psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:T111	5.74	Yes	Yes	2	0	7
2	L:L:?1	R:R:Q115	9.5	Yes	No	2	0	7
3	L:L:?1	R:R:D138	33.47	Yes	No	0	0	6
4	L:L:?1	R:R:Y139	6.09	Yes	No	0	0	5
5	L:L:?1	R:R:M142	11.01	Yes	No	2	0	7
6	L:L:?1	R:R:C210	4.12	Yes	No	2	0	9
7	L:L:?1	R:R:V230	8.7	Yes	No	0	0	5
8	L:L:?1	R:R:W287	5.91	Yes	Yes	2	0	8
9	L:L:?1	R:R:I294	10.19	Yes	No	0	0	5
10	L:L:?1	R:R:I316	4.63	Yes	Yes	2	0	5
11	L:L:?1	R:R:Y320	13.7	Yes	Yes	2	0	6
12	M:M:?1	S:S:T111	6.7	Yes	Yes	1	0	7
13	M:M:?1	S:S:Q115	7.78	Yes	No	0	0	7
14	M:M:?1	S:S:D138	37	Yes	No	0	0	6
15	M:M:?1	S:S:Y139	4.57	Yes	No	0	0	5
16	M:M:?1	S:S:M142	12.85	Yes	No	1	0	7
17	M:M:?1	S:S:C210	4.12	Yes	No	1	0	9
18	M:M:?1	S:S:V230	6.77	Yes	No	0	0	5
19	M:M:?1	S:S:W287	5.17	Yes	Yes	1	0	8
20	M:M:?1	S:S:I290	4.63	Yes	No	1	0	6
21	M:M:?1	S:S:I294	9.26	Yes	No	1	0	5
22	M:M:?1	S:S:Y320	15.98	Yes	No	1	0	6
23	R:R:P56	R:R:S55	5.34	No	No	0	2	1
24	R:R:I58	R:R:P59	6.77	No	No	0	4	4
25	R:R:V60	S:S:F114	10.49	No	No	0	5	5
26	R:R:M112	R:R:Y66	5.99	Yes	No	0	7	6
27	R:R:S116	R:R:Y66	8.9	No	No	0	6	6
28	R:R:S67	S:S:S67	6.52	No	No	0	4	4
29	R:R:S67	S:S:F70	3.96	No	Yes	0	4	7
30	R:R:M112	R:R:V69	4.56	Yes	No	0	7	7
31	R:R:S324	R:R:V69	8.08	No	No	0	7	7
32	R:R:F70	R:R:M112	4.98	Yes	Yes	0	7	7
33	R:R:F70	R:R:P113	4.33	Yes	No	0	7	8
34	R:R:F70	S:S:S67	3.96	Yes	No	0	7	4
35	R:R:V71	S:S:V71	11.22	No	No	0	5	5
36	R:R:G76	R:R:P327	4.06	No	No	0	7	9
37	R:R:A102	R:R:N77	4.69	No	No	0	8	9
38	R:R:D105	R:R:N77	5.39	No	No	0	9	9
39	R:R:N77	R:R:P327	11.4	No	No	0	9	9
40	R:R:F341	R:R:L79	6.09	Yes	No	0	6	6
41	R:R:F344	R:R:L79	4.87	No	No	0	4	6
42	R:R:F99	R:R:M81	4.98	No	Yes	0	5	7
43	R:R:L103	R:R:M81	4.24	No	Yes	0	6	7
44	R:R:F82	R:R:R86	4.28	No	No	0	4	5
45	R:R:F344	R:R:F82	7.5	No	No	0	4	4
46	R:R:C340	R:R:V83	5.12	No	No	0	6	8
47	R:R:R86	R:R:Y87	4.12	No	No	0	5	5
48	R:R:C340	R:R:Y87	4.03	No	No	0	6	5
49	R:R:M90	R:R:N95	5.61	No	No	5	7	7
50	R:R:F337	R:R:M90	7.46	Yes	No	5	8	7
51	R:R:N95	R:R:T92	5.85	No	No	0	7	7
52	R:R:A93	R:R:D155	4.63	No	No	0	6	8
53	R:R:R156	R:R:T94	6.47	Yes	No	6	9	8
54	R:R:I272	R:R:T94	4.56	No	No	6	7	8
55	R:R:F337	R:R:N95	7.25	Yes	No	5	8	7
56	R:R:A175	R:R:I96	4.87	No	Yes	0	7	5
57	R:R:I96	R:R:N179	4.25	Yes	No	0	5	7
58	R:R:M152	R:R:Y97	5.99	No	Yes	0	8	7
59	R:R:D155	R:R:Y97	8.05	No	Yes	0	8	7
60	R:R:A175	R:R:Y97	6.67	No	Yes	0	7	7
61	R:R:I178	R:R:Y97	7.25	No	Yes	0	6	7
62	R:R:N179	R:R:Y97	4.65	No	Yes	0	7	7
63	R:R:I98	R:R:Y330	12.09	No	Yes	0	8	9
64	R:R:N100	R:R:T144	4.39	Yes	Yes	4	9	7
65	R:R:N100	R:R:T148	8.77	Yes	No	4	9	7
66	R:R:N100	R:R:N179	20.43	Yes	No	0	9	7
67	R:R:I182	R:R:N100	4.25	No	Yes	4	7	9
68	R:R:N100	R:R:W183	10.17	Yes	Yes	4	9	9
69	R:R:L101	R:R:L149	6.92	No	No	0	9	8
70	R:R:L101	R:R:Y330	4.69	No	Yes	0	9	9
71	R:R:L103	R:R:W183	4.56	No	Yes	0	6	9
72	R:R:D105	R:R:S323	8.83	No	No	0	9	8
73	R:R:D105	R:R:N326	6.73	No	Yes	0	9	9
74	R:R:N141	R:R:V108	16.26	No	No	0	8	7
75	R:R:M112	R:R:T109	6.02	Yes	No	0	7	6
76	R:R:I137	R:R:T111	4.56	No	Yes	0	5	7
77	R:R:T111	R:R:Y320	4.99	Yes	Yes	2	7	6
78	R:R:M112	R:R:Y320	17.96	Yes	Yes	0	7	6
79	R:R:F114	R:R:P113	5.78	No	No	0	5	8
80	R:R:F114	R:R:F126	16.08	No	Yes	0	5	7
81	R:R:F114	S:S:V60	10.49	No	No	0	5	5
82	R:R:I316	R:R:Q115	5.49	Yes	No	2	5	7
83	R:R:Q115	R:R:Y320	5.64	No	Yes	2	7	6
84	R:R:Y119	R:R:Y313	10.92	No	No	0	4	4
85	R:R:L120	S:S:L120	6.92	No	No	0	4	4
86	R:R:M121	R:R:P125	6.71	No	No	0	4	1
87	R:R:N122	R:R:V207	4.43	No	No	0	5	3
88	R:R:F126	R:R:W124	15.03	Yes	Yes	0	7	8
89	R:R:C131	R:R:W124	5.22	No	Yes	2	9	8
90	R:R:V134	R:R:W124	7.36	No	Yes	0	6	8
91	R:R:C210	R:R:W124	23.51	No	Yes	2	9	8
92	R:R:F126	R:R:P125	13	Yes	No	0	7	1
93	R:R:F126	R:R:L130	7.31	Yes	No	0	7	5
94	R:R:D128	R:R:G198	5.03	No	No	0	2	4
95	R:R:D128	R:R:T199	5.78	No	No	0	2	4
96	R:R:C131	R:R:C210	7.28	No	No	2	9	9
97	R:R:I194	R:R:S136	6.19	No	No	0	4	5
98	R:R:V189	R:R:Y139	5.05	Yes	No	0	5	5
99	R:R:W183	R:R:Y140	8.68	Yes	Yes	0	9	5
100	R:R:S187	R:R:Y140	7.63	No	Yes	0	4	5
101	R:R:G190	R:R:Y140	10.14	No	Yes	0	6	5
102	R:R:N141	R:R:W287	4.52	No	Yes	0	8	8
103	R:R:M142	R:R:W287	6.98	No	Yes	2	7	8
104	R:R:H291	R:R:M142	5.25	No	No	2	8	7
105	R:R:F143	R:R:F147	4.29	No	No	0	6	6
106	R:R:F143	R:R:V189	9.18	No	Yes	0	6	5
107	R:R:A234	R:R:F143	8.32	No	No	0	6	6
108	R:R:T144	R:R:W183	15.77	Yes	Yes	4	7	9
109	R:R:S186	R:R:T144	4.8	No	Yes	0	8	7
110	R:R:F283	R:R:S145	3.96	Yes	No	0	9	9
111	R:R:I146	R:R:P238	6.77	No	No	0	7	9
112	R:R:F283	R:R:I146	7.54	Yes	No	0	9	7
113	R:R:F147	R:R:I182	7.54	No	No	0	6	7
114	R:R:I182	R:R:T148	4.56	No	No	4	7	7
115	R:R:F283	R:R:L149	6.09	Yes	No	0	9	8
116	R:R:I242	R:R:T150	7.6	No	No	0	8	7
117	R:R:I178	R:R:M151	5.83	No	No	0	6	6
118	R:R:M152	R:R:V276	6.09	No	No	0	8	8
119	R:R:I242	R:R:S153	7.74	No	No	0	8	9
120	R:R:S153	R:R:Y246	10.17	No	Yes	0	9	8
121	R:R:A159	R:R:R156	5.53	No	Yes	0	8	9
122	R:R:I272	R:R:R156	8.77	No	Yes	6	7	9
123	R:R:R156	R:R:T273	10.35	Yes	No	0	9	6
124	R:R:R156	R:R:V276	6.54	Yes	No	0	9	8
125	R:R:C245	R:R:Y157	4.03	No	Yes	0	7	7
126	R:R:L248	R:R:Y157	7.03	No	Yes	0	4	7
127	R:R:R252	R:R:Y157	18.52	No	Yes	0	5	7
128	R:R:R252	R:R:V160	6.54	No	No	0	5	8
129	R:R:L253	R:R:V160	4.47	No	No	0	8	8
130	R:R:C161	R:R:R252	8.36	No	No	0	7	5
131	R:R:K165	R:R:V164	6.07	No	No	0	4	5
132	R:R:D168	R:R:K165	4.15	No	No	0	4	4
133	R:R:D168	R:R:R170	7.15	No	No	0	4	6
134	R:R:D168	R:R:T171	4.34	No	No	0	4	7
135	R:R:P172	R:R:T171	5.25	No	No	0	2	7
136	R:R:K176	R:R:L173	4.23	No	No	0	4	4
137	R:R:I180	R:R:L184	4.28	No	No	0	4	4
138	R:R:F214	R:R:L196	4.87	Yes	No	0	6	4
139	R:R:G198	R:R:Q213	6.58	No	No	0	4	4
140	R:R:I208	R:R:T199	4.56	No	No	0	4	4
141	R:R:E209	R:R:R202	16.28	No	No	0	3	2
142	R:R:V205	R:R:V207	6.41	No	No	0	1	3
143	R:R:F214	R:R:Y219	12.38	Yes	No	0	6	1
144	R:R:F214	R:R:W222	7.02	Yes	Yes	0	6	7
145	R:R:F214	R:R:M226	6.22	Yes	No	0	6	5
146	R:R:P215	R:R:W222	5.4	No	Yes	0	5	7
147	R:R:D216	R:R:D217	6.65	No	No	0	2	1
148	R:R:D223	R:R:Y219	12.64	No	No	0	4	1
149	R:R:W221	R:R:W222	17.81	No	Yes	7	1	7
150	R:R:F225	R:R:W221	15.03	No	No	7	4	1
151	R:R:F225	R:R:W222	4.01	No	Yes	7	4	7
152	R:R:D223	R:R:K227	16.59	No	Yes	0	4	4
153	R:R:I228	R:R:L224	4.28	No	No	0	5	3
154	R:R:C229	R:R:F225	4.19	No	No	0	3	4
155	R:R:I294	R:R:K227	7.27	No	Yes	0	5	4
156	R:R:E297	R:R:K227	4.05	No	Yes	0	5	4
157	R:R:F231	R:R:V236	5.24	No	No	0	5	4
158	R:R:F231	R:R:L295	15.83	No	No	0	5	5
159	R:R:F233	R:R:I232	6.28	No	No	0	4	5
160	R:R:F235	R:R:V239	5.24	Yes	No	0	8	6
161	R:R:F235	R:R:T288	6.49	Yes	No	0	8	5
162	R:R:F235	R:R:H291	15.84	Yes	No	0	8	8
163	R:R:I237	R:R:P238	5.08	No	No	0	5	9
164	R:R:L277	R:R:Y246	17.58	No	Yes	0	4	8
165	R:R:K265	R:R:R257	8.66	No	No	0	4	4
166	R:R:K265	R:R:S260	4.59	No	No	0	4	4
167	R:R:D266	R:R:L269	5.43	No	No	0	3	6
168	R:R:N268	R:R:R271	6.03	No	Yes	0	5	7
169	R:R:I272	R:R:R271	6.26	No	Yes	0	7	7
170	R:R:R271	R:R:R274	5.33	Yes	No	0	7	6
171	R:R:D334	R:R:R271	10.72	Yes	Yes	0	8	7
172	R:R:L275	R:R:L333	4.15	No	No	0	8	7
173	R:R:D334	R:R:L275	4.07	Yes	No	0	8	8
174	R:R:L333	R:R:V278	4.47	No	No	0	7	5
175	R:R:F283	R:R:W287	22.05	Yes	Yes	2	9	8
176	R:R:F283	R:R:N322	7.25	Yes	Yes	2	9	9
177	R:R:C286	R:R:N322	7.87	No	Yes	0	8	9
178	R:R:I290	R:R:W287	4.7	No	Yes	0	6	8
179	R:R:H291	R:R:W287	4.23	No	Yes	2	8	8
180	R:R:G319	R:R:W287	4.22	No	Yes	0	7	8
181	R:R:N322	R:R:W287	6.78	Yes	Yes	2	9	8
182	R:R:I290	R:R:I294	4.42	No	No	0	6	5
183	R:R:I290	R:R:I316	4.42	No	Yes	0	6	5
184	R:R:F293	R:R:Y312	7.22	No	No	0	5	4
185	R:R:C315	R:R:F293	4.19	No	No	0	7	5
186	R:R:L295	R:R:L299	4.15	No	No	0	5	4
187	R:R:L309	R:R:Y313	8.21	No	No	0	4	4
188	R:R:Y312	R:R:Y313	6.95	No	No	0	4	4
189	R:R:I316	R:R:Y312	13.3	Yes	No	0	5	4
190	R:R:F314	R:R:L318	6.09	No	No	0	5	8
191	R:R:N322	R:R:N326	9.54	Yes	Yes	0	9	9
192	R:R:N326	R:R:Y330	8.14	Yes	Yes	0	9	9
193	R:R:D334	R:R:N336	8.08	Yes	No	0	8	6
194	R:R:D334	R:R:F337	11.94	Yes	Yes	0	8	8
195	R:R:E335	R:R:K338	10.8	No	No	0	4	8
196	R:R:E335	R:R:R339	9.3	No	No	0	4	5
197	R:R:F337	R:R:F341	9.65	Yes	Yes	0	8	6
198	R:R:K338	S:S:F346	4.96	No	Yes	0	8	4
199	R:R:R339	R:R:R342	8.53	No	No	0	5	5
200	R:R:F341	S:S:F346	6.43	Yes	Yes	0	6	4
201	R:R:R342	S:S:F346	6.41	No	Yes	0	5	4
202	R:R:F346	S:S:F341	4.29	Yes	Yes	0	4	6
203	R:R:F346	S:S:R342	6.41	Yes	No	0	4	5
204	S:S:I58	S:S:P59	6.77	No	No	0	4	4
205	S:S:M112	S:S:Y66	8.38	Yes	No	0	7	6
206	S:S:S116	S:S:Y66	7.63	No	No	0	6	6
207	S:S:M112	S:S:V69	4.56	Yes	Yes	0	7	7
208	S:S:S324	S:S:V69	6.46	No	Yes	0	7	7
209	S:S:F70	S:S:M112	6.22	Yes	Yes	0	7	7
210	S:S:F70	S:S:P113	4.33	Yes	No	0	7	8
211	S:S:G76	S:S:P327	4.06	No	No	0	7	9
212	S:S:A102	S:S:N77	4.69	No	No	0	8	9
213	S:S:D105	S:S:N77	8.08	Yes	No	0	9	9
214	S:S:N77	S:S:P327	11.4	No	No	0	9	9
215	S:S:F341	S:S:L79	7.31	Yes	No	0	6	6
216	S:S:F344	S:S:L79	9.74	No	No	0	4	6
217	S:S:V80	S:S:Y330	5.05	No	Yes	0	9	9
218	S:S:F99	S:S:M81	9.95	No	No	0	5	7
219	S:S:L103	S:S:M81	4.24	No	No	0	6	7
220	S:S:F344	S:S:F82	8.57	No	No	0	4	4
221	S:S:C340	S:S:V83	6.83	No	No	0	6	8
222	S:S:F99	S:S:I84	5.02	No	No	0	5	7
223	S:S:F337	S:S:I84	5.02	Yes	No	0	8	7
224	S:S:F99	S:S:I85	5.02	No	No	0	5	3
225	S:S:R86	S:S:Y87	10.29	No	No	0	5	5
226	S:S:K89	S:S:Y87	4.78	No	No	0	5	5
227	S:S:C340	S:S:Y87	4.03	No	No	0	6	5
228	S:S:M90	S:S:N95	7.01	No	No	8	7	7
229	S:S:F337	S:S:M90	6.22	Yes	No	8	8	7
230	S:S:N95	S:S:T92	10.24	No	No	0	7	7
231	S:S:A93	S:S:D155	4.63	No	No	3	6	8
232	S:S:A93	S:S:R170	5.53	No	Yes	3	6	6
233	S:S:F337	S:S:N95	7.25	Yes	No	8	8	7
234	S:S:I96	S:S:N179	4.25	No	No	0	5	7
235	S:S:M151	S:S:Y97	5.99	No	Yes	3	6	7
236	S:S:M152	S:S:Y97	7.18	No	Yes	0	8	7
237	S:S:D155	S:S:Y97	9.2	No	Yes	3	8	7
238	S:S:A175	S:S:Y97	5.34	No	Yes	0	7	7
239	S:S:I178	S:S:Y97	6.04	No	Yes	3	6	7
240	S:S:N179	S:S:Y97	4.65	No	Yes	0	7	7
241	S:S:I98	S:S:M152	4.37	No	No	0	8	8
242	S:S:I98	S:S:Y330	9.67	No	Yes	0	8	9
243	S:S:N100	S:S:T148	8.77	No	No	0	9	7
244	S:S:N100	S:S:N179	20.43	No	No	0	9	7
245	S:S:N100	S:S:W183	9.04	No	No	0	9	9
246	S:S:D105	S:S:L101	8.14	Yes	No	1	9	9
247	S:S:L101	S:S:N326	5.49	No	Yes	1	9	9
248	S:S:D105	S:S:S323	8.83	Yes	No	0	9	8
249	S:S:D105	S:S:N326	6.73	Yes	Yes	1	9	9
250	S:S:N141	S:S:V108	16.26	No	No	0	8	7
251	S:S:I137	S:S:T111	4.56	No	Yes	0	5	7
252	S:S:T111	S:S:Y320	4.99	Yes	No	1	7	6
253	S:S:M112	S:S:Y320	17.96	Yes	No	0	7	6
254	S:S:F114	S:S:F126	13.93	No	Yes	0	5	7
255	S:S:I316	S:S:Q115	5.49	No	No	0	5	7
256	S:S:F126	S:S:T117	7.78	Yes	No	0	7	4
257	S:S:Y119	S:S:Y313	16.88	No	No	0	4	4
258	S:S:M121	S:S:P125	6.71	No	No	0	4	1
259	S:S:F126	S:S:W124	19.04	Yes	Yes	0	7	8
260	S:S:C131	S:S:W124	7.84	No	Yes	1	9	8
261	S:S:V134	S:S:W124	7.36	No	Yes	0	6	8
262	S:S:T199	S:S:W124	4.85	No	Yes	0	4	8
263	S:S:C210	S:S:W124	20.89	No	Yes	1	9	8
264	S:S:F126	S:S:P125	14.45	Yes	No	0	7	1
265	S:S:F126	S:S:L130	6.09	Yes	No	0	7	5
266	S:S:D128	S:S:G198	5.03	No	No	0	2	4
267	S:S:D128	S:S:T199	14.45	No	No	0	2	4
268	S:S:C131	S:S:C210	7.28	No	No	1	9	9
269	S:S:I133	S:S:K132	4.36	No	No	0	5	6
270	S:S:I194	S:S:K132	4.36	No	No	0	4	6
271	S:S:I194	S:S:S136	6.19	No	No	0	4	5
272	S:S:L212	S:S:Y139	5.86	No	No	0	4	5
273	S:S:W183	S:S:Y140	6.75	No	Yes	0	9	5
274	S:S:S187	S:S:Y140	7.63	No	Yes	0	4	5
275	S:S:G190	S:S:Y140	8.69	No	Yes	0	6	5
276	S:S:F143	S:S:M142	4.98	Yes	No	0	6	7
277	S:S:M142	S:S:W287	5.82	No	Yes	1	7	8
278	S:S:F143	S:S:V189	10.49	Yes	No	0	6	5
279	S:S:F143	S:S:V230	6.55	Yes	No	0	6	5
280	S:S:A234	S:S:F143	6.93	No	Yes	0	6	6
281	S:S:I182	S:S:T144	4.56	No	Yes	0	7	7
282	S:S:T144	S:S:W183	18.19	Yes	No	0	7	9
283	S:S:S186	S:S:T144	4.8	No	Yes	0	8	7
284	S:S:F283	S:S:S145	5.28	Yes	No	0	9	9
285	S:S:I146	S:S:P238	6.77	No	No	0	7	9
286	S:S:F283	S:S:I146	6.28	Yes	No	0	9	7
287	S:S:F147	S:S:I182	7.54	No	No	0	6	7
288	S:S:F147	S:S:L185	6.09	No	No	0	6	4
289	S:S:I182	S:S:T148	4.56	No	No	0	7	7
290	S:S:F283	S:S:L149	8.53	Yes	No	0	9	8
291	S:S:I241	S:S:T150	4.56	No	No	0	6	7
292	S:S:I242	S:S:T150	7.6	No	No	0	8	7
293	S:S:M151	S:S:V154	4.56	No	No	0	6	6
294	S:S:I178	S:S:M151	5.83	No	No	3	6	6
295	S:S:M152	S:S:V276	7.61	No	No	0	8	8
296	S:S:I242	S:S:S153	9.29	No	No	0	8	9
297	S:S:S153	S:S:Y246	6.36	No	Yes	0	9	8
298	S:S:D155	S:S:R170	16.68	No	Yes	3	8	6
299	S:S:A159	S:S:R156	4.15	No	Yes	3	8	9
300	S:S:R156	S:S:R170	5.33	Yes	Yes	3	9	6
301	S:S:I272	S:S:R156	10.02	No	Yes	0	7	9
302	S:S:R156	S:S:T273	6.47	Yes	No	0	9	6
303	S:S:R156	S:S:V276	5.23	Yes	No	0	9	8
304	S:S:C161	S:S:Y157	8.06	Yes	Yes	9	7	7
305	S:S:H162	S:S:Y157	8.71	Yes	Yes	9	6	7
306	S:S:C245	S:S:Y157	4.03	No	Yes	0	7	7
307	S:S:L248	S:S:Y157	8.21	No	Yes	0	4	7
308	S:S:A159	S:S:R170	5.53	No	Yes	3	8	6
309	S:S:M249	S:S:V160	4.56	No	No	0	8	8
310	S:S:L253	S:S:V160	4.47	No	No	0	8	8
311	S:S:C161	S:S:H162	4.42	Yes	Yes	9	7	6
312	S:S:C161	S:S:R252	5.57	Yes	No	0	7	5
313	S:S:H162	S:S:K165	13.1	Yes	No	0	6	4
314	S:S:F169	S:S:K165	12.41	No	No	0	4	4
315	S:S:K174	S:S:T171	4.5	No	No	0	5	7
316	S:S:I191	S:S:S187	6.19	No	No	0	4	4
317	S:S:I208	S:S:T199	4.56	No	No	0	4	4
318	S:S:K200	S:S:Q213	14.92	No	No	0	2	4
319	S:S:E209	S:S:R202	5.82	No	No	0	3	2
320	S:S:V205	S:S:V207	8.02	No	No	0	1	3
321	S:S:F214	S:S:L212	7.31	Yes	No	0	6	4
322	S:S:F214	S:S:Y219	9.28	Yes	No	0	6	1
323	S:S:F214	S:S:W222	7.02	Yes	No	0	6	7
324	S:S:P215	S:S:W222	5.4	No	No	0	5	7
325	S:S:D216	S:S:D217	11.98	No	No	0	2	1
326	S:S:D218	S:S:W222	8.93	No	No	0	4	7
327	S:S:D223	S:S:K227	16.59	No	Yes	0	4	4
328	S:S:I228	S:S:L224	5.71	No	Yes	0	5	3
329	S:S:I294	S:S:K227	7.27	No	Yes	0	5	4
330	S:S:E297	S:S:K227	4.05	No	Yes	0	5	4
331	S:S:A298	S:S:K227	4.82	No	Yes	0	4	4
332	S:S:C229	S:S:F233	4.19	No	No	0	3	4
333	S:S:F231	S:S:F235	4.29	No	Yes	0	5	8
334	S:S:F231	S:S:V236	5.24	No	No	0	5	4
335	S:S:F231	S:S:L295	12.18	No	No	0	5	5
336	S:S:F235	S:S:V239	5.24	Yes	No	0	8	6
337	S:S:F235	S:S:T288	7.78	Yes	No	0	8	5
338	S:S:F235	S:S:H291	13.58	Yes	No	0	8	8
339	S:S:I237	S:S:P238	5.08	No	No	0	5	9
340	S:S:I242	S:S:V280	4.61	No	No	0	8	8
341	S:S:M249	S:S:Y246	10.78	No	Yes	0	8	8
342	S:S:V276	S:S:Y246	7.57	No	Yes	0	8	8
343	S:S:L277	S:S:Y246	17.58	No	Yes	0	4	8
344	S:S:N268	S:S:R257	21.69	No	Yes	0	5	4
345	S:S:L258	S:S:L259	4.15	No	No	0	5	3
346	S:S:D266	S:S:K265	4.15	No	No	0	3	4
347	S:S:R270	S:S:R271	7.46	No	No	0	5	7
348	S:S:E335	S:S:R271	4.65	No	No	0	4	7
349	S:S:L275	S:S:L333	6.92	No	No	0	8	7
350	S:S:L333	S:S:V278	4.47	No	No	0	7	5
351	S:S:F283	S:S:W287	21.05	Yes	Yes	1	9	8
352	S:S:F283	S:S:N322	9.67	Yes	Yes	1	9	9
353	S:S:C286	S:S:L318	4.76	No	No	0	8	8
354	S:S:C286	S:S:N322	9.45	No	Yes	0	8	9
355	S:S:H291	S:S:W287	4.23	No	Yes	0	8	8
356	S:S:N322	S:S:W287	4.52	Yes	Yes	1	9	8
357	S:S:I290	S:S:I294	4.42	No	No	1	6	5
358	S:S:E297	S:S:F293	4.66	No	Yes	0	5	5
359	S:S:F293	S:S:Y312	5.16	Yes	No	0	5	4
360	S:S:C315	S:S:F293	4.19	No	Yes	0	7	5
361	S:S:L309	S:S:Y313	4.69	No	No	0	4	4
362	S:S:Y312	S:S:Y313	8.94	No	No	0	4	4
363	S:S:I316	S:S:Y312	10.88	No	No	0	5	4
364	S:S:F314	S:S:L318	8.53	No	No	0	5	8
365	S:S:N322	S:S:N326	6.81	Yes	Yes	1	9	9
366	S:S:N326	S:S:Y330	8.14	Yes	Yes	0	9	9
367	S:S:F337	S:S:Y330	5.16	Yes	Yes	0	8	9
368	S:S:D334	S:S:N336	6.73	No	No	0	8	6
369	S:S:D334	S:S:F337	11.94	No	Yes	0	8	8
370	S:S:F337	S:S:F341	6.43	Yes	Yes	0	8	6
371	S:S:D343	S:S:R342	10.72	No	No	0	3	5
372	S:S:C345	S:S:F346	8.38	No	Yes	0	5	4
373	R:R:R263	R:R:S260	3.95	No	No	0	3	4
374	R:R:R202	R:R:V205	3.92	No	No	0	2	1
375	S:S:R202	S:S:V205	3.92	No	No	0	2	1
376	R:R:F126	R:R:T117	3.89	Yes	No	0	7	4
377	S:S:F70	S:S:T109	3.89	Yes	No	0	7	6
378	S:S:R156	S:S:T94	3.88	Yes	No	3	9	8
379	S:S:R170	S:S:T94	3.88	Yes	No	3	6	8
380	R:R:S211	R:R:Y219	3.82	No	No	0	4	1
381	S:S:S136	S:S:Y140	3.82	No	Yes	0	5	5
382	R:R:V80	R:R:Y330	3.79	No	Yes	0	9	9
383	R:R:V276	R:R:Y246	3.79	No	Yes	0	8	8
384	R:R:F337	R:R:I84	3.77	Yes	No	0	8	7
385	R:R:C315	R:R:P289	3.77	No	No	0	7	9
386	S:S:C315	S:S:P289	3.77	No	No	0	7	9
387	S:S:I272	S:S:R271	3.76	No	No	0	7	7
388	R:R:T63	S:S:Y66	3.75	No	No	0	5	6
389	R:R:Y66	S:S:T63	3.75	No	No	0	6	5
390	S:S:F214	S:S:M226	3.73	Yes	No	0	6	5
391	S:S:S220	S:S:W221	3.71	No	No	0	2	1
392	S:S:K254	S:S:R257	3.71	No	Yes	0	4	4
393	R:R:V118	R:R:W124	3.68	No	Yes	0	5	8
394	S:S:V118	S:S:W124	3.68	No	Yes	0	5	8
395	R:R:F70	R:R:L74	3.65	Yes	No	0	7	6
396	R:R:F214	R:R:L212	3.65	Yes	No	0	6	4
397	S:S:F214	S:S:L196	3.65	Yes	No	0	6	4
398	R:R:G73	R:R:T109	3.64	No	No	0	8	6
399	S:S:G73	S:S:T109	3.64	No	No	0	8	6
400	S:S:L253	S:S:R257	3.64	No	Yes	0	8	4
401	S:S:L269	S:S:R274	3.64	No	No	0	6	6
402	S:S:L333	S:S:R274	3.64	No	No	0	7	6
403	M:M:?1	S:S:L135	3.59	Yes	No	0	0	4
404	R:R:M249	R:R:Y157	3.59	No	Yes	0	8	7
405	R:R:M249	R:R:Y246	3.59	No	Yes	0	8	8
406	R:R:K89	R:R:Y87	3.58	No	No	0	5	5
407	S:S:P56	S:S:S55	3.56	No	No	0	2	1
408	S:S:L120	S:S:Y119	3.52	No	No	0	4	4
409	S:S:P172	S:S:T171	3.5	No	No	0	2	7
410	S:S:C245	S:S:V154	3.42	No	No	0	7	6
411	S:S:C161	S:S:V160	3.42	Yes	No	0	7	8
412	S:S:I96	S:S:P172	3.39	No	No	0	5	2
413	R:R:A104	R:R:T144	3.36	No	Yes	0	8	7
414	S:S:A104	S:S:T144	3.36	No	Yes	0	8	7
415	R:R:K338	S:S:P347	3.35	No	No	0	8	4
416	S:S:K91	S:S:P172	3.35	No	No	0	7	2
417	R:R:S310	R:R:S311	3.26	No	No	0	2	4
418	S:S:C340	S:S:M90	3.24	No	No	0	6	7
419	R:R:S324	R:R:V72	3.23	No	No	0	7	5
420	S:S:S324	S:S:V72	3.23	No	No	0	7	5
421	S:S:S323	S:S:V108	3.23	No	No	0	8	7
422	R:R:V71	R:R:V75	3.21	No	No	0	5	4
423	R:R:S324	R:R:T321	3.2	No	No	0	7	5
424	S:S:T321	S:S:V69	3.17	No	Yes	0	5	7
425	R:R:I208	R:R:S123	3.1	No	No	0	4	4
426	R:R:I191	R:R:S187	3.1	No	No	0	4	4
427	R:R:I328	R:R:V72	3.07	No	No	0	7	5
428	R:R:M121	R:R:S123	3.07	No	No	0	4	4
429	R:R:I243	R:R:V239	3.07	No	No	0	5	6
430	R:R:I242	R:R:V280	3.07	No	No	0	8	8
431	S:S:I328	S:S:V72	3.07	No	No	0	7	5
432	S:S:M121	S:S:S123	3.07	No	No	0	4	4
433	S:S:I243	S:S:V239	3.07	No	No	0	5	6
434	R:R:I241	R:R:T150	3.04	No	No	0	6	7
435	R:R:M151	R:R:V154	3.04	No	No	0	6	6
436	S:S:I292	S:S:T288	3.04	No	No	0	5	5
437	S:S:L74	S:S:S78	3	No	No	0	6	4
438	R:R:L130	R:R:V129	2.98	No	No	0	5	1
439	R:R:L329	R:R:V279	2.98	No	No	0	8	8
440	R:R:L329	R:R:V282	2.98	No	No	0	8	7
441	S:S:L240	S:S:V236	2.98	No	No	0	3	4
442	S:S:L248	S:S:V244	2.98	No	No	0	4	4
443	S:S:L329	S:S:V278	2.98	No	No	0	8	5
444	S:S:L329	S:S:V279	2.98	No	No	0	8	8
445	S:S:L329	S:S:V282	2.98	No	No	0	8	7
446	R:R:N326	R:R:V279	2.96	Yes	No	0	9	8
447	S:S:N122	S:S:V207	2.96	No	No	0	5	3
448	S:S:N326	S:S:V279	2.96	Yes	No	0	9	8
449	S:S:N322	S:S:V282	2.96	Yes	No	0	9	7
450	R:R:C161	R:R:H162	2.95	No	No	0	7	6
451	R:R:L325	R:R:T321	2.95	No	No	0	6	5
452	S:S:L74	S:S:T109	2.95	No	No	0	6	6
453	S:S:L248	S:S:T247	2.95	No	No	0	4	4
454	S:S:L325	S:S:T321	2.95	No	No	0	6	5
455	R:R:I58	R:R:I62	2.94	No	No	0	4	5
456	R:R:I133	R:R:I137	2.94	No	No	0	5	5
457	R:R:I232	R:R:I237	2.94	No	No	0	5	5
458	S:S:I58	S:S:I62	2.94	No	No	0	4	5
459	S:S:I232	S:S:I237	2.94	No	No	0	5	5
460	R:R:I96	R:R:K176	2.91	Yes	No	0	5	4
461	S:S:I96	S:S:K176	2.91	No	No	0	5	4
462	R:R:P56	S:S:F126	2.89	No	Yes	0	2	7
463	S:S:I177	S:S:L173	2.85	No	No	0	3	4
464	S:S:I180	S:S:L184	2.85	No	No	0	4	4
465	R:R:G127	R:R:W124	2.81	No	Yes	0	7	8
466	S:S:G127	S:S:W124	2.81	No	Yes	0	7	8
467	S:S:G319	S:S:W287	2.81	No	Yes	0	7	8
468	R:R:C345	R:R:F344	2.79	No	No	0	5	4
469	R:R:C345	R:R:F346	2.79	No	Yes	0	5	4
470	S:S:C229	S:S:F225	2.79	No	No	0	3	4
471	R:R:A64	S:S:F70	2.77	No	Yes	0	5	7
472	R:R:F70	S:S:A64	2.77	Yes	No	0	7	5
473	R:R:D128	R:R:K132	2.77	No	No	0	2	6
474	R:R:A331	R:R:F341	2.77	No	Yes	0	7	6
475	S:S:A166	S:S:R170	2.77	No	Yes	0	5	6
476	S:S:A331	S:S:F341	2.77	No	Yes	0	7	6
477	L:L:?1	R:R:L135	2.7	Yes	No	0	0	4
478	R:R:F293	R:R:S311	2.64	No	No	0	5	4
479	S:S:F293	S:S:S311	2.64	Yes	No	0	5	4
480	R:R:H162	R:R:K165	2.62	No	No	0	6	4
481	S:S:D204	S:S:E203	2.6	No	No	0	2	1
482	R:R:S136	R:R:Y140	2.54	No	Yes	0	5	5
483	S:S:S211	S:S:Y219	2.54	No	No	0	4	1
484	R:R:F82	R:R:I85	2.51	No	No	0	4	3
485	R:R:F332	R:R:I328	2.51	No	No	0	6	7
486	S:S:F169	S:S:I158	2.51	No	No	0	4	5
487	S:S:F233	S:S:I237	2.51	No	No	0	4	5
488	S:S:F332	S:S:I328	2.51	No	No	0	6	7
489	R:R:F346	S:S:K338	2.48	Yes	No	0	4	8
490	R:R:L269	R:R:R156	2.43	No	Yes	0	6	9
491	R:R:E203	R:R:R202	2.33	No	No	0	1	2
492	S:S:L224	S:S:W221	2.28	Yes	No	0	3	1
493	R:R:F231	R:R:F235	2.14	No	Yes	0	5	8
494	S:S:R263	S:S:R267	2.13	No	No	0	3	4
495	R:R:G197	R:R:G198	2.11	No	No	0	4	4
496	S:S:G197	S:S:G198	2.11	No	No	0	4	4
497	R:R:A193	R:R:G190	1.95	No	No	0	5	6
498	S:S:A193	S:S:G190	1.95	No	No	0	5	6
499	R:R:G76	R:R:V75	1.84	No	No	0	7	4
500	S:S:G76	S:S:V75	1.84	No	No	0	7	4
501	S:S:P163	S:S:V164	1.77	No	No	0	8	5
502	R:R:P59	S:S:T117	1.75	No	No	0	4	4
503	R:R:T117	S:S:P59	1.75	No	No	0	4	4
504	R:R:A57	R:R:S55	1.71	No	No	0	4	1
505	R:R:G319	R:R:L318	1.71	No	No	0	7	8
506	S:S:G300	S:S:L299	1.71	No	No	0	2	4
507	S:S:A308	S:S:S311	1.71	No	No	0	3	4
508	R:R:C181	R:R:I177	1.64	No	No	0	4	3
509	S:S:G198	S:S:Q213	1.64	No	No	0	4	4
510	R:R:A57	R:R:I61	1.62	No	No	0	4	5
511	R:R:S123	R:R:V207	1.62	No	No	0	4	3
512	R:R:S188	R:R:V189	1.62	No	Yes	0	4	5
513	R:R:S192	R:R:V189	1.62	No	Yes	0	7	5
514	S:S:S123	S:S:V207	1.62	No	No	0	4	3
515	S:S:S188	S:S:V189	1.62	No	No	0	4	5
516	S:S:S192	S:S:V189	1.62	No	No	0	7	5
517	R:R:A106	R:R:M81	1.61	No	Yes	0	8	7
518	R:R:D266	R:R:P163	1.61	No	No	0	3	8
519	R:R:A298	R:R:K227	1.61	No	Yes	0	4	4
520	S:S:A106	S:S:M81	1.61	No	No	0	8	7
521	R:R:V65	R:R:V69	1.6	No	No	0	5	7
522	R:R:V68	R:R:V72	1.6	No	No	0	5	5
523	R:R:V68	S:S:V71	1.6	No	No	0	5	5
524	R:R:V71	S:S:V68	1.6	No	No	0	5	5
525	R:R:V239	R:R:V284	1.6	No	No	0	6	6
526	S:S:V65	S:S:V69	1.6	No	Yes	0	5	7
527	S:S:V68	S:S:V72	1.6	No	No	0	5	5
528	S:S:V239	S:S:V284	1.6	No	No	0	6	6
529	R:R:A298	R:R:L224	1.58	No	No	0	4	3
530	S:S:A298	S:S:L224	1.58	No	Yes	0	4	3
531	R:R:T110	R:R:T111	1.57	No	Yes	0	4	7
532	S:S:T110	S:S:T111	1.57	No	Yes	0	4	7
533	S:S:I58	S:S:S55	1.55	No	No	0	4	1
534	R:R:I191	R:R:V195	1.54	No	No	0	4	4
535	R:R:I208	R:R:V201	1.54	No	No	0	4	2
536	S:S:I61	S:S:V65	1.54	No	No	0	5	5
537	S:S:I133	S:S:V129	1.54	No	No	0	5	1
538	S:S:I191	S:S:V195	1.54	No	No	0	4	4
539	S:S:I208	S:S:V201	1.54	No	No	0	4	2
540	R:R:M81	R:R:S78	1.53	Yes	No	0	7	4
541	S:S:H162	S:S:P163	1.53	Yes	No	0	6	8
542	R:R:I243	R:R:T247	1.52	No	No	0	5	4
543	R:R:K265	R:R:V256	1.52	No	No	0	4	6
544	R:R:I292	R:R:T288	1.52	No	No	0	5	5
545	R:R:K91	R:R:T88	1.5	No	No	0	7	6
546	R:R:L259	R:R:S255	1.5	No	No	0	3	4
547	R:R:L240	R:R:V236	1.49	No	No	0	3	4
548	R:R:L248	R:R:V244	1.49	No	No	0	4	4
549	S:S:L173	S:S:T171	1.47	No	No	0	4	7
550	R:R:I84	R:R:K91	1.45	No	No	0	7	7
551	R:R:I96	R:R:K91	1.45	Yes	No	0	5	7
552	R:R:F346	R:R:P347	1.44	Yes	No	0	4	4
553	R:R:I137	R:R:L107	1.43	No	No	0	5	6
554	R:R:I250	R:R:L251	1.43	No	No	0	5	4
555	S:S:I137	S:S:L107	1.43	No	No	0	5	6
556	S:S:I250	S:S:L251	1.43	No	No	0	5	4
557	R:R:L248	R:R:L251	1.38	No	No	0	4	4
558	S:S:L224	S:S:L299	1.38	Yes	No	0	3	4
559	R:R:K200	R:R:Q213	1.36	No	No	0	2	4
560	S:S:D168	S:S:L167	1.36	No	No	0	4	5
561	S:S:D266	S:S:L269	1.36	No	No	0	3	6
562	R:R:D204	R:R:E203	1.3	No	No	0	2	1
563	R:R:F147	R:R:L185	1.22	No	No	0	6	4
564	R:R:I158	R:R:Y157	1.21	No	Yes	0	5	7
565	R:R:N268	R:R:R267	1.21	No	No	0	5	4
566	R:R:D343	R:R:R339	1.19	No	No	0	3	5
567	S:S:D168	S:S:F169	1.19	No	No	0	4	4
568	S:S:E264	S:S:R267	1.16	No	No	0	3	4
569	S:S:D216	S:S:Y219	1.15	No	No	0	2	1
570	R:R:D218	R:R:W221	1.12	No	No	0	4	1
571	R:R:R257	R:R:R270	1.07	No	No	0	4	5
572	S:S:R257	S:S:R263	1.07	Yes	No	0	4	3
573	S:S:R339	S:S:R342	1.07	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.64667	12	2	0
2	M:M:?1	9.86833	12	1	0
3	R:R:F70	3.938	5	0	7
4	R:R:M81	3.09	4	0	7
5	R:R:I96	3.37	4	0	5
6	R:R:Y97	6.522	5	0	7
7	R:R:N100	9.602	5	4	9
8	R:R:T111	4.215	4	2	7
9	R:R:M112	7.902	5	0	7
10	R:R:W124	9.60167	6	2	8
11	R:R:F126	11.062	5	0	7
12	R:R:Y140	7.2475	4	0	5
13	R:R:T144	7.08	4	4	7
14	R:R:R156	6.68167	6	6	9
15	R:R:Y157	6.876	5	0	7
16	R:R:W183	9.795	4	4	9
17	R:R:V189	4.3675	4	0	5
18	R:R:F214	6.828	5	0	6
19	R:R:W222	8.56	4	7	7
20	R:R:K227	7.38	4	0	4
21	R:R:F235	7.4275	4	0	8
22	R:R:Y246	8.7825	4	0	8
23	R:R:R271	7.085	4	0	7
24	R:R:F283	9.378	5	2	9
25	R:R:W287	7.42375	8	2	8
26	R:R:I316	6.96	4	2	5
27	R:R:Y320	10.5725	4	2	6
28	R:R:N322	7.86	4	2	9
29	R:R:N326	6.8425	4	0	9
30	R:R:Y330	7.1775	4	0	9
31	R:R:D334	8.7025	4	0	8
32	R:R:F337	8.014	5	5	8
33	R:R:F341	6.235	4	0	6
34	R:R:F346	3.482	5	0	4
35	S:S:V69	3.9475	4	0	7
36	S:S:F70	4.234	5	0	7
37	S:S:Y97	6.4	6	3	7
38	S:S:D105	7.945	4	1	9
39	S:S:T111	4.455	4	1	7
40	S:S:M112	9.28	4	0	7
41	S:S:W124	9.49571	7	1	8
42	S:S:F126	10.6967	6	0	7
43	S:S:Y140	6.7225	4	0	5
44	S:S:F143	7.2375	4	0	6
45	S:S:T144	7.7275	4	0	7
46	S:S:R156	5.84667	6	3	9
47	S:S:Y157	7.2525	4	9	7
48	S:S:C161	5.3675	4	9	7
49	S:S:H162	6.94	4	9	6
50	S:S:R170	6.62	6	3	6
51	S:S:F214	6.198	5	0	6
52	S:S:L224	2.7375	4	0	3
53	S:S:K227	8.1825	4	0	4
54	S:S:F235	7.7225	4	0	8
55	S:S:Y246	10.5725	4	0	8
56	S:S:R257	7.5275	4	0	4
57	S:S:F283	10.162	5	1	9
58	S:S:W287	7.26667	6	1	8
59	S:S:F293	4.1625	4	0	5
60	S:S:N322	6.682	5	1	9
61	S:S:N326	6.026	5	1	9
62	S:S:Y330	7.005	4	0	9
63	S:S:F337	7.00333	6	8	8
64	S:S:F341	5.2	4	0	6
65	S:S:F346	6.545	4	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y320	63.5491	13.7	Yes	Yes	2	0	6
2	R:R:M112	R:R:Y320	72.8671	17.96	Yes	Yes	0	7	6
3	R:R:F70	R:R:M112	73.6342	4.98	Yes	Yes	0	7	7
4	R:R:F70	S:S:S67	90.5276	3.96	Yes	No	0	7	4
5	R:R:S67	S:S:S67	90.5849	6.52	No	No	0	4	4
6	R:R:S67	S:S:F70	90.689	3.96	No	Yes	0	4	7
7	S:S:F70	S:S:M112	91.6244	6.22	Yes	Yes	0	7	7
8	S:S:M112	S:S:Y320	100	17.96	Yes	No	0	7	6
9	M:M:?1	S:S:Y320	98.497	15.98	Yes	No	1	0	6
10	M:M:?1	S:S:Q115	12.6119	7.78	Yes	No	0	0	7
11	M:M:?1	S:S:Y139	11.9733	4.57	Yes	No	0	0	5
12	M:M:?1	S:S:C210	32.6293	4.12	Yes	No	1	0	9
13	M:M:?1	S:S:W287	99.4793	5.17	Yes	Yes	1	0	8
14	M:M:?1	S:S:I294	15.512	9.26	Yes	No	1	0	5
15	S:S:C210	S:S:W124	30.7654	20.89	No	Yes	1	9	8
16	S:S:F126	S:S:W124	19.6789	19.04	Yes	Yes	0	7	8
17	R:R:M112	R:R:V69	10.0677	4.56	Yes	No	0	7	7
18	R:R:F70	R:R:P113	19.6338	4.33	Yes	No	0	7	8
19	L:L:?1	R:R:W287	35.1423	5.91	Yes	Yes	2	0	8
20	R:R:N322	R:R:W287	11.6626	6.78	Yes	Yes	2	9	8
21	R:R:N322	R:R:N326	10.1284	9.54	Yes	Yes	0	9	9
22	L:L:?1	R:R:Y139	44.1184	6.09	Yes	No	0	0	5
23	R:R:V189	R:R:Y139	43.5699	5.05	Yes	No	0	5	5
24	R:R:F143	R:R:V189	42.0184	9.18	No	Yes	0	6	5
25	R:R:F143	R:R:F147	41.345	4.29	No	No	0	6	6
26	R:R:F147	R:R:I182	41.0187	7.54	No	No	0	6	7
27	R:R:I182	R:R:N100	40.3645	4.25	No	Yes	4	7	9
28	R:R:N100	R:R:N179	39.3648	20.43	Yes	No	0	9	7
29	R:R:I96	R:R:N179	25.0538	4.25	Yes	No	0	5	7
30	R:R:I96	R:R:K91	29.0299	1.45	Yes	No	0	5	7
31	R:R:I84	R:R:K91	29.0889	1.45	No	No	0	7	7
32	R:R:F337	R:R:I84	29.2225	3.77	Yes	No	0	8	7
33	R:R:F337	R:R:F341	48.9205	9.65	Yes	Yes	0	8	6
34	R:R:F341	R:R:L79	49.5974	6.09	Yes	No	0	6	6
35	R:R:F344	R:R:L79	49.6616	4.87	No	No	0	4	6
36	R:R:N100	R:R:W183	13.6047	10.17	Yes	Yes	4	9	9
37	R:R:N179	R:R:Y97	22.0774	4.65	No	Yes	0	7	7
38	R:R:M152	R:R:Y97	16.9681	5.99	No	Yes	0	8	7
39	R:R:M152	R:R:V276	16.0118	6.09	No	No	0	8	8
40	R:R:R156	R:R:V276	19.1513	6.54	Yes	No	0	9	8
41	R:R:I272	R:R:R156	19.2694	8.77	No	Yes	6	7	9
42	L:L:?1	R:R:C210	14.6911	4.12	Yes	No	2	0	9
43	R:R:C210	R:R:W124	12.9018	23.51	No	Yes	2	9	8
44	R:R:F126	R:R:W124	14.0403	15.03	Yes	Yes	0	7	8
45	R:R:F114	R:R:F126	18.4623	16.08	No	Yes	0	5	7
46	L:L:?1	R:R:I316	10.4651	4.63	Yes	Yes	2	0	5
47	R:R:I316	R:R:Y312	14.5869	13.3	Yes	No	0	5	4
48	S:S:I316	S:S:Q115	11.647	5.49	No	No	0	5	7
49	S:S:I316	S:S:Y312	10.6959	10.88	No	No	0	5	4
50	R:R:F126	R:R:P125	17.9365	13	Yes	No	0	7	1
51	R:R:M121	R:R:P125	17.0236	6.71	No	No	0	4	1
52	R:R:M121	R:R:S123	16.1073	3.07	No	No	0	4	4
53	L:L:?1	R:R:M142	12.185	11.01	Yes	No	2	0	7
54	R:R:H291	R:R:M142	11.3242	5.25	No	No	2	8	7
55	R:R:H291	R:R:W287	12.7907	4.23	No	Yes	2	8	8
56	R:R:V276	R:R:Y246	24.1843	3.79	No	Yes	0	8	8
57	R:R:M249	R:R:Y246	17.9035	3.59	No	Yes	0	8	8
58	R:R:M249	R:R:Y157	16.9924	3.59	No	Yes	0	8	7
59	R:R:R252	R:R:Y157	10.5172	18.52	No	Yes	0	5	7
60	L:L:?1	R:R:I294	18.8806	10.19	Yes	No	0	0	5
61	R:R:I294	R:R:K227	18.8667	7.27	No	Yes	0	5	4
62	R:R:D223	R:R:K227	13.7383	16.59	No	Yes	0	4	4
63	R:R:D223	R:R:Y219	12.7022	12.64	No	No	0	4	1
64	R:R:F214	R:R:Y219	10.6196	12.38	Yes	No	0	6	1
65	R:R:F235	R:R:H291	22.2822	15.84	Yes	No	0	8	8
66	R:R:D334	R:R:F337	25.9042	11.94	Yes	Yes	0	8	8
67	R:R:D334	R:R:R271	21.8431	10.72	Yes	Yes	0	8	7
68	R:R:I272	R:R:R271	19.9341	6.26	No	Yes	0	7	7
69	R:R:C345	R:R:F344	50.4391	2.79	No	No	0	5	4
70	R:R:C345	R:R:F346	50.6508	2.79	No	Yes	0	5	4
71	S:S:N322	S:S:W287	95.7133	4.52	Yes	Yes	1	9	8
72	S:S:N322	S:S:N326	95.0521	6.81	Yes	Yes	1	9	9
73	S:S:N326	S:S:Y330	96.4127	8.14	Yes	Yes	0	9	9
74	S:S:F337	S:S:Y330	64.8473	5.16	Yes	Yes	0	8	9
75	S:S:F337	S:S:F341	55.9372	6.43	Yes	Yes	0	8	6
76	R:R:F346	S:S:F341	53.1604	4.29	Yes	Yes	0	4	6
77	S:S:M112	S:S:V69	15.2464	4.56	Yes	Yes	0	7	7
78	S:S:S324	S:S:V69	10.7515	6.46	No	Yes	0	7	7
79	S:S:I98	S:S:Y330	75.8608	9.67	No	Yes	0	8	9
80	S:S:I98	S:S:M152	75.1701	4.37	No	No	0	8	8
81	S:S:M152	S:S:Y97	44.5609	7.18	No	Yes	0	8	7
82	S:S:M152	S:S:V276	32.6796	7.61	No	No	0	8	8
83	S:S:N179	S:S:Y97	27.3273	4.65	No	Yes	0	7	7
84	S:S:M151	S:S:Y97	13.8459	5.99	No	Yes	3	6	7
85	S:S:N100	S:S:N179	19.1583	20.43	No	No	0	9	7
86	S:S:N100	S:S:W183	14.4151	9.04	No	No	0	9	9
87	S:S:W183	S:S:Y140	10.7081	6.75	No	Yes	0	9	5
88	S:S:L212	S:S:Y139	10.9944	5.86	No	No	0	4	5
89	S:S:V276	S:S:Y246	23.5543	7.57	No	Yes	0	8	8
90	S:S:M151	S:S:V154	12.9816	4.56	No	No	0	6	6
91	S:S:M249	S:S:Y246	17.3343	10.78	No	Yes	0	8	8
92	S:S:M249	S:S:V160	16.4353	4.56	No	No	0	8	8
93	S:S:C245	S:S:V154	12.0739	3.42	No	No	0	7	6
94	S:S:C245	S:S:Y157	11.1871	4.03	No	Yes	0	7	7
95	S:S:F214	S:S:L212	10.0121	7.31	Yes	No	0	6	4
96	S:S:I294	S:S:K227	14.5939	7.27	No	Yes	0	5	4
97	S:S:H291	S:S:W287	11.0899	4.23	No	Yes	0	8	8
98	S:S:F235	S:S:H291	10.0989	13.58	Yes	No	0	8	8
99	R:R:F114	R:R:P113	18.7643	5.78	No	No	0	5	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
M:M:?1	S:S:T111	6.7	1	Yes	Yes	0	7	0	1
M:M:?1	S:S:Q115	7.78	1	Yes	No	0	7	0	1
M:M:?1	S:S:D138	37	1	Yes	No	0	6	0	1
M:M:?1	S:S:Y139	4.57	1	Yes	No	0	5	0	1
M:M:?1	S:S:M142	12.85	1	Yes	No	0	7	0	1
M:M:?1	S:S:C210	4.12	1	Yes	No	0	9	0	1
M:M:?1	S:S:V230	6.77	1	Yes	No	0	5	0	1
M:M:?1	S:S:W287	5.17	1	Yes	Yes	0	8	0	1
M:M:?1	S:S:I290	4.63	1	Yes	No	0	6	0	1
M:M:?1	S:S:I294	9.26	1	Yes	No	0	5	0	1
M:M:?1	S:S:Y320	15.98	1	Yes	No	0	6	0	1
S:S:I137	S:S:T111	4.56	0	No	Yes	5	7	2	1
S:S:T111	S:S:Y320	4.99	1	Yes	No	7	6	1	1
S:S:M112	S:S:Y320	17.96	0	Yes	No	7	6	2	1
S:S:I316	S:S:Q115	5.49	0	No	No	5	7	2	1
S:S:C131	S:S:W124	7.84	1	No	Yes	9	8	2	2
S:S:C210	S:S:W124	20.89	1	No	Yes	9	8	1	2
S:S:C131	S:S:C210	7.28	1	No	No	9	9	2	1
S:S:L212	S:S:Y139	5.86	0	No	No	4	5	2	1
S:S:F143	S:S:M142	4.98	0	Yes	No	6	7	2	1
S:S:M142	S:S:W287	5.82	1	No	Yes	7	8	1	1
S:S:F143	S:S:V230	6.55	0	Yes	No	6	5	2	1
S:S:I294	S:S:K227	7.27	1	No	Yes	5	4	1	2
S:S:F283	S:S:W287	21.05	1	Yes	Yes	9	8	2	1
S:S:F283	S:S:N322	9.67	1	Yes	Yes	9	9	2	2
S:S:H291	S:S:W287	4.23	0	No	Yes	8	8	2	1
S:S:N322	S:S:W287	4.52	1	Yes	Yes	9	8	2	1
S:S:I290	S:S:I294	4.42	1	No	No	6	5	1	1
M:M:?1	S:S:L135	3.59	1	Yes	No	0	4	0	1
S:S:G319	S:S:W287	2.81	0	No	Yes	7	8	2	1
S:S:T110	S:S:T111	1.57	0	No	Yes	4	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:T111	5.74	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:Q115	9.5	2	Yes	No	0	7	0	1
L:L:?1	R:R:D138	33.47	2	Yes	No	0	6	0	1
L:L:?1	R:R:Y139	6.09	2	Yes	No	0	5	0	1
L:L:?1	R:R:M142	11.01	2	Yes	No	0	7	0	1
L:L:?1	R:R:C210	4.12	2	Yes	No	0	9	0	1
L:L:?1	R:R:V230	8.7	2	Yes	No	0	5	0	1
L:L:?1	R:R:W287	5.91	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:I294	10.19	2	Yes	No	0	5	0	1
L:L:?1	R:R:I316	4.63	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y320	13.7	2	Yes	Yes	0	6	0	1
R:R:I137	R:R:T111	4.56	0	No	Yes	5	7	2	1
R:R:T111	R:R:Y320	4.99	2	Yes	Yes	7	6	1	1
R:R:M112	R:R:Y320	17.96	0	Yes	Yes	7	6	2	1
R:R:I316	R:R:Q115	5.49	2	Yes	No	5	7	1	1
R:R:Q115	R:R:Y320	5.64	2	No	Yes	7	6	1	1
R:R:C131	R:R:W124	5.22	2	No	Yes	9	8	2	2
R:R:C210	R:R:W124	23.51	2	No	Yes	9	8	1	2
R:R:C131	R:R:C210	7.28	2	No	No	9	9	2	1
R:R:V189	R:R:Y139	5.05	0	Yes	No	5	5	2	1
R:R:N141	R:R:W287	4.52	0	No	Yes	8	8	2	1
R:R:M142	R:R:W287	6.98	2	No	Yes	7	8	1	1
R:R:H291	R:R:M142	5.25	2	No	No	8	7	2	1
R:R:I294	R:R:K227	7.27	0	No	Yes	5	4	1	2
R:R:F283	R:R:W287	22.05	2	Yes	Yes	9	8	2	1
R:R:F283	R:R:N322	7.25	2	Yes	Yes	9	9	2	2
R:R:I290	R:R:W287	4.7	0	No	Yes	6	8	2	1
R:R:H291	R:R:W287	4.23	2	No	Yes	8	8	2	1
R:R:G319	R:R:W287	4.22	0	No	Yes	7	8	2	1
R:R:N322	R:R:W287	6.78	2	Yes	Yes	9	8	2	1
R:R:I290	R:R:I294	4.42	0	No	No	6	5	2	1
R:R:I290	R:R:I316	4.42	0	No	Yes	6	5	2	1
R:R:I316	R:R:Y312	13.3	2	Yes	No	5	4	1	2
L:L:?1	R:R:L135	2.7	2	Yes	No	0	4	0	1
R:R:T110	R:R:T111	1.57	0	No	Yes	4	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	4DJH_poly
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.96
Number of Linked Nodes	543
Number of Links	573
Number of Hubs	65
Number of Links mediated by Hubs	274
Number of Communities	9
Number of Nodes involved in Communities	57
Number of Links involved in Communities	72

Path Summary
Number Of Nodes in MetaPath	100
Number Of Links MetaPath	99
Number of Shortest Paths	162746
Length Of Smallest Path	3
Average Path Length	16.5131
Length of Longest Path	38
Minimum Path Strength	1.275
Average Path Strength	7.34927
Maximum Path Strength	26.49
Minimum Path Correlation	0.7
Average Path Correlation	0.962156
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	57.5616
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.4802
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• hydrolase activity, acting on glycosyl bonds • peptidoglycan muralytic activity • hydrolase activity, hydrolyzing O-glycosyl compounds • lysozyme activity • hydrolase activity • catalytic activity • binding • neuropeptide binding • peptide binding • peptide receptor activity • molecular transducer activity • G protein-coupled opioid receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled peptide receptor activity • dynorphin receptor activity • protein binding • receptor serine/threonine kinase binding • signaling receptor binding • defense response to bacterium • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • response to bacterium • response to stress • response to external stimulus • response to external biotic stimulus • response to biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process
Gene Ontology	Biological Process	• defense response to bacterium • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • response to bacterium • response to stress • response to external stimulus • response to external biotic stimulus • response to biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process • carbohydrate derivative metabolic process • aminoglycan catabolic process • macromolecule catabolic process • glycosaminoglycan catabolic process • aminoglycan metabolic process • peptidoglycan metabolic process • metabolic process • cellular process • macromolecule metabolic process • symbiont-mediated cytolysis of host cell • viral life cycle • disruption of cell in another organism • cytolysis • biological process involved in interaction with host • biological process involved in symbiotic interaction • viral release from host cell by cytolysis • exit from host cell • viral process • cytolysis in another organism • viral release from host cell • disruption of anatomical structure in another organism • symbiont-mediated killing of host cell • killing of cells of another organism • cell killing • cell wall organization or biogenesis • cell wall macromolecule catabolic process • cell wall macromolecule metabolic process • ovulation cycle • rhythmic process • estrous cycle • reproductive process • multicellular organismal reproductive process • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • cell communication • G protein-coupled opioid receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • multicellular organismal process • system process • sensory perception • nervous system process • phospholipase C-activating G protein-coupled receptor signaling pathway • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • behavior • learning • learning or memory • cognition • conditioned place preference • associative learning • defense response to virus • response to virus • response to acrylamide • response to chemical • response to oxygen-containing compound • response to nitrogen compound • neuropeptide signaling pathway • locomotory behavior • adult behavior • behavioral response to cocaine • response to cocaine • response to alkaloid • response to hormone • response to endogenous stimulus • response to estrogen • immune response • immune system process • homeostatic process • cellular response to glucose stimulus • intracellular glucose homeostasis • cellular response to oxygen-containing compound • response to hexose • cellular response to carbohydrate stimulus • cellular response to chemical stimulus • cellular homeostasis • response to monosaccharide • response to carbohydrate • chemical homeostasis • response to glucose • glucose homeostasis • carbohydrate homeostasis • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • maternal behavior • parental behavior • reproductive behavior • regulation of localization • negative regulation of luteinizing hormone secretion • regulation of system process • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • regulation of luteinizing hormone secretion • luteinizing hormone secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of biological quality • regulation of hormone levels • establishment of localization • regulation of secretion • endocrine hormone secretion • negative regulation of gonadotropin secretion • negative regulation of multicellular organismal process • regulation of endocrine process • regulation of hormone secretion • gonadotropin secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • secretion by cell • regulation of secretion by cell • signal release • negative regulation of cellular process • regulation of multicellular organismal process • regulation of signaling • secretion • regulation of transport • regulation of gonadotropin secretion • export from cell • endocrine process • hormone transport • regulation of cell communication • eating behavior • feeding behavior • sensory perception of temperature stimulus • response to lipid • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • cellular response to biotic stimulus • cellular response to lipid • response to molecule of bacterial origin • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting opioid receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • monoamine transport • nitrogen compound transport • regulation of catecholamine secretion • positive regulation of biological process • organic hydroxy compound transport • positive regulation of secretion by cell • dopamine transport • positive regulation of amine transport • catecholamine transport • positive regulation of secretion • positive regulation of cellular process • positive regulation of catecholamine secretion • dopamine secretion • positive regulation of dopamine secretion • catecholamine secretion • amine transport • positive regulation of transport • regulation of amine transport • regulation of dopamine secretion • regulation of body fluid levels • secretion by tissue • digestive system process • regulation of digestive system process • body fluid secretion • digestion • saliva secretion • regulation of saliva secretion • response to alcohol • response to ethanol • response to peptide hormone • response to insulin • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • p38MAPK cascade • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • positive regulation of p38MAPK cascade • regulation of response to stimulus • regulation of p38MAPK cascade • MAPK cascade • positive regulation of signaling • regulation of eating behavior • positive regulation of feeding behavior • positive regulation of eating behavior • regulation of behavior • positive regulation of behavior • positive regulation of multicellular organismal process • regulation of feeding behavior • sensory perception of pain • response to nicotine • positive regulation of cation transmembrane transport • regulation of potassium ion transport • monoatomic ion transmembrane transport • potassium ion transmembrane transport • regulation of monoatomic ion transmembrane transport • metal ion transport • monoatomic cation transmembrane transport • positive regulation of monoatomic ion transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation transport • regulation of metal ion transport • regulation of monoatomic ion transport • regulation of potassium ion transmembrane transport • transmembrane transport • positive regulation of potassium ion transport • regulation of transmembrane transport • positive regulation of potassium ion transmembrane transport • regulation of monoatomic cation transmembrane transport • potassium ion transport • host cellular component • host intracellular part • cellular anatomical structure • host cell cytoplasm • host cell part • host intracellular region • other organism part • cell periphery • postsynapse • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane
Gene Ontology	Cellular Component	• host cellular component • host intracellular part • cellular anatomical structure • host cell cytoplasm • host cell part • host intracellular region • other organism part • cell periphery • postsynapse • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • sarcolemma • T-tubule • somatodendritic compartment • cell body • perikaryon • neuronal cell body • intracellular anatomical structure • cytoplasm • cytosol • presynapse • presynaptic membrane • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • intracellular membrane-bounded organelle • endomembrane system • sarcoplasm • intracellular organelle • organelle • endoplasmic reticulum • sarcoplasmic reticulum • intracellular vesicle • transport vesicle membrane • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • synaptic vesicle • synaptic vesicle membrane • vesicle • transport vesicle • exocytic vesicle membrane • cytoplasmic vesicle membrane • secretory vesicle • organelle membrane • exocytic vesicle • mitochondrion • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • axon • axon terminus • distal axon • neuron projection terminus
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	JDC
PDB Residues	L:L:?1 M:M:?1
Environment Details	Open EMBL-EBI Page
Code	JDC
Name	(3R)-7-hydroxy-N-{(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
Synonyms
Identifier
Formula	C28 H39 N3 O3
Molecular Weight	465.628
SMILES
PubChem	9956146
Formal Charge	0
Total Atoms	73
Total Chiral Atoms	4
Total Bonds	76
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41145
Sequence	>4DJH_poly_Chain_R S P A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T K M K T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N S W P F G D V L C K I V L S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H P V K A L D F R T P L K A K I I N I C I W L L S S S V G I S A I V L G G T K V R E D V D V I E C S L Q F P D D D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V R L L S G R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F K R C F R D F C F P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6B73	A	Peptide	Opioid	κ	Homo sapiens	MP1104	-	-	3.1	2018-01-17	doi.org/10.1016/j.cell.2017.12.011
	8F7W	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.19	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7W (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.19	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	4DJH	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	2.9	2012-03-21	doi.org/10.1038/nature10939
	6VI4	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	3.3	2020-03-18	doi.org/10.1038/s41467-020-14889-7
	7YIT	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-	-	3.3	2023-04-12	doi.org/10.1038/s41467-023-37041-7
	8FEG	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-	Gi1/β1/γ2	2.54	2023-12-06	doi.org/10.1038/s41467-023-43718-w
	8FEG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-		2.54	2023-12-06	doi.org/10.1038/s41467-023-43718-w
	8DZP	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Gi1/β1/γ2	2.71	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZP (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.71	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZQ	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Go/β1/γ2	2.82	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZQ (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.82	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZR	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gt3)/β1/γ2	2.61	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZR (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.61	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZS	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gz)/β1/γ2	2.65	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZS (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.65	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	7Y1F	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.3	2023-05-24	doi.org/10.1093/procel/pwac033
	7Y1F (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.3	2023-05-24	doi.org/10.1093/procel/pwac033
	9MQK	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	3.18	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQL	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	2.96	2025-02-12	doi.org/10.1101/2025.01.09.632033
	8VVE	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVE (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG	A	Peptide	Opioid	κ	Homo sapiens	GB18	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GB18	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9D61	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9D61 (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0

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Download 4DJH_poly.zip

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