Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.43 2.835439
2G.H1.01 4.976529
3G.S2.01 3.73419
4G.S2.06 5.465629
5G.S2.08 4.7325426
6G.S3.03 6.17728
7G.S3.06 8.885417
8G.H2.06 4.61619
9G.h2s4.01 6.78333619
10G.S4.03 3.145427
11G.S4.04 3.9475419
12G.S4.05 5.22427
13G.S4.07 6.8275428
14G.s4h3.02 4.495429
15G.s4h3.04 7.73254118
16G.H3.08 5.354518
17G.H3.09 4.244519
18G.H3.12 3.7425418
19G.H3.13 7.43857716
20G.H3.17 5.41167645
21G.S5.04 4.388519
22G.S5.05 3.585829
23G.HG.03 5.935426
24G.HG.15 7.45254117
25G.hgh4.02 2.8965118
26G.hgh4.05 13.4454116
27G.hgh4.17 8.585414
28G.hgh4.20 11.094513
29G.H4.03 5.945414
30G.H4.04 5.735414
31G.H4.07 6.45515
32G.H4.08 5.518503
33G.H4.10 5.4345117
34G.H4.15 4.835618
35G.S6.02 8.7975408
36G.S6.05 8.97415
37G.s6h5.01 4.182529
38G.H5.03 3.9175429
39G.H5.06 9424
40G.H5.08 6.08628
41G.H5.15 3.5725428
42G.H5.16 3.3945156
43G.H5.17 3.264155
44G.H5.19 4.578528
45G.H5.22 3.985424
46G.H5.23 5.255424
47G.H5.25 4.0475478
48b.1x11 2.51408
49b.lhb1x6 5.3225483
50b.l1x3 8.332539
51b.b2x3 3.89436
52b.b2x5 5.46637
53b.b3x2 5.1575435
54b.l3x2 7439
55b.b4x2 6.045408
56b.b4x5 3.934187
57b.b4x6 8.90667639
58b.l4x1 3.42435
59b.b5x3 5.33571739
60b.b5x7 4.4425407
61b.l5x5 7.06286719
62b.l6x5 7.64254124
63b.b7x1 6.894124
64b.l7x2 4.08419
65b.b8x3 3.24126
66b.b8x4 6.004506
67b.b9x4 6.4409
68b.l9x3 5.53333699
69b.l9x6 3.505618
70b.b10x5 4.471437129
71b.l11x2 6.87599
72b.b12x6 8.62667698
73b.b13x7 7.48567
74b.l13x3 8.70833669
75b.b14x3 4.46254175
76b.b15x1 5.656569
77b.b15x2 3.535416
78b.l15x1 3.242517
79b.l15x2 7.04569
80b.b16x2 4.105465
81b.b16x4 8.694566
82b.b16x5 4.165405
83b.b16x6 9.534568
84b.l16x3 8.90254203
85b.b17x5 6.6875417
86b.b17x7 6.7325418
87b.l17x3 7.316519
88b.l17x6 6.685419
89b.l17x7 5.545417
90b.b18x3 4.715418
91b.b18x5 4.172505
92b.l18x1 6.765606
93b.b19x2 5.04616
94b.b19x4 3.9925418
95b.l19x2 3.8925419
96b.b20x3 3.2325448
97b.b20x4 9.846518
98b.b20x6 5.59833616
99b.b21x1 8.36417
100b.b21x5 5.295444
101b.b21x7 5.92333645
102b.l21x2 4.315404
103b.l21x7 3.1075445
104b.b22x5 5.586507
105b.l22x5 6.02857789
106b.b23x6 5.54286747
107b.l23x1 5.0175446
108b.b24x5 3.475405
109b.b24x7 9.81489
110b.l25x3 9.71254229
111b.l25x6 8.594548
112b.b26x3 2.93754216
113b.b27x1 3.414216
114b.l27x1 11.0283649
115b.l27x2 7.88254229
116b.b28x4 5.0475406
117b.b28x6 7.1409
118g.h1x11 3.18254169
119g.ctx3 5.794509
120g.ctx4 3.8725407
121g.ctx15 5.9975439
122g.ctx16 4.29333638
1231x50 5.9409
1242x40 6.4225109
1252x42 3.434508
1262x50 6.182509
1272x57 4.128558
128E1x50 5.458336137
129E1x52 3.3845136
1303x28 5.135406
1313x32 8.93458
1323x35 5.2425406
1333x37 3.8075407
1343x41 5.89406
1353x42 5.9556148
1363x50 6.145479
137I2x51 4.152527
1384x50 4.0825149
139E2.N201 4.52402
140E2.K211 3.1025405
141E2.R213 5.2025243
1425x47 6.99658
1435x48 4.6125456
1445x58 7.4625409
1456x30 5.0545158
1466x44 4.116559
1476x48 5.485458
1486x51 7.3475457
1496x52 7.614557
1507x39 4.596557
1517x42 5.818558
1527x52 2.6075478
1537x53 5.116579
1547x54 4.8454107
1557x55 2.64754106
1568x50 6.866109
1578x54 3.3025107
1588x58 4.254236
159Lig 7.67556950
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1G.HN.47 b.b4x2 17.04354.23NoYes058
2b.b4x2 b.b5x8 18.06813.35YesNo085
3b.b5x7 b.b5x8 18.14333.39YesNo075
4b.b5x7 b.b8x4 18.56852.42YesYes076
5b.b8x4 b.l8x10 19.62827.57YesNo064
6b.b9x3 b.l8x10 19.70222.85NoNo064
7b.b9x3 b.l7x5 19.852.73NoNo066
8b.l7x3 b.l7x5 20.07134.2NoNo096
9b.l5x3 b.l7x3 20.1458.83NoNo089
10b.l5x3 b.l5x5 20.21863.71NoYes089
11G.S3.06 b.l5x5 50.794514.03YesYes179
12G.S3.04 G.S3.06 99.930114.71NoYes077
13G.S2.03 G.S3.04 99.95364.92NoNo097
14G.S2.02 G.S2.03 99.96534.66NoNo059
15G.S2.02 G.S3.07 99.98852.39NoNo059
16G.H1.01 G.S3.07 10011.06YesNo099
17G.H1.01 G.S1.06 95.23644.23YesNo098
18G.S1.06 G.S3.05 47.67017.07NoNo088
19G.S2.06 G.S3.05 47.64983.73YesNo098
20G.S2.06 G.S3.03 47.573913.93YesYes298
21G.S1.06 G.S4.03 47.57894.28NoYes087
22G.S1.04 G.S4.03 49.14372.85NoYes277
23G.S1.04 G.S3.03 49.11794.87NoYes278
24G.S1.02 G.S3.03 93.26267.31NoYes068
25G.H5.15 G.S1.02 93.15052.85YesNo086
26G.S1.05 G.h2s4.01 10.12515.83NoYes199
27G.S1.07 G.S4.04 10.20322.44NoYes189
28b.l5x5 b.l7x2 43.89555.69YesYes199
29b.l13x6 b.l9x6 17.09943.45NoYes098
30b.l7x2 b.l9x6 79.61083.52YesYes198
31G.H2.06 b.l9x6 56.99863.58YesYes198
32G.H2.06 b.l15x1 16.723.23YesYes197
33b.l13x6 b.l15x1 16.74543.11NoYes097
34G.H2.06 b.l17x6 39.80375.53YesYes199
35G.S4.04 G.S5.04 10.15174.87YesYes199
36G.H5.15 G.H5.19 47.52054.25YesYes288
37G.H5.15 I2x54 46.7544.25YesNo286
38G.H5.19 G.H5.22 46.70956.57YesYes284
39G.H5.22 I2x54 46.67122.63YesNo246
402x37 2x40 93.17615.12NoYes079
412x37 G.H5.22 93.25313.37NoYes074
422x40 8x50 91.66416.04YesYes1099
433x43 7x49 53.94444.12NoNo099
442x50 7x49 54.69048.08YesNo099
451x50 2x50 84.59184.04YesYes099
461x50 7x50 86.62649.77YesNo099
477x50 7x51 86.80743.28NoNo096
487x51 7x55 86.98852.77NoYes066
497x54 7x55 87.41162.95YesYes1076
507x54 8x50 89.30049.08YesYes1079
51b.l17x5 b.l17x6 20.37785.89NoYes169
52b.l17x5 b.l19x2 20.24875.89NoYes169
53b.b19x6 b.l19x2 39.97244.42NoYes199
54b.b19x6 b.l17x3 25.31839.76NoYes199
55b.b19x4 b.l17x3 13.86152.74YesYes189
56b.b19x4 b.b20x6 19.1942.59YesYes186
57b.b17x7 b.b20x6 24.7987.5YesYes186
58b.b17x7 b.b21x1 22.40825.97YesYes187
59b.1x19 b.b21x1 18.41555.96NoYes067
60b.1x15 b.1x19 15.21476.26NoNo076
61b.1x15 g.h1x15 14.41443.25NoNo078
62b.1x11 g.h1x15 13.61571.58YesNo088
63b.l17x6 b.l19x1 20.377810.65YesNo199
64b.l19x1 b.l19x2 20.24872.66NoYes199
65b.b19x6 b.l17x7 14.39153.1NoYes197
66b.b19x4 b.l17x7 13.86127.6YesYes187
67b.b20x4 b.l17x3 10.929614.67YesYes189
68b.b4x6 b.b5x3 15.62958.12YesYes399
69b.b3x2 b.b4x6 15.29135.69YesYes359
70b.l26x5 g.ctx4 12.65696.71NoYes057
71g.ctx3 g.ctx4 12.3473.22YesYes097
72b.l13x5 b.l15x1 34.22481.96NoYes057
73b.l13x5 b.l15x2 33.69663.35NoYes059
74b.l13x3 b.l15x2 25.411912.61YesYes699
75b.b11x5 b.l13x7 11.77324.85NoNo069
76b.b11x5 b.b14x3 10.70544.5NoYes065
77b.b15x1 b.b16x6 12.318712.03YesYes698
78b.b11x1 b.l10x2 11.251514.36NoNo055
793x28 E1x50 14.58894.69YesYes067
803x28 Lig 16.5292.67YesYes060
813x36 Lig 10.90565.87NoYes570
823x36 6x48 14.01762.47NoYes578
835x47 6x48 14.4023.01YesYes588
845x47 6x44 33.00663.22YesYes589
853x43 6x44 51.53612.44NoYes099
866x51 Lig 21.790915.23YesYes570
876x51 6x52 29.16875.36YesYes577
885x47 6x52 14.996918.22YesYes587
893x40 6x52 14.9622.51NoYes087
903x40 6x44 15.54373.77NoYes089
915x461 Lig 21.76082.46NoYes070
923x37 5x461 22.14423.36YesNo077
933x37 3x41 11.64362.43YesYes076
943x41 4x49 12.98222.45YesNo067
953x42 4x49 13.1725.54YesNo087
962x46 3x42 27.44699NoYes098
972x46 2x50 27.63574.07NoYes099
983x37 4x53 11.68116.4YesNo078
993x38 4x53 11.82673.42NoNo088
1003x38 3x42 12.00692.93NoYes1488
101E2.I205 E2.P202 11.67591.69NoNo023
102E2.I195 E2.I205 13.62111.47NoNo052
1033x29 E2.I195 19.45492.85NoNo055
1043x29 4x61 23.34484.47NoNo056
1054x61 5x39 27.23273.93NoNo067
1065x39 Lig 29.17632.86NoYes070
107G.HN.47 b.b5x3 16.72412.82NoYes359
108G.S3.06 G.h2s4.01 13.07874.29YesYes179
109G.S2.01 G.S3.06 36.05662.51YesYes197
110G.S2.01 b.l7x2 36.08344.28YesYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x563x286.135NoYes7621
2x563x322.925NoYes7821
2x567x423.795NoYes7822
2x593x287.050NoYes5621
3x28E1x504.690YesYes6712
3x28Lig2.670YesYes6010
3x323x364.425YesNo8711
3x327x4210.345YesYes8812
3x32Lig18.045YesYes8010
3x334x573.390NoNo7812
3x33Lig15.140NoYes7010
3x366x482.475NoYes7812
3x36Lig5.875NoYes7010
3x375x4613.360YesNo7721
4x615x393.930NoNo6721
5x395x433.010NoNo7612
5x39Lig2.860NoYes7010
5x406x557.010NoNo6621
5x461Lig2.460NoYes7010
6x486x528.025YesYes8722
6x516x525.365YesYes7712
6x517x344.875YesNo7512
6x517x383.935YesNo7611
6x51Lig15.235YesYes7010
7x387x426.315NoYes6812
7x38Lig4.665NoYes6010
6x55Lig2.150NoYes6010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
100.00Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
77.78Consensus5ht2_onOrthosteric Ligand5ht2b_on
77.78Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
70.00Single7SRQLSD7SRQ-5-HT2B-LSD
64.29Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
63.64Single6DS0Ly2660976DS0-5-HT2B-Ly266097
63.64Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
61.54Single5TVNLSD5TVN-5-HT2B-LSD
61.54Single6E67BI1671076E67-β2-BI167107-Gs (fused)
61.54Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
61.54Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
61.54Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
61.54Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
61.54Single7WC6LSD7WC6-5-HT2A-LSD
61.54Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
61.54Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
61.54Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
61.54Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
60.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
58.33Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
58.33Single6PS5S-Propranolol6PS5-β2-S-Propranolol
58.33Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
58.33Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
58.33Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
58.33Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
58.33Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
58.33Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
58.33Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
58.33Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
58.33Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
58.33Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
58.33Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
58.33Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
57.14Single3P0GBI1671073P0G-β2-BI167107
57.14Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
57.14Single5D5AS-Carazolol5D5A-β2-S-Carazolol
57.14Single5D5BS-Carazolol5D5B-β2-S-Carazolol
57.14Single6H7JIsoprenaline6H7J-β1-Isoprenaline
57.14Single6WGTLSD6WGT-5-HT2A-LSD
57.14Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
57.14Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
57.14Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
57.14Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
54.55Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
54.55Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
54.55Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
54.55Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
54.55Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
54.55Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
54.55Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
54.55Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
54.55Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
53.85Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
53.85Single2Y02Carmoterol2Y02-β1-Carmoterol
53.85Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
53.85Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
53.85Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
53.85Single4QKX35V4QKX-β2-35V
53.85Single6DRXLisuride6DRX-5-HT2B-Lisuride
53.85Single6H7MSalbutamol6H7M-β1-Salbutamol
53.85Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
53.85Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
53.85Single6PS1Timolol6PS1-β2-Timolol
53.85Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
53.85Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
53.85Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
53.85Single7BU7BI1671077BU7-β1-BI167107
53.85Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
53.85Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
53.85Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
53.85Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
53.85Single7WC7Lisuride7WC7-5-HT2A-Lisuride
53.85Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
53.85Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
53.85Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
53.85Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
53.85Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
53.85Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
53.85Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
53.85Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
53.85Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
53.85Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
53.85Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
53.85Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
53.85Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
53.85Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
53.85Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
53.85Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
53.85Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
53.85Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
53.85Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
53.85Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
53.85Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
53.85Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
53.85Single8JJOAlprenolol8JJO-β2-Alprenolol
53.85Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
53.85Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
53.85Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
53.85Single8X63Mepyramine8X63-H1-Mepyramine
53.85Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
53.85Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
53.85Consensus5ht5_onOrthosteric Ligand5ht5a_on
53.85Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
53.85Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
53.85Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
53.85Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
53.85Consensusalpha2_onOrthosteric Ligandalpha2b_on
53.85Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
53.85Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
53.85Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
53.85Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
53.85Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
53.85Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
53.85Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
53.85Consensushistamine_offOrthosteric Ligandh1_off
53.33Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
53.33Single3D4STimolol3D4S-β2-Timolol
53.33Single4AMIBucindolol4AMI-β1-Bucindolol
53.33Single4LDEBI1671074LDE-β2-BI167107
53.33Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
53.33Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
53.33Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
53.33Single8JJ8Formoterol8JJ8-β2-Formoterol
53.33Consensusalpha1_offOrthosteric Ligandalpha1a_off
53.33Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
53.33Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
53.33Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
52.94Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
50.00Single2RH1S-Carazolol2RH1-β2-S-Carazolol
50.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
50.00Single2YCWS-Carazolol2YCW-β1-S-Carazolol
50.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
50.00Single5D6LS-Carazolol5D6L-β2-S-Carazolol
50.00Single5JQHS-Carazolol5JQH-β2-S-Carazolol
50.00Single6AKXA4R6AKX-CCR5-A4R
50.00Single6H7LDobutamine6H7L-β1-Dobutamine
50.00Single6IBLArformoterol6IBL-β1-Arformoterol
50.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
50.00Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
50.00Single6PS6Timolol6PS6-β2-Timolol
50.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
50.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
50.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
50.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
50.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
50.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
50.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
50.00Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
50.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
50.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
50.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
50.00Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
50.00Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
50.00Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
50.00Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
50.00Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
50.00Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
50.00Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
50.00Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
50.00Single9CHUNoradrenaline9CHU-β2-Noradrenaline
50.00Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
50.00Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
50.00Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
50.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
50.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
50.00Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
50.00Consensusalpha2_offOrthosteric Ligandalpha2c_off
50.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
50.00Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
50.00Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
50.00Consensusamine_offonOrthosteric Ligandamine_off amine_on
50.00Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
50.00Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
50.00Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
50.00Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
50.00Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
50.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
50.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
50.00Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
50.00Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
50.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
50.00Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
50.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
50.00Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
50.00Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
47.06Single8X5YAstemizole8X5Y-H1-Astemizole
46.67Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
46.67Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
46.67Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
46.67Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
46.67Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
46.67Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
46.67Single6TQ7SB-3348676TQ7-OX1-SB-334867
46.67Single7B6WCyclazosin7B6W-α1b-Cyclazosin
46.67Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
46.67Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
46.67Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
46.67Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
46.67Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
46.67Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
46.67Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
46.67Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
46.67Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
46.67Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
46.67Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
46.67Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
46.67Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
46.67Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
46.67Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
46.67Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
46.67Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
46.67Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
46.67Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
46.15Single3RZECidoxepin3RZE-H1-Cidoxepin
46.15Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
46.15Single4MBSMaraviroc4MBS-CCR5-Maraviroc
46.15Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
46.15Single6PS0S-Carazolol6PS0-β2-S-Carazolol
46.15Single6PS4ICI118-5516PS4-β2-ICI118-551
46.15Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
46.15Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
46.15Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
46.15Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
46.15Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
46.15Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
46.15Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
46.15Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
46.15Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
46.15Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
46.15Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
46.15Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
46.15Single7UL3Famotidine7UL3-H2-Famotidine
46.15Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
46.15Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.15Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
46.15Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
46.15Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
46.15Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
46.15Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
46.15Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
46.15Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
46.15Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.15Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
46.15Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
46.15Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
46.15Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
46.15Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
46.15Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.15Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.15Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
46.15Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.15Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.15Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.15Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
46.15Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
46.15Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
46.15Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
46.15Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
46.15Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
46.15Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
46.15Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
46.15Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
46.15Consensusalpha1_onOrthosteric Ligandalpha1a_on
46.15Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
46.15Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
46.15Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
45.45Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
45.45Single7WC5Psilocin7WC5-5-HT2A-Psilocin
45.45Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
45.45Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
45.45Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
45.45Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
45.45Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
45.45Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
45.45Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
45.45Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
44.44Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
43.75Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
43.75Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
43.75Single6MXTSalmeterol6MXT-β2-Salmeterol
43.75Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
43.75Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
43.75Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
43.75Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
43.75Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
43.75Single8JJLOlodaterol8JJL-β2-Olodaterol
43.75Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
43.75Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
43.75Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
43.75Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
42.86Single2Y04Salbutamol2Y04-β1-Salbutamol
42.86Single3NY8ICI118-5513NY8-β2-ICI118-551
42.86Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
42.86Single4DAJTiotropium4DAJ-M3-Tiotropium
42.86Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
42.86Single4EJ4Naltrindole4EJ4-δ-Naltrindole
42.86Single4GBRS-Carazolol4GBR-β2-S-Carazolol
42.86Single4MQSIperoxo4MQS-M2-Iperoxo
42.86Single4U14Tiotropium4U14-M3-Tiotropium
42.86Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
42.86Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
42.86Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
42.86Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
42.86Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
42.86Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
42.86Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
42.86Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
42.86Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
42.86Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
42.86Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
42.86Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
42.86Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
42.86Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
42.86Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
42.86Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
42.86Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
42.86Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
42.86Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
42.86Single8JXRLSD8JXR-D1-LSD
42.86Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
42.86Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
42.86Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
42.86Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
42.86Single8X64Desloratadine8X64-H1-Desloratadine
42.86Single9CHXS-Carazolol9CHX-β2-S-Carazolol
42.86Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
42.86Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
42.86Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
42.86Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
42.86Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
42.86Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
42.86Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
42.86Consensusdopamine_offOrthosteric Ligandd2_off d3_off
42.86Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
42.86Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
42.86Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
42.86Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
41.67Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
41.67Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
41.67Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
41.67Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
41.67Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
41.67Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
41.67Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
41.67Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
41.67Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
41.67Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
41.67Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
41.18Single5X93K-87945X93-ETB-K-8794
41.18Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
41.18Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
41.18Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
41.18Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
41.18Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.18Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
41.18Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
41.18Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
41.18Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
40.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
40.00Single5C1MBU725C1M-μ-BU72
40.00Single5WIUNemonapride5WIU-D4-Nemonapride
40.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
40.00Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
40.00Single5XPRBosentan5XPR-ETB-Bosentan
40.00Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
40.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
40.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
40.00Single6TP6Filorexant6TP6-OX1-Filorexant
40.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
40.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
40.00Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
40.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
40.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
40.00Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
40.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
40.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
40.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
40.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
40.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
40.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
40.00Single8JXSPF-61428JXS-D1-PF-6142
40.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
40.00Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.00Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
40.00Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
40.00Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
40.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
40.00Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
40.00Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
40.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
40.00Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
40.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Consensustrace-amine_onOrthosteric Ligandta1_on
38.89Single3NY9ICI118-5513NY9-β2-ICI118-551
38.89Single5ZTYAM102575ZTY-CB2-AM10257
38.89Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
38.89Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
38.89Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
38.89Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Single6AKYMaraviroc6AKY-CCR5-Maraviroc
38.46Single6TODEMPA6TOD-OX1-EMPA-Na
38.46Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
38.46Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
38.46Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
38.46Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
38.46Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
38.46Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
38.46Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
38.46Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
38.46Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
38.46Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
38.46Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
38.46Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
38.46Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
38.46Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
38.46Single8IWESpermidine8IWE-TA9-Spermidine
38.46Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
38.46Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
38.46Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
38.46Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
38.46Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
38.46Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
38.46Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
38.46Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
38.46Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
38.46Consensusorexin_offOrthosteric Ligandox2_off ox1_off
38.46Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
37.50Single2YDVNECA2YDV-A2A-NECA
37.50Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
37.50Single4DJHJDTic4DJH-κ-JDTic
37.50Single4U15Tiotropium4U15-M3-Tiotropium
37.50Single4UHRCGS216804UHR-A2A-CGS21680
37.50Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
37.50Single5G53NECA5G53-A2A-NECA-Gs
37.50Single6E59L-7607356E59-NK1-L-760735
37.50Single6J20Aprepitant6J20-NK1-Aprepitant
37.50Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
37.50Single6OL9Tiotropium6OL9-M5-Tiotropium
37.50Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
37.50Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
37.50Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
37.50Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
37.50Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
37.50Single8E0GBU728E0G-μ-BU72
37.50Single8EA0Iperoxo8EA0-M3-Iperoxo
37.50Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
37.50Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
37.50Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
37.50Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
37.50Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
37.50Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
37.50Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
37.50Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
37.50Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
37.50Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
37.50Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
37.50Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
37.50Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
37.50Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
37.50Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
36.84Single4IARErgotamine4IAR-5-HT1B-Ergotamine
36.84Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
36.84Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
36.84Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
36.36Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
36.36Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
36.36Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
36.36Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
36.36Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
36.36Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
35.71Single2YDOAdenosine2YDO-A2A-Adenosine
35.71Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
35.71Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
35.71Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
35.71Single4ZJCSB-6740424ZJC-OX1-SB-674042
35.71Single6A94Zotepine6A94-5-HT2A-Zotepine
35.71Single6KUXRS-799486KUX-α2a-RS-79948
35.71Single6TP3Nemorexant6TP3-OX1-Nemorexant
35.71Single6TPGEMPA6TPG-OX2-EMPA
35.71Single6TPNHTL66416TPN-OX2-HTL6641
35.71Single6VI4JDTic6VI4-κ-JDTic
35.71Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
35.71Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
35.71Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
35.71Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
35.71Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
35.71Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
35.71Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
35.71Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.71Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
35.71Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
35.71Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
35.71Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
35.71Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
35.71Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
35.71Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
35.71Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
35.71Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
35.71Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
35.71Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
35.71Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
35.71Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
35.71Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
35.71Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
35.71Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
35.29Single4RWADIPP-NH24RWA-δ-DIPP-NH2
35.29Single5CXVTiotropium5CXV-M1-Tiotropium
35.29Single6CM4Risperidone6CM4-D2-Risperidone
35.29Single6ZG4HTL00099366ZG4-M1-HTL0009936
35.29Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
35.29Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
35.29Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
35.29Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
35.29Single7YITNalfurafine7YIT-κ-Nalfurafine
35.29Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
35.29Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
35.29Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
35.29Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
35.29Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
35.29Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
35.29Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
35.29Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
35.29Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
35.29Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
35.29Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
35.29Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
35.29Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
35.29Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
35.29Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
35.29Consensusorexin_onOrthosteric Ligandox2_on
35.29Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
35.29Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
35.29Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
35.29Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
35.29Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
35.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
35.00Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
33.33Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
33.33Single2Y01Dobutamine2Y01-β1-Dobutamine
33.33Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
33.33Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
33.33Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
33.33Single5DHGC-355DHG-NOP-C-35
33.33Single5DHHSB-6121115DHH-NOP-SB-612111
33.33Single5DSGTiotropium5DSG-M4-Tiotropium
33.33Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
33.33Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
33.33Single6TOTLemborexant6TOT-OX1-Lemborexant
33.33Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
33.33Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
33.33Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
33.33Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
33.33Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
33.33Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
33.33Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
33.33Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
33.33Single7UL4Alvimopan7UL4-μ-Alvimopan
33.33Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
33.33Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
33.33Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
33.33Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
33.33Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
33.33Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
33.33Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
33.33Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
33.33Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
33.33Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
33.33Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
33.33Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
33.33Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
33.33Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
33.33Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
33.33Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
33.33Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
33.33Single8RLNLUF58348RLN-A2A-LUF5834
33.33Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
33.33Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
33.33Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
33.33Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
33.33Single8XVJMacitentan8XVJ-ETA-Macitentan
33.33Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
33.33Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
33.33Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
33.33Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
33.33Consensusa3_onOrthosteric Liganda3a_on
33.33Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
33.33Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
33.33Consensusendothelin_offOrthosteric Ligandetb_off
33.33Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
33.33Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
33.33Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
33.33Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
33.33Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
33.33Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
33.33Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
31.82Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
31.58Single4UG2CGS216804UG2-A2A-CGS21680
31.58Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
31.58Single6PT3DPI-2876PT3-δ-DPI-287
31.58Single7XN9L-054,5227XN9-SST2-L-054,522
31.58Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
31.58Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
31.58Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
31.58Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
31.58Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
31.58Consensuskisspeptin_onOrthosteric Ligandkiss1_on
31.58Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
31.58Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
31.25Single2Y00Dobutamine2Y00-β1-Dobutamine
31.25Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
31.25Single5WQCEMPA5WQC-OX2-EMPA
31.25Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
31.25Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
31.25Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
31.25Single7C4SS1P7C4S-S1P3-S1P
31.25Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
31.25Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
31.25Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
31.25Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
31.25Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
31.25Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
31.25Single7W41PD1762527W41-BB2-PD176252
31.25Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
31.25Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
31.25Single8S4DCMF-0198S4D-Apelin-CMF-019
31.25Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
31.25Single8TF5Oleic acid8TF5-GPR6-Oleic acid
31.25Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
31.25Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
31.25Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
31.25Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
31.25Consensusa3_on_gpOrthosteric Liganda3a_on_gp
31.25Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
31.25Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
31.25Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
31.25Consensusbombesin_offOrthosteric Ligandbb2_off
31.25Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
31.25Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
31.25Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
30.77Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
30.77Single3PBLEticlopride3PBL-D3-Eticlopride
30.77Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
30.77Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
30.77Single6HLLCP999946HLL-NK1-CP99994
30.77Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
30.77Single6TP4ACT-4622066TP4-OX1-ACT-462206
30.77Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
30.77Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
30.77Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
30.77Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
30.77Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
30.77Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
30.77Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
30.77Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
30.77Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
30.77Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
30.77Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
30.77Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
30.77Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
30.77Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
30.43Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
30.43Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
30.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
30.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
30.00Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
30.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
30.00Single8WDTphotoNECA8WDT-A2A-photoNECA
30.00Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.00Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
30.00Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
30.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
30.00Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
30.00Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
30.00Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
30.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
30.00Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
30.00Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
29.41Single5XR8AM8415XR8-CB1-AM841
29.41Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
29.41Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
29.41Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
29.41Single6J21Aprepitant6J21-NK1-Aprepitant
29.41Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
29.41Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
29.41Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
29.41Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
29.41Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
29.41Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
29.41Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
29.41Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
29.41Single7TUYGSK682753A7TUY-GPR183-GSK682753A
29.41Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
29.41Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
29.41Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
29.41Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
29.41Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
29.41Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
29.41Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
29.41Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
29.41Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
29.41Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
29.41Single8XVLZibotentan8XVL-ETA-Zibotentan
29.41Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
29.41Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
29.41Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
29.41Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
29.41Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
29.41Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
29.41Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
29.41Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
29.41Consensustachykinin_offOrthosteric Ligandnk1_off
29.17Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
29.17Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
28.57Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
28.57Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
28.57Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
28.57Single3QAKUK-4320973QAK-A2A-UK-432097
28.57Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
28.57Single4S0VSuvorexant4S0V-OX2-Suvorexant
28.57Single5WS3EMPA5WS3-OX2-EMPA
28.57Single6B73MP11046B73-κ-MP1104
28.57Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
28.57Single6HLOAprepitant6HLO-NK1-Aprepitant
28.57Single6TPJSuvorexant6TPJ-OX2-Suvorexant
28.57Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
28.57Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
28.57Single7F8ULintitript7F8U-CCKA-Lintitript
28.57Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
28.57Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
28.57Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
28.57Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
28.57Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
28.57Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
28.57Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
28.57Single7XRRLemborexant7XRR-OX2-Lemborexant
28.57Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
28.57Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
28.57Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
28.57Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
28.57Single8GNGIstradefylline8GNG-A2A-Istradefylline
28.57Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
28.57Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
28.57Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
28.57Single8Y0HVUF114188Y0H-CXCR3-VUF11418
28.57Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
28.57Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
28.57Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
28.57Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
28.57Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
28.57Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
28.57Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
28.57Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
28.57Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
28.00Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
28.00Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
28.00Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
28.00Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
27.78Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
27.78Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
27.78Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
27.78Single6A93Risperidone6A93-5-HT2A-Risperidone
27.78Single7DFPSpiperone7DFP-D2-Spiperone
27.78Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
27.78Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
27.78Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
27.78Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
27.78Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
27.78Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
27.78Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
27.78Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
27.78Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
27.78Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
27.78Single8JWY2-1188JWY-A2A-2-118
27.78Single8JWZAB9288JWZ-A2A-AB928-Na
27.78Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
27.78Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
27.78Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
27.78Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
27.78Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
27.78Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
27.78Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
27.78Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
27.78Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
27.78Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
27.78Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
27.78Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
27.78Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
27.78Consensuslpa_offOrthosteric Ligandlpa1_off
27.78Consensuslpl_offOrthosteric Ligands1p_off lpa_off
27.27Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
27.27Single5WF5UK-4320975WF5-A2A-UK-432097
27.27Single6PT2KGCHM076PT2-δ-KGCHM07
27.27Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
27.27Single8PWNTheophylline8PWN-A2A-Theophylline
27.27Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
27.27Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
27.27Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
27.27Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
27.27Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
27.27Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
26.92Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
26.67Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
26.67Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
26.67Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
26.67Single6IQLL7458706IQL-D4-L745870
26.67Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
26.67Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
26.67Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
26.67Single6TPKRetosiban6TPK-OT-Retosiban
26.67Single6V9SGTPL114036V9S-OX1-GTPL11403
26.67Single7AROLUF58337ARO-A2A-LUF5833-Na
26.67Single7VODCariprazine7VOD-5-HT2A-Cariprazine
26.67Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
26.67Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
26.67Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
26.67Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
26.67Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
26.67Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
26.67Single8IHKAcifran8IHK-HCA3-Acifran
26.67Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
26.67Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
26.67Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
26.67Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
26.67Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
26.67Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
26.67Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
26.67Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single9BJKNaloxone9BJK-μ-Naloxone-NAM
26.67Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
26.67Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
26.67Consensusopsins_offOrthosteric Ligandrhodopsin_off
26.67Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
26.67Consensussensory_offOrthosteric Ligandopsins_off
26.67Consensusvasop-oxy_offOrthosteric Ligandot_off
26.32Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.32Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
26.32Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
26.32Single6K1QIRL25006K1Q-ETB-IRL2500
26.32Single7EZCUKA7EZC-A2A-UKA
26.32Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
26.32Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.32Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
26.32Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
26.32Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
26.32Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.32Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
26.32Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
26.32Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
26.32Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
26.09Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
26.09Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
26.09Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
26.09Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
26.09Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
26.09Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
26.09Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
26.09Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
26.09Consensusvasop-oxy_onOrthosteric Ligandv2_on
26.09Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
25.93Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
25.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
25.00Single3RFMCaffeine3RFM-A2A-Caffeine
25.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
25.00Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
25.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
25.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
25.00Single5UENDU1725UEN-A1-DU172
25.00Single5UIGCmpd-15UIG-A2A-Cmpd-1
25.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
25.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
25.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
25.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
25.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
25.00Single7SK9CCX6627SK9-ACKR3-CCX662
25.00Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
25.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
25.00Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
25.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
25.00Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
25.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
25.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
25.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
25.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
25.00Single8CU6LJ-45178CU6-A2A-LJ-4517
25.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
25.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
25.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
25.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
25.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
25.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
25.00Single8QJ2pN1628QJ2-MC4-pN162-Gs
25.00Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
25.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
25.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
25.00Single8T1WCVN4248T1W-GPR6-CVN424
25.00Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
25.00Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
25.00Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
25.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
25.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
25.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
25.00Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
25.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
25.00Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
25.00Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
25.00Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
25.00Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
23.81Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
23.81Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
23.81Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
23.81Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
23.81Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
23.81Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
23.81Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
23.81Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
23.81Single8IEBA1LYA8IEB-GPR156-A1LYA
23.81Single8WKYPG-9348WKY-MC4-PG-934
23.81Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
23.81Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
23.81Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
23.81Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
23.81Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
23.81Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
23.81Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
23.81Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.53Single4NTJAZD12834NTJ-P2Y12-AZD1283
23.53Single5CGCHTL142425CGC-mGlu5-HTL14242
23.53Single5N2RPSB-365N2R-A2A-PSB-36-Na
23.53Single5N2SPSB365N2S-A1-PSB36
23.53Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
23.53Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
23.53Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
23.53Single6D26Fevipiprant6D26-DP2-Fevipiprant
23.53Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
23.53Single6HLPNetupitant6HLP-NK1-Netupitant
23.53Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
23.53Single6LUQHaloperidol6LUQ-D2-Haloperidol
23.53Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
23.53Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
23.53Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
23.53Single7SINNPS-21437SIN-CaS-NPS-2143
23.53Single7SINNPS-21437SIN-CaS-NPS-2143
23.53Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.53Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.53Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
23.53Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
23.53Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
23.53Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
23.53Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
23.53Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
23.53Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
23.53Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
23.53Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
23.53Single8ZMFA1L108ZMF-5-HT2C-A1L10
23.53Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
23.53Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
23.53Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
23.53Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
23.53Consensusadenosine_offOrthosteric Liganda1_off a2_off
23.53Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
23.53Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
23.53Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
23.53Consensusdp_offOrthosteric Liganddp2_off
23.53Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.53Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.53Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.53Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.53Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
23.08Single3UZAGTPL92363UZA-A2A-GTPL9236
23.08Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
23.08Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
23.08Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
23.08Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
23.08Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
23.08Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
23.08Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
23.08Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
23.08Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
23.08Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
23.08Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
23.08Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
23.08Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
23.08Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
23.08Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
22.73Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
22.73Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
22.73Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
22.73Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
22.73Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
22.22Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
22.22Single5V54Methiothepin5V54-5-HT1B-Methiothepin
22.22Single5XRAAM115425XRA-CB1-AM11542
22.22Single6IGLIRL16206IGL-ETB-IRL1620
22.22Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
22.22Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
22.22Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
22.22Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
22.22Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
22.22Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
22.22Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
22.22Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
22.22Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
22.22Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
22.22Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
22.22Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
22.22Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
22.22Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
22.22Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
22.22Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
22.22Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
22.22Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
22.22Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
22.22Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
22.22Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
22.22Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
22.22Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensus5ht1_offOrthosteric Ligand5ht1b_off
22.22Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
22.22Consensusa2_onOrthosteric Liganda2b_on
22.22Consensusa2_on_gpOrthosteric Liganda2b_on_gp
22.22Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
22.22Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
22.22Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
22.22Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
22.22Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
22.22Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
22.22Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
22.22Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
22.22Consensuslpa_onOrthosteric Ligandlpa1_on
22.22Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
22.22Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
21.74Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
21.74Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
21.74Single6W25SHU91196W25-MC4-SHU9119-Ca
21.74Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
21.74Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
21.74Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
21.74Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
21.74Consensusangiotensin_onOrthosteric Ligandat1_on
21.74Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
21.74Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
21.43Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
21.43Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
21.43Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
21.43Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
21.43Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
21.43Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
21.43Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
21.43Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
21.43Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
21.43Single8K5BNiacin8K5B-HCA2-Niacin
21.43Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
21.43Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
21.43Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
21.43Single9B9Y7DY9B9Y-CB1-7DY
21.43Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
21.43Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
21.43Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
21.43Consensusbombesin_onOrthosteric Ligandbb2_on
21.43Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
21.43Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
21.43Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
21.43Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
21.43Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
21.43Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
21.05Single4N4WSANT-14N4W-SMO-SANT-1
21.05Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
21.05Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
21.05Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
21.05Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
21.05Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
21.05Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
21.05Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
21.05Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
21.05Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
21.05Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
21.05Single8XYIVUF106618XYI-CXCR3-VUF10661
21.05Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
21.05Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
21.05Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
21.05Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
20.83Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
20.83Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
20.83Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
20.83Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.83Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
20.83Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
20.83Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
20.83Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.83Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.83Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
20.83Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.83Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.83Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
20.83Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
20.83Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
20.83Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
20.83Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
20.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
20.00Single3PWHZM-2413853PWH-A2A-ZM-241385
20.00Single5CGDHTL142425CGD-mGlu5-HTL14242
20.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
20.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
20.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
20.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
20.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
20.00Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
20.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
20.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
20.00Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
20.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
20.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
20.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
20.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
20.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
20.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
20.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
20.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
20.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
20.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
20.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
20.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
20.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
20.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
20.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
20.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
20.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
20.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
20.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
20.00Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
20.00Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
20.00Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.00Single8ZRTET-18ZRT-ETB-ET-1
20.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
20.00Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
20.00Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
20.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
20.00Consensusangiotensin_offOrthosteric Ligandat1_off
20.00Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
20.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
20.00Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
20.00Consensuschemerin_onOrthosteric Ligandcml1_on
20.00Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
20.00Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.00Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
20.00Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
20.00Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusprostanoid_offOrthosteric Ligandep_off dp_off
20.00Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
20.00Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
20.00Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.00Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
19.35Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
19.23Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
19.23Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
19.23Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
19.23Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
19.23Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
19.23Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
19.05Single5EE7MK08935EE7-Glucagon-MK0893
19.05Single5WF6UK-4320975WF6-A2A-UK-432097
19.05Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
19.05Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
19.05Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
19.05Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
19.05Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
19.05Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
19.05Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
19.05Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
19.05Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
19.05Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
19.05Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
19.05Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
19.05Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
19.05Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
19.05Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
18.75Single3REYXAC3REY-A2A-XAC
18.75Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
18.75Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
18.75Single5IU7Q274563465IU7-A2A-Q27456346-Na
18.75Single5IUBQ274563445IUB-A2A-Q27456344-Na
18.75Single5JTBZM-2413855JTB-A2A-ZM-241385
18.75Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
18.75Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
18.75Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
18.75Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
18.75Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
18.75Single6AQFZM-2413856AQF-A2A-ZM-241385
18.75Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
18.75Single6MH8ZM-2413856MH8-A2A-ZM-241385
18.75Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
18.75Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
18.75Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
18.75Single6ZG9GSK10347026ZG9-M1-GSK1034702
18.75Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
18.75Single7T32ZM-2413857T32-A2A-ZM-241385
18.75Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
18.75Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
18.75Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
18.75Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
18.75Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
18.75Single8K5CAcipimox8K5C-HCA2-Acipimox
18.75Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
18.75Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
18.75Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
18.75Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
18.75Consensusa2_offOrthosteric Liganda2a_off
18.75Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
18.75Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
18.75Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
18.75Consensusgrh_offOrthosteric Ligandgnrh1_off
18.75Consensushca_onOrthosteric Ligandhca2_on
18.75Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
18.52Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
18.52Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
18.52Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
18.52Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
18.18Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
18.18Single7F8XNN90567F8X-CCKA-NN9056
18.18Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
18.18Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
18.18Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
18.18Single8KIGSHU91198KIG-MC3-SHU9119-Ca
18.18Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
18.18Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
18.18Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
18.18Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
17.86Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
17.86Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
17.86Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
17.86Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
17.86Consensusbradykinin_onOrthosteric Ligandbk2_on
17.86Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
17.86Consensusendothelin_onOrthosteric Ligandetb_on eta_on
17.86Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
17.65Single3EMLZM-2413853EML-A2A-ZM-241385
17.65Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
17.65Single4YAYZD-71554YAY-AT1-ZD-7155
17.65Single5IU8Q274563475IU8-A2A-Q27456347-Na
17.65Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
17.65Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
17.65Single5TGZAM65385TGZ-CB1-AM6538
17.65Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
17.65Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
17.65Single6D27CAY104716D27-DP2-CAY10471
17.65Single6GPSMK08126GPS-CCR2-MK0812
17.65Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
17.65Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
17.65Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
17.65Single6S0LZM-2413856S0L-A2A-ZM-241385
17.65Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
17.65Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
17.65Single7F83PF-051904577F83-Ghrelin-PF-05190457
17.65Single7PYRPSB-21157PYR-A2A-PSB-2115
17.65Single7V3ZCP559407V3Z-CB1-CP55940
17.65Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
17.65Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
17.65Single7YXAONO-54306087YXA-S1P5-ONO-5430608
17.65Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
17.65Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
17.65Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
17.65Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
17.65Single8K5DGSK2560738K5D-HCA2-GSK256073
17.65Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
17.65Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
17.65Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
17.65Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
17.65Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
17.65Consensusblt_onOrthosteric Ligandblt1_on
17.65Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
17.65Consensuscck_offOrthosteric Ligandccka_off
17.65Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
17.65Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
17.65Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
17.65Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
17.65Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
17.65Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
17.65Consensushca_on_gpOrthosteric Ligandhca2_on_gp
17.65Consensusleukotriene_onOrthosteric Ligandblt_on
17.65Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
17.39Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
17.39Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
17.39Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
17.39Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
17.39Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
17.39Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
17.39Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
17.39Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
17.39Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
17.39Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
17.39Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
17.39Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.39Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
17.39Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
17.39Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.39Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
17.39Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
17.39Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
17.39Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
17.24Single5GLHEndothelin-15GLH-ETB-Endothelin-1
17.24Single6IGKEndothelin-36IGK-ETB-Endothelin-3
17.24Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
17.24Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
16.67Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
16.67Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
16.67Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
16.67Single5IUAQ274563485IUA-A2A-Q27456348-Na
16.67Single6GPXMK08126GPX-CCR2-MK0812
16.67Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
16.67Single6S0QZM-2413856S0Q-A2A-ZM-241385
16.67Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
16.67Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
16.67Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
16.67Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
16.67Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
16.67Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
16.67Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.67Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
16.67Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
16.67Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
16.67Single8GNEKW-63568GNE-A2A-KW-6356-Na
16.67Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
16.67Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
16.67Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
16.67Single8QOTNanobody-E8QOT-μ-Nanobody-E
16.67Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
16.67Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
16.67Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
16.67Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
16.67Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.67Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
16.67Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
16.67Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
16.67Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
16.67Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
16.67Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
16.67Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
16.67Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
16.67Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
16.67Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
16.67Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.67Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
16.67Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
16.67Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
16.67Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
16.67Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
16.67Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
16.67Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
16.67Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
16.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
16.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
16.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
16.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
16.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
16.00Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
16.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
16.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
16.00Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
16.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
16.00Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.00Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
16.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
15.79Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
15.79Single7FEECP559407FEE-CB1-CP55940-ZCZ011
15.79Single7P2L4YI7P2L-mGlu5-4YI
15.79Single7PX4PSB-21137PX4-A2A-PSB-2113
15.79Single7R0CAVP7R0C-V2-AVP-Arrestin2
15.79Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
15.79Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
15.79Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
15.79Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
15.79Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
15.79Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
15.79Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
15.79Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
15.79Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
15.79Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
15.79Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
15.79Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.79Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
15.79Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
15.79Single9BJKNAM9BJK-μ-Naloxone-NAM
15.79Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
15.79Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
15.79Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
15.79Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
15.79Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
15.38Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
15.38Single3OE8IT1t3OE8-CXCR4-IT1t
15.38Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
15.38Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
15.38Single6TQ9SB-4081246TQ9-OX1-SB-408124
15.38Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
15.38Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
15.38Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
15.38Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
15.38Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
15.38Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
15.38Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
15.38Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
15.38Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
15.38Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
15.38Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
15.38Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
15.38Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
15.38Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
15.38Consensussensory_onOrthosteric Ligandopsins_on
15.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
15.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
15.00Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
15.00Single6KQICP559406KQI-CB1-CP55940-Org27569
15.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
15.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
15.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
15.00Single7K15MKD0467K15-BLT1-MKD046-Na
15.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
15.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
15.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
15.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
15.00Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
15.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
15.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
15.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
15.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
15.00Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
15.00Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
15.00Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
15.00Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
15.00Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
14.81Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
14.81Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
14.81Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
14.81Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
14.81Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
14.71Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
14.71Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
14.29Single3OE6IT1t3OE6-CXCR4-IT1t
14.29Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
14.29Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
14.29Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
14.29Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
14.29Single6ME5Agomelatine6ME5-MT1-Agomelatine
14.29Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
14.29Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
14.29Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
14.29Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
14.29Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
14.29Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
14.29Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
14.29Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
14.29Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
14.29Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
14.29Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
14.29Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
14.29Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
14.29Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
14.29Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
14.29Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
14.29Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
14.29Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
14.29Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.29Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
14.29Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
14.29Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
14.29Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
14.29Consensusgi_sensoryOrthosteric Ligandgi_opsins
14.29Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
14.29Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
14.29Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
14.29Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
14.29Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
14.29Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
14.29Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
14.29Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
14.29Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
13.79Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
13.79Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
13.79Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
13.79Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
13.79Single8IY6Endothelin-18IY6-ETB-Endothelin-1
13.79Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
13.79Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
13.64Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
13.64Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
13.64Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
13.64Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
13.64Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
13.64Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
13.64Single8IEIA1LYA8IEI-GPR156-A1LYA
13.64Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
13.64Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
13.64Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
13.64Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
13.64Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
13.33Single3OE9IT1t3OE9-CXCR4-IT1t
13.33Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
13.33Single6LI0C176LI0-GPR52-C17
13.33Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
13.33Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
13.33Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
13.33Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
13.33Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
13.33Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
13.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
13.33Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
13.33Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
13.33Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
13.33Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
13.33Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
13.04Single4XT1Fractalkine4XT1-US28-Fractalkine
13.04Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
13.04Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
13.04Single7QA8Peptide7QA8-STE2-Peptide
13.04Single7QA8Peptide7QA8-STE2-Peptide
13.04Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
13.04Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
13.04Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
13.04Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
13.04Single8IEIA1LYA8IEI-GPR156-A1LYA
13.04Single8IEPA1LYA8IEP-GPR156-A1LYA
13.04Single8IEPA1LYA8IEP-GPR156-A1LYA
13.04Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
13.04Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
12.90Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
12.90Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
12.90Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
12.50Single3ODUIT1t3ODU-CXCR4-IT1t
12.50Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
12.50Single5U09Taranabant5U09-CB1-Taranabant
12.50Single5ZKQABT-4915ZKQ-PAF-ABT-491
12.50Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
12.50Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
12.50Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
12.50Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
12.50Single7F8YDevazepide7F8Y-CCKA-Devazepide
12.50Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
12.50Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
12.50Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
12.50Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
12.50Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
12.50Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
12.50Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
12.50Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
12.50Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
12.50Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
12.50Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
12.50Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
12.50Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8IEBA1LYA8IEB-GPR156-A1LYA
12.50Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
12.50Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
12.50Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
12.50Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
12.50Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
12.50Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
12.50Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
12.50Single9BA0A1AKN9BA0-CB1-A1AKN
12.50Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
12.50Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
12.50Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
12.12Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
12.12Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
12.12Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.00Single3OE0CVX153OE0-CXCR4-CVX15
12.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
12.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
12.00Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
12.00Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.00Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.76Single5UVIZM-2413855UVI-A2A-ZM-241385
11.76Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
11.76Single6FFIMMPEP6FFI-mGlu5-MMPEP
11.76Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
11.76Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
11.76Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
11.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.76Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
11.76Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
11.76Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
11.76Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
11.76Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
11.76Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
11.76Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
11.76Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
11.54Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
11.54Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
11.54Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
11.54Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
11.54Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
11.54Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
11.54Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
11.54Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
11.54Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
11.54Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
11.11Single4QIMANTA XV4QIM-SMO-ANTA XV
11.11Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
11.11Single6FFHFenobam6FFH-mGlu5-Fenobam
11.11Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
11.11Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
11.11Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
11.11Single6IIVDaltroban6IIV-TP-Daltroban
11.11Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
11.11Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
11.11Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
11.11Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
11.11Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
11.11Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
11.11Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
11.11Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
11.11Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
11.11Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
11.11Single9B9ZA1AKO9B9Z-CB1-A1AKO
11.11Single9IYAONO-97105319IYA-GPR55-ONO-9710531
11.11Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
11.11Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
11.11Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
11.11Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
11.11Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
10.71Single4XT3Fractalkine4XT3-US28-Fractalkine
10.71Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
10.71Single6FJ3PTH6FJ3-PTH1-PTH
10.71Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
10.71Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
10.71Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
10.71Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
10.71Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
10.71Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
10.71Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
10.71Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
10.71Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
10.71Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
10.71Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
10.71Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
10.53Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
10.53Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
10.53Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
10.53Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
10.53Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.53Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
10.53Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
10.53Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
10.53Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.53Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
10.53Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
10.53Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
10.53Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
10.53Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
10.53Consensusblt_offOrthosteric Ligandblt1_off
10.53Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.53Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
10.53Consensusep_offOrthosteric Ligandep4_off
10.53Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
10.53Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
10.34Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
10.34Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
10.34Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
10.34Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
10.34Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
10.34Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
10.34Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
10.34Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
10.34Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
10.34Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
10.00Single5TZRMK86665TZR-FFA1-MK8666
10.00Single5V56TC1145V56-SMO-TC114
10.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
10.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
10.00Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
10.00Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
10.00Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
10.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
10.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
10.00Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
10.00Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
10.00Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
10.00Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
10.00Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
10.00Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
10.00Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
10.00Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
10.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
10.00Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
10.00Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
9.68Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
9.68Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
9.52Single4PY02MeSATP4PY0-P2Y12-2MeSATP
9.52Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
9.52Single5X33BIIL2605X33-BLT1-BIIL260
9.52Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
9.52Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
9.52Single6IIURamatroban6IIU-TP-Ramatroban
9.52Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
9.52Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
9.52Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
9.52Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
9.52Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
9.38Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
9.38Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
9.09Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
9.09Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
9.09Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
9.09Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
9.09Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
9.09Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
8.82Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
8.70Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
8.70Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
8.70Single8XQJJN2418XQJ-Apelin-JN241
8.70Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.70Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
8.70Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
8.70Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
8.33Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
8.33Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
8.33Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
8.33Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
8.33Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
8.33Consensussomatostatin_offOrthosteric Ligandsst2_off
8.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
8.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
8.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
8.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
8.00Single7SHEPI; PE7SHE-GPR158-PI; PE
8.00Single7SK5CXCL127SK5-ACKR3-CXCL12
8.00Single7XNACYN1548067XNA-SST2-CYN154806
8.00Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
7.89Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
7.69Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
7.69Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
7.69Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
7.69Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
7.69Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
7.69Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
7.69Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
7.69Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
7.69Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
7.41Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
7.41Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
7.14Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
7.14Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
7.14Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
7.14Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
7.14Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
7.14Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
7.14Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
7.14Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
7.14Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
7.14Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
6.90Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
6.90Single7SK3CXCL127SK3-ACKR3-CXCL12
6.90Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
6.90Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
6.90Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
6.67Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
6.67Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.67Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
6.67Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
6.67Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
6.67Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
6.67Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
6.67Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
6.67Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
6.67Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
6.67Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
6.67Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
6.45Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
6.45Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
6.25Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
6.25Single5L7IVismodegib5L7I-SMO-Vismodegib
6.25Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
6.25Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
6.25Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
6.25Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
6.25Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
6.25Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
6.06Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
6.06Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
5.88Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
5.88Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
5.88Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
5.88Single4XNVBPTU4XNV-P2Y1-BPTU
5.88Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
5.88Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
5.88Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
5.88Single7WV9ZCZ0117WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
5.88Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
5.88Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
5.71Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
5.71Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
5.56Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
5.56Single6ZINSR486926ZIN-NTS1-SR48692
5.56Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
5.56Single7VV6C48/807VV6-MRGPRX2-C48/80
5.56Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.56Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single8IYXYL-3658IYX-GPR34-YL-365
5.56Single8K2WAMG4878K2W-CXCR3-AMG487
5.56Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
5.56Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
5.56Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.26Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
5.26Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
5.26Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
5.26Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
5.26Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
5.26Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
5.00Single4JKVTaladegib4JKV-SMO-Taladegib
5.00Single6Z4SSR486926Z4S-NTS1-SR48692
5.00Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
5.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.76Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
4.76Single4BV0Neurotensin4BV0-NTS1-Neurotensin
4.76Single5V57TC1145V57-SMO-TC114
4.76Single6OS1TRV0266OS1-AT1-TRV026
4.76Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
4.76Single7F1TMIP-1a7F1T-CCR5-MIP-1a
4.76Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
4.76Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
4.76Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
4.76Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
4.76Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
4.76Consensusneurotensin_onOrthosteric Ligandnts1_on
4.76Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
4.55Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
4.55Single4XEENeurotensin4XEE-NTS1-Neurotensin
4.55Single4XESNeurotensin4XES-NTS1-Neurotensin
4.55Single6OS2TRV0266OS2-AT1-TRV026
4.55Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
4.55Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
4.55Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
4.55Single7SHEPI; PE7SHE-GPR158-PI; PE
4.55Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
4.55Single8XQJJN2418XQJ-Apelin-JN241
4.55Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
4.55Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
4.55Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
4.55Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
4.35Single4BUONeurotensin4BUO-NTS1-Neurotensin
4.35Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
4.35Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
4.35Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.35Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
4.35Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
4.35Single8XVUCXCL28XVU-CXCR2-CXCL2
4.35Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
4.17Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
4.17Single6KNMJN241-96KNM-Apelin-JN241-9
4.17Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
4.17Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
4.17Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
4.17Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
4.00Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
4.00Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
4.00Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
4.00Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.00Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
4.00Single8XWNCXCL88XWN-CXCR2-CXCL8
3.85Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.85Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
3.70Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
3.57Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
3.45Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
3.23Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
2.78Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2

Consensus Members
Id Members
7SRR 7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
Net Summary
Imin 2.39
Number of Linked Nodes 845
Number of Links 1031
Number of Hubs 159
Number of Links mediated by Hubs 601
Number of Communities 25
Number of Nodes involved in Communities 254
Number of Links involved in Communities 358
Path Summary
Number Of Nodes in MetaPath 111
Number Of Links MetaPath 110
Number of Shortest Paths 4510269
Length Of Smallest Path 3
Average Path Length 41.4212
Length of Longest Path 75
Minimum Path Strength 1.3
Average Path Strength 5.76275
Maximum Path Strength 21.76
Minimum Path Correlation 0.7
Average Path Correlation 0.991983
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.32558
Average % Of Corr. Nodes 27.7341
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 53.1869
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
5ht2b_off_on_gp5ht2b_on_gp5ht2b_off
This network is also present in following consensuses:
IdComponents
5ht2_on_gp5ht2b_on_gp



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 5ht2b_on_gp.zip



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