psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F196	R:R:R193	8.55	No	No	0	6	5
2	R:R:A481	R:R:R193	2.77	No	No	0	5	5
3	R:R:F196	R:R:P221	5.78	No	No	0	6	7
4	R:R:F196	R:R:S226	6.61	No	No	0	6	4
5	R:R:I199	R:R:V197	3.07	No	No	0	4	5
6	R:R:I199	R:R:N217	4.25	No	No	0	4	5
7	R:R:E202	R:R:Y207	4.49	No	Yes	0	4	5
8	R:R:H204	R:R:N208	11.48	No	No	0	4	5
9	R:R:L206	R:R:P205	3.28	No	No	0	3	3
10	R:R:P205	R:R:Y207	6.95	No	Yes	0	3	5
11	R:R:L206	R:R:V210	4.47	No	No	0	3	6
12	R:R:L206	R:R:Y307	4.69	No	Yes	0	3	6
13	R:R:H302	R:R:Y207	11.98	No	Yes	0	3	5
14	R:R:K209	R:R:N208	16.79	No	No	0	5	5
15	R:R:T212	R:R:V210	4.76	No	No	0	5	6
16	R:R:A219	R:R:T212	5.03	No	No	0	7	5
17	R:R:E479	R:R:G213	3.27	No	Yes	0	6	4
18	R:R:P216	R:R:V215	3.53	No	No	0	2	5
19	R:R:C218	R:R:V215	5.12	No	No	0	9	5
20	R:R:P221	R:R:V220	3.53	No	No	0	7	5
21	R:R:P221	R:R:P225	3.9	No	No	0	7	6
22	R:R:C222	R:R:H293	2.95	No	Yes	0	9	6
23	R:R:C222	R:R:C298	7.28	No	No	0	9	9
24	R:R:R232	R:R:Y223	11.32	No	No	0	6	4
25	R:R:H293	R:R:Y223	5.44	Yes	No	0	6	4
26	R:R:P225	R:R:Q224	3.16	No	No	0	6	5
27	R:R:F227	R:R:Q224	3.51	No	No	0	8	5
28	R:R:P385	R:R:Q224	4.74	No	No	0	7	5
29	R:R:F227	R:R:W478	17.04	No	No	0	8	9
30	R:R:E499	R:R:F227	3.5	No	No	0	5	8
31	R:R:E231	R:R:S228	2.87	No	No	7	7	4
32	R:R:S228	R:R:Y500	6.36	No	Yes	7	4	6
33	R:R:A229	R:R:D230	3.09	No	No	0	3	3
34	R:R:E231	R:R:Y500	14.59	No	Yes	7	7	6
35	R:R:F234	R:R:W238	9.02	No	No	0	7	9
36	R:R:F234	R:R:Y500	6.19	No	Yes	0	7	6
37	R:R:A235	R:R:Y500	2.67	No	Yes	0	6	6
38	R:R:W238	R:R:W242	13.12	No	No	0	9	8
39	R:R:M504	R:R:W238	5.82	No	No	0	8	9
40	R:R:F508	R:R:W242	22.05	No	No	0	8	8
41	R:R:F285	R:R:S243	2.64	No	No	0	7	8
42	R:R:L286	R:R:S243	3	No	No	0	5	8
43	R:R:I515	R:R:L245	4.28	No	No	0	8	6
44	R:R:C246	R:R:L511	6.35	No	No	0	9	8
45	R:R:C246	R:R:I515	3.27	No	No	0	9	8
46	R:R:F247	R:R:I248	3.77	Yes	No	8	6	3
47	R:R:F247	R:R:S251	10.57	Yes	No	8	6	6
48	R:R:F247	R:R:S282	3.96	Yes	No	0	6	8
49	R:R:F247	R:R:L286	3.65	Yes	No	0	6	5
50	R:R:I248	R:R:S251	4.64	No	No	8	3	6
51	R:R:I515	R:R:S249	6.19	No	No	0	8	8
52	R:R:T250	R:R:T253	3.14	No	No	9	8	9
53	R:R:L279	R:R:T250	7.37	No	No	0	6	8
54	R:R:S517	R:R:T250	3.2	No	No	9	9	8
55	R:R:T252	R:R:T256	3.14	No	No	0	6	9
56	R:R:T252	R:R:W530	3.64	No	Yes	0	6	9
57	R:R:S517	R:R:T253	3.2	No	No	9	9	9
58	R:R:I521	R:R:T253	6.08	No	No	0	7	9
59	R:R:F257	R:R:L258	3.65	No	No	0	9	7
60	R:R:F257	R:R:F264	6.43	No	No	1	9	9
61	R:R:F257	R:R:I272	16.33	No	Yes	1	9	7
62	R:R:I259	R:R:W530	10.57	No	Yes	0	8	9
63	R:R:F533	R:R:I259	3.77	No	No	0	6	8
64	R:R:D260	R:R:R263	15.48	No	No	0	8	9
65	R:R:D260	R:R:T526	4.34	No	No	0	8	9
66	R:R:E262	R:R:R265	23.26	No	No	1	4	6
67	R:R:E262	R:R:R269	11.63	No	Yes	1	4	9
68	R:R:F264	R:R:R263	7.48	No	No	0	9	9
69	R:R:F264	R:R:I272	5.02	No	Yes	1	9	7
70	R:R:R265	R:R:Y266	4.12	No	Yes	0	6	9
71	R:R:R265	R:R:R269	3.2	No	Yes	1	6	9
72	R:R:I353	R:R:Y266	3.63	Yes	Yes	0	9	9
73	R:R:A354	R:R:Y266	9.34	No	Yes	0	7	9
74	R:R:E268	R:R:P267	12.58	No	No	0	9	9
75	R:R:N350	R:R:P267	4.89	No	No	10	7	9
76	R:R:I353	R:R:P267	5.08	Yes	No	10	9	9
77	R:R:E268	R:R:I450	4.1	No	Yes	0	9	8
78	R:R:P270	R:R:R269	2.88	No	Yes	0	9	9
79	R:R:F273	R:R:R269	3.21	No	Yes	0	7	9
80	R:R:P270	R:R:W332	2.7	No	Yes	0	9	9
81	R:R:L336	R:R:P270	9.85	No	No	0	9	9
82	R:R:I271	R:R:L336	2.85	No	No	0	9	9
83	R:R:F453	R:R:I271	5.02	No	No	2	9	9
84	R:R:I271	R:R:W520	3.52	No	Yes	2	9	9
85	R:R:F273	R:R:W332	24.05	No	Yes	0	7	9
86	R:R:L274	R:R:Y278	3.52	No	Yes	0	8	9
87	R:R:S275	R:R:S517	6.52	No	No	0	8	9
88	R:R:C277	R:R:F325	4.19	No	No	0	9	9
89	R:R:C277	R:R:S329	3.44	No	No	0	9	8
90	R:R:S329	R:R:Y278	6.36	No	Yes	0	8	9
91	R:R:Y278	R:R:Y457	2.98	Yes	Yes	11	9	9
92	R:R:V513	R:R:Y278	11.36	No	Yes	11	8	9
93	R:R:G514	R:R:Y278	4.35	No	Yes	0	9	9
94	R:R:C280	R:R:F325	18.15	No	No	0	6	9
95	R:R:L283	R:R:L286	2.77	No	No	0	4	5
96	R:R:L283	R:R:L321	4.15	No	No	0	4	6
97	R:R:F285	R:R:I389	3.77	No	Yes	0	7	7
98	R:R:V287	R:R:V318	3.21	No	No	12	5	9
99	R:R:L289	R:R:R288	3.64	No	Yes	0	5	9
100	R:R:H293	R:R:R288	4.51	Yes	Yes	6	6	9
101	R:R:G388	R:R:R288	3	No	Yes	6	9	9
102	R:R:G388	R:R:H293	9.53	No	Yes	6	9	6
103	R:R:R300	R:R:S295	2.64	No	No	0	3	4
104	R:R:L314	R:R:V296	4.47	No	No	0	4	6
105	R:R:H304	R:R:S299	4.18	No	No	0	4	4
106	R:R:H302	R:R:H304	3.58	No	No	0	3	4
107	R:R:I305	R:R:Y307	6.04	No	Yes	0	5	6
108	R:R:H306	R:R:T310	4.11	No	Yes	0	7	6
109	R:R:D382	R:R:Y307	3.45	Yes	Yes	5	8	6
110	R:R:Q395	R:R:Y307	22.55	Yes	Yes	5	6	6
111	R:R:E308	R:R:S379	11.5	No	No	0	7	6
112	R:R:E308	R:R:Q395	6.37	No	Yes	0	7	6
113	R:R:L376	R:R:T309	5.9	No	No	0	8	6
114	R:R:S379	R:R:T309	3.2	No	No	0	6	6
115	R:R:G311	R:R:T310	3.64	No	Yes	0	6	6
116	R:R:G311	R:R:P312	4.06	No	No	0	6	7
117	R:R:C315	R:R:C390	7.28	No	No	0	9	9
118	R:R:F319	R:R:Y323	7.22	Yes	Yes	0	9	9
119	R:R:F319	R:R:V381	7.87	Yes	No	0	9	8
120	R:R:C390	R:R:F319	2.79	No	Yes	0	9	9
121	R:R:F319	R:R:V392	2.62	Yes	No	0	9	9
122	R:R:M327	R:R:Y323	11.97	Yes	Yes	0	9	9
123	R:R:Y323	R:R:Y391	6.95	Yes	Yes	0	9	5
124	R:R:F403	R:R:Y323	5.16	Yes	Yes	0	8	9
125	R:R:F324	R:R:F325	9.65	Yes	No	0	8	9
126	R:R:F324	R:R:P368	4.33	Yes	No	0	8	9
127	R:R:F324	R:R:S369	5.28	Yes	No	0	8	7
128	R:R:G326	R:R:S329	3.71	No	No	0	7	8
129	R:R:K371	R:R:M327	2.88	No	Yes	0	7	9
130	R:R:M327	R:R:P407	5.03	Yes	No	13	9	9
131	R:R:M327	R:R:Y411	3.59	Yes	Yes	13	9	8
132	R:R:A328	R:R:W365	2.59	No	No	0	9	9
133	R:R:A328	R:R:P368	3.74	No	No	0	9	9
134	R:R:S330	R:R:Y411	3.82	No	Yes	0	8	8
135	R:R:S330	R:R:Y457	2.54	No	Yes	0	8	9
136	R:R:I331	R:R:Y411	10.88	No	Yes	0	6	8
137	R:R:I335	R:R:W332	4.7	No	Yes	0	6	9
138	R:R:W332	R:R:W365	12.18	Yes	No	0	9	9
139	R:R:G415	R:R:W333	2.81	No	No	0	9	9
140	R:R:W333	R:R:Y457	27.01	No	Yes	0	9	9
141	R:R:G415	R:R:S337	3.71	No	No	0	9	8
142	R:R:F418	R:R:L338	6.09	No	No	0	8	5
143	R:R:A344	R:R:W340	7.78	No	Yes	0	9	9
144	R:R:L419	R:R:W340	3.42	Yes	Yes	3	8	9
145	R:R:G422	R:R:W340	4.22	No	Yes	0	9	9
146	R:R:F423	R:R:W340	8.02	No	Yes	3	7	9
147	R:R:M447	R:R:W340	4.65	Yes	Yes	0	9	9
148	R:R:F341	R:R:M346	7.46	Yes	No	0	8	7
149	R:R:F341	R:R:F418	7.5	Yes	No	0	8	8
150	R:R:A421	R:R:F341	5.55	No	Yes	0	6	8
151	R:R:F341	R:R:G422	3.01	Yes	No	0	8	9
152	R:R:L342	R:R:W348	7.97	No	Yes	0	9	9
153	R:R:G345	R:R:M346	3.49	No	No	0	6	7
154	R:R:G345	R:R:S425	3.71	No	No	0	6	9
155	R:R:M346	R:R:W348	13.96	No	Yes	0	7	9
156	R:R:W348	R:R:Y356	3.86	Yes	No	0	9	6
157	R:R:I353	R:R:N350	2.83	Yes	No	10	9	7
158	R:R:F360	R:R:Y356	5.16	No	No	0	8	6
159	R:R:H361	R:R:L362	2.57	No	No	0	9	6
160	R:R:I367	R:R:P368	3.39	No	No	0	5	9
161	R:R:K371	R:R:T374	3	No	No	0	7	5
162	R:R:I373	R:R:L376	2.85	No	No	0	7	8
163	R:R:A375	R:R:F403	5.55	No	Yes	0	6	8
164	R:R:L378	R:R:S380	3	No	No	0	6	6
165	R:R:S380	R:R:S399	6.52	No	No	14	6	7
166	R:R:F403	R:R:S380	3.96	Yes	No	14	8	6
167	R:R:D382	R:R:N394	5.39	Yes	No	0	8	7
168	R:R:D382	R:R:Q395	7.83	Yes	Yes	5	8	6
169	R:R:D384	R:R:P385	3.22	No	No	0	9	7
170	R:R:D384	R:R:I389	4.2	No	Yes	0	9	7
171	R:R:D384	R:R:N394	5.39	No	No	0	9	7
172	R:R:L503	R:R:V386	5.96	No	No	0	7	8
173	R:R:A387	R:R:I389	6.5	No	Yes	0	8	7
174	R:R:A387	R:R:Y507	4	No	No	0	8	8
175	R:R:I389	R:R:Y391	3.63	Yes	Yes	0	7	5
176	R:R:V392	R:R:Y391	3.79	No	Yes	0	9	5
177	R:R:V404	R:R:Y391	3.79	No	Yes	0	8	5
178	R:R:F403	R:R:V392	9.18	Yes	No	0	8	9
179	R:R:G393	R:R:L400	3.42	No	Yes	0	8	8
180	R:R:N396	R:R:Q395	2.64	No	Yes	0	7	6
181	R:R:N396	R:R:N398	2.72	No	No	0	7	3
182	R:R:N396	R:R:S399	8.94	No	No	0	7	7
183	R:R:L397	R:R:Q472	3.99	No	Yes	4	4	5
184	R:R:L397	R:R:R475	3.64	No	No	0	4	6
185	R:R:E476	R:R:L397	2.65	No	No	4	4	4
186	R:R:F403	R:R:S399	2.64	Yes	No	14	8	7
187	R:R:L400	R:R:V404	2.98	Yes	No	0	8	8
188	R:R:L400	R:R:L405	11.07	Yes	No	0	8	7
189	R:R:L405	R:R:R401	3.64	No	No	0	7	5
190	R:R:G406	R:R:P407	4.06	No	No	0	5	9
191	R:R:P407	R:R:Y411	8.34	No	Yes	13	9	8
192	R:R:L413	R:R:V409	2.98	No	No	0	4	4
193	R:R:L410	R:R:Y411	5.86	No	Yes	0	4	8
194	R:R:L412	R:R:S462	6.01	No	No	0	8	5
195	R:R:F423	R:R:L419	4.87	No	Yes	3	7	8
196	R:R:L419	R:R:T454	7.37	Yes	No	3	8	8
197	R:R:L419	R:R:L455	5.54	Yes	No	3	8	7
198	R:R:G422	R:R:S425	3.71	No	No	0	9	9
199	R:R:F423	R:R:L455	3.65	No	No	3	7	7
200	R:R:L426	R:R:L443	2.77	No	No	0	8	8
201	R:R:I448	R:R:L426	2.85	No	No	0	7	8
202	R:R:L443	R:R:M447	2.83	No	Yes	0	8	9
203	R:R:E444	R:R:K445	9.45	No	No	0	9	7
204	R:R:I450	R:R:M447	4.37	Yes	Yes	0	8	9
205	R:R:I450	R:R:R449	3.76	Yes	No	2	8	9
206	R:R:R449	R:R:W520	10	No	Yes	2	9	9
207	R:R:I450	R:R:W520	3.52	Yes	Yes	2	8	9
208	R:R:G451	R:R:T454	3.64	No	No	0	8	8
209	R:R:F453	R:R:T516	7.78	No	No	0	9	8
210	R:R:F453	R:R:W520	7.02	No	Yes	2	9	9
211	R:R:L455	R:R:T454	4.42	No	No	3	7	8
212	R:R:V513	R:R:Y457	7.57	No	Yes	11	8	9
213	R:R:P460	R:R:V459	3.53	No	No	0	8	8
214	R:R:I463	R:R:M509	5.83	No	Yes	0	5	8
215	R:R:M509	R:R:V464	4.56	Yes	No	0	8	7
216	R:R:C467	R:R:K506	8.08	No	Yes	0	8	9
217	R:R:C467	R:R:M509	3.24	No	Yes	0	8	8
218	R:R:K506	R:R:Y468	15.53	Yes	No	0	9	4
219	R:R:L469	R:R:Q472	3.99	No	Yes	0	5	5
220	R:R:E471	R:R:K506	4.05	No	Yes	0	9	9
221	R:R:H473	R:R:Q472	3.71	No	Yes	4	4	5
222	R:R:E476	R:R:Q472	8.92	No	Yes	4	4	5
223	R:R:E476	R:R:H473	3.69	No	No	4	4	4
224	R:R:W478	R:R:Y474	12.54	No	No	0	9	4
225	R:R:E499	R:R:Y474	12.35	No	No	0	5	4
226	R:R:S477	R:R:W478	12.36	No	No	0	2	9
227	R:R:E499	R:R:V502	4.28	No	No	0	5	6
228	R:R:M504	R:R:Y500	7.18	No	Yes	0	8	6
229	R:R:V502	R:R:W501	7.36	No	No	0	6	6
230	R:R:L503	R:R:Y507	3.52	No	No	0	7	8
231	R:R:L505	R:R:M509	9.9	No	Yes	0	7	8
232	R:R:K506	R:R:Y507	4.78	Yes	No	0	9	8
233	R:R:F508	R:R:V512	6.55	No	No	0	8	7
234	R:R:I521	R:R:W520	3.52	No	Yes	0	7	9
235	R:R:E528	R:R:R531	16.28	No	No	15	4	5
236	R:R:E528	R:R:R532	10.47	No	No	15	4	4
237	R:R:T534	R:R:W530	6.06	No	Yes	0	4	9
238	R:R:R531	R:R:R532	4.26	No	No	15	5	4
239	R:R:R532	R:R:S535	5.27	No	No	0	4	4
240	R:R:F533	R:R:R536	10.69	No	No	0	6	7
241	R:R:V322	R:R:Y391	2.52	No	Yes	0	5	5
242	R:R:F285	R:R:I239	2.51	No	No	0	7	6
243	R:R:I272	R:R:R269	2.51	Yes	Yes	1	7	9
244	R:R:V334	R:R:W333	2.45	No	No	0	8	9
245	R:R:F427	R:R:L426	2.44	No	No	0	6	8
246	R:R:F508	R:R:L505	2.44	No	No	0	8	7
247	R:R:L400	R:R:R475	2.43	Yes	No	0	8	6
248	R:R:K201	R:R:Y207	2.39	No	Yes	0	3	5
249	R:R:L245	R:R:W242	2.28	No	No	0	6	8
250	R:R:H361	R:R:W332	2.12	No	Yes	0	9	9
251	R:R:A297	R:R:G383	1.95	No	No	0	8	8
252	R:R:A354	R:R:G355	1.95	No	No	0	7	5
253	R:R:A387	R:R:G388	1.95	No	No	0	8	9
254	R:R:C218	R:R:P198	1.88	No	No	0	9	4
255	R:R:G240	R:R:S243	1.86	No	No	0	4	8
256	R:R:G518	R:R:S249	1.86	No	No	0	7	8
257	R:R:G213	R:R:V215	1.84	Yes	No	0	4	5
258	R:R:G326	R:R:V281	1.84	No	No	0	7	8
259	R:R:G284	R:R:V287	1.84	No	No	12	7	5
260	R:R:G284	R:R:V318	1.84	No	No	12	7	9
261	R:R:G292	R:R:V291	1.84	No	No	0	8	5
262	R:R:G518	R:R:V519	1.84	No	No	0	7	7
263	R:R:G524	R:R:V527	1.84	No	No	0	5	4
264	R:R:G345	R:R:K347	1.74	No	No	0	6	9
265	R:R:G213	R:R:L482	1.71	Yes	No	0	4	6
266	R:R:G284	R:R:L321	1.71	No	No	0	7	6
267	R:R:C390	R:R:V318	1.71	No	No	0	9	9
268	R:R:A219	R:R:V197	1.7	No	No	0	7	5
269	R:R:A297	R:R:V296	1.7	No	No	0	8	6
270	R:R:C315	R:R:T310	1.69	No	Yes	0	9	6
271	R:R:A313	R:R:T316	1.68	No	Yes	0	6	8
272	R:R:D382	R:R:G383	1.68	Yes	No	0	8	8
273	R:R:G213	R:R:Q214	1.64	Yes	No	0	4	4
274	R:R:G355	R:R:Q358	1.64	No	No	0	5	7
275	R:R:S295	R:R:V291	1.62	No	No	0	4	5
276	R:R:A364	R:R:I331	1.62	No	No	0	9	6
277	R:R:A364	R:R:I335	1.62	No	No	0	9	6
278	R:R:S251	R:R:T252	1.6	No	No	0	6	6
279	R:R:V290	R:R:V291	1.6	No	No	0	3	5
280	R:R:V334	R:R:V414	1.6	No	No	0	8	5
281	R:R:V409	R:R:V465	1.6	No	No	0	4	7
282	R:R:S523	R:R:T526	1.6	No	No	0	9	9
283	R:R:S529	R:R:T526	1.6	No	No	0	8	9
284	R:R:T458	R:R:V459	1.59	No	No	0	7	8
285	R:R:A461	R:R:L412	1.58	No	No	0	8	8
286	R:R:E194	R:R:P195	1.57	No	No	0	2	5
287	R:R:T309	R:R:T316	1.57	No	Yes	0	6	8
288	R:R:T310	R:R:T316	1.57	Yes	Yes	0	6	8
289	R:R:T416	R:R:T458	1.57	No	No	0	6	7
290	R:R:I373	R:R:S372	1.55	No	No	0	7	8
291	R:R:I272	R:R:V254	1.54	Yes	No	0	7	7
292	R:R:I463	R:R:V459	1.54	No	No	0	5	8
293	R:R:K525	R:R:S523	1.53	No	No	0	9	9
294	R:R:I317	R:R:T316	1.52	No	Yes	0	5	8
295	R:R:I353	R:R:T339	1.52	Yes	No	0	9	8
296	R:R:G292	R:R:R288	1.5	No	Yes	0	8	9
297	R:R:G402	R:R:R401	1.5	No	No	0	4	5
298	R:R:L408	R:R:V404	1.49	No	No	0	8	8
299	R:R:L469	R:R:V465	1.49	No	No	0	5	7
300	R:R:L412	R:R:T416	1.47	No	No	0	8	6
301	R:R:I448	R:R:I452	1.47	No	No	0	7	5
302	R:R:L482	R:R:T483	1.47	No	No	0	6	5
303	R:R:E479	R:R:T212	1.41	No	No	0	6	5
304	R:R:K445	R:R:L446	1.41	No	No	0	7	8
305	R:R:L446	R:R:M447	1.41	No	Yes	0	8	9
306	R:R:K201	R:R:N208	1.4	No	No	0	3	5
307	R:R:H204	R:R:S203	1.39	No	No	0	4	4
308	R:R:A363	R:R:F360	1.39	No	No	0	7	8
309	R:R:L419	R:R:L420	1.38	Yes	No	0	8	6
310	R:R:A294	R:R:Y223	1.33	No	No	0	5	4
311	R:R:A357	R:R:Y266	1.33	No	Yes	0	8	9
312	R:R:E351	R:R:N350	1.31	No	No	0	9	7
313	R:R:A352	R:R:W348	1.3	No	Yes	0	9	9
314	R:R:V527	R:R:W530	1.23	No	Yes	0	4	9
315	R:R:F324	R:R:L320	1.22	Yes	No	0	8	8
316	R:R:D230	R:R:R232	1.19	No	No	0	3	6
317	R:R:Q214	R:R:R211	1.17	No	No	0	4	2
318	R:R:F360	R:R:Y359	1.03	No	No	0	8	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y207	6.4525	4	0	5
2	R:R:G213	2.115	4	0	4
3	R:R:F247	5.4875	4	8	6
4	R:R:Y266	4.605	4	0	9
5	R:R:R269	4.686	5	1	9
6	R:R:I272	6.35	4	1	7
7	R:R:Y278	5.714	5	11	9
8	R:R:R288	3.1625	4	6	9
9	R:R:H293	5.6075	4	6	6
10	R:R:Y307	9.1825	4	5	6
11	R:R:T310	2.7525	4	0	6
12	R:R:T316	1.585	4	0	8
13	R:R:F319	5.125	4	0	9
14	R:R:Y323	7.825	4	0	9
15	R:R:F324	5.12	4	0	8
16	R:R:M327	5.8675	4	13	9
17	R:R:W332	9.15	5	0	9
18	R:R:W340	5.618	5	3	9
19	R:R:F341	5.88	4	0	8
20	R:R:W348	6.7725	4	0	9
21	R:R:I353	3.265	4	10	9
22	R:R:D382	4.5875	4	5	8
23	R:R:I389	4.525	4	0	7
24	R:R:Y391	4.136	5	0	5
25	R:R:Q395	9.8475	4	5	6
26	R:R:L400	4.975	4	0	8
27	R:R:F403	5.298	5	14	8
28	R:R:Y411	6.498	5	13	8
29	R:R:L419	4.516	5	3	8
30	R:R:M447	3.315	4	0	9
31	R:R:I450	3.9375	4	2	8
32	R:R:Y457	10.025	4	11	9
33	R:R:Q472	5.1525	4	4	5
34	R:R:Y500	7.398	5	7	6
35	R:R:K506	8.11	4	0	9
36	R:R:M509	5.8825	4	0	8
37	R:R:W520	5.516	5	2	9
38	R:R:W530	5.375	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P385	R:R:Q224	19.9929	4.74	No	No	0	7	5
2	R:R:D384	R:R:P385	21.1801	3.22	No	No	0	9	7
3	R:R:D384	R:R:N394	23.4002	5.39	No	No	0	9	7
4	R:R:D382	R:R:N394	22.5533	5.39	Yes	No	0	8	7
5	R:R:D382	R:R:Y307	14.1992	3.45	Yes	Yes	5	8	6
6	R:R:L206	R:R:Y307	32.2569	4.69	No	Yes	0	3	6
7	R:R:L206	R:R:V210	19.2331	4.47	No	No	0	3	6
8	R:R:T212	R:R:V210	18.0854	4.76	No	No	0	5	6
9	R:R:P205	R:R:Y207	12.2363	6.95	No	Yes	0	3	5
10	R:R:L206	R:R:P205	13.4236	3.28	No	No	0	3	3
11	R:R:E479	R:R:T212	12.2284	1.41	No	No	0	6	5
12	R:R:E479	R:R:G213	11.0333	3.27	No	Yes	0	6	4
13	R:R:G388	R:R:H293	10.1864	9.53	No	Yes	6	9	6
14	R:R:A387	R:R:G388	20.3807	1.95	No	No	0	8	9
15	R:R:A387	R:R:I389	62.6459	6.5	No	Yes	0	8	7
16	R:R:D384	R:R:I389	38.7985	4.2	No	Yes	0	9	7
17	R:R:F227	R:R:Q224	10.2101	3.51	No	No	0	8	5
18	R:R:W238	R:R:W242	14.2744	13.12	No	No	0	9	8
19	R:R:F508	R:R:W242	24.0571	22.05	No	No	0	8	8
20	R:R:F508	R:R:L505	26.4237	2.44	No	No	0	8	7
21	R:R:L505	R:R:M509	27.5951	9.9	No	Yes	0	7	8
22	R:R:C467	R:R:M509	38.8737	3.24	No	Yes	0	8	8
23	R:R:C467	R:R:K506	39.958	8.08	No	Yes	0	8	9
24	R:R:K506	R:R:Y507	43.1636	4.78	Yes	No	0	9	8
25	R:R:A387	R:R:Y507	46.2978	4	No	No	0	8	8
26	R:R:F285	R:R:I389	22.8106	3.77	No	Yes	0	7	7
27	R:R:F285	R:R:S243	20.4915	2.64	No	No	0	7	8
28	R:R:L286	R:R:S243	18.2279	3	No	No	0	5	8
29	R:R:F247	R:R:L286	16.0275	3.65	Yes	No	0	6	5
30	R:R:F247	R:R:S251	12.3669	10.57	Yes	No	8	6	6
31	R:R:I389	R:R:Y391	77.7395	3.63	Yes	Yes	0	7	5
32	R:R:Y323	R:R:Y391	73.331	6.95	Yes	Yes	0	9	5
33	R:R:M327	R:R:Y323	100	11.97	Yes	Yes	0	9	9
34	R:R:M327	R:R:Y411	97.8234	3.59	Yes	Yes	13	9	8
35	R:R:I331	R:R:Y411	87.5183	10.88	No	Yes	0	6	8
36	R:R:A364	R:R:I331	87.1146	1.62	No	No	0	9	6
37	R:R:A364	R:R:I335	86.7189	1.62	No	No	0	9	6
38	R:R:I335	R:R:W332	86.3232	4.7	No	Yes	0	6	9
39	R:R:P270	R:R:W332	64.8858	2.7	No	Yes	0	9	9
40	R:R:L336	R:R:P270	45.6092	9.85	No	No	0	9	9
41	R:R:I271	R:R:L336	44.794	2.85	No	No	0	9	9
42	R:R:I271	R:R:W520	42.1109	3.52	No	Yes	2	9	9
43	R:R:S251	R:R:T252	11.1837	1.6	No	No	0	6	6
44	R:R:P270	R:R:R269	24.0651	2.88	No	Yes	0	9	9
45	R:R:I272	R:R:R269	22.1655	2.51	Yes	Yes	1	7	9
46	R:R:F273	R:R:W332	22.2961	24.05	No	Yes	0	7	9
47	R:R:F273	R:R:R269	21.5007	3.21	No	Yes	0	7	9
48	R:R:F264	R:R:I272	14.1992	5.02	No	Yes	1	9	7
49	R:R:D260	R:R:R263	10.2022	15.48	No	No	0	8	9
50	R:R:F264	R:R:R263	12.2324	7.48	No	No	0	9	9
51	R:R:R265	R:R:R269	20.3886	3.2	No	Yes	1	6	9
52	R:R:R265	R:R:Y266	18.8729	4.12	No	Yes	0	6	9
53	R:R:I353	R:R:Y266	10.5821	3.63	Yes	Yes	0	9	9
54	R:R:I450	R:R:W520	36.1114	3.52	Yes	Yes	2	8	9
55	R:R:S330	R:R:Y411	20.0443	3.82	No	Yes	0	8	8
56	R:R:S330	R:R:Y457	18.9362	2.54	No	Yes	0	8	9
57	R:R:Y278	R:R:Y457	10.9541	2.98	Yes	Yes	11	9	9
58	R:R:F319	R:R:Y323	18.3505	7.22	Yes	Yes	0	9	9
59	R:R:C390	R:R:F319	21.5561	2.79	No	Yes	0	9	9
60	R:R:V392	R:R:Y391	10.036	3.79	No	Yes	0	9	5
61	R:R:C315	R:R:C390	14.3575	7.28	No	No	0	9	9
62	R:R:C315	R:R:T310	13.0753	1.69	No	Yes	0	9	6
63	R:R:F403	R:R:Y323	29.0633	5.16	Yes	Yes	0	8	9
64	R:R:I450	R:R:M447	35.8661	4.37	Yes	Yes	0	8	9
65	R:R:M447	R:R:W340	27.2468	4.65	Yes	Yes	0	9	9
66	R:R:G422	R:R:W340	18.0419	4.22	No	Yes	0	9	9
67	R:R:F341	R:R:G422	13.5937	3.01	Yes	No	0	8	9
68	R:R:F403	R:R:S399	27.2627	2.64	Yes	No	14	8	7
69	R:R:N396	R:R:Q395	24.7259	2.64	No	Yes	0	7	6
70	R:R:N396	R:R:S399	26.3564	8.94	No	No	0	7	7
71	R:R:V404	R:R:Y391	22.1932	3.79	No	Yes	0	8	5
72	R:R:L400	R:R:V404	19.6921	2.98	Yes	No	0	8	8
73	R:R:L400	R:R:R475	13.3009	2.43	Yes	No	0	8	6
74	R:R:L397	R:R:R475	12.0701	3.64	No	No	0	4	6
75	R:R:I463	R:R:M509	10.4753	5.83	No	Yes	0	5	8
76	R:R:Q395	R:R:Y307	20.1433	22.55	Yes	Yes	5	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 6WW2

PDB Summary
PDB	6WW2
Class	F
SubFamily	Protein
Type	Frizzled
SubType	FZD5
Species	Homo sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.7
Date	2020-08-19
D.O.I.	10.7554/eLife.58464

Net Summary
I_min	2.54
Number of Linked Nodes	290
Number of Links	318
Number of Hubs	38
Number of Links mediated by Hubs	144
Number of Communities	15
Number of Nodes involved in Communities	53
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	77
Number Of Links MetaPath	76
Number of Shortest Paths	51089
Length Of Smallest Path	3
Average Path Length	15.5595
Length of Longest Path	36
Minimum Path Strength	1.21
Average Path Strength	5.27949
Maximum Path Strength	18.115
Minimum Path Correlation	0.7
Average Path Correlation	0.944635
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	54.4831
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.8685
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q13467
Sequence	>6WW2_Chain_R R E P F V P I L K E S H P L Y N K V R T G Q V P N C A V P C Y Q P S F S A D E R T F A T F W I G L W S V L C F I S T S T T V A T F L I D M E R F R Y P E R P I I F L S A C Y L C V S L G F L V R L V V G H A S V A C S R E H N H I H Y E T T G P A L C T I V F L L V Y F F G M A S S I W W V I L S L T W F L A A G M K W G N E A I A G Y A Q Y F H L A A W L I P S V K S I T A L A L S S V D G D P V A G I C Y V G N Q N L N S L R G F V L G P L V L Y L L V G T L F L L A G F V S L F R D K L E K L M I R I G I F T L L Y T V P A S I V V A C Y L Y E Q H Y R E S W E A A L T C A C E Y W V L M L K Y F M C L V V G I T S G V W I W S G K T V E S W R R F T S R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6WW2.zip

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