psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F196	R:R:R193	8.55	No	No	0	6	5
2	R:R:A481	R:R:R193	2.77	No	No	0	5	5
3	R:R:F196	R:R:P221	5.78	No	No	0	6	7
4	R:R:F196	R:R:S226	6.61	No	No	0	6	4
5	R:R:I199	R:R:V197	3.07	No	No	0	4	5
6	R:R:I199	R:R:N217	4.25	No	No	0	4	5
7	R:R:E202	R:R:Y207	4.49	No	Yes	0	4	5
8	R:R:H204	R:R:N208	11.48	No	No	0	4	5
9	R:R:L206	R:R:P205	3.28	No	No	0	3	3
10	R:R:P205	R:R:Y207	6.95	No	Yes	0	3	5
11	R:R:L206	R:R:V210	4.47	No	No	0	3	6
12	R:R:L206	R:R:Y307	4.69	No	Yes	0	3	6
13	R:R:H302	R:R:Y207	11.98	No	Yes	0	3	5
14	R:R:K209	R:R:N208	16.79	No	No	0	5	5
15	R:R:T212	R:R:V210	4.76	No	No	0	5	6
16	R:R:A219	R:R:T212	5.03	No	No	0	7	5
17	R:R:E479	R:R:G213	3.27	No	Yes	0	6	4
18	R:R:P216	R:R:V215	3.53	No	No	0	2	5
19	R:R:C218	R:R:V215	5.12	No	No	0	9	5
20	R:R:P221	R:R:V220	3.53	No	No	0	7	5
21	R:R:P221	R:R:P225	3.9	No	No	0	7	6
22	R:R:C222	R:R:H293	2.95	No	Yes	0	9	6
23	R:R:C222	R:R:C298	7.28	No	No	0	9	9
24	R:R:R232	R:R:Y223	11.32	No	No	0	6	4
25	R:R:H293	R:R:Y223	5.44	Yes	No	0	6	4
26	R:R:P225	R:R:Q224	3.16	No	No	0	6	5
27	R:R:F227	R:R:Q224	3.51	No	No	0	8	5
28	R:R:P385	R:R:Q224	4.74	No	No	0	7	5
29	R:R:F227	R:R:W478	17.04	No	No	0	8	9
30	R:R:E499	R:R:F227	3.5	No	No	0	5	8
31	R:R:E231	R:R:S228	2.87	No	No	7	7	4
32	R:R:S228	R:R:Y500	6.36	No	Yes	7	4	6
33	R:R:A229	R:R:D230	3.09	No	No	0	3	3
34	R:R:E231	R:R:Y500	14.59	No	Yes	7	7	6
35	R:R:F234	R:R:W238	9.02	No	No	0	7	9
36	R:R:F234	R:R:Y500	6.19	No	Yes	0	7	6
37	R:R:A235	R:R:Y500	2.67	No	Yes	0	6	6
38	R:R:W238	R:R:W242	13.12	No	No	0	9	8
39	R:R:M504	R:R:W238	5.82	No	No	0	8	9
40	R:R:F508	R:R:W242	22.05	No	No	0	8	8
41	R:R:F285	R:R:S243	2.64	No	No	0	7	8
42	R:R:L286	R:R:S243	3	No	No	0	5	8
43	R:R:I515	R:R:L245	4.28	No	No	0	8	6
44	R:R:C246	R:R:L511	6.35	No	No	0	9	8
45	R:R:C246	R:R:I515	3.27	No	No	0	9	8
46	R:R:F247	R:R:I248	3.77	Yes	No	8	6	3
47	R:R:F247	R:R:S251	10.57	Yes	No	8	6	6
48	R:R:F247	R:R:S282	3.96	Yes	No	0	6	8
49	R:R:F247	R:R:L286	3.65	Yes	No	0	6	5
50	R:R:I248	R:R:S251	4.64	No	No	8	3	6
51	R:R:I515	R:R:S249	6.19	No	No	0	8	8
52	R:R:T250	R:R:T253	3.14	No	No	9	8	9
53	R:R:L279	R:R:T250	7.37	No	No	0	6	8
54	R:R:S517	R:R:T250	3.2	No	No	9	9	8
55	R:R:T252	R:R:T256	3.14	No	No	0	6	9
56	R:R:T252	R:R:W530	3.64	No	Yes	0	6	9
57	R:R:S517	R:R:T253	3.2	No	No	9	9	9
58	R:R:I521	R:R:T253	6.08	No	No	0	7	9
59	R:R:F257	R:R:L258	3.65	No	No	0	9	7
60	R:R:F257	R:R:F264	6.43	No	No	1	9	9
61	R:R:F257	R:R:I272	16.33	No	Yes	1	9	7
62	R:R:I259	R:R:W530	10.57	No	Yes	0	8	9
63	R:R:F533	R:R:I259	3.77	No	No	0	6	8
64	R:R:D260	R:R:R263	15.48	No	No	0	8	9
65	R:R:D260	R:R:T526	4.34	No	No	0	8	9
66	R:R:E262	R:R:R265	23.26	No	No	1	4	6
67	R:R:E262	R:R:R269	11.63	No	Yes	1	4	9
68	R:R:F264	R:R:R263	7.48	No	No	0	9	9
69	R:R:F264	R:R:I272	5.02	No	Yes	1	9	7
70	R:R:R265	R:R:Y266	4.12	No	Yes	0	6	9
71	R:R:R265	R:R:R269	3.2	No	Yes	1	6	9
72	R:R:I353	R:R:Y266	3.63	Yes	Yes	0	9	9
73	R:R:A354	R:R:Y266	9.34	No	Yes	0	7	9
74	R:R:E268	R:R:P267	12.58	No	No	0	9	9
75	R:R:N350	R:R:P267	4.89	No	No	10	7	9
76	R:R:I353	R:R:P267	5.08	Yes	No	10	9	9
77	R:R:E268	R:R:I450	4.1	No	Yes	0	9	8
78	R:R:P270	R:R:R269	2.88	No	Yes	0	9	9
79	R:R:F273	R:R:R269	3.21	No	Yes	0	7	9
80	R:R:P270	R:R:W332	2.7	No	Yes	0	9	9
81	R:R:L336	R:R:P270	9.85	No	No	0	9	9
82	R:R:I271	R:R:L336	2.85	No	No	0	9	9
83	R:R:F453	R:R:I271	5.02	No	No	2	9	9
84	R:R:I271	R:R:W520	3.52	No	Yes	2	9	9
85	R:R:F273	R:R:W332	24.05	No	Yes	0	7	9
86	R:R:L274	R:R:Y278	3.52	No	Yes	0	8	9
87	R:R:S275	R:R:S517	6.52	No	No	0	8	9
88	R:R:C277	R:R:F325	4.19	No	No	0	9	9
89	R:R:C277	R:R:S329	3.44	No	No	0	9	8
90	R:R:S329	R:R:Y278	6.36	No	Yes	0	8	9
91	R:R:Y278	R:R:Y457	2.98	Yes	Yes	11	9	9
92	R:R:V513	R:R:Y278	11.36	No	Yes	11	8	9
93	R:R:G514	R:R:Y278	4.35	No	Yes	0	9	9
94	R:R:C280	R:R:F325	18.15	No	No	0	6	9
95	R:R:L283	R:R:L286	2.77	No	No	0	4	5
96	R:R:L283	R:R:L321	4.15	No	No	0	4	6
97	R:R:F285	R:R:I389	3.77	No	Yes	0	7	7
98	R:R:V287	R:R:V318	3.21	No	No	12	5	9
99	R:R:L289	R:R:R288	3.64	No	Yes	0	5	9
100	R:R:H293	R:R:R288	4.51	Yes	Yes	6	6	9
101	R:R:G388	R:R:R288	3	No	Yes	6	9	9
102	R:R:G388	R:R:H293	9.53	No	Yes	6	9	6
103	R:R:R300	R:R:S295	2.64	No	No	0	3	4
104	R:R:L314	R:R:V296	4.47	No	No	0	4	6
105	R:R:H304	R:R:S299	4.18	No	No	0	4	4
106	R:R:H302	R:R:H304	3.58	No	No	0	3	4
107	R:R:I305	R:R:Y307	6.04	No	Yes	0	5	6
108	R:R:H306	R:R:T310	4.11	No	Yes	0	7	6
109	R:R:D382	R:R:Y307	3.45	Yes	Yes	5	8	6
110	R:R:Q395	R:R:Y307	22.55	Yes	Yes	5	6	6
111	R:R:E308	R:R:S379	11.5	No	No	0	7	6
112	R:R:E308	R:R:Q395	6.37	No	Yes	0	7	6
113	R:R:L376	R:R:T309	5.9	No	No	0	8	6
114	R:R:S379	R:R:T309	3.2	No	No	0	6	6
115	R:R:G311	R:R:T310	3.64	No	Yes	0	6	6
116	R:R:G311	R:R:P312	4.06	No	No	0	6	7
117	R:R:C315	R:R:C390	7.28	No	No	0	9	9
118	R:R:F319	R:R:Y323	7.22	Yes	Yes	0	9	9
119	R:R:F319	R:R:V381	7.87	Yes	No	0	9	8
120	R:R:C390	R:R:F319	2.79	No	Yes	0	9	9
121	R:R:F319	R:R:V392	2.62	Yes	No	0	9	9
122	R:R:M327	R:R:Y323	11.97	Yes	Yes	0	9	9
123	R:R:Y323	R:R:Y391	6.95	Yes	Yes	0	9	5
124	R:R:F403	R:R:Y323	5.16	Yes	Yes	0	8	9
125	R:R:F324	R:R:F325	9.65	Yes	No	0	8	9
126	R:R:F324	R:R:P368	4.33	Yes	No	0	8	9
127	R:R:F324	R:R:S369	5.28	Yes	No	0	8	7
128	R:R:G326	R:R:S329	3.71	No	No	0	7	8
129	R:R:K371	R:R:M327	2.88	No	Yes	0	7	9
130	R:R:M327	R:R:P407	5.03	Yes	No	13	9	9
131	R:R:M327	R:R:Y411	3.59	Yes	Yes	13	9	8
132	R:R:A328	R:R:W365	2.59	No	No	0	9	9
133	R:R:A328	R:R:P368	3.74	No	No	0	9	9
134	R:R:S330	R:R:Y411	3.82	No	Yes	0	8	8
135	R:R:S330	R:R:Y457	2.54	No	Yes	0	8	9
136	R:R:I331	R:R:Y411	10.88	No	Yes	0	6	8
137	R:R:I335	R:R:W332	4.7	No	Yes	0	6	9
138	R:R:W332	R:R:W365	12.18	Yes	No	0	9	9
139	R:R:G415	R:R:W333	2.81	No	No	0	9	9
140	R:R:W333	R:R:Y457	27.01	No	Yes	0	9	9
141	R:R:G415	R:R:S337	3.71	No	No	0	9	8
142	R:R:F418	R:R:L338	6.09	No	No	0	8	5
143	R:R:A344	R:R:W340	7.78	No	Yes	0	9	9
144	R:R:L419	R:R:W340	3.42	Yes	Yes	3	8	9
145	R:R:G422	R:R:W340	4.22	No	Yes	0	9	9
146	R:R:F423	R:R:W340	8.02	No	Yes	3	7	9
147	R:R:M447	R:R:W340	4.65	Yes	Yes	0	9	9
148	R:R:F341	R:R:M346	7.46	Yes	No	0	8	7
149	R:R:F341	R:R:F418	7.5	Yes	No	0	8	8
150	R:R:A421	R:R:F341	5.55	No	Yes	0	6	8
151	R:R:F341	R:R:G422	3.01	Yes	No	0	8	9
152	R:R:L342	R:R:W348	7.97	No	Yes	0	9	9
153	R:R:G345	R:R:M346	3.49	No	No	0	6	7
154	R:R:G345	R:R:S425	3.71	No	No	0	6	9
155	R:R:M346	R:R:W348	13.96	No	Yes	0	7	9
156	R:R:W348	R:R:Y356	3.86	Yes	No	0	9	6
157	R:R:I353	R:R:N350	2.83	Yes	No	10	9	7
158	R:R:F360	R:R:Y356	5.16	No	No	0	8	6
159	R:R:H361	R:R:L362	2.57	No	No	0	9	6
160	R:R:I367	R:R:P368	3.39	No	No	0	5	9
161	R:R:K371	R:R:T374	3	No	No	0	7	5
162	R:R:I373	R:R:L376	2.85	No	No	0	7	8
163	R:R:A375	R:R:F403	5.55	No	Yes	0	6	8
164	R:R:L378	R:R:S380	3	No	No	0	6	6
165	R:R:S380	R:R:S399	6.52	No	No	14	6	7
166	R:R:F403	R:R:S380	3.96	Yes	No	14	8	6
167	R:R:D382	R:R:N394	5.39	Yes	No	0	8	7
168	R:R:D382	R:R:Q395	7.83	Yes	Yes	5	8	6
169	R:R:D384	R:R:P385	3.22	No	No	0	9	7
170	R:R:D384	R:R:I389	4.2	No	Yes	0	9	7
171	R:R:D384	R:R:N394	5.39	No	No	0	9	7
172	R:R:L503	R:R:V386	5.96	No	No	0	7	8
173	R:R:A387	R:R:I389	6.5	No	Yes	0	8	7
174	R:R:A387	R:R:Y507	4	No	No	0	8	8
175	R:R:I389	R:R:Y391	3.63	Yes	Yes	0	7	5
176	R:R:V392	R:R:Y391	3.79	No	Yes	0	9	5
177	R:R:V404	R:R:Y391	3.79	No	Yes	0	8	5
178	R:R:F403	R:R:V392	9.18	Yes	No	0	8	9
179	R:R:G393	R:R:L400	3.42	No	Yes	0	8	8
180	R:R:N396	R:R:Q395	2.64	No	Yes	0	7	6
181	R:R:N396	R:R:N398	2.72	No	No	0	7	3
182	R:R:N396	R:R:S399	8.94	No	No	0	7	7
183	R:R:L397	R:R:Q472	3.99	No	Yes	4	4	5
184	R:R:L397	R:R:R475	3.64	No	No	0	4	6
185	R:R:E476	R:R:L397	2.65	No	No	4	4	4
186	R:R:F403	R:R:S399	2.64	Yes	No	14	8	7
187	R:R:L400	R:R:V404	2.98	Yes	No	0	8	8
188	R:R:L400	R:R:L405	11.07	Yes	No	0	8	7
189	R:R:L405	R:R:R401	3.64	No	No	0	7	5
190	R:R:G406	R:R:P407	4.06	No	No	0	5	9
191	R:R:P407	R:R:Y411	8.34	No	Yes	13	9	8
192	R:R:L413	R:R:V409	2.98	No	No	0	4	4
193	R:R:L410	R:R:Y411	5.86	No	Yes	0	4	8
194	R:R:L412	R:R:S462	6.01	No	No	0	8	5
195	R:R:F423	R:R:L419	4.87	No	Yes	3	7	8
196	R:R:L419	R:R:T454	7.37	Yes	No	3	8	8
197	R:R:L419	R:R:L455	5.54	Yes	No	3	8	7
198	R:R:G422	R:R:S425	3.71	No	No	0	9	9
199	R:R:F423	R:R:L455	3.65	No	No	3	7	7
200	R:R:L426	R:R:L443	2.77	No	No	0	8	8
201	R:R:I448	R:R:L426	2.85	No	No	0	7	8
202	R:R:L443	R:R:M447	2.83	No	Yes	0	8	9
203	R:R:K445	R:R:L446	2.82	No	No	0	7	8
204	R:R:I450	R:R:M447	4.37	Yes	Yes	0	8	9
205	R:R:I450	R:R:R449	3.76	Yes	No	2	8	9
206	R:R:R449	R:R:W520	10	No	Yes	2	9	9
207	R:R:I450	R:R:W520	3.52	Yes	Yes	2	8	9
208	R:R:G451	R:R:T454	3.64	No	No	0	8	8
209	R:R:F453	R:R:T516	7.78	No	No	0	9	8
210	R:R:F453	R:R:W520	7.02	No	Yes	2	9	9
211	R:R:L455	R:R:T454	4.42	No	No	3	7	8
212	R:R:V513	R:R:Y457	7.57	No	Yes	11	8	9
213	R:R:P460	R:R:V459	3.53	No	No	0	8	8
214	R:R:I463	R:R:M509	5.83	No	Yes	0	5	8
215	R:R:M509	R:R:V464	4.56	Yes	No	0	8	7
216	R:R:C467	R:R:K506	8.08	No	Yes	0	8	9
217	R:R:C467	R:R:M509	3.24	No	Yes	0	8	8
218	R:R:K506	R:R:Y468	15.53	Yes	No	0	9	4
219	R:R:L469	R:R:Q472	3.99	No	Yes	0	5	5
220	R:R:E471	R:R:K506	4.05	No	Yes	0	9	9
221	R:R:H473	R:R:Q472	3.71	No	Yes	4	4	5
222	R:R:E476	R:R:Q472	8.92	No	Yes	4	4	5
223	R:R:E476	R:R:H473	3.69	No	No	4	4	4
224	R:R:W478	R:R:Y474	12.54	No	No	0	9	4
225	R:R:E499	R:R:Y474	12.35	No	No	0	5	4
226	R:R:S477	R:R:W478	12.36	No	No	0	2	9
227	R:R:E499	R:R:V502	4.28	No	No	0	5	6
228	R:R:M504	R:R:Y500	7.18	No	Yes	0	8	6
229	R:R:V502	R:R:W501	7.36	No	No	0	6	6
230	R:R:L503	R:R:Y507	3.52	No	No	0	7	8
231	R:R:L505	R:R:M509	9.9	No	Yes	0	7	8
232	R:R:K506	R:R:Y507	4.78	Yes	No	0	9	8
233	R:R:F508	R:R:V512	6.55	No	No	0	8	7
234	R:R:I521	R:R:W520	3.52	No	Yes	0	7	9
235	R:R:E528	R:R:R531	16.28	No	No	15	4	5
236	R:R:E528	R:R:R532	10.47	No	No	15	4	4
237	R:R:T534	R:R:W530	6.06	No	Yes	0	4	9
238	R:R:R531	R:R:R532	4.26	No	No	15	5	4
239	R:R:R532	R:R:S535	5.27	No	No	0	4	4
240	R:R:F533	R:R:R536	10.69	No	No	0	6	7
241	R:R:V322	R:R:Y391	2.52	No	Yes	0	5	5
242	R:R:F285	R:R:I239	2.51	No	No	0	7	6
243	R:R:I272	R:R:R269	2.51	Yes	Yes	1	7	9
244	R:R:V334	R:R:W333	2.45	No	No	0	8	9
245	R:R:F427	R:R:L426	2.44	No	No	0	6	8
246	R:R:F508	R:R:L505	2.44	No	No	0	8	7
247	R:R:L400	R:R:R475	2.43	Yes	No	0	8	6
248	R:R:K201	R:R:Y207	2.39	No	Yes	0	3	5
249	R:R:L245	R:R:W242	2.28	No	No	0	6	8
250	R:R:H361	R:R:W332	2.12	No	Yes	0	9	9
251	R:R:A297	R:R:G383	1.95	No	No	0	8	8
252	R:R:A354	R:R:G355	1.95	No	No	0	7	5
253	R:R:A387	R:R:G388	1.95	No	No	0	8	9
254	R:R:C218	R:R:P198	1.88	No	No	0	9	4
255	R:R:G240	R:R:S243	1.86	No	No	0	4	8
256	R:R:G518	R:R:S249	1.86	No	No	0	7	8
257	R:R:G213	R:R:V215	1.84	Yes	No	0	4	5
258	R:R:G326	R:R:V281	1.84	No	No	0	7	8
259	R:R:G284	R:R:V287	1.84	No	No	12	7	5
260	R:R:G284	R:R:V318	1.84	No	No	12	7	9
261	R:R:G292	R:R:V291	1.84	No	No	0	8	5
262	R:R:G518	R:R:V519	1.84	No	No	0	7	7
263	R:R:G524	R:R:V527	1.84	No	No	0	5	4
264	R:R:G345	R:R:K347	1.74	No	No	0	6	9
265	R:R:G213	R:R:L482	1.71	Yes	No	0	4	6
266	R:R:G284	R:R:L321	1.71	No	No	0	7	6
267	R:R:C390	R:R:V318	1.71	No	No	0	9	9
268	R:R:A219	R:R:V197	1.7	No	No	0	7	5
269	R:R:A297	R:R:V296	1.7	No	No	0	8	6
270	R:R:C315	R:R:T310	1.69	No	Yes	0	9	6
271	R:R:A313	R:R:T316	1.68	No	Yes	0	6	8
272	R:R:D382	R:R:G383	1.68	Yes	No	0	8	8
273	R:R:G213	R:R:Q214	1.64	Yes	No	0	4	4
274	R:R:G355	R:R:Q358	1.64	No	No	0	5	7
275	R:R:S295	R:R:V291	1.62	No	No	0	4	5
276	R:R:A364	R:R:I331	1.62	No	No	0	9	6
277	R:R:A364	R:R:I335	1.62	No	No	0	9	6
278	R:R:S251	R:R:T252	1.6	No	No	0	6	6
279	R:R:V290	R:R:V291	1.6	No	No	0	3	5
280	R:R:V334	R:R:V414	1.6	No	No	0	8	5
281	R:R:V409	R:R:V465	1.6	No	No	0	4	7
282	R:R:S523	R:R:T526	1.6	No	No	0	9	9
283	R:R:S529	R:R:T526	1.6	No	No	0	8	9
284	R:R:T458	R:R:V459	1.59	No	No	0	7	8
285	R:R:A461	R:R:L412	1.58	No	No	0	8	8
286	R:R:E194	R:R:P195	1.57	No	No	0	2	5
287	R:R:T309	R:R:T316	1.57	No	Yes	0	6	8
288	R:R:T310	R:R:T316	1.57	Yes	Yes	0	6	8
289	R:R:T416	R:R:T458	1.57	No	No	0	6	7
290	R:R:I373	R:R:S372	1.55	No	No	0	7	8
291	R:R:I272	R:R:V254	1.54	Yes	No	0	7	7
292	R:R:I463	R:R:V459	1.54	No	No	0	5	8
293	R:R:K525	R:R:S523	1.53	No	No	0	9	9
294	R:R:I317	R:R:T316	1.52	No	Yes	0	5	8
295	R:R:I353	R:R:T339	1.52	Yes	No	0	9	8
296	R:R:G292	R:R:R288	1.5	No	Yes	0	8	9
297	R:R:G402	R:R:R401	1.5	No	No	0	4	5
298	R:R:L408	R:R:V404	1.49	No	No	0	8	8
299	R:R:L469	R:R:V465	1.49	No	No	0	5	7
300	R:R:L412	R:R:T416	1.47	No	No	0	8	6
301	R:R:I448	R:R:I452	1.47	No	No	0	7	5
302	R:R:L482	R:R:T483	1.47	No	No	0	6	5
303	R:R:E479	R:R:T212	1.41	No	No	0	6	5
304	R:R:L446	R:R:M447	1.41	No	Yes	0	8	9
305	R:R:K201	R:R:N208	1.4	No	No	0	3	5
306	R:R:H204	R:R:S203	1.39	No	No	0	4	4
307	R:R:A363	R:R:F360	1.39	No	No	0	7	8
308	R:R:L419	R:R:L420	1.38	Yes	No	0	8	6
309	R:R:E444	R:R:I448	1.37	No	No	0	9	7
310	R:R:A294	R:R:Y223	1.33	No	No	0	5	4
311	R:R:A357	R:R:Y266	1.33	No	Yes	0	8	9
312	R:R:A352	R:R:W348	1.3	No	Yes	0	9	9
313	R:R:V527	R:R:W530	1.23	No	Yes	0	4	9
314	R:R:F324	R:R:L320	1.22	Yes	No	0	8	8
315	R:R:D230	R:R:R232	1.19	No	No	0	3	6
316	R:R:Q214	R:R:R211	1.17	No	No	0	4	2
317	R:R:F360	R:R:Y359	1.03	No	No	0	8	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y207	6.4525	4	0	5
2	R:R:G213	2.115	4	0	4
3	R:R:F247	5.4875	4	8	6
4	R:R:Y266	4.605	4	0	9
5	R:R:R269	4.686	5	1	9
6	R:R:I272	6.35	4	1	7
7	R:R:Y278	5.714	5	11	9
8	R:R:R288	3.1625	4	6	9
9	R:R:H293	5.6075	4	6	6
10	R:R:Y307	9.1825	4	5	6
11	R:R:T310	2.7525	4	0	6
12	R:R:T316	1.585	4	0	8
13	R:R:F319	5.125	4	0	9
14	R:R:Y323	7.825	4	0	9
15	R:R:F324	5.12	4	0	8
16	R:R:M327	5.8675	4	13	9
17	R:R:W332	9.15	5	0	9
18	R:R:W340	5.618	5	3	9
19	R:R:F341	5.88	4	0	8
20	R:R:W348	6.7725	4	0	9
21	R:R:I353	3.265	4	10	9
22	R:R:D382	4.5875	4	5	8
23	R:R:I389	4.525	4	0	7
24	R:R:Y391	4.136	5	0	5
25	R:R:Q395	9.8475	4	5	6
26	R:R:L400	4.975	4	0	8
27	R:R:F403	5.298	5	14	8
28	R:R:Y411	6.498	5	13	8
29	R:R:L419	4.516	5	3	8
30	R:R:M447	3.315	4	0	9
31	R:R:I450	3.9375	4	2	8
32	R:R:Y457	10.025	4	11	9
33	R:R:Q472	5.1525	4	4	5
34	R:R:Y500	7.398	5	7	6
35	R:R:K506	8.11	4	0	9
36	R:R:M509	5.8825	4	0	8
37	R:R:W520	5.516	5	2	9
38	R:R:W530	5.375	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P385	R:R:Q224	20.1663	4.74	No	No	0	7	5
2	R:R:D384	R:R:P385	21.3634	3.22	No	No	0	9	7
3	R:R:D384	R:R:N394	23.7055	5.39	No	No	0	9	7
4	R:R:D382	R:R:N394	22.8538	5.39	Yes	No	0	8	7
5	R:R:D382	R:R:Y307	14.4137	3.45	Yes	Yes	5	8	6
6	R:R:L206	R:R:Y307	32.5192	4.69	No	Yes	0	3	6
7	R:R:L206	R:R:V210	19.395	4.47	No	No	0	3	6
8	R:R:T212	R:R:V210	18.2381	4.76	No	No	0	5	6
9	R:R:P205	R:R:Y207	12.3408	6.95	No	Yes	0	3	5
10	R:R:L206	R:R:P205	13.5379	3.28	No	No	0	3	3
11	R:R:E479	R:R:T212	12.3328	1.41	No	No	0	6	5
12	R:R:E479	R:R:G213	11.1276	3.27	No	Yes	0	6	4
13	R:R:G388	R:R:H293	10.276	9.53	No	Yes	6	9	6
14	R:R:A387	R:R:G388	20.56	1.95	No	No	0	8	9
15	R:R:A387	R:R:I389	63.1422	6.5	No	Yes	0	8	7
16	R:R:D384	R:R:I389	39.1917	4.2	No	Yes	0	9	7
17	R:R:F227	R:R:Q224	10.3001	3.51	No	No	0	8	5
18	R:R:W238	R:R:W242	14.4016	13.12	No	No	0	9	8
19	R:R:F508	R:R:W242	24.2679	22.05	No	No	0	8	8
20	R:R:F508	R:R:L505	26.6541	2.44	No	No	0	8	7
21	R:R:L505	R:R:M509	27.8351	9.9	No	Yes	0	7	8
22	R:R:C467	R:R:M509	39.2038	3.24	No	Yes	0	8	8
23	R:R:C467	R:R:K506	40.2965	8.08	No	Yes	0	8	9
24	R:R:K506	R:R:Y507	43.5263	4.78	Yes	No	0	9	8
25	R:R:A387	R:R:Y507	46.6838	4	No	No	0	8	8
26	R:R:F285	R:R:I389	23.0025	3.77	No	Yes	0	7	7
27	R:R:F285	R:R:S243	20.6644	2.64	No	No	0	7	8
28	R:R:L286	R:R:S243	18.3827	3	No	No	0	5	8
29	R:R:F247	R:R:L286	16.1652	3.65	Yes	No	0	6	5
30	R:R:F247	R:R:S251	12.4734	10.57	Yes	No	8	6	6
31	R:R:I389	R:R:Y391	78.1103	3.63	Yes	Yes	0	7	5
32	R:R:Y323	R:R:Y391	73.4745	6.95	Yes	Yes	0	9	5
33	R:R:M327	R:R:Y323	100	11.97	Yes	Yes	0	9	9
34	R:R:M327	R:R:Y411	97.7664	3.59	Yes	Yes	13	9	8
35	R:R:I331	R:R:Y411	87.1852	10.88	No	Yes	0	6	8
36	R:R:A364	R:R:I331	86.7674	1.62	No	No	0	9	6
37	R:R:A364	R:R:I335	86.3576	1.62	No	No	0	9	6
38	R:R:I335	R:R:W332	85.9479	4.7	No	Yes	0	6	9
39	R:R:P270	R:R:W332	64.962	2.7	No	Yes	0	9	9
40	R:R:L336	R:R:P270	46.2941	9.85	No	No	0	9	9
41	R:R:I271	R:R:L336	45.4666	2.85	No	No	0	9	9
42	R:R:I271	R:R:W520	42.7389	3.52	No	Yes	2	9	9
43	R:R:S251	R:R:T252	11.2803	1.6	No	No	0	6	6
44	R:R:P270	R:R:R269	23.5167	2.88	No	Yes	0	9	9
45	R:R:I272	R:R:R269	22.4561	2.51	Yes	Yes	1	7	9
46	R:R:F273	R:R:W332	21.729	24.05	No	Yes	0	7	9
47	R:R:F273	R:R:R269	20.9175	3.21	No	Yes	0	7	9
48	R:R:F264	R:R:I272	14.3856	5.02	No	Yes	1	9	7
49	R:R:D260	R:R:R263	10.3362	15.48	No	No	0	8	9
50	R:R:F264	R:R:R263	12.393	7.48	No	No	0	9	9
51	R:R:R265	R:R:R269	18.8286	3.2	No	Yes	1	6	9
52	R:R:R265	R:R:Y266	17.282	4.12	No	Yes	0	6	9
53	R:R:I450	R:R:W520	36.6127	3.52	Yes	Yes	2	8	9
54	R:R:S330	R:R:Y411	20.2587	3.82	No	Yes	0	8	8
55	R:R:S330	R:R:Y457	19.1419	2.54	No	Yes	0	8	9
56	R:R:Y278	R:R:Y457	11.0955	2.98	Yes	Yes	11	9	9
57	R:R:F319	R:R:Y323	18.459	7.22	Yes	Yes	0	9	9
58	R:R:C390	R:R:F319	21.737	2.79	No	Yes	0	9	9
59	R:R:V392	R:R:Y391	10.1796	3.79	No	Yes	0	9	5
60	R:R:C315	R:R:C390	14.478	7.28	No	No	0	9	9
61	R:R:C315	R:R:T310	13.1844	1.69	No	Yes	0	9	6
62	R:R:F403	R:R:Y323	29.1327	5.16	Yes	Yes	0	8	9
63	R:R:I450	R:R:M447	36.2712	4.37	Yes	Yes	0	8	9
64	R:R:M447	R:R:W340	27.5579	4.65	Yes	Yes	0	9	9
65	R:R:G422	R:R:W340	18.2501	4.22	No	Yes	0	9	9
66	R:R:F341	R:R:G422	13.7509	3.01	Yes	No	0	8	9
67	R:R:F403	R:R:S399	27.345	2.64	Yes	No	14	8	7
68	R:R:N396	R:R:Q395	24.7941	2.64	No	Yes	0	7	6
69	R:R:N396	R:R:S399	26.4331	8.94	No	No	0	7	7
70	R:R:V404	R:R:Y391	22.3918	3.79	No	Yes	0	8	5
71	R:R:L400	R:R:V404	19.869	2.98	Yes	No	0	8	8
72	R:R:L400	R:R:R475	13.4214	2.43	Yes	No	0	8	6
73	R:R:L397	R:R:R475	12.1801	3.64	No	No	0	4	6
74	R:R:I463	R:R:M509	10.5692	5.83	No	Yes	0	5	8
75	R:R:Q395	R:R:Y307	20.2065	22.55	Yes	Yes	5	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 6WW2

PDB Summary
PDB	6WW2
Class	F
SubFamily	Protein
Type	Frizzled
SubType	FZD5
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.7
Date	2020-08-19
D.O.I.	doi.org/10.7554/eLife.58464

Net Summary
I_min	2.54
Number of Linked Nodes	289
Number of Links	317
Number of Hubs	38
Number of Links mediated by Hubs	144
Number of Communities	15
Number of Nodes involved in Communities	53
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	50566
Length Of Smallest Path	3
Average Path Length	15.5349
Length of Longest Path	36
Minimum Path Strength	1.21
Average Path Strength	5.27968
Maximum Path Strength	18.115
Minimum Path Correlation	0.7
Average Path Correlation	0.944429
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	54.5524
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.8154
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • transmembrane signaling receptor activity • signaling receptor activity • Wnt receptor activity • amide binding • amyloid-beta binding • peptide binding • protein-containing complex binding • ubiquitin protein ligase binding • protein binding • ubiquitin-like protein ligase binding • enzyme binding • Wnt-protein binding • G protein-coupled receptor activity • kinase binding • protein kinase binding • lipid binding • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • developmental process • multicellular organismal process • sensory organ development • post-embryonic camera-type eye development • eye development • animal organ development • visual system development • multicellular organism development • camera-type eye development • anatomical structure development
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • developmental process • multicellular organismal process • sensory organ development • post-embryonic camera-type eye development • eye development • animal organ development • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • post-embryonic development • sensory system development • system development • adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • regulation of immune effector process • lymphocyte mediated immunity • T cell mediated immunity • positive regulation of leukocyte mediated immunity • regulation of cellular process • response to stimulus • T cell cytokine production • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of immune response • cytokine production • leukocyte mediated immunity • regulation of immune system process • positive regulation of macromolecule metabolic process • positive regulation of adaptive immune response • positive regulation of T cell cytokine production • positive regulation of immune system process • regulation of T cell mediated immunity • regulation of biological process • regulation of cytokine production involved in immune response • immune response • regulation of adaptive immune response • immune effector process • regulation of gene expression • regulation of leukocyte mediated immunity • biosynthetic process • regulation of response to stimulus • positive regulation of production of molecular mediator of immune response • positive regulation of multicellular organismal process • regulation of immune response • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of production of molecular mediator of immune response • positive regulation of cytokine production • regulation of metabolic process • positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • positive regulation of lymphocyte mediated immunity • positive regulation of biological process • positive regulation of response to stimulus • regulation of T cell cytokine production • regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • positive regulation of biosynthetic process • regulation of cytokine production • positive regulation of immune effector process • regulation of multicellular organismal process • cytokine production involved in immune response • positive regulation of cellular process • production of molecular mediator of immune response • regulation of biosynthetic process • biological regulation • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • adaptive immune response • regulation of lymphocyte mediated immunity • positive regulation of gene expression • immune system process • positive regulation of T cell mediated immunity • positive regulation of cytokine production involved in immune response • cellular response to stimulus • cell surface receptor signaling pathway • signaling • canonical Wnt signaling pathway • cell communication • signal transduction • Wnt signaling pathway • cell differentiation involved in embryonic placenta development • cellular developmental process • placenta development • reproductive process • syncytiotrophoblast cell differentiation involved in labyrinthine layer development • chordate embryonic development • labyrinthine layer development • developmental process involved in reproduction • embryo development • in utero embryonic development • embryonic placenta development • embryo development ending in birth or egg hatching • cell differentiation • embryonic organ development • cell development • epithelial cell differentiation • intestinal epithelial cell maturation • columnar/cuboidal epithelial cell development • cell maturation • epithelium development • digestive system development • intestinal epithelial cell differentiation • tube development • intestinal epithelial cell development • developmental maturation • tissue development • digestive tract development • epithelial cell development • anatomical structure maturation • columnar/cuboidal epithelial cell differentiation • epithelial cell maturation • columnar/cuboidal epithelial cell maturation • embryonic morphogenesis • morphogenesis of an epithelium • branching involved in labyrinthine layer morphogenesis • embryonic placenta morphogenesis • anatomical structure morphogenesis • labyrinthine layer morphogenesis • tissue morphogenesis • morphogenesis of a branching structure • morphogenesis of a branching epithelium • interleukin-1 production • regulation of interleukin-1 beta production • positive regulation of interleukin-1 beta production • positive regulation of interleukin-1 production • regulation of interleukin-1 production • interleukin-1 beta production • hemopoiesis • cell activation • mononuclear cell differentiation • lymphocyte activation • lymphocyte differentiation • leukocyte activation • T cell differentiation in thymus • T cell activation • T cell differentiation • leukocyte differentiation • catabolic process • macroautophagy • autophagy • regulation of mitophagy • regulation of catabolic process • regulation of autophagy • regulation of macroautophagy • mitophagy • regulation of autophagy of mitochondrion • process utilizing autophagic mechanism • autophagy of mitochondrion • glandular epithelial cell development • glandular epithelial cell maturation • glandular epithelial cell differentiation • embryonic eye morphogenesis • embryonic camera-type eye development • eye morphogenesis • animal organ morphogenesis • embryonic organ morphogenesis • camera-type eye morphogenesis • embryonic camera-type eye morphogenesis • sensory organ morphogenesis • nervous system development • cellular component organization • cellular component biogenesis • cell junction organization • cellular component assembly • cell junction assembly • synapse organization • cellular component organization or biogenesis • synapse assembly • positive regulation of DNA-templated transcription • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • primary metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • apoptotic process involved in development • apoptotic process involved in morphogenesis • apoptotic process • cell death • programmed cell death • labyrinthine layer blood vessel development • placenta blood vessel development • vasculature development • circulatory system development • blood vessel development • blood vessel morphogenesis • angiogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • cell population proliferation • regulation of cell population proliferation • regulation of chorionic trophoblast cell proliferation • chorionic trophoblast cell proliferation • non-canonical Wnt signaling pathway • blastoderm segmentation • embryonic pattern specification • anterior/posterior axis specification, embryo • anterior/posterior pattern specification • segmentation • pattern specification process • regionalization • tripartite regional subdivision • embryonic axis specification • anterior/posterior axis specification • axis specification • extraembryonic membrane development • chorion development • chorionic trophoblast cell differentiation • generation of neurons • neurogenesis • neuron differentiation • bicellular tight junction assembly • regulation of bicellular tight junction assembly • regulation of cellular component organization • tight junction organization • apical junction assembly • regulation of cellular component biogenesis • regulation of cell junction assembly • tight junction assembly • cell-cell junction assembly • cell-cell junction organization • regulation of localization • establishment of protein localization • regulation of protein localization • protein targeting • regulation of protein targeting to mitochondrion • regulation of establishment of protein localization • positive regulation of establishment of protein localization • establishment of localization • regulation of establishment of protein localization to mitochondrion • localization • establishment of protein localization to organelle • regulation of protein targeting • macromolecule localization • protein targeting to mitochondrion • positive regulation of protein targeting to mitochondrion • intracellular protein localization • establishment of protein localization to mitochondrion • positive regulation of establishment of protein localization to mitochondrion • biological process involved in interspecies interaction between organisms • response to other organism • response to external stimulus • cellular response to molecule of bacterial origin • response to biotic stimulus • cellular response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • negative regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • Spemann organizer formation • developmental induction • regulation of tumor necrosis factor production • positive regulation of tumor necrosis factor superfamily cytokine production • tumor necrosis factor superfamily cytokine production • positive regulation of tumor necrosis factor production • tumor necrosis factor production • regulation of tumor necrosis factor superfamily cytokine production • regulation of type II interferon production • type II interferon production • positive regulation of type II interferon production • cellular anatomical structure • periplasmic space • somatodendritic compartment • cell body • perikaryon • neuronal cell body • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular organelle • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • clathrin-coated vesicle
Gene Ontology	Cellular Component	• cellular anatomical structure • periplasmic space • somatodendritic compartment • cell body • perikaryon • neuronal cell body • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular organelle • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • membrane • intracellular membrane-bounded organelle • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • organelle • cytoplasm • organelle membrane • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • Golgi membrane • Golgi apparatus • endomembrane system • perinuclear region of cytoplasm • axon • cell surface • cell periphery • plasma membrane • endosome membrane • early endosome • endosome • early endosome membrane • synapse • cell junction • cell-cell junction • apical junction complex • bicellular tight junction • tight junction • anchoring junction
SCOP2	Domain Identifier	• Cytochromes
SCOP2	Family Identifier	• Cytochromes
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q13467
Sequence	>6WW2_Chain_R R E P F V P I L K E S H P L Y N K V R T G Q V P N C A V P C Y Q P S F S A D E R T F A T F W I G L W S V L C F I S T S T T V A T F L I D M E R F R Y P E R P I I F L S A C Y L C V S L G F L V R L V V G H A S V A C S R E H N H I H Y E T T G P A L C T I V F L L V Y F F G M A S S I W W V I L S L T W F L A A G M K W G N E A I A G Y A Q Y F H L A A W L I P S V K S I T A L A L S S V D G D P V A G I C Y V G N Q N L N S L R G F V L G P L V L Y L L V G T L F L L A G F V S L F R D K L E K L M I R I G I F T L L Y T V P A S I V V A C Y L Y E Q H Y R E S W E A A L T C A C E Y W V L M L K Y F M C L V V G I T S G V W I W S G K T V E S W R R F T S R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI

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