Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.H1.01 4.026675189
2G.S2.02 1.99541405
3G.S2.03 5.048115129
4G.S2.06 4.63422409
5G.S3.01 3.85948475
6G.S3.03 5.40035678
7G.S3.04 9.706634127
8G.S3.06 8.239035127
9G.H2.01 4.99471419
10G.H2.05 5.47319418
11G.H2.06 5.30628619
12G.H2.07 5.22468619
13G.h2s4.01 8.9425409
14G.S4.07 5.46303408
15G.s4h3.04 5.046585208
16G.H3.01 1.99815809
17G.H3.08 2.64822408
18G.H3.09 4.811075199
19G.H3.13 7.808836196
20G.H3.17 8.01076615
21G.S5.05 4.21364669
22G.S5.07 3.1893509
23G.HG.01 5.3189456
24G.hgh4.04 2.08507406
25G.hgh4.05 11.0846406
26G.hgh4.11 3.93504405
27G.hgh4.20 5.44211403
28G.H4.03 3.15847404
29G.H4.08 5.26171553
30G.H4.10 8.31219507
31G.H4.12 6.07224554
32G.H4.13 3.35403503
33G.H4.15 6.98071408
34G.h4s6.12 4.74073402
35G.h4s6.20 4.70685594
36G.S6.02 6.52945598
37G.S6.05 6.92484555
38G.H5.03 4.74204469
39G.H5.06 6.14004464
40G.H5.08 4.96644678
41G.H5.13 4.34651498
42G.H5.17 7.50676595
43G.H5.20 3.48558408
44G.H5.23 5.57325404
45b.1x3 0.817924401
46b.1x4 1.92431408
47b.lhb1x3 3.07893502
48b.lhb1x6 3.697795133
49b.l1x3 9.13913539
50b.l1x6 9.32754519
51b.b2x1 6.29678518
52b.b2x5 5.69637637
53b.l3x1 7.72111419
54b.l3x2 5.719915179
55b.b4x6 8.53272739
56b.b4x7 7.19826408
57b.b5x2 6.07086407
58b.b5x3 5.39438639
59b.b5x5 4.8416405
60b.b5x7 5.11173407
61b.l5x1 4.356525218
62b.l5x5 8.63568509
63b.b6x1 4.63357419
64b.b6x5 3.86127506
65b.l6x5 5.87274144
66b.b7x1 5.74254144
67b.b8x4 5.77382406
68b.l8x5 2.81111403
69b.l9x3 7.68657519
70b.l9x6 5.21772718
71b.b10x5 4.156509
72b.l10x1 3.86572403
73b.b11x2 4.13583407
74b.l11x2 8.37801419
75b.b12x6 7.95737718
76b.b13x7 7.42033547
77b.l13x3 7.34399649
78b.l13x6 5.24659519
79b.l13x7 4.21415549
80b.b15x1 5.99679549
81b.l15x1 5.53926417
82b.l15x2 5.53574449
83b.b16x4 10.3475446
84b.b16x5 4.5751405
85b.b16x6 7.3712748
86b.b17x5 6.5666417
87b.b17x7 7.79726418
88b.l17x3 8.53259619
89b.l17x6 6.79588519
90b.b18x3 4.80388418
91b.b18x5 4.45627405
92b.l18x1 6.489366156
93b.l18x2 5.540374157
94b.b19x2 6.90348516
95b.b19x4 5.42181418
96b.l19x2 5.8436519
97b.b20x4 9.89412518
98b.b20x6 6.86427516
99b.b20x7 4.40452409
100b.l20x2 5.90551509
101b.b21x1 8.96116417
102b.b21x5 4.92784404
103b.b21x7 5.54656605
104b.l21x2 4.51556404
105b.b22x5 5.646745157
106b.l22x5 6.526295139
107b.b23x6 6.782546167
108b.l23x1 6.36658416
109b.b24x4 6.998774166
110b.b24x6 5.965724168
111b.l24x3 5.18733405
112b.l25x3 7.979715109
113b.l25x6 11.2938518
114b.b26x3 3.43311406
115b.l27x1 9.43281719
116b.l27x2 7.890154109
117b.b28x3 3.93322537
118b.b28x4 7.156774106
119b.b28x6 8.459045109
120g.l1x4 5.07143408
121g.ctx3 5.29715609
122g.ctx6 3.090956136
123g.ctx14 5.49419489
124g.ctx15 5.5781489
125g.ctx16 4.46278888
126Lig 5.555012120
1271x39 5.81656527
1281x46 3.4255408
1291x50 6.07104409
130I1x50 4.14394118
1312x40 3.866335119
1322x42 3.86256608
1332x46 4.5355429
1342x50 6.67072529
1352x57 4.19395427
136E1x50 3.825276248
1373x37 4.13661407
1383x43 4.49481428
1393x49 5.359394239
1403x50 5.31036429
141I2x51 4.74454477
1424x38 2.39012408
143E2 9.050611423
1445x39 5.83666428
1455x44 4.576407
1465x58 4.56615629
1475x62 2.25199506
1486x30 2.34124508
1496x44 4.68356529
1506x48 6.65675628
1516x51 4.74642527
1526x52 7.11691527
1536x60 2.51473405
154E3 4.98655923
1557x42 4.80714427
1567x49 6.579429
1577x53 4.90954529
1588x48 3.28775406
1598x50 3.630576119
1608x54 1.7131407
161E1 0.242731400
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b4x7 b.l2x5 29.013614.5748YesNo085
2b.l2x5 b.l4x2 53.284421.1068NoNo054
3b.l4x2 g.ctx15 44.23659.69938NoYes849
4b.l26x5 g.ctx15 49.73513.92716NoYes059
5b.l26x5 g.ctx4 50.79784.99657NoNo057
6g.ctx3 g.ctx4 51.07573.91678YesNo097
7g.ctx3 g.ctx5 50.58323.20244YesNo099
8b.lhb1x11 g.ctx5 50.79544.34627NoNo049
9b.b25x7 b.lhb1x11 51.00834.64385NoNo074
10b.b24x3 b.b25x7 17.09033.81522NoNo057
11b.b24x3 b.l25x7 17.17513.68798NoNo057
12b.l25x3 b.l25x7 17.26452.92729YesNo097
13b.l25x3 b.l27x2 99.92097.90906YesYes1099
14b.l25x4 b.l27x2 1004.58266NoYes059
15I1x49 b.l25x4 99.81234.57442NoNo065
161x60 I1x49 99.78392.43466NoNo066
171x60 I1x50 99.15415.32089NoYes1168
182x40 I1x50 97.47663.79193YesYes1198
192x39 2x40 98.48712.84309NoYes089
202x39 3x49 98.44595.08557NoYes089
213x49 I2x53 47.59125.57038YesNo2398
223x53 I2x53 47.61915.66379NoNo088
233x53 G.H5.19 66.93144.43208NoNo088
24G.H5.15 G.H5.19 66.6863.89119NoNo088
25G.H5.15 I2x50 66.56323.56345NoNo088
26G.H5.12 I2x50 30.52154.03933NoNo078
27G.H5.12 I2x51 30.38343.76512NoYes077
28b.b25x7 b.b28x6 34.307216.2449NoYes079
29b.b27x3 b.b28x6 17.65518.12813NoYes089
30b.b27x3 b.l25x3 66.01916.8979NoYes089
31b.b26x2 b.b2x3 14.35675.32748NoNo076
32b.b26x1 b.b26x2 14.4492.97503NoNo097
33b.b26x1 b.l27x1 14.54415.25876NoYes099
34b.l25x6 b.l27x1 46.729719.4747YesYes189
35b.b22x1 b.l25x6 48.89135.70841NoYes088
36b.b22x1 b.b22x2 48.92.96369NoNo088
37b.b22x2 b.b26x3 48.93474.45084NoYes086
38b.b26x3 b.b27x3 49.5073.02202YesNo068
39b.b28x4 b.b28x6 17.42527.02413YesYes1069
40b.b28x4 b.l25x3 17.48079.00635YesYes1069
41G.S3.01 I2x51 10.32614.7832YesYes757
42G.H5.08 I2x51 10.34254.84592YesYes787
43G.S1.04 G.S3.03 24.44863.09834NoYes078
44G.S1.04 G.S4.03 23.99873.24218NoNo077
45G.H1.01 G.s1h1.05 14.29493.46907YesNo099
46G.S4.05 G.s1h1.05 15.35984.00504NoNo079
47G.S4.05 G.S5.07 17.48923.05529NoYes079
48G.S5.07 G.s6h5.01 50.56284.58939YesNo099
49G.S5.05 G.s6h5.01 51.60156.88257YesNo699
50G.S4.03 G.S5.05 23.09383.23735NoYes679
51G.S5.03 G.S5.05 15.36093.54584NoYes099
52G.H5.10 G.S5.03 15.9579.80959NoNo079
53G.H5.10 G.S6.02 33.420910.0373NoYes078
54G.H5.13 G.S6.02 17.13895.26206YesYes988
555x68 G.H5.13 17.57433.88027NoYes978
565x68 G.H5.16 35.70965.92707NoNo076
57G.H5.16 I2x50 35.98684.74427NoNo068
58G.S5.05 G.S6.04 15.36034.49508YesNo099
59G.H5.10 G.S6.04 17.170910.076NoNo079
60G.H5.17 G.S6.02 17.12957.49262YesYes958
615x68 G.H5.17 17.99697.50485NoYes975
62b.b2x1 b.l27x1 51.56565.38278YesYes189
63b.b2x1 b.b6x1 48.26155.66939YesYes189
64b.b6x1 b.l9x6 48.18085.80995YesYes198
65G.H2.07 b.l9x6 24.78313.26882YesYes198
66G.H2.06 b.l9x6 26.61043.99116YesYes198
67G.H2.04 G.H2.07 25.21146.78523NoYes099
68G.H2.04 G.H3.08 25.10036.06568NoYes098
69G.H2.06 b.l17x6 26.08027.28301YesYes199
70G.H3.08 G.S4.04 24.79683.93748YesNo089
71G.S4.04 G.S4.06 11.51143.85343NoNo097
72G.H3.09 G.S4.04 13.18125.08191YesNo099
73G.H4.15 G.S4.06 11.28065.75065YesNo087
74G.H3.09 G.H4.15 11.36125.63638YesYes098
75G.S5.07 G.s5hg.01 27.82034.50533YesNo099
76G.S4.07 G.s5hg.01 20.37248.93417YesNo089
77G.H4.10 G.H4.14 11.01787.92963YesNo075
78G.H3.06 G.H4.14 11.70813.65423NoNo065
79G.H3.06 G.H4.15 12.43469.11555NoYes068
803x53 G.H5.23 21.17813.18558NoYes084
812x42 3x46 44.20992.9252YesNo089
822x42 3x49 52.42237.53665YesYes089
83b.l17x5 b.l17x6 26.67643.38801NoYes169
84b.l17x5 b.l19x2 26.59942.57073NoYes169
85b.l17x3 b.l19x2 17.95234.22238YesYes199
86b.b17x7 b.b20x6 22.13919.37999YesYes186
87b.b17x5 b.b17x7 17.85978.12928YesYes178
88b.b16x5 b.b17x5 17.18623.64132YesYes057
89b.b16x5 b.b17x4 15.7433.17219YesNo055
90b.b17x4 b.l16x3 15.0213.61247NoNo2253
91b.b17x2 b.l16x3 14.66655.85869NoNo033
92b.b17x2 g.h1x13 14.30641.82939NoNo031
93g.h1x13 g.h1x9 13.94632.14683NoNo016
94g.h1x12 g.h1x9 13.22562.56607NoNo066
95b.1x11 g.h1x12 12.50442.06605NoNo086
96b.b20x4 b.b20x6 15.46853.95523YesYes186
97b.l21x7 b.l23x1 12.3543.64496NoYes056
98b.l21x7 b.l23x2 12.00436.47046NoNo058
99b.b23x6 b.l23x2 11.2993.90617YesNo078
100b.b3x1 b.b4x7 25.24432.93092NoYes058
101b.b3x1 b.b6x5 48.55214.05068NoYes056
102b.b2x4 b.b6x5 28.6732.60055NoYes066
103b.b10x4 b.b2x4 28.173412.793NoNo066
104b.l4x1 g.ctx16 10.115.85372NoYes058
105b.b2x5 b.l4x1 10.01384.99994YesNo075
106b.l2x3 b.l2x5 24.06753.83465NoNo085
107b.b3x1 b.l2x3 23.82455.25348NoNo058
108b.b3x3 b.b6x5 18.65854.54903NoYes086
109b.b3x3 b.b6x3 18.15643.43187NoNo088
110b.b3x5 b.b6x3 17.1523.13936NoNo098
111b.b3x5 b.l5x6 16.64962.90349NoNo099
112b.l5x1 b.l5x6 16.1474.18981YesNo089
113b.b10x2 b.b10x4 20.1274.18772NoNo066
114b.b10x2 b.b14x3 19.62654.50497NoNo065
115b.b14x3 b.b15x1 10.57343.22562NoYes059
1163x46 7x53 41.11374.72629NoYes299
1173x43 7x53 51.70025.88793YesYes289
1183x43 6x44 39.4692.94744YesYes289
1196x44 6x48 46.96298.14533YesYes298
1203x36 6x48 19.09144.41362NoYes278
1213x36 Lig 18.94546.8083NoYes270
1226x48 6x52 24.60074.17867YesYes287
1236x52 Lig 19.03994.39046YesYes270
1241x39 7x42 14.58594.78333YesYes277
1252x50 7x46 10.59078.18389YesNo099
1262x46 2x50 10.6014.39504YesYes299
1277x38 7x42 12.03155.14773NoYes267
1283x50 5x58 12.15344.20768YesYes299
129b.b2x3 b.b2x5 10.61133.73098NoYes367
1303x50 G.H5.23 20.51129.53162YesYes094
1313x50 7x53 11.39434.39457YesYes299
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
E2Lig4.955472YesYes3010
E2x51Lig5.504332NoYes4010
E3Lig4.015092YesYes3010
6x55Lig7.309012NoYes7010
7x34Lig5.569562NoYes5010
2x60Lig3.257112NoYes7010
3x29Lig3.087442NoYes6010
3x32Lig6.971252NoYes7010
4x61Lig2.909172NoYes7010
E2x52Lig13.56782NoYes5010
5x40Lig5.471552NoYes6010
3x33Lig5.188582NoYes6010
3x36Lig6.80832NoYes7010
5x43Lig4.546922NoYes7010
6x52Lig4.390462YesYes7010
2x563x324.919220NoNo7721
2x567x423.557650NoYes7722
E1x49E23.365170NoYes4321
3x22E29.427412NoYes4321
3x26E25.321012NoYes5321
3x294x653.468892NoNo6612
3x334x573.427642NoNo6812
3x366x484.413622NoYes7812
4x64E24.02650NoYes5321
E2E233.8652YesYes3311
E2E2x5111.12392YesNo3411
E2E2x525.890662YesNo3511
5x36E26.052892NoYes5321
5x39E26.267152YesYes8321
5x395x435.380312YesNo8721
5x406x552.984032NoNo6711
5x446x528.374680YesYes7721
5x476x5213.62220NoYes8721
6x486x524.178672YesYes8721
6x487x415.969972YesNo8722
6x516x525.018532YesYes7711
6x516x555.240632YesNo7711
6x517x383.058612YesNo7611
6x517x413.326852YesNo7712
6x576x613.003522NoNo5422
6x57E36.626832NoYes5321
6x58E35.276470NoYes4321
6x61E37.454642NoYes4321
E3E38.675792YesYes3311
7x387x425.147732NoYes6712
7x38Lig6.790172NoYes6010
6x51Lig7.087462YesYes7010
3x264x612.932912NoNo5721
3x304x613.866440NoNo6721
6x547x344.144950NoNo5521
7x30E32.557992NoYes0321
5x406x592.320772NoNo6612
2x603x282.221912NoNo7612
4x63E21.628360NoYes5321
7x33E31.550010NoYes4321
2x67NT1.323332NoNo4312
2x67Lig1.020092NoYes4010
5x35E20.4822222NoYes4321
5x34E20.4377780NoYes2321
2x672x680.1527592NoNo4012
3x18Lig0.1026850NoYes0010
6x62E30.0463030NoYes0321

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
65.22Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
65.22Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
64.29Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
63.64Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
62.50Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
62.50Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
60.87Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
60.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
60.00Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
59.09Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
58.33Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
57.69Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
57.14Single4RWADIPP-NH24RWA-δ-DIPP-NH2
57.14Single7YITNalfurafine7YIT-κ-Nalfurafine
57.14Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
56.52Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
56.52Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
55.56Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
55.56Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
55.56Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
55.56Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
55.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
55.00Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
55.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
54.55Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
54.55Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
54.55Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
54.55Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
54.17Single3QAKUK-4320973QAK-A2A-UK-432097
54.17Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
54.17Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
53.85Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
52.63Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
52.38Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
52.38Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
52.38Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
52.38Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
52.38Single8E0GBU728E0G-μ-BU72
52.38Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
52.38Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
52.38Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
52.38Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
52.38Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
52.38Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
52.38Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
52.17Single3NY9ICI118-5513NY9-β2-ICI118-551
52.17Single4UG2CGS216804UG2-A2A-CGS21680
52.17Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
52.17Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
52.17Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
52.17Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
52.17Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
52.00Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
52.00Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
52.00Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
52.00Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
51.85Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
51.85Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
51.85Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
51.85Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
50.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
50.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
50.00Single6MXTSalmeterol6MXT-β2-Salmeterol
50.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
50.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
50.00Single7F8XNN90567F8X-CCKA-NN9056
50.00Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
50.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
50.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
50.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
50.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
50.00Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
50.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
50.00Single8JJLOlodaterol8JJL-β2-Olodaterol
50.00Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8WDTphotoNECA8WDT-A2A-photoNECA
50.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
50.00Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
50.00Single9CHXS-Carazolol9CHX-β2-S-Carazolol
50.00Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
50.00Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
50.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
50.00Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
50.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
50.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
50.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
50.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
50.00Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
50.00Consensusorexin_onOrthosteric Ligandox2_on
48.28Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
48.15Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
48.15Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
48.15Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
48.15Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
48.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
48.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
48.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
48.00Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
48.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
47.83Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
47.83Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
47.83Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
47.83Single7EZCUKA7EZC-A2A-UKA
47.83Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
47.83Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
47.83Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
47.83Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
47.83Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
47.83Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
47.83Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
47.83Consensuscck_onOrthosteric Ligandccka_on cckb_on
47.83Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
47.83Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
47.83Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
47.83Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
47.62Single5C1MBU725C1M-μ-BU72
47.62Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
47.62Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
47.62Single5WQCEMPA5WQC-OX2-EMPA
47.62Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
47.62Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
47.62Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
47.62Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
47.62Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
47.62Single7C61Ergotamine7C61-5-HT1B-Ergotamine
47.62Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
47.62Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
47.62Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
47.62Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
47.62Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
47.62Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
47.62Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
47.62Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
47.62Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
47.62Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
47.62Single8JXSPF-61428JXS-D1-PF-6142
47.62Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
47.62Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
47.62Consensusadenosine_offOrthosteric Liganda1_off a2_off
47.62Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
47.62Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
47.62Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
47.37Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
47.37Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
47.37Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
47.37Consensusorexin_offOrthosteric Ligandox2_off ox1_off
47.37Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
46.67Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
46.67Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
46.67Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
46.43Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
46.15Single5WF5UK-4320975WF5-A2A-UK-432097
46.15Single6PT2KGCHM076PT2-δ-KGCHM07
46.15Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
46.15Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
46.15Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
45.83Single5WF6UK-4320975WF6-A2A-UK-432097
45.83Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
45.83Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
45.83Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
45.83Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
45.83Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
45.83Single8QJ2pN1628QJ2-MC4-pN162-Gs
45.83Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
45.83Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
45.45Single2YDVNECA2YDV-A2A-NECA
45.45Single3P0GBI1671073P0G-β2-BI167107
45.45Single4UHRCGS216804UHR-A2A-CGS21680
45.45Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
45.45Single5G53NECA5G53-A2A-NECA-Gs
45.45Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
45.45Single6H7JIsoprenaline6H7J-β1-Isoprenaline
45.45Single6J20Aprepitant6J20-NK1-Aprepitant
45.45Single6J21Aprepitant6J21-NK1-Aprepitant
45.45Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
45.45Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
45.45Single6TQ7SB-3348676TQ7-OX1-SB-334867
45.45Single6WGTLSD6WGT-5-HT2A-LSD
45.45Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
45.45Single7PX4PSB-21137PX4-A2A-PSB-2113
45.45Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
45.45Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
45.45Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
45.45Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
45.45Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.45Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
45.45Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
45.45Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
45.45Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
45.45Consensusa2_onOrthosteric Liganda2b_on
45.45Consensusa2_on_gpOrthosteric Liganda2b_on_gp
45.45Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
45.45Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
45.45Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.45Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
45.45Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
45.16Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
45.16Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
45.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
45.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
45.00Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
45.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
45.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
45.00Single5JTBZM-2413855JTB-A2A-ZM-241385
45.00Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
45.00Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
45.00Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
45.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
45.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
45.00Single6PS0S-Carazolol6PS0-β2-S-Carazolol
45.00Single6PS4ICI118-5516PS4-β2-ICI118-551
45.00Single6PS5S-Propranolol6PS5-β2-S-Propranolol
45.00Single6TPGEMPA6TPG-OX2-EMPA
45.00Single6TPNHTL66416TPN-OX2-HTL6641
45.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
45.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
45.00Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
45.00Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
45.00Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
45.00Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
45.00Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
45.00Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
45.00Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
45.00Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
45.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
45.00Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
45.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
45.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
45.00Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
45.00Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
45.00Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
45.00Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
45.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
45.00Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
45.00Consensusa2_offOrthosteric Liganda2a_off
45.00Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
45.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
45.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
44.83Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
44.83Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
44.83Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
44.83Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
44.83Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
44.83Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
44.44Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
44.44Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
44.44Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
44.44Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
44.44Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
44.44Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
44.44Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
44.44Consensusvasop-oxy_onOrthosteric Ligandv2_on
44.44Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
44.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
44.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
44.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
44.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
44.00Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
44.00Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
44.00Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
44.00Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
44.00Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
43.48Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
43.48Single4AMIBucindolol4AMI-β1-Bucindolol
43.48Single4LDEBI1671074LDE-β2-BI167107
43.48Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
43.48Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
43.48Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
43.48Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
43.48Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
43.48Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
43.48Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
43.48Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
43.48Single8JJ8Formoterol8JJ8-β2-Formoterol
43.48Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
43.48Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
43.48Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
43.48Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
43.48Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
43.48Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
43.48Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
43.48Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
43.48Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
43.48Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
43.48Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
43.33Single6IGLIRL16206IGL-ETB-IRL1620
43.33Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
42.86Single2Y02Carmoterol2Y02-β1-Carmoterol
42.86Single2Y04Salbutamol2Y04-β1-Salbutamol
42.86Single3EMLZM-2413853EML-A2A-ZM-241385
42.86Single3NY8ICI118-5513NY8-β2-ICI118-551
42.86Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
42.86Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
42.86Single4GBRS-Carazolol4GBR-β2-S-Carazolol
42.86Single5IU8Q274563475IU8-A2A-Q27456347-Na
42.86Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
42.86Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
42.86Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
42.86Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
42.86Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
42.86Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
42.86Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
42.86Single6PS1Timolol6PS1-β2-Timolol
42.86Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
42.86Single6S0LZM-2413856S0L-A2A-ZM-241385
42.86Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
42.86Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
42.86Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
42.86Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
42.86Single7PYRPSB-21157PYR-A2A-PSB-2115
42.86Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
42.86Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
42.86Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
42.86Single7UL4Alvimopan7UL4-μ-Alvimopan
42.86Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
42.86Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
42.86Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
42.86Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
42.86Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
42.86Single8CU6LJ-45178CU6-A2A-LJ-4517
42.86Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
42.86Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
42.86Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
42.86Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
42.86Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
42.86Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
42.86Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
42.86Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
42.86Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
42.86Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
42.86Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
42.86Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
42.86Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
42.86Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
42.86Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
42.86Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
42.86Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
42.86Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
42.86Consensus5ht5_onOrthosteric Ligand5ht5a_on
42.86Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
42.86Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
42.86Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
42.86Consensusa3_onOrthosteric Liganda3a_on
42.86Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
42.86Consensuscck_offOrthosteric Ligandccka_off
42.86Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
42.86Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
42.86Consensusdopamine_offOrthosteric Ligandd2_off d3_off
42.86Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
42.86Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
42.86Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
42.42Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
42.31Single6HLOAprepitant6HLO-NK1-Aprepitant
42.31Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
42.31Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
42.31Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
42.31Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
42.31Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
42.31Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
42.31Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
42.31Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
42.31Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
42.31Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
42.11Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
42.11Single6HLLCP999946HLL-NK1-CP99994
42.11Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
42.11Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
42.11Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
42.11Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
42.11Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
42.11Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
42.11Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
41.94Single5GLHEndothelin-15GLH-ETB-Endothelin-1
41.94Single6IGKEndothelin-36IGK-ETB-Endothelin-3
41.94Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
41.94Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
41.94Consensusbombesin_onOrthosteric Ligandbb2_on
41.94Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
41.94Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
41.94Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
41.67Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
41.67Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
41.67Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
41.67Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
41.67Single5X93K-87945X93-ETB-K-8794
41.67Single6IBLArformoterol6IBL-β1-Arformoterol
41.67Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
41.67Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
41.67Single7UM4AS26747237UM4-5-HT5A-AS2674723
41.67Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
41.67Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
41.67Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
41.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
41.67Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
41.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
41.67Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.67Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
41.67Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
41.67Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
41.67Consensusendothelin_offOrthosteric Ligandetb_off
41.67Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
41.67Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
41.67Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
41.67Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
41.38Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
41.38Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
41.38Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
41.38Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
41.38Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
41.38Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
40.91Single2RH1S-Carazolol2RH1-β2-S-Carazolol
40.91Single2Y03Isoprenaline2Y03-β1-Isoprenaline
40.91Single2YCWS-Carazolol2YCW-β1-S-Carazolol
40.91Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
40.91Single5D6LS-Carazolol5D6L-β2-S-Carazolol
40.91Single5IUAQ274563485IUA-A2A-Q27456348-Na
40.91Single5JQHS-Carazolol5JQH-β2-S-Carazolol
40.91Single5N2SPSB365N2S-A1-PSB36
40.91Single5TVNLSD5TVN-5-HT2B-LSD
40.91Single6E67BI1671076E67-β2-BI167107-Gs (fused)
40.91Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
40.91Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
40.91Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
40.91Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
40.91Single6S0QZM-2413856S0Q-A2A-ZM-241385
40.91Single6TP6Filorexant6TP6-OX1-Filorexant
40.91Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
40.91Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
40.91Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
40.91Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
40.91Single7W41PD1762527W41-BB2-PD176252
40.91Single7WC6LSD7WC6-5-HT2A-LSD
40.91Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.91Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
40.91Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
40.91Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
40.91Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.91Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.91Single8GNEKW-63568GNE-A2A-KW-6356-Na
40.91Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
40.91Single8QOTNanobody-E8QOT-μ-Nanobody-E
40.91Single8TF5Oleic acid8TF5-GPR6-Oleic acid
40.91Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
40.91Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
40.91Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
40.91Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
40.91Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
40.91Consensusa3_on_gpOrthosteric Liganda3a_on_gp
40.91Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
40.91Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
40.91Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
40.91Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
40.91Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
40.91Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
40.91Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
40.91Consensusamine_offonOrthosteric Ligandamine_off amine_on
40.91Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
40.91Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
40.91Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
40.91Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
40.91Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
40.91Consensusbombesin_offOrthosteric Ligandbb2_off
40.91Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
40.91Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
40.91Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
40.91Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
40.91Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
40.91Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
40.91Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.91Consensustrace-amine_onOrthosteric Ligandta1_on
40.74Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
40.74Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
40.74Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
40.74Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
40.74Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
40.74Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
40.74Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
40.74Consensusangiotensin_onOrthosteric Ligandat1_on
40.74Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
40.74Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
40.74Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
40.00Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
40.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
40.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
40.00Single5WS3EMPA5WS3-OX2-EMPA
40.00Single5ZTYAM102575ZTY-CB2-AM10257
40.00Single6AKXA4R6AKX-CCR5-A4R
40.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
40.00Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
40.00Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
40.00Single6PT3DPI-2876PT3-δ-DPI-287
40.00Single6TODEMPA6TOD-OX1-EMPA-Na
40.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
40.00Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
40.00Single7F8ULintitript7F8U-CCKA-Lintitript
40.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
40.00Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
40.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
40.00Single7XN9L-054,5227XN9-SST2-L-054,522
40.00Single7XRRLemborexant7XRR-OX2-Lemborexant
40.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
40.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
40.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
40.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
40.00Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
40.00Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
40.00Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
40.00Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
40.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
40.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
40.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
40.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
40.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
40.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
40.00Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
40.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
40.00Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
40.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
40.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
40.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
40.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
40.00Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
40.00Consensusalpha2_offOrthosteric Ligandalpha2c_off
40.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
40.00Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
40.00Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
40.00Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
40.00Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
40.00Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
40.00Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
40.00Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
40.00Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
39.39Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
39.29Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
39.29Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
39.29Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
39.29Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
39.29Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
39.29Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
39.29Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
39.29Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
39.29Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
39.29Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
39.29Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
39.29Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
39.29Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
39.13Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
39.13Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
39.13Single5D5AS-Carazolol5D5A-β2-S-Carazolol
39.13Single5D5BS-Carazolol5D5B-β2-S-Carazolol
39.13Single6E59L-7607356E59-NK1-L-760735
39.13Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
39.13Single7B6WCyclazosin7B6W-α1b-Cyclazosin
39.13Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
39.13Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
39.13Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
39.13Single7TUYGSK682753A7TUY-GPR183-GSK682753A
39.13Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
39.13Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
39.13Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
39.13Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
39.13Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
39.13Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
39.13Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
39.13Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
39.13Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
39.13Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
39.13Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
39.13Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
39.13Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
39.13Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
39.13Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
39.13Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
39.13Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
39.13Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
39.13Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
39.13Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
39.13Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
39.13Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
39.13Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
39.13Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
39.13Consensusrelaxin_onOrthosteric Ligandrxfp4_on
39.13Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
39.13Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
39.13Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
39.13Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
39.13Consensustachykinin_offOrthosteric Ligandnk1_off
39.13Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
38.71Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
38.71Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
38.71Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
38.71Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
38.71Consensusbradykinin_onOrthosteric Ligandbk2_on
38.71Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
38.71Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
38.46Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
38.46Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
38.46Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
38.46Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
38.46Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
38.46Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
38.46Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
38.46Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
38.46Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
38.46Single8WKYPG-9348WKY-MC4-PG-934
38.46Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
38.46Consensuslpl_onOrthosteric Ligands1p_on lpa_on
38.46Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
38.46Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
38.10Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
38.10Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
38.10Single4MBSMaraviroc4MBS-CCR5-Maraviroc
38.10Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
38.10Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
38.10Single5UVIZM-2413855UVI-A2A-ZM-241385
38.10Single6AQFZM-2413856AQF-A2A-ZM-241385
38.10Single6KUXRS-799486KUX-α2a-RS-79948
38.10Single6MH8ZM-2413856MH8-A2A-ZM-241385
38.10Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
38.10Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
38.10Single6V9SGTPL114036V9S-OX1-GTPL11403
38.10Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
38.10Single7AROLUF58337ARO-A2A-LUF5833-Na
38.10Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
38.10Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
38.10Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
38.10Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
38.10Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
38.10Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
38.10Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.10Single7T32ZM-2413857T32-A2A-ZM-241385
38.10Single7UL3Famotidine7UL3-H2-Famotidine
38.10Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
38.10Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
38.10Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
38.10Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
38.10Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
38.10Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
38.10Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
38.10Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
38.10Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
38.10Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
38.10Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.10Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.10Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
38.10Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
38.10Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
38.10Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
38.10Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
38.10Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
38.10Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.10Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.10Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.10Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
38.10Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
38.10Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
38.10Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
38.10Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
38.10Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
38.10Consensusalpha1_onOrthosteric Ligandalpha1a_on
38.10Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
38.10Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
38.10Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
38.10Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
38.10Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
38.10Consensushca_onOrthosteric Ligandhca2_on
37.93Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
37.93Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
37.93Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
37.93Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
37.93Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
37.93Single8ZRTET-18ZRT-ETB-ET-1
37.93Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
37.93Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
37.93Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
37.50Single3D4STimolol3D4S-β2-Timolol
37.50Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
37.50Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
37.50Single6A93Risperidone6A93-5-HT2A-Risperidone
37.50Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
37.50Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
37.50Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
37.50Single7DFPSpiperone7DFP-D2-Spiperone
37.50Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
37.50Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
37.50Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
37.50Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
37.50Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
37.50Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
37.50Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
37.50Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
37.50Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
37.50Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
37.50Single8JWY2-1188JWY-A2A-2-118
37.50Single8JWZAB9288JWZ-A2A-AB928-Na
37.50Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
37.50Single8XYIVUF106618XYI-CXCR3-VUF10661
37.50Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
37.50Consensusalpha1_offOrthosteric Ligandalpha1a_off
37.50Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
37.50Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
37.50Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
37.50Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
37.50Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
37.50Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
37.50Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
37.50Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
37.50Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
37.50Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
37.50Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
37.50Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
37.50Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
37.50Consensuslpa_offOrthosteric Ligandlpa1_off
37.50Consensuslpl_offOrthosteric Ligands1p_off lpa_off
37.50Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
37.50Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
37.04Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
37.04Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
37.04Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
37.04Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
37.04Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
37.04Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
37.04Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
37.04Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
36.84Single6ME5Agomelatine6ME5-MT1-Agomelatine
36.84Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.84Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
36.84Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
36.67Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
36.67Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
36.67Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
36.36Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
36.36Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
36.36Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
36.36Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
36.36Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
36.36Single4EJ4Naltrindole4EJ4-δ-Naltrindole
36.36Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
36.36Single5UENDU1725UEN-A1-DU172
36.36Single5UIGCmpd-15UIG-A2A-Cmpd-1
36.36Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
36.36Single6DRXLisuride6DRX-5-HT2B-Lisuride
36.36Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
36.36Single6H7MSalbutamol6H7M-β1-Salbutamol
36.36Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
36.36Single6TOTLemborexant6TOT-OX1-Lemborexant
36.36Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
36.36Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
36.36Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
36.36Single7V3ZCP559407V3Z-CB1-CP55940
36.36Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
36.36Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
36.36Single7WC7Lisuride7WC7-5-HT2A-Lisuride
36.36Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
36.36Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
36.36Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
36.36Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
36.36Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
36.36Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
36.36Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
36.36Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
36.36Single8JJOAlprenolol8JJO-β2-Alprenolol
36.36Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
36.36Single8JXRLSD8JXR-D1-LSD
36.36Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
36.36Single8T1WCVN4248T1W-GPR6-CVN424
36.36Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
36.36Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
36.36Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
36.36Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
36.36Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
36.36Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
36.36Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
36.36Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
36.36Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
36.36Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
36.36Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
36.36Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
36.36Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
36.36Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
36.36Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
36.36Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
36.36Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
36.36Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
36.36Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
36.36Consensushca_on_gpOrthosteric Ligandhca2_on_gp
36.36Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
36.11Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
36.11Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
36.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
36.00Single6H7LDobutamine6H7L-β1-Dobutamine
36.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
36.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
36.00Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
36.00Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
36.00Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
36.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
36.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
36.00Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
36.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
36.00Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
36.00Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
36.00Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
36.00Consensuschemerin_onOrthosteric Ligandcml1_on
36.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
36.00Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Single3OE0CVX153OE0-CXCR4-CVX15
35.71Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
35.71Single6W25SHU91196W25-MC4-SHU9119-Ca
35.71Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
35.71Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
35.71Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
35.48Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
35.00Single3OE9IT1t3OE9-CXCR4-IT1t
35.00Single3PBLEticlopride3PBL-D3-Eticlopride
35.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
35.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
35.00Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
35.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
35.00Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
35.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
35.00Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
35.00Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
35.00Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
35.00Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
35.00Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
35.00Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
35.00Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
35.00Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
35.00Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
34.78Single5N2RPSB-365N2R-A2A-PSB-36-Na
34.78Single5WIUNemonapride5WIU-D4-Nemonapride
34.78Single5WIVNemonapride5WIV-D4-Nemonapride-Na
34.78Single5XPRBosentan5XPR-ETB-Bosentan
34.78Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
34.78Single6D26Fevipiprant6D26-DP2-Fevipiprant
34.78Single6HLPNetupitant6HLP-NK1-Netupitant
34.78Single6PS6Timolol6PS6-β2-Timolol
34.78Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
34.78Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
34.78Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
34.78Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
34.78Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.78Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
34.78Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
34.78Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
34.78Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
34.78Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
34.78Single8S4DCMF-0198S4D-Apelin-CMF-019
34.78Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
34.78Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
34.78Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
34.78Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
34.78Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
34.78Single8ZMFA1L108ZMF-5-HT2C-A1L10
34.78Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
34.78Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
34.78Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
34.78Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
34.78Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
34.78Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
34.78Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
34.78Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
34.78Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
34.78Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
34.78Consensusdp_offOrthosteric Liganddp2_off
34.78Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
34.78Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
34.78Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
34.78Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
34.78Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
34.62Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
34.62Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
34.62Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
34.62Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
34.62Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
34.62Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
34.62Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
34.62Single8X5YAstemizole8X5Y-H1-Astemizole
34.62Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
34.48Single6JODAngiotensin II6JOD-AT2-Angiotensin II
34.48Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
34.48Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
34.48Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
34.48Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
34.48Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
34.48Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
34.48Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
34.48Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
34.38Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
34.38Consensusendothelin_onOrthosteric Ligandetb_on eta_on
34.38Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
33.33Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
33.33Single3PWHZM-2413853PWH-A2A-ZM-241385
33.33Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
33.33Single4DJHJDTic4DJH-κ-JDTic
33.33Single4S0VSuvorexant4S0V-OX2-Suvorexant
33.33Single4XT1Fractalkine4XT1-US28-Fractalkine
33.33Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
33.33Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
33.33Single5TZRMK86665TZR-FFA1-MK8666
33.33Single5V54Methiothepin5V54-5-HT1B-Methiothepin
33.33Single5XR8AM8415XR8-CB1-AM841
33.33Single5XRAAM115425XRA-CB1-AM11542
33.33Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
33.33Single6AKYMaraviroc6AKY-CCR5-Maraviroc
33.33Single6B73MP11046B73-κ-MP1104
33.33Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
33.33Single6ME9Ramelteon6ME9-MT2-Ramelteon
33.33Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
33.33Single6TPJSuvorexant6TPJ-OX2-Suvorexant
33.33Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
33.33Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
33.33Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
33.33Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
33.33Single7F8YDevazepide7F8Y-CCKA-Devazepide
33.33Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7FEECP559407FEE-CB1-CP55940-ZCZ011
33.33Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
33.33Single7QA8Peptide7QA8-STE2-Peptide
33.33Single7QA8Peptide7QA8-STE2-Peptide
33.33Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
33.33Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
33.33Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
33.33Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
33.33Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
33.33Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
33.33Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
33.33Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
33.33Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
33.33Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
33.33Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
33.33Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
33.33Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
33.33Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
33.33Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
33.33Single8IEBA1LYA8IEB-GPR156-A1LYA
33.33Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
33.33Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
33.33Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
33.33Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
33.33Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
33.33Single8IWESpermidine8IWE-TA9-Spermidine
33.33Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
33.33Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
33.33Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
33.33Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
33.33Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
33.33Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
33.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
33.33Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
33.33Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
33.33Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
33.33Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
33.33Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
33.33Single8XVLZibotentan8XVL-ETA-Zibotentan
33.33Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
33.33Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
33.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
33.33Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
33.33Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
33.33Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
33.33Consensus5ht1_offOrthosteric Ligand5ht1b_off
33.33Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
33.33Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
33.33Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
33.33Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
33.33Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
33.33Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
33.33Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
33.33Consensuslpa_onOrthosteric Ligandlpa1_on
33.33Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
33.33Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
33.33Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
33.33Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
32.35Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
32.35Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
32.26Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
32.26Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
32.26Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
32.26Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
32.14Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
32.14Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
32.14Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
32.14Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
32.14Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
32.14Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
32.14Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
32.14Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
32.14Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
32.14Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
32.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
32.00Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
32.00Single6KQICP559406KQI-CB1-CP55940-Org27569
32.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
32.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
32.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
32.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
32.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
32.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
32.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
32.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
32.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
32.00Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
32.00Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
32.00Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
32.00Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
32.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
32.00Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
32.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
32.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
32.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
32.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.00Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.82Single2YDOAdenosine2YDO-A2A-Adenosine
31.82Single3REYXAC3REY-A2A-XAC
31.82Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
31.82Single6A94Zotepine6A94-5-HT2A-Zotepine
31.82Single6IQLL7458706IQL-D4-L745870
31.82Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
31.82Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
31.82Single6TP3Nemorexant6TP3-OX1-Nemorexant
31.82Single6TPKRetosiban6TPK-OT-Retosiban
31.82Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
31.82Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
31.82Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
31.82Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
31.82Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
31.82Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
31.82Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
31.82Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
31.82Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
31.82Single8IHKAcifran8IHK-HCA3-Acifran
31.82Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
31.82Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
31.82Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
31.82Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
31.82Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
31.82Single8K5CAcipimox8K5C-HCA2-Acipimox
31.82Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
31.82Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.82Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
31.82Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
31.82Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
31.82Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
31.82Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single9BJKNaloxone9BJK-μ-Naloxone-NAM
31.82Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
31.82Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
31.82Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
31.82Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
31.82Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
31.82Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
31.82Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
31.82Consensusvasop-oxy_offOrthosteric Ligandot_off
31.58Single3RFMCaffeine3RFM-A2A-Caffeine
31.58Single8A2OTheophylline8A2O-A2A-Theophylline-Na
31.58Single9CHUNoradrenaline9CHU-β2-Noradrenaline
31.58Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
31.58Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
31.25Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
31.25Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
31.03Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
31.03Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.03Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
31.03Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
31.03Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
31.03Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
31.03Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
31.03Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
31.03Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
31.03Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
31.03Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
30.95Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
30.77Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
30.77Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
30.77Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
30.77Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
30.77Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
30.77Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
30.77Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
30.77Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
30.77Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
30.77Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
30.77Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
30.77Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Consensusprostanoid_offOrthosteric Ligandep_off dp_off
30.43Single2Y01Dobutamine2Y01-β1-Dobutamine
30.43Single4QKX35V4QKX-β2-35V
30.43Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
30.43Single4YAYZD-71554YAY-AT1-ZD-7155
30.43Single5DHGC-355DHG-NOP-C-35
30.43Single5DHHSB-6121115DHH-NOP-SB-612111
30.43Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
30.43Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
30.43Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
30.43Single7BU7BI1671077BU7-β1-BI167107
30.43Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
30.43Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
30.43Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
30.43Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
30.43Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
30.43Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.43Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
30.43Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
30.43Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
30.43Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
30.43Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
30.43Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
30.43Single8K5DGSK2560738K5D-HCA2-GSK256073
30.43Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
30.43Single8RLNLUF58348RLN-A2A-LUF5834
30.43Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
30.43Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
30.43Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
30.43Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
30.43Single8X63Mepyramine8X63-H1-Mepyramine
30.43Single8X64Desloratadine8X64-H1-Desloratadine
30.43Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
30.43Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
30.43Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
30.43Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
30.43Single9IYAONO-97105319IYA-GPR55-ONO-9710531
30.43Consensusalpha2_onOrthosteric Ligandalpha2b_on
30.43Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
30.43Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
30.43Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
30.43Consensushistamine_offOrthosteric Ligandh1_off
30.43Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
30.43Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
30.30Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
30.30Single8IY6Endothelin-18IY6-ETB-Endothelin-1
30.00Single3OE6IT1t3OE6-CXCR4-IT1t
30.00Single3UZAGTPL92363UZA-A2A-GTPL9236
30.00Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
30.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
30.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
30.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.00Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
30.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
30.00Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
30.00Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
30.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
30.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.00Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
30.00Consensus5ht2_onOrthosteric Ligand5ht2b_on
30.00Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
30.00Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
30.00Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
30.00Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
30.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
30.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
30.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
30.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
29.63Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
29.63Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
29.63Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
29.63Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
29.63Single7SK9CCX6627SK9-ACKR3-CCX662
29.63Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
29.63Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
29.63Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
29.63Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
29.63Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
29.63Consensuskisspeptin_onOrthosteric Ligandkiss1_on
29.63Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
29.17Single2Y00Dobutamine2Y00-β1-Dobutamine
29.17Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
29.17Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
29.17Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
29.17Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
29.17Single7SINNPS-21437SIN-CaS-NPS-2143
29.17Single7SINNPS-21437SIN-CaS-NPS-2143
29.17Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
29.17Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
29.17Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
29.17Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
29.17Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
29.17Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.17Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
29.17Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
29.17Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
29.17Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
29.17Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
29.17Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
29.17Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
29.17Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
29.17Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
29.03Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
29.03Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
29.03Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
29.03Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
29.03Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
28.57Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
28.57Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
28.57Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
28.57Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
28.57Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
28.57Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
28.57Single7SRQLSD7SRQ-5-HT2B-LSD
28.57Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
28.57Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
28.57Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
28.57Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
28.57Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
28.57Single8IEPA1LYA8IEP-GPR156-A1LYA
28.57Single8IEPA1LYA8IEP-GPR156-A1LYA
28.57Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
28.57Single8K5BNiacin8K5B-HCA2-Niacin
28.57Single8KIGSHU91198KIG-MC3-SHU9119-Ca
28.57Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
28.57Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
28.57Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
28.57Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
28.57Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
28.57Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
28.57Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
28.57Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
28.57Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
28.57Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
28.57Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
28.57Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
28.12Single4XT3Fractalkine4XT3-US28-Fractalkine
28.12Single6FJ3PTH6FJ3-PTH1-PTH
28.12Single7SK3CXCL127SK3-ACKR3-CXCL12
28.12Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
28.12Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
28.00Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
28.00Single4U15Tiotropium4U15-M3-Tiotropium
28.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
28.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
28.00Single6OL9Tiotropium6OL9-M5-Tiotropium
28.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
28.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
28.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
28.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
28.00Single7R0CAVP7R0C-V2-AVP-Arrestin2
28.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
28.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
28.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
28.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
28.00Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
28.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
28.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
28.00Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
28.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
28.00Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
28.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
28.00Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
28.00Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
28.00Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
28.00Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
28.00Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
28.00Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
28.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
28.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
28.00Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
28.00Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
27.59Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
27.59Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
27.59Single7SK5CXCL127SK5-ACKR3-CXCL12
27.59Single7XNACYN1548067XNA-SST2-CYN154806
27.59Single8IEBA1LYA8IEB-GPR156-A1LYA
27.59Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
27.59Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
27.59Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
27.27Single3ODUIT1t3ODU-CXCR4-IT1t
27.27Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
27.27Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
27.27Single5ZKQABT-4915ZKQ-PAF-ABT-491
27.27Single6DS0Ly2660976DS0-5-HT2B-Ly266097
27.27Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
27.27Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
27.27Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
27.27Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
27.27Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
27.27Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
27.27Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
27.27Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
27.27Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
27.27Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
27.27Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
27.27Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
27.27Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
27.27Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
27.27Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
27.27Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
27.27Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
27.27Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
27.27Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
27.27Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
27.27Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
27.27Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
27.27Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
27.27Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
27.27Single8Y0HVUF114188Y0H-CXCR3-VUF11418
27.27Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
27.27Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
27.27Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
27.27Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
27.27Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
27.27Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Consensusangiotensin_offOrthosteric Ligandat1_off
27.27Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
27.27Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
27.27Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
27.27Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
27.27Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
27.27Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
27.27Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
27.27Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
27.27Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
27.03Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
27.03Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
26.92Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.92Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
26.92Single5CXVTiotropium5CXV-M1-Tiotropium
26.92Single6CM4Risperidone6CM4-D2-Risperidone
26.92Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
26.92Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
26.92Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
26.92Single6ZG4HTL00099366ZG4-M1-HTL0009936
26.92Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
26.92Single7K15MKD0467K15-BLT1-MKD046-Na
26.92Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
26.92Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
26.92Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
26.92Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.92Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
26.92Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
26.92Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
26.92Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
26.92Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
26.92Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
26.92Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
26.92Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
26.92Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
26.92Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
26.92Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
26.67Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
26.67Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
26.47Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
26.47Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
26.47Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
26.47Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
26.47Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
26.32Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
26.32Single8PWNTheophylline8PWN-A2A-Theophylline
26.09Single3RZECidoxepin3RZE-H1-Cidoxepin
26.09Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
26.09Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
26.09Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
26.09Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
26.09Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
26.09Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
26.09Single6VI4JDTic6VI4-κ-JDTic
26.09Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
26.09Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
26.09Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
26.09Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
26.09Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
26.09Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
26.09Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
26.09Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.09Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
26.09Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
26.09Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
26.09Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
26.09Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
26.09Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
26.09Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
26.09Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
26.09Consensusgrh_offOrthosteric Ligandgnrh1_off
26.09Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
25.93Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
25.93Single6K1QIRL25006K1Q-ETB-IRL2500
25.93Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
25.93Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
25.93Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
25.93Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.93Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.81Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
25.81Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
25.81Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
25.81Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
25.81Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
25.81Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
25.81Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
25.71Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
25.71Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
25.00Single4DAJTiotropium4DAJ-M3-Tiotropium
25.00Single4MQSIperoxo4MQS-M2-Iperoxo
25.00Single4U14Tiotropium4U14-M3-Tiotropium
25.00Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
25.00Single5EE7MK08935EE7-Glucagon-MK0893
25.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
25.00Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
25.00Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
25.00Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
25.00Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
25.00Single6D27CAY104716D27-DP2-CAY10471
25.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
25.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
25.00Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
25.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
25.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
25.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
25.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
25.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
25.00Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
25.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
25.00Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
25.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
25.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
25.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
25.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
25.00Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
25.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
25.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
25.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
25.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
25.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
25.00Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8IEIA1LYA8IEI-GPR156-A1LYA
25.00Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
25.00Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
25.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
25.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
25.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
25.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
25.00Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
25.00Consensusblt_onOrthosteric Ligandblt1_on
25.00Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
25.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
25.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
25.00Consensusleukotriene_onOrthosteric Ligandblt_on
25.00Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
24.32Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
24.24Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
24.24Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
24.24Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
24.24Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
24.24Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
24.14Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
24.14Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
24.14Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.14Single8IEIA1LYA8IEI-GPR156-A1LYA
24.14Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
24.14Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
24.14Consensussomatostatin_offOrthosteric Ligandsst2_off
24.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
24.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
24.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
24.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
24.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
24.00Single7C4SS1P7C4S-S1P3-S1P
24.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
24.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
24.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
24.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
24.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
24.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
24.00Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
24.00Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
24.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
24.00Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
24.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
23.81Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
23.81Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
23.81Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
23.81Single7WC5Psilocin7WC5-5-HT2A-Psilocin
23.81Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.81Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
23.81Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
23.81Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
23.81Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
23.81Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
23.81Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
23.68Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.53Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
23.53Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
23.53Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
23.53Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
23.33Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
23.33Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
23.33Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
23.08Single5V56TC1145V56-SMO-TC114
23.08Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
23.08Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
23.08Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
23.08Single8EA0Iperoxo8EA0-M3-Iperoxo
23.08Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
23.08Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
23.08Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
23.08Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
23.08Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
22.86Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
22.86Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
22.86Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
22.86Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
22.86Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
22.86Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
22.73Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
22.73Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
22.73Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
22.73Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
22.73Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
22.73Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
22.73Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
22.73Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
22.73Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
22.73Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
22.73Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
22.73Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
22.73Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.73Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
22.73Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
22.73Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
22.73Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
22.73Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
22.73Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
22.58Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
22.58Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
22.58Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
22.22Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
22.22Single4N4WSANT-14N4W-SMO-SANT-1
22.22Single4PY02MeSATP4PY0-P2Y12-2MeSATP
22.22Single4XEENeurotensin4XEE-NTS1-Neurotensin
22.22Single4XESNeurotensin4XES-NTS1-Neurotensin
22.22Single6OS2TRV0266OS2-AT1-TRV026
22.22Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
22.22Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
22.22Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
22.22Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
22.22Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
22.22Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
22.22Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
22.22Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
21.88Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
21.88Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
21.88Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
21.88Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
21.88Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
21.74Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
21.74Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
21.74Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
21.74Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
21.74Single7BR3Elagolix7BR3-GnRH1-Elagolix
21.74Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
21.74Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
21.74Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
21.74Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
21.74Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
21.74Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
21.74Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
21.74Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
21.74Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
21.74Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
21.74Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
21.74Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
21.74Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
21.74Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
21.74Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
21.74Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
21.74Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
21.74Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
21.74Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
21.74Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
21.43Single4BUONeurotensin4BUO-NTS1-Neurotensin
21.43Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
21.43Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
21.43Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
21.43Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
21.43Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
21.43Single8XVJMacitentan8XVJ-ETA-Macitentan
21.43Single8XVUCXCL28XVU-CXCR2-CXCL2
21.43Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
21.43Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
21.21Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
21.21Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
21.05Single5MZPCaffeine5MZP-A2A-Caffeine-Na
21.05Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
21.05Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
21.05Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
21.05Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.83Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
20.83Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
20.83Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
20.83Single6ZG9GSK10347026ZG9-M1-GSK1034702
20.83Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
20.83Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
20.83Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
20.83Single7VODCariprazine7VOD-5-HT2A-Cariprazine
20.83Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.83Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
20.83Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
20.83Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
20.83Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
20.83Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
20.83Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
20.83Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
20.83Consensusopsins_offOrthosteric Ligandrhodopsin_off
20.83Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.83Consensussensory_offOrthosteric Ligandopsins_off
20.69Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
20.69Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
20.69Single8XQJJN2418XQJ-Apelin-JN241
20.69Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
20.69Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
20.59Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
20.59Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
20.59Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
20.59Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
20.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
20.00Single4QIMANTA XV4QIM-SMO-ANTA XV
20.00Single5DSGTiotropium5DSG-M4-Tiotropium
20.00Single5TGZAM65385TGZ-CB1-AM6538
20.00Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
20.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
20.00Single6GPSMK08126GPS-CCR2-MK0812
20.00Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
20.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
20.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
20.00Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
20.00Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
20.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
20.00Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
20.00Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
20.00Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
20.00Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
20.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
20.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
20.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
20.00Single8XWNCXCL88XWN-CXCR2-CXCL8
20.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.00Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
20.00Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
20.00Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
20.00Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
20.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
20.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
20.00Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
20.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
19.44Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
19.44Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
19.44Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
19.35Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
19.23Single4JKVTaladegib4JKV-SMO-Taladegib
19.23Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
19.23Single6GPXMK08126GPX-CCR2-MK0812
19.23Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
19.23Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
19.23Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
19.23Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
19.23Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
19.23Consensusblt_offOrthosteric Ligandblt1_off
19.23Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
19.23Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
19.23Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
19.05Single3OE8IT1t3OE8-CXCR4-IT1t
19.05Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
19.05Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
19.05Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
19.05Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
19.05Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
19.05Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
19.05Consensussensory_onOrthosteric Ligandopsins_on
18.92Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
18.75Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
18.52Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
18.52Single4BV0Neurotensin4BV0-NTS1-Neurotensin
18.52Single5V57TC1145V57-SMO-TC114
18.52Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.52Single6OS1TRV0266OS1-AT1-TRV026
18.52Single7F1TMIP-1a7F1T-CCR5-MIP-1a
18.52Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
18.52Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
18.52Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
18.52Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
18.52Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
18.52Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
18.52Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.52Consensusneurotensin_onOrthosteric Ligandnts1_on
18.52Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
18.52Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
18.42Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
18.42Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
18.18Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
18.18Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
18.18Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
18.18Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
18.18Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
18.18Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
18.18Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
18.18Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
18.18Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
18.18Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
18.18Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
18.18Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
18.18Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
18.18Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
18.18Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
18.18Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
18.18Consensusgi_sensoryOrthosteric Ligandgi_opsins
18.18Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
18.18Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
18.18Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
18.18Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
18.18Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
17.95Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
17.95Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
17.86Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
17.86Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
17.86Single6YVRNTS8-136YVR-NTS1-NTS8-13
17.86Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
17.86Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.86Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
17.86Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
17.86Single8XWACXCL18XWA-CXCR2-CXCL1
17.86Single8XWMCXCL68XWM-CXCR2-CXCL6
17.86Single8XWSCXCL58XWS-CXCR2-CXCL5
17.86Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.86Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.65Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
17.65Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
17.39Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
17.39Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
17.39Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
17.39Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
17.39Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
17.39Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
17.39Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
17.39Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
17.39Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
17.39Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
17.39Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
17.39Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
17.39Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single9B9Y7DY9B9Y-CB1-7DY
17.39Consensusgq_nucleotideOrthosteric Ligandgq_p2y
17.39Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
17.39Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
17.24Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
17.24Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
17.24Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
17.24Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8XWFCXCL38XWF-CXCR2-CXCL3
17.24Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
17.24Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
17.24Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
17.14Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
16.67Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
16.67Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
16.67Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
16.67Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
16.67Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
16.67Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
16.67Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
16.67Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
16.67Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
16.67Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
16.67Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
16.67Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
16.67Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
16.67Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
16.67Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
16.22Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
16.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
16.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
16.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.00Single7VV6C48/807VV6-MRGPRX2-C48/80
16.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
16.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
16.00Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8K2WAMG4878K2W-CXCR3-AMG487
16.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
16.00Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
15.91Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
15.79Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
15.79Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
15.56Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
15.38Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
15.38Single7F83PF-051904577F83-Ghrelin-PF-05190457
15.38Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
15.38Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
15.38Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
15.38Single7YXAONO-54306087YXA-S1P5-ONO-5430608
15.38Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
15.38Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
15.38Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
15.00Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
14.81Single5CGCHTL142425CGC-mGlu5-HTL14242
14.81Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
14.81Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
14.81Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
14.81Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
14.81Single6Z4SSR486926Z4S-NTS1-SR48692
14.81Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.81Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
14.81Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
14.81Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
14.81Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
14.81Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
14.81Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
14.81Consensusep_offOrthosteric Ligandep4_off
14.71Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
14.71Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
14.71Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
14.63Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
14.63Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
14.63Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
14.29Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
14.29Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
14.29Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
14.29Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
14.29Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
14.29Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
14.29Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
14.29Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
14.29Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
14.29Single9BJKNAM9BJK-μ-Naloxone-NAM
13.79Single5X33BIIL2605X33-BLT1-BIIL260
13.79Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
13.79Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8XQJJN2418XQJ-Apelin-JN241
13.79Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.79Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
13.51Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
13.51Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
13.33Single5CGDHTL142425CGD-mGlu5-HTL14242
13.33Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
13.33Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
13.33Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
13.33Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
13.16Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
13.16Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
13.04Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
13.04Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
13.04Single4XNWMRS25004XNW-P2Y1-MRS2500
13.04Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
13.04Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
13.04Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
12.90Single6KNMJN241-96KNM-Apelin-JN241-9
12.90Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
12.90Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
12.50Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
12.50Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
12.50Single5L7IVismodegib5L7I-SMO-Vismodegib
12.50Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
12.50Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
12.50Single7UL2SR486927UL2-NTS1-SR48692-Na
12.50Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.50Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
12.50Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
12.50Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
12.50Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.50Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.50Consensusneurotensin_offOrthosteric Ligandnts1_off
12.50Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
12.12Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
12.12Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
12.12Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
12.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
12.00Single5U09Taranabant5U09-CB1-Taranabant
12.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
12.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
12.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
12.00Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
12.00Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
12.00Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
12.00Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
12.00Single9BA0A1AKN9BA0-CB1-A1AKN
12.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
12.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.90Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
11.54Single6ZINSR486926ZIN-NTS1-SR48692
11.54Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
11.43Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
11.11Single5T04Neurotensin5T04-NTS1-Neurotensin
11.11Single6IIVDaltroban6IIV-TP-Daltroban
11.11Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
11.11Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
11.11Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
11.11Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
11.11Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
11.11Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
11.11Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
11.11Single9B9ZA1AKO9B9Z-CB1-A1AKO
11.11Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
10.71Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
10.71Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
10.71Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
10.71Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
10.71Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
10.71Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
10.34Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
10.34Single7P2L4YI7P2L-mGlu5-4YI
10.34Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
10.00Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
10.00Single6IIURamatroban6IIU-TP-Ramatroban
10.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
9.68Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
9.52Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
9.52Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
9.52Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
9.09Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
9.09Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
9.09Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
9.09Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
9.09Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
8.70Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
8.70Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
8.70Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
8.70Consensusp2y_offOrthosteric Ligandp2y1_off
8.33Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
8.33Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
8.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
8.00Single6LI0C176LI0-GPR52-C17
7.69Single4QINSAG1.54QIN-SMO-SAG1.5
7.69Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
7.69Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
7.69Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
7.69Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
7.41Single6FFIMMPEP6FFI-mGlu5-MMPEP
7.41Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
7.41Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
7.41Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
7.14Single6FFHFenobam6FFH-mGlu5-Fenobam
6.90Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
6.67Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
6.67Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
6.25Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
6.06Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
5.88Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
5.71Single7SHEPI; PE7SHE-GPR158-PI; PE
4.76Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.55Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
4.35Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.35Single9GE2Cholesterol9GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
4.17Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
4.17Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
4.00Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
4.00Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
4.00Single8JPSCCL78JPS-ACKR1-CCL7
4.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
3.85Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
3.85Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.85Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
3.85Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.70Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
3.70Single8G94CD698G94-S1P1-CD69-Gi1/β1/γ2
3.57Single8IYXYL-3658IYX-GPR34-YL-365
3.57Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
3.45Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
3.33Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.33Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.23Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
3.12Single7SHEPI; PE7SHE-GPR158-PI; PE
3.03Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.78Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
gs_peptide gs_cck
gs_melanocortin
gs_vasop-oxy
gs_nucleotide gs_adenosine
gs_amine gs_5ht
gs_adrenergic
gs_dopamine
gs_histamine
gs_trace-amine
Net Summary
Imin 2.89572
Number of Linked Nodes 971
Number of Links 1135
Number of Hubs 161
Number of Links mediated by Hubs 650
Number of Communities 24
Number of Nodes involved in Communities 211
Number of Links involved in Communities 297
Path Summary
Number Of Nodes in MetaPath 132
Number Of Links MetaPath 131
Number of Shortest Paths 2616205
Length Of Smallest Path 3
Average Path Length 33.4371
Length of Longest Path 63
Minimum Path Strength 0.0785262
Average Path Strength 5.39709
Maximum Path Strength 19.2693
Minimum Path Correlation 0.70358
Average Path Correlation 0.96819
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.69492
Average % Of Corr. Nodes 32.2895
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.4127
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .




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