	4	5
166	R:R:R271	R:R:R274	18.13	No	No	0	7	6
167	R:R:L275	R:R:L333	4.15	No	No	0	8	7
168	R:R:D334	R:R:L275	4.07	No	No	0	8	8
169	R:R:L333	R:R:V278	4.47	No	No	0	7	5
170	R:R:F283	R:R:W287	22.05	Yes	Yes	1	9	8
171	R:R:F283	R:R:N322	7.25	Yes	Yes	1	9	9
172	R:R:C286	R:R:N322	7.87	No	Yes	0	8	9
173	R:R:I290	R:R:W287	4.7	No	Yes	0	6	8
174	R:R:H291	R:R:W287	4.23	No	Yes	1	8	8
175	R:R:G319	R:R:W287	4.22	No	Yes	0	7	8
176	R:R:N322	R:R:W287	6.78	Yes	Yes	1	9	8
177	L:L:?1	R:R:W287	5.91	Yes	Yes	1	0	8
178	R:R:I290	R:R:I294	4.42	No	No	0	6	5
179	R:R:I290	R:R:I316	4.42	No	Yes	0	6	5
180	R:R:F293	R:R:Y312	7.22	No	No	0	5	4
181	R:R:C315	R:R:F293	4.19	No	No	0	7	5
182	L:L:?1	R:R:I294	10.19	Yes	No	0	0	5
183	R:R:L295	R:R:L299	4.15	No	No	0	5	4
184	R:R:L309	R:R:Y313	8.21	No	No	0	4	4
185	R:R:Y312	R:R:Y313	6.95	No	No	0	4	4
186	R:R:I316	R:R:Y312	13.3	Yes	No	0	5	4
187	R:R:F314	R:R:L318	6.09	No	No	0	5	8
188	L:L:?1	R:R:I316	4.63	Yes	Yes	1	0	5
189	L:L:?1	R:R:Y320	13.7	Yes	Yes	1	0	6
190	R:R:N322	R:R:N326	9.54	Yes	Yes	0	9	9
191	R:R:N326	R:R:Y330	8.14	Yes	Yes	0	9	9
192	R:R:D334	R:R:N336	8.08	No	No	0	8	6
193	R:R:D334	R:R:F337	11.94	No	Yes	0	8	8
194	R:R:E335	R:R:N336	6.57	Yes	No	0	4	6
195	R:R:E335	R:R:R339	8.14	Yes	No	0	4	5
196	R:R:F337	R:R:F341	9.65	Yes	Yes	0	8	6
197	R:R:K338	S:S:F346	4.96	No	No	0	8	4
198	R:R:F341	S:S:F346	6.43	Yes	No	0	6	4
199	R:R:D343	R:R:R342	7.15	No	No	0	3	5
200	R:R:R342	S:S:R342	13.86	No	Yes	0	5	5
201	R:R:F346	S:S:F341	4.29	Yes	Yes	0	4	6
202	R:R:F346	S:S:R342	6.41	Yes	Yes	0	4	5
203	S:S:I58	S:S:P59	6.77	No	No	0	4	4
204	S:S:M112	S:S:Y66	8.38	Yes	No	0	7	6
205	S:S:S116	S:S:Y66	7.63	No	No	0	6	6
206	S:S:M112	S:S:V69	4.56	Yes	Yes	0	7	7
207	S:S:S324	S:S:V69	6.46	No	Yes	0	7	7
208	S:S:F70	S:S:T109	3.89	Yes	No	0	7	6
209	S:S:F70	S:S:M112	6.22	Yes	Yes	0	7	7
210	S:S:F70	S:S:P113	4.33	Yes	No	0	7	8
211	S:S:G76	S:S:P327	4.06	No	No	0	7	9
212	S:S:A102	S:S:N77	4.69	No	No	0	8	9
213	S:S:D105	S:S:N77	8.08	Yes	No	0	9	9
214	S:S:N77	S:S:P327	11.4	No	No	0	9	9
215	S:S:F341	S:S:L79	7.31	Yes	No	0	6	6
216	S:S:F344	S:S:L79	9.74	No	No	0	4	6
217	S:S:V80	S:S:Y330	5.05	No	Yes	0	9	9
218	S:S:F99	S:S:M81	9.95	No	No	0	5	7
219	S:S:L103	S:S:M81	4.24	No	No	0	6	7
220	S:S:F344	S:S:F82	8.57	No	No	0	4	4
221	S:S:C340	S:S:V83	6.83	No	No	0	6	8
222	S:S:F99	S:S:I84	5.02	No	No	0	5	7
223	S:S:F337	S:S:I84	5.02	Yes	No	0	8	7
224	S:S:F99	S:S:I85	5.02	No	No	0	5	3
225	S:S:R86	S:S:Y87	4.12	No	No	0	5	5
226	S:S:C340	S:S:Y87	4.03	No	No	0	6	5
227	S:S:K89	S:S:T88	9.01	No	No	0	5	6
228	S:S:M90	S:S:N95	7.01	No	No	9	7	7
229	S:S:F337	S:S:M90	6.22	Yes	No	9	8	7
230	S:S:N95	S:S:T92	10.24	No	No	0	7	7
231	S:S:A93	S:S:D155	4.63	No	No	3	6	8
232	S:S:A93	S:S:R170	5.53	No	Yes	3	6	6
233	S:S:R156	S:S:T94	3.88	Yes	No	3	9	8
234	S:S:R170	S:S:T94	3.88	Yes	No	3	6	8
235	S:S:F337	S:S:N95	7.25	Yes	No	9	8	7
236	S:S:I96	S:S:N179	4.25	No	No	0	5	7
237	S:S:M151	S:S:Y97	5.99	No	Yes	3	6	7
238	S:S:M152	S:S:Y97	7.18	No	Yes	0	8	7
239	S:S:D155	S:S:Y97	9.2	No	Yes	3	8	7
240	S:S:A175	S:S:Y97	5.34	No	Yes	0	7	7
241	S:S:I178	S:S:Y97	6.04	No	Yes	3	6	7
242	S:S:N179	S:S:Y97	4.65	No	Yes	0	7	7
243	S:S:I98	S:S:M152	4.37	No	No	0	8	8
244	S:S:I98	S:S:Y330	9.67	No	Yes	0	8	9
245	S:S:N100	S:S:T148	8.77	No	No	0	9	7
246	S:S:N100	S:S:N179	20.43	No	No	0	9	7
247	S:S:N100	S:S:W183	9.04	No	No	0	9	9
248	S:S:D105	S:S:L101	8.14	Yes	No	2	9	9
249	S:S:L101	S:S:N326	5.49	No	Yes	2	9	9
250	S:S:D105	S:S:S323	8.83	Yes	No	0	9	8
251	S:S:D105	S:S:N326	6.73	Yes	Yes	2	9	9
252	S:S:N141	S:S:V108	16.26	No	No	0	8	7
253	S:S:I137	S:S:T111	4.56	No	Yes	0	5	7
254	S:S:T111	S:S:Y320	4.99	Yes	No	2	7	6
255	M:M:?1	S:S:T111	6.7	Yes	Yes	2	0	7
256	S:S:M112	S:S:Y320	17.96	Yes	No	0	7	6
257	S:S:F114	S:S:F126	13.93	No	Yes	0	5	7
258	S:S:I316	S:S:Q115	5.49	No	No	0	5	7
259	M:M:?1	S:S:Q115	7.78	Yes	No	0	0	7
260	S:S:F126	S:S:T117	7.78	Yes	No	0	7	4
261	S:S:Y119	S:S:Y313	16.88	No	No	0	4	4
262	S:S:M121	S:S:P125	6.71	No	No	0	4	1
263	S:S:F126	S:S:W124	19.04	Yes	Yes	0	7	8
264	S:S:C131	S:S:W124	7.84	No	Yes	2	9	8
265	S:S:V134	S:S:W124	7.36	No	Yes	0	6	8
266	S:S:T199	S:S:W124	4.85	No	Yes	0	4	8
267	S:S:C210	S:S:W124	20.89	No	Yes	2	9	8
268	S:S:F126	S:S:P125	14.45	Yes	No	0	7	1
269	S:S:F126	S:S:L130	6.09	Yes	No	0	7	5
270	S:S:D128	S:S:G198	5.03	No	No	0	2	4
271	S:S:D128	S:S:T199	14.45	No	No	0	2	4
272	S:S:C131	S:S:C210	7.28	No	No	2	9	9
273	M:M:?1	S:S:V134	3.87	Yes	No	0	0	6
274	S:S:S136	S:S:Y140	3.82	No	Yes	0	5	5
275	S:S:I194	S:S:S136	6.19	No	No	0	4	5
276	M:M:?1	S:S:D138	37	Yes	No	0	0	6
277	S:S:L212	S:S:Y139	5.86	No	No	0	4	5
278	M:M:?1	S:S:Y139	4.57	Yes	No	0	0	5
279	S:S:W183	S:S:Y140	6.75	No	Yes	0	9	5
280	S:S:S187	S:S:Y140	7.63	No	Yes	0	4	5
281	S:S:G190	S:S:Y140	8.69	No	Yes	0	6	5
282	S:S:F143	S:S:M142	4.98	Yes	Yes	0	6	7
283	S:S:M142	S:S:W287	5.82	Yes	Yes	2	7	8
284	S:S:H291	S:S:M142	3.94	No	Yes	2	8	7
285	M:M:?1	S:S:M142	12.85	Yes	Yes	2	0	7
286	S:S:F143	S:S:V189	10.49	Yes	No	0	6	5
287	S:S:F143	S:S:V230	6.55	Yes	No	0	6	5
288	S:S:A234	S:S:F143	6.93	No	Yes	0	6	6
289	S:S:I182	S:S:T144	4.56	No	Yes	0	7	7
290	S:S:T144	S:S:W183	18.19	Yes	No	0	7	9
291	S:S:S186	S:S:T144	4.8	No	Yes	0	8	7
292	S:S:F283	S:S:S145	5.28	Yes	No	0	9	9
293	S:S:I146	S:S:P238	6.77	No	No	0	7	9
294	S:S:F283	S:S:I146	6.28	Yes	No	0	9	7
295	S:S:F147	S:S:I182	7.54	No	No	0	6	7
296	S:S:F147	S:S:L185	6.09	No	No	0	6	4
297	S:S:I182	S:S:T148	4.56	No	No	0	7	7
298	S:S:F283	S:S:L149	8.53	Yes	No	0	9	8
299	S:S:I241	S:S:T150	4.56	No	No	0	6	7
300	S:S:I242	S:S:T150	7.6	No	No	0	8	7
301	S:S:M151	S:S:V154	4.56	No	No	0	6	6
302	S:S:I178	S:S:M151	5.83	No	No	3	6	6
303	S:S:M152	S:S:V276	7.61	No	No	0	8	8
304	S:S:I242	S:S:S153	9.29	No	No	0	8	9
305	S:S:S153	S:S:Y246	6.36	No	Yes	0	9	8
306	S:S:D155	S:S:R170	16.68	No	Yes	3	8	6
307	S:S:A159	S:S:R156	4.15	No	Yes	3	8	9
308	S:S:R156	S:S:R170	5.33	Yes	Yes	3	9	6
309	S:S:I272	S:S:R156	10.02	No	Yes	0	7	9
310	S:S:R156	S:S:T273	6.47	Yes	No	0	9	6
311	S:S:R156	S:S:V276	5.23	Yes	No	0	9	8
312	S:S:C161	S:S:Y157	8.06	Yes	Yes	10	7	7
313	S:S:H162	S:S:Y157	8.71	Yes	Yes	10	6	7
314	S:S:C245	S:S:Y157	4.03	No	Yes	0	7	7
315	S:S:L248	S:S:Y157	8.21	No	Yes	0	4	7
316	S:S:A159	S:S:R170	5.53	No	Yes	3	8	6
317	S:S:M249	S:S:V160	4.56	No	No	0	8	8
318	S:S:L253	S:S:V160	4.47	No	No	0	8	8
319	S:S:C161	S:S:H162	4.42	Yes	Yes	10	7	6
320	S:S:C161	S:S:R252	5.57	Yes	No	0	7	5
321	S:S:H162	S:S:K165	11.79	Yes	No	0	6	4
322	S:S:F169	S:S:K165	12.41	No	No	0	4	4
323	S:S:K174	S:S:T171	4.5	No	No	0	5	7
324	S:S:I191	S:S:S187	6.19	No	No	0	4	4
325	S:S:I208	S:S:T199	4.56	No	No	0	4	4
326	S:S:K200	S:S:Q213	4.07	No	No	0	2	4
327	S:S:R202	S:S:V205	5.23	Yes	No	11	2	1
328	S:S:R202	S:S:V207	3.92	Yes	Yes	11	2	3
329	S:S:E209	S:S:R202	12.79	No	Yes	0	3	2
330	S:S:D204	S:S:E203	6.5	No	No	0	2	1
331	S:S:V205	S:S:V207	8.02	No	Yes	11	1	3
332	M:M:?1	S:S:C210	4.12	Yes	No	2	0	9
333	S:S:F214	S:S:L212	7.31	Yes	No	0	6	4
334	S:S:F214	S:S:Y219	9.28	Yes	No	0	6	1
335	S:S:F214	S:S:W222	7.02	Yes	No	0	6	7
336	S:S:P215	S:S:W222	5.4	No	No	0	5	7
337	S:S:D216	S:S:D217	11.98	No	No	0	2	1
338	S:S:D218	S:S:W222	8.93	No	No	0	4	7
339	S:S:D223	S:S:K227	16.59	No	Yes	0	4	4
340	S:S:I228	S:S:L224	5.71	No	Yes	0	5	3
341	S:S:I294	S:S:K227	7.27	No	Yes	0	5	4
342	S:S:E297	S:S:K227	4.05	No	Yes	0	5	4
343	S:S:A298	S:S:K227	4.82	No	Yes	0	4	4
344	S:S:C229	S:S:F233	4.19	No	No	0	3	4
345	M:M:?1	S:S:V230	6.77	Yes	No	0	0	5
346	S:S:F231	S:S:F235	4.29	No	Yes	0	5	8
347	S:S:F231	S:S:V236	5.24	No	No	0	5	4
348	S:S:F231	S:S:L295	12.18	No	No	0	5	5
349	S:S:F235	S:S:V239	5.24	Yes	No	0	8	6
350	S:S:F235	S:S:T288	7.78	Yes	No	0	8	5
351	S:S:F235	S:S:H291	13.58	Yes	No	0	8	8
352	S:S:I237	S:S:P238	5.08	No	No	0	5	9
353	S:S:I242	S:S:V280	4.61	No	No	0	8	8
354	S:S:M249	S:S:Y246	10.78	No	Yes	0	8	8
355	S:S:V276	S:S:Y246	7.57	No	Yes	0	8	8
356	S:S:L277	S:S:Y246	17.58	No	Yes	0	4	8
357	S:S:R257	S:S:R263	14.93	No	No	0	4	3
358	S:S:N268	S:S:R257	6.03	No	No	0	5	4
359	S:S:L258	S:S:L259	4.15	No	No	0	5	3
360	S:S:R263	S:S:S260	5.27	No	No	0	3	4
361	S:S:E264	S:S:R267	9.3	No	No	0	3	4
362	S:S:D266	S:S:K265	4.15	No	No	0	3	4
363	S:S:R267	S:S:R274	5.33	No	No	12	4	6
364	S:S:L269	S:S:N268	10.98	No	No	0	6	5
365	S:S:L269	S:S:T273	5.9	No	No	0	6	6
366	S:S:E335	S:S:R271	15.12	No	No	0	4	7
367	S:S:L275	S:S:L333	6.92	No	No	0	8	7
368	S:S:L333	S:S:V278	4.47	No	No	0	7	5
369	S:S:F283	S:S:W287	21.05	Yes	Yes	2	9	8
370	S:S:F283	S:S:N322	9.67	Yes	Yes	2	9	9
371	S:S:C286	S:S:L318	4.76	No	No	0	8	8
372	S:S:C286	S:S:N322	9.45	No	Yes	0	8	9
373	S:S:H291	S:S:W287	4.23	No	Yes	2	8	8
374	S:S:N322	S:S:W287	4.52	Yes	Yes	2	9	8
375	M:M:?1	S:S:W287	5.17	Yes	Yes	2	0	8
376	S:S:I290	S:S:I294	4.42	No	No	2	6	5
377	M:M:?1	S:S:I290	4.63	Yes	No	2	0	6
378	S:S:E297	S:S:F293	4.66	No	Yes	0	5	5
379	S:S:F293	S:S:Y312	5.16	Yes	No	0	5	4
380	S:S:C315	S:S:F293	4.19	No	Yes	0	7	5
381	M:M:?1	S:S:I294	9.26	Yes	No	2	0	5
382	S:S:L309	S:S:Y313	4.69	No	No	0	4	4
383	S:S:Y312	S:S:Y313	8.94	No	No	0	4	4
384	S:S:I316	S:S:Y312	10.88	No	No	0	5	4
385	S:S:F314	S:S:L318	8.53	No	No	0	5	8
386	M:M:?1	S:S:Y320	15.98	Yes	No	2	0	6
387	S:S:N322	S:S:N326	6.81	Yes	Yes	2	9	9
388	S:S:N326	S:S:Y330	8.14	Yes	Yes	0	9	9
389	S:S:F337	S:S:Y330	5.16	Yes	Yes	0	8	9
390	S:S:D334	S:S:N336	6.73	No	No	0	8	6
391	S:S:D334	S:S:F337	11.94	No	Yes	0	8	8
392	S:S:F337	S:S:F341	6.43	Yes	Yes	0	8	6
393	S:S:D343	S:S:R342	10.72	No	Yes	0	3	5
394	S:S:C345	S:S:F346	8.38	No	No	0	5	4
395	R:R:F337	R:R:I84	3.77	Yes	No	0	8	7
396	R:R:F337	R:R:I98	3.77	Yes	No	0	8	8
397	R:R:C315	R:R:P289	3.77	No	No	0	7	9
398	S:S:C315	S:S:P289	3.77	No	No	0	7	9
399	R:R:T63	S:S:Y66	3.75	No	No	0	5	6
400	R:R:Y66	S:S:T63	3.75	No	No	0	6	5
401	S:S:F214	S:S:M226	3.73	Yes	No	0	6	5
402	S:S:S220	S:S:W221	3.71	No	No	0	2	1
403	R:R:V118	R:R:W124	3.68	No	Yes	0	5	8
404	S:S:V118	S:S:W124	3.68	No	Yes	0	5	8
405	R:R:F70	R:R:L74	3.65	Yes	No	0	7	6
406	R:R:F214	R:R:L212	3.65	Yes	No	0	6	4
407	S:S:F214	S:S:L196	3.65	Yes	No	0	6	4
408	R:R:G73	R:R:T109	3.64	No	No	0	8	6
409	S:S:G73	S:S:T109	3.64	No	No	0	8	6
410	S:S:L333	S:S:R274	3.64	No	No	0	7	6
411	R:R:M249	R:R:Y157	3.59	No	Yes	0	8	7
412	R:R:M249	R:R:Y246	3.59	No	Yes	0	8	8
413	M:M:?1	S:S:L135	3.59	Yes	No	0	0	4
414	S:S:P56	S:S:S55	3.56	No	No	0	2	1
415	S:S:L120	S:S:Y119	3.52	No	No	0	4	4
416	S:S:P172	S:S:T171	3.5	No	No	0	2	7
417	R:R:E335	R:R:R271	3.49	Yes	No	0	4	7
418	S:S:E203	S:S:R202	3.49	No	Yes	0	1	2
419	S:S:C245	S:S:V154	3.42	No	No	0	7	6
420	S:S:C161	S:S:V160	3.42	Yes	No	0	7	8
421	S:S:I96	S:S:P172	3.39	No	No	0	5	2
422	R:R:A104	R:R:T144	3.36	No	Yes	0	8	7
423	S:S:A104	S:S:T144	3.36	No	Yes	0	8	7
424	R:R:K338	S:S:P347	3.35	No	No	0	8	4
425	S:S:K91	S:S:P172	3.35	No	No	0	7	2
426	R:R:S310	R:R:S311	3.26	No	No	0	2	4
427	S:S:C340	S:S:M90	3.24	No	No	0	6	7
428	R:R:S324	R:R:V72	3.23	No	No	0	7	5
429	S:S:S324	S:S:V72	3.23	No	No	0	7	5
430	S:S:S323	S:S:V108	3.23	No	No	0	8	7
431	R:R:V71	R:R:V75	3.21	No	No	0	5	4
432	R:R:S324	R:R:T321	3.2	No	No	0	7	5
433	S:S:R267	S:S:R271	3.2	No	No	12	4	7
434	S:S:R271	S:S:R274	3.2	No	No	12	7	6
435	S:S:T321	S:S:V69	3.17	No	Yes	0	5	7
436	R:R:I208	R:R:S123	3.1	No	No	0	4	4
437	R:R:I191	R:R:S187	3.1	No	No	0	4	4
438	R:R:I328	R:R:V72	3.07	No	No	0	7	5
439	R:R:M121	R:R:S123	3.07	No	No	0	4	4
440	R:R:I243	R:R:V239	3.07	No	No	0	5	6
441	R:R:I242	R:R:V280	3.07	No	No	0	8	8
442	S:S:I328	S:S:V72	3.07	No	No	0	7	5
443	S:S:M121	S:S:S123	3.07	No	No	0	4	4
444	S:S:I243	S:S:V239	3.07	No	No	0	5	6
445	R:R:I241	R:R:T150	3.04	No	No	0	6	7
446	R:R:M151	R:R:V154	3.04	No	No	0	6	6
447	S:S:I292	S:S:T288	3.04	No	No	0	5	5
448	S:S:L74	S:S:S78	3	No	No	0	6	4
449	R:R:L130	R:R:V129	2.98	No	No	0	5	1
450	R:R:L329	R:R:V279	2.98	No	No	0	8	8
451	R:R:L329	R:R:V282	2.98	No	No	0	8	7
452	S:S:L240	S:S:V236	2.98	No	No	0	3	4
453	S:S:L248	S:S:V244	2.98	No	No	0	4	4
454	S:S:L329	S:S:V278	2.98	No	No	0	8	5
455	S:S:L329	S:S:V279	2.98	No	No	0	8	8
456	S:S:L329	S:S:V282	2.98	No	No	0	8	7
457	R:R:N326	R:R:V279	2.96	Yes	No	0	9	8
458	S:S:N122	S:S:V207	2.96	No	Yes	0	5	3
459	S:S:N326	S:S:V279	2.96	Yes	No	0	9	8
460	S:S:N322	S:S:V282	2.96	Yes	No	0	9	7
461	R:R:C161	R:R:H162	2.95	No	No	0	7	6
462	R:R:L325	R:R:T321	2.95	No	No	0	6	5
463	S:S:L74	S:S:T109	2.95	No	No	0	6	6
464	S:S:L248	S:S:T247	2.95	No	No	0	4	4
465	S:S:L325	S:S:T321	2.95	No	No	0	6	5
466	R:R:I58	R:R:I62	2.94	No	No	0	4	5
467	R:R:I133	R:R:I137	2.94	No	No	0	5	5
468	R:R:I232	R:R:I237	2.94	No	No	0	5	5
469	S:S:I58	S:S:I62	2.94	No	No	0	4	5
470	S:S:I232	S:S:I237	2.94	No	No	0	5	5
471	R:R:I96	R:R:K176	2.91	Yes	No	0	5	4
472	S:S:I96	S:S:K176	2.91	No	No	0	5	4
473	R:R:P56	S:S:F126	2.89	No	Yes	0	2	7
474	R:R:K165	R:R:K174	2.87	No	No	0	4	5
475	S:S:I177	S:S:L173	2.85	No	No	0	3	4
476	S:S:I180	S:S:L184	2.85	No	No	0	4	4
477	S:S:K254	S:S:L251	2.82	No	No	0	4	4
478	R:R:G127	R:R:W124	2.81	No	Yes	0	7	8
479	S:S:G127	S:S:W124	2.81	No	Yes	0	7	8
480	S:S:G319	S:S:W287	2.81	No	Yes	0	7	8
481	R:R:C345	R:R:F344	2.79	No	No	0	5	4
482	R:R:C345	R:R:F346	2.79	No	Yes	0	5	4
483	S:S:C229	S:S:F225	2.79	No	No	0	3	4
484	R:R:A64	S:S:F70	2.77	No	Yes	0	5	7
485	R:R:F70	S:S:A64	2.77	Yes	No	0	7	5
486	R:R:D128	R:R:K132	2.77	No	No	0	2	6
487	R:R:A331	R:R:F341	2.77	No	Yes	0	7	6
488	S:S:A166	S:S:R170	2.77	No	Yes	0	5	6
489	S:S:A331	S:S:F341	2.77	No	Yes	0	7	6
490	L:L:?1	R:R:L135	2.7	Yes	No	0	0	4
491	R:R:F293	R:R:S311	2.64	No	No	0	5	4
492	S:S:F293	S:S:S311	2.64	Yes	No	0	5	4
493	R:R:S136	R:R:Y140	2.54	No	Yes	0	5	5
494	S:S:S211	S:S:Y219	2.54	No	No	0	4	1
495	R:R:F332	R:R:I328	2.51	No	No	0	6	7
496	S:S:F169	S:S:I158	2.51	No	No	0	4	5
497	S:S:F233	S:S:I237	2.51	No	No	0	4	5
498	S:S:F332	S:S:I328	2.51	No	No	0	6	7
499	R:R:F346	S:S:K338	2.48	Yes	No	0	4	8
500	R:R:L269	R:R:R156	2.43	No	Yes	0	6	9
501	R:R:E203	R:R:R202	2.33	No	No	0	1	2
502	S:S:L224	S:S:W221	2.28	Yes	No	0	3	1
503	R:R:F231	R:R:F235	2.14	No	Yes	0	5	8
504	R:R:G197	R:R:G198	2.11	No	No	0	4	4
505	S:S:G197	S:S:G198	2.11	No	No	0	4	4
506	R:R:A193	R:R:G190	1.95	No	No	0	5	6
507	S:S:A193	S:S:G190	1.95	No	No	0	5	6
508	R:R:G76	R:R:V75	1.84	No	No	0	7	4
509	S:S:G76	S:S:V75	1.84	No	No	0	7	4
510	S:S:P163	S:S:V164	1.77	No	No	0	8	5
511	R:R:P59	S:S:T117	1.75	No	No	0	4	4
512	R:R:T117	S:S:P59	1.75	No	No	0	4	4
513	S:S:G197	S:S:K132	1.74	No	No	0	4	6
514	R:R:A57	R:R:S55	1.71	No	No	0	4	1
515	R:R:G319	R:R:L318	1.71	No	No	0	7	8
516	S:S:G300	S:S:L299	1.71	No	No	0	2	4
517	S:S:A308	S:S:S311	1.71	No	No	0	3	4
518	R:R:I96	R:R:P172	1.69	Yes	No	0	5	2
519	R:R:C181	R:R:I177	1.64	No	No	0	4	3
520	S:S:G198	S:S:Q213	1.64	No	No	0	4	4
521	R:R:A57	R:R:I61	1.62	No	No	0	4	5
522	R:R:S123	R:R:V207	1.62	No	No	0	4	3
523	R:R:S188	R:R:V189	1.62	No	Yes	0	4	5
524	R:R:S192	R:R:V189	1.62	No	Yes	0	7	5
525	S:S:S123	S:S:V207	1.62	No	Yes	0	4	3
526	S:S:S188	S:S:V189	1.62	No	No	0	4	5
527	S:S:S192	S:S:V189	1.62	No	No	0	7	5
528	R:R:A106	R:R:M81	1.61	No	Yes	0	8	7
529	R:R:D266	R:R:P163	1.61	No	No	0	3	8
530	R:R:A298	R:R:K227	1.61	No	Yes	0	4	4
531	S:S:A106	S:S:M81	1.61	No	No	0	8	7
532	R:R:V65	R:R:V69	1.6	No	No	0	5	7
533	R:R:V68	R:R:V72	1.6	No	No	0	5	5
534	R:R:V68	S:S:V71	1.6	No	No	0	5	5
535	R:R:V71	S:S:V68	1.6	No	No	0	5	5
536	R:R:V239	R:R:V284	1.6	No	No	0	6	6
537	S:S:V65	S:S:V69	1.6	No	Yes	0	5	7
538	S:S:V68	S:S:V72	1.6	No	No	0	5	5
539	S:S:V239	S:S:V284	1.6	No	No	0	6	6
540	R:R:A298	R:R:L224	1.58	No	No	0	4	3
541	S:S:A298	S:S:L224	1.58	No	Yes	0	4	3
542	R:R:T110	R:R:T111	1.57	No	Yes	0	4	7
543	S:S:T110	S:S:T111	1.57	No	Yes	0	4	7
544	S:S:I58	S:S:S55	1.55	No	No	0	4	1
545	R:R:I191	R:R:V195	1.54	No	No	0	4	4
546	R:R:I208	R:R:V201	1.54	No	No	0	4	2
547	S:S:I61	S:S:V65	1.54	No	No	0	5	5
548	S:S:I133	S:S:V129	1.54	No	No	0	5	1
549	S:S:I191	S:S:V195	1.54	No	No	0	4	4
550	S:S:I208	S:S:V201	1.54	No	No	0	4	2
551	R:R:M81	R:R:S78	1.53	Yes	No	0	7	4
552	S:S:H162	S:S:P163	1.53	Yes	No	0	6	8
553	R:R:I243	R:R:T247	1.52	No	No	0	5	4
554	R:R:I292	R:R:T288	1.52	No	No	0	5	5
555	R:R:K91	R:R:T88	1.5	No	No	0	7	6
556	R:R:L259	R:R:S255	1.5	No	No	0	3	4
557	R:R:L240	R:R:V236	1.49	No	No	0	3	4
558	R:R:L248	R:R:V244	1.49	No	No	0	4	4
559	S:S:I133	S:S:I137	1.47	No	No	0	5	5
560	S:S:L173	S:S:T171	1.47	No	No	0	4	7
561	R:R:I84	R:R:K91	1.45	No	No	0	7	7
562	R:R:I96	R:R:K91	1.45	Yes	No	0	5	7
563	R:R:F346	R:R:P347	1.44	Yes	No	0	4	4
564	R:R:I137	R:R:L107	1.43	No	No	0	5	6
565	R:R:I250	R:R:L251	1.43	No	No	0	5	4
566	S:S:I137	S:S:L107	1.43	No	No	0	5	6
567	S:S:I250	S:S:L251	1.43	No	No	0	5	4
568	R:R:L248	R:R:L251	1.38	No	No	0	4	4
569	S:S:L224	S:S:L299	1.38	Yes	No	0	3	4
570	S:S:D168	S:S:L167	1.36	No	No	0	4	5
571	S:S:D266	S:S:N268	1.35	No	No	0	3	5
572	R:R:D204	R:R:E203	1.3	No	No	0	2	1
573	S:S:R270	S:S:T273	1.29	No	No	0	5	6
574	R:R:K265	R:R:R267	1.24	No	No	0	4	4
575	S:S:K254	S:S:R257	1.24	No	No	0	4	4
576	R:R:F147	R:R:L185	1.22	No	No	0	6	4
577	R:R:I158	R:R:Y157	1.21	No	Yes	0	5	7
578	S:S:D168	S:S:F169	1.19	No	No	0	4	4
579	R:R:E264	R:R:R267	1.16	No	No	0	3	4
580	S:S:D216	S:S:Y219	1.15	No	No	0	2	1
581	R:R:D218	R:R:W221	1.12	No	No	0	4	1
582	S:S:R339	S:S:R342	1.07	No	Yes	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F70	3.93	6	1	7
2	R:R:M81	3.09	4	0	7
3	R:R:I96	3.034	5	0	5
4	R:R:Y97	6.522	5	0	7
5	R:R:N100	9.602	5	4	9
6	R:R:T111	4.215	4	1	7
7	R:R:M112	7.902	5	1	7
8	R:R:W124	9.60167	6	1	8
9	R:R:F126	11.062	5	0	7
10	R:R:Y140	7.2475	4	0	5
11	R:R:T144	7.08	4	4	7
12	R:R:R156	6.68167	6	6	9
13	R:R:Y157	6.876	5	0	7
14	R:R:W183	9.795	4	4	9
15	R:R:V189	4.3675	4	0	5
16	R:R:F214	6.828	5	0	6
17	R:R:W222	8.56	4	8	7
18	R:R:K227	7.38	4	0	4
19	R:R:F235	7.4275	4	0	8
20	R:R:Y246	8.7825	4	0	8
21	R:R:F283	9.378	5	1	9
22	R:R:W287	7.42375	8	1	8
23	R:R:I316	6.96	4	1	5
24	R:R:Y320	10.5725	4	1	6
25	R:R:N322	7.86	4	1	9
26	R:R:N326	6.8425	4	0	9
27	R:R:Y330	7.1775	4	0	9
28	R:R:E335	5.865	4	0	4
29	R:R:F337	7.30667	6	5	8
30	R:R:F341	6.235	4	0	6
31	R:R:F346	3.482	5	0	4
32	S:S:V69	3.9475	4	0	7
33	S:S:F70	4.234	5	0	7
34	S:S:Y97	6.4	6	3	7
35	S:S:D105	7.945	4	2	9
36	S:S:T111	4.455	4	2	7
37	S:S:M112	9.28	4	0	7
38	S:S:W124	9.49571	7	2	8
39	S:S:F126	10.6967	6	0	7
40	S:S:Y140	6.7225	4	0	5
41	S:S:M142	6.8975	4	2	7
42	S:S:F143	7.2375	4	0	6
43	S:S:T144	7.7275	4	0	7
44	S:S:R156	5.84667	6	3	9
45	S:S:Y157	7.2525	4	10	7
46	S:S:C161	5.3675	4	10	7
47	S:S:H162	6.6125	4	10	6
48	S:S:R170	6.62	6	3	6
49	S:S:R202	6.3575	4	11	2
50	S:S:V207	4.13	4	11	3
51	S:S:F214	6.198	5	0	6
52	S:S:L224	2.7375	4	0	3
53	S:S:K227	8.1825	4	0	4
54	S:S:F235	7.7225	4	0	8
55	S:S:Y246	10.5725	4	0	8
56	S:S:F283	10.162	5	2	9
57	S:S:W287	7.26667	6	2	8
58	S:S:F293	4.1625	4	0	5
59	S:S:N322	6.682	5	2	9
60	S:S:N326	6.026	5	2	9
61	S:S:Y330	7.005	4	0	9
62	S:S:F337	7.00333	6	9	8
63	S:S:F341	5.2	4	0	6
64	S:S:R342	8.015	4	0	5
65	L:L:?1	9.20231	13	1	0
66	M:M:?1	9.40692	13	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F70	R:R:M112	72.2332	4.98	Yes	Yes	1	7	7
2	R:R:F70	S:S:S67	90.871	3.96	Yes	No	0	7	4
3	R:R:S67	S:S:S67	90.9679	6.52	No	No	0	4	4
4	R:R:S67	S:S:F70	91.0902	3.96	No	Yes	0	4	7
5	S:S:F70	S:S:M112	91.9466	6.22	Yes	Yes	0	7	7
6	S:S:M112	S:S:Y320	100	17.96	Yes	No	0	7	6
7	M:M:?1	S:S:Y320	97.5771	15.98	Yes	No	2	0	6
8	M:M:?1	S:S:V134	34.9766	3.87	Yes	No	0	0	6
9	S:S:V134	S:S:W124	34.0329	7.36	No	Yes	0	6	8
10	S:S:F126	S:S:W124	44.4933	19.04	Yes	Yes	0	7	8
11	M:M:?1	S:S:C210	35.976	4.12	Yes	No	2	0	9
12	S:S:C210	S:S:W124	34.0313	20.89	No	Yes	2	9	8
13	R:R:F70	R:R:P113	19.8135	4.33	Yes	No	0	7	8
14	S:S:M112	S:S:V69	13.9366	4.56	Yes	Yes	0	7	7
15	R:R:F341	R:R:L79	79.5526	6.09	Yes	No	0	6	6
16	R:R:F344	R:R:L79	79.4938	4.87	No	No	0	4	6
17	R:R:C345	R:R:F344	79.1316	2.79	No	No	0	5	4
18	R:R:C345	R:R:F346	79.0696	2.79	No	Yes	0	5	4
19	R:R:F346	S:S:F341	78.6629	4.29	Yes	Yes	0	4	6
20	S:S:F337	S:S:F341	78.8218	6.43	Yes	Yes	0	8	6
21	S:S:F337	S:S:Y330	80.5503	5.16	Yes	Yes	0	8	9
22	S:S:N326	S:S:Y330	94.7062	8.14	Yes	Yes	0	9	9
23	S:S:N322	S:S:N326	91.8608	6.81	Yes	Yes	2	9	9
24	S:S:N322	S:S:W287	92.6694	4.52	Yes	Yes	2	9	8
25	M:M:?1	S:S:W287	96.3983	5.17	Yes	Yes	2	0	8
26	R:R:M112	R:R:Y320	71.5961	17.96	Yes	Yes	1	7	6
27	L:L:?1	R:R:Y320	62.4511	13.7	Yes	Yes	1	0	6
28	L:L:?1	R:R:W287	35.0195	5.91	Yes	Yes	1	0	8
29	R:R:N322	R:R:W287	25.9922	6.78	Yes	Yes	1	9	8
30	R:R:N322	R:R:N326	28.6629	9.54	Yes	Yes	0	9	9
31	R:R:N326	R:R:Y330	30.4566	8.14	Yes	Yes	0	9	9
32	R:R:N100	R:R:W183	15.3459	10.17	Yes	Yes	4	9	9
33	R:R:I182	R:R:N100	35.7949	4.25	No	Yes	4	7	9
34	R:R:F147	R:R:I182	36.6464	7.54	No	No	0	6	7
35	R:R:F143	R:R:F147	37.2216	4.29	No	No	0	6	6
36	R:R:F143	R:R:V189	38.1176	9.18	No	Yes	0	6	5
37	R:R:V189	R:R:Y139	40.415	5.05	Yes	No	0	5	5
38	L:L:?1	R:R:Y139	41.1776	6.09	Yes	No	0	0	5
39	R:R:F337	R:R:F341	80.0292	9.65	Yes	Yes	0	8	6
40	R:R:A175	R:R:Y97	23.331	6.67	No	Yes	0	7	7
41	R:R:A175	R:R:I96	23.9125	4.87	No	Yes	0	7	5
42	R:R:I96	R:R:K91	60.0172	1.45	Yes	No	0	5	7
43	R:R:I84	R:R:K91	61.4312	1.45	No	No	0	7	7
44	R:R:F337	R:R:I84	62.1366	3.77	Yes	No	0	8	7
45	R:R:N179	R:R:Y97	44.6395	4.65	No	Yes	0	7	7
46	R:R:I96	R:R:N179	34.6811	4.25	Yes	No	0	5	7
47	R:R:N100	R:R:N179	33.2512	20.43	Yes	No	0	9	7
48	R:R:M152	R:R:Y97	57.356	5.99	No	Yes	0	8	7
49	R:R:M152	R:R:V276	55.6687	6.09	No	No	0	8	8
50	R:R:R156	R:R:V276	19.5021	6.54	Yes	No	0	9	8
51	R:R:F337	R:R:I98	34.2998	3.77	Yes	No	0	8	8
52	R:R:F114	R:R:P113	18.946	5.78	No	No	0	5	8
53	R:R:F114	R:R:F126	19.2669	16.08	No	Yes	0	5	7
54	L:L:?1	R:R:I316	10.5986	4.63	Yes	Yes	1	0	5
55	R:R:I316	R:R:Y312	15.5699	13.3	Yes	No	0	5	4
56	S:S:I316	S:S:Y312	11.7696	10.88	No	No	0	5	4
57	S:S:I316	S:S:Q115	12.8197	5.49	No	No	0	5	7
58	M:M:?1	S:S:Q115	13.8826	7.78	Yes	No	0	0	7
59	R:R:M121	R:R:P125	23.4772	6.71	No	No	0	4	1
60	R:R:F126	R:R:P125	24.7514	13	Yes	No	0	7	1
61	R:R:S123	R:R:V207	10.5605	1.62	No	No	0	4	3
62	R:R:M121	R:R:S123	22.1998	3.07	No	No	0	4	4
63	R:R:F126	R:R:W124	23.76	15.03	Yes	Yes	0	7	8
64	L:L:?1	R:R:C210	13.7571	4.12	Yes	No	1	0	9
65	L:L:?1	R:R:V134	12.8467	3.87	Yes	No	0	0	6
66	R:R:I208	R:R:S123	10.5605	3.1	No	No	0	4	4
67	R:R:H291	R:R:W287	13.1963	4.23	No	Yes	1	8	8
68	R:R:V276	R:R:Y246	35.1737	3.79	No	Yes	0	8	8
69	R:R:M249	R:R:Y157	21.2561	3.59	No	Yes	0	8	7
70	R:R:M249	R:R:Y246	23.0069	3.59	No	Yes	0	8	8
71	R:R:F214	R:R:Y219	11.8347	12.38	Yes	No	0	6	1
72	R:R:D223	R:R:Y219	14.1638	12.64	No	No	0	4	1
73	R:R:D223	R:R:K227	15.3236	16.59	No	Yes	0	4	4
74	R:R:I294	R:R:K227	21.075	7.27	No	Yes	0	5	4
75	L:L:?1	R:R:I294	19.3448	10.19	Yes	No	0	0	5
76	R:R:F235	R:R:H291	20.074	15.84	Yes	No	0	8	8
77	R:R:L269	R:R:R156	10.6844	2.43	No	Yes	0	6	9
78	R:R:D334	R:R:F337	10.6908	11.94	No	Yes	0	8	8
79	S:S:I98	S:S:Y330	77.7557	9.67	No	Yes	0	8	9
80	S:S:I98	S:S:M152	77.0217	4.37	No	No	0	8	8
81	S:S:M152	S:S:Y97	43.359	7.18	No	Yes	0	8	7
82	S:S:M152	S:S:V276	35.466	7.61	No	No	0	8	8
83	S:S:R156	S:S:V276	17.2365	5.23	Yes	No	0	9	8
84	S:S:N179	S:S:Y97	25.4854	4.65	No	Yes	0	7	7
85	S:S:M151	S:S:Y97	14.1956	5.99	No	Yes	3	6	7
86	S:S:N100	S:S:N179	16.906	20.43	No	No	0	9	7
87	S:S:N100	S:S:W183	11.9666	9.04	No	No	0	9	9
88	S:S:F126	S:S:P125	20.414	14.45	Yes	No	0	7	1
89	S:S:M121	S:S:P125	18.3868	6.71	No	No	0	4	1
90	S:S:T199	S:S:W124	18.3868	4.85	No	Yes	0	4	8
91	S:S:D128	S:S:T199	12.2859	14.45	No	No	0	2	4
92	S:S:D128	S:S:G198	10.2459	5.03	No	No	0	2	4
93	M:M:?1	S:S:Y139	13.1152	4.57	Yes	No	0	0	5
94	S:S:L212	S:S:Y139	12.0397	5.86	No	No	0	4	5
95	S:S:H291	S:S:W287	11.3056	4.23	No	Yes	2	8	8
96	S:S:V276	S:S:Y246	18.7855	7.57	No	Yes	0	8	8
97	S:S:M151	S:S:V154	13.263	4.56	No	No	0	6	6
98	S:S:R156	S:S:T273	12.3717	6.47	Yes	No	0	9	6
99	S:S:M249	S:S:Y246	12.2573	10.78	No	Yes	0	8	8
100	S:S:M249	S:S:V160	11.3152	4.56	No	No	0	8	8
101	S:S:C245	S:S:V154	12.3002	3.42	No	No	0	7	6
102	S:S:C245	S:S:Y157	11.3565	4.03	No	Yes	0	7	7
103	S:S:M121	S:S:S123	16.3563	3.07	No	No	0	4	4
104	S:S:S123	S:S:V207	14.3227	1.62	No	Yes	0	4	3
105	S:S:F214	S:S:L212	10.9609	7.31	Yes	No	0	6	4
106	M:M:?1	S:S:I294	17.0729	9.26	Yes	No	2	0	5
107	S:S:I294	S:S:K227	16.0529	7.27	No	Yes	0	5	4
108	S:S:F235	S:S:H291	15.9019	13.58	Yes	No	0	8	8
109	S:S:L269	S:S:T273	10.3413	5.9	No	No	0	6	6
110	R:R:I98	R:R:Y330	33.9916	12.09	No	Yes	0	8	9
111	R:R:V134	R:R:W124	11.992	7.36	No	Yes	0	6	8
112	R:R:C210	R:R:W124	11.9904	23.51	No	Yes	1	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:I137	S:S:T111	4.56	0	No	Yes	5	7	2	1
S:S:T111	S:S:Y320	4.99	2	Yes	No	7	6	1	1
M:M:?1	S:S:T111	6.7	2	Yes	Yes	0	7	0	1
S:S:M112	S:S:Y320	17.96	0	Yes	No	7	6	2	1
S:S:I316	S:S:Q115	5.49	0	No	No	5	7	2	1
M:M:?1	S:S:Q115	7.78	2	Yes	No	0	7	0	1
S:S:C131	S:S:W124	7.84	2	No	Yes	9	8	2	2
S:S:V134	S:S:W124	7.36	0	No	Yes	6	8	1	2
S:S:C210	S:S:W124	20.89	2	No	Yes	9	8	1	2
S:S:C131	S:S:C210	7.28	2	No	No	9	9	2	1
M:M:?1	S:S:V134	3.87	2	Yes	No	0	6	0	1
M:M:?1	S:S:D138	37	2	Yes	No	0	6	0	1
S:S:L212	S:S:Y139	5.86	0	No	No	4	5	2	1
M:M:?1	S:S:Y139	4.57	2	Yes	No	0	5	0	1
S:S:F143	S:S:M142	4.98	0	Yes	Yes	6	7	2	1
S:S:M142	S:S:W287	5.82	2	Yes	Yes	7	8	1	1
S:S:H291	S:S:M142	3.94	2	No	Yes	8	7	2	1
M:M:?1	S:S:M142	12.85	2	Yes	Yes	0	7	0	1
S:S:F143	S:S:V230	6.55	0	Yes	No	6	5	2	1
M:M:?1	S:S:C210	4.12	2	Yes	No	0	9	0	1
S:S:I294	S:S:K227	7.27	2	No	Yes	5	4	1	2
M:M:?1	S:S:V230	6.77	2	Yes	No	0	5	0	1
S:S:F283	S:S:W287	21.05	2	Yes	Yes	9	8	2	1
S:S:F283	S:S:N322	9.67	2	Yes	Yes	9	9	2	2
S:S:H291	S:S:W287	4.23	2	No	Yes	8	8	2	1
S:S:N322	S:S:W287	4.52	2	Yes	Yes	9	8	2	1
M:M:?1	S:S:W287	5.17	2	Yes	Yes	0	8	0	1
S:S:I290	S:S:I294	4.42	2	No	No	6	5	1	1
M:M:?1	S:S:I290	4.63	2	Yes	No	0	6	0	1
M:M:?1	S:S:I294	9.26	2	Yes	No	0	5	0	1
M:M:?1	S:S:Y320	15.98	2	Yes	No	0	6	0	1
M:M:?1	S:S:L135	3.59	2	Yes	No	0	4	0	1
S:S:G319	S:S:W287	2.81	0	No	Yes	7	8	2	1
S:S:T110	S:S:T111	1.57	0	No	Yes	4	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I137	R:R:T111	4.56	0	No	Yes	5	7	2	1
R:R:T111	R:R:Y320	4.99	1	Yes	Yes	7	6	1	1
L:L:?1	R:R:T111	5.74	1	Yes	Yes	0	7	0	1
R:R:M112	R:R:Y320	17.96	1	Yes	Yes	7	6	2	1
R:R:I316	R:R:Q115	5.49	1	Yes	No	5	7	1	1
R:R:Q115	R:R:Y320	5.64	1	No	Yes	7	6	1	1
L:L:?1	R:R:Q115	9.5	1	Yes	No	0	7	0	1
R:R:C131	R:R:W124	5.22	1	No	Yes	9	8	2	2
R:R:V134	R:R:W124	7.36	0	No	Yes	6	8	1	2
R:R:C210	R:R:W124	23.51	1	No	Yes	9	8	1	2
R:R:C131	R:R:C210	7.28	1	No	No	9	9	2	1
L:L:?1	R:R:V134	3.87	1	Yes	No	0	6	0	1
L:L:?1	R:R:D138	33.47	1	Yes	No	0	6	0	1
R:R:V189	R:R:Y139	5.05	0	Yes	No	5	5	2	1
L:L:?1	R:R:Y139	6.09	1	Yes	No	0	5	0	1
R:R:N141	R:R:W287	4.52	0	No	Yes	8	8	2	1
R:R:M142	R:R:W287	6.98	1	No	Yes	7	8	1	1
R:R:H291	R:R:M142	5.25	1	No	No	8	7	2	1
L:L:?1	R:R:M142	11.01	1	Yes	No	0	7	0	1
L:L:?1	R:R:C210	4.12	1	Yes	No	0	9	0	1
R:R:I294	R:R:K227	7.27	0	No	Yes	5	4	1	2
L:L:?1	R:R:V230	8.7	1	Yes	No	0	5	0	1
R:R:F283	R:R:W287	22.05	1	Yes	Yes	9	8	2	1
R:R:F283	R:R:N322	7.25	1	Yes	Yes	9	9	2	2
R:R:I290	R:R:W287	4.7	0	No	Yes	6	8	2	1
R:R:H291	R:R:W287	4.23	1	No	Yes	8	8	2	1
R:R:G319	R:R:W287	4.22	0	No	Yes	7	8	2	1
R:R:N322	R:R:W287	6.78	1	Yes	Yes	9	8	2	1
L:L:?1	R:R:W287	5.91	1	Yes	Yes	0	8	0	1
R:R:I290	R:R:I294	4.42	0	No	No	6	5	2	1
R:R:I290	R:R:I316	4.42	0	No	Yes	6	5	2	1
L:L:?1	R:R:I294	10.19	1	Yes	No	0	5	0	1
R:R:I316	R:R:Y312	13.3	1	Yes	No	5	4	1	2
L:L:?1	R:R:I316	4.63	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y320	13.7	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L135	2.7	1	Yes	No	0	4	0	1
R:R:T110	R:R:T111	1.57	0	No	Yes	4	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	4DJH_poly
Class	A
SubFamily	Peptide
Type	Opioid
SubType	KOP
Species	Homo sapiens
Ligand	JDTic
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	2.9
Date	2012-03-21
D.O.I.	10.1038/nature10939

Net Summary
I_min	3.79
Number of Linked Nodes	545
Number of Links	582
Number of Hubs	66
Number of Links mediated by Hubs	281
Number of Communities	12
Number of Nodes involved in Communities	70
Number of Links involved in Communities	87

Path Summary
Number Of Nodes in MetaPath	113
Number Of Links MetaPath	112
Number of Shortest Paths	211301
Length Of Smallest Path	3
Average Path Length	16.8539
Length of Longest Path	36
Minimum Path Strength	1.2
Average Path Strength	7.1497
Maximum Path Strength	26.49
Minimum Path Correlation	0.7
Average Path Correlation	0.961486
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	57.0211
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.9167
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	JDC
PDB Residues	L:L:?1 M:M:?1
Environment Details	Open EMBL-EBI Page
Code	JDC
Name	(3R)-7-hydroxy-N-{(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
Synonyms
Identifier	(3R)-N-[(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-piperidin-1-yl]-3-methyl-butan-2-yl]-7-oxidanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
Formula	C28 H39 N3 O3
Molecular Weight	465.628
SMILES	C[C@H]1CN(CC[C@@]1(C)c2cccc(c2)O)C[C@H](C(C)C)NC(=O)[C@H]3Cc4ccc(cc4CN3)O
PubChem	9956146
Formal Charge	0
Total Atoms	73
Total Chiral Atoms	4
Total Bonds	76
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41145
Sequence	>4DJH_poly_Chain_R S P A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T K M K T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N S W P F G D V L C K I V L S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H P V K A L D F R T P L K A K I I N I C I W L L S S S V G I S A I V L G G T K V R E D V D V I E C S L Q F P D D D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V R L L S G R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F K R C F R D F C F P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4DJH	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	2.9	2012-03-21	10.1038/nature10939
	6B73	A	Peptide	Opioid	κ	Homo sapiens	PubChem 131955138	-	-	3.1	2018-01-17	10.1016/j.cell.2017.12.011
	6VI4	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	3.3	2020-03-18	10.1038/s41467-020-14889-7
	7Y1F	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/&β;1/&γ;2	3.3	2023-05-24	10.1093/procel/pwac033
	7YIT	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-	-	3.3	2023-04-12	10.1038/s41467-023-37041-7
	8DZP	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Gi1/&β;1/&γ;2	2.71	2023-05-03	10.1038/s41586-023-06030-7
	8DZQ	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Go/&β;1/&γ;2	2.82	2023-05-03	10.1038/s41586-023-06030-7
	8DZR	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gt3)/&β;1/&γ;2	2.61	2023-05-03	10.1038/s41586-023-06030-7
	8DZS	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gz)/&β;1/&γ;2	2.65	2023-05-03	10.1038/s41586-023-06030-7
	8F7W	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/&β;1/&γ;2	3.19	2022-12-14	10.1016/j.cell.2022.12.026
	8FEG	A	Peptide	Opioid	κ	Homo sapiens	PRD_002517	-	Gi1/&β;1/&γ;2	2.54	2023-12-06	10.1038/s41467-023-43718-w
	4DJH (Dimer)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	2.9	2012-03-21	10.1038/nature10939

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 4DJH_poly.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.