psnGPCR

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Orange: nodes, hubs and links specific of 5ht1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	5ht1_off Int. Strength	5ht1_on Int. Strength	5ht1_off Hub1?	5ht1_on Hub1?	5ht1_off Hub2?	5ht1_on Hub2?	ConSurf1	ConSurf2
1	NT	NT	5ht1_off	36.84	0	Yes	No	Yes	No	2	2
2	7x32	NT	5ht1_off	5.34	0	No	No	Yes	No	2	2
3	7x35	NT	5ht1_off	7.06	0	No	No	Yes	No	4	2
4	1x32	NT	5ht1_off	11.43	0	No	No	Yes	No	3	2
5	2x67	NT	5ht1_off	8.22	0	No	No	Yes	No	4	2
6	1x31	1x34	5ht1_off	3.42	0	No	No	No	No	2	5
7	1x36	2x61	5ht1_off	3.17	0	No	No	No	No	6	7
8	1x43	2x58	5ht1_off	3.5	0	No	No	No	No	6	9
9	1x46	2x57	5ht1_off	9.03	0	No	No	Yes	Yes	7	7
10	1x49	7x50	5ht1_off	5.34	0	No	No	No	No	8	9
11	1x50	2x47	5ht1_off	4.69	0	No	No	No	No	9	9
12	1x52	1x56	5ht1_off	7.78	0	Yes	No	No	No	7	8
13	1x54	2x47	5ht1_off	3.25	0	No	No	No	No	7	9
14	1x56	8x50	5ht1_off	6.49	0	No	No	Yes	Yes	8	8
15	1x56	8x53	5ht1_off	3.36	0	No	No	No	No	8	8
16	2x37	2x39	5ht1_off	3.36	0	No	No	No	No	8	8
17	2x38	2x41	5ht1_off	4.17	0	No	No	No	No	6	5
18	2x39	3x50	5ht1_off	4.15	0	No	No	No	No	8	9
19	2x42	3x46	5ht1_off	4.28	0	No	No	No	No	7	9
20	2x43	7x53	5ht1_off	19.34	0	No	No	No	Yes	8	9
21	2x51	2x54	5ht1_off	4.5	0	No	No	No	No	8	7
22	2x52	3x35	5ht1_off	4.76	0	No	No	No	No	7	6
23	2x52	4x50	5ht1_off	3.42	0	No	No	Yes	No	7	9
24	2x53	2x56	5ht1_off	4.81	0	No	No	Yes	No	8	7
25	2x53	2x57	5ht1_off	4.56	0	No	No	Yes	Yes	8	7
26	2x60	3x28	5ht1_off	4.94	0	No	No	Yes	Yes	6	6
27	2x62	E1x52	5ht1_off	4.24	0	No	No	No	No	5	6
28	2x66	2x67	5ht1_off	3.64	0	No	No	No	No	5	4
29	3x24	E1x50	5ht1_off	3.68	0	No	No	Yes	Yes	4	8
30	3x26	4x61	5ht1_off	13.14	0	No	No	No	No	6	7
31	3x29	E2x50	5ht1_off	3.17	0	No	No	No	No	6	9
32	3x32	3x36	5ht1_off	4.67	0	Yes	No	No	No	8	6
33	3x37	5x461	5ht1_off	5.03	0	No	No	No	No	7	7
34	3x38	4x53	5ht1_off	3.42	0	No	No	No	No	8	8
35	3x40	5x47	5ht1_off	3.77	0	Yes	No	Yes	Yes	8	8
36	3x40	Lig	5ht1_off	4.77	0	Yes	No	Yes	Yes	8	0
37	3x41	5x49	5ht1_off	4.01	0	Yes	Yes	No	No	6	5
38	3x42	4x50	5ht1_off	5.29	0	Yes	Yes	Yes	No	7	9
39	3x44	5x54	5ht1_off	4.76	0	No	No	No	No	7	8
40	3x45	4x49	5ht1_off	3.21	0	No	No	No	No	6	7
41	3x49	3x50	5ht1_off	7.15	0	Yes	No	No	No	9	9
42	3x51	3x52	5ht1_off	4.82	0	Yes	Yes	Yes	No	8	5
43	3x52	3x56	5ht1_off	4.47	0	Yes	No	No	No	5	6
44	3x54	5x68	5ht1_off	5.01	0	No	No	No	No	9	7
45	3x55	5x60	5ht1_off	6.47	0	No	No	No	No	7	6
46	3x55	5x64	5ht1_off	5.64	0	No	No	Yes	No	7	6
47	I2x52	I2x56	5ht1_off	4.05	0	No	No	No	No	5	5
48	I2x53	I2x56	5ht1_off	8.36	0	Yes	Yes	No	No	8	5
49	4x52	4x56	5ht1_off	6.28	0	No	No	No	No	5	7
50	4x54	4x58	5ht1_off	4.28	0	No	No	No	No	4	5
51	4x63	E2	5ht1_off	7.64	0	No	No	Yes	Yes	6	4
52	5x44	Lig	5ht1_off	3.94	0	No	No	Yes	Yes	6	0
53	5x45	5x46	5ht1_off	3.68	0	No	No	No	No	3	4
54	5x48	6x52	5ht1_off	6.19	0	Yes	Yes	Yes	Yes	6	7
55	5x54	6x41	5ht1_off	4.15	0	No	No	Yes	No	8	8
56	5x58	5x62	5ht1_off	6.95	0	Yes	Yes	Yes	Yes	9	6
57	5x58	6x38	5ht1_off	5.79	0	Yes	Yes	No	No	9	6
58	5x62	6x31	5ht1_off	5.14	0	Yes	Yes	Yes	No	6	6
59	5x64	5x67	5ht1_off	4.31	0	Yes	No	No	No	6	5
60	5x64	5x68	5ht1_off	8.14	0	Yes	No	No	No	6	7
61	5x66	5x69	5ht1_off	6.26	0	No	Yes	No	Yes	6	5
62	5x66	6x31	5ht1_off	13.86	0	No	Yes	Yes	No	6	6
63	6x26	6x29	5ht1_off	21.09	0	No	No	No	No	4	7
64	6x31	6x32	5ht1_off	3.71	0	Yes	No	No	No	6	8
65	6x40	7x52	5ht1_off	5.89	0	No	No	Yes	Yes	8	8
66	6x44	6x45	5ht1_off	3.77	0	Yes	Yes	No	No	9	6
67	6x44	7x45	5ht1_off	8.46	0	Yes	Yes	Yes	No	9	9
68	6x48	7x42	5ht1_off	3.86	0	Yes	Yes	Yes	Yes	7	7
69	6x49	6x50	5ht1_off	3.28	0	Yes	No	No	No	6	9
70	6x51	7x34	5ht1_off	3.22	0	Yes	Yes	No	No	8	4
71	6x54	7x30	5ht1_off	3.98	0	No	No	No	No	4	4
72	6x58	7x30	5ht1_off	3.94	0	Yes	No	No	No	4	4
73	6x58	7x34	5ht1_off	12.44	0	Yes	No	No	No	4	4
74	6x61	7x30	5ht1_off	7.37	0	No	No	No	No	6	4
75	7x33	7x36	5ht1_off	7.54	0	No	No	No	No	4	5
76	7x37	7x40	5ht1_off	3.65	0	Yes	Yes	No	No	6	7
77	7x48	7x51	5ht1_off	4.42	0	Yes	No	No	No	6	7
78	7x53	8x50	5ht1_off	4.13	0	No	Yes	Yes	Yes	9	8
79	8x48	8x52	5ht1_off	3.82	0	No	No	No	No	6	4
80	8x55	CT	5ht1_off	16.97	0	No	No	No	No	5	6
81	3x47	5x57	5ht1_off	3.15	0	No	No	No	No	9	6
82	5x61	6x34	5ht1_off	3.04	0	No	No	No	No	9	8
83	2x62	E1x51	5ht1_off	3.01	0	No	No	No	No	5	4
84	6x55	6x56	5ht1_off	3	0	No	No	No	No	6	6
85	1x57	2x40	5ht1_off	2.96	0	No	No	No	No	8	9
86	5x58	5x59	5ht1_off	2.9	0	Yes	Yes	No	No	9	3
87	4x60	4x61	5ht1_off	2.89	0	No	No	No	No	7	7
88	3x43	6x40	5ht1_off	2.85	0	No	Yes	No	No	8	8
89	7x47	7x51	5ht1_off	2.85	0	No	No	No	No	6	7
90	2x40	2x43	5ht1_off	2.83	0	No	No	No	No	9	8
91	1x55	1x59	5ht1_off	2.77	0	No	No	No	No	4	6
92	3x50	3x53	5ht1_off	2.77	0	No	No	No	No	9	7
93	5x65	6x31	5ht1_off	2.77	0	No	No	Yes	No	8	6
94	1x52	7x54	5ht1_off	2.59	0	Yes	No	No	No	7	7
95	5x60	5x61	5ht1_off	2.51	0	No	No	No	No	6	9
96	8x58	CT	5ht1_off	2.51	0	No	No	No	No	6	6
97	1x52	8x57	5ht1_off	2.44	0	Yes	No	No	No	7	6
98	6x57	6x61	5ht1_off	1.71	0	No	No	No	No	5	6
99	6x43	7x48	5ht1_off	1.62	0	No	No	Yes	No	6	6
100	6x28	6x32	5ht1_off	1.61	0	No	No	No	No	5	8
101	7x52	7x56	5ht1_off	1.55	0	Yes	Yes	No	No	8	7
102	4x40	4x44	5ht1_off	1.52	0	No	No	No	No	5	3
103	6x30	6x33	5ht1_off	1.51	0	No	Yes	No	No	8	8
104	2x67	E1x49	5ht1_off	1.5	0	No	No	No	No	4	3
105	4x55	4x58	5ht1_off	1.5	0	No	No	No	No	4	5
106	1x35	2x65	5ht1_off	1.49	0	No	No	No	No	4	6
107	5x37	5x38	5ht1_off	1.43	0	No	No	No	No	3	3
108	5x52	5x55	5ht1_off	1.43	0	No	No	No	No	3	5
109	6x37	6x40	5ht1_off	1.43	0	No	No	No	No	8	8
110	1x29	1x32	5ht1_off	1.41	0	No	No	No	No	3	3
111	1x34	1x37	5ht1_off	1.41	0	No	No	No	No	5	4
112	6x30	6x34	5ht1_off	1.41	0	No	Yes	No	No	8	8
113	6x58	7x31	5ht1_off	1.41	0	Yes	No	No	No	4	2
114	1x35	1x38	5ht1_off	1.38	0	No	No	No	No	4	5
115	1x30	1x31	5ht1_off	1.35	0	No	No	No	No	3	2
116	5x62	5x63	5ht1_off	1.26	0	Yes	Yes	No	No	6	4
117	3x26	3x27	5ht1_off	1.19	0	No	No	No	No	6	5
118	5x58	6x35	5ht1_off	1.19	0	Yes	Yes	No	No	9	8
119	1x58	1x59	5ht1_off	1.03	0	No	No	No	No	3	6
120	5x40	Lig	5ht1_off	0.98	0	No	No	Yes	Yes	6	0
121	1x29	1x30	Shared	3.28	0.664	No	No	No	No	3	3
122	1x32	2x65	Shared	4.55	1.7015	No	No	No	No	3	6
123	1x36	2x65	Shared	4.81	2.7405	No	No	No	No	6	6
124	1x39	2x61	Shared	5.9	4.587	No	Yes	No	No	6	7
125	1x39	7x39	Shared	26.19	16.343	No	Yes	Yes	Yes	6	6
126	1x43	2x57	Shared	10.54	6.904	No	No	Yes	Yes	6	7
127	1x45	7x47	Shared	4.73	3.386	No	No	No	No	5	6
128	1x46	2x54	Shared	6.4	2.956	No	No	No	No	7	7
129	1x46	7x47	Shared	4.42	8.2175	No	No	No	No	7	6
130	1x47	2x54	Shared	7.99	4.383	No	No	No	No	6	7
131	1x50	2x50	Shared	6.73	8.1445	No	No	Yes	Yes	9	9
132	1x50	7x50	Shared	13.03	6.2755	No	No	No	No	9	9
133	1x52	8x54	Shared	5.36	4.053	Yes	No	No	Yes	7	7
134	1x53	2x47	Shared	3.39	2.714	No	No	No	No	9	9
135	1x54	2x48	Shared	4.61	3.982	No	No	No	No	7	6
136	1x60	I1x50	Shared	10.32	7.4145	No	Yes	No	Yes	7	8
137	I1x48	I1x51	Shared	5.64	2.257	No	No	No	No	6	8
138	8x49	I1x50	Shared	4.07	3.517	No	No	No	Yes	6	8
139	2x41	I1x51	Shared	4.36	6.5225	No	No	No	No	5	8
140	2x37	2x40	Shared	7.31	8.297	No	No	No	No	8	9
141	2x38	I2x57	Shared	4.32	4.7515	No	No	No	Yes	6	7
142	2x38	4x39	Shared	9.74	2.176	No	No	No	No	6	3
143	2x41	4x39	Shared	4.17	3.292	No	No	No	No	5	3
144	2x42	3x49	Shared	4.07	3.936	No	No	Yes	No	7	9
145	2x45	3x42	Shared	12.55	8.6455	No	No	Yes	Yes	9	7
146	2x45	4x46	Shared	9.29	9.755	No	No	No	No	9	7
147	2x46	2x50	Shared	4.07	4.0025	No	Yes	Yes	Yes	9	9
148	2x46	3x43	Shared	4.15	4.4315	No	Yes	No	Yes	9	8
149	2x49	3x38	Shared	3.36	3.834	No	No	No	No	8	8
150	2x49	3x42	Shared	5.48	6.436	No	No	Yes	Yes	8	7
151	2x49	4x50	Shared	10.92	4.3055	No	No	Yes	No	8	9
152	2x50	7x46	Shared	8.83	8.3195	Yes	Yes	No	No	9	9
153	2x50	7x49	Shared	6.73	5.3855	Yes	Yes	No	Yes	9	9
154	2x52	2x551	Shared	4.15	2.357	No	No	No	No	7	5
155	2x53	7x46	Shared	8.08	4.6865	No	No	No	No	8	9
156	2x551	3x31	Shared	4.5	3.2915	No	No	No	No	5	5
157	2x56	3x28	Shared	4.9	4.69	Yes	No	Yes	Yes	7	6
158	2x56	3x32	Shared	13.15	7.74	Yes	No	Yes	No	7	8
159	2x56	7x42	Shared	5.05	4.354	Yes	No	Yes	Yes	7	7
160	2x57	7x39	Shared	5.82	4.711	Yes	Yes	Yes	Yes	7	6
161	2x59	3x28	Shared	14.09	12.669	No	No	Yes	Yes	6	6
162	2x60	7x39	Shared	8.65	5.4495	No	No	Yes	Yes	6	6
163	2x60	7x42	Shared	6.36	4.8035	No	No	Yes	Yes	6	7
164	2x61	7x39	Shared	4.85	4.576	No	No	Yes	Yes	7	6
165	2x63	E1x50	Shared	8.68	6.848	No	No	Yes	Yes	6	8
166	2x63	E2	Shared	5.61	4.2255	No	No	Yes	Yes	6	4
167	2x64	7x39	Shared	9.7	4.319	No	No	Yes	Yes	5	6
168	E1x50	E1x52	Shared	12.53	6.342	Yes	Yes	No	No	8	6
169	3x25	E1x50	Shared	5.22	5.6155	No	No	Yes	Yes	9	8
170	3x28	E1x50	Shared	10.31	6.513	Yes	Yes	Yes	Yes	6	8
171	E1x50	E2x50	Shared	15.67	12.4055	Yes	Yes	No	No	8	9
172	3x24	E1x52	Shared	7.45	8.837	No	No	No	No	4	6
173	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
174	3x28	3x29	Shared	4.56	3.316	Yes	Yes	No	No	6	6
175	3x30	4x57	Shared	6.52	2.0415	No	No	No	No	7	7
176	3x32	7x42	Shared	11.49	10.114	Yes	No	Yes	Yes	8	7
177	3x32	Lig	Shared	11.78	11.725	Yes	No	Yes	Yes	8	0
178	3x33	Lig	Shared	4.77	9.5835	No	No	Yes	Yes	6	0
179	3x34	4x53	Shared	3.2	3.6275	No	No	No	No	6	8
180	3x34	4x57	Shared	4.8	4.814	No	No	No	No	6	7
181	3x36	6x48	Shared	3.92	5.288	No	No	Yes	Yes	6	7
182	3x36	Lig	Shared	5.3	9.455	No	No	Yes	Yes	6	0
183	3x37	4x53	Shared	6.4	5.117	No	No	No	No	7	8
184	3x37	Lig	Shared	4.92	3.5485	No	No	Yes	Yes	7	0
185	3x38	4x50	Shared	5.19	10.6595	No	No	Yes	No	8	9
186	3x40	5x50	Shared	5.08	3.305	Yes	No	No	No	8	9
187	3x40	6x44	Shared	11.3	4.27	Yes	No	Yes	Yes	8	9
188	3x41	3x44	Shared	5.22	3.5925	Yes	Yes	No	No	6	7
189	3x41	4x49	Shared	3.68	3.832	Yes	Yes	No	No	6	7
190	3x41	4x52	Shared	14.03	9.997	Yes	Yes	No	No	6	5
191	3x41	5x50	Shared	13.51	5.5295	Yes	Yes	No	No	6	9
192	3x42	4x46	Shared	7.95	5.6345	Yes	Yes	No	No	7	7
193	3x42	4x49	Shared	13.84	8.903	Yes	Yes	No	No	7	7
194	3x43	6x44	Shared	3.65	3.4715	No	Yes	Yes	Yes	8	9
195	3x44	5x53	Shared	3.17	3.7905	No	No	No	No	7	7
196	3x45	4x45	Shared	9.13	4.161	No	No	No	No	6	6
197	3x48	3x52	Shared	17.08	12.0435	No	No	Yes	No	6	5
198	3x49	I2x53	Shared	9.2	7.128	Yes	No	Yes	Yes	9	8
199	3x49	I2x57	Shared	10.72	8.456	Yes	No	No	Yes	9	7
200	3x51	3x55	Shared	3.75	12.8595	Yes	Yes	No	No	8	7
201	3x51	5x57	Shared	3.52	6.035	Yes	Yes	No	No	8	6
202	3x51	5x60	Shared	12.35	11.6015	Yes	Yes	No	No	8	6
203	3x52	I2x53	Shared	18.33	13.914	Yes	No	Yes	Yes	5	8
204	3x54	5x64	Shared	4.1	1.842	No	No	Yes	No	9	6
205	3x56	I2x52	Shared	6.5	5.0505	No	No	No	No	6	5
206	I2x53	I2x57	Shared	17.49	12.8115	Yes	Yes	No	Yes	8	7
207	4x38	4x39	Shared	5.25	2.5375	No	No	No	No	8	3
208	4x38	4x40	Shared	4.5	1.352	No	No	No	No	8	5
209	4x59	4x60	Shared	5.84	5.84	No	No	No	No	7	7
210	4x59	5x39	Shared	5.56	3.7005	No	No	No	Yes	7	8
211	4x63	5x36	Shared	14.81	3.286	No	No	No	Yes	6	6
212	E2	E2	Shared	15.81	8.333	Yes	Yes	Yes	Yes	4	4
213	E2	E2x51	Shared	4.28	6.377	Yes	Yes	No	No	4	3
214	E2x52	Lig	Shared	3.98	5.3235	No	No	Yes	Yes	6	0
215	5x44	5x48	Shared	6.24	3.9965	No	No	Yes	Yes	6	6
216	5x45	5x48	Shared	6.31	3.7355	No	No	Yes	Yes	3	6
217	5x47	5x48	Shared	11.35	5.879	Yes	Yes	Yes	Yes	8	6
218	5x47	5x51	Shared	7.78	8.8475	Yes	Yes	No	No	8	6
219	5x47	6x49	Shared	3.65	6.271	Yes	Yes	Yes	No	8	6
220	5x47	6x52	Shared	33.22	21.111	Yes	Yes	Yes	Yes	8	7
221	5x48	6x56	Shared	4.69	5.0995	Yes	Yes	No	No	6	6
222	5x49	5x50	Shared	5.78	4.254	No	No	No	No	5	9
223	5x51	6x44	Shared	5.19	3.336	No	No	Yes	Yes	6	9
224	5x53	5x57	Shared	5.54	3.666	No	No	No	No	7	6
225	5x55	6x41	Shared	5.71	3.517	No	No	Yes	No	5	8
226	5x58	6x41	Shared	3.52	3.1765	Yes	Yes	Yes	No	9	8
227	5x62	5x66	Shared	4.12	6.9955	Yes	Yes	No	Yes	6	6
228	6x36	7x56	Shared	7.99	7.646	No	No	No	No	8	7
229	6x45	6x49	Shared	4.28	3.591	No	No	Yes	No	6	6
230	6x47	7x45	Shared	9.45	7.316	No	No	Yes	No	7	9
231	6x48	6x51	Shared	9.02	4.409	Yes	Yes	Yes	Yes	7	8
232	6x48	6x52	Shared	6.01	8.067	Yes	Yes	Yes	Yes	7	7
233	6x48	7x41	Shared	12.67	7.8775	Yes	Yes	No	No	7	7
234	6x48	7x45	Shared	3.39	10.17	Yes	Yes	Yes	No	7	9
235	6x48	Lig	Shared	17.49	4.132	Yes	Yes	Yes	Yes	7	0
236	6x49	6x53	Shared	7.14	2.926	Yes	No	No	No	6	6
237	6x50	7x37	Shared	10.11	5.1255	No	No	Yes	Yes	9	6
238	6x51	6x52	Shared	10.72	3.3785	Yes	Yes	Yes	Yes	8	7
239	6x51	7x38	Shared	7.78	4.53	Yes	Yes	No	No	8	6
240	6x51	Lig	Shared	15.45	12.7125	Yes	Yes	Yes	Yes	8	0
241	6x52	Lig	Shared	13.83	9.5175	Yes	Yes	Yes	Yes	7	0
242	6x54	7x34	Shared	5.02	2.948	No	No	No	No	4	4
243	6x54	7x37	Shared	3.77	4.4355	No	No	Yes	Yes	4	6
244	6x58	6x59	Shared	3.35	2.838	Yes	No	No	No	4	5
245	7x36	7x37	Shared	7.5	3.178	No	No	Yes	Yes	5	6
246	7x38	7x42	Shared	6.24	3.7115	No	No	Yes	Yes	6	7
247	7x39	7x42	Shared	6.75	6.7035	Yes	Yes	Yes	Yes	6	7
248	7x42	Lig	Shared	4.7	5.911	Yes	Yes	Yes	Yes	7	0
249	7x43	7x48	Shared	5.71	3.501	No	No	Yes	No	4	6
250	7x45	7x49	Shared	13.62	11.7825	Yes	No	No	Yes	9	9
251	8x47	8x49	Shared	10.77	11.106	No	No	No	No	9	6
252	8x47	8x50	Shared	7.25	6.0995	No	No	Yes	Yes	9	8
253	8x48	8x51	Shared	9.45	2.2485	No	No	No	No	6	9
254	8x51	8x55	Shared	3.93	0.262	No	No	No	No	9	5
255	2x42	4x42	Shared	3.15	2.1275	No	No	No	No	7	7
256	4x41	I2x53	Shared	3.09	4.054	No	No	Yes	Yes	6	8
257	3x34	4x54	Shared	3.04	3.469	No	No	No	No	6	4
258	5x43	Lig	Shared	3.01	5.153	No	No	Yes	Yes	7	0
259	1x60	I1x49	Shared	3	3.1925	No	Yes	No	No	7	6
260	4x44	4x48	Shared	2.98	1.2	No	No	No	No	3	2
261	2x50	3x39	Shared	2.94	3.605	Yes	Yes	No	No	9	9
262	7x48	7x52	Shared	2.94	3.2815	Yes	No	Yes	Yes	6	8
263	2x51	2x55	Shared	2.85	3.3555	No	No	No	No	8	5
264	2x55	2x551	Shared	2.85	3.3005	No	No	No	No	5	5
265	3x21	E1x50	Shared	2.81	1.4775	No	No	Yes	Yes	6	8
266	3x30	4x61	Shared	2.64	2.0075	No	No	No	No	7	7
267	3x23	3x27	Shared	2.62	2.096	No	No	No	No	1	5
268	7x54	8x50	Shared	2.59	11.934	No	No	Yes	Yes	7	8
269	7x54	8x54	Shared	2.59	3.632	No	No	No	Yes	7	7
270	5x36	5x38	Shared	2.57	1.668	No	Yes	No	No	6	3
271	4x56	5x42	Shared	2.42	2.3565	No	No	No	No	7	4
272	1x42	7x39	Shared	2.35	1.956	No	No	Yes	Yes	6	6
273	1x28	1x30	Shared	1.78	1.068	No	No	No	No	6	3
274	6x41	6x42	Shared	1.71	1.718	Yes	No	No	No	8	6
275	1x57	2x44	Shared	1.7	4.7565	No	No	No	No	8	6
276	5x69	6x27	Shared	1.62	0.87	No	Yes	No	No	5	5
277	6x43	7x52	Shared	1.62	2.602	No	No	Yes	Yes	6	8
278	5x41	5x45	Shared	1.6	3.6685	No	No	No	No	5	3
279	1x48	1x49	Shared	1.5	0.95	No	No	No	No	4	8
280	1x29	1x33	Shared	1.49	0.59	No	No	No	No	3	5
281	6x39	7x52	Shared	1.47	3.83	No	No	Yes	Yes	7	8
282	8x54	8x58	Shared	1.26	1.256	No	Yes	No	No	7	6
283	1x35	1x39	5ht1_on	0	3.4505	No	No	No	Yes	4	6
284	1x50	2x51	5ht1_on	0	4.982	No	No	No	No	9	8
285	1x53	7x54	5ht1_on	0	3.216	No	No	No	No	9	7
286	1x56	8x54	5ht1_on	0	3.9445	No	No	No	Yes	8	7
287	1x57	8x50	5ht1_on	0	4.457	No	No	Yes	Yes	8	8
288	1x60	8x53	5ht1_on	0	4.186	No	Yes	No	No	7	8
289	2x40	I1x50	5ht1_on	0	5.22	No	No	No	Yes	9	8
290	8x50	I1x50	5ht1_on	0	7.794	Yes	Yes	No	Yes	8	8
291	2x40	8x50	5ht1_on	0	5.0745	No	No	Yes	Yes	9	8
292	2x46	3x42	5ht1_on	0	4.884	No	Yes	Yes	Yes	9	7
293	2x46	3x46	5ht1_on	0	3.495	No	Yes	No	No	9	9
294	2x46	7x49	5ht1_on	0	6.042	No	Yes	No	Yes	9	9
295	2x53	3x35	5ht1_on	0	3.2465	No	No	No	No	8	6
296	2x57	7x42	5ht1_on	0	5.004	Yes	Yes	Yes	Yes	7	7
297	2x64	7x35	5ht1_on	0	4.023	No	No	No	No	5	4
298	E1x49	E2	5ht1_on	0	4.2235	No	No	Yes	Yes	3	4
299	3x22	3x26	5ht1_on	0	3.916	No	No	No	No	4	6
300	3x29	E2x52	5ht1_on	0	3.621	No	No	No	No	6	6
301	3x33	4x57	5ht1_on	0	5.829	No	No	No	No	6	7
302	3x37	4x56	5ht1_on	0	4.94	No	No	No	No	7	7
303	3x38	3x42	5ht1_on	0	4.072	No	No	Yes	Yes	8	7
304	3x40	6x48	5ht1_on	0	6.9875	Yes	No	Yes	Yes	8	7
305	3x43	7x49	5ht1_on	0	10.4335	No	Yes	No	Yes	8	9
306	3x43	7x53	5ht1_on	0	7.149	No	Yes	No	Yes	8	9
307	3x46	3x50	5ht1_on	0	5.9495	No	No	No	No	9	9
308	3x46	7x53	5ht1_on	0	5.3775	No	No	No	Yes	9	9
309	3x47	5x58	5ht1_on	0	3.8025	No	No	Yes	Yes	9	9
310	3x48	5x57	5ht1_on	0	5.191	No	No	No	No	6	6
311	3x50	5x58	5ht1_on	0	4.319	No	No	Yes	Yes	9	9
312	3x50	7x53	5ht1_on	0	7.8185	No	No	No	Yes	9	9
313	3x51	5x61	5ht1_on	0	3.6905	Yes	Yes	No	No	8	9
314	3x55	3x56	5ht1_on	0	4.8445	No	No	No	No	7	6
315	4x58	4x59	5ht1_on	0	3.7725	No	No	No	No	5	7
316	4x60	5x39	5ht1_on	0	6.608	No	No	No	Yes	7	8
317	5x36	E2	5ht1_on	0	9.42	No	Yes	Yes	Yes	6	4
318	6x59	E2	5ht1_on	0	3.246	No	No	Yes	Yes	5	4
319	5x36	5x39	5ht1_on	0	7.42	No	Yes	No	Yes	6	8
320	5x37	6x60	5ht1_on	0	3.626	No	No	No	No	3	6
321	5x39	5x43	5ht1_on	0	3.688	No	Yes	No	No	8	7
322	5x44	6x52	5ht1_on	0	3.2445	No	No	Yes	Yes	6	7
323	5x44	6x56	5ht1_on	0	5.159	No	No	No	No	6	6
324	5x461	Lig	5ht1_on	0	3.259	No	No	Yes	Yes	7	0
325	5x47	6x44	5ht1_on	0	7.074	Yes	Yes	Yes	Yes	8	9
326	5x47	6x48	5ht1_on	0	3.258	Yes	Yes	Yes	Yes	8	7
327	5x54	5x58	5ht1_on	0	4.117	No	No	Yes	Yes	8	9
328	5x56	5x60	5ht1_on	0	3.9615	No	No	No	No	4	6
329	5x58	6x37	5ht1_on	0	4.5685	Yes	Yes	No	No	9	8
330	5x58	6x40	5ht1_on	0	8.887	Yes	Yes	No	No	9	8
331	5x62	6x34	5ht1_on	0	4.8915	Yes	Yes	No	No	6	8
332	5x62	6x37	5ht1_on	0	5.603	Yes	Yes	No	No	6	8
333	5x66	5x70	5ht1_on	0	3.468	No	Yes	No	No	6	0
334	5x66	6x30	5ht1_on	0	7.2405	No	Yes	No	Yes	6	8
335	5x70	6x30	5ht1_on	0	4.33	No	No	No	Yes	0	8
336	6x40	7x53	5ht1_on	0	4.112	No	No	No	Yes	8	9
337	6x44	6x48	5ht1_on	0	5.664	Yes	Yes	Yes	Yes	9	7
338	6x58	E3	5ht1_on	0	3.2645	Yes	No	No	Yes	4	4
339	E3	E3	5ht1_on	0	4.486	No	Yes	No	Yes	4	4
340	7x52	7x53	5ht1_on	0	3.9815	Yes	Yes	No	Yes	8	9
341	8x50	8x54	5ht1_on	0	6.376	Yes	Yes	No	Yes	8	7
342	1x44	1x48	5ht1_on	0	3.233	No	No	No	No	5	4
343	4x41	I2x56	5ht1_on	0	4.208	No	No	No	No	6	5
344	4x41	4x45	5ht1_on	0	3.5815	No	No	No	No	6	6
345	4x51	4x55	5ht1_on	0	3.169	No	No	No	No	4	4
346	6x32	6x36	5ht1_on	0	5.083	No	No	No	No	8	8
347	6x55	Lig	5ht1_on	0	7.5395	No	No	Yes	Yes	6	0
348	7x33	7x37	5ht1_on	0	3.8925	No	No	Yes	Yes	4	6
349	E1x49	E1x51	5ht1_on	0	7.1535	No	No	No	No	3	4
350	5x62	6x30	5ht1_on	0	4.049	Yes	Yes	No	Yes	6	8
351	5x69	6x30	5ht1_on	0	4.343	No	Yes	No	Yes	5	8
352	8x49	I1x49	5ht1_on	0	3.32	No	No	No	No	6	6
353	3x26	4x63	5ht1_on	0	5.584	No	No	No	No	6	6
354	4x62	E2	5ht1_on	0	4.198	No	No	Yes	Yes	6	4
355	7x31	7x35	5ht1_on	0	3.242	No	No	No	No	2	4
356	I3	I3	5ht1_on	0	4.494	No	Yes	No	Yes	0	0
357	7x55	7x56	5ht1_on	0	3.344	No	No	No	No	5	7
358	3x54	5x61	5ht1_on	0	3.165	No	No	No	No	9	9
359	6x51	6x54	5ht1_on	0	2.978	Yes	Yes	No	No	8	4
360	5x40	6x59	5ht1_on	0	2.972	No	No	No	No	6	5
361	2x39	I2x57	5ht1_on	0	2.904	No	No	No	Yes	8	7
362	2x54	2x57	5ht1_on	0	2.867	No	No	Yes	Yes	7	7
363	6x25	6x29	5ht1_on	0	2.807	No	No	No	No	0	7
364	8x47	8x48	5ht1_on	0	2.698	No	No	No	No	9	6
365	2x37	2x38	5ht1_on	0	2.642	No	No	No	No	8	6
366	7x30	7x33	5ht1_on	0	2.6015	No	No	No	No	4	4
367	1x60	8x56	5ht1_on	0	2.582	No	Yes	No	No	7	5
368	I2x51	I2x52	5ht1_on	0	2.544	No	No	No	No	6	5
369	1x28	1x31	5ht1_on	0	2.53	No	No	No	No	6	2
370	5x46	5x49	5ht1_on	0	2.47	No	No	No	No	4	5
371	2x43	8x50	5ht1_on	0	2.4485	No	No	Yes	Yes	8	8
372	6x31	6x35	5ht1_on	0	2.416	Yes	No	No	No	6	8
373	6x50	7x40	5ht1_on	0	2.38	No	No	No	No	9	7
374	2x65	2x66	5ht1_on	0	2.2815	No	No	No	No	6	5
375	3x53	I2x57	5ht1_on	0	2.281	No	No	No	Yes	7	7
376	7x55	8x51	5ht1_on	0	2.278	No	No	No	No	5	9
377	6x61	E3	5ht1_on	0	2.2355	No	No	No	Yes	6	4
378	6x57	E3	5ht1_on	0	2.2315	No	No	No	Yes	5	4
379	5x41	6x60	5ht1_on	0	2.2235	No	No	No	No	5	6
380	1x56	8x57	5ht1_on	0	2.211	No	No	No	No	8	6
381	2x66	E1x49	5ht1_on	0	2.051	No	No	No	No	5	3
382	1x33	1x37	5ht1_on	0	1.9635	No	No	No	No	5	4
383	1x59	8x57	5ht1_on	0	1.741	No	No	No	No	6	6
384	5x68	5x72	5ht1_on	0	1.73	No	No	No	No	7	0
385	5x63	5x66	5ht1_on	0	1.683	No	No	No	Yes	4	6
386	2x57	2x58	5ht1_on	0	1.672	Yes	Yes	No	No	7	9
387	1x45	1x49	5ht1_on	0	1.66	No	No	No	No	5	8
388	1x54	2x44	5ht1_on	0	1.65	No	No	No	No	7	6
389	5x73	I3	5ht1_on	0	1.642	No	No	No	Yes	0	0
390	4x48	4x52	5ht1_on	0	1.633	No	No	No	No	2	5
391	I2x51	I2x55	5ht1_on	0	1.5685	No	No	No	No	6	5
392	6x35	6x39	5ht1_on	0	1.5265	No	No	No	No	8	7
393	1x40	1x44	5ht1_on	0	1.518	No	No	No	No	3	5
394	1x38	1x39	5ht1_on	0	1.48	No	No	No	Yes	5	6
395	1x55	8x57	5ht1_on	0	1.478	No	No	No	No	4	6
396	5x67	5x70	5ht1_on	0	1.37	No	No	No	No	5	0
397	6x20	6x23	5ht1_on	0	1.279	No	Yes	No	No	0	0
398	5x59	5x63	5ht1_on	0	1.234	No	No	No	No	3	4
399	2x62	2x66	5ht1_on	0	1.2015	No	No	No	No	5	5
400	1x54	1x58	5ht1_on	0	1.108	No	No	No	No	7	3
401	7x51	7x55	5ht1_on	0	1.1045	No	No	No	No	7	5
402	5x68	I3	5ht1_on	0	1.028	No	No	No	Yes	7	0
403	2x67	7x35	5ht1_on	0	1.008	No	No	No	No	4	4
404	1x41	1x44	5ht1_on	0	1.002	No	No	No	No	4	5
405	5x69	6x29	5ht1_on	0	1.0015	No	Yes	No	No	5	7
406	1x29	NT	5ht1_on	0	0.992	No	No	Yes	No	3	2
407	7x30	7x32	5ht1_on	0	0.956	No	No	No	No	4	2
408	5x69	6x26	5ht1_on	0	0.9445	No	Yes	No	No	5	4
409	3x27	3x30	5ht1_on	0	0.928	No	No	No	No	5	7
410	I2x54	I2x55	5ht1_on	0	0.9235	No	No	No	No	6	5
411	4x64	E2	5ht1_on	0	0.9215	No	No	Yes	Yes	0	4
412	1x34	1x35	5ht1_on	0	0.894	No	No	No	No	5	4
413	8x52	8x56	5ht1_on	0	0.884	No	No	No	No	4	5
414	6x37	6x38	5ht1_on	0	0.855	No	No	No	No	8	6
415	1x51	1x55	5ht1_on	0	0.848	No	No	No	No	4	4
416	5x52	5x56	5ht1_on	0	0.8315	No	No	No	No	3	4
417	6x19	6x23	5ht1_on	0	0.761	No	No	No	No	0	0
418	5x67	5x71	5ht1_on	0	0.744	No	No	No	No	5	0
419	1x31	1x32	5ht1_on	0	0.6765	No	No	No	No	2	3
420	6x26	6x28	5ht1_on	0	0.64	No	No	No	No	4	5
421	4x44	4x47	5ht1_on	0	0.608	No	No	No	No	3	3
422	4x47	4x48	5ht1_on	0	0.608	No	No	No	No	3	2
423	5x62	6x33	5ht1_on	0	0.5905	Yes	Yes	No	No	6	8
424	4x55	5x42	5ht1_on	0	0.5605	No	No	No	No	4	4
425	5x67	5x68	5ht1_on	0	0.535	No	No	No	No	5	7
426	4x65	E2	5ht1_on	0	0.494	No	No	Yes	Yes	0	4
427	I2x50	I2x51	5ht1_on	0	0.4935	No	No	No	No	8	6
428	4x40	4x43	5ht1_on	0	0.459	No	No	No	No	5	3
429	6x42	6x46	5ht1_on	0	0.352	No	No	No	No	6	5
430	6x18	6x22	5ht1_on	0	0.35	No	No	No	No	0	0
431	6x14	6x15	5ht1_on	0	0.3495	No	No	No	No	0	0
432	6x15	6x18	5ht1_on	0	0.3405	No	No	No	No	0	0
433	5x65	6x33	5ht1_on	0	0.336	No	No	No	No	8	8
434	6x15	6x16	5ht1_on	0	0.197	No	No	No	No	0	0
435	6x16	6x20	5ht1_on	0	0.1905	No	No	No	Yes	0	0
436	6x22	6x25	5ht1_on	0	0.144	No	No	No	No	0	0
437	6x16	6x17	5ht1_on	0	0.1165	No	No	No	No	0	0
438	6x17	6x20	5ht1_on	0	0.1165	No	No	No	Yes	0	0
439	6x21	6x24	5ht1_on	0	0.0805	No	No	No	No	0	0
440	6x20	6x24	5ht1_on	0	0.0675	No	Yes	No	No	0	0

Orange: nodes, hubs and links specific of 5ht1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	5ht1_off Avg Int. Strength	5ht1_on Avg Int. Strength	5ht1_off Num Of Links	5ht1_on Num Of Links	ConSurf
1	NT	5ht1_off	17.6217	0.992	6	1	2
2	1x52	5ht1_off	4.5425	4.053	4	1	7
3	2x56	5ht1_off	6.9775	5.59467	4	3	7
4	3x32	5ht1_off	10.2725	9.85967	4	3	8
5	3x40	5ht1_off	6.23	4.85417	4	3	8
6	3x49	5ht1_off	7.785	6.50667	4	3	9
7	3x52	5ht1_off	11.175	12.9788	4	2	5
8	4x50	5ht1_off	6.205	7.4825	4	2	9
9	5x64	5ht1_off	5.5475	1.842	4	1	6
10	6x31	5ht1_off	6.37	2.416	4	1	6
11	6x41	5ht1_off	3.7725	2.80383	4	3	8
12	6x49	5ht1_off	4.5875	4.26267	4	3	6
13	6x58	5ht1_off	5.285	3.05125	4	2	4
14	7x45	5ht1_off	8.73	9.75617	4	3	9
15	7x48	5ht1_off	3.6725	3.39125	4	2	6
16	2x50	Shared	5.86	5.8914	5	5	9
17	2x57	Shared	7.4875	4.2316	4	5	7
18	E1x50	Shared	8.41429	6.53358	7	6	8
19	3x28	Shared	7.76	6.797	5	4	6
20	3x41	Shared	8.09	5.73775	5	4	6
21	3x42	Shared	9.022	6.42917	5	6	7
22	3x51	Shared	6.11	8.54663	4	4	8
23	I2x53	Shared	11.294	9.47688	5	4	8
24	E2	Shared	9.83	4.97715	5	10	4
25	5x47	Shared	11.954	8.74008	5	6	8
26	5x48	Shared	6.956	4.67763	5	4	6
27	5x58	Shared	4.07	4.81175	5	6	9
28	5x62	Shared	4.3675	4.4259	4	5	6
29	6x44	Shared	6.474	4.7631	5	5	9
30	6x48	Shared	8.05143	6.20589	7	9	7
31	6x51	Shared	9.238	5.6016	5	5	8
32	6x52	Shared	13.994	9.0637	5	5	7
33	7x37	Shared	6.2575	4.15788	4	4	6
34	7x39	Shared	9.18714	6.294	7	7	6
35	7x42	Shared	6.35	5.80021	7	7	7
36	7x52	Shared	2.694	3.42375	5	4	8
37	8x50	Shared	5.115	6.31193	4	7	8
38	Lig	Shared	7.30154	7.32167	13	12	0
39	1x39	5ht1_on	16.045	6.46513	2	4	6
40	1x60	5ht1_on	6.66	4.34375	2	4	7
41	I1x50	5ht1_on	7.195	5.98637	2	4	8
42	2x46	5ht1_on	4.11	4.571	2	5	9
43	3x43	5ht1_on	3.55	6.37138	3	4	8
44	I2x57	5ht1_on	10.8433	6.2408	3	5	7
45	5x36	5ht1_on	8.69	5.4485	2	4	6
46	5x39	5ht1_on	5.56	5.35413	1	4	8
47	5x66	5ht1_on	8.08	4.84675	3	4	6
48	5x69	5ht1_on	3.94	1.78975	2	4	5
49	6x20	5ht1_on	0	0.413375	0	4	0
50	6x30	5ht1_on	1.46	4.99063	2	4	8
51	E3	5ht1_on	0	3.3407	0	5	4
52	7x49	5ht1_on	10.175	8.41088	2	4	9
53	7x53	5ht1_on	11.735	5.6877	2	5	9
54	8x54	5ht1_on	3.07	3.8523	3	5	7
55	I3	5ht1_on	0	2.9145	0	4	0

Orange: nodes, hubs and links specific of 5ht1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	5ht1_off Recurrence	5ht1_on Recurrence	5ht1_off Hub1?	5ht1_on Hub1?	5ht1_off Hub2?	5ht1_on Hub2?	ConSurf1	ConSurf2
1	1x29	1x32	5ht1_off	10.8152	0	No	No	No	No	3	3
2	1x36	2x65	5ht1_off	25.0793	1.20606	No	No	No	No	6	6
3	1x36	2x61	5ht1_off	26.3129	0	No	No	No	No	6	7
4	2x61	7x39	5ht1_off	27.4709	1.214	No	No	Yes	Yes	7	6
5	2x57	7x39	5ht1_off	16.3486	0.591129	Yes	Yes	Yes	Yes	7	6
6	1x46	2x57	5ht1_off	13.7606	0	No	No	Yes	Yes	7	7
7	1x50	2x50	5ht1_off	14.3749	9.8548	No	No	Yes	Yes	9	9
8	7x53	8x50	5ht1_off	30.1596	0	No	Yes	Yes	Yes	9	8
9	2x43	7x53	5ht1_off	31.3781	0	No	No	No	Yes	8	9
10	2x40	2x43	5ht1_off	32.8433	0	No	No	No	No	9	8
11	2x37	2x39	5ht1_off	38.5026	0	No	No	No	No	8	8
12	2x39	3x50	5ht1_off	39.6657	0	No	No	No	No	8	9
13	3x49	3x50	5ht1_off	42.44	0	Yes	No	No	No	9	9
14	3x49	I2x53	5ht1_off	45.7782	3.41982	Yes	No	Yes	Yes	9	8
15	3x51	3x52	5ht1_off	68.1184	0	Yes	Yes	Yes	No	8	5
16	3x40	Lig	5ht1_off	73.4454	0	Yes	No	Yes	Yes	8	0
17	7x54	8x50	5ht1_off	15.1352	3.92367	No	No	Yes	Yes	7	8
18	7x54	8x54	5ht1_off	10.6389	0.0912481	No	No	No	Yes	7	7
19	3x38	4x53	5ht1_off	22.305	0	No	No	No	No	8	8
20	3x37	4x53	5ht1_off	27.1839	4.5386	No	No	No	No	7	8
21	3x42	4x50	5ht1_off	13.4938	0	Yes	Yes	Yes	No	7	9
22	3x38	4x50	5ht1_off	12.7335	1.77339	No	No	Yes	No	8	9
23	3x40	6x44	5ht1_off	27.0832	9.32318	Yes	No	Yes	Yes	8	9
24	6x44	7x45	5ht1_off	11.8423	0	Yes	Yes	Yes	No	9	9
25	6x48	7x42	5ht1_off	15.825	0	Yes	Yes	Yes	Yes	7	7
26	2x60	3x28	5ht1_off	26.1568	0	No	No	Yes	Yes	6	6
27	E1x50	E1x52	5ht1_off	11.4596	7.53392	Yes	Yes	No	No	8	6
28	2x63	E1x50	5ht1_off	25.4519	7.62517	No	No	Yes	Yes	6	8
29	2x63	E2	5ht1_off	21.6656	4.97897	No	No	Yes	Yes	6	4
30	3x30	4x61	5ht1_off	15.9307	1.52741	No	No	No	No	7	7
31	3x30	4x57	5ht1_off	18.267	6.07395	No	No	No	No	7	7
32	3x34	4x57	5ht1_off	20.5881	3.08657	No	No	No	No	6	7
33	3x34	4x53	5ht1_off	29.7719	3.08657	No	No	No	No	6	8
34	3x40	5x47	5ht1_off	11.5855	0	Yes	No	Yes	Yes	8	8
35	3x44	5x54	5ht1_off	27.476	0	No	No	No	No	7	8
36	4x63	E2	5ht1_off	14.8784	0	No	No	Yes	Yes	6	4
37	4x63	5x36	5ht1_off	11.4697	3.59042	No	No	No	Yes	6	6
38	5x54	6x41	5ht1_off	25.9957	0	No	No	Yes	No	8	8
39	5x58	6x41	5ht1_off	19.9486	7.45457	Yes	Yes	Yes	No	9	8
40	5x58	5x62	5ht1_off	13.9973	0	Yes	Yes	Yes	Yes	9	6
41	3x43	6x40	5ht1_off	14.2591	0	No	Yes	No	No	8	8
42	6x51	Lig	5ht1_off	17.7383	4.47512	Yes	Yes	Yes	Yes	8	0
43	6x54	7x34	5ht1_off	15.1302	1.26954	No	No	No	No	4	4
44	6x51	7x34	5ht1_off	29.8525	0	Yes	Yes	No	No	8	4
45	6x58	7x34	5ht1_off	13.1313	0	Yes	No	No	No	4	4
46	6x40	7x52	5ht1_off	10.6238	0	No	No	Yes	Yes	8	8
47	2x60	7x42	5ht1_off	23.3271	1.20606	No	No	Yes	Yes	6	7
48	1x32	2x65	Shared	20.8096	10.8347	No	No	No	No	3	6
49	2x37	2x40	Shared	37.1029	42.6049	No	No	No	No	8	9
50	3x52	I2x53	Shared	63.1892	61.5369	Yes	No	Yes	Yes	5	8
51	3x51	5x57	Shared	79.7946	18.0473	Yes	Yes	No	No	8	6
52	5x53	5x57	Shared	81.9244	75.7002	No	No	No	No	7	6
53	3x44	5x53	Shared	82.9414	76.462	No	No	No	No	7	7
54	3x41	3x44	Shared	100	77.2157	Yes	Yes	No	No	6	7
55	3x41	5x50	Shared	88.7518	53.3405	Yes	Yes	No	No	6	9
56	3x40	5x50	Shared	90.1969	55.7328	Yes	No	No	No	8	9
57	7x42	Lig	Shared	64.6795	42.4026	Yes	Yes	Yes	Yes	7	0
58	7x39	7x42	Shared	36.8461	14.8853	Yes	Yes	Yes	Yes	6	7
59	2x38	I2x57	Shared	14.2742	51.5473	No	No	No	Yes	6	7
60	I2x53	I2x57	Shared	14.1836	53.7689	Yes	Yes	No	Yes	8	7
61	3x37	Lig	Shared	29.5403	11.656	No	No	Yes	Yes	7	0
62	3x42	4x49	Shared	22.4812	28.7908	Yes	Yes	No	No	7	7
63	3x41	4x49	Shared	25.759	29.3144	Yes	Yes	No	No	6	7
64	3x43	6x44	Shared	21.5901	66.1192	No	Yes	Yes	Yes	8	9
65	7x45	7x49	Shared	10.5131	13.4492	Yes	No	No	Yes	9	9
66	2x56	7x42	Shared	25.8849	14.7544	Yes	No	Yes	Yes	7	7
67	3x28	E1x50	Shared	54.8109	27.5609	Yes	Yes	Yes	Yes	6	8
68	2x56	3x28	Shared	42.9988	23.7761	Yes	No	Yes	Yes	7	6
69	2x56	3x32	Shared	19.43	11.1164	Yes	No	Yes	No	7	8
70	3x32	Lig	Shared	19.9839	11.9257	Yes	No	Yes	Yes	8	0
71	2x54	2x57	5ht1_on	0	15.4685	No	No	Yes	Yes	7	7
72	1x46	2x54	5ht1_on	6.85766	12.4375	No	No	No	No	7	7
73	1x46	7x47	5ht1_on	6.80731	10.9101	No	No	No	No	7	6
74	6x48	Lig	5ht1_on	3.1368	100	Yes	Yes	Yes	Yes	7	0
75	6x48	7x45	5ht1_on	9.18886	13.83	Yes	Yes	Yes	No	7	9
76	3x40	6x48	5ht1_on	0	47.2705	Yes	No	Yes	Yes	8	7
77	3x48	5x57	5ht1_on	0	63.3222	No	No	No	No	6	6
78	3x48	3x52	5ht1_on	1.64644	62.4335	No	No	Yes	No	6	5
79	2x37	2x38	5ht1_on	0	43.6602	No	No	No	No	8	6
80	2x40	8x50	5ht1_on	0	31.8813	No	No	Yes	Yes	9	8
81	8x50	8x54	5ht1_on	0	10.2039	Yes	Yes	No	Yes	8	7
82	6x44	6x48	5ht1_on	0	54.0506	Yes	Yes	Yes	Yes	9	7
83	2x46	3x42	5ht1_on	0	36.4001	No	Yes	Yes	Yes	9	7
84	2x46	3x46	5ht1_on	0	24.9226	No	Yes	No	No	9	9
85	3x43	7x53	5ht1_on	0	63.9451	No	Yes	No	Yes	8	9
86	5x43	Lig	5ht1_on	1.51553	41.6528	No	No	Yes	Yes	7	0
87	5x39	5x43	5ht1_on	0	40.4467	No	Yes	No	No	8	7
88	5x36	5x39	5ht1_on	0	35.8605	No	Yes	No	Yes	6	8
89	5x36	E2	5ht1_on	0	30.6594	No	Yes	Yes	Yes	6	4
90	E1x49	E2	5ht1_on	0	19.0074	No	No	Yes	Yes	3	4
91	3x28	3x29	5ht1_on	7.15976	10.4539	Yes	Yes	No	No	6	6
92	E2x52	Lig	5ht1_on	1.31917	12.1082	No	No	Yes	Yes	6	0
93	3x29	E2x52	5ht1_on	0	11.16	No	No	No	No	6	6
94	3x33	Lig	5ht1_on	1.51553	11.4139	No	No	Yes	Yes	6	0
95	3x33	4x57	5ht1_on	0	10.3467	No	No	No	No	6	7
96	3x50	7x53	5ht1_on	0	27.2316	No	No	No	Yes	9	9
97	3x50	5x58	5ht1_on	0	46.4255	No	No	Yes	Yes	9	9
98	6x40	7x53	5ht1_on	0	28.6519	No	No	No	Yes	8	9
99	5x58	6x40	5ht1_on	0	27.0412	Yes	Yes	No	No	9	8
100	5x47	5x48	5ht1_on	3.95247	12.6795	Yes	Yes	Yes	Yes	8	6
101	5x45	5x48	5ht1_on	7.60787	10.6998	No	No	Yes	Yes	3	6
102	5x58	6x37	5ht1_on	0	63.0524	Yes	Yes	No	No	9	8
103	5x62	6x37	5ht1_on	0	59.8151	Yes	Yes	No	No	6	8
104	5x62	5x66	5ht1_on	4.61205	16.1985	Yes	Yes	No	Yes	6	6
105	5x66	5x70	5ht1_on	0	11.045	No	Yes	No	No	6	0
106	5x62	6x30	5ht1_on	0	37.4593	Yes	Yes	No	Yes	6	8
107	5x70	6x30	5ht1_on	0	10.9577	No	No	No	Yes	0	8
108	6x51	6x54	5ht1_on	0	14.2863	Yes	Yes	No	No	8	4
109	6x54	7x37	5ht1_on	6.81235	11.4616	No	No	Yes	Yes	4	6
110	7x52	7x53	5ht1_on	0	15.1115	Yes	Yes	No	Yes	8	9
111	8x47	8x50	5ht1_on	8.12144	11.648	No	No	Yes	Yes	9	8
112	8x47	8x48	5ht1_on	0	10.5887	No	No	No	No	9	6
113	5x69	6x30	5ht1_on	0	25.8034	No	Yes	No	Yes	5	8
114	5x67	5x70	5ht1_on	0	18.7693	No	No	No	No	5	0
115	5x67	5x68	5ht1_on	0	12.3066	No	No	No	No	5	7
116	5x69	6x29	5ht1_on	0	19.4041	No	Yes	No	No	5	7
117	6x25	6x29	5ht1_on	0	17.6149	No	No	No	No	0	7
118	2x66	E1x49	5ht1_on	0	16.4286	No	No	No	No	5	3
119	2x65	2x66	5ht1_on	0	13.4849	No	No	No	No	6	5
120	6x22	6x25	5ht1_on	0	16.1469	No	No	No	No	0	0
121	6x18	6x22	5ht1_on	0	14.679	No	No	No	No	0	0
122	6x15	6x18	5ht1_on	0	13.2111	No	No	No	No	0	0
123	6x15	6x16	5ht1_on	0	10.2753	No	No	No	No	0	0
124	2x57	7x42	5ht1_on	0	18.9915	Yes	Yes	Yes	Yes	7	7
125	3x46	3x50	5ht1_on	0	20.0111	No	No	No	No	9	9
126	5x47	6x44	5ht1_on	0	10.0095	Yes	Yes	Yes	Yes	8	9
127	6x48	6x51	5ht1_on	8.32788	10.2714	Yes	Yes	Yes	Yes	7	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	3x32	Shared	13.15	7.74	1	1	2	1
2x56	7x42	Shared	5.05	4.354	1	1	2	1
2x57	7x39	Shared	5.82	4.711	0	1	2	2
2x60	7x39	Shared	8.65	5.4495	1	1	2	2
2x60	7x42	Shared	6.36	4.8035	1	1	2	1
3x32	3x36	5ht1_off	4.67	0	1	1	1	1
3x32	7x42	Shared	11.49	10.114	1	1	1	1
3x32	Lig	Shared	11.78	11.725	1	1	1	0
3x33	Lig	Shared	4.77	9.5835	0	0	1	0
3x36	6x48	Shared	3.92	5.288	1	1	1	1
3x36	Lig	Shared	5.3	9.455	1	1	1	0
3x37	4x53	Shared	6.4	5.117	0	0	1	2
3x37	5x461	5ht1_off	5.03	0	0	0	1	1
3x37	Lig	Shared	4.92	3.5485	0	0	1	0
3x40	5x47	5ht1_off	3.77	0	0	1	1	2
3x40	5x50	Shared	5.08	3.305	0	1	1	2
3x40	6x44	Shared	11.3	4.27	0	1	1	2
3x40	Lig	5ht1_off	4.77	0	0	1	1	0
E2x52	Lig	Shared	3.98	5.3235	0	0	1	0
5x44	5x48	Shared	6.24	3.9965	0	1	1	2
5x44	Lig	5ht1_off	3.94	0	0	1	1	0
5x47	5x48	Shared	11.35	5.879	1	1	2	2
5x47	6x52	Shared	33.22	21.111	1	1	2	1
5x48	6x52	5ht1_off	6.19	0	1	1	2	1
5x48	6x56	Shared	4.69	5.0995	1	1	2	2
6x44	7x45	5ht1_off	8.46	0	0	1	2	2
6x48	6x51	Shared	9.02	4.409	1	1	1	1
6x48	6x52	Shared	6.01	8.067	1	1	1	1
6x48	7x41	Shared	12.67	7.8775	1	1	1	2
6x48	7x42	5ht1_off	3.86	0	1	1	1	1
6x48	7x45	Shared	3.39	10.17	1	1	1	2
6x48	Lig	Shared	17.49	4.132	1	1	1	0
6x51	6x52	Shared	10.72	3.3785	1	1	1	1
6x51	7x34	5ht1_off	3.22	0	1	1	1	2
6x51	7x38	Shared	7.78	4.53	1	1	1	2
6x51	Lig	Shared	15.45	12.7125	1	1	1	0
6x52	Lig	Shared	13.83	9.5175	1	1	1	0
6x54	7x34	Shared	5.02	2.948	0	0	2	2
7x38	7x42	Shared	6.24	3.7115	0	0	2	1
7x39	7x42	Shared	6.75	6.7035	1	1	2	1
7x42	Lig	Shared	4.7	5.911	1	1	1	0
5x43	Lig	Shared	3.01	5.153	0	0	1	0
6x55	6x56	5ht1_off	3	0	0	0	1	2
5x40	Lig	5ht1_off	0.98	0	0	0	1	0
2x57	7x42	5ht1_on	0	5.004	0	1	2	1
3x29	E2x52	5ht1_on	0	3.621	0	0	2	1
3x33	4x57	5ht1_on	0	5.829	0	0	1	2
3x37	4x56	5ht1_on	0	4.94	0	0	1	2
3x40	6x48	5ht1_on	0	6.9875	0	1	1	1
5x39	5x43	5ht1_on	0	3.688	0	2	2	1
5x44	6x52	5ht1_on	0	3.2445	0	1	1	1
5x44	6x56	5ht1_on	0	5.159	0	1	1	2
5x461	Lig	5ht1_on	0	3.259	0	0	1	0
5x47	6x44	5ht1_on	0	7.074	1	1	2	2
5x47	6x48	5ht1_on	0	3.258	1	1	2	1
6x44	6x48	5ht1_on	0	5.664	0	1	2	1
6x55	Lig	5ht1_on	0	7.5395	0	0	1	0
6x51	6x54	5ht1_on	0	2.978	1	1	1	2
5x40	6x59	5ht1_on	0	2.972	0	0	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	5ht1_off	5ht1b_off
	5ht1_on	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on

Network Difference
Value	5ht1_off	5ht1_on
I_min	3.17	3.1685
Number of Linked Nodes	241	278
Number of Specific Nodes	1 (0.41%)	38 (13.67%)
Number of Shared Nodes	240 (99.59%)	240 (86.33%)
Number of Links	282	320
Number of Specific Links	120 (42.55%)	158 (49.38%)
Number of Shared Links	162 (57.45%)	162 (50.63%)
Number of Hubs	38	40
Number of Specific Hubs	15 (39.47%)	17 (42.50%)
Number of Shared Hubs	23 (60.53%)	23 (57.50%)
Average % Shared Neighbours (Jaccard)	36.72
Average % Shared Neighbours (Otsuka)	45.46
Average % Shared Neighbours (Overlap Coefficient)	53.88
Average % Shared Cliques (k3-6)	82.74
Graphlets Similarity	0.660714

Paths Difference
Value	5ht1_off	5ht1_on
Number Of Nodes in MetaPath	69	76
Specific Nodes in MetaPath	23 (33.33%)	30 (39.47%)
Shared Nodes in MetaPath	240 (99.59%)	240 (99.59%)
Number Of Links MetaPath	70	80
Specific Links in MetaPath	47 (67.14%)	57 (71.25%)
Shared Links in MetaPath	162 (57.45%)	162 (57.45%)
Number of Shortest Paths	46796	58164
Length Of Smallest Path	3	3
Average Path Length	13.3492	14.3669
Length of Longest Path	37	38
Minimum Path Strength	1.435	0.60485
Average Path Strength	6.43206	5.23811
Maximum Path Strength	23.525	15.3142
Minimum Path Correlation	0.7	0.7015
Average Path Correlation	0.927279	0.909264
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.44828	2.85714
Average % Of Corr. Nodes	50.0727	38.7386
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	44.7763	45.4242
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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