Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:I47 3.08571718
2R:R:L64 4.004538
3R:R:N69 5.44439
4R:R:F71 4.9748
5R:R:L75 3.6425409
6R:R:D79 7.295419
7R:R:M82 6.3625417
8R:R:T118 5.57406
9R:R:D130 5.885448
10R:R:R131 8.578529
11R:R:Y132 5.76408
12R:R:Y141 8.028527
13R:R:L230 7.0975425
14R:R:E237 4.155403
15R:R:F264 7.38524
16R:R:H269 5.996525
17R:R:F282 9.0675419
18R:R:W286 10.296518
19R:R:F290 13.39407
20R:R:Y316 5.065416
21R:R:N318 6.845419
22R:R:S319 6.0225419
23R:R:Y326 9.975439
24R:R:P330 5.89435
25R:R:F332 8.25539
26R:R:F336 5.17407
27R:R:L339 4.338556
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:G320 R:R:I47 11.66471.76NoYes078
2R:R:I43 R:R:I47 11.51731.47NoYes068
3R:R:G83 R:R:I47 13.54173.53NoYes078
4R:R:G83 R:R:V87 11.66473.68NoNo077
5R:R:D79 R:R:I47 14.6034.2YesYes198
6R:R:I47 R:R:S319 23.87976.19YesYes189
7R:R:I55 R:R:T56 10.98661.52NoNo075
8R:R:L339 R:R:T56 15.99842.95YesNo065
9R:R:F336 R:R:L53 10.34794.87YesNo076
10R:R:F332 R:R:F336 28.586911.79YesYes097
11R:R:F332 R:R:P330 57.43912.89YesYes395
12R:R:P330 R:R:S329 61.4785.34YesNo358
13R:R:K273 R:R:S329 67.3844.59NoNo078
14R:R:K270 R:R:K273 68.5247.18NoNo077
15R:R:H269 R:R:K270 69.64432.62YesNo057
16R:R:F264 R:R:H269 71.94385.66YesYes245
17R:R:F264 R:R:Y141 79.3739.28YesYes247
18R:R:R131 R:R:Y141 84.895811.32YesYes297
19R:R:L275 R:R:R131 87.06768.5NoYes289
20R:R:I278 R:R:L275 89.15092.85NoNo088
21R:R:I278 R:R:N322 91.18515.66NoNo089
22R:R:D79 R:R:N322 91.81412.69YesNo099
23R:R:A76 R:R:T73 12.11671.68NoNo096
24R:R:A76 R:R:V54 13.83653.39NoNo099
25R:R:F336 R:R:V54 15.61522.62YesNo079
26R:R:F61 R:R:L64 15.31054.87NoYes068
27R:R:F332 R:R:L64 26.3076.09YesYes398
28R:R:F71 R:R:I154 24.61676.28YesNo088
29R:R:I154 R:R:S74 26.23823.1NoNo089
30R:R:L75 R:R:S74 35.44613YesNo099
31R:R:L75 R:R:S120 65.95913YesNo099
32R:R:F282 R:R:S120 66.75519.25YesNo099
33R:R:F282 R:R:N318 81.18128.46YesYes199
34R:R:N318 R:R:S319 1004.47YesYes199
35R:R:F71 R:R:I153 10.84916.28YesNo086
36R:R:L75 R:R:T123 21.35424.42YesNo098
37R:R:L124 R:R:L75 26.16944.15NoYes089
38R:R:C116 R:R:M82 12.43124.86NoYes077
39R:R:M82 R:R:S319 21.79644.6YesYes179
40R:R:T123 R:R:V157 19.67374.76NoNo087
41R:R:A119 R:R:V157 18.07191.7NoNo077
42R:R:A119 R:R:S161 16.35223.42NoNo078
43R:R:S161 R:R:T118 11.07514.8NoYes086
44R:R:N318 R:R:W286 17.885211.3YesYes198
45R:R:F282 R:R:I121 32.39987.54YesNo097
46R:R:I121 R:R:L212 26.62155.71NoNo077
47R:R:L124 R:R:M215 24.73475.65NoNo088
48R:R:M215 R:R:V216 21.023.04NoNo085
49R:R:L212 R:R:V216 21.90452.98NoNo075
50R:R:F133 R:R:V129 15.51692.62NoNo056
51R:R:F133 R:R:Y132 18.56332.06NoYes058
52R:R:V222 R:R:Y132 27.58453.79NoYes088
53R:R:V222 R:R:Y219 30.55232.52NoNo089
54R:R:M279 R:R:Y219 33.392317.96NoNo789
55R:R:M215 R:R:M279 39.33774.33NoNo088
56R:R:F290 R:R:W286 25.98273.01YesYes078
57R:R:F208 R:R:F290 21.275636.44NoYes087
58R:R:F208 R:R:L287 11.91042.44NoNo086
59R:R:D79 R:R:S319 78.24298.83YesYes199
60R:R:F282 R:R:W286 12.971711.02YesYes198
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 3KJ6
Class A
SubFamily Amine
Type Adrenergic
SubType Beta2
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.4
Date 2010-02-16
D.O.I. doi.org/10.1038/nature08650
Net Summary
Imin 2.62
Number of Linked Nodes 206
Number of Links 221
Number of Hubs 27
Number of Links mediated by Hubs 99
Number of Communities 7
Number of Nodes involved in Communities 41
Number of Links involved in Communities 52
Path Summary
Number Of Nodes in MetaPath 61
Number Of Links MetaPath 60
Number of Shortest Paths 19464
Length Of Smallest Path 3
Average Path Length 14.8677
Length of Longest Path 35
Minimum Path Strength 1.285
Average Path Strength 5.70185
Maximum Path Strength 21.97
Minimum Path Correlation 0.7
Average Path Correlation 0.932541
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.84615
Average % Of Corr. Nodes 47.5343
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.1194
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP07550
Sequence
>3KJ6_Chain_R
GMGIVMSLI VLAIVFGNV LVITAIAFE RLQTVTNYF ITSLACADL 
VMGLAVVPF GAFWTSIDV LCVTASIET LCVIAVDRY FAITSPFKY 
QSLLTKNKA RVIILMVWI VSGLTSSIV SFYVPLVIM VFVYSRVFQ 
EAKRQLQKI DKSEGRFHV KFCLKEHKA LKTLGIIMG TFTLCWLPF 
FIVYILLNW IGYVNSGFN PLIYCRSPD FRIAFQELL CLRRSS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2RH1AAmineAdrenergicβ2Homo sapiensCarazolol--2.42007-10-30doi.org/10.1126/science.1150577
2R4RAAmineAdrenergicβ2Homo sapiens---3.42007-11-06doi.org/10.1038/nature06325
2R4SAAmineAdrenergicβ2Homo sapiens---3.42007-11-06doi.org/10.1038/nature06325
3D4SAAmineAdrenergicβ2Homo sapiensTimolol--2.82008-06-17doi.org/10.1016/j.str.2008.05.001
3NY8AAmineAdrenergicβ2Homo sapiensICI118-551--2.842010-08-11doi.org/10.1021/ja105108q
3NY9AAmineAdrenergicβ2Homo sapiensPubChem 913103--2.842010-08-11doi.org/10.1021/ja105108q
3NYAAAmineAdrenergicβ2Homo sapiensAlprenolol--3.162010-08-11doi.org/10.1021/ja105108q
3PDSAAmineAdrenergicβ2Homo sapiensFAUC50--3.52011-01-12doi.org/10.1038/nature09665
3P0GAAmineAdrenergicβ2Homo sapiensBI167107--3.52011-01-19doi.org/10.1038/nature09648
3SN6AAmineAdrenergicβ2Homo sapiensBI167107-Gs/β1/γ23.22011-07-20doi.org/10.1038/nature10361
3SN6 (No Gprot) AAmineAdrenergicβ2Homo sapiensBI167107-3.22011-07-20doi.org/10.1038/nature10361
4GBRAAmineAdrenergicβ2Homo sapiensCarazolol--3.992012-10-24doi.org/10.1371/journal.pone.0046039
4LDEAAmineAdrenergicβ2Homo sapiensBI167107--2.792013-09-25doi.org/10.1038/nature12572
4LDLAAmineAdrenergicβ2Homo sapiensHydroxybenzyl Isoproterenol--3.12013-09-25doi.org/10.1038/nature12572
4LDOAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22013-09-25doi.org/10.1038/nature12572
4QKXAAmineAdrenergicβ2Homo sapiensPubChem 76210628--3.32014-07-23doi.org/10.1073/pnas.1410415111
5D5AAAmineAdrenergicβ2Homo sapiensCarazolol--2.482016-01-13doi.org/10.1107/S2059798315021683
5D5BAAmineAdrenergicβ2Homo sapiensCarazolol--3.82016-01-13doi.org/10.1107/S2059798315021683
5JQHAAmineAdrenergicβ2Homo sapiensCarazolol--3.22016-07-13doi.org/10.1038/nature18636
5D6LAAmineAdrenergicβ2Homo sapiensCarazolol--3.22016-08-17doi.org/10.1038/nprot.2017.057
5X7DAAmineAdrenergicβ2Homo sapiensCarazololPubChem 129318963-2.72017-08-16doi.org/10.1038/nature23652
6MXTAAmineAdrenergicβ2Homo sapiensSalmeterol--2.962018-11-14doi.org/10.1038/s41589-018-0145-x
6E67AAmineAdrenergicβ2Homo sapiensBI167107-Gs(CT)3.72019-06-05doi.org/10.1016/j.cell.2019.04.021
6E67 (No Gprot) AAmineAdrenergicβ2Homo sapiensBI167107-3.72019-06-05doi.org/10.1016/j.cell.2019.04.021
6N48AAmineAdrenergicβ2Homo sapiensBI167107PubChem 138454256-3.22019-06-26doi.org/10.1126/science.aaw8981
6PRZAAmineAdrenergicβ2Homo sapiensAlprenolol--2.82019-11-13doi.org/10.1107/S2052252519013137
6PS0AAmineAdrenergicβ2Homo sapiensCarazolol--3.42019-11-13doi.org/10.1107/S2052252519013137
6PS1AAmineAdrenergicβ2Homo sapiensTimolol--3.22019-11-13doi.org/10.1107/S2052252519013137
6PS2AAmineAdrenergicβ2Homo sapiensAlprenolol--2.42019-11-13doi.org/10.1107/S2052252519013137
6PS3AAmineAdrenergicβ2Homo sapiensCarvedilol--2.52019-11-13doi.org/10.1107/S2052252519013137
6PS4AAmineAdrenergicβ2Homo sapiensICI118-551--2.62019-11-13doi.org/10.1107/S2052252519013137
6PS5AAmineAdrenergicβ2Homo sapiensPropranolol--2.92019-11-13doi.org/10.1107/S2052252519013137
6PS6AAmineAdrenergicβ2Homo sapiensTimolol--2.72019-11-13doi.org/10.1107/S2052252519013137
6NI3AAmineAdrenergicβ2Homo sapiensBI167107-Gs/β1/γ23.82019-11-20doi.org/10.1038/s41594-019-0330-y
6NI3 (No Gprot) AAmineAdrenergicβ2Homo sapiensBI167107-3.82019-11-20doi.org/10.1038/s41594-019-0330-y
6OBAAAmineAdrenergicβ2Homo sapiensAlprenololGTPL11074-3.12020-03-25doi.org/10.1038/s41589-020-0549-2
7BZ2AAmineAdrenergicβ2Homo sapiensArformoterol-Gs/β1/γ23.822020-08-05doi.org/10.1038/s41421-020-0176-9
7BZ2 (No Gprot) AAmineAdrenergicβ2Homo sapiensArformoterol-3.822020-08-05doi.org/10.1038/s41421-020-0176-9
7DHIAAmineAdrenergicβ2Homo sapiensSalbutamol-Gs/β1/γ23.262020-12-16doi.org/10.1093/nsr/nwaa284
7DHI (No Gprot) AAmineAdrenergicβ2Homo sapiensSalbutamol-3.262020-12-16doi.org/10.1093/nsr/nwaa284
7DHRAAmineAdrenergicβ2Homo sapiensIsoprenaline-Gs/β1/γ23.82020-12-16doi.org/10.1093/nsr/nwaa284
7DHR (No Gprot) AAmineAdrenergicβ2Homo sapiensIsoprenaline-3.82020-12-16doi.org/10.1093/nsr/nwaa284
7XKAAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.12023-04-26doi.org/10.1038/s41467-023-37808-y
8JJ8AAmineAdrenergicβ2Homo sapiensArformoterol--3.22023-09-06doi.org/10.1038/s41589-023-01389-0
8JJLAAmineAdrenergicβ2Homo sapiensOlodaterol--3.22023-09-06doi.org/10.1038/s41589-023-01389-0
8JJOAAmineAdrenergicβ2Homo sapiensAlprenolol--3.42023-09-06doi.org/10.1038/s41589-023-01389-0
8GE2AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ13.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE2 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE5AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ13.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GE5 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.22024-03-06doi.org/10.1038/s41586-024-07153-1
9CHUAAmineAdrenergicβ2Homo sapiensNorepinephrine--3.492024-11-13doi.org/10.1073/pnas.2414544121
9CHVAAmineAdrenergicβ2Homo sapiens---3.952024-11-13doi.org/10.1073/pnas.2414544121
9U9VAAmineAdrenergicβ2Homo sapiensMETH-Gs/β1/γ22.852025-09-03To be published
9U9V (No Gprot) AAmineAdrenergicβ2Homo sapiensMETH-2.852025-09-03To be published
7XK9AAmineAdrenergicβ2Homo sapiensConstrained IsoproterenolNa-3.42023-04-26doi.org/10.1038/s41467-023-37808-y
8GDZAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GDZ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GE1AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE1 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE3AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE3 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE4AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE4 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE6AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE6 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE7AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE7 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE8AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE8 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE9AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GE9 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEAAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEA (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEBAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GEB (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GECAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEC (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEDAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GED (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEEAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.72024-03-06doi.org/10.1038/s41586-024-07153-1
8GEE (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.72024-03-06doi.org/10.1038/s41586-024-07153-1
8GEFAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEF (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEGAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEG (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEHAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ242024-03-06doi.org/10.1038/s41586-024-07153-1
8GEH (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-42024-03-06doi.org/10.1038/s41586-024-07153-1
8GEIAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ24.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GEI (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-4.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GEJAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ24.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GEJ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-4.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GFVAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GFV (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GFWAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFW (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GFXAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFX (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GFYAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFY (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GFZAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFZ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG0AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ22.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GG0 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP2.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GG1AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GG1 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG2AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GG2 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG3AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GG3 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GG4AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG4 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG5AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG5 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG6AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG6 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG7AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG7 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG8AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG8 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG9AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GG9 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGAAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGA (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGBAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGB (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGCAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGC (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGEAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGE (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGFAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GGF (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GGIAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGJAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGKAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GGLAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGMAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGNAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GGOAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGPAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGQAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGRAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGSAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGTAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGUAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGVAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGWAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GGXAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GGYAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GGZAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GH0AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--42024-03-06doi.org/10.1038/s41586-024-07153-1
8GH1AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--4.12024-03-06doi.org/10.1038/s41586-024-07153-1
8UNLAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNL (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNMAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNM (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNNAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNN (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNOAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNO (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNPAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNP (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNQAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNQ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNRAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNR (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNSAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNS (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNTAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNT (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNUAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UNU (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UNVAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNV (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNWAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNW (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNXAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNX (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNYAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNY (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNZAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.82024-03-06doi.org/10.1038/s41586-024-07153-1
8UNZ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.82024-03-06doi.org/10.1038/s41586-024-07153-1
8UO0AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO0 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO1AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; MgGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO1 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; Mg3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO2AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO2 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO3AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; MgGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO3 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; Mg3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO4AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; MgGs/β1/γ242024-03-06doi.org/10.1038/s41586-024-07153-1
8UO4 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; Mg42024-03-06doi.org/10.1038/s41586-024-07153-1
8W1VAAmineAdrenergicβ2Homo sapiensPubChem 171716265--32024-07-17doi.org/10.1021/acs.jmedchem.4c00578
9CHXAAmineAdrenergicβ2Homo sapiensCarazolol--3.52024-11-13doi.org/10.1073/pnas.2414544121
9BUYAAmineAdrenergicβ2Homo sapiensLM189-Gi1/β1/γ22.92025-05-28doi.org/10.1126/sciadv.adq3971
9BUY (No Gprot) AAmineAdrenergicβ2Homo sapiensLM189-2.92025-05-28doi.org/10.1126/sciadv.adq3971
9M55AAmineAdrenergicOct-Beta2Ixodes scapularisDPMF-chim(NtGi1-Gs)/β1/γ23.392025-12-1710.1093/pnasnexus/pgaf376
9M55 (No Gprot) AAmineAdrenergicOct-Beta2Ixodes scapularisDPMF-3.392025-12-1710.1093/pnasnexus/pgaf376
9M57AAmineAdrenergicOct-Beta2Ixodes scapularisOctopamine-chim(NtGi1-Gs)/β1/γ23.652025-12-1710.1093/pnasnexus/pgaf376
9M57 (No Gprot) AAmineAdrenergicOct-Beta2Ixodes scapularisOctopamine-3.652025-12-1710.1093/pnasnexus/pgaf376
9L8LAAmineAdrenergicβ2Homo sapiensBI167107AtazanavirGs/β1/γ2 ; Arrestin23.222025-12-31To be published
9L8L (No Gprot) AAmineAdrenergicβ2Homo sapiensBI167107Atazanavir3.222025-12-31To be published




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