Orange: nodes, hubs and links specific of 5ht2b_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht2b_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner 5ht2b_on_gp Avg Int. Strength 5ht2b_off Avg Int. Strength 5ht2b_on_gp Num Of Links 5ht2b_off Num Of Links ConSurf
1G.HN.43 5ht2b_on_gp2.8350409
2G.H1.01 5ht2b_on_gp4.9760509
3G.S2.01 5ht2b_on_gp3.730409
4G.S2.06 5ht2b_on_gp5.4650609
5G.S2.08 5ht2b_on_gp4.73250406
6G.S3.03 5ht2b_on_gp6.170708
7G.S3.06 5ht2b_on_gp8.8850407
8G.H2.06 5ht2b_on_gp4.610609
9G.h2s4.01 5ht2b_on_gp6.783330609
10G.S4.03 5ht2b_on_gp3.1450407
11G.S4.04 5ht2b_on_gp3.94750409
12G.S4.05 5ht2b_on_gp5.220407
13G.S4.07 5ht2b_on_gp6.82750408
14G.s4h3.02 5ht2b_on_gp4.4950409
15G.s4h3.04 5ht2b_on_gp7.73250408
16G.H3.08 5ht2b_on_gp5.3540508
17G.H3.09 5ht2b_on_gp4.2440509
18G.H3.12 5ht2b_on_gp3.74250408
19G.H3.13 5ht2b_on_gp7.438570706
20G.H3.17 5ht2b_on_gp5.411670605
21G.S5.04 5ht2b_on_gp4.3880509
22G.S5.05 5ht2b_on_gp3.5850809
23G.HG.03 5ht2b_on_gp5.9350406
24G.HG.15 5ht2b_on_gp7.45250407
25G.hgh4.02 5ht2b_on_gp2.8960508
26G.hgh4.05 5ht2b_on_gp13.4450406
27G.hgh4.17 5ht2b_on_gp8.5850404
28G.hgh4.20 5ht2b_on_gp11.0940503
29G.H4.03 5ht2b_on_gp5.9450404
30G.H4.04 5ht2b_on_gp5.7350404
31G.H4.07 5ht2b_on_gp6.450505
32G.H4.08 5ht2b_on_gp5.5180503
33G.H4.10 5ht2b_on_gp5.4340507
34G.H4.15 5ht2b_on_gp4.8350608
35G.S6.02 5ht2b_on_gp8.79750408
36G.S6.05 5ht2b_on_gp8.970405
37G.s6h5.01 5ht2b_on_gp4.1820509
38G.H5.03 5ht2b_on_gp3.91750409
39G.H5.06 5ht2b_on_gp90404
40G.H5.08 5ht2b_on_gp6.080608
41G.H5.15 5ht2b_on_gp3.57250408
42G.H5.16 5ht2b_on_gp3.3940506
43G.H5.17 5ht2b_on_gp3.260405
44G.H5.19 5ht2b_on_gp4.5780508
45G.H5.22 5ht2b_on_gp3.9850404
46G.H5.23 5ht2b_on_gp5.2550404
47G.H5.25 5ht2b_on_gp4.04750408
48b.1x11 5ht2b_on_gp2.510408
49b.lhb1x6 5ht2b_on_gp5.32250403
50b.l1x3 5ht2b_on_gp8.3320509
51b.b2x3 5ht2b_on_gp3.890406
52b.b2x5 5ht2b_on_gp5.460607
53b.b3x2 5ht2b_on_gp5.15750405
54b.l3x2 5ht2b_on_gp70409
55b.b4x2 5ht2b_on_gp6.0450408
56b.b4x5 5ht2b_on_gp3.930407
57b.b4x6 5ht2b_on_gp8.906670609
58b.l4x1 5ht2b_on_gp3.420405
59b.b5x3 5ht2b_on_gp5.335710709
60b.b5x7 5ht2b_on_gp4.44250407
61b.l5x5 5ht2b_on_gp7.062860709
62b.l6x5 5ht2b_on_gp7.64250404
63b.b7x1 5ht2b_on_gp6.890404
64b.l7x2 5ht2b_on_gp4.080409
65b.b8x3 5ht2b_on_gp3.20406
66b.b8x4 5ht2b_on_gp6.0040506
67b.b9x4 5ht2b_on_gp6.40409
68b.l9x3 5ht2b_on_gp5.533330609
69b.l9x6 5ht2b_on_gp3.5050608
70b.b10x5 5ht2b_on_gp4.471430709
71b.l11x2 5ht2b_on_gp6.870509
72b.b12x6 5ht2b_on_gp8.626670608
73b.b13x7 5ht2b_on_gp7.480507
74b.l13x3 5ht2b_on_gp8.708330609
75b.b14x3 5ht2b_on_gp4.46250405
76b.b15x1 5ht2b_on_gp5.6560509
77b.b15x2 5ht2b_on_gp3.5350406
78b.l15x1 5ht2b_on_gp3.2420507
79b.l15x2 5ht2b_on_gp7.040509
80b.b16x2 5ht2b_on_gp4.1050405
81b.b16x4 5ht2b_on_gp8.6940506
82b.b16x5 5ht2b_on_gp4.1650405
83b.b16x6 5ht2b_on_gp9.5340508
84b.l16x3 5ht2b_on_gp8.90250403
85b.b17x5 5ht2b_on_gp6.68750407
86b.b17x7 5ht2b_on_gp6.73250408
87b.l17x3 5ht2b_on_gp7.3160509
88b.l17x6 5ht2b_on_gp6.6850409
89b.l17x7 5ht2b_on_gp5.5450407
90b.b18x3 5ht2b_on_gp4.7150408
91b.b18x5 5ht2b_on_gp4.1720505
92b.l18x1 5ht2b_on_gp6.7650606
93b.b19x2 5ht2b_on_gp5.040606
94b.b19x4 5ht2b_on_gp3.99250408
95b.l19x2 5ht2b_on_gp3.89250409
96b.b20x3 5ht2b_on_gp3.23250408
97b.b20x4 5ht2b_on_gp9.8460508
98b.b20x6 5ht2b_on_gp5.598330606
99b.b21x1 5ht2b_on_gp8.360407
100b.b21x5 5ht2b_on_gp5.2950404
101b.b21x7 5ht2b_on_gp5.923330605
102b.l21x2 5ht2b_on_gp4.3150404
103b.l21x7 5ht2b_on_gp3.10750405
104b.b22x5 5ht2b_on_gp5.5860507
105b.l22x5 5ht2b_on_gp6.028570709
106b.b23x6 5ht2b_on_gp5.542860707
107b.l23x1 5ht2b_on_gp5.01750406
108b.b24x5 5ht2b_on_gp3.4750405
109b.b24x7 5ht2b_on_gp9.810409
110b.l25x3 5ht2b_on_gp9.71250409
111b.l25x6 5ht2b_on_gp8.5940508
112b.b26x3 5ht2b_on_gp2.93750406
113b.b27x1 5ht2b_on_gp3.410406
114b.l27x1 5ht2b_on_gp11.02830609
115b.l27x2 5ht2b_on_gp7.88250409
116b.b28x4 5ht2b_on_gp5.04750406
117b.b28x6 5ht2b_on_gp7.10409
118g.h1x11 5ht2b_on_gp3.18250409
119g.ctx3 5ht2b_on_gp5.7940509
120g.ctx4 5ht2b_on_gp3.87250407
121g.ctx15 5ht2b_on_gp5.99750409
122g.ctx16 5ht2b_on_gp4.293330608
1233x37 5ht2b_on_gp3.80753.98437
1243x41 5ht2b_on_gp5.8910.015426
1253x50 5ht2b_on_gp6.1452.55333439
126I2x51 5ht2b_on_gp4.1520507
127E2.R213 5ht2b_on_gp5.2027.14667533
1285x48 5ht2b_on_gp4.61255.97426
1295x58 5ht2b_on_gp7.46258.87429
1306x30 5ht2b_on_gp5.0547.28333538
1317x52 5ht2b_on_gp2.60751.6428
1327x53 5ht2b_on_gp5.1165.06529
1337x55 5ht2b_on_gp2.64753.375426
1348x58 5ht2b_on_gp4.252.63333436
1351x50 Shared5.94.6725449
1362x40 Shared6.4225.98559
1372x42 Shared3.4344.31333568
1382x50 Shared6.1825.8225549
1392x57 Shared4.1283.85571578
140E1x50 Shared5.458337.35286677
141E1x52 Shared3.3846.31546
1423x28 Shared5.1357.7625446
1433x32 Shared8.938.1275448
1443x35 Shared5.24256.704456
1453x42 Shared5.9557.712658
1464x50 Shared4.0824.66857579
147E2.N201 Shared4.522.77442
148E2.K211 Shared3.10255.4825445
1495x47 Shared6.9910.5425648
1506x44 Shared4.1166.75667569
1516x48 Shared5.4857.13478
1526x51 Shared7.34757.84467
1536x52 Shared7.61411.908557
1547x39 Shared4.5967.42714577
1557x42 Shared5.8184.914558
1567x54 Shared4.8456.1425447
1578x50 Shared6.868.288659
1588x54 Shared3.3024.92557
159Lig Shared7.675568.244559110
1601x60 5ht2b_off3.803337.9775347
161I1x48 5ht2b_off6.1855.205247
162I1x50 5ht2b_off7.753337.5125348
1632x41 5ht2b_off5.653335.556355
1642x51 5ht2b_off4.223334.91347
1653x25 5ht2b_off5.423335.152359
1663x34 5ht2b_off3.166674.002356
1673x51 5ht2b_off4.866.345348
1684x59 5ht2b_off3.2754.5325244
169E2.N204 5ht2b_off7.062.81343
1705x36 5ht2b_off6.313337.7075345
1715x39 5ht2b_off3.266674.93357
1725x50 5ht2b_off5.583335.4675349
1735x54 5ht2b_off5.766675.4475348
1746x37 5ht2b_off3.8155.9575248
1756x41 5ht2b_off4.4456.33278
1767x37 5ht2b_off4.9055.67245
1777x50 5ht2b_off6.5255.685249
1788x57 5ht2b_off1.034.21155
   
Orange: nodes, hubs and links specific of 5ht2b_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of 5ht2b_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner 5ht2b_on_gp Recurrence 5ht2b_off Recurrence 5ht2b_on_gp Hub1? 5ht2b_off Hub1? 5ht2b_on_gp Hub2? 5ht2b_off Hub2? ConSurf1 ConSurf2
1G.HN.47 b.b4x2 5ht2b_on_gp17.04350NoNoYesNo58
2b.b4x2 b.b5x8 5ht2b_on_gp18.06810YesNoNoNo85
3b.b5x7 b.b5x8 5ht2b_on_gp18.14330YesNoNoNo75
4b.b5x7 b.b8x4 5ht2b_on_gp18.56850YesNoYesNo76
5b.b8x4 b.l8x10 5ht2b_on_gp19.62820YesNoNoNo64
6b.b9x3 b.l8x10 5ht2b_on_gp19.70220NoNoNoNo64
7b.b9x3 b.l7x5 5ht2b_on_gp19.850NoNoNoNo66
8b.l7x3 b.l7x5 5ht2b_on_gp20.07130NoNoNoNo96
9b.l5x3 b.l7x3 5ht2b_on_gp20.1450NoNoNoNo89
10b.l5x3 b.l5x5 5ht2b_on_gp20.21860NoNoYesNo89
11G.S3.06 b.l5x5 5ht2b_on_gp50.79450YesNoYesNo79
12G.S3.04 G.S3.06 5ht2b_on_gp99.93010NoNoYesNo77
13G.S2.03 G.S3.04 5ht2b_on_gp99.95360NoNoNoNo97
14G.S2.02 G.S2.03 5ht2b_on_gp99.96530NoNoNoNo59
15G.S2.02 G.S3.07 5ht2b_on_gp99.98850NoNoNoNo59
16G.H1.01 G.S3.07 5ht2b_on_gp1000YesNoNoNo99
17G.H1.01 G.S1.06 5ht2b_on_gp95.23640YesNoNoNo98
18G.S1.06 G.S3.05 5ht2b_on_gp47.67010NoNoNoNo88
19G.S2.06 G.S3.05 5ht2b_on_gp47.64980YesNoNoNo98
20G.S2.06 G.S3.03 5ht2b_on_gp47.57390YesNoYesNo98
21G.S1.06 G.S4.03 5ht2b_on_gp47.57890NoNoYesNo87
22G.S1.04 G.S4.03 5ht2b_on_gp49.14370NoNoYesNo77
23G.S1.04 G.S3.03 5ht2b_on_gp49.11790NoNoYesNo78
24G.S1.02 G.S3.03 5ht2b_on_gp93.26260NoNoYesNo68
25G.H5.15 G.S1.02 5ht2b_on_gp93.15050YesNoNoNo86
26G.S1.05 G.h2s4.01 5ht2b_on_gp10.1250NoNoYesNo99
27G.S1.07 G.S4.04 5ht2b_on_gp10.20320NoNoYesNo89
28b.l5x5 b.l7x2 5ht2b_on_gp43.89550YesNoYesNo99
29b.l13x6 b.l9x6 5ht2b_on_gp17.09940NoNoYesNo98
30b.l7x2 b.l9x6 5ht2b_on_gp79.61080YesNoYesNo98
31G.H2.06 b.l9x6 5ht2b_on_gp56.99860YesNoYesNo98
32G.H2.06 b.l15x1 5ht2b_on_gp16.720YesNoYesNo97
33b.l13x6 b.l15x1 5ht2b_on_gp16.74540NoNoYesNo97
34G.H2.06 b.l17x6 5ht2b_on_gp39.80370YesNoYesNo99
35G.S4.04 G.S5.04 5ht2b_on_gp10.15170YesNoYesNo99
36G.H5.15 G.H5.19 5ht2b_on_gp47.52050YesNoYesNo88
37G.H5.15 I2x54 5ht2b_on_gp46.7540YesNoNoNo86
38G.H5.19 G.H5.22 5ht2b_on_gp46.70950YesNoYesNo84
39G.H5.22 I2x54 5ht2b_on_gp46.67120YesNoNoNo46
402x37 2x40 5ht2b_on_gp93.1762.46461NoNoYesYes79
412x37 G.H5.22 5ht2b_on_gp93.25310NoNoYesNo74
423x43 7x49 5ht2b_on_gp53.94444.26905NoNoNoNo99
432x50 7x49 5ht2b_on_gp54.69040YesYesNoNo99
447x50 7x51 5ht2b_on_gp86.80740NoYesNoNo96
457x51 7x55 5ht2b_on_gp86.98859.79242NoNoYesNo66
467x54 7x55 5ht2b_on_gp87.41160YesYesYesNo76
477x54 8x50 5ht2b_on_gp89.30049.19093YesYesYesYes79
48b.l17x5 b.l17x6 5ht2b_on_gp20.37780NoNoYesNo69
49b.l17x5 b.l19x2 5ht2b_on_gp20.24870NoNoYesNo69
50b.b19x6 b.l19x2 5ht2b_on_gp39.97240NoNoYesNo99
51b.b19x6 b.l17x3 5ht2b_on_gp25.31830NoNoYesNo99
52b.b19x4 b.l17x3 5ht2b_on_gp13.86150YesNoYesNo89
53b.b19x4 b.b20x6 5ht2b_on_gp19.1940YesNoYesNo86
54b.b17x7 b.b20x6 5ht2b_on_gp24.7980YesNoYesNo86
55b.b17x7 b.b21x1 5ht2b_on_gp22.40820YesNoYesNo87
56b.1x19 b.b21x1 5ht2b_on_gp18.41550NoNoYesNo67
57b.1x15 b.1x19 5ht2b_on_gp15.21470NoNoNoNo76
58b.1x15 g.h1x15 5ht2b_on_gp14.41440NoNoNoNo78
59b.1x11 g.h1x15 5ht2b_on_gp13.61570YesNoNoNo88
60b.l17x6 b.l19x1 5ht2b_on_gp20.37780YesNoNoNo99
61b.l19x1 b.l19x2 5ht2b_on_gp20.24870NoNoYesNo99
62b.b19x6 b.l17x7 5ht2b_on_gp14.39150NoNoYesNo97
63b.b19x4 b.l17x7 5ht2b_on_gp13.86120YesNoYesNo87
64b.b20x4 b.l17x3 5ht2b_on_gp10.92960YesNoYesNo89
65b.b4x6 b.b5x3 5ht2b_on_gp15.62950YesNoYesNo99
66b.b3x2 b.b4x6 5ht2b_on_gp15.29130YesNoYesNo59
67b.l26x5 g.ctx4 5ht2b_on_gp12.65690NoNoYesNo57
68g.ctx3 g.ctx4 5ht2b_on_gp12.3470YesNoYesNo97
69b.l13x5 b.l15x1 5ht2b_on_gp34.22480NoNoYesNo57
70b.l13x5 b.l15x2 5ht2b_on_gp33.69660NoNoYesNo59
71b.l13x3 b.l15x2 5ht2b_on_gp25.41190YesNoYesNo99
72b.b11x5 b.l13x7 5ht2b_on_gp11.77320NoNoNoNo69
73b.b11x5 b.b14x3 5ht2b_on_gp10.70540NoNoYesNo65
74b.b15x1 b.b16x6 5ht2b_on_gp12.31870YesNoYesNo98
75b.b11x1 b.l10x2 5ht2b_on_gp11.25150NoNoNoNo55
763x28 Lig 5ht2b_on_gp16.5290YesYesYesYes60
773x36 Lig 5ht2b_on_gp10.90563.19812NoNoYesYes70
783x36 6x48 5ht2b_on_gp14.01760NoNoYesYes78
795x47 6x44 5ht2b_on_gp33.00660YesYesYesYes89
806x51 6x52 5ht2b_on_gp29.16876.01482YesYesYesYes77
813x40 6x52 5ht2b_on_gp14.9620NoNoYesYes87
823x40 6x44 5ht2b_on_gp15.54370NoNoYesYes89
835x461 Lig 5ht2b_on_gp21.76080NoNoYesYes70
843x37 5x461 5ht2b_on_gp22.14423.41818YesNoNoNo77
853x37 3x41 5ht2b_on_gp11.64360YesNoYesNo76
863x41 4x49 5ht2b_on_gp12.98220YesNoNoNo67
873x42 4x49 5ht2b_on_gp13.1721.83379YesYesNoNo87
883x37 4x53 5ht2b_on_gp11.68110YesNoNoNo78
893x38 4x53 5ht2b_on_gp11.82670.572141NoNoNoNo88
903x38 3x42 5ht2b_on_gp12.00690NoNoYesYes88
91E2.I205 E2.P202 5ht2b_on_gp11.67590NoNoNoNo23
92E2.I195 E2.I205 5ht2b_on_gp13.62110NoNoNoNo52
933x29 E2.I195 5ht2b_on_gp19.45490NoNoNoNo55
94G.HN.47 b.b5x3 5ht2b_on_gp16.72410NoNoYesNo59
95G.S3.06 G.h2s4.01 5ht2b_on_gp13.07870YesNoYesNo79
96G.S2.01 G.S3.06 5ht2b_on_gp36.05660YesNoYesNo97
97G.S2.01 b.l7x2 5ht2b_on_gp36.08340YesNoYesNo99
982x40 8x50 Shared91.664157.6836YesYesYesYes99
991x50 2x50 Shared84.591816.5994YesYesYesYes99
1001x50 7x50 Shared86.626420.2963YesYesNoYes99
1013x28 E1x50 Shared14.588968.9577YesYesYesYes67
1025x47 6x48 Shared14.40210.8927YesYesYesYes88
1033x43 6x44 Shared51.536160.0822NoNoYesYes99
1046x51 Lig Shared21.790951.9108YesYesYesYes70
1055x47 6x52 Shared14.996914.8463YesYesYesYes87
1062x46 3x42 Shared27.446924.7194NoNoYesYes98
1072x46 2x50 Shared27.635712.015NoNoYesYes99
1083x29 4x61 Shared23.344812.169NoNoNoNo56
1094x61 5x39 Shared27.232718.1398NoNoNoYes67
1105x39 Lig Shared29.176340.3433NoYesYesYes70
1113x33 Lig 5ht2b_off1.9465436.6977NoNoYesYes70
1123x37 Lig 5ht2b_off016.9735YesNoYesYes70
113E2x52 Lig 5ht2b_off013.2766NoNoYesYes50
1146x52 Lig 5ht2b_off045.9987YesYesYesYes70
1152x66 E1x51 5ht2b_off014.9123NoNoNoNo33
116E1x50 E1x51 5ht2b_off0.97270238.6049YesYesNoNo73
1172x60 3x28 5ht2b_off075.7133NoNoYesYes76
1182x60 7x39 5ht2b_off0.58876677.5251NoNoYesYes77
1197x39 7x42 5ht2b_off3.5309910.1225YesYesYesYes78
1201x35 1x38 5ht2b_off010.0051NoNoNoNo45
1211x38 1x411 5ht2b_off013.3133NoNoNoNo54
1221x411 1x42 5ht2b_off019.8856NoNoNoNo47
1231x42 2x57 5ht2b_off1.1775126.3992NoNoYesYes78
1242x57 7x42 5ht2b_off3.5309921.2206YesYesYesYes88
1252x61 7x39 5ht2b_off010.1152NoNoYesYes67
1262x50 3x39 5ht2b_off0.20472513.1446YesYesNoNo99
1273x39 7x46 5ht2b_off014.0248NoNoNoNo99
1286x48 7x46 5ht2b_off014.0101YesYesNoNo89
1296x48 6x51 5ht2b_off087.3762YesYesYesYes87
1307x49 7x50 5ht2b_off018.4699NoNoNoYes99
1316x44 7x49 5ht2b_off015.4918YesYesNoNo99
1326x44 6x48 5ht2b_off0100YesYesYesYes98
1336x48 6x52 5ht2b_off0.0014760730.3088YesYesYesYes87
1341x50 2x51 5ht2b_off1.5972923.1717YesYesNoYes97
1357x51 8x54 5ht2b_off016.8782NoNoYesYes67
1368x50 8x54 5ht2b_off045.874YesYesYesYes97
1371x57 2x40 5ht2b_off081.3467NoNoYesYes89
1381x57 2x44 5ht2b_off0.61446683.2759NoNoNoNo87
1392x41 2x44 5ht2b_off085.1904NoYesNoNo57
1402x41 4x46 5ht2b_off098.1295NoYesNoNo57
1412x45 4x46 5ht2b_off0.19499956.4439NoNoNoNo97
1422x45 4x50 5ht2b_off0.002846748.8521NoNoYesYes99
1433x35 4x50 5ht2b_off039.5291YesYesYesYes69
1442x53 3x35 5ht2b_off1.557249.6002NoNoYesYes76
1452x53 2x56 5ht2b_off010.6286NoNoNoNo77
1461x52 8x54 5ht2b_off2.3821926.2231NoNoYesYes77
1471x52 8x57 5ht2b_off014.5749NoNoNoYes75
1482x48 2x52 5ht2b_off012.1837NoNoNoNo67
1492x52 3x35 5ht2b_off0.20970716.218NoNoYesYes76
1501x60 I1x50 5ht2b_off014.5162NoYesNoYes78
1512x40 I1x50 5ht2b_off0.57653617.7437YesYesNoYes98
1522x42 3x42 5ht2b_off1.2006222.915YesYesYesYes88
1533x42 4x50 5ht2b_off0.58834520.9198YesYesYesYes89
1543x43 6x41 5ht2b_off063.4637NoNoNoYes98
1553x46 6x41 5ht2b_off048.7787NoNoNoYes98
1562x42 3x46 5ht2b_off0.22233348.3459YesYesNoNo89
1572x59 3x28 5ht2b_off0.97293913.8121NoNoYesYes56
1582x59 E1x52 5ht2b_off011.5455NoNoYesYes56
159E1x50 E1x52 5ht2b_off8.7545312.4257YesYesYesYes76
160E1x49 E1x51 5ht2b_off022.1741NoNoNoNo33
1613x25 E1x50 5ht2b_off1.945814.8683NoYesYesYes97
1623x24 E1x52 5ht2b_off1.945814.4282NoNoYesYes56
1634x60 5x39 5ht2b_off010.3939NoNoNoYes87
1643x33 4x57 5ht2b_off0.97328234.6512NoNoNoNo78
1653x34 4x57 5ht2b_off033.7417NoYesNoNo68
1663x37 4x56 5ht2b_off0.79256910.2252YesNoNoNo76
1676x44 6x45 5ht2b_off032.7808YesYesNoNo95
1685x54 6x45 5ht2b_off026.4138NoYesNoNo85
1693x44 5x54 5ht2b_off1.009521.9761NoNoNoYes78
1703x44 5x50 5ht2b_off017.1936NoNoNoYes79
1713x47 5x57 5ht2b_off0.20198411.6335NoNoNoNo96
1726x37 6x41 5ht2b_off044.6123NoYesNoYes88
1733x50 6x37 5ht2b_off0.2017240.2626YesNoNoYes98
1743x50 3x54 5ht2b_off035.8615YesNoNoNo99
1753x54 5x65 5ht2b_off0.66570626.6192NoNoNoNo98
1765x61 5x65 5ht2b_off021.9101NoNoNoNo98
1773x51 5x61 5ht2b_off0.30894619.5335NoYesNoNo89
1785x36 E2x52 5ht2b_off1.9455910.2839NoYesNoNo55
1795x36 5x39 5ht2b_off011.5015NoYesNoYes57
1805x36 E2.R213 5ht2b_off0.00057988410.4819NoYesYesNo53
181E1x49 E2.N204 5ht2b_off2.9196619.7682NoNoNoYes33
182E2.N201 E2.N204 5ht2b_off012.4257YesYesNoYes23
1836x51 6x55 5ht2b_off028.475YesYesNoNo76
1845x40 6x55 5ht2b_off4.8659924.4187NoNoNoNo66
1855x40 E2.K211 5ht2b_off013.9294NoNoYesYes65
1865x44 6x52 5ht2b_off0.4017814.6776NoNoYesYes77
1875x44 6x56 5ht2b_off0.0033738712.3744NoNoNoNo76
1885x47 5x48 5ht2b_off0.79172610.9YesYesYesNo86
1895x51 6x45 5ht2b_off0.19990215.3525NoNoNoNo65
1905x51 5x55 5ht2b_off012.8292NoNoNoNo65
1915x55 5x59 5ht2b_off0.20198410.2912NoNoNoNo53
1926x51 7x34 5ht2b_off1.5700946.006YesYesNoNo75
1936x54 7x34 5ht2b_off1.1776427.5728NoNoNoNo55
1946x54 7x37 5ht2b_off0.78513611.2008NoNoNoYes55
1956x54 7x30 5ht2b_off013.9661NoNoNoNo54
1967x31 7x34 5ht2b_off016.7168NoNoNoNo25
1977x31 7x35 5ht2b_off013.9661NoNoNoNo25
1987x32 7x35 5ht2b_off011.2008NoNoNoNo25
1995x47 6x49 5ht2b_off2.814211.3695YesYesNoNo86
2006x40 6x41 5ht2b_off010.0565NoNoNoYes88
2013x28 3x29 5ht2b_off010.966YesYesNoNo65
2027x38 7x39 5ht2b_off059.9795NoNoYesYes67
2037x42 Lig 5ht2b_off036.1623YesYesYesYes80
2043x34 4x50 5ht2b_off029.854NoYesYesYes69
2052x53 2x57 5ht2b_off041.0915NoNoYesYes78
2062x46 7x50 5ht2b_off012.9025NoNoNoYes99
2076x51 7x38 5ht2b_off5.445951.3167YesYesNoNo76
2082x57 7x39 5ht2b_off0.00092254237.996YesYesYesYes87
2092x42 4x46 5ht2b_off0.19926944.2823YesYesNoNo87
2105x54 6x41 5ht2b_off1.4129413.46NoYesNoYes88

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
3x32LigShared15.3518.041510
3x33LigShared12.3615.140010
3x36LigShared7.935.871510
3x37Lig5ht2b_off5.5600010
E2x51Lig5ht2b_off3.3700010
E2x52Lig5ht2b_off5.2200010
5x39LigShared5.512.860010
6x51LigShared16.5415.231510
6x52Lig5ht2b_off11.9401510
7x38LigShared3.374.661510
7x42Lig5ht2b_off3.5401510
2x563x32Shared5.842.921521
2x567x42Shared3.793.791521
2x577x39Shared4.653.491522
2x577x42Shared3.594.791521
2x59E1x505ht2b_off3.5203022
2x593x28Shared15.277.053021
3x28E1x50Shared7.54.693012
3x283x295ht2b_off5.6903012
3x294x61Shared2.984.470022
3x323x36Shared4.424.421511
3x327x42Shared6.910.341511
3x334x57Shared3.393.390012
3x374x56Shared4.563.040012
4x605x395ht2b_off7.2200021
4x615x39Shared5.243.930021
5x36E2x52Shared6.0912.1872421
5x365x395ht2b_off4.29072421
5x406x55Shared8.417.010021
5x446x52Shared5.283.960521
5x446x555ht2b_off4.4700521
5x476x48Shared4.013.011522
5x476x52Shared24.6518.221521
6x486x515ht2b_off6.0101521
6x486x52Shared8.028.021521
6x516x52Shared9.655.361511
6x516x555ht2b_off6.0401511
6x517x34Shared4.874.871512
6x517x38Shared3.933.931511
7x387x395ht2b_off3.6801512
7x397x42Shared6.753.861521
2x603x285ht2b_off2.5900021
2x607x39Shared2.593.890022
5x385x395ht2b_off2.3900021
3x375x461Shared1.823.360011
4x565x435ht2b_off1.7600022
2x563x285ht2b_on_gp06.131521
3x28Lig5ht2b_on_gp02.673010
3x29E2x525ht2b_on_gp05.540021
3x366x485ht2b_on_gp02.471512
3x373x415ht2b_on_gp02.430012
3x374x535ht2b_on_gp06.40012
3x406x525ht2b_on_gp02.510021
5x395x435ht2b_on_gp03.010012
5x461Lig5ht2b_on_gp02.460010
7x387x425ht2b_on_gp06.311511
6x55Lig5ht2b_on_gp02.150010
E2.T210E2x515ht2b_on_gp01.590021

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
5ht2b_on_gp 7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5ht2b_off 6DRZ-5-HT2B-Methysergide
Network Difference
Value 5ht2b_on_gp 5ht2b_off
Imin 2.39 2.98
Number of Linked Nodes 845 284
Number of Specific Nodes 599 (70.89%) 38  (13.38%)
Number of Shared Nodes 246 (29.11%) 246  (86.62%)
Number of Links 1031 325
Number of Specific Links 857 (83.12%) 151  (46.46%)
Number of Shared Links 174 (16.88%) 174  (53.54%)
Number of Hubs 159 44
Number of Specific Hubs 134 (84.28%) 19  (43.18%)
Number of Shared Hubs 25 (15.72%) 25  (56.82%)
Average % Shared Neighbours (Jaccard) 13.56
Average % Shared Neighbours (Otsuka) 16.64
Average % Shared Neighbours (Overlap Coefficient) 19.62
Average % Shared Cliques (k3-6) 76.54
Graphlets Similarity 0.633129
Paths Difference
Value 5ht2b_on_gp 5ht2b_off
Number Of Nodes in MetaPath 106 101
Specific Nodes in MetaPath 84 (79.25%) 79  (78.22%)
Shared Nodes in MetaPath 246 (29.11%) 246  (29.11%)
Number Of Links MetaPath 110 113
Specific Links in MetaPath 97 (88.18%) 100  (88.50%)
Shared Links in MetaPath 174 (16.88%) 174  (16.88%)
Number of Shortest Paths 4510269 51510
Length Of Smallest Path 3 3
Average Path Length 41.4212 11.6294
Length of Longest Path 75 27
Minimum Path Strength 1.3 1.22
Average Path Strength 5.76275 5.72805
Maximum Path Strength 21.76 18.295
Minimum Path Correlation 0.7 0.7
Average Path Correlation 0.991983 0.943545
Maximum Path Correlation 1 0.99
Minimum % Of Corr. Nodes 2.32558 5.26316
Average % Of Corr. Nodes 27.7341 62.9928
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 53.1869 47.8568
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 5ht2b_off_on_gp.zip<



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