Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:M40 2.7325406
2R:R:F61 5.525426
3R:R:L64 3.595428
4R:R:F71 4.135408
5R:R:S74 5.5525479
6R:R:D79 6.428559
7R:R:M82 3.9075407
8R:R:W99 8.556547
9R:R:D130 4.5925468
10R:R:Y132 8.238508
11R:R:W158 4.902579
12R:R:S165 3.905437
13R:R:F166 5.5325434
14R:R:Q170 1.51434
15R:R:Y174 6.5825435
16R:R:F194 7.68491
17R:R:Y199 3.2875436
18R:R:F208 10.836518
19R:R:P211 3.38408
20R:R:W286 5.08125818
21R:R:L287 3.1825406
22R:R:F289 7.136516
23R:R:F290 9.52517
24R:R:N293 3.855415
25R:R:H296 6.9825413
26R:R:Y316 7.158516
27R:R:N322 4.97459
28R:R:Y326 5.6025409
29R:R:F332 5.835629
30R:R:F336 5.5125427
31L:L:?1 9.19556910
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:M40 R:R:W313 23.27764.65YesNo065
2R:R:W313 R:R:Y316 60.32592.89NoYes056
3R:R:N312 R:R:Y316 15.121611.63NoYes156
4R:R:F289 R:R:N312 16.168512.08YesNo165
5R:R:F289 R:R:W286 55.34455.01YesYes168
6R:R:I121 R:R:W286 1004.7NoYes078
7R:R:I121 R:R:S207 73.5143.1NoNo075
8R:R:S207 R:R:T118 72.20536.4NoNo056
9R:R:S161 R:R:T118 70.97264.8NoNo086
10R:R:G162 R:R:S161 70.01863.71NoNo048
11R:R:G162 R:R:S165 69.49513.71NoYes047
12R:R:S111 R:R:S165 95.31413.26NoYes367
13R:R:I169 R:R:S111 95.773.1NoNo356
14R:R:I169 R:R:Y174 80.93559.67NoYes355
15R:R:Y174 R:R:Y185 77.05176.95YesNo051
16R:R:A181 R:R:Y185 71.04862.67NoNo041
17R:R:A181 R:R:F194 69.00545.55NoYes041
18R:R:D192 R:R:F194 55.817313.14NoYes931
19R:R:C184 R:R:D192 54.25534.67NoNo013
20R:R:C184 R:R:C190 52.0775.46NoNo013
21R:R:C190 R:R:E187 49.88183.04NoNo037
22R:R:E187 R:R:T189 42.89094.23NoNo874
23R:R:T189 R:R:T98 40.93213.14NoNo045
24R:R:T100 R:R:T98 38.65253.14NoNo025
25R:R:F101 R:R:T100 36.3562.59NoNo052
26R:R:F101 R:R:W99 31.712317.04NoYes057
27R:R:A92 R:R:W99 12.45362.59NoYes047
28L:L:?1 R:R:Y316 42.8744.73YesYes106
29L:L:?1 R:R:F289 24.48510.81YesYes106
30L:L:?1 R:R:V117 25.40537.21YesNo006
31R:R:V117 R:R:W286 32.46374.9NoYes068
32L:L:?1 R:R:F290 23.29455.9YesYes107
33R:R:F290 R:R:W286 26.13144.01YesYes178
34R:R:D79 R:R:S319 24.34148.83YesNo099
35R:R:D79 R:R:L75 11.2045.43YesNo599
36R:R:L75 R:R:T123 38.2057.37NoNo098
37R:R:S74 R:R:T123 37.26786.4YesNo098
38R:R:S74 R:R:W158 34.52386.18YesYes799
39R:R:L115 R:R:W158 43.55794.56NoYes059
40R:R:L115 R:R:S165 43.03456.01NoYes057
41R:R:V87 R:R:W313 32.99564.9NoNo075
42R:R:V44 R:R:V87 23.84333.21NoNo067
43R:R:C327 R:R:P323 34.77711.88NoNo079
44R:R:N322 R:R:P323 42.41811.63YesNo099
45R:R:L75 R:R:N322 27.98046.87NoYes599
46R:R:C327 R:R:F332 24.45969.78NoYes279
47R:R:F332 R:R:L64 11.08584.87YesYes298
48R:R:D130 R:R:F71 14.6152.39YesYes088
49R:R:F71 R:R:I127 21.47083.77YesNo089
50R:R:I127 R:R:R131 23.80112.51NoNo099
51R:R:R131 R:R:Y326 25.86128.23NoYes099
52R:R:N322 R:R:Y326 38.65254.65YesYes099
53R:R:I154 R:R:W158 12.03994.7NoYes789
54R:R:M82 R:R:V117 18.05983.04YesNo076
55R:R:M82 R:R:S319 24.03753.07YesNo079
56R:R:M82 R:R:V86 10.3093.04YesNo077
57R:R:H93 R:R:W109 10.10643.17NoNo045
58R:R:H93 R:R:W99 12.521112.7NoYes447
59L:L:?1 R:R:F193 10.891612.77YesNo004
60R:R:I121 R:R:P211 42.00443.39NoYes078
61R:R:E122 R:R:P211 16.59914.72NoYes058
62R:R:E122 R:R:V157 15.90682.85NoNo057
63R:R:I154 R:R:V157 15.18073.07NoNo087
64R:R:F282 R:R:L124 51.31718.53NoNo098
65R:R:F282 R:R:W286 48.64917.02NoYes098
66R:R:L124 R:R:Y326 42.954.69NoYes089
67R:R:L124 R:R:M215 24.45967.07NoNo088
68R:R:C125 R:R:P211 38.8721.88NoYes078
69R:R:A128 R:R:M215 21.80854.83NoNo088
70R:R:A128 R:R:Y219 19.14054NoNo089
71R:R:F133 R:R:V129 31.39995.24NoNo056
72R:R:C125 R:R:V129 33.90751.71NoNo076
73R:R:F133 R:R:Y132 28.87545.16NoYes058
74R:R:T136 R:R:Y132 10.731217.48NoYes078
75R:R:F166 R:R:Q170 10.01351.17YesYes344
76R:R:H296 R:R:N293 23.21016.38YesYes135
77R:R:F289 R:R:N293 29.3062.42YesYes165
78R:R:F208 R:R:W286 16.1014.01YesYes188
79R:R:F208 R:R:L287 18.90413.65YesYes086
80R:R:L275 R:R:Y219 11.03514.69NoNo089
81R:R:H296 R:R:I303 17.14792.65YesNo033
82R:R:V44 R:R:V48 19.10671.6NoNo066
83R:R:V48 R:R:V52 14.35331.6NoNo063
84R:R:D79 R:R:N322 13.29796.73YesYes599
85R:R:F166 R:R:S165 12.55492.64YesYes347
86R:R:I169 R:R:Y199 13.00244.84NoYes356
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 3.04 0 Yes No 7 7 2 2
R:R:M82 R:R:V117 3.04 0 Yes No 7 6 2 1
R:R:D113 R:R:V86 10.22 1 No No 7 7 1 2
R:R:V86 R:R:Y316 5.05 1 No Yes 7 6 2 1
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
R:R:D113 R:R:Y316 11.49 1 No Yes 7 6 1 1
L:L:?1 R:R:D113 9.85 1 Yes No 0 7 0 1
L:L:?1 R:R:V114 10.82 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:F193 R:R:T195 6.49 0 No No 4 3 1 2
L:L:?1 R:R:F193 12.77 1 Yes No 0 4 0 1
L:L:?1 R:R:S203 8.48 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 6.61 1 Yes No 7 5 1 2
R:R:F208 R:R:W286 4.01 1 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 25.72 1 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 5.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 5.36 1 Yes Yes 6 7 1 1
R:R:F289 R:R:N312 12.08 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 10.81 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.9 1 Yes Yes 0 7 0 1
R:R:N312 R:R:Y316 11.63 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 12.19 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 2.89 0 No Yes 5 6 2 1
L:L:?1 R:R:Y316 4.73 1 Yes Yes 0 6 0 1
R:R:F289 R:R:N293 2.42 1 Yes Yes 6 5 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
100.00Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
100.00Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
100.00Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
100.00Single8GGVEpinephrine8GGV-β2-Epinephrine
100.00Single8GH0Epinephrine8GH0-β2-Epinephrine
90.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
90.00Single6PS4ICI 118-5516PS4-β2-ICI 118-551
90.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
90.00Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
90.00Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
90.00Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
90.00Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
90.00Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
90.00Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
90.00Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
90.00Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.00Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.00Single8GGIEpinephrine8GGI-β2-Epinephrine
90.00Single8GGQEpinephrine8GGQ-β2-Epinephrine
90.00Single8GGTEpinephrine8GGT-β2-Epinephrine
90.00Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.00Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
88.89Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
88.89Single8GGSEpinephrine8GGS-β2-Epinephrine
88.89Single8GGYEpinephrine8GGY-β2-Epinephrine
88.89Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
88.89Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single2Y04Salbutamol2Y04-β1-Salbutamol
81.82Single3NY8ICI 118-5513NY8-β2-ICI 118-551
81.82Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
81.82Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
81.82Single6H7MSalbutamol6H7M-β1-Salbutamol
81.82Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
81.82Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
81.82Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
81.82Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
81.82Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GGJEpinephrine8GGJ-β2-Epinephrine
81.82Single8GGNEpinephrine8GGN-β2-Epinephrine
81.82Single8GGOEpinephrine8GGO-β2-Epinephrine
81.82Single8GGUEpinephrine8GGU-β2-Epinephrine
81.82Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
81.82Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
81.82Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
81.82Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
80.00Single6KUXRS-799486KUX-α2a-RS-79948
80.00Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
80.00Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
80.00Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
80.00Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
80.00Single8GGWEpinephrine8GGW-β2-Epinephrine
80.00Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
80.00Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
80.00Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
80.00Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
80.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
80.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
80.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
80.00Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
80.00Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
80.00Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
77.78Single8GGREpinephrine8GGR-β2-Epinephrine
77.78Single8GGZEpinephrine8GGZ-β2-Epinephrine
77.78Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
75.00Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
75.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
75.00Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
75.00Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
75.00Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
75.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
75.00Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
75.00Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
75.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
75.00Single7XKAEpinephrine7XKA-β2-Epinephrine
75.00Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
75.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
75.00Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
75.00Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
75.00Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
75.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
75.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
75.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
75.00Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
75.00Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
75.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
72.73Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
72.73Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
72.73Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
72.73Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
72.73Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GGKEpinephrine8GGK-β2-Epinephrine
72.73Single8GGMEpinephrine8GGM-β2-Epinephrine
72.73Single8GGPEpinephrine8GGP-β2-Epinephrine
72.73Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
72.73Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
72.73Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
72.73Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
72.73Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
72.73Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
70.00Single3PBLEticlopride3PBL-D3-Eticlopride
70.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
70.00Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
70.00Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
70.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
70.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
70.00Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
69.23Single2YDVNECA2YDV-A2A-NECA
69.23Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
69.23Single4UHRCGS216804UHR-A2A-CGS21680
69.23Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
69.23Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
69.23Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
69.23Single5G53NECA5G53-A2A-NECA-Gs
69.23Single6H7JIsoprenaline6H7J-β1-Isoprenaline
69.23Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
69.23Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
69.23Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
69.23Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
69.23Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
69.23Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
69.23Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
69.23Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
69.23Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
69.23Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
69.23Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
66.67Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
66.67Single2Y01Dobutamine2Y01-β1-Dobutamine
66.67Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
66.67Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
66.67Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
66.67Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
66.67Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
66.67Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
66.67Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
66.67Single6PS1Timolol6PS1-β2-Timolol
66.67Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
66.67Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
66.67Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
66.67Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
66.67Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
66.67Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
66.67Single7WC7Lisuride7WC7-5-HT2A-Lisuride
66.67Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
66.67Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
66.67Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
66.67Single8JJOAlprenolol8JJO-β2-Alprenolol
66.67Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
66.67Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
66.67Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
66.67Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
66.67Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
66.67Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
66.67Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
66.67Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
66.67Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
66.67Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
66.67Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
66.67Consensustar_onOrthosteric Ligandta1_on
64.29Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
64.29Single4AMIBucindolol4AMI-β1-Bucindolol
64.29Single4LDEBI1671074LDE-β2-BI167107
64.29Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
64.29Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
64.29Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
64.29Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
64.29Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
64.29Single8JJ8Formoterol8JJ8-β2-Formoterol
64.29Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
64.29Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
64.29Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
63.64Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
63.64Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
63.64Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
63.64Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
63.64Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
63.64Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
63.64Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
63.64Single8IWESpermidine8IWE-TAAR9-Spermidine
63.64Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
63.64Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
63.64Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
63.64Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
63.64Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
63.64Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
61.54Single2Y00Dobutamine2Y00-β1-Dobutamine
61.54Single5C1MBU725C1M-μ-BU72
61.54Single5TVNLSD5TVN-5-HT2B-LSD
61.54Single5WIUNemonapride5WIU-D4-Nemonapride
61.54Single5WIVNemonapride5WIV-D4-Nemonapride-Na
61.54Single6E67BI1671076E67-β2-BI167107-Gs (fused)
61.54Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
61.54Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
61.54Single6PS6Timolol6PS6-β2-Timolol
61.54Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
61.54Single7WC6LSD7WC6-5-HT2A-LSD
61.54Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
61.54Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
61.54Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
61.54Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
61.54Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
61.54Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
61.54Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
61.54Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
61.54Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
60.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
60.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
60.00Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
60.00Single6H7LDobutamine6H7L-β1-Dobutamine
60.00Single6IBLArformoterol6IBL-β1-Arformoterol
60.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
60.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
60.00Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
60.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
60.00Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
58.33Single6A94Zotepine6A94-5-HT2A-Zotepine
58.33Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
58.33Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
58.33Single6TPGEMPA6TPG-OX2-EMPA
58.33Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
58.33Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
58.33Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
58.33Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
58.33Single8GGLEpinephrine8GGL-β2-Epinephrine
58.33Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
58.33Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
58.33Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
58.33Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
58.33Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
58.33Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
58.33Consensus5ht5_onOrthosteric Ligand5ht5a_on
58.33Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
58.33Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
58.33Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
57.14Single3P0GBI1671073P0G-β2-BI167107
57.14Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
57.14Single4RWADIPP-NH24RWA-δ-DIPP-NH2
57.14Single4U15Tiotropium4U15-M3-Tiotropium
57.14Single5V54Methiothepin5V54-5-HT1B-Methiothepin
57.14Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
57.14Single6J21Aprepitant6J21-NK1-Aprepitant
57.14Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
57.14Single6OL9Tiotropium6OL9-M5-Tiotropium
57.14Single6WGTLSD6WGT-5-HT2A-LSD
57.14Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
57.14Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
57.14Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
57.14Single8E0GBU728E0G-μ-BU72
57.14Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
57.14Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
57.14Consensus5ht1_offOrthosteric Ligand5ht1b_off
57.14Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
57.14Consensus5ht5_offOrthosteric Ligand5ht5a_off
57.14Consensusa2_onOrthosteric Liganda2a_on a2b_on
57.14Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
57.14Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
57.14Consensushistamine_offOrthosteric Ligandh1_off
57.14Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
57.14Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
56.25Single3NY9PubChem 9131033NY9-β2-PubChem 913103
56.25Single4UG2CGS216804UG2-A2A-CGS21680
56.25Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
55.56Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
54.55Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
54.55Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
54.55Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
54.55Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
54.55Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
54.55Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
54.55Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
54.55Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
54.55Single8GH1Epinephrine8GH1-β2-Epinephrine
54.55Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
54.55Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
54.55Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
54.55Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
54.55Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
54.55Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
53.85Single2Y02Carmoterol2Y02-β1-Carmoterol
53.85Single4EJ4Naltrindole4EJ4-δ-Naltrindole
53.85Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
53.85Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
53.85Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
53.85Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
53.85Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
53.85Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
53.85Single7BU7BI1671077BU7-β1-BI167107
53.85Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
53.85Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
53.85Single7UL4Alvimopan7UL4-μ-Alvimopan
53.85Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
53.85Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
53.85Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
53.85Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
53.85Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
53.85Single8X64Desloratadine8X64-H1-Desloratadine
53.85Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
53.85Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
53.85Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
53.85Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
53.85Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
53.85Consensushistamine_onOrthosteric Ligandh1_on h4_on
53.33Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
53.33Single5CXVTiotropium5CXV-M1-Tiotropium
53.33Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
53.33Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
53.33Single6MXTSalmeterol6MXT-β2-Salmeterol
53.33Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
53.33Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
53.33Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
53.33Single7YITNalfurafine7YIT-κ-Nalfurafine
53.33Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
53.33Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
53.33Single8JJLOlodaterol8JJL-β2-Olodaterol
53.33Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
53.33Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
53.33Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
53.33Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
53.33Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
52.94Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
52.94Single4IARErgotamine4IAR-5-HT1B-Ergotamine
52.94Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
52.94Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
50.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
50.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
50.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
50.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
50.00Single5WQCEMPA5WQC-OX2-EMPA
50.00Single6AKXA4R6AKX-CCR5-A4R
50.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
50.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
50.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
50.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
50.00Single6TODEMPA6TOD-OX1-EMPA-Na
50.00Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
50.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
50.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
50.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
50.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
50.00Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
50.00Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
50.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
50.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
50.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
50.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
50.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
50.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
50.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
50.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
50.00Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
50.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
50.00Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
50.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
50.00Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
50.00Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
50.00Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
50.00Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
50.00Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
50.00Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
50.00Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
50.00Consensusendothelin_offOrthosteric Ligandetb_off
50.00Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
50.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
50.00Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
50.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
50.00Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
50.00Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
50.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Consensussensory_onOrthosteric Ligandopsin_on
47.06Single6PT3DPI-2876PT3-δ-DPI-287
47.06Single7SK9CCX6627SK9-ACKR3-CCX662
47.06Single8X5YAstemizole8X5Y-H1-Astemizole
46.67Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
46.67Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
46.67Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
46.67Single5X93K-87945X93-ETB-K-8794
46.67Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
46.67Single6TQ7SB-3348676TQ7-OX1-SB-334867
46.67Single7B6WCyclazosin7B6W-α1b-Cyclazosin
46.67Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
46.67Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
46.67Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
46.67Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
46.67Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
46.67Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
46.67Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
46.67Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
46.67Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
46.67Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
46.67Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
46.67Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
46.67Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
46.67Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
46.67Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
46.67Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
46.67Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
46.67Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
46.67Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
46.67Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
46.15Single2YDOAdenosine2YDO-A2A-Adenosine
46.15Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
46.15Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
46.15Single4MBSMaraviroc4MBS-CCR5-Maraviroc
46.15Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
46.15Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
46.15Single4ZJCSB-6740424ZJC-OX1-SB-674042
46.15Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
46.15Single6TPNHTL66416TPN-OX2-HTL6641
46.15Single6VI4JDTic6VI4-κ-JDTic
46.15Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
46.15Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
46.15Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
46.15Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
46.15Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
46.15Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
46.15Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
46.15Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
46.15Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
46.15Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
46.15Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
46.15Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
46.15Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
46.15Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
46.15Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
46.15Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
45.45Single3UZAGTPL92363UZA-A2A-GTPL9236
45.45Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
45.45Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
45.45Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
45.45Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
45.45Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
45.45Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
45.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
44.44Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
44.44Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
44.44Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
43.75Single6A93Risperidone6A93-5-HT2A-Risperidone
43.75Single6CM4Risperidone6CM4-D2-Risperidone
43.75Single7DFPSpiperone7DFP-D2-Spiperone
43.75Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
43.75Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
43.75Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
43.75Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
43.75Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
43.75Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
43.75Consensusgs_steroidOrthosteric Ligandgs_bileacid
42.86Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
42.86Single4DAJTiotropium4DAJ-M3-Tiotropium
42.86Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
42.86Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
42.86Single4MQSIperoxo4MQS-M2-Iperoxo
42.86Single4U14Tiotropium4U14-M3-Tiotropium
42.86Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
42.86Single5DSGTiotropium5DSG-M4-Tiotropium
42.86Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
42.86Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
42.86Single6DRXLisuride6DRX-5-HT2B-Lisuride
42.86Single6TOTLemborexant6TOT-OX1-Lemborexant
42.86Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.86Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
42.86Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
42.86Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
42.86Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
42.86Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
42.86Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
42.86Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
42.86Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
42.86Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
42.86Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
42.86Single8X63Mepyramine8X63-H1-Mepyramine
42.86Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
42.86Consensusadenosine_onOrthosteric Liganda1_on a2_on
42.86Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
42.86Consensusgi_hcarOrthosteric Ligandgi_hca
42.86Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
42.86Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
42.86Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
42.86Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
42.86Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
42.86Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
42.86Consensusnucleotide_onOrthosteric Ligandadenosine_on
42.11Single3QAKUK-4320973QAK-A2A-UK-432097
42.11Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
42.11Single6HLOAprepitant6HLO-NK1-Aprepitant
42.11Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
41.67Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
41.67Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
41.67Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
41.67Single6HLLCP999946HLL-NK1-CP99994
41.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
41.67Single7SRQLSD7SRQ-5-HT2B-LSD
41.67Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.67Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.67Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
41.67Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
41.67Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
41.67Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
41.67Single8K5BNiacin8K5B-HCA2-Niacin
41.67Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
41.67Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
41.18Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
41.18Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
41.18Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
41.18Single7EZCUKA7EZC-A2A-UKA
41.18Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
41.18Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
41.18Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
41.18Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
41.18Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
41.18Consensussteroid_onOrthosteric Ligandbileacid_on
40.00Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
40.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
40.00Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
40.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
40.00Single5WF5UK-4320975WF5-A2A-UK-432097
40.00Single5XPRBosentan5XPR-ETB-Bosentan
40.00Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
40.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
40.00Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
40.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
40.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
40.00Single6PT2KGCHM076PT2-δ-KGCHM07
40.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
40.00Single6TP6Filorexant6TP6-OX1-Filorexant
40.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
40.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
40.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
40.00Single8EA0Iperoxo8EA0-M3-Iperoxo
40.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
40.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
40.00Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
40.00Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
40.00Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
40.00Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
38.89Single5WF6UK-4320975WF6-A2A-UK-432097
38.89Single7XN9L-054,5227XN9-SST2-L-054,522
38.89Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
38.89Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
38.89Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
38.46Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
38.46Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
38.46Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
38.46Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
38.46Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
38.46Single5DHHSB-6121115DHH-NOP-SB-612111
38.46Single5WS3EMPA5WS3-OX2-EMPA
38.46Single6B73PubChem 1319551386B73-κ-PubChem 131955138
38.46Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
38.46Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
38.46Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
38.46Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
38.46Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.46Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
38.46Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
38.46Consensusgt_class-aOrthosteric Ligandgt_opsin
38.46Consensusgt_opsinOrthosteric Ligandgt_sensory
38.46Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
38.46Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
38.46Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
38.46Consensusorexin_offOrthosteric Ligandox2_off ox1_off
37.50Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
37.50Single4DJHJDTic4DJH-κ-JDTic
37.50Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
37.50Single6J20Aprepitant6J20-NK1-Aprepitant
37.50Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
37.50Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
37.50Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
37.50Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
37.50Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
37.50Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
37.50Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
37.50Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
37.50Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
37.50Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
37.50Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
37.50Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
37.50Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
36.84Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
36.84Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.84Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
36.84Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
36.84Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
36.36Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
36.36Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
35.71Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
35.71Single3RZECidoxepin3RZE-H1-Cidoxepin
35.71Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
35.71Single6DS0Ly2660976DS0-5-HT2B-Ly266097
35.71Single6IQLL7458706IQL-D4-L745870
35.71Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
35.71Single6V9SGTPL114036V9S-OX1-GTPL11403
35.71Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
35.71Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
35.71Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
35.71Single7T32ZM2413857T32-A2A-ZM241385
35.71Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
35.71Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
35.71Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
35.71Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
35.71Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
35.71Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
35.71Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
35.71Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
35.71Single8K5CAcipimox8K5C-HCA2-Acipimox
35.71Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
35.71Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
35.71Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
35.71Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
35.71Consensushca_onOrthosteric Ligandhca2_on hca3_on
35.71Consensushcar_onOrthosteric Ligandhca_on
35.71Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
35.71Consensussensory_offOrthosteric Ligandopsin_off
35.29Single6HLPNetupitant6HLP-NK1-Netupitant
35.29Single6ZG4HTL00099366ZG4-M1-HTL0009936
35.29Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
35.29Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
35.29Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.29Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
35.29Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
35.29Single8JWZAB9288JWZ-A2A-AB928-Na
35.29Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single8WU1KCA8WU1-CB1-KCA-Arrestin1
35.29Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
35.29Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.29Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
35.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
35.00Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
34.78Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
33.33Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
33.33Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
33.33Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
33.33Single4YAYZD-71554YAY-AT1-ZD-7155
33.33Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
33.33Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
33.33Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
33.33Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
33.33Single6ME5Agomelatine6ME5-MT1-Agomelatine
33.33Single6ME9Ramelteon6ME9-MT2-Ramelteon
33.33Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
33.33Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
33.33Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
33.33Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
33.33Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
33.33Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
33.33Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
33.33Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
33.33Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
33.33Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
33.33Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
33.33Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
33.33Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
33.33Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
33.33Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
33.33Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
33.33Single8CU6LJ-45178CU6-A2A-LJ-4517
33.33Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
33.33Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
33.33Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
33.33Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
33.33Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
33.33Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
33.33Single8K5DGSK2560738K5D-HCA2-GSK256073
33.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
33.33Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusangiotensin_onOrthosteric Ligandat1_on
33.33Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
33.33Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
33.33Consensusblt_onOrthosteric Ligandblt1_on
33.33Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
33.33Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
33.33Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusleuko_onOrthosteric Ligandblt_on
33.33Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
33.33Consensusorexin_onOrthosteric Ligandox2_on
33.33Consensustachykinin_offOrthosteric Ligandnk1_off
32.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
31.82Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
31.82Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
31.82Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
31.82Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
31.82Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
31.82Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
31.58Single5ZTYAM102575ZTY-CB2-AM10257
31.58Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
31.58Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
31.58Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
31.58Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
31.58Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
31.58Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
31.58Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.25Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
31.25Single5CGCHTL142425CGC-mGlu5-HTL14242
31.25Single5NM2ZM2413855NM2-A2A-ZM241385-Na
31.25Single6D26Fevipiprant6D26-DP2-Fevipiprant
31.25Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
31.25Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
31.25Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
31.25Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
31.25Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
31.25Single7SINNPS-21437SIN-CaS-NPS-2143
31.25Single7SINNPS-21437SIN-CaS-NPS-2143
31.25Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
31.25Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
31.25Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
31.25Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
31.25Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
31.25Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
31.25Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
30.77Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
30.77Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
30.77Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
30.77Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
30.77Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
30.77Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
30.77Single6TP4ACT-4622066TP4-OX1-ACT-462206
30.77Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
30.77Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
30.77Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
30.77Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
30.77Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
30.77Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
30.77Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
30.77Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
30.43Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
30.00Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
30.00Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
30.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
30.00Single7F8XNN90567F8X-CCKA-NN9056
30.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
30.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
30.00Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
30.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
30.00Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
30.00Consensussst_onOrthosteric Ligandsst2_on sst4_on
29.41Single5XR8AM8415XR8-CB1-AM841
29.41Single6E59L-7607356E59-NK1-L-760735
29.41Single7EPENAM5637EPE-mGlu-NAM563
29.41Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
29.41Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
29.41Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
29.41Single7TUYGSK682753A7TUY-GPR183-GSK682753A
29.41Single7W41PD1762527W41-BB2-PD176252
29.41Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
29.41Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
29.41Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
29.41Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
29.41Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
29.41Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
29.41Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
29.41Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
29.41Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
29.41Consensusadenosine_offOrthosteric Liganda1_off a2_off
29.41Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
29.41Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
29.41Consensusbombesin_offOrthosteric Ligandbb2_off
29.41Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
29.41Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
29.41Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
29.41Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
29.17Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
29.17Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
28.57Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
28.57Single4S0VSuvorexant4S0V-OX2-Suvorexant
28.57Single5K2DZM2413855K2D-A2A-ZM241385
28.57Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
28.57Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
28.57Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
28.57Single6JZHZM2413856JZH-A2A-ZM241385-Na
28.57Single6PS7ZM2413856PS7-A2A-ZM241385-Na
28.57Single6TPJSuvorexant6TPJ-OX2-Suvorexant
28.57Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
28.57Single7F8ULintitript7F8U-CCKA-Lintitript
28.57Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
28.57Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
28.57Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
28.57Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
28.57Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
28.57Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
28.57Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
28.57Single7XRRLemborexant7XRR-OX2-Lemborexant
28.57Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
28.57Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
28.57Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
28.57Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
28.57Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
28.57Single8GNGIstradefylline8GNG-A2A-Istradefylline
28.57Single8IHKAcifran8IHK-HCA3-Acifran
28.57Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
28.57Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
28.57Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
28.57Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
28.57Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
28.57Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
28.00Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
27.78Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
27.78Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
27.78Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
27.78Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
27.78Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
27.78Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
27.78Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
27.78Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
27.78Single7K15MKD0467K15-BLT1-MKD046-Na
27.78Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
27.78Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
27.78Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
27.78Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
27.78Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
27.78Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
27.78Consensusblt_offOrthosteric Ligandblt1_off
27.78Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
27.78Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
27.78Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
27.78Consensusdp_offOrthosteric Liganddp2_off
27.78Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
27.78Consensusgi_class-fOther Ligandgi_frizzled
27.78Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
27.78Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
27.78Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
27.78Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
27.78Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
27.78Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
27.78Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
27.27Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
27.27Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
27.27Single7WC4Serotonin7WC4-5-HT2A-Serotonin
27.27Single8PWNTheophylline8PWN-A2A-Theophylline
27.27Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
26.92Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
26.92Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
26.67Single3REYPubChem 56973REY-A2A-PubChem 5697
26.67Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
26.67Single5IU4ZM2413855IU4-A2A-ZM241385-Na
26.67Single5IU7Q274563465IU7-A2A-Q27456346-Na
26.67Single5IUBQ274563445IUB-A2A-Q27456344-Na
26.67Single5JTBZM2413855JTB-A2A-ZM241385
26.67Single5K2BZM2413855K2B-A2A-ZM241385-Na
26.67Single5K2CZM2413855K2C-A2A-ZM241385-Na
26.67Single5NLXZM2413855NLX-A2A-ZM241385-Na
26.67Single5NM4ZM2413855NM4-A2A-ZM241385-Na
26.67Single6AQFZM2413856AQF-A2A-ZM241385
26.67Single6TP3Nemorexant6TP3-OX1-Nemorexant
26.67Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
26.67Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
26.67Single6ZG9GSK10347026ZG9-M1-GSK1034702
26.67Single7AROLUF58337ARO-A2A-LUF5833-Na
26.67Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
26.67Single7VODCariprazine7VOD-5-HT2A-Cariprazine
26.67Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
26.67Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
26.67Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
26.67Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
26.67Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
26.67Consensuss1p_offOrthosteric Ligands1p1_off
26.32Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.32Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
26.32Single5CGDHTL142425CGD-mGlu5-HTL14242
26.32Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
26.32Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
26.32Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
26.32Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
26.32Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
26.32Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
26.09Single6JODAngiotensin II6JOD-AT2-Angiotensin II
26.09Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
26.09Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
26.09Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
25.00Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
25.00Single3EMLZM2413853EML-A2A-ZM241385
25.00Single3RFMCaffeine3RFM-A2A-Caffeine
25.00Single4EIYZM2413854EIY-A2A-ZM241385-Na
25.00Single5EE7MK08935EE7-Glucagon-MK0893
25.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
25.00Single5K2AZM2413855K2A-A2A-ZM241385-Na
25.00Single5OLGZM2413855OLG-A2A-ZM241385-Na
25.00Single5TGZAM65385TGZ-CB1-AM6538
25.00Single5UENDU1725UEN-A1-DU172
25.00Single5VRAZM2413855VRA-A2A-ZM241385-Na
25.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
25.00Single6D27CAY104716D27-DP2-CAY10471
25.00Single6GPSMK08126GPS-CCR2-MK0812
25.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
25.00Single6LPJZM2413856LPJ-A2A-ZM241385-Na
25.00Single6LPKZM2413856LPK-A2A-ZM241385-Na
25.00Single6S0LZM2413856S0L-A2A-ZM241385
25.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
25.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
25.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
25.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
25.00Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
25.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
25.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
25.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
25.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
25.00Single7PYRPSB-21157PYR-A2A-PSB-2115
25.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
25.00Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
25.00Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
25.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
25.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
25.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
25.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
25.00Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
25.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
25.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
25.00Consensusa2_offOrthosteric Liganda2a_off
25.00Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
25.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
25.00Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
25.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
25.00Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
25.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
25.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
25.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
25.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
24.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
24.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
23.81Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Single7QA8Peptide7QA8-STE2-Peptide
23.81Single7QA8Peptide7QA8-STE2-Peptide
23.81Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
23.81Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
23.81Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
23.81Consensusclass-d_offOrthosteric Ligandste2_off
23.81Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
23.81Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
23.81Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
23.81Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
23.53Single5IUAQ274563485IUA-A2A-Q27456348-Na
23.53Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
23.53Single5N2SPSB365N2S-A1-PSB36
23.53Single6GPXMK08126GPX-CCR2-MK0812
23.53Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
23.53Single6LPLZM2413856LPL-A2A-ZM241385-Na
23.53Single6S0QZM2413856S0Q-A2A-ZM241385
23.53Single6WQAZM2413856WQA-A2A-ZM241385-Na
23.53Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
23.53Single7C4SS1P7C4S-S1P3-S1P
23.53Single7RM5ZM2413857RM5-A2A-ZM241385-Na
23.53Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
23.53Single8FYNZM2413858FYN-A2A-ZM241385-Na
23.53Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
23.53Single8GNEKW-63568GNE-A2A-KW-6356-Na
23.53Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
23.53Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
23.53Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
23.53Single8QOTNanobody E8QOT-μ-Nanobody E
23.53Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
23.53Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
23.08Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
23.08Single7WC5Psilocin7WC5-5-HT2A-Psilocin
23.08Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
23.08Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
23.08Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
23.08Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
23.08Consensusendothelin_onOrthosteric Ligandetb_on eta_on
23.08Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
23.08Consensusgo_class-b1Orthosteric Ligandgo_crf
23.08Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
22.73Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
22.73Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
22.73Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
22.73Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
22.73Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
22.22Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
22.22Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
22.22Single5XRAAM115425XRA-CB1-AM11542
22.22Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
22.22Single6IGLIRL16206IGL-ETB-IRL1620
22.22Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
22.22Single7PX4PSB-21137PX4-A2A-PSB-2113
22.22Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
22.22Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
22.22Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
22.22Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
22.22Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
22.22Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
22.22Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
22.22Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
22.22Consensuscck_onOrthosteric Ligandccka_on cckb_on
22.22Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
22.22Consensuschemerin_onOrthosteric Ligandcml1_on
22.22Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
22.22Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
22.22Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
22.22Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
22.22Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
22.22Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.22Consensuslpa_offOrthosteric Ligandlpa1_off
22.22Consensuslpa_onOrthosteric Ligandlpa1_on
22.22Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
22.22Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
22.22Consensusrelaxin_onOrthosteric Ligandrxfp4_on
21.74Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
21.74Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
21.74Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
21.74Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
21.74Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
21.74Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
21.74Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
21.74Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
21.43Single3OE9IT1t3OE9-CXCR4-IT1t
21.43Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
21.43Single5GLHEndothelin-15GLH-ETB-Endothelin-1
21.43Single6IGKEndothelin-36IGK-ETB-Endothelin-3
21.43Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
21.43Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
21.43Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
21.43Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
21.43Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
21.43Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
21.05Single4N4WSANT-14N4W-SMO-SANT-1
21.05Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
21.05Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
21.05Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
21.05Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
21.05Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
21.05Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
21.05Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
20.83Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
20.83Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.83Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.83Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
20.83Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
20.83Consensusclass-d_onOrthosteric Ligandste2_on
20.83Consensusgi_class-dOrthosteric Ligandgi_ste
20.83Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.69Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
20.69Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
20.00Single3PWHZM2413853PWH-A2A-ZM241385
20.00Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
20.00Single6K1QIRL25006K1Q-ETB-IRL2500
20.00Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
20.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
20.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
20.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
20.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
20.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
20.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
20.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
20.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
20.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
20.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
20.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
20.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
20.00Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
20.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
20.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
20.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
20.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
20.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
20.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
20.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
20.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
20.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
20.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
20.00Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
20.00Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
20.00Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
20.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
20.00Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
20.00Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusmglu_onOther Ligandmglu2_on mglu4_on
20.00Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
19.35Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
19.35Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
19.35Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
19.23Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
19.23Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
19.23Consensusclass-d_onOrthosteric Ligandste2_on
19.23Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
19.23Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
19.23Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
19.23Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
19.05Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
19.05Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
19.05Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
19.05Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusclass-d_offOrthosteric Ligandste2_off
19.05Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
19.05Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
19.05Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
19.05Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
18.75Single5UVIZM2413855UVI-A2A-ZM241385
18.75Single6FFIMMPEP6FFI-mGlu5-MMPEP
18.75Single6MH8ZM2413856MH8-A2A-ZM241385
18.75Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
18.75Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
18.75Single6TPKRetosiban6TPK-OT-Retosiban
18.75Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
18.75Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
18.75Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.75Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
18.75Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
18.75Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
18.75Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
18.75Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
18.75Consensuspth_onOrthosteric Ligandpth1_on pth2_on
18.75Consensusvasopressin-ot_offOrthosteric Ligandot_off
18.52Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
18.52Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
18.52Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.52Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
18.52Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
18.52Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
18.52Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
18.52Consensusgi_class-dOrthosteric Ligandgi_ste
18.52Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
18.52Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.52Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
18.18Single4XT1Fractalkine4XT1-US28-Fractalkine
18.18Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
18.18Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
18.18Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
18.18Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
18.18Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
17.86Single6LMLGlucagon6LML-Glucagon-Glucagon
17.86Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
17.86Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
17.86Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
17.86Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
17.86Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
17.65Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
17.65Single6FFHFenobam6FFH-mGlu5-Fenobam
17.65Single6IIVDaltroban6IIV-TP-Daltroban
17.65Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
17.65Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
17.65Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
17.65Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
17.65Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
17.65Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
17.65Consensuscck_offOrthosteric Ligandccka_off
17.65Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
17.65Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
17.65Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
17.65Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
17.65Consensushcar_offOrthosteric Ligandsuccinate_off
17.65Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
17.65Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
17.65Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
17.65Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
17.65Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
17.65Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
17.39Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
17.39Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
17.39Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
17.39Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
17.39Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
17.39Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
17.39Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
17.24Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
17.24Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
17.24Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.67Single3OE0CVX153OE0-CXCR4-CVX15
16.67Single4NTJAZD12834NTJ-P2Y12-AZD1283
16.67Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
16.67Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
16.67Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
16.67Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
16.67Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
16.67Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
16.67Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
16.67Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
16.67Single6W25SHU91196W25-MC4-SHU9119-Ca
16.67Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
16.67Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
16.67Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.67Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
16.67Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Single7YXAONO-54306087YXA-S1P5-ONO-5430608
16.67Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
16.67Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
16.67Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
16.67Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
16.67Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
16.67Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
16.67Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
16.67Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
16.67Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
16.67Consensusep_offOrthosteric Ligandep4_off
16.67Consensusglp_onOrthosteric Ligandglp1_on glp2_on
16.67Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
16.22Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
16.13Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
16.13Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
16.13Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
16.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
16.00Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
16.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
16.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
16.00Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
16.00Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
15.79Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
15.79Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
15.79Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
15.79Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
15.79Single7P2L4YI7P2L-mGlu5-4YI
15.79Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
15.79Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
15.79Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
15.79Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.79Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
15.79Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
15.79Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
15.79Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
15.79Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
15.62Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
15.62Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
15.62Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
15.62Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.62Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
15.62Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
15.38Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
15.38Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
15.38Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
15.38Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
15.38Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
15.38Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
15.38Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
15.38Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.15Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
15.00Single5X33BIIL2605X33-BLT1-BIIL260
15.00Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
15.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
15.00Single6IIURamatroban6IIU-TP-Ramatroban
15.00Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
15.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
15.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
15.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
15.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
15.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
15.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
15.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
15.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
15.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
15.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
15.00Consensusclass-b2_onOrthosteric Ligandadgrg_on
15.00Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
15.00Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
14.81Single4XT3Fractalkine4XT3-US28-Fractalkine
14.81Single6FJ3PTH6FJ3-PTH1-PTH
14.81Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
14.81Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
14.81Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
14.81Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
14.81Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
14.81Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
14.81Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
14.29Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
14.29Single3OE6IT1t3OE6-CXCR4-IT1t
14.29Single3OE8IT1t3OE8-CXCR4-IT1t
14.29Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
14.29Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
14.29Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
14.29Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
14.29Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
14.29Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
14.29Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
14.29Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
14.29Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
14.29Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
14.29Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
14.29Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
14.29Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.89Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
13.79Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.79Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
13.79Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
13.79Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single8IY6Endothelin-18IY6-ETB-Endothelin-1
13.79Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.79Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
13.64Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
13.64Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
13.64Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
13.64Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
13.64Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
13.51Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
13.33Single5L7IVismodegib5L7I-SMO-Vismodegib
13.33Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
13.33Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
13.33Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
13.33Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.33Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
13.33Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
13.33Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Consensusclass-t_onOrthosteric Ligandtaste2_on
13.33Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
13.33Consensusgo_class-b2Orthosteric Ligandgo_adhesion
13.33Consensusgs_class-tOrthosteric Ligandgs_taste
13.33Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.33Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.16Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
13.04Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
13.04Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
13.04Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
13.04Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
13.04Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
13.04Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
12.50Single3ODUIT1t3ODU-CXCR4-IT1t
12.50Single5U09Taranabant5U09-CB1-Taranabant
12.50Single5ZKQABT-4915ZKQ-PAF-ABT-491
12.50Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
12.50Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
12.50Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
12.50Single7BR3Elagolix7BR3-GnRH1-Elagolix
12.50Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
12.50Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.50Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.50Single7SK5CXCL127SK5-ACKR3-CXCL12
12.50Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
12.50Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
12.50Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.50Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
12.50Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
12.50Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
12.50Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
12.50Consensussst_offOrthosteric Ligandsst2_off
12.12Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
12.00Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
12.00Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
12.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
12.00Single7XNACYN1548067XNA-SST2-CYN154806
12.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
12.00Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
12.00Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
11.76Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
11.76Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
11.76Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
11.76Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
11.76Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
11.76Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.76Single8K2WAMG4878K2W-CXCR3-AMG487
11.76Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
11.76Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
11.76Consensusgnrh_offOrthosteric Ligandgnrh1_off
11.76Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
11.54Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.54Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.54Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
11.54Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
11.54Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
11.54Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
11.54Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
11.11Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
11.11Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
11.11Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
11.11Single7F83PF-051904577F83-Ghrelin-PF-05190457
11.11Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
11.11Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
11.11Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
11.11Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.11Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.11Consensusclass-c_offOther Ligandgabab_off mglu_off
11.11Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
11.11Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
11.11Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.81Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
10.71Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
10.71Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.71Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
10.71Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
10.71Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
10.71Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.71Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
10.53Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
10.53Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.53Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
10.34Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
10.34Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
10.34Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
10.00Single5TZR-5TZR-FFA1 (GPR40)-MK8666
10.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
10.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
10.00Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
10.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
10.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
10.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
10.00Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
10.00Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
10.00Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
10.00Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
9.68Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.68Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
9.68Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single4PY02MeSATP4PY0-P2Y12-2MeSATP
9.52Single6OS2TRV0266OS2-AT1-TRV026
9.52Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
9.52Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
9.52Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
9.52Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
9.52Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
9.52Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
9.52Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
9.38Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
9.38Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
9.09Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
9.09Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
9.09Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
9.09Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
9.09Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
9.09Consensuscyslt_offOrthosteric Ligandcyslt2_off
9.09Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.82Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
8.70Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
8.70Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
8.70Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
8.70Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
8.70Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
8.70Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
8.70Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
8.70Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Consensusgs_class-b2Orthosteric Ligandgs_adgr
8.70Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
8.33Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
8.33Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.33Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
8.33Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
8.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
8.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
8.00Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
8.00Single7SHEPI; PE7SHE-GPR158-PI; PE
8.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
7.69Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
7.69Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.69Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
7.69Consensusclass-c_onOther Ligandgabab_on mglu_on
7.69Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
7.41Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
7.41Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.41Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
7.14Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
7.14Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
6.90Single7SK3CXCL127SK3-ACKR3-CXCL12
6.90Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
6.67Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.67Single6LI0GTPL98046LI0-GPR52-GTPL9804
6.67Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
6.67Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
6.67Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
6.67Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
6.45Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
6.45Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
6.25Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
6.25Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
6.25Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
6.25Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
6.25Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.88Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.88Single7F8YDevazepide7F8Y-CCKA-Devazepide
5.88Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
5.88Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
5.88Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
5.88Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
5.88Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.88Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.88Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
5.88Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.56Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
5.56Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
5.56Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
5.56Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
5.56Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
5.56Single8IYXYL-3658IYX-GPR34-YL-365
5.56Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.56Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.56Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
5.56Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
5.41Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
5.26Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
5.26Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.26Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.26Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
5.26Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.26Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
5.00Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
5.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
5.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
5.00Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
5.00Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
5.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.76Single5V56TC1145V56-SMO-TC114
4.76Single5V57TC1145V57-SMO-TC114
4.76Single6OS1TRV0266OS1-AT1-TRV026
4.76Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
4.76Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
4.76Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.55Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
4.55Single4XEENeurotensin4XEE-NTS1-Neurotensin
4.55Single4XESNeurotensin4XES-NTS1-Neurotensin
4.55Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.55Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
4.55Single7SHEPI; PE7SHE-GPR158-PI; PE
4.55Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
4.55Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Consensuschemokine_offOrthosteric Ligandcxcr_off
4.55Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
4.55Consensuscxcr_offOrthosteric Ligandcxcr4_off
4.55Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
4.55Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
4.55Consensusnts_offOrthosteric Ligandnts1_off
4.35Single4BUONeurotensin4BUO-NTS1-Neurotensin
4.35Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
4.35Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
4.35Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.35Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single6KNMJN241-96KNM-Apelin-JN241-9
4.17Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
4.00Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
3.85Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.70Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.12Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
3.03Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
3.03Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
3.03Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.94Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.86Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.86Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.78Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.78Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.63Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.50Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.44Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.44Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.33Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 8GGX
Class A
SubFamily Amine
Type Adrenergic
SubType Beta2
Species Homo sapiens
Ligand Epinephrine
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.6
Date 2024-03-06
D.O.I. 10.1038/s41586-024-07153-1
Net Summary
Imin 2.59
Number of Linked Nodes 250
Number of Links 269
Number of Hubs 31
Number of Links mediated by Hubs 122
Number of Communities 10
Number of Nodes involved in Communities 50
Number of Links involved in Communities 63
Path Summary
Number Of Nodes in MetaPath 87
Number Of Links MetaPath 86
Number of Shortest Paths 32111
Length Of Smallest Path 3
Average Path Length 14.1365
Length of Longest Path 37
Minimum Path Strength 1.265
Average Path Strength 5.02543
Maximum Path Strength 20.165
Minimum Path Correlation 0.7
Average Path Correlation 0.933378
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 2.94118
Average % Of Corr. Nodes 56.793
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 35.8401
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeG1I
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeG1I
Name(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
Synonyms
Identifier(5~{R},6~{R})-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
FormulaC11 H15 N O3
Molecular Weight209.242
SMILESCN[C@@H]1CCc2c(ccc(c2O)O)[C@H]1O
PubChem12353638
Formal Charge0
Total Atoms30
Total Chiral Atoms2
Total Bonds31
Total Aromatic Bonds6

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP07550
Sequence
>8GGX_Chain_R
VWVVGMGIV MSLIVLAIV FGNVLVITA IAKFERLQT VTNYFITSL 
ACADLVMGL AVVPFGAAH ILTKTWTFG NFWCEFWTS IDVLCVTAS 
IETLCVIAV DRYFAITSP FKYQSLLTK NKARVIILM VWIVSGLTS 
FLPIQMHWY RATHQEAIN CYAEETCCD FFTNQAYAI ASSIVSFYV 
PLVIMVFVY SRVFQEAKR QLQKIDKSE GRHKALKTL GIIMGTFTL 
CWLPFFIVN IVHVIQDNL IRKEVYILL NWIGYVNSG FNPLIYCRS 
PDFRIAFQE LL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2R4RAAmineAdrenergicβ2Homo sapiens---3.42007-11-0610.1038/nature06325
2R4SAAmineAdrenergicβ2Homo sapiens---3.42007-11-0610.1038/nature06325
2RH1AAmineAdrenergicβ2Homo sapiens(S)-Carazolol--2.42007-10-3010.1126/science.1150577
3D4SAAmineAdrenergicβ2Homo sapiensTimolol Maleate--2.82008-06-1710.1016/j.str.2008.05.001
3KJ6AAmineAdrenergicβ2Homo sapiens---3.42010-02-1610.1038/nature08650
3NY8AAmineAdrenergicβ2Homo sapiensICI 118-551--2.842010-08-1110.1021/ja105108q
3NY9AAmineAdrenergicβ2Homo sapiensPubChem 913103--2.842010-08-1110.1021/ja105108q
3NYAAAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--3.162010-08-1110.1021/ja105108q
3P0GAAmineAdrenergicβ2Homo sapiensBI167107--3.52011-01-1910.1038/nature09648
3PDSAAmineAdrenergicβ2Homo sapiensHydroxybenzylisoproterenol--3.52011-01-1210.1038/nature09665
3SN6AAmineAdrenergicβ2Homo sapiensBI167107-Gs/&β;1/&γ;23.22011-07-2010.1038/nature10361
4GBRAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.992012-10-2410.1371/journal.pone.0046039
4LDEAAmineAdrenergicβ2Homo sapiensBI167107--2.792013-09-2510.1038/nature12572
4LDLAAmineAdrenergicβ2Homo sapiensHydroxybenzylisoproterenol--3.12013-09-2510.1038/nature12572
4LDOAAmineAdrenergicβ2Homo sapiensL-Epinephrine--3.22013-09-2510.1038/nature12572
4QKXAAmineAdrenergicβ2Homo sapiensPubChem 76210628--3.32014-07-2310.1073/pnas.1410415111
5D5AAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--2.482016-01-1310.1107/S2059798315021683
5D5BAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.82016-01-1310.1107/S2059798315021683
5D6LAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.22016-08-1710.1038/nprot.2017.057
5JQHAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.22016-07-1310.1038/nature18636
5X7DAAmineAdrenergicβ2Homo sapiens(S)-CarazololPubChem 129318963-2.72017-08-1610.1038/nature23652
6E67AAmineAdrenergicβ2Homo sapiensBI167107-Gs (fused)3.72019-06-0510.1016/j.cell.2019.04.021
6MXTAAmineAdrenergicβ2Homo sapiensSalmeterol--2.962018-11-1410.1038/s41589-018-0145-x
6N48AAmineAdrenergicβ2Homo sapiensBI167107PubChem 138454256-3.22019-06-2610.1126/science.aaw8981
6NI3AAmineAdrenergicβ2Homo sapiensBI167107-Gs/&β;1/&γ;23.82019-11-2010.1038/s41594-019-0330-y
6OBAAAmineAdrenergicβ2Homo sapiens(S)-AlprenololGTPL11074-3.12020-03-2510.1038/s41589-020-0549-2
6PRZAAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--2.82019-11-1310.1107/S2052252519013137
6PS0AAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.42019-11-1310.1107/S2052252519013137
6PS1AAmineAdrenergicβ2Homo sapiensTimolol--3.22019-11-1310.1107/S2052252519013137
6PS2AAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--2.42019-11-1310.1107/S2052252519013137
6PS3AAmineAdrenergicβ2Homo sapiens(S)-Carvedilol--2.52019-11-1310.1107/S2052252519013137
6PS4AAmineAdrenergicβ2Homo sapiensICI 118-551--2.62019-11-1310.1107/S2052252519013137
6PS5AAmineAdrenergicβ2Homo sapiens(S)-Propranolol--2.92019-11-1310.1107/S2052252519013137
6PS6AAmineAdrenergicβ2Homo sapiensTimolol--2.72019-11-1310.1107/S2052252519013137
7BZ2AAmineAdrenergicβ2Homo sapiensArformoterol-Gs/&β;1/&γ;23.822020-08-0510.1038/s41421-020-0176-9
7DHIAAmineAdrenergicβ2Homo sapiensSalbutamol-Gs/&β;1/&γ;23.262020-12-1610.1093/nsr/nwaa284
7DHRAAmineAdrenergicβ2Homo sapiensIsoprenaline-Gs/&β;1/&γ;23.82020-12-1610.1093/nsr/nwaa284
7XKAAAmineAdrenergicβ2Homo sapiensEpinephrine--3.12023-04-2610.1038/s41467-023-37808-y
8GDZAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GE1AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE3AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GE4AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GE6AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE7AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE8AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE9AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEAAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEBAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8GECAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEDAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEEAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.72024-03-0610.1038/s41586-024-07153-1
8GEFAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8GEGAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8GEHAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;242024-03-0610.1038/s41586-024-07153-1
8GEIAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;24.12024-03-0610.1038/s41586-024-07153-1
8GEJAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;24.22024-03-0610.1038/s41586-024-07153-1
8GFVAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.12024-03-0610.1038/s41586-024-07153-1
8GFWAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFXAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFYAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFZAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG0AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;22.92024-03-0610.1038/s41586-024-07153-1
8GG1AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG2AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG3AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.12024-03-0610.1038/s41586-024-07153-1
8GG4AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.22024-03-0610.1038/s41586-024-07153-1
8GG5AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.22024-03-0610.1038/s41586-024-07153-1
8GG6AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG7AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG8AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG9AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GGAAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGBAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGCAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GGEAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGFAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8GGIAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGJAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGKAAmineAdrenergicβ2Homo sapiensEpinephrine--3.32024-03-0610.1038/s41586-024-07153-1
8GGLAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGMAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGNAAmineAdrenergicβ2Homo sapiensEpinephrine--3.32024-03-0610.1038/s41586-024-07153-1
8GGOAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGPAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGQAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGRAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGSAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGTAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGUAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGVAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGWAAmineAdrenergicβ2Homo sapiensEpinephrine--3.62024-03-0610.1038/s41586-024-07153-1
8GGYAAmineAdrenergicβ2Homo sapiensEpinephrine--3.92024-03-0610.1038/s41586-024-07153-1
8GGZAAmineAdrenergicβ2Homo sapiensEpinephrine--3.92024-03-0610.1038/s41586-024-07153-1
8GH0AAmineAdrenergicβ2Homo sapiensEpinephrine--42024-03-0610.1038/s41586-024-07153-1
8GH1AAmineAdrenergicβ2Homo sapiensEpinephrine--4.12024-03-0610.1038/s41586-024-07153-1
8JJ8AAmineAdrenergicβ2Homo sapiensFormoterol--3.22023-09-0610.1038/s41589-023-01389-0
8JJLAAmineAdrenergicβ2Homo sapiensOlodaterol--3.22023-09-0610.1038/s41589-023-01389-0
8JJOAAmineAdrenergicβ2Homo sapiensAlprenolol--3.42023-09-0610.1038/s41589-023-01389-0
8UNLAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNMAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNNAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNOAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNPAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNQAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNRAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNSAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNTAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNUAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UNVAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNWAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNXAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UNYAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UNZAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8UO0AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UO1AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UO2AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UO3AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UO4AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;242024-03-0610.1038/s41586-024-07153-1




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