Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:I47 3.08571718
2R:R:L64 4.004538
3R:R:N69 5.44439
4R:R:F71 4.9748
5R:R:L75 3.6425409
6R:R:D79 7.295419
7R:R:M82 6.3625417
8R:R:T118 5.57406
9R:R:D130 5.885448
10R:R:R131 8.578529
11R:R:Y132 5.76408
12R:R:Y141 8.028527
13R:R:L230 7.0975425
14R:R:E237 4.155403
15R:R:F264 7.38524
16R:R:H269 5.996525
17R:R:F282 9.0675419
18R:R:W286 10.296518
19R:R:F290 13.39407
20R:R:Y316 5.065416
21R:R:N318 6.845419
22R:R:S319 6.0225419
23R:R:Y326 9.975439
24R:R:P330 5.89435
25R:R:F332 8.25539
26R:R:F336 5.17407
27R:R:L339 4.338556
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:G320 R:R:I47 11.66471.76NoYes078
2R:R:I43 R:R:I47 11.51731.47NoYes068
3R:R:G83 R:R:I47 13.54173.53NoYes078
4R:R:G83 R:R:V87 11.66473.68NoNo077
5R:R:D79 R:R:I47 14.6034.2YesYes198
6R:R:I47 R:R:S319 23.87976.19YesYes189
7R:R:I55 R:R:T56 10.98661.52NoNo075
8R:R:L339 R:R:T56 15.99842.95YesNo065
9R:R:F336 R:R:L53 10.34794.87YesNo076
10R:R:F332 R:R:F336 28.586911.79YesYes097
11R:R:F332 R:R:P330 57.43912.89YesYes395
12R:R:P330 R:R:S329 61.4785.34YesNo358
13R:R:K273 R:R:S329 67.3844.59NoNo078
14R:R:K270 R:R:K273 68.5247.18NoNo077
15R:R:H269 R:R:K270 69.64432.62YesNo057
16R:R:F264 R:R:H269 71.94385.66YesYes245
17R:R:F264 R:R:Y141 79.3739.28YesYes247
18R:R:R131 R:R:Y141 84.895811.32YesYes297
19R:R:L275 R:R:R131 87.06768.5NoYes289
20R:R:I278 R:R:L275 89.15092.85NoNo088
21R:R:I278 R:R:N322 91.18515.66NoNo089
22R:R:D79 R:R:N322 91.81412.69YesNo099
23R:R:A76 R:R:T73 12.11671.68NoNo096
24R:R:A76 R:R:V54 13.83653.39NoNo099
25R:R:F336 R:R:V54 15.61522.62YesNo079
26R:R:F61 R:R:L64 15.31054.87NoYes068
27R:R:F332 R:R:L64 26.3076.09YesYes398
28R:R:F71 R:R:I154 24.61676.28YesNo088
29R:R:I154 R:R:S74 26.23823.1NoNo089
30R:R:L75 R:R:S74 35.44613YesNo099
31R:R:L75 R:R:S120 65.95913YesNo099
32R:R:F282 R:R:S120 66.75519.25YesNo099
33R:R:F282 R:R:N318 81.18128.46YesYes199
34R:R:N318 R:R:S319 1004.47YesYes199
35R:R:F71 R:R:I153 10.84916.28YesNo086
36R:R:L75 R:R:T123 21.35424.42YesNo098
37R:R:L124 R:R:L75 26.16944.15NoYes089
38R:R:C116 R:R:M82 12.43124.86NoYes077
39R:R:M82 R:R:S319 21.79644.6YesYes179
40R:R:T123 R:R:V157 19.67374.76NoNo087
41R:R:A119 R:R:V157 18.07191.7NoNo077
42R:R:A119 R:R:S161 16.35223.42NoNo078
43R:R:S161 R:R:T118 11.07514.8NoYes086
44R:R:N318 R:R:W286 17.885211.3YesYes198
45R:R:F282 R:R:I121 32.39987.54YesNo097
46R:R:I121 R:R:L212 26.62155.71NoNo077
47R:R:L124 R:R:M215 24.73475.65NoNo088
48R:R:M215 R:R:V216 21.023.04NoNo085
49R:R:L212 R:R:V216 21.90452.98NoNo075
50R:R:F133 R:R:V129 15.51692.62NoNo056
51R:R:F133 R:R:Y132 18.56332.06NoYes058
52R:R:V222 R:R:Y132 27.58453.79NoYes088
53R:R:V222 R:R:Y219 30.55232.52NoNo089
54R:R:M279 R:R:Y219 33.392317.96NoNo789
55R:R:M215 R:R:M279 39.33774.33NoNo088
56R:R:F290 R:R:W286 25.98273.01YesYes078
57R:R:F208 R:R:F290 21.275636.44NoYes087
58R:R:F208 R:R:L287 11.91042.44NoNo086
59R:R:D79 R:R:S319 78.24298.83YesYes199
60R:R:F282 R:R:W286 12.971711.02YesYes198
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 3KJ6
Class A
SubFamily Amine
Type Adrenergic
SubType Beta2
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.4
Date 2010-02-16
D.O.I. 10.1038/nature08650
Net Summary
Imin 2.62
Number of Linked Nodes 206
Number of Links 221
Number of Hubs 27
Number of Links mediated by Hubs 99
Number of Communities 7
Number of Nodes involved in Communities 41
Number of Links involved in Communities 52
Path Summary
Number Of Nodes in MetaPath 61
Number Of Links MetaPath 60
Number of Shortest Paths 19464
Length Of Smallest Path 3
Average Path Length 14.8677
Length of Longest Path 35
Minimum Path Strength 1.285
Average Path Strength 5.70185
Maximum Path Strength 21.97
Minimum Path Correlation 0.7
Average Path Correlation 0.932541
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.84615
Average % Of Corr. Nodes 47.5343
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.1194
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• amide binding   • amyloid-beta binding   • binding   • peptide binding   • protein binding   • enzyme binding   • adenylate cyclase binding   • G protein-coupled amine receptor activity   • molecular transducer activity   • beta2-adrenergic receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • beta-adrenergic receptor activity   • adrenergic receptor activity   • protein-containing complex binding   • monoatomic cation transmembrane transporter activity   • channel regulator activity   • ion channel regulator activity   • monoatomic ion channel activity   • potassium ion transmembrane transporter activity   • potassium channel activity   • potassium channel regulator activity   • monoatomic cation channel activity   • passive transmembrane transporter activity   • inorganic molecular entity transmembrane transporter activity   • channel activity   • molecular function regulator activity   • inorganic cation transmembrane transporter activity   • monoatomic ion transmembrane transporter activity   • transporter activity   • transporter regulator activity   • metal ion transmembrane transporter activity   • transmembrane transporter activity   • identical protein binding   • protein homodimerization activity   • protein dimerization activity   • cation binding   • ion binding   • catecholamine binding   • norepinephrine binding   • small molecule binding   • multicellular organismal process   • response to nutrient levels   • response to stimulus   • homeostatic process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • response to dietary excess   • diet induced thermogenesis   • metabolic process   • cellular process   • energy homeostasis   • response to stress   • response to abiotic stimulus   • response to cold
Gene OntologyBiological Process• multicellular organismal process   • response to nutrient levels   • response to stimulus   • homeostatic process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • response to dietary excess   • diet induced thermogenesis   • metabolic process   • cellular process   • energy homeostasis   • response to stress   • response to abiotic stimulus   • response to cold   • response to temperature stimulus   • regulation of developmental process   • positive regulation of biological process   • regulation of biomineral tissue development   • regulation of bone mineralization   • positive regulation of ossification   • positive regulation of developmental process   • multicellular organism development   • positive regulation of biomineral tissue development   • ossification   • anatomical structure development   • biomineral tissue development   • regulation of multicellular organismal process   • developmental process   • regulation of multicellular organismal development   • regulation of biological process   • bone mineralization   • animal organ development   • biological regulation   • tissue development   • positive regulation of bone mineralization   • positive regulation of multicellular organismal process   • regulation of ossification   • regulation of multicellular organism growth   • regulation of growth   • regulation of developmental growth   • negative regulation of multicellular organism growth   • developmental growth   • negative regulation of developmental process   • growth   • negative regulation of biological process   • multicellular organism growth   • negative regulation of developmental growth   • negative regulation of growth   • negative regulation of multicellular organismal process   • cellular response to stimulus   • adenylate cyclase-activating adrenergic receptor signaling pathway   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adrenergic receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • fat cell differentiation   • cellular developmental process   • brown fat cell differentiation   • cell differentiation   • system process   • regulation of system process   • muscle contraction   • muscle system process   • regulation of muscle system process   • negative regulation of muscle contraction   • smooth muscle contraction   • regulation of smooth muscle contraction   • regulation of muscle contraction   • negative regulation of smooth muscle contraction   • positive regulation of DNA-templated transcription   • RNA metabolic process   • positive regulation of macromolecule biosynthetic process   • regulation of primary metabolic process   • nucleobase-containing compound metabolic process   • RNA biosynthetic process   • nucleic acid biosynthetic process   • positive regulation of metabolic process   • DNA-templated transcription   • regulation of RNA metabolic process   • transcription by RNA polymerase II   • positive regulation of biosynthetic process   • positive regulation of macromolecule metabolic process   • regulation of nucleobase-containing compound metabolic process   • positive regulation of cellular process   • regulation of RNA biosynthetic process   • regulation of biosynthetic process   • regulation of transcription by RNA polymerase II   • positive regulation of nucleobase-containing compound metabolic process   • primary metabolic process   • regulation of macromolecule metabolic process   • positive regulation of transcription by RNA polymerase II   • nucleobase-containing compound biosynthetic process   • gene expression   • macromolecule biosynthetic process   • nucleic acid metabolic process   • positive regulation of RNA metabolic process   • regulation of gene expression   • biosynthetic process   • positive regulation of RNA biosynthetic process   • regulation of macromolecule biosynthetic process   • macromolecule metabolic process   • regulation of DNA-templated transcription   • regulation of metabolic process   • tissue remodeling   • bone remodeling   • anatomical structure homeostasis   • tissue homeostasis   • bone resorption   • positive regulation of phosphorylation   • regulation of catalytic activity   • regulation of transferase activity   • positive regulation of phosphate metabolic process   • cell surface receptor protein tyrosine kinase signaling pathway   • cellular component biogenesis   • cellular component assembly   • regulation of phosphate metabolic process   • phosphate-containing compound metabolic process   • phosphorus metabolic process   • protein modification process   • positive regulation of protein phosphorylation   • activation of transmembrane receptor protein tyrosine kinase activity   • protein phosphorylation   • positive regulation of phosphorus metabolic process   • phosphorylation   • regulation of protein metabolic process   • regulation of molecular function   • positive regulation of kinase activity   • regulation of kinase activity   • activation of protein kinase activity   • macromolecule modification   • regulation of phosphorus metabolic process   • regulation of protein modification process   • regulation of protein phosphorylation   • positive regulation of protein metabolic process   • cellular component organization   • positive regulation of molecular function   • positive regulation of protein modification process   • protein-containing complex assembly   • cellular component organization or biogenesis   • protein metabolic process   • positive regulation of protein kinase activity   • enzyme-linked receptor protein signaling pathway   • positive regulation of transferase activity   • cell surface receptor signaling pathway   • protein-containing complex organization   • positive regulation of catalytic activity   • regulation of protein kinase activity   • regulation of phosphorylation   • localization   • import into cell   • transport   • receptor-mediated endocytosis   • endocytosis   • establishment of localization   • vesicle-mediated transport   • cellular localization   • endosome to lysosome transport   • intracellular transport   • lysosomal transport   • establishment of localization in cell   • vacuolar transport   • positive regulation of organelle organization   • catabolic process   • regulation of cellular component organization   • positive regulation of cellular component organization   • regulation of autophagosome maturation   • macroautophagy   • autophagy   • protein-containing complex disassembly   • regulation of autophagy   • regulation of protein-containing complex disassembly   • autophagosome maturation   • positive regulation of macroautophagy   • process utilizing autophagic mechanism   • positive regulation of protein-containing complex disassembly   • cellular component disassembly   • positive regulation of autophagy   • regulation of catabolic process   • positive regulation of autophagosome maturation   • regulation of organelle organization   • positive regulation of catabolic process   • organelle organization   • regulation of macroautophagy   • lipophagy   • positive regulation of lipophagy   • regulation of lipophagy   • response to psychosocial stress   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • intracellular signal transduction   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • intracellular signaling cassette   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • MAPK cascade   • regulation of cell communication   • positive regulation of signaling   • ligand-gated ion channel signaling pathway   • ionotropic glutamate receptor signaling pathway   • glutamate receptor signaling pathway   • AMPA selective glutamate receptor signaling pathway   • regulation of tube diameter   • regulation of systemic arterial blood pressure mediated by a chemical signal   • regulation of blood pressure   • regulation of tube size   • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure   • negative regulation of blood pressure   • regulation of systemic arterial blood pressure by norepinephrine-epinephrine   • regulation of systemic arterial blood pressure   • circulatory system process   • negative regulation of systemic arterial blood pressure   • vascular process in circulatory system   • regulation of biological quality   • blood vessel diameter maintenance   • vasodilation   • blood circulation   • regulation of anatomical structure size   • negative regulation of signaling   • negative regulation of response to stimulus   • negative regulation of signal transduction   • negative regulation of G protein-coupled receptor signaling pathway   • negative regulation of cell communication   • negative regulation of cellular process   • regulation of G protein-coupled receptor signaling pathway   • positive regulation of cAMP/PKA signal transduction   • cAMP/PKA signal transduction   • regulation of cAMP/PKA signal transduction   • cellular response to nitrogen compound   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to amyloid-beta   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • response to chemical   • response to amyloid-beta   • regulation of localization   • regulation of transport   • regulation of monoatomic ion transport   • regulation of sodium ion transport   • metal ion transport   • monoatomic ion transport   • regulation of metal ion transport   • monoatomic cation transport   • sodium ion transport   • heat generation   • regulation of postsynaptic membrane potential   • modulation of chemical synaptic transmission   • positive regulation of excitatory postsynaptic potential   • chemical synaptic transmission, postsynaptic   • synaptic signaling   • modulation of excitatory postsynaptic potential   • mini excitatory postsynaptic potential   • trans-synaptic signaling   • nervous system process   • cell-cell signaling   • chemical synaptic transmission   • regulation of nervous system process   • regulation of mini excitatory postsynaptic potential   • positive regulation of mini excitatory postsynaptic potential   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • excitatory postsynaptic potential   • regulation of membrane potential   • cellular anatomical structure   • membrane   • membrane-bounded organelle   • intracellular anatomical structure   • dense core granule   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • cytoplasmic vesicle   • organelle   • secretory granule   • secretory vesicle   • cytoplasm
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • membrane-bounded organelle   • intracellular anatomical structure   • dense core granule   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • cytoplasmic vesicle   • organelle   • secretory granule   • secretory vesicle   • cytoplasm   • vesicle   • neuronal dense core vesicle   • bounding membrane of organelle   • vesicle membrane   • clathrin-coated vesicle   • endocytic vesicle membrane   • coated vesicle   • endocytic vesicle   • clathrin-coated vesicle membrane   • clathrin-coated endocytic vesicle membrane   • clathrin-coated endocytic vesicle   • cytoplasmic vesicle membrane   • coated vesicle membrane   • organelle membrane   • protein-containing complex   • receptor complex   • Golgi apparatus   • endosome membrane   • endosome   • cell periphery   • apical part of cell   • plasma membrane   • plasma membrane region   • apical plasma membrane   • lytic vacuole   • vacuole   • lysosome   • early endosome   • nucleus
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP07550
Sequence
>3KJ6_Chain_R
GMGIVMSLI VLAIVFGNV LVITAIAFE RLQTVTNYF ITSLACADL 
VMGLAVVPF GAFWTSIDV LCVTASIET LCVIAVDRY FAITSPFKY 
QSLLTKNKA RVIILMVWI VSGLTSSIV SFYVPLVIM VFVYSRVFQ 
EAKRQLQKI DKSEGRFHV KFCLKEHKA LKTLGIIMG TFTLCWLPF 
FIVYILLNW IGYVNSGFN PLIYCRSPD FRIAFQELL CLRRSS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9CHVAAmineAdrenergicβ2Homo sapiens---3.952024-11-1310.1073/pnas.2414544121
9CHUAAmineAdrenergicβ2Homo sapiensNoradrenaline--3.492024-11-1310.1073/pnas.2414544121
9CHXAAmineAdrenergicβ2Homo sapiensS-Carazolol--3.52024-11-1310.1073/pnas.2414544121
8W1VAAmineAdrenergicβ2Homo sapiensPubChem 171716265--32024-07-17doi.org/10.1021/acs.jmedchem.4c00578
8W1V (Multimeric) AAmineAdrenergicβ2Homo sapiensPubChem 171716265-32024-07-17doi.org/10.1021/acs.jmedchem.4c00578
8GH1AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--4.12024-03-0610.1038/s41586-024-07153-1
8GH0AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--42024-03-0610.1038/s41586-024-07153-1
8GGZAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.92024-03-0610.1038/s41586-024-07153-1
8GGYAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.92024-03-0610.1038/s41586-024-07153-1
8GGXAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.62024-03-0610.1038/s41586-024-07153-1
8GGWAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.62024-03-0610.1038/s41586-024-07153-1
8GGVAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGUAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGTAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGSAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGRAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGQAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGPAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGOAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGNAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.32024-03-0610.1038/s41586-024-07153-1
8GGMAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGLAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGKAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.32024-03-0610.1038/s41586-024-07153-1
8GGJAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGIAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8UO4AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; MgGs/β1/γ242024-03-0610.1038/s41586-024-07153-1
8UO3AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; MgGs/β1/γ23.52024-03-0610.1038/s41586-024-07153-1
8UO2AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-0610.1038/s41586-024-07153-1
8UO1AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; MgGs/β1/γ23.62024-03-0610.1038/s41586-024-07153-1
8UO0AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-0610.1038/s41586-024-07153-1
8UNZAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.82024-03-0610.1038/s41586-024-07153-1
8UNYAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-0610.1038/s41586-024-07153-1
8UNXAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-0610.1038/s41586-024-07153-1
8UNWAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-0610.1038/s41586-024-07153-1
8UNVAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-0610.1038/s41586-024-07153-1
8UNUAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-0610.1038/s41586-024-07153-1
8UNTAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-0610.1038/s41586-024-07153-1
8UNSAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-0610.1038/s41586-024-07153-1
8UNRAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-0610.1038/s41586-024-07153-1
8UNQAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-0610.1038/s41586-024-07153-1
8UNPAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-0610.1038/s41586-024-07153-1
8UNOAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-0610.1038/s41586-024-07153-1
8UNNAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-0610.1038/s41586-024-07153-1
8UNMAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-0610.1038/s41586-024-07153-1
8UNLAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-0610.1038/s41586-024-07153-1
8GGFAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-0610.1038/s41586-024-07153-1
8GGEAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-0610.1038/s41586-024-07153-1
8GGCAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-0610.1038/s41586-024-07153-1
8GGBAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-0610.1038/s41586-024-07153-1
8GGAAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-0610.1038/s41586-024-07153-1
8GG9AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-0610.1038/s41586-024-07153-1
8GG8AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-0610.1038/s41586-024-07153-1
8GG7AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-0610.1038/s41586-024-07153-1
8GG6AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-0610.1038/s41586-024-07153-1
8GG5AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.22024-03-0610.1038/s41586-024-07153-1
8GG4AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.22024-03-0610.1038/s41586-024-07153-1
8GG3AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.12024-03-0610.1038/s41586-024-07153-1
8GG2AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-0610.1038/s41586-024-07153-1
8GG1AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-0610.1038/s41586-024-07153-1
8GG0AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ22.92024-03-0610.1038/s41586-024-07153-1
8GFZAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-0610.1038/s41586-024-07153-1
8GFYAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-0610.1038/s41586-024-07153-1
8GFXAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-0610.1038/s41586-024-07153-1
8GFWAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-0610.1038/s41586-024-07153-1
8GFVAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.12024-03-0610.1038/s41586-024-07153-1
8GEJAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ24.22024-03-0610.1038/s41586-024-07153-1
8GEIAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ24.12024-03-0610.1038/s41586-024-07153-1
8GEHAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ242024-03-0610.1038/s41586-024-07153-1
8GEGAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.82024-03-0610.1038/s41586-024-07153-1
8GEFAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.82024-03-0610.1038/s41586-024-07153-1
8GEEAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.72024-03-0610.1038/s41586-024-07153-1
8GEDAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-0610.1038/s41586-024-07153-1
8GECAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-0610.1038/s41586-024-07153-1
8GEBAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.62024-03-0610.1038/s41586-024-07153-1
8GEAAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-0610.1038/s41586-024-07153-1
8GE9AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-0610.1038/s41586-024-07153-1
8GE8AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-0610.1038/s41586-024-07153-1
8GE7AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-0610.1038/s41586-024-07153-1
8GE6AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-0610.1038/s41586-024-07153-1
8GE4AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.32024-03-0610.1038/s41586-024-07153-1
8GE3AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.32024-03-0610.1038/s41586-024-07153-1
8GE1AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-0610.1038/s41586-024-07153-1
8GDZAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-0610.1038/s41586-024-07153-1
7XKAAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.12023-04-2610.1038/s41467-023-37808-y
7XK9AAmineAdrenergicβ2Homo sapiensConstrained IsoproterenolNa-3.42023-04-26doi.org/10.1038/s41467-023-37808-y
8JJOAAmineAdrenergicβ2Homo sapiensAlprenolol--3.42023-09-0610.1038/s41589-023-01389-0
8JJLAAmineAdrenergicβ2Homo sapiensOlodaterol--3.22023-09-0610.1038/s41589-023-01389-0
8JJ8AAmineAdrenergicβ2Homo sapiensFormoterol--3.22023-09-0610.1038/s41589-023-01389-0
7DHRAAmineAdrenergicβ2Homo sapiensIsoprenaline-Gs/β1/γ23.82020-12-1610.1093/nsr/nwaa284
7DHIAAmineAdrenergicβ2Homo sapiensSalbutamol-Gs/β1/γ23.262020-12-1610.1093/nsr/nwaa284
7BZ2AAmineAdrenergicβ2Homo sapiensArformoterol-Gs/β1/γ23.822020-08-0510.1038/s41421-020-0176-9
6OBAAAmineAdrenergicβ2Homo sapiensS-AlprenololGTPL11074-3.12020-03-2510.1038/s41589-020-0549-2
6NI3AAmineAdrenergicβ2Homo sapiensBI167107-Gs/β1/γ23.82019-11-2010.1038/s41594-019-0330-y
6PS6AAmineAdrenergicβ2Homo sapiensTimolol--2.72019-11-1310.1107/S2052252519013137
6PS5AAmineAdrenergicβ2Homo sapiensS-Propranolol--2.92019-11-1310.1107/S2052252519013137
6PS4AAmineAdrenergicβ2Homo sapiensICI118-551--2.62019-11-1310.1107/S2052252519013137
6PS3AAmineAdrenergicβ2Homo sapiensS-Carvedilol--2.52019-11-1310.1107/S2052252519013137
6PS2AAmineAdrenergicβ2Homo sapiensS-Alprenolol--2.42019-11-1310.1107/S2052252519013137
6PS1AAmineAdrenergicβ2Homo sapiensTimolol--3.22019-11-1310.1107/S2052252519013137
6PS0AAmineAdrenergicβ2Homo sapiensS-Carazolol--3.42019-11-1310.1107/S2052252519013137
6PRZAAmineAdrenergicβ2Homo sapiensS-Alprenolol--2.82019-11-1310.1107/S2052252519013137
6N48AAmineAdrenergicβ2Homo sapiensBI167107PubChem 138454256-3.22019-06-2610.1126/science.aaw8981
6E67AAmineAdrenergicβ2Homo sapiensBI167107-Gs (fused)3.72019-06-0510.1016/j.cell.2019.04.021
6MXTAAmineAdrenergicβ2Homo sapiensSalmeterol--2.962018-11-1410.1038/s41589-018-0145-x
5X7DAAmineAdrenergicβ2Homo sapiensS-CarazololPubChem 129318963-2.72017-08-1610.1038/nature23652
5D6LAAmineAdrenergicβ2Homo sapiensS-Carazolol--3.22016-08-1710.1038/nprot.2017.057
5JQHAAmineAdrenergicβ2Homo sapiensS-Carazolol--3.22016-07-1310.1038/nature18636
5D5BAAmineAdrenergicβ2Homo sapiensS-Carazolol--3.82016-01-1310.1107/S2059798315021683
5D5AAAmineAdrenergicβ2Homo sapiensS-Carazolol--2.482016-01-1310.1107/S2059798315021683
4QKXAAmineAdrenergicβ2Homo sapiens35V--3.32014-07-2310.1073/pnas.1410415111
4LDOAAmineAdrenergicβ2Homo sapiensL-Epinephrine--3.22013-09-2510.1038/nature12572
4LDLAAmineAdrenergicβ2Homo sapiensHydroxybenzylisoproterenol--3.12013-09-2510.1038/nature12572
4LDEAAmineAdrenergicβ2Homo sapiensBI167107--2.792013-09-2510.1038/nature12572
4GBRAAmineAdrenergicβ2Homo sapiensS-Carazolol--3.992012-10-2410.1371/journal.pone.0046039
3SN6AAmineAdrenergicβ2Homo sapiensBI167107-Gs/β1/γ23.22011-07-2010.1038/nature10361
3P0GAAmineAdrenergicβ2Homo sapiensBI167107--3.52011-01-1910.1038/nature09648
3PDSAAmineAdrenergicβ2Homo sapiensHydroxybenzylisoproterenol--3.52011-01-1210.1038/nature09665
3NYAAAmineAdrenergicβ2Homo sapiensS-Alprenolol--3.162010-08-1110.1021/ja105108q
3NY9AAmineAdrenergicβ2Homo sapiensICI118-551--2.842010-08-1110.1021/ja105108q
3NY8AAmineAdrenergicβ2Homo sapiensICI118-551--2.842010-08-1110.1021/ja105108q
3D4SAAmineAdrenergicβ2Homo sapiensTimolol--2.82008-06-1710.1016/j.str.2008.05.001
2R4SAAmineAdrenergicβ2Homo sapiens---3.42007-11-0610.1038/nature06325
2R4RAAmineAdrenergicβ2Homo sapiens---3.42007-11-0610.1038/nature06325
2RH1AAmineAdrenergicβ2Homo sapiensS-Carazolol--2.42007-10-3010.1126/science.1150577




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