Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:M40 5.656516
2R:R:I47 3.66408
3R:R:L53 4.4725406
4R:R:I58 5.6175457
5R:R:F61 5.9406
6R:R:F71 5.328508
7R:R:L75 5.5875419
8R:R:D79 8.148519
9R:R:M82 5.4425417
10R:R:V86 5.096517
11R:R:V87 3.67417
12R:R:W99 9.2617
13R:R:W109 5.34515
14R:R:T118 6.585406
15R:R:L124 5.7225418
16R:R:Y132 7.985408
17R:R:F133 9.81425
18R:R:Y141 9.3475427
19R:R:W158 5.56409
20R:R:Y174 7.784535
21R:R:R175 16.8432
22R:R:F194 6.132541
23R:R:T195 4.24433
24R:R:Y199 5.89833636
25R:R:F208 9.922518
26R:R:F282 5.814519
27R:R:W286 8.18333618
28R:R:L287 4.5175406
29R:R:F289 11.112516
30R:R:F290 11.142517
31R:R:L311 3.4525405
32R:R:W313 8.6225415
33R:R:Y316 8.52857716
34R:R:N322 6.106519
35R:R:Y326 6.2519
36R:R:F332 9.02167659
37L:L:?1 9.941310
38W:W:?1 10.561020
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:M40 R:R:W313 17.166910.47YesYes165
2R:R:I43 R:R:I47 11.84792.94NoYes068
3R:R:W313 R:R:Y316 21.346614.47YesYes156
4R:R:M82 R:R:Y316 56.23824.79YesYes176
5R:R:M82 R:R:S319 73.12236.13YesNo079
6R:R:D79 R:R:S319 77.969811.78YesNo099
7R:R:D79 R:R:N51 81.34048.08YesNo099
8R:R:N51 R:R:P323 79.1096.52NoNo099
9R:R:P323 R:R:V54 76.8623.53NoNo099
10R:R:A76 R:R:V54 18.80113.39NoNo099
11R:R:A76 R:R:I55 16.16123.25NoNo097
12R:R:I55 R:R:L80 10.83444.28NoNo077
13R:R:C327 R:R:V54 58.32025.12NoNo079
14R:R:C327 R:R:F332 55.931818.15NoYes079
15R:R:F332 R:R:F336 31.50538.57YesNo097
16R:R:F336 R:R:L53 26.35928.53NoYes076
17R:R:L339 R:R:L53 15.90982.77NoYes066
18R:R:F61 R:R:L339 10.59086.09YesNo066
19R:R:D130 R:R:F71 79.6598.36NoYes088
20R:R:F71 R:R:I154 88.08145.02YesNo088
21R:R:I154 R:R:S74 96.158110.84NoNo089
22R:R:S74 R:R:T123 95.93026.4NoNo098
23R:R:L75 R:R:T123 1005.9YesNo098
24R:R:D79 R:R:L75 57.31466.79YesYes199
25R:R:D130 R:R:T68 10.40237.23NoNo088
26R:R:D79 R:R:N322 27.41996.73YesYes199
27R:R:N322 R:R:Y326 40.8474.65YesYes199
28R:R:S74 R:R:W158 27.32566.18NoYes099
29R:R:L124 R:R:L75 46.48025.54YesYes189
30R:R:L124 R:R:N322 15.76055.49YesYes189
31L:L:?1 R:R:Y316 94.98746.15YesYes106
32L:L:?1 R:R:F290 98.16947.99YesYes107
33R:R:F208 R:R:F290 73.020121.43YesYes187
34R:R:F208 R:R:F282 71.03244.29YesYes189
35R:R:F282 R:R:L124 69.61823.65YesYes198
36R:R:V86 R:R:Y316 30.40545.05YesYes176
37R:R:V86 R:R:W109 56.95322.45YesYes175
38R:R:W109 R:R:W99 38.33287.5YesYes157
39R:R:F101 R:R:W99 15.642715.03NoYes057
40R:R:F101 R:R:T100 11.75367.78NoNo052
41R:R:G102 R:R:W99 11.75362.81NoYes077
42R:R:I112 R:R:V86 15.67413.07NoYes047
43R:R:F108 R:R:I112 11.77723.77NoNo054
44R:R:E107 R:R:Y174 11.82437.86NoYes355
45R:R:T195 R:R:Y174 45.58453.75YesYes335
46R:R:F193 R:R:T195 52.3577.78NoYes043
47L:L:?1 R:R:F193 55.051821.56YesNo004
48R:R:Y174 R:R:Y199 89.58995.96YesYes356
49R:R:V114 R:R:Y199 56.35613.79NoYes056
50L:L:?1 R:R:V114 59.365212.7YesNo005
51R:R:S203 R:R:Y199 56.568211.45NoYes056
52L:L:?1 R:R:S203 59.3187.88YesNo005
53R:R:R175 R:R:Y174 98.89229.26YesYes325
54R:R:I169 R:R:Y174 34.985912.09NoYes055
55R:R:I169 R:R:S111 30.11479.29NoNo056
56R:R:F166 R:R:S111 24.8357.93NoNo046
57R:R:L115 R:R:W158 22.65875.69NoYes059
58R:R:F166 R:R:L115 19.14684.87NoNo645
59L:L:?1 R:R:V117 24.3955.86YesNo006
60R:R:F289 R:R:W286 27.34137.02YesYes168
61L:L:?1 R:R:F289 25.65219.58YesYes106
62R:R:V117 R:R:W286 23.91589.81NoYes068
63R:R:F290 R:R:W286 25.97426.01YesYes178
64R:R:E122 R:R:T118 13.78065.64NoYes056
65R:R:S207 R:R:T118 31.94539.59NoYes056
66L:L:?1 R:R:S207 36.44725.91YesNo005
67R:R:C125 R:R:M215 14.72344.86NoNo078
68R:R:F282 R:R:M215 48.279411.2YesNo098
69R:R:M279 R:R:Y219 23.17723.59NoNo089
70R:R:M215 R:R:M279 31.6865.78NoNo088
71R:R:D130 R:R:Y141 69.170311.49NoYes087
72R:R:F133 R:R:Y141 23.703611.35YesYes257
73R:R:Y141 W:W:?1 40.89416.34YesYes270
74R:R:F133 R:R:Y132 17.41046.19YesYes058
75R:R:R221 R:R:Y132 10.08018.23NoYes058
76R:R:I153 W:W:?1 12.88511.57NoYes060
77R:R:I153 R:R:V152 10.39441.54NoNo064
78R:R:P168 R:R:Y199 18.3146.95NoYes056
79R:R:L167 R:R:P168 13.75714.93NoNo055
80R:R:R175 R:R:Y185 86.816522.64YesNo021
81R:R:A181 R:R:Y185 80.98685.34NoNo041
82R:R:A181 R:R:H178 12.46867.32NoNo442
83R:R:A181 R:R:F194 62.37435.55NoYes441
84R:R:C184 R:R:F194 25.07074.19NoYes411
85R:R:C184 R:R:C190 18.82467.28NoNo413
86R:R:C190 R:R:D192 18.82466.22NoNo433
87R:R:D192 R:R:F194 25.07077.17NoYes431
88R:R:C190 R:R:E187 25.11793.04NoNo034
89R:R:E187 R:R:T189 12.562911.29NoNo044
90R:R:A200 R:R:T195 10.48871.68NoYes053
91R:R:F208 R:R:L287 53.58264.87YesYes086
92R:R:L275 R:R:Y219 17.42611.17NoNo089
93R:R:L272 R:R:L275 11.60434.15NoNo078
94R:R:I278 R:R:Y326 19.65743.63NoYes189
95R:R:I278 R:R:T274 14.69991.52NoNo088
96R:R:K270 R:R:T274 10.09599.01NoNo078
97R:R:I325 R:R:Y326 29.729710.88NoYes189
98R:R:I325 R:R:T281 24.79574.56NoNo086
99R:R:F321 R:R:T281 10.15873.89NoNo066
100R:R:N318 R:R:W286 65.66626.78NoYes098
101R:R:I291 R:R:L287 22.83167.14NoYes066
102R:R:L287 R:R:P288 22.83161.64YesNo069
103R:R:L311 R:R:P288 20.02674.93YesNo059
104R:R:I291 R:R:V295 19.99531.54NoNo064
105R:R:I47 R:R:S319 17.38694.64YesNo089
106R:R:M82 R:R:V86 18.60477.61YesYes177
107R:R:V87 R:R:Y316 14.16563.79YesYes176
108R:R:D113 R:R:V86 28.00917.3NoYes177
109R:R:N318 R:R:N322 59.4289.54NoYes099
110R:R:L124 R:R:Y326 18.32188.21YesYes189
111R:R:L75 R:R:N322 30.65684.12YesYes199
112L:L:?1 R:R:D113 28.810518.69YesNo107
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 7.61 1 Yes Yes 7 7 2 2
R:R:M82 R:R:Y316 4.79 1 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 7.3 1 No Yes 7 7 1 2
R:R:V86 R:R:Y316 5.05 1 Yes Yes 7 6 2 1
R:R:V87 R:R:W313 3.68 1 Yes Yes 7 5 2 2
R:R:V87 R:R:Y316 3.79 1 Yes Yes 7 6 2 1
L:L:?1 R:R:T110 3.87 1 Yes No 0 4 0 1
R:R:D113 R:R:Y316 11.49 1 No Yes 7 6 1 1
L:L:?1 R:R:D113 18.69 1 Yes No 0 7 0 1
R:R:V114 R:R:Y199 3.79 0 No Yes 5 6 1 2
L:L:?1 R:R:V114 12.7 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 9.81 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 5.86 1 Yes No 0 6 0 1
R:R:S207 R:R:T118 9.59 0 No Yes 5 6 1 2
R:R:F193 R:R:T195 7.78 0 No Yes 4 3 1 2
L:L:?1 R:R:F193 21.56 1 Yes No 0 4 0 1
R:R:T195 R:R:Y199 3.75 3 Yes Yes 3 6 2 2
R:R:S203 R:R:Y199 11.45 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 7.88 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 1 Yes No 7 5 1 2
L:L:?1 R:R:S207 5.91 1 Yes No 0 5 0 1
R:R:F208 R:R:F290 21.43 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 7.02 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 6.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 15 1 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 8.25 1 Yes No 6 5 1 2
R:R:F289 R:R:N312 15.71 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 9.58 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 7.99 1 Yes Yes 0 7 0 1
R:R:N293 R:R:Y308 8.14 0 No No 5 5 1 2
L:L:?1 R:R:N293 9 1 Yes No 0 5 0 1
R:R:I309 R:R:K305 5.82 0 No No 3 2 1 2
L:L:?1 R:R:I309 5.62 1 Yes No 0 3 0 1
R:R:N312 R:R:Y316 13.96 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 14.41 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 14.47 1 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 6.15 1 Yes Yes 0 6 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
92.86Single4LDEBI1671074LDE-β2-BI167107
85.71Single6H7JIsoprenaline6H7J-β1-Isoprenaline
85.71Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
85.71Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
85.71Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
84.62Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
84.62Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
84.62Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
84.62Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
84.62Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
84.62Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
84.62Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
84.62Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
84.62Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
84.62Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
84.62Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
84.62Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
84.62Single8GGJEpinephrine8GGJ-β2-Epinephrine
84.62Single8GGNEpinephrine8GGN-β2-Epinephrine
84.62Single8GGOEpinephrine8GGO-β2-Epinephrine
84.62Single8GGUEpinephrine8GGU-β2-Epinephrine
84.62Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
84.62Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
84.62Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
84.62Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
80.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
80.00Single8JJ8Formoterol8JJ8-β2-Formoterol
78.57Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
78.57Single2Y03Isoprenaline2Y03-β1-Isoprenaline
78.57Single6E67BI1671076E67-β2-BI167107-Gs (fused)
78.57Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
78.57Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
78.57Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
78.57Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
78.57Single7XKAEpinephrine7XKA-β2-Epinephrine
78.57Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
78.57Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
78.57Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
78.57Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
78.57Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
78.57Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
78.57Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
78.57Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
78.57Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
76.92Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
76.92Single6PS4ICI 118-5516PS4-β2-ICI 118-551
76.92Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
76.92Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
76.92Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
76.92Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
76.92Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
76.92Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
76.92Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
76.92Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
76.92Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
76.92Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
76.92Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
76.92Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8GGIEpinephrine8GGI-β2-Epinephrine
76.92Single8GGKEpinephrine8GGK-β2-Epinephrine
76.92Single8GGMEpinephrine8GGM-β2-Epinephrine
76.92Single8GGPEpinephrine8GGP-β2-Epinephrine
76.92Single8GGQEpinephrine8GGQ-β2-Epinephrine
76.92Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
75.00Single6H7LDobutamine6H7L-β1-Dobutamine
75.00Single6IBLArformoterol6IBL-β1-Arformoterol
73.33Single3P0GBI1671073P0G-β2-BI167107
73.33Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
73.33Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
73.33Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
73.33Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
73.33Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
73.33Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
73.33Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
73.33Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
73.33Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
73.33Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
73.33Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
71.43Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
71.43Single2Y04Salbutamol2Y04-β1-Salbutamol
71.43Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
71.43Single3NY8ICI 118-5513NY8-β2-ICI 118-551
71.43Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
71.43Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
71.43Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
71.43Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
71.43Single6H7MSalbutamol6H7M-β1-Salbutamol
71.43Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
71.43Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
71.43Single6PS1Timolol6PS1-β2-Timolol
71.43Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
71.43Single7BU7BI1671077BU7-β1-BI167107
71.43Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
71.43Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
71.43Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
71.43Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
71.43Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
71.43Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
71.43Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
71.43Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
71.43Single8JJOAlprenolol8JJO-β2-Alprenolol
71.43Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
71.43Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
71.43Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
71.43Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
71.43Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
71.43Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
71.43Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
69.23Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
69.23Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
69.23Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
69.23Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
69.23Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
69.23Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
69.23Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
69.23Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
69.23Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8GGVEpinephrine8GGV-β2-Epinephrine
69.23Single8GGWEpinephrine8GGW-β2-Epinephrine
69.23Single8GGXEpinephrine8GGX-β2-Epinephrine
69.23Single8GH0Epinephrine8GH0-β2-Epinephrine
69.23Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
68.75Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
68.75Single4AMIBucindolol4AMI-β1-Bucindolol
68.75Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
68.75Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
68.75Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
68.75Single6MXTSalmeterol6MXT-β2-Salmeterol
68.75Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
68.75Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
68.75Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
66.67Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
66.67Single4IARErgotamine4IAR-5-HT1B-Ergotamine
66.67Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
66.67Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
66.67Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
66.67Single7WC6LSD7WC6-5-HT2A-LSD
66.67Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
66.67Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
66.67Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
66.67Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
66.67Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
66.67Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
66.67Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
66.67Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
64.71Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
64.71Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
64.71Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
64.29Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
64.29Single6TPGEMPA6TPG-OX2-EMPA
64.29Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
64.29Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
64.29Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
64.29Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
64.29Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Single8GGLEpinephrine8GGL-β2-Epinephrine
64.29Single8GGTEpinephrine8GGT-β2-Epinephrine
64.29Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
64.29Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
64.29Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
64.29Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
64.29Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
64.29Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
62.50Single2YDVNECA2YDV-A2A-NECA
62.50Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
62.50Single4RWADIPP-NH24RWA-δ-DIPP-NH2
62.50Single4UHRCGS216804UHR-A2A-CGS21680
62.50Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
62.50Single5G53NECA5G53-A2A-NECA-Gs
62.50Single6TQ7SB-3348676TQ7-OX1-SB-334867
62.50Single6WGTLSD6WGT-5-HT2A-LSD
62.50Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
62.50Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
62.50Single8E0GBU728E0G-μ-BU72
62.50Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
62.50Consensus5ht5_offOrthosteric Ligand5ht5a_off
62.50Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
62.50Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
62.50Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
62.50Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
62.50Consensushistamine_offOrthosteric Ligandh1_off
61.54Single3PBLEticlopride3PBL-D3-Eticlopride
61.54Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
61.54Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
61.54Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
61.54Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
61.54Single8GGSEpinephrine8GGS-β2-Epinephrine
61.54Single8GGYEpinephrine8GGY-β2-Epinephrine
61.54Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
61.54Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
61.11Single3NY9PubChem 9131033NY9-β2-PubChem 913103
61.11Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
61.11Single8X5YAstemizole8X5Y-H1-Astemizole
60.00Single2Y01Dobutamine2Y01-β1-Dobutamine
60.00Single2Y02Carmoterol2Y02-β1-Carmoterol
60.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
60.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
60.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
60.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
60.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
60.00Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
60.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
60.00Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
60.00Single7UL4Alvimopan7UL4-μ-Alvimopan
60.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
60.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
60.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
60.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
60.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
60.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
60.00Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
60.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
60.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
60.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
60.00Single8X64Desloratadine8X64-H1-Desloratadine
60.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
60.00Consensustar_onOrthosteric Ligandta1_on
58.82Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
58.82Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
58.82Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
58.82Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
58.82Single7YITNalfurafine7YIT-κ-Nalfurafine
58.82Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
58.82Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
58.82Single8JJLOlodaterol8JJL-β2-Olodaterol
58.82Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
58.82Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
58.82Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
57.89Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
57.14Single6KUXRS-799486KUX-α2a-RS-79948
57.14Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
57.14Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
57.14Single6TODEMPA6TOD-OX1-EMPA-Na
57.14Single7C61Ergotamine7C61-5-HT1B-Ergotamine
57.14Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
57.14Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
57.14Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
57.14Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
57.14Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
57.14Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
57.14Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
57.14Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
57.14Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
57.14Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
57.14Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
57.14Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
57.14Consensusalpha1_onOrthosteric Ligandalpha1a_on
57.14Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
57.14Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
57.14Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
57.14Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
57.14Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
57.14Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
56.25Single2Y00Dobutamine2Y00-β1-Dobutamine
56.25Single5C1MBU725C1M-μ-BU72
56.25Single5TVNLSD5TVN-5-HT2B-LSD
56.25Single5WIUNemonapride5WIU-D4-Nemonapride
56.25Single5WIVNemonapride5WIV-D4-Nemonapride-Na
56.25Single5WQCEMPA5WQC-OX2-EMPA
56.25Single6PS6Timolol6PS6-β2-Timolol
56.25Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
56.25Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
56.25Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
56.25Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
56.25Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
56.25Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
56.25Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
56.25Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
55.56Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
55.56Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
55.56Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
55.56Single7UM4AS26747237UM4-5-HT5A-AS2674723
55.56Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
55.56Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
55.56Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
55.56Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
55.56Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
55.56Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
55.56Consensusendothelin_offOrthosteric Ligandetb_off
55.56Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
55.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
53.85Single8GGREpinephrine8GGR-β2-Epinephrine
53.85Single8GGZEpinephrine8GGZ-β2-Epinephrine
53.85Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
53.33Single4ZJCSB-6740424ZJC-OX1-SB-674042
53.33Single6A94Zotepine6A94-5-HT2A-Zotepine
53.33Single6TPNHTL66416TPN-OX2-HTL6641
53.33Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
53.33Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
53.33Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
53.33Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
53.33Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
53.33Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
53.33Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
53.33Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
53.33Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
53.33Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
53.33Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
53.33Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
53.33Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
53.33Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.33Consensus5ht5_onOrthosteric Ligand5ht5a_on
53.33Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
53.33Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
53.33Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
53.33Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
53.33Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
52.94Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
52.94Single4U15Tiotropium4U15-M3-Tiotropium
52.94Single5X93K-87945X93-ETB-K-8794
52.94Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
52.94Single6J20Aprepitant6J20-NK1-Aprepitant
52.94Single6J21Aprepitant6J21-NK1-Aprepitant
52.94Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
52.94Single6OL9Tiotropium6OL9-M5-Tiotropium
52.94Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
52.94Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
52.94Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
52.94Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
52.94Consensusa2_onOrthosteric Liganda2a_on a2b_on
52.94Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
52.94Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
52.94Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
52.63Single4UG2CGS216804UG2-A2A-CGS21680
50.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
50.00Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
50.00Single5CXVTiotropium5CXV-M1-Tiotropium
50.00Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
50.00Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
50.00Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
50.00Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
50.00Single6CM4Risperidone6CM4-D2-Risperidone
50.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
50.00Single6HLPNetupitant6HLP-NK1-Netupitant
50.00Single6TOTLemborexant6TOT-OX1-Lemborexant
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
50.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
50.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
50.00Single7SRQLSD7SRQ-5-HT2B-LSD
50.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
50.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
50.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
50.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
50.00Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GH1Epinephrine8GH1-β2-Epinephrine
50.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
50.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
50.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
50.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8X63Mepyramine8X63-H1-Mepyramine
50.00Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
50.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
50.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
50.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
50.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
50.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
50.00Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
50.00Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
50.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
50.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
50.00Consensushistamine_onOrthosteric Ligandh1_on h4_on
50.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
50.00Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
50.00Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
47.62Single3QAKUK-4320973QAK-A2A-UK-432097
47.62Single6HLOAprepitant6HLO-NK1-Aprepitant
47.62Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
47.37Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
47.37Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
47.37Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
47.37Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
47.37Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
47.37Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
47.37Single7EZCUKA7EZC-A2A-UKA
47.37Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
47.37Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
47.37Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.37Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
47.37Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.37Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
47.06Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
47.06Single5XPRBosentan5XPR-ETB-Bosentan
47.06Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
47.06Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
47.06Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
47.06Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
47.06Single6TP6Filorexant6TP6-OX1-Filorexant
47.06Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
47.06Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
47.06Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.06Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
47.06Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
47.06Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.06Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
47.06Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
47.06Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
47.06Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.06Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
47.06Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67Single5WS3EMPA5WS3-OX2-EMPA
46.67Single6AKXA4R6AKX-CCR5-A4R
46.67Single6B73PubChem 1319551386B73-κ-PubChem 131955138
46.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
46.67Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
46.67Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
46.67Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
46.67Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
46.67Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
46.67Single8IWESpermidine8IWE-TAAR9-Spermidine
46.67Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67Consensusorexin_offOrthosteric Ligandox2_off ox1_off
46.15Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
45.45Single5WF5UK-4320975WF5-A2A-UK-432097
45.00Single5WF6UK-4320975WF6-A2A-UK-432097
45.00Single6PT3DPI-2876PT3-δ-DPI-287
45.00Single7SK9CCX6627SK9-ACKR3-CCX662
45.00Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
45.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
45.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
44.44Single4DJHJDTic4DJH-κ-JDTic
44.44Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
44.44Single5V54Methiothepin5V54-5-HT1B-Methiothepin
44.44Single6E59L-7607356E59-NK1-L-760735
44.44Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
44.44Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
44.44Single7B6WCyclazosin7B6W-α1b-Cyclazosin
44.44Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
44.44Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
44.44Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
44.44Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
44.44Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
44.44Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
44.44Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
44.44Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.44Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
44.44Consensus5ht1_offOrthosteric Ligand5ht1b_off
44.44Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
44.44Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
44.44Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
44.44Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
44.44Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
44.44Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
44.44Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
44.44Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
43.75Single2YDOAdenosine2YDO-A2A-Adenosine
43.75Single3RZECidoxepin3RZE-H1-Cidoxepin
43.75Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
43.75Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
43.75Single4MBSMaraviroc4MBS-CCR5-Maraviroc
43.75Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
43.75Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
43.75Single6DS0Ly2660976DS0-5-HT2B-Ly266097
43.75Single6IQLL7458706IQL-D4-L745870
43.75Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
43.75Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
43.75Single6V9SGTPL114036V9S-OX1-GTPL11403
43.75Single6VI4JDTic6VI4-κ-JDTic
43.75Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
43.75Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
43.75Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
43.75Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
43.75Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
43.75Single8K5CAcipimox8K5C-HCA2-Acipimox
43.75Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
43.75Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
43.75Consensushca_onOrthosteric Ligandhca2_on hca3_on
43.75Consensushcar_onOrthosteric Ligandhca_on
43.75Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
43.48Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
43.48Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
42.86Single3UZAGTPL92363UZA-A2A-GTPL9236
42.86Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
42.86Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
42.86Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
42.86Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.86Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.86Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
42.86Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
42.86Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
42.86Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
42.31Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
42.11Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
42.11Single6A93Risperidone6A93-5-HT2A-Risperidone
42.11Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
42.11Single6ZG4HTL00099366ZG4-M1-HTL0009936
42.11Single7DFPSpiperone7DFP-D2-Spiperone
42.11Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
42.11Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.11Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
42.11Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
42.11Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
42.11Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
42.11Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
42.11Single8JWZAB9288JWZ-A2A-AB928-Na
42.11Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
42.11Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
42.11Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
42.11Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
42.11Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
41.67Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
41.18Single4DAJTiotropium4DAJ-M3-Tiotropium
41.18Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
41.18Single4MQSIperoxo4MQS-M2-Iperoxo
41.18Single4U14Tiotropium4U14-M3-Tiotropium
41.18Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
41.18Single5DSGTiotropium5DSG-M4-Tiotropium
41.18Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
41.18Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
41.18Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
41.18Single6DRXLisuride6DRX-5-HT2B-Lisuride
41.18Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
41.18Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
41.18Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
41.18Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
41.18Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
41.18Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
41.18Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
41.18Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
41.18Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
41.18Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
41.18Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
41.18Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
41.18Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
41.18Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
41.18Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
41.18Consensusadenosine_onOrthosteric Liganda1_on a2_on
41.18Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
41.18Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
41.18Consensusgi_hcarOrthosteric Ligandgi_hca
41.18Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
41.18Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
41.18Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
41.18Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
41.18Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
41.18Consensusnucleotide_onOrthosteric Ligandadenosine_on
41.18Consensustachykinin_offOrthosteric Ligandnk1_off
40.91Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
40.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
40.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
40.00Single6HLLCP999946HLL-NK1-CP99994
40.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
40.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
40.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
40.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
40.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
40.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
40.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
40.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
40.00Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
40.00Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
40.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
40.00Consensusorexin_onOrthosteric Ligandox2_on
39.13Single6PT2KGCHM076PT2-δ-KGCHM07
39.13Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
39.13Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
39.13Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
39.13Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
38.89Single5NM2ZM2413855NM2-A2A-ZM241385-Na
38.89Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
38.89Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
38.89Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
38.89Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
38.89Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
38.89Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
38.89Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
38.89Single7SINNPS-21437SIN-CaS-NPS-2143
38.89Single7SINNPS-21437SIN-CaS-NPS-2143
38.89Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
38.89Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
38.89Single8EA0Iperoxo8EA0-M3-Iperoxo
38.89Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
38.89Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
38.89Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
38.89Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
38.89Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
38.89Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
38.46Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
38.46Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
38.10Single5ZTYAM102575ZTY-CB2-AM10257
38.10Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.10Single7XN9L-054,5227XN9-SST2-L-054,522
38.10Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
38.10Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
38.10Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
38.10Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
38.10Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
38.10Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
38.10Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
38.10Consensuslpl_offOrthosteric Ligands1p_off lpa_off
38.10Consensuslpl_onOrthosteric Ligands1p_on lpa_on
38.10Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
37.50Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
37.50Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
37.50Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
37.50Single4S0VSuvorexant4S0V-OX2-Suvorexant
37.50Single5DHHSB-6121115DHH-NOP-SB-612111
37.50Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
37.50Single6AKYMaraviroc6AKY-CCR5-Maraviroc
37.50Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
37.50Single6ME2Ramelteon6ME2-MT1-Ramelteon
37.50Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
37.50Single6TPJSuvorexant6TPJ-OX2-Suvorexant
37.50Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
37.50Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
37.50Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
37.50Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
37.50Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
37.50Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
37.50Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
37.50Single7XRRLemborexant7XRR-OX2-Lemborexant
37.50Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
37.50Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
37.50Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
37.50Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
37.50Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
36.84Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
36.84Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
36.84Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
36.84Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
36.84Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
36.84Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
36.84Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
36.84Single7TUYGSK682753A7TUY-GPR183-GSK682753A
36.84Single7W41PD1762527W41-BB2-PD176252
36.84Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
36.84Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
36.84Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.84Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
36.84Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
36.84Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
36.84Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
36.84Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
36.84Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
36.84Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
36.84Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
36.84Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
36.84Consensusadenosine_offOrthosteric Liganda1_off a2_off
36.84Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
36.84Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
36.84Consensusbombesin_offOrthosteric Ligandbb2_off
36.84Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
36.84Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
36.84Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.84Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
36.84Consensuslpa_offOrthosteric Ligandlpa1_off
36.84Consensuslpa_onOrthosteric Ligandlpa1_on
36.84Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
36.84Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
36.36Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
36.36Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
36.36Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
36.36Consensussst_onOrthosteric Ligandsst2_on sst4_on
36.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
36.00Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
35.71Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
35.71Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
35.71Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
35.71Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
35.71Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
35.71Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
35.71Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
35.71Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
35.71Consensussensory_onOrthosteric Ligandopsin_on
35.29Single3REYPubChem 56973REY-A2A-PubChem 5697
35.29Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
35.29Single5IU4ZM2413855IU4-A2A-ZM241385-Na
35.29Single5IUBQ274563445IUB-A2A-Q27456344-Na
35.29Single5K2CZM2413855K2C-A2A-ZM241385-Na
35.29Single5NM4ZM2413855NM4-A2A-ZM241385-Na
35.29Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
35.29Single6AQFZM2413856AQF-A2A-ZM241385
35.29Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
35.29Single6TP3Nemorexant6TP3-OX1-Nemorexant
35.29Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
35.29Single7AROLUF58337ARO-A2A-LUF5833-Na
35.29Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
35.29Single7T32ZM2413857T32-A2A-ZM241385
35.29Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
35.29Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
35.29Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
35.29Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
35.29Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
35.29Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
35.29Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
35.29Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
35.29Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
35.29Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
35.29Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
35.29Consensuss1p_offOrthosteric Ligands1p1_off
35.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
35.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
35.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
35.00Single7K15MKD0467K15-BLT1-MKD046-Na
35.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
35.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
35.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
35.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
35.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
35.00Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Single8WU1KCA8WU1-CB1-KCA-Arrestin1
35.00Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
35.00Consensusblt_offOrthosteric Ligandblt1_off
35.00Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
35.00Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
35.00Consensusgs_steroidOrthosteric Ligandgs_bileacid
35.00Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
34.78Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
34.78Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
34.78Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
34.78Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
34.78Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
34.78Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
34.78Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
34.62Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.62Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.62Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
33.33Single4EIYZM2413854EIY-A2A-ZM241385-Na
33.33Single4YAYZD-71554YAY-AT1-ZD-7155
33.33Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
33.33Single5IU8Q274563475IU8-A2A-Q27456347-Na
33.33Single5OLGZM2413855OLG-A2A-ZM241385-Na
33.33Single5UENDU1725UEN-A1-DU172
33.33Single6GPSMK08126GPS-CCR2-MK0812
33.33Single6LPJZM2413856LPJ-A2A-ZM241385-Na
33.33Single6LPKZM2413856LPK-A2A-ZM241385-Na
33.33Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
33.33Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
33.33Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
33.33Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
33.33Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
33.33Single7PYRPSB-21157PYR-A2A-PSB-2115
33.33Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
33.33Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
33.33Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
33.33Single7WC5Psilocin7WC5-5-HT2A-Psilocin
33.33Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
33.33Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
33.33Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
33.33Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
33.33Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
33.33Single8CU6LJ-45178CU6-A2A-LJ-4517
33.33Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
33.33Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
33.33Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
33.33Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
33.33Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
33.33Single8K5DGSK2560738K5D-HCA2-GSK256073
33.33Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
33.33Consensusa2_offOrthosteric Liganda2a_off
33.33Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
33.33Consensusangiotensin_onOrthosteric Ligandat1_on
33.33Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
33.33Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
33.33Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
33.33Consensusblt_onOrthosteric Ligandblt1_on
33.33Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
33.33Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
33.33Consensusleuko_onOrthosteric Ligandblt_on
33.33Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
33.33Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
33.33Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
33.33Consensussteroid_onOrthosteric Ligandbileacid_on
32.14Single6IGLIRL16206IGL-ETB-IRL1620
32.14Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
32.14Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
32.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
32.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
32.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
31.82Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
31.82Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
31.82Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
31.58Single5IUAQ274563485IUA-A2A-Q27456348-Na
31.58Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
31.58Single6D26Fevipiprant6D26-DP2-Fevipiprant
31.58Single6GPXMK08126GPX-CCR2-MK0812
31.58Single6LPLZM2413856LPL-A2A-ZM241385-Na
31.58Single6LUQHaloperidol6LUQ-D2-Haloperidol
31.58Single6S0QZM2413856S0Q-A2A-ZM241385
31.58Single6WQAZM2413856WQA-A2A-ZM241385-Na
31.58Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
31.58Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
31.58Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
31.58Single7RM5ZM2413857RM5-A2A-ZM241385-Na
31.58Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
31.58Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
31.58Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
31.58Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
31.58Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
31.58Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
31.58Single8FYNZM2413858FYN-A2A-ZM241385-Na
31.58Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
31.58Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
31.58Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
31.58Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
31.58Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
31.58Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
31.25Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
31.25Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
31.25Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
31.25Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
31.25Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
31.25Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
31.25Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
31.25Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
31.25Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
31.25Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
31.25Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
31.25Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
31.25Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
31.25Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Single8K5BNiacin8K5B-HCA2-Niacin
31.25Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
31.25Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
31.03Single5GLHEndothelin-15GLH-ETB-Endothelin-1
31.03Single6IGKEndothelin-36IGK-ETB-Endothelin-3
30.77Single5MZPCaffeine5MZP-A2A-Caffeine-Na
30.77Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
30.77Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
30.77Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
30.77Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
30.77Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
30.77Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single7F8XNN90567F8X-CCKA-NN9056
30.43Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
30.43Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
30.43Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
30.43Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
30.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
30.00Single5XR8AM8415XR8-CB1-AM841
30.00Single5XRAAM115425XRA-CB1-AM11542
30.00Single7EPENAM5637EPE-mGlu-NAM563
30.00Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
30.00Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
30.00Single7PX4PSB-21137PX4-A2A-PSB-2113
30.00Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
30.00Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
30.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
30.00Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
30.00Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
30.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
30.00Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
30.00Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
30.00Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
30.00Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
29.63Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
29.63Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
29.63Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
29.41Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
29.41Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
29.41Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
29.41Single3PWHZM2413853PWH-A2A-ZM241385
29.41Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
29.41Single5K2DZM2413855K2D-A2A-ZM241385
29.41Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
29.41Single6JZHZM2413856JZH-A2A-ZM241385-Na
29.41Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
29.41Single6PS7ZM2413856PS7-A2A-ZM241385-Na
29.41Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
29.41Single7F8ULintitript7F8U-CCKA-Lintitript
29.41Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
29.41Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
29.41Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
29.41Single8GNGIstradefylline8GNG-A2A-Istradefylline
29.41Single8IHKAcifran8IHK-HCA3-Acifran
29.41Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
29.41Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
29.41Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
29.41Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
29.41Consensusgt_class-aOrthosteric Ligandgt_opsin
29.41Consensusgt_opsinOrthosteric Ligandgt_sensory
29.41Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
29.41Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
29.41Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
29.17Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
29.17Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
29.17Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
29.17Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
29.17Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
29.17Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
29.03Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
28.57Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
28.57Single4N4WSANT-14N4W-SMO-SANT-1
28.57Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
28.57Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
28.57Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
28.57Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
28.57Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
28.57Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
28.57Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
28.57Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
28.57Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
28.57Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
28.57Single8PWNTheophylline8PWN-A2A-Theophylline
28.57Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
28.57Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
28.57Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
28.57Consensusdp_offOrthosteric Liganddp2_off
28.57Consensusendothelin_onOrthosteric Ligandetb_on eta_on
28.57Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
28.57Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
28.57Consensusgi_class-fOther Ligandgi_frizzled
28.57Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
28.57Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
28.57Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
28.57Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
28.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
28.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
28.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
28.00Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
28.00Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
27.78Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
27.78Single5IU7Q274563465IU7-A2A-Q27456346-Na
27.78Single5JTBZM2413855JTB-A2A-ZM241385
27.78Single5K2BZM2413855K2B-A2A-ZM241385-Na
27.78Single5NLXZM2413855NLX-A2A-ZM241385-Na
27.78Single6TPKRetosiban6TPK-OT-Retosiban
27.78Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
27.78Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
27.78Single6ZG9GSK10347026ZG9-M1-GSK1034702
27.78Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
27.78Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
27.78Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
27.78Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
27.78Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
27.78Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
27.78Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
27.78Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
27.78Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
27.78Consensussensory_offOrthosteric Ligandopsin_off
27.78Consensusvasopressin-ot_offOrthosteric Ligandot_off
27.59Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
27.59Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
27.59Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.59Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
27.27Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
27.27Single6K1QIRL25006K1Q-ETB-IRL2500
27.27Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
27.27Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
27.27Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
27.27Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
27.27Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
27.27Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
27.27Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
27.27Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
27.27Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
26.92Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
26.92Single6JODAngiotensin II6JOD-AT2-Angiotensin II
26.92Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
26.92Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.92Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
26.92Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
26.67Single3RFMCaffeine3RFM-A2A-Caffeine
26.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
26.67Single8A2OTheophylline8A2O-A2A-Theophylline-Na
26.32Single3EMLZM2413853EML-A2A-ZM241385
26.32Single5K2AZM2413855K2A-A2A-ZM241385-Na
26.32Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
26.32Single5TGZAM65385TGZ-CB1-AM6538
26.32Single5VRAZM2413855VRA-A2A-ZM241385-Na
26.32Single6D27CAY104716D27-DP2-CAY10471
26.32Single6S0LZM2413856S0L-A2A-ZM241385
26.32Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
26.32Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
26.32Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
26.32Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
26.32Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
26.32Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
26.32Consensuscck_offOrthosteric Ligandccka_off
26.32Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
26.32Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
26.09Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
26.09Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
26.09Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
26.09Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
26.09Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
26.09Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
26.09Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
26.09Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
26.09Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
26.09Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
26.09Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
25.93Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.93Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
25.93Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
25.93Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.93Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
25.93Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
25.81Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
25.81Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
25.81Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
25.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
25.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
25.00Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
25.00Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
25.00Single5CGCHTL142425CGC-mGlu5-HTL14242
25.00Single5N2SPSB365N2S-A1-PSB36
25.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
25.00Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
25.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
25.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
25.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
25.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
25.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
25.00Single7C4SS1P7C4S-S1P3-S1P
25.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
25.00Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
25.00Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
25.00Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
25.00Single7QA8Peptide7QA8-STE2-Peptide
25.00Single7QA8Peptide7QA8-STE2-Peptide
25.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
25.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
25.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
25.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
25.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.00Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
25.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
25.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
25.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
25.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
25.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
25.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
25.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
25.00Single8QOTNanobody E8QOT-μ-Nanobody E
25.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
25.00Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
25.00Consensusclass-d_offOrthosteric Ligandste2_off
25.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
25.00Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
25.00Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
25.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
25.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
25.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
25.00Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
24.24Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
24.24Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
24.24Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
24.24Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
24.14Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
24.14Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
24.14Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
24.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
24.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
24.00Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
24.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
24.00Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
23.81Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
23.81Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
23.81Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
23.81Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
23.81Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
23.81Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
23.81Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
23.81Consensuscck_onOrthosteric Ligandccka_on cckb_on
23.81Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
23.81Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
23.81Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
23.81Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
23.81Consensusrelaxin_onOrthosteric Ligandrxfp4_on
23.53Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
23.53Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
23.53Single3OE9IT1t3OE9-CXCR4-IT1t
23.53Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
23.53Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
23.53Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
23.53Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
23.53Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
23.53Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
23.53Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
23.33Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
23.33Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
23.08Single3OE0CVX153OE0-CXCR4-CVX15
23.08Single6W25SHU91196W25-MC4-SHU9119-Ca
23.08Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
23.08Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
23.08Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
23.08Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single5X33BIIL2605X33-BLT1-BIIL260
22.73Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
22.73Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
22.73Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
22.73Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
22.73Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
22.73Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
22.73Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
22.73Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
22.73Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
22.73Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
22.73Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
22.58Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
22.22Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
22.22Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
22.22Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.22Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
22.22Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
22.22Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
22.22Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
22.22Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
22.22Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
22.22Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
22.22Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
22.22Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
22.22Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
22.22Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
22.22Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
22.22Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
22.22Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
22.22Consensusclass-d_onOrthosteric Ligandste2_on
22.22Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
22.22Consensusgi_class-dOrthosteric Ligandgi_ste
22.22Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.22Consensusmglu_onOther Ligandmglu2_on mglu4_on
21.74Single5CGDHTL142425CGD-mGlu5-HTL14242
21.74Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
21.74Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
21.74Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
21.74Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
21.74Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
21.74Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
21.74Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
21.74Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
21.74Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
21.43Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
21.43Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
21.43Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
21.43Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
21.43Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
21.43Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
21.05Single5UVIZM2413855UVI-A2A-ZM241385
21.05Single6MH8ZM2413856MH8-A2A-ZM241385
21.05Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
21.05Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
21.05Single7VODCariprazine7VOD-5-HT2A-Cariprazine
21.05Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
21.05Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single8K2WAMG4878K2W-CXCR3-AMG487
21.05Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
20.83Single5EE7MK08935EE7-Glucagon-MK0893
20.83Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
20.83Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
20.83Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusclass-d_offOrthosteric Ligandste2_off
20.83Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
20.83Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
20.69Single4XT3Fractalkine4XT3-US28-Fractalkine
20.69Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
20.69Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
20.69Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
20.69Consensusclass-d_onOrthosteric Ligandste2_on
20.69Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
20.59Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
20.51Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
20.00Single4XT1Fractalkine4XT1-US28-Fractalkine
20.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
20.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
20.00Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
20.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.00Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
20.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
20.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
20.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
20.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
20.00Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
20.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
20.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
20.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
20.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
20.00Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
20.00Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
20.00Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
20.00Consensusgi_class-dOrthosteric Ligandgi_ste
20.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
20.00Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.00Consensusgo_class-b1Orthosteric Ligandgo_crf
20.00Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.00Consensushcar_offOrthosteric Ligandsuccinate_off
20.00Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
20.00Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
20.00Consensuspth_onOrthosteric Ligandpth1_on pth2_on
20.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
20.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
19.35Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
19.35Single8IY6Endothelin-18IY6-ETB-Endothelin-1
19.35Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
19.35Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
19.23Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
19.23Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
19.23Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
19.23Consensussst_offOrthosteric Ligandsst2_off
19.05Single4NTJAZD12834NTJ-P2Y12-AZD1283
19.05Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
19.05Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
19.05Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
19.05Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
19.05Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
19.05Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
19.05Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
19.05Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
19.05Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
19.05Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
19.05Consensusep_offOrthosteric Ligandep4_off
19.05Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.92Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
18.92Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
18.75Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
18.75Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
18.75Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
18.75Single6TQ9SB-4081246TQ9-OX1-SB-408124
18.75Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
18.75Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
18.52Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
18.52Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
18.52Single7XNACYN1548067XNA-SST2-CYN154806
18.52Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
18.52Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
18.52Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
18.52Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
18.52Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
18.18Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
18.18Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
18.18Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
18.18Single7P2L4YI7P2L-mGlu5-4YI
18.18Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
18.18Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
18.18Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
18.18Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
18.18Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
18.18Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
18.18Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
18.18Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
18.18Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
18.18Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
18.18Consensuschemerin_onOrthosteric Ligandcml1_on
18.18Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
18.18Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
17.86Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.86Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.86Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
17.86Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
17.86Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
17.86Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.65Single3OE6IT1t3OE6-CXCR4-IT1t
17.65Single3OE8IT1t3OE8-CXCR4-IT1t
17.65Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
17.65Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.65Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
17.65Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
17.39Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
17.39Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
17.39Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
17.39Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
17.39Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
17.39Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
17.39Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
17.39Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
17.39Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
17.39Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
17.39Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
17.39Consensusclass-b2_onOrthosteric Ligandadgrg_on
17.39Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
17.39Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
17.24Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
17.24Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
17.24Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
17.24Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
17.24Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.14Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
17.14Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
16.67Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
16.67Single5L7IVismodegib5L7I-SMO-Vismodegib
16.67Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
16.67Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
16.67Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.67Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
16.67Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
16.67Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
16.67Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
16.67Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
16.67Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
16.67Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
16.67Consensusclass-t_onOrthosteric Ligandtaste2_on
16.67Consensusgs_class-tOrthosteric Ligandgs_taste
16.67Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
16.67Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
16.13Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
16.13Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
16.13Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
16.13Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.13Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
16.00Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
16.00Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Single3ODUIT1t3ODU-CXCR4-IT1t
15.79Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
15.79Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
15.79Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.79Single7F8YDevazepide7F8Y-CCKA-Devazepide
15.79Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
15.79Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
15.79Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
15.79Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.62Single6LMLGlucagon6LML-Glucagon-Glucagon
15.62Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.62Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
15.62Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
15.62Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
15.62Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
15.62Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
15.62Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
15.38Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
15.38Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
15.38Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
15.38Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
15.38Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
15.15Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
15.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
15.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
15.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
15.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
15.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
15.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
15.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
15.00Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
15.00Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
15.00Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
15.00Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
15.00Consensusgnrh_offOrthosteric Ligandgnrh1_off
14.81Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
14.81Single7SK5CXCL127SK5-ACKR3-CXCL12
14.81Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
14.81Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.71Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
14.71Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
14.71Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
14.71Consensusglp_onOrthosteric Ligandglp1_on glp2_on
14.63Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
14.29Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
14.29Single6FFHFenobam6FFH-mGlu5-Fenobam
14.29Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
14.29Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
14.29Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
14.29Single6IIVDaltroban6IIV-TP-Daltroban
14.29Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
14.29Single7F83PF-051904577F83-Ghrelin-PF-05190457
14.29Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
14.29Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
14.29Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
14.29Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
14.29Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
14.29Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
14.29Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
14.29Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
14.29Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
14.29Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
13.89Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
13.89Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
13.79Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
13.79Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
13.79Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
13.79Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
13.64Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
13.64Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
13.64Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.64Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
13.64Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
13.64Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
13.64Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
13.64Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
13.64Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
13.51Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
13.51Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
13.33Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
13.33Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
13.33Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
13.33Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
13.33Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
13.04Single5TZR-5TZR-FFA1 (GPR40)-MK8666
13.04Single5V56TC1145V56-SMO-TC114
13.04Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
13.04Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
13.04Single7F1TMIP-1a7F1T-CCR5-MIP-1a
13.04Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
13.04Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
13.04Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
13.04Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
12.90Single6FJ3PTH6FJ3-PTH1-PTH
12.90Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
12.90Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
12.90Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
12.90Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
12.90Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Single7SK3CXCL127SK3-ACKR3-CXCL12
12.90Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
12.90Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
12.50Single4PY02MeSATP4PY0-P2Y12-2MeSATP
12.50Single4XEENeurotensin4XEE-NTS1-Neurotensin
12.50Single4XESNeurotensin4XES-NTS1-Neurotensin
12.50Single6IIURamatroban6IIU-TP-Ramatroban
12.50Single6OS2TRV0266OS2-AT1-TRV026
12.50Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
12.50Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
12.50Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
12.50Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
12.50Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
12.50Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
12.50Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
12.50Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
12.50Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
12.50Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
12.50Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
12.50Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
12.50Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
12.50Consensusclass-c_onOther Ligandgabab_on mglu_on
12.50Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
12.50Consensusnts_offOrthosteric Ligandnts1_off
12.20Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
12.12Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
12.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
12.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
12.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
12.00Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
12.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
12.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
12.00Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
12.00Consensuscyslt_offOrthosteric Ligandcyslt2_off
12.00Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
11.54Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
11.54Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.54Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
11.54Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
11.54Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
11.54Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
11.54Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Consensusgs_class-b2Orthosteric Ligandgs_adgr
11.54Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
11.11Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
11.11Single6LI0GTPL98046LI0-GPR52-GTPL9804
11.11Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
11.11Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
11.11Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
11.11Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
11.11Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
11.11Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
11.11Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
10.81Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
10.71Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
10.71Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
10.71Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
10.71Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.53Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
10.53Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
10.53Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.53Consensusgo_class-b2Orthosteric Ligandgo_adhesion
10.00Single5U09Taranabant5U09-CB1-Taranabant
10.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
10.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
10.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
10.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
10.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
10.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
10.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
10.00Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
10.00Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
10.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
10.00Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
10.00Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
9.76Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
9.68Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
9.68Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
9.52Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
9.52Single6ZINSR486926ZIN-NTS1-SR48692
9.52Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
9.52Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
9.52Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
9.52Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
9.52Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
9.38Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
9.38Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
9.38Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
9.38Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
9.09Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.09Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.09Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
9.09Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
9.09Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
8.82Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
8.82Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
8.82Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
8.82Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
8.70Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
8.70Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.70Single6Z4SSR486926Z4S-NTS1-SR48692
8.70Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
8.70Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.70Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
8.57Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
8.57Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
8.57Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
8.33Single4BV0Neurotensin4BV0-NTS1-Neurotensin
8.33Single5V57TC1145V57-SMO-TC114
8.33Single6OS1TRV0266OS1-AT1-TRV026
8.33Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.33Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.33Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
8.33Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
8.33Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.11Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
8.00Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
8.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
8.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
8.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.00Consensuschemokine_offOrthosteric Ligandcxcr_off
8.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
8.00Consensuscxcr_offOrthosteric Ligandcxcr4_off
8.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
7.89Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
7.69Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
7.69Consensusclass-c_offOther Ligandgabab_off mglu_off
7.69Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
7.69Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.50Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.41Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
7.14Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
6.90Single7SHEPI; PE7SHE-GPR158-PI; PE
6.90Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.45Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
6.25Single6W25Ca6W25-MC4-SHU9119-Ca
5.88Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
5.88Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
5.88Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.88Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
5.71Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
5.56Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
5.56Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.56Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
5.56Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
5.26Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.26Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
5.26Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
5.26Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
5.26Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
5.26Consensush3_on_alloOther Ligand7F61-H3-PF-03654746-Cholesterol
5.26Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
5.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
5.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
5.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
5.00Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
5.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
5.00Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.00Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.76Single4QINSAG1.54QIN-SMO-SAG1.5
4.76Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.76Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
4.76Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
4.76Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
4.76Consensusclass-f_offOrthosteric Ligandsmo_off
4.76Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
4.76Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.55Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.55Single7VV6C48/807VV6-MRGPRX2-C48/80
4.55Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
4.55Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.55Single8IYXYL-3658IYX-GPR34-YL-365
4.55Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.55Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.55Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
4.55Consensusgi_class-fOrthosteric Ligandgi_frizzled
4.55Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.55Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
4.35Single5T04Neurotensin5T04-NTS1-Neurotensin
4.35Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
4.35Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
4.35Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
4.35Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
4.35Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
4.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
4.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.85Single7SHEPI; PE7SHE-GPR158-PI; PE
3.85Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
3.85Consensusnts_onOrthosteric Ligandnts1_on
3.70Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
3.70Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
3.70Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
3.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.57Single6KNMJN241-96KNM-Apelin-JN241-9
3.45Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
3.45Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
3.33Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.78Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.70Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.70Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.70Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.63Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.56Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.56Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.50Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.50Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.38Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.27Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.22Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.22Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.13Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F133 R:R:V129 5.24 2 Yes No 5 6 1 1
R:R:V129 W:W:?1 5.37 2 No Yes 6 0 1 0
R:R:D130 R:R:Y141 11.49 0 No Yes 8 7 2 1
R:R:F133 R:R:Y132 6.19 2 Yes Yes 5 8 1 2
R:R:F133 R:R:Y141 11.35 2 Yes Yes 5 7 1 1
R:R:F133 W:W:?1 16.46 2 Yes Yes 5 0 1 0
R:R:S137 W:W:?1 5.41 0 No Yes 6 0 1 0
R:R:K140 R:R:L144 4.23 2 No No 5 4 1 1
R:R:K140 W:W:?1 11.43 2 No Yes 5 0 1 0
R:R:L145 R:R:Y141 8.21 2 No Yes 7 7 1 1
R:R:Y141 W:W:?1 6.34 2 Yes Yes 7 0 1 0
R:R:L144 W:W:?1 23.69 2 No Yes 4 0 1 0
R:R:L145 W:W:?1 4.99 2 No Yes 7 0 1 0
R:R:K149 W:W:?1 16.52 0 No Yes 5 0 1 0
R:R:I153 W:W:?1 11.57 0 No Yes 6 0 1 0
R:R:M156 W:W:?1 3.82 0 No Yes 4 0 1 0
R:R:V129 R:R:V218 3.21 2 No No 6 6 1 2
R:R:K149 R:R:T146 3 0 No No 5 8 1 2
R:R:P138 R:R:S137 1.78 0 No No 8 6 2 1
R:R:I153 R:R:V152 1.54 0 No No 6 4 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
58.33Single7LJCMevidalen7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
58.33Consensusd1_on_alloOther Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
50.00Single7LJDMevidalen7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
50.00Single7X2FMevidalen7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
38.46Single7CKZMevidalen7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
33.33Single5KW2PubChem 1330539535KW2-FFA1 (GPR40)-PubChem 133053953
21.74Single7SHEPI; PE7SHE-GPR158-PI; PE
21.74Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
20.00Single7SHEPI; PE7SHE-GPR158-PI; PE
19.05Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
18.75Single8G2YLPC8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2
17.65Single7WU3K6G7WU3-ADGRF1-K6G-Gs/&β;1/&γ;2
15.79Single7WU5K6G7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2
15.00Single7WU4K6G7WU4-ADGRF1-K6G-Gi1/&β;1/&γ;2
13.64Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
11.11Single5O9HNDT95137275O9H-C5a1-NDT9513727
10.53Single6C1RAvacopan; Na6C1R-C5a1-PMX53-Avacopan; Na
10.53Consensusadgrf1_on_alloOther Ligand7WU5-ADGRF1-K6G-Gi1/&β;1/&γ;2 8G2Y-ADGRF1-LPC-chim(Gs-CtGq)/&β;1/&γ;2
10.53Consensusc5a1_off_ortoalloOther Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
7.69Single4PXFOctyl Beta-D-Glucopyranoside4PXF-Rhodopsin-Octyl Beta-D-Glucopyranoside-Arrestin1_Finger_loop
7.14Single5XSZGlyceryl Mono-oleate5XSZ-LPA6-Glyceryl Mono-oleate
6.25Single6OBAGTPL110746OBA-β2-(S)-Alprenolol-GTPL11074
6.25Single8WG8Peptide8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Consensusbeta2_off_alloOther Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
5.56Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
5.26Single8IYXYL-3658IYX-GPR34-YL-365

PDB Summary
PDB 6N48
Class A
SubFamily Amine
Type Adrenergic
SubType Beta2
Species Homo sapiens
Ligand BI167107
Other Ligand(s) PubChem 138454256
Protein Partners -
PDB Resolution 3.2
Date 2019-06-26
D.O.I. 10.1126/science.aaw8981
Net Summary
Imin 3.53
Number of Linked Nodes 260
Number of Links 292
Number of Hubs 38
Number of Links mediated by Hubs 156
Number of Communities 6
Number of Nodes involved in Communities 53
Number of Links involved in Communities 76
Path Summary
Number Of Nodes in MetaPath 113
Number Of Links MetaPath 112
Number of Shortest Paths 56160
Length Of Smallest Path 3
Average Path Length 12.179
Length of Longest Path 26
Minimum Path Strength 1.35
Average Path Strength 7.42857
Maximum Path Strength 23.735
Minimum Path Correlation 0.7
Average Path Correlation 0.924256
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.7619
Average % Of Corr. Nodes 52.9149
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.2568
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeP0G
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeP0G
Name8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one
Synonyms
Identifier5-hydroxy-8-[(1R)-1-hydroxy-2-[[2-methyl-1-(2-methylphenyl)propan-2-yl]amino]ethyl]-4H-1,4-benzoxazin-3-one
FormulaC21 H26 N2 O4
Molecular Weight370.442
SMILESCc1ccccc1CC(C)(C)NC[C@@H](c2ccc(c3c2OCC(=O)N3)O)O
PubChem49837874
Formal Charge0
Total Atoms53
Total Chiral Atoms1
Total Bonds55
Total Aromatic Bonds12

CodeKBY
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeKBY
NameN-[(3R)-4-(4-tert-butylphenyl)-3-({2-[(4-methoxyphenyl)sulfanyl]-5-[methyl(propan-2-yl)sulfamoyl]benzene-1-carbonyl}amino)butanoyl]glycine
Synonyms
Identifier2-[[(3~{R})-4-(4-~{tert}-butylphenyl)-3-[[2-(4-methoxyphenyl)sulfanyl-5-[methyl(propan-2-yl)sulfamoyl]phenyl]carbonylamino]butanoyl]amino]ethanoic acid
FormulaC34 H43 N3 O7 S2
Molecular Weight669.851
SMILESCC(C)N(C)S(=O)(=O)c1ccc(c(c1)C(=O)N[C@H](Cc2ccc(cc2)C(C)(C)C)CC(=O)NCC(=O)O)Sc3ccc(cc3)OC
PubChem138454256
Formal Charge0
Total Atoms89
Total Chiral Atoms1
Total Bonds91
Total Aromatic Bonds18

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP07550
Sequence
>6N48_Chain_R
DEVWVVGMG IVMSLIVLA IVFGNVLVI TAIAKFERL QTVTNYFIT 
SLACADLVM GLAVVPFGA AHILTKTWT FGNFWCEFW TSIDVLCVT 
ASIETLCVI AVDRYFAIT SPFKYQSLL TKNKARVII LMVWIVSGL 
TSFLPIQMH WYRATHQEA INCYAEETC CDFFTNQAY AIASSIVSF 
YVPLVIMVF VYSRVFQEA KRQLQKFAL KEHKALKTL GIIMGTFTL 
CWLPFFIVN IVHVIQDNL IRKEVYILL NWIGYVNSG FNPLIYCRS 
PDFRIAFQE LLCL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2R4RAAmineAdrenergicβ2Homo sapiens---3.42007-11-0610.1038/nature06325
2R4SAAmineAdrenergicβ2Homo sapiens---3.42007-11-0610.1038/nature06325
2RH1AAmineAdrenergicβ2Homo sapiens(S)-Carazolol--2.42007-10-3010.1126/science.1150577
3D4SAAmineAdrenergicβ2Homo sapiensTimolol Maleate--2.82008-06-1710.1016/j.str.2008.05.001
3KJ6AAmineAdrenergicβ2Homo sapiens---3.42010-02-1610.1038/nature08650
3NY8AAmineAdrenergicβ2Homo sapiensICI 118-551--2.842010-08-1110.1021/ja105108q
3NY9AAmineAdrenergicβ2Homo sapiensPubChem 913103--2.842010-08-1110.1021/ja105108q
3NYAAAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--3.162010-08-1110.1021/ja105108q
3P0GAAmineAdrenergicβ2Homo sapiensBI167107--3.52011-01-1910.1038/nature09648
3PDSAAmineAdrenergicβ2Homo sapiensHydroxybenzylisoproterenol--3.52011-01-1210.1038/nature09665
3SN6AAmineAdrenergicβ2Homo sapiensBI167107-Gs/&β;1/&γ;23.22011-07-2010.1038/nature10361
4GBRAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.992012-10-2410.1371/journal.pone.0046039
4LDEAAmineAdrenergicβ2Homo sapiensBI167107--2.792013-09-2510.1038/nature12572
4LDLAAmineAdrenergicβ2Homo sapiensHydroxybenzylisoproterenol--3.12013-09-2510.1038/nature12572
4LDOAAmineAdrenergicβ2Homo sapiensL-Epinephrine--3.22013-09-2510.1038/nature12572
4QKXAAmineAdrenergicβ2Homo sapiensPubChem 76210628--3.32014-07-2310.1073/pnas.1410415111
5D5AAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--2.482016-01-1310.1107/S2059798315021683
5D5BAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.82016-01-1310.1107/S2059798315021683
5D6LAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.22016-08-1710.1038/nprot.2017.057
5JQHAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.22016-07-1310.1038/nature18636
5X7DAAmineAdrenergicβ2Homo sapiens(S)-CarazololPubChem 129318963-2.72017-08-1610.1038/nature23652
6E67AAmineAdrenergicβ2Homo sapiensBI167107-Gs (fused)3.72019-06-0510.1016/j.cell.2019.04.021
6MXTAAmineAdrenergicβ2Homo sapiensSalmeterol--2.962018-11-1410.1038/s41589-018-0145-x
6NI3AAmineAdrenergicβ2Homo sapiensBI167107-Gs/&β;1/&γ;23.82019-11-2010.1038/s41594-019-0330-y
6OBAAAmineAdrenergicβ2Homo sapiens(S)-AlprenololGTPL11074-3.12020-03-2510.1038/s41589-020-0549-2
6PRZAAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--2.82019-11-1310.1107/S2052252519013137
6PS0AAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.42019-11-1310.1107/S2052252519013137
6PS1AAmineAdrenergicβ2Homo sapiensTimolol--3.22019-11-1310.1107/S2052252519013137
6PS2AAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--2.42019-11-1310.1107/S2052252519013137
6PS3AAmineAdrenergicβ2Homo sapiens(S)-Carvedilol--2.52019-11-1310.1107/S2052252519013137
6PS4AAmineAdrenergicβ2Homo sapiensICI 118-551--2.62019-11-1310.1107/S2052252519013137
6PS5AAmineAdrenergicβ2Homo sapiens(S)-Propranolol--2.92019-11-1310.1107/S2052252519013137
6PS6AAmineAdrenergicβ2Homo sapiensTimolol--2.72019-11-1310.1107/S2052252519013137
7BZ2AAmineAdrenergicβ2Homo sapiensArformoterol-Gs/&β;1/&γ;23.822020-08-0510.1038/s41421-020-0176-9
7DHIAAmineAdrenergicβ2Homo sapiensSalbutamol-Gs/&β;1/&γ;23.262020-12-1610.1093/nsr/nwaa284
7DHRAAmineAdrenergicβ2Homo sapiensIsoprenaline-Gs/&β;1/&γ;23.82020-12-1610.1093/nsr/nwaa284
7XKAAAmineAdrenergicβ2Homo sapiensEpinephrine--3.12023-04-2610.1038/s41467-023-37808-y
8GDZAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GE1AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE3AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GE4AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GE6AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE7AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE8AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE9AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEAAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEBAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8GECAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEDAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEEAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.72024-03-0610.1038/s41586-024-07153-1
8GEFAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8GEGAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8GEHAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;242024-03-0610.1038/s41586-024-07153-1
8GEIAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;24.12024-03-0610.1038/s41586-024-07153-1
8GEJAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;24.22024-03-0610.1038/s41586-024-07153-1
8GFVAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.12024-03-0610.1038/s41586-024-07153-1
8GFWAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFXAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFYAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFZAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG0AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;22.92024-03-0610.1038/s41586-024-07153-1
8GG1AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG2AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG3AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.12024-03-0610.1038/s41586-024-07153-1
8GG4AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.22024-03-0610.1038/s41586-024-07153-1
8GG5AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.22024-03-0610.1038/s41586-024-07153-1
8GG6AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG7AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG8AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG9AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GGAAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGBAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGCAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GGEAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGFAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8GGIAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGJAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGKAAmineAdrenergicβ2Homo sapiensEpinephrine--3.32024-03-0610.1038/s41586-024-07153-1
8GGLAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGMAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGNAAmineAdrenergicβ2Homo sapiensEpinephrine--3.32024-03-0610.1038/s41586-024-07153-1
8GGOAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGPAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGQAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGRAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGSAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGTAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGUAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGVAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGWAAmineAdrenergicβ2Homo sapiensEpinephrine--3.62024-03-0610.1038/s41586-024-07153-1
8GGXAAmineAdrenergicβ2Homo sapiensEpinephrine--3.62024-03-0610.1038/s41586-024-07153-1
8GGYAAmineAdrenergicβ2Homo sapiensEpinephrine--3.92024-03-0610.1038/s41586-024-07153-1
8GGZAAmineAdrenergicβ2Homo sapiensEpinephrine--3.92024-03-0610.1038/s41586-024-07153-1
8GH0AAmineAdrenergicβ2Homo sapiensEpinephrine--42024-03-0610.1038/s41586-024-07153-1
8GH1AAmineAdrenergicβ2Homo sapiensEpinephrine--4.12024-03-0610.1038/s41586-024-07153-1
8JJ8AAmineAdrenergicβ2Homo sapiensFormoterol--3.22023-09-0610.1038/s41589-023-01389-0
8JJLAAmineAdrenergicβ2Homo sapiensOlodaterol--3.22023-09-0610.1038/s41589-023-01389-0
8JJOAAmineAdrenergicβ2Homo sapiensAlprenolol--3.42023-09-0610.1038/s41589-023-01389-0
8UNLAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNMAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNNAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNOAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNPAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNQAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNRAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNSAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNTAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNUAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UNVAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNWAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNXAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UNYAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UNZAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8UO0AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UO1AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UO2AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UO3AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UO4AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;242024-03-0610.1038/s41586-024-07153-1




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6N48.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.