Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 7.2154104
2A:A:H41 5.436596
3A:A:L44 7.49254219
4A:A:V214 4.7375496
5A:A:F219 5.745698
6A:A:F222 12.964267
7A:A:Q227 6.1375419
8A:A:K233 5.145119
9A:A:C237 4.4025418
10A:A:F238 7.4675409
11A:A:I244 4.1185218
12A:A:F246 3.7175409
13A:A:V248 2.8075407
14A:A:Y253 8.182548
15A:A:F273 6.72754229
16A:A:W277 7.84254226
17A:A:W281 10.404515
18A:A:L289 3.615409
19A:A:N292 4.75254139
20A:A:I308 5.076547
21A:A:F312 4.075448
22A:A:F315 13.768546
23A:A:Y318 7.83833646
24A:A:P321 4.1125445
25A:A:E330 4.52403
26A:A:D331 9.4854284
27A:A:V334 4.06754284
28A:A:K338 8.93445
29A:A:Y339 5.025643
30A:A:F340 9.85429747
31A:A:D343 4.845443
32A:A:E344 6.65545
33A:A:F345 7.0125408
34A:A:S349 3.24754227
35A:A:R356 7.21402
36A:A:Y360 9.085408
37A:A:F363 7.458545
38A:A:T364 6.1545139
39A:A:D368 6.99754139
40A:A:F376 7.7725498
41A:A:R385 7.5375405
42A:A:L394 3.815408
43B:B:D27 8.9154298
44B:B:V40 5.494183
45B:B:H54 6.301676109
46B:B:K57 11.2775419
47B:B:M61 3.33466
48B:B:W63 5.556567
49B:B:D76 5.938336109
50B:B:I80 7.93254108
51B:B:I81 4.955407
52B:B:W82 9.5345109
53B:B:D83 8.64754208
54B:B:Y85 9.7325464
55B:B:N88 8.5854207
56B:B:K89 4.308336109
57B:B:I93 4.99407
58B:B:L95 4.0645248
59B:B:W99 8.36833609
60B:B:M101 4.742519
61B:B:Y105 4.4506
62B:B:I123 3.5625406
63B:B:Y124 4.915406
64B:B:H142 5.98167619
65B:B:Y145 6.26833618
66B:B:C149 3.37408
67B:B:F151 4.035619
68B:B:L152 3.82423
69B:B:N155 6.065413
70B:B:I157 4.155417
71B:B:T159 5.8125419
72B:B:D163 9.5175419
73B:B:C166 4.016528
74B:B:L168 2.8325426
75B:B:W169 6.91857718
76B:B:F180 6.998527
77B:B:H183 7.03167629
78B:B:V187 4.315429
79B:B:F199 7.092529
80B:B:V200 4.63456
81B:B:S201 4.955429
82B:B:C204 4.4225117
83B:B:D205 6.4875429
84B:B:K209 7.724526
85B:B:L210 3.14405
86B:B:W211 9.252528
87B:B:D212 6.53754309
88B:B:Q220 6.355457
89B:B:H225 8.33857759
90B:B:D228 7.6365119
91B:B:I229 4.075457
92B:B:I232 5.475458
93B:B:F234 3.2455
94B:B:F235 7.4256166
95B:B:P236 5.674167
96B:B:N237 6.6225165
97B:B:F241 4.80143756
98B:B:T243 4.446558
99B:B:D246 4.11254119
100B:B:D247 7.576559
101B:B:T249 4.585456
102B:B:R251 11.092558
103B:B:F253 9.0375456
104B:B:D258 9.0725457
105B:B:M262 5.4625484
106B:B:Y264 6.83485
107B:B:I269 3.372584
108B:B:F278 4.515167
109B:B:R283 6.735189
110B:B:Y289 5.59687
111B:B:D290 8.46416
112B:B:N295 7.142586
113B:B:W297 6.94488
114B:B:L300 4.75254186
115B:B:H311 7.0145179
116B:B:R314 12.842518
117B:B:L318 4.05754316
118B:B:W332 11.2583619
119B:B:D333 7.52254179
120B:B:K337 6.91254176
121B:B:W339 8.5754179
122G:G:R27 7.5675458
123G:G:Y40 8.47754166
124G:G:D48 6.112509
125G:G:N59 5.525469
126G:G:F61 5.36571768
127L:L:H7 5.1725400
128L:L:E9 5.5625470
129L:L:F12 5.035400
130L:L:F28 7.40833630
131L:L:I29 4.358530
132R:R:S31 7.89254194
133R:R:W39 10.3875405
134R:R:Y42 9.0175436
135R:R:P56 12.6954121
136R:R:F61 11.3456123
137R:R:C62 4.1054129
138R:R:F66 4.17754337
139R:R:Y69 5.63736
140R:R:W72 10.265409
141R:R:P86 5.36167638
142R:R:Y88 9.176535
143R:R:L89 5.65167635
144R:R:P90 4.31434
145R:R:W91 8.768534
146R:R:W110 10.735409
147R:R:Y148 5.015407
148R:R:Y152 4.45577
149R:R:L159 3.734509
150R:R:L166 3.085408
151R:R:L183 6.2775409
152R:R:F187 6.9375408
153R:R:R190 9.15678
154R:R:K197 5.06406
155R:R:Y205 7.95403
156R:R:Q213 4.17404
157R:R:W214 10.4917631
158R:R:R227 11.36254258
159R:R:F230 4.6454385
160R:R:Q234 6.71254157
161R:R:N240 9.1875409
162R:R:Y241 7.536578
163R:R:W243 10.046369
164R:R:L245 3.65408
165R:R:E247 7.5525409
166R:R:Y250 6.44358
167R:R:L255 3.884148
168R:R:Y269 4.37254357
169R:R:W274 5.75369
170R:R:P277 4.1975409
171R:R:F280 5.376676155
172R:R:W284 9.29754158
173R:R:E292 5.2625406
174R:R:W297 14.62254258
175R:R:Y305 6.9825404
176R:R:I309 5.3865157
177R:R:F321 5.2825406
178R:R:F324 5.36254149
179R:R:K334 4.17409
180R:R:T353 3.7054149
181R:R:L356 3.7685149
182R:R:H363 10.12254378
183R:R:E364 8.4725408
184R:R:E373 4.39404
185R:R:R380 4.675405
186R:R:T391 5.405476
187R:R:S392 4.17479
188R:R:Q394 5.55754379
189R:R:C403 3.91409
190R:R:N406 8.7054239
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:M61 B:B:W63 22.97633.49YesYes667
2B:B:C317 B:B:M61 23.52154.86NoYes076
3B:B:C317 B:B:S316 23.8763.44NoNo079
4B:B:S316 B:B:W332 24.05574.94NoYes099
5B:B:R314 B:B:W332 58.260820.99YesYes189
6B:B:R314 B:B:T274 60.0493.88YesNo188
7B:B:S275 B:B:T274 80.5143.2NoNo088
8B:B:L318 B:B:S275 80.67866.01YesNo068
9B:B:L318 B:B:T329 81.4492.95YesNo068
10B:B:H311 B:B:T329 55.13466.85YesNo098
11B:B:D333 B:B:H311 29.08125.04YesYes1799
12B:B:D333 B:B:F335 46.468610.75YesNo094
13B:B:F335 B:B:R52 46.48647.48NoNo047
14B:B:R52 R:R:R170 1004.26NoNo078
15R:R:H173 R:R:R170 99.97455.64NoNo078
16R:R:H173 R:R:Y178 99.94788.71NoNo076
17R:R:F266 R:R:Y178 99.92113.09NoNo066
18R:R:F266 R:R:I179 99.81322.51NoNo068
19R:R:E247 R:R:I179 44.58176.83YesNo098
20R:R:E247 R:R:H180 15.85066.15YesNo099
21R:R:H180 R:R:R176 15.72445.64NoNo099
22A:A:Y391 R:R:R176 14.196910.29NoNo049
23A:A:Y391 R:R:L251 14.0724.69NoNo049
24R:R:L251 R:R:L255 13.91962.77NoYes1498
25R:R:I330 R:R:L255 29.33162.85NoYes098
26R:R:I330 R:R:K334 29.1112.91NoYes099
27A:A:Q384 R:R:K334 24.80935.42NoYes069
28A:A:Q384 A:A:R380 24.46184.67NoNo067
29A:A:R380 R:R:F257 13.988112.83NoNo075
30B:B:H311 B:B:K337 26.78167.86YesYes1796
31B:B:K337 B:B:T50 53.5624.5YesNo063
32B:B:R52 B:B:T50 53.5749.06NoNo073
33B:B:T329 B:B:W339 26.63838.49NoYes089
34B:B:K337 B:B:W339 26.90349.28YesYes1769
35R:R:E247 R:R:L359 31.72383.98YesNo099
36R:R:L359 R:R:L360 31.00725.54NoNo099
37R:R:L356 R:R:L360 30.52954.15YesNo099
38R:R:L356 R:R:V327 16.01962.98YesNo1499
39R:R:L255 R:R:V327 15.86872.98YesNo1489
40A:A:L393 R:R:L356 17.08132.77NoYes089
41A:A:L393 R:R:V331 16.96562.98NoNo088
42A:A:L394 R:R:V331 15.77444.47YesNo088
43A:A:L394 R:R:K334 15.54382.82YesYes089
44A:A:N377 A:A:R380 10.13323.62NoNo047
45A:A:D381 R:R:K334 19.57495.53NoYes089
46A:A:D381 A:A:Y360 19.23310.34NoYes088
47A:A:D378 A:A:Y360 18.211313.79NoYes078
48A:A:N292 A:A:T364 10.5398.77YesYes1399
49B:B:M101 B:B:Y145 31.77914.79YesYes198
50B:B:W332 B:B:Y59 33.54714.82YesNo198
51B:B:M101 B:B:Y59 31.50545.99YesNo198
52A:A:L289 A:A:L291 11.29072.77YesNo098
53A:A:K280 A:A:R283 18.43164.95NoNo053
54A:A:R283 A:A:R356 18.21556.4NoYes032
55A:A:H357 A:A:R356 17.35383.39NoYes072
56A:A:H357 A:A:W277 17.159419.04NoYes076
57A:A:K280 B:B:D290 18.30052.77NoYes156
58A:A:F363 A:A:L291 12.13214.87YesNo058
59A:A:C359 A:A:W277 10.97522.61NoYes2256
60R:R:E247 R:R:L183 14.280913.25YesYes099
61B:B:L285 B:B:Y264 18.15984.69NoYes065
62B:B:F278 B:B:L285 17.59174.87YesNo076
63B:B:F235 B:B:F278 16.41967.5YesYes1667
64B:B:F235 B:B:N237 15.551812.08YesYes1665
65B:B:G238 B:B:N237 14.28223.39NoYes075
66B:B:F234 B:B:G238 13.55983.01YesNo057
67B:B:R68 B:B:Y85 10.314220.58NoYes054
68B:B:G162 B:B:Y145 24.27335.79NoYes198
69B:B:G162 B:B:S161 24.17713.71NoNo199
70B:B:H142 B:B:S161 23.383412.55YesNo199
71B:B:H142 B:B:W169 21.20493.17YesYes198
72B:B:I157 B:B:W169 17.243.52YesYes178
73B:B:I157 B:B:I171 13.45054.42YesNo176
74B:B:I171 B:B:N155 13.31515.66NoYes163
75B:B:D154 B:B:N155 11.92242.69NoYes063
76B:B:D153 B:B:D154 11.72315.32NoNo056
77B:B:D153 B:B:Q156 11.52369.14NoNo055
78B:B:L168 B:B:Q156 10.71742.66YesNo265
79B:B:L168 B:B:T178 10.32262.95YesNo264
80B:B:F180 B:B:T178 10.12495.19YesNo274
81B:B:S84 B:B:Y85 10.67923.82NoYes654
82B:B:W297 B:B:Y264 19.99811.58YesYes885
83B:B:W297 B:B:Y289 10.05345.79YesYes887
84B:B:D291 B:B:Y289 10.62783.45NoYes887
85B:B:D291 B:B:N293 10.83724.04NoNo085
86B:B:N295 B:B:V307 10.43394.43YesNo063
87B:B:N293 B:B:V307 10.61514.43NoNo053
88B:B:D312 B:B:D333 22.18213.99NoYes059
89B:B:D312 R:R:H171 22.1193.78NoNo057
90R:R:E412 R:R:H171 22.05674.92NoNo087
91R:R:E412 R:R:K415 21.87116.75NoNo087
92R:R:K415 R:R:R419 21.74716.19NoNo077
93B:B:A309 R:R:R419 21.62322.77NoNo037
94R:R:I179 R:R:W243 56.26923.52NoYes089
95R:R:S186 R:R:W243 27.28814.94NoYes099
96R:R:N240 R:R:S186 29.82227.45YesNo099
97R:R:N240 R:R:R190 35.448912.05YesYes098
98R:R:R190 R:R:V237 15.91513.08YesNo786
99L:L:H7 R:R:V237 18.58976.92YesNo006
100L:L:H7 R:R:Q234 16.8927.42YesYes007
101L:L:E9 R:R:R190 11.88018.14YesYes708
102L:L:E9 R:R:L388 11.79073.98YesNo007
103L:L:F12 R:R:Y148 10.95855.16YesYes007
104L:L:F12 L:L:V16 13.51775.24YesNo000
105L:L:L20 L:L:V16 13.03882.98NoNo000
106L:L:L20 R:R:Y205 11.605316.41NoYes003
107R:R:Q234 R:R:W284 16.30079.86YesYes1578
108R:R:K288 R:R:W284 42.12111.6NoYes088
109R:R:K288 R:R:W297 38.657617.4NoYes088
110R:R:R227 R:R:W297 37.848623.99YesYes2588
111R:R:D222 R:R:R227 37.06427.15NoYes068
112R:R:D222 R:R:Q221 36.79792.61NoNo064
113R:R:Q213 R:R:Q221 36.52223.84YesNo044
114R:R:L32 R:R:Q213 35.43922.66NoYes044
115R:R:L32 R:R:W214 35.16822.28NoYes041
116L:L:F28 R:R:W214 27.467615.03YesYes301
117L:L:F28 L:L:I29 22.20863.77YesYes300
118R:R:G273 R:R:W243 28.64058.44NoYes099
119R:R:G273 R:R:I272 28.54013.53NoNo096
120R:R:I272 R:R:V276 28.34754.61NoNo063
121R:R:V276 R:R:Y242 14.11657.57NoNo036
122R:R:F280 R:R:Y242 13.72274.13YesNo1556
123R:R:F280 R:R:I309 26.71332.51YesYes1557
124R:R:I309 R:R:W284 26.352212.92YesYes1578
125R:R:P277 R:R:V276 14.14083.53YesNo093
126R:R:F280 R:R:P277 13.76342.89YesYes059
127L:L:I29 R:R:L89 19.73782.85YesYes305
128R:R:L89 R:R:Y69 15.62964.69YesYes356
129R:R:V100 R:R:Y69 14.29445.05NoYes076
130R:R:V100 R:R:W72 14.01646.13NoYes079
131R:R:R102 R:R:W72 12.903818.99NoYes089
132R:R:R102 R:R:W110 12.625415.99NoYes089
133B:B:S84 B:B:W63 12.91573.71NoYes657
134A:A:C359 A:A:L289 10.81323.17NoYes059
135B:B:A309 B:B:N293 21.49944.69NoNo035
136B:B:D290 B:B:T274 20.30084.34YesNo168
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:H7 R:R:Q234 7.42 0 Yes Yes 0 7 0 1
L:L:H7 R:R:V237 6.92 0 Yes No 0 6 0 1
L:L:H7 R:R:W306 3.17 0 Yes No 0 6 0 1
L:L:A8 R:R:E387 6.03 0 No No 0 8 0 1
L:L:E9 R:R:Y152 4.49 7 Yes Yes 0 7 0 1
L:L:E9 R:R:R190 8.14 7 Yes Yes 0 8 0 1
L:L:E9 R:R:L388 3.98 7 Yes No 0 7 0 1
L:L:E9 R:R:T391 5.64 7 Yes Yes 0 6 0 1
L:L:T11 R:R:D372 5.78 0 No No 0 5 0 1
L:L:F12 R:R:L141 6.09 0 Yes No 0 5 0 1
L:L:F12 R:R:L144 3.65 0 Yes No 0 6 0 1
L:L:F12 R:R:Y148 5.16 0 Yes Yes 0 7 0 1
L:L:T13 R:R:K197 9.01 0 No Yes 0 6 0 1
L:L:S14 R:R:N300 2.98 0 No No 0 6 0 1
L:L:D15 R:R:R380 4.76 0 No Yes 0 5 0 1
L:L:S17 R:R:T298 6.4 0 No No 0 5 0 1
L:L:Y19 R:R:E138 17.96 0 No No 0 2 0 1
L:L:L20 R:R:Y205 16.41 0 No Yes 0 3 0 1
L:L:E21 R:R:S31 10.06 19 No Yes 0 4 0 1
L:L:E21 R:R:Y205 6.73 19 No Yes 0 3 0 1
L:L:E21 R:R:R299 8.14 19 No No 0 4 0 1
L:L:A24 R:R:Y205 2.67 0 No Yes 0 3 0 1
L:L:K26 R:R:E128 10.8 0 No No 0 3 0 1
L:L:F28 R:R:T35 2.59 3 Yes No 0 5 0 1
L:L:F28 R:R:V36 7.87 3 Yes No 0 2 0 1
L:L:F28 R:R:W214 15.03 3 Yes Yes 0 1 0 1
L:L:I29 R:R:T35 3.04 3 Yes No 0 5 0 1
L:L:I29 R:R:L89 2.85 3 Yes Yes 0 5 0 1
L:L:I29 R:R:P90 5.08 3 Yes Yes 0 4 0 1
L:L:I29 R:R:W91 7.05 3 Yes Yes 0 4 0 1
L:L:W31 R:R:W214 21.56 3 No Yes 0 1 0 1
L:L:L32 R:R:W39 22.78 3 No Yes 0 5 0 1
L:L:V33 R:R:Y69 5.05 3 No Yes 0 6 0 1
L:L:V33 R:R:L123 4.47 3 No No 0 5 0 1
R:R:T35 R:R:V30 3.17 3 No No 5 2 1 2
R:R:P90 R:R:V30 3.53 3 Yes No 4 2 1 2
R:R:S31 R:R:W33 6.18 19 Yes No 4 3 1 2
R:R:E34 R:R:S31 10.06 19 No Yes 4 4 2 1
R:R:R299 R:R:S31 5.27 19 No Yes 4 4 1 1
R:R:E34 R:R:W33 7.63 19 No No 4 3 2 2
R:R:E68 R:R:W39 3.27 0 No Yes 4 5 2 1
R:R:W39 R:R:Y88 13.5 0 Yes Yes 5 5 1 2
R:R:P86 R:R:Y69 6.95 3 Yes Yes 8 6 2 1
R:R:L89 R:R:Y69 4.69 3 Yes Yes 5 6 1 1
R:R:V100 R:R:Y69 5.05 0 No Yes 7 6 2 1
R:R:R121 R:R:Y69 3.09 3 No Yes 6 6 2 1
R:R:L123 R:R:Y69 10.55 3 No Yes 5 6 1 1
R:R:C126 R:R:Y69 4.03 0 No Yes 9 6 2 1
R:R:P86 R:R:Y88 6.95 3 Yes Yes 8 5 2 2
R:R:L89 R:R:P86 9.85 3 Yes Yes 5 8 1 2
R:R:L89 R:R:Y88 4.69 3 Yes Yes 5 5 1 2
R:R:L89 R:R:W91 10.25 3 Yes Yes 5 4 1 1
R:R:P90 R:R:W91 6.76 3 Yes Yes 4 4 1 1
R:R:E128 R:R:W91 18.54 0 No Yes 3 4 1 1
R:R:L123 R:R:R121 13.36 3 No No 5 6 1 2
R:R:L141 R:R:Q140 3.99 0 No No 5 4 1 2
R:R:L144 R:R:L384 2.77 0 No No 6 5 1 2
R:R:L144 R:R:L388 4.15 0 No No 6 7 1 1
R:R:Y145 R:R:Y148 2.98 0 No Yes 5 7 2 1
R:R:D198 R:R:Y145 4.6 0 No No 7 5 2 2
R:R:L388 R:R:Y148 9.38 0 No Yes 7 7 1 1
R:R:S392 R:R:Y148 2.54 7 Yes Yes 9 7 2 1
R:R:R190 R:R:Y152 5.14 7 Yes Yes 8 7 1 1
R:R:V194 R:R:Y152 5.05 0 No Yes 7 7 2 1
R:R:T391 R:R:Y152 3.75 7 Yes Yes 6 7 1 1
R:R:S392 R:R:Y152 3.82 7 Yes Yes 9 7 2 1
R:R:R190 R:R:V237 13.08 7 Yes No 8 6 1 1
R:R:N240 R:R:R190 12.05 0 Yes Yes 9 8 2 1
R:R:R190 R:R:Y241 11.32 7 Yes Yes 8 8 1 2
R:R:R190 R:R:T391 5.17 7 Yes Yes 8 6 1 1
R:R:D198 R:R:V194 4.38 0 No No 7 7 2 2
R:R:D198 R:R:K197 5.53 0 No Yes 7 6 2 1
R:R:K197 R:R:L201 2.82 0 Yes No 6 7 1 2
R:R:K197 R:R:M233 2.88 0 Yes No 6 6 1 2
R:R:M204 R:R:Y205 5.99 0 No Yes 3 3 2 1
R:R:Q210 R:R:Q211 6.4 3 No No 4 4 2 2
R:R:Q210 R:R:W214 15.33 3 No Yes 4 1 2 1
R:R:Q211 R:R:W214 6.57 3 No Yes 4 1 2 1
R:R:F230 R:R:T298 10.38 38 Yes No 5 5 2 1
R:R:M233 R:R:Q234 4.08 0 No Yes 6 7 2 1
R:R:Q234 R:R:W284 9.86 15 Yes Yes 7 8 1 2
R:R:I309 R:R:Q234 5.49 15 Yes Yes 7 7 2 1
R:R:V237 R:R:Y241 2.52 7 No Yes 6 8 1 2
R:R:E364 R:R:Y241 4.49 0 Yes Yes 8 8 2 2
R:R:I309 R:R:W284 12.92 15 Yes Yes 7 8 2 2
R:R:G295 R:R:R299 4.5 0 No No 4 4 2 1
R:R:N300 R:R:W306 13.56 0 No No 6 6 1 1
R:R:R310 R:R:W306 32.99 0 No No 6 6 2 1
R:R:E364 R:R:E387 6.34 0 Yes No 8 8 2 1
R:R:E364 R:R:T391 7.06 0 Yes Yes 8 6 2 1
R:R:D372 R:R:R380 5.96 0 No Yes 5 5 1 1
R:R:A375 R:R:R380 6.91 0 No Yes 4 5 2 1
R:R:E387 R:R:K383 10.8 0 No No 8 7 1 2
R:R:L32 R:R:W214 2.28 0 No Yes 4 1 2 1
L:L:E27 R:R:W214 2.18 0 No Yes 0 1 0 1
R:R:F66 R:R:W39 2 33 Yes Yes 7 5 2 1
L:L:A25 R:R:P90 1.87 0 No Yes 0 4 0 1
R:R:A92 R:R:L89 1.58 0 No Yes 5 5 2 1
R:R:S94 R:R:W91 1.24 0 No Yes 4 4 2 1
R:R:R376 R:R:R380 1.07 0 No Yes 5 5 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
90.91Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
90.00Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
86.36Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
82.61Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
79.17Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
76.00Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
76.00Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
75.00Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
75.00Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
73.08Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
72.00Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
72.00Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
70.83Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
70.83Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
69.23Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
69.23Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
68.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
68.00Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
68.00Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
66.67Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
66.67Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
65.38Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
65.38Consensusglp_onOrthosteric Ligandglp1_on glp2_on
65.38Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
64.00Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
64.00Consensuspac_onOrthosteric Ligandpac1_on
64.00Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
62.96Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
61.54Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
61.54Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
60.87Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
60.71Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
60.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
60.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
60.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
60.00Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
59.26Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
59.26Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
59.09Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
58.62Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
58.62Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
58.06Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
57.14Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
57.14Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
57.14Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
56.67Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
56.67Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
56.67Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
56.00Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
55.56Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
55.56Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
55.56Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
55.56Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
54.84Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
53.85Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
53.85Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
53.57Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
53.33Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
52.78Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
51.85Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
51.85Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
51.72Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
51.61Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
51.61Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
50.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
50.00Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
50.00Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
48.48Consensuspth_onOrthosteric Ligandpth1_on pth2_on
48.39Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
48.28Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
48.15Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
48.15Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
48.00Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
47.22Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
46.88Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
46.67Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
46.67Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
45.71Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
45.71Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
45.45Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
45.16Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
44.83Single6FJ3PTH6FJ3-PTH1-PTH
44.83Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
44.83Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
44.44Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
43.33Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
42.31Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
41.94Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
41.94Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
41.38Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
41.38Consensuscalcitonin_onOrthosteric Ligandctlike_on
41.38Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
41.18Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
41.18Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
40.74Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
40.00Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
40.00Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
40.00Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
40.00Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
39.29Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
37.93Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
37.93Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
37.50Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
37.50Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
37.50Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
37.50Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
37.14Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
36.11Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
35.48Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
35.29Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
34.62Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
34.62Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
34.48Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
34.48Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
34.38Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
34.38Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
34.38Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
34.38Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
34.38Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
34.29Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
34.29Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
33.33Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
33.33Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
33.33Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
33.33Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
33.33Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
33.33Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
32.35Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
32.14Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
31.43Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
31.25Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
31.25Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
31.25Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
31.25Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
31.03Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
31.03Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
30.77Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
30.77Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
30.56Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
30.30Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
30.30Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
30.30Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
30.30Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
30.30Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
30.00Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
29.73Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
29.63Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
29.41Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
29.41Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
29.41Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
29.17Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
29.17Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
29.17Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
29.03Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
29.03Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.03Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
29.03Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
29.03Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
29.03Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
29.03Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
29.03Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
28.57Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
28.57Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
28.57Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
28.57Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
28.57Consensusbombesin_onOrthosteric Ligandbb2_on
28.57Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
28.57Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
28.57Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
28.57Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
28.57Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
28.12Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
28.12Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
28.12Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
28.12Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
28.12Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
28.00Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Single9B9ZA1AKO9B9Z-CB1-A1AKO
27.78Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
27.78Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
27.59Single7QA8Peptide7QA8-STE2-Peptide
27.59Single7QA8Peptide7QA8-STE2-Peptide
27.59Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
27.59Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
27.59Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
27.50Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
27.27Single4XT3Fractalkine4XT3-US28-Fractalkine
27.27Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
27.27Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
27.27Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
27.27Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
27.27Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
27.27Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
27.27Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
27.03Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
26.92Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
26.92Single7TUYGSK682753A7TUY-GPR183-GSK682753A
26.67Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
26.67Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
26.67Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
26.67Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
26.47Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
26.47Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
26.47Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
26.47Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
26.47Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
26.47Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
26.47Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
26.47Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
26.32Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
26.19Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
26.09Single5U09Taranabant5U09-CB1-Taranabant
26.09Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
26.09Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
25.93Single6OS2TRV0266OS2-AT1-TRV026
25.93Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
25.93Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
25.93Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
25.81Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
25.81Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
25.81Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
25.81Consensusangiotensin_onOrthosteric Ligandat1_on
25.81Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
25.81Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
25.71Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
25.71Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
25.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
25.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
25.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
25.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
25.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
25.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
25.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
25.00Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
25.00Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
25.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
25.00Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
25.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.00Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
25.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
25.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
24.24Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
24.24Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
24.24Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
24.24Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
24.14Single4UG2CGS216804UG2-A2A-CGS21680
24.14Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
24.14Single7SK9CCX6627SK9-ACKR3-CCX662
24.14Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
24.14Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
24.14Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
24.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
24.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
24.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
24.00Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
24.00Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
24.00Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
24.00Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
24.00Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
24.00Consensushca_on_gpOrthosteric Ligandhca2_on_gp
23.53Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
23.53Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
23.33Single4XT1Fractalkine4XT1-US28-Fractalkine
23.33Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
23.33Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
23.33Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
23.33Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
23.33Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
23.33Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
23.33Consensuslpl_onOrthosteric Ligands1p_on lpa_on
23.33Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
23.33Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
23.33Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.08Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
23.08Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
23.08Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
23.08Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
23.08Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
23.08Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
23.08Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
23.08Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
23.08Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
23.08Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
23.08Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
23.08Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
22.86Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
22.86Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
22.86Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
22.86Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
22.86Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
22.58Single3QAKUK-4320973QAK-A2A-UK-432097
22.58Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
22.58Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
22.58Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
22.58Single7XNACYN1548067XNA-SST2-CYN154806
22.58Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
22.58Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
22.58Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
22.58Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
22.58Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
22.58Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
22.58Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
22.58Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
22.50Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
22.22Single2YDVNECA2YDV-A2A-NECA
22.22Single4UHRCGS216804UHR-A2A-CGS21680
22.22Single5G53NECA5G53-A2A-NECA-Gs
22.22Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
22.22Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
22.22Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
22.22Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
22.22Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
22.22Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
22.22Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
22.22Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
22.22Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
22.22Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
22.22Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
22.22Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
22.22Consensusrelaxin_onOrthosteric Ligandrxfp4_on
22.22Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
21.88Single5WF5UK-4320975WF5-A2A-UK-432097
21.88Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
21.88Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
21.88Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
21.88Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.88Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
21.88Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
21.88Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
21.88Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
21.88Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
21.88Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
21.74Single6LI0C176LI0-GPR52-C17
21.74Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
21.74Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
21.74Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
21.74Single8K5BNiacin8K5B-HCA2-Niacin
21.74Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
21.62Single5GLHEndothelin-15GLH-ETB-Endothelin-1
21.62Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
21.62Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
21.62Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
21.62Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
21.62Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
21.43Single4XEENeurotensin4XEE-NTS1-Neurotensin
21.43Single4XESNeurotensin4XES-NTS1-Neurotensin
21.43Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
21.43Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
21.43Single6YVRNTS8-136YVR-NTS1-NTS8-13
21.43Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
21.43Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
21.43Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
21.43Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
21.43Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
21.43Single8JWY2-1188JWY-A2A-2-118
21.43Single8JWZAB9288JWZ-A2A-AB928-Na
21.43Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
21.43Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
21.43Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.43Single8XYIVUF106618XYI-CXCR3-VUF10661
21.43Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
21.43Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
21.43Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
21.43Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
21.43Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
21.43Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
21.43Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
21.43Consensuslpa_offOrthosteric Ligandlpa1_off
21.43Consensuslpl_offOrthosteric Ligands1p_off lpa_off
21.43Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
21.43Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
21.21Single6JODAngiotensin II6JOD-AT2-Angiotensin II
21.21Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
21.21Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
21.21Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
21.21Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
21.21Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.21Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
21.21Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
21.21Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
20.83Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
20.83Single4BWBNeurotensin4BWB-NTS1-Neurotensin
20.83Single6AKXA4R6AKX-CCR5-A4R
20.83Single6AKYMaraviroc6AKY-CCR5-Maraviroc
20.83Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
20.83Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
20.83Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
20.83Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
20.83Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
20.83Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
20.83Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
20.83Single8IWESpermidine8IWE-TA9-Spermidine
20.83Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
20.83Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.83Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
20.83Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
20.83Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
20.83Consensusangiotensin_offOrthosteric Ligandat1_off
20.83Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.83Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
20.83Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.83Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.69Single4BUONeurotensin4BUO-NTS1-Neurotensin
20.69Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
20.69Single7EZCUKA7EZC-A2A-UKA
20.69Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
20.69Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
20.69Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
20.69Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
20.69Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
20.69Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
20.69Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
20.69Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
20.69Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
20.69Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
20.69Consensuschemerin_onOrthosteric Ligandcml1_on
20.69Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.69Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.69Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
20.59Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
20.59Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
20.59Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
20.59Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.59Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
20.59Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
20.59Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
20.59Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Single8ZRTET-18ZRT-ETB-ET-1
20.59Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
20.59Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
20.59Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.59Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
20.59Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
20.59Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
20.59Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
20.51Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
20.51Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
20.00Single2YDOAdenosine2YDO-A2A-Adenosine
20.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
20.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
20.00Single5WF6UK-4320975WF6-A2A-UK-432097
20.00Single5ZTYAM102575ZTY-CB2-AM10257
20.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
20.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
20.00Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
20.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7F61PF-036547467F61-H3-PF-03654746
20.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
20.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
20.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
20.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
20.00Single7T32ZM-2413857T32-A2A-ZM-241385
20.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
20.00Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
20.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
20.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
20.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
20.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
20.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
20.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
20.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
20.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
20.00Single8K5CAcipimox8K5C-HCA2-Acipimox
20.00Single8QJ2pN1628QJ2-MC4-pN162-Gs
20.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
20.00Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
20.00Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
20.00Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
20.00Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
20.00Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
20.00Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
20.00Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
20.00Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
20.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
20.00Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
20.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
20.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
20.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
20.00Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
20.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
20.00Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
20.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
20.00Consensushca_onOrthosteric Ligandhca2_on
20.00Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
20.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
20.00Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
19.44Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
19.44Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
19.44Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
19.44Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
19.44Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
19.35Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
19.35Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
19.35Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
19.35Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
19.35Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
19.35Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
19.35Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
19.35Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
19.35Single8WDTphotoNECA8WDT-A2A-photoNECA
19.35Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
19.35Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
19.35Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
19.35Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
19.35Consensussomatostatin_offOrthosteric Ligandsst2_off
19.23Single4YAYZD-71554YAY-AT1-ZD-7155
19.23Single5T04Neurotensin5T04-NTS1-Neurotensin
19.23Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
19.23Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
19.23Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
19.23Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
19.23Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
19.23Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
19.23Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
19.23Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
19.23Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
19.23Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
19.23Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
19.23Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
19.23Single8K5DGSK2560738K5D-HCA2-GSK256073
19.23Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
19.23Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
19.23Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
19.23Single9CHXS-Carazolol9CHX-β2-S-Carazolol
19.23Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
19.23Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
19.23Consensusa3_onOrthosteric Liganda3a_on
19.23Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
19.23Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
19.23Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
19.23Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
19.05Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
19.05Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
19.05Single8HS2Fab0468HS2-GPR20-Fab046
19.05Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
18.92Single6IGLIRL16206IGL-ETB-IRL1620
18.92Single8IY6Endothelin-18IY6-ETB-Endothelin-1
18.92Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
18.92Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
18.92Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
18.92Consensusbradykinin_onOrthosteric Ligandbk2_on
18.92Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
18.92Consensusendothelin_onOrthosteric Ligandetb_on eta_on
18.92Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
18.75Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
18.75Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
18.75Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
18.75Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
18.75Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
18.75Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
18.75Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
18.75Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
18.75Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
18.75Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
18.75Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
18.75Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
18.52Single4JKVTaladegib4JKV-SMO-Taladegib
18.52Single5C1MBU725C1M-μ-BU72
18.52Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
18.52Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
18.52Single6D26Fevipiprant6D26-DP2-Fevipiprant
18.52Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
18.52Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
18.52Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
18.52Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
18.52Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
18.52Single7C4SS1P7C4S-S1P3-S1P
18.52Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
18.52Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
18.52Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
18.52Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
18.52Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
18.52Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
18.52Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
18.52Single8S4DCMF-0198S4D-Apelin-CMF-019
18.52Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
18.52Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
18.52Single9EHSLUF76029EHS-A3A-LUF7602
18.52Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
18.52Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
18.52Consensusa3_on_gpOrthosteric Liganda3a_on_gp
18.52Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
18.52Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
18.52Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
18.52Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
18.52Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
18.52Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
18.52Consensusdp_offOrthosteric Liganddp2_off
18.52Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
18.52Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
18.52Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
18.52Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
18.52Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.52Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.52Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
18.52Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.52Consensustrace-amine_onOrthosteric Ligandta1_on
18.18Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
18.18Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
18.18Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
18.18Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.18Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.18Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
18.18Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
18.18Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
18.18Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
18.18Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
18.18Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
18.18Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
18.18Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
18.18Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
18.18Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
17.95Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
17.95Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
17.95Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
17.95Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
17.86Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
17.86Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
17.86Single4BV0Neurotensin4BV0-NTS1-Neurotensin
17.86Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
17.86Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
17.86Single5V56TC1145V56-SMO-TC114
17.86Single5V57TC1145V57-SMO-TC114
17.86Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
17.86Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
17.86Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
17.86Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
17.86Single6OS1TRV0266OS1-AT1-TRV026
17.86Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
17.86Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
17.86Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
17.86Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
17.86Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
17.86Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
17.86Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
17.86Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
17.86Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
17.86Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
17.86Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
17.86Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
17.86Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
17.86Single8E0GBU728E0G-μ-BU72
17.86Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
17.86Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
17.86Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
17.86Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
17.86Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
17.86Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
17.86Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
17.86Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
17.86Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
17.86Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
17.86Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
17.86Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
17.86Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
17.86Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
17.86Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
17.86Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
17.86Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
17.86Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
17.86Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
17.86Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
17.86Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
17.86Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
17.86Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
17.86Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
17.86Consensuslpa_onOrthosteric Ligandlpa1_on
17.86Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
17.86Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Consensusneurotensin_onOrthosteric Ligandnts1_on
17.86Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
17.86Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
17.86Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
17.86Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.86Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
17.65Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
17.65Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
17.65Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
17.65Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
17.65Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
17.65Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
17.65Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
17.65Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.65Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.65Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
17.65Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
17.65Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
17.65Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
17.65Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
17.39Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
17.39Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.39Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
17.39Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
17.39Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
17.39Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
17.39Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
17.39Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
17.39Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
17.39Single9LRCHistamine9LRC-H4-Histamine
17.39Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
17.39Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
17.39Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
17.24Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
17.24Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
17.24Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
17.24Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
17.24Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
17.24Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
17.24Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
17.24Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
17.24Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
17.24Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
17.24Single7K15MKD0467K15-BLT1-MKD046-Na
17.24Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
17.24Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
17.24Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
17.24Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
17.24Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
17.24Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
17.24Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
17.24Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
17.24Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
17.24Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
17.24Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
17.24Single9DGIZ85267113509DGI-CB1-Z8526711350
17.24Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
17.24Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
17.24Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
17.24Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
17.24Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
17.24Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
17.24Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
17.24Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
17.24Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
17.24Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
17.24Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
17.24Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
17.24Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
17.24Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
17.24Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
17.24Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
17.24Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
17.24Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
17.24Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
17.24Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
17.24Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
17.24Consensusorexin_onOrthosteric Ligandox2_on
17.24Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
17.14Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
17.14Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
17.14Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
17.14Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
17.14Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
17.14Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
17.14Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
16.67Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
16.67Single3OE9IT1t3OE9-CXCR4-IT1t
16.67Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
16.67Single4O9RCyclopamine4O9R-SMO-Cyclopamine
16.67Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
16.67Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
16.67Single5X93K-87945X93-ETB-K-8794
16.67Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
16.67Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
16.67Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
16.67Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
16.67Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
16.67Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
16.67Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
16.67Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
16.67Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
16.67Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
16.67Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
16.67Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
16.67Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
16.67Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
16.67Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
16.67Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
16.67Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
16.67Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
16.67Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
16.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
16.67Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
16.67Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
16.67Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
16.67Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
16.67Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
16.67Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.67Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8XVUCXCL28XVU-CXCR2-CXCL2
16.67Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
16.67Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
16.67Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
16.67Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
16.67Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
16.67Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
16.67Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
16.67Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
16.67Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
16.67Single9B9Y7DY9B9Y-CB1-7DY
16.67Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
16.67Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
16.67Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
16.67Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
16.67Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
16.67Consensuscck_onOrthosteric Ligandccka_on cckb_on
16.67Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
16.67Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
16.67Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
16.67Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
16.67Consensusendothelin_offOrthosteric Ligandetb_off
16.67Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
16.67Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
16.67Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
16.67Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
16.67Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
16.67Consensusprostanoid_offOrthosteric Ligandep_off dp_off
16.67Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
16.67Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
16.67Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
16.28Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
16.28Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
16.22Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
16.13Single3NY9ICI118-5513NY9-β2-ICI118-551
16.13Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
16.13Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
16.13Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.13Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
16.13Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
16.13Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
16.13Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
16.13Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
16.13Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
16.13Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
16.13Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
16.13Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
16.13Single9IPYJR14a9IPY-C3aB-JR14a
16.13Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
16.13Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
16.13Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
16.00Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
16.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
16.00Single4QINSAG1.54QIN-SMO-SAG1.5
16.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
16.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
16.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
16.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
16.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
16.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
16.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
16.00Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
16.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
16.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
16.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
16.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
16.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
16.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
16.00Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
16.00Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
16.00Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
16.00Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
16.00Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
16.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
16.00Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
16.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
16.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
16.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
16.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
16.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
16.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
16.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
16.00Single8Y0HVUF114188Y0H-CXCR3-VUF11418
16.00Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
16.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
16.00Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
16.00Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
16.00Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
16.00Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
16.00Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
16.00Consensusalpha2_offOrthosteric Ligandalpha2c_off
16.00Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
16.00Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
16.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
15.79Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
15.79Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
15.62Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
15.62Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
15.62Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
15.62Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
15.62Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
15.62Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
15.62Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
15.62Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
15.62Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
15.62Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.62Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.62Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
15.62Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
15.62Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
15.62Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
15.62Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
15.38Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
15.38Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
15.38Single5IU7Q274563465IU7-A2A-Q27456346-Na
15.38Single5IUBQ274563445IUB-A2A-Q27456344-Na
15.38Single5JTBZM-2413855JTB-A2A-ZM-241385
15.38Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
15.38Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
15.38Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
15.38Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
15.38Single6PS0S-Carazolol6PS0-β2-S-Carazolol
15.38Single6PS4ICI118-5516PS4-β2-ICI118-551
15.38Single6PS5S-Propranolol6PS5-β2-S-Propranolol
15.38Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
15.38Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
15.38Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
15.38Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
15.38Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
15.38Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
15.38Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
15.38Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
15.38Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
15.38Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
15.38Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
15.38Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
15.38Single7UL3Famotidine7UL3-H2-Famotidine
15.38Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
15.38Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
15.38Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.38Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
15.38Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
15.38Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
15.38Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
15.38Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
15.38Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
15.38Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
15.38Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
15.38Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
15.38Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
15.38Single8IHKAcifran8IHK-HCA3-Acifran
15.38Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
15.38Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
15.38Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
15.38Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
15.38Single8K2WAMG4878K2W-CXCR3-AMG487
15.38Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
15.38Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
15.38Single8RLNLUF58348RLN-A2A-LUF5834
15.38Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
15.38Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
15.38Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
15.38Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
15.38Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
15.38Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
15.38Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
15.38Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
15.38Single9AS5Mescaline9AS5-5-HT2A-Mescaline
15.38Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single9BA0A1AKN9BA0-CB1-A1AKN
15.38Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
15.38Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
15.38Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
15.38Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
15.38Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
15.38Consensusa2_offOrthosteric Liganda2a_off
15.38Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
15.38Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
15.38Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
15.38Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
15.38Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
15.38Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
15.38Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.15Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
15.15Single6HLOAprepitant6HLO-NK1-Aprepitant
15.15Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
15.15Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
15.15Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
15.15Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
15.15Single7SK5CXCL127SK5-ACKR3-CXCL12
15.15Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
15.15Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
15.15Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
15.15Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
15.00Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
14.81Single2Y04Salbutamol2Y04-β1-Salbutamol
14.81Single3EMLZM-2413853EML-A2A-ZM-241385
14.81Single3NY8ICI118-5513NY8-β2-ICI118-551
14.81Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
14.81Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
14.81Single4DAJTiotropium4DAJ-M3-Tiotropium
14.81Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
14.81Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
14.81Single4GBRS-Carazolol4GBR-β2-S-Carazolol
14.81Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
14.81Single4MQSIperoxo4MQS-M2-Iperoxo
14.81Single4QKX35V4QKX-β2-35V
14.81Single4U14Tiotropium4U14-M3-Tiotropium
14.81Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
14.81Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
14.81Single5DHHSB-6121115DHH-NOP-SB-612111
14.81Single5DSGTiotropium5DSG-M4-Tiotropium
14.81Single5IU8Q274563475IU8-A2A-Q27456347-Na
14.81Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
14.81Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
14.81Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
14.81Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
14.81Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
14.81Single5TGZAM65385TGZ-CB1-AM6538
14.81Single5UENDU1725UEN-A1-DU172
14.81Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
14.81Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
14.81Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
14.81Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
14.81Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
14.81Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
14.81Single6GPSMK08126GPS-CCR2-MK0812
14.81Single6H7MSalbutamol6H7M-β1-Salbutamol
14.81Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
14.81Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
14.81Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
14.81Single6PS1Timolol6PS1-β2-Timolol
14.81Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
14.81Single6S0LZM-2413856S0L-A2A-ZM-241385
14.81Single6TOTLemborexant6TOT-OX1-Lemborexant
14.81Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
14.81Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
14.81Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
14.81Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
14.81Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
14.81Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
14.81Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
14.81Single7PYRPSB-21157PYR-A2A-PSB-2115
14.81Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
14.81Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
14.81Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
14.81Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
14.81Single7UL4Alvimopan7UL4-μ-Alvimopan
14.81Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
14.81Single7V3ZCP559407V3Z-CB1-CP55940
14.81Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
14.81Single7WC7Lisuride7WC7-5-HT2A-Lisuride
14.81Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
14.81Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
14.81Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
14.81Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
14.81Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
14.81Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
14.81Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
14.81Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
14.81Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
14.81Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
14.81Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
14.81Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
14.81Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
14.81Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
14.81Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
14.81Single8JJOAlprenolol8JJO-β2-Alprenolol
14.81Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
14.81Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
14.81Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
14.81Single8T1WCVN4248T1W-GPR6-CVN424
14.81Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
14.81Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
14.81Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
14.81Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
14.81Single9AS1DMT9AS1-5-HT2A-DMT
14.81Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
14.81Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
14.81Single9H37A1IR09H37-A2A-A1IR0-Na
14.81Single9JEAAtropine9JEA-M1-Atropine
14.81Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
14.81Consensus5ht5_onOrthosteric Ligand5ht5a_on
14.81Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
14.81Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
14.81Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
14.81Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
14.81Consensusblt_onOrthosteric Ligandblt1_on
14.81Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
14.81Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
14.81Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
14.81Consensusdopamine_offOrthosteric Ligandd2_off d3_off
14.81Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
14.81Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
14.81Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
14.81Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
14.81Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
14.81Consensusleukotriene_onOrthosteric Ligandblt_on
14.81Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
14.81Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
14.81Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
14.81Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
14.71Single3OE0CVX153OE0-CXCR4-CVX15
14.71Single6PT2KGCHM076PT2-δ-KGCHM07
14.71Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
14.71Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.71Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
14.71Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
14.71Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
14.71Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single2RH1S-Carazolol2RH1-β2-S-Carazolol
14.29Single2Y03Isoprenaline2Y03-β1-Isoprenaline
14.29Single2YCWS-Carazolol2YCW-β1-S-Carazolol
14.29Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
14.29Single5D6LS-Carazolol5D6L-β2-S-Carazolol
14.29Single5IUAQ274563485IUA-A2A-Q27456348-Na
14.29Single5JQHS-Carazolol5JQH-β2-S-Carazolol
14.29Single5N2RPSB-365N2R-A2A-PSB-36-Na
14.29Single5N2SPSB365N2S-A1-PSB36
14.29Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
14.29Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
14.29Single5TVNLSD5TVN-5-HT2B-LSD
14.29Single5WIUNemonapride5WIU-D4-Nemonapride
14.29Single5WIVNemonapride5WIV-D4-Nemonapride-Na
14.29Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
14.29Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
14.29Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
14.29Single6E67BI1671076E67-β2-BI167107-Gs(CT)
14.29Single6GPXMK08126GPX-CCR2-MK0812
14.29Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
14.29Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
14.29Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.29Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
14.29Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
14.29Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
14.29Single6PS6Timolol6PS6-β2-Timolol
14.29Single6S0QZM-2413856S0Q-A2A-ZM-241385
14.29Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
14.29Single6TP6Filorexant6TP6-OX1-Filorexant
14.29Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
14.29Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
14.29Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
14.29Single7C61Ergotamine7C61-5-HT1B-Ergotamine
14.29Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
14.29Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
14.29Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
14.29Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
14.29Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
14.29Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
14.29Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
14.29Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
14.29Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
14.29Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
14.29Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
14.29Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
14.29Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GNEKW-63568GNE-A2A-KW-6356-Na
14.29Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
14.29Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
14.29Single8JXSPF-61428JXS-D1-PF-6142
14.29Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
14.29Single8QOTNanobody-E8QOT-μ-Nanobody-E
14.29Single8TF5Oleic acid8TF5-GPR6-Oleic acid
14.29Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
14.29Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
14.29Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
14.29Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
14.29Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
14.29Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
14.29Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
14.29Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
14.29Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
14.29Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
14.29Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
14.29Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
14.29Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
14.29Consensusadenosine_offOrthosteric Liganda1_off a2_off
14.29Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
14.29Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
14.29Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
14.29Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
14.29Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
14.29Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
14.29Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
14.29Consensusamine_offonOrthosteric Ligandamine_off amine_on
14.29Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
14.29Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
14.29Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
14.29Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
14.29Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
14.29Consensusblt_offOrthosteric Ligandblt1_off
14.29Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.29Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
14.29Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
14.29Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
14.29Consensusep_offOrthosteric Ligandep4_off
14.29Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
14.29Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
14.29Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
14.29Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
14.29Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
14.29Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
14.29Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
13.89Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
13.89Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
13.89Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
13.89Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.79Single3P0GBI1671073P0G-β2-BI167107
13.79Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
13.79Single4DJHJDTic4DJH-κ-JDTic
13.79Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
13.79Single4U15Tiotropium4U15-M3-Tiotropium
13.79Single5D5AS-Carazolol5D5A-β2-S-Carazolol
13.79Single5D5BS-Carazolol5D5B-β2-S-Carazolol
13.79Single5XR8AM8415XR8-CB1-AM841
13.79Single5XRAAM115425XRA-CB1-AM11542
13.79Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
13.79Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
13.79Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
13.79Single6H7JIsoprenaline6H7J-β1-Isoprenaline
13.79Single6J21Aprepitant6J21-NK1-Aprepitant
13.79Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
13.79Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
13.79Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.79Single6OL9Tiotropium6OL9-M5-Tiotropium
13.79Single6TQ7SB-3348676TQ7-OX1-SB-334867
13.79Single6WGTLSD6WGT-5-HT2A-LSD
13.79Single7B6WCyclazosin7B6W-α1b-Cyclazosin
13.79Single7F1TMIP-1a7F1T-CCR5-MIP-1a
13.79Single7FEECP559407FEE-CB1-CP55940-ZCZ011
13.79Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
13.79Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
13.79Single7PX4PSB-21137PX4-A2A-PSB-2113
13.79Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
13.79Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
13.79Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
13.79Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
13.79Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
13.79Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
13.79Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
13.79Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
13.79Single8EA0Iperoxo8EA0-M3-Iperoxo
13.79Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
13.79Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
13.79Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
13.79Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
13.79Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.79Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
13.79Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
13.79Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
13.79Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
13.79Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
13.79Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
13.79Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
13.79Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.79Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
13.79Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
13.79Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
13.79Single8ZWFJR14a8ZWF-C3aB-JR14a
13.79Single9AS9RS130-1809AS9-5-HT2A-RS130-180
13.79Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
13.79Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
13.79Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
13.79Consensusa2_onOrthosteric Liganda2b_on
13.79Consensusa2_on_gpOrthosteric Liganda2b_on_gp
13.79Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
13.79Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
13.79Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
13.79Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
13.79Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
13.79Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
13.79Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.79Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
13.79Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
13.79Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
13.79Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
13.79Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
13.79Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
13.79Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
13.79Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.79Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
13.79Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
13.79Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
13.79Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
13.64Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
13.64Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
13.64Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
13.64Single8PWNTheophylline8PWN-A2A-Theophylline
13.64Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
13.51Single7SK3CXCL127SK3-ACKR3-CXCL12
13.51Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
13.51Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
13.51Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
13.33Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
13.33Single3D4STimolol3D4S-β2-Timolol
13.33Single4AMIBucindolol4AMI-β1-Bucindolol
13.33Single4LDEBI1671074LDE-β2-BI167107
13.33Single4N4WSANT-14N4W-SMO-SANT-1
13.33Single5CXVTiotropium5CXV-M1-Tiotropium
13.33Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
13.33Single6A93Risperidone6A93-5-HT2A-Risperidone
13.33Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
13.33Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
13.33Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
13.33Single6IIURamatroban6IIU-TXA2-Ramatroban
13.33Single6KQICP559406KQI-CB1-CP55940-Org27569
13.33Single6MXTSalmeterol6MXT-β2-Salmeterol
13.33Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
13.33Single6ZG4HTL00099366ZG4-M1-HTL0009936
13.33Single7DFPSpiperone7DFP-D2-Spiperone
13.33Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
13.33Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
13.33Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
13.33Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
13.33Single7YITNalfurafine7YIT-κ-Nalfurafine
13.33Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
13.33Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
13.33Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
13.33Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
13.33Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
13.33Single8JJ8Formoterol8JJ8-β2-Formoterol
13.33Single8JJLOlodaterol8JJL-β2-Olodaterol
13.33Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
13.33Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
13.33Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
13.33Single8XWMCXCL68XWM-CXCR2-CXCL6
13.33Single8XWSCXCL58XWS-CXCR2-CXCL5
13.33Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
13.33Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
13.33Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
13.33Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
13.33Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
13.33Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
13.33Consensusalpha1_offOrthosteric Ligandalpha1a_off
13.33Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
13.33Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
13.33Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
13.33Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
13.33Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
13.33Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
13.33Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
13.33Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
13.33Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
13.33Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
13.16Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.04Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
13.04Single8A2OTheophylline8A2O-A2A-Theophylline-Na
13.04Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
13.04Single9CHUNoradrenaline9CHU-β2-Noradrenaline
13.04Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
12.90Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
12.90Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
12.90Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
12.90Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
12.90Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
12.90Single6H7LDobutamine6H7L-β1-Dobutamine
12.90Single6IBLArformoterol6IBL-β1-Arformoterol
12.90Single6K1QIRL25006K1Q-ETB-IRL2500
12.90Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
12.90Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
12.90Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
12.90Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
12.90Single7UM4AS26747237UM4-5-HT5A-AS2674723
12.90Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
12.90Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
12.90Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
12.90Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
12.90Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
12.90Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
12.90Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single8XVJMacitentan8XVJ-ETA-Macitentan
12.90Single8XWFCXCL38XWF-CXCR2-CXCL3
12.90Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
12.90Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
12.90Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
12.90Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
12.90Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
12.90Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
12.82Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
12.82Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
12.50Single3OE6IT1t3OE6-CXCR4-IT1t
12.50Single4XNWMRS25004XNW-P2Y1-MRS2500
12.50Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
12.50Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
12.50Single6ME5Agomelatine6ME5-MT1-Agomelatine
12.50Single6PT3DPI-2876PT3-δ-DPI-287
12.50Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
12.50Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
12.50Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
12.50Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
12.50Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
12.50Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
12.50Single7XN9L-054,5227XN9-SST2-L-054,522
12.50Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
12.50Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
12.50Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
12.50Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
12.50Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
12.50Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
12.50Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
12.50Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
12.50Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
12.50Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8X5YAstemizole8X5Y-H1-Astemizole
12.50Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
12.50Single8XQJJN2418XQJ-Apelin-JN241
12.50Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
12.50Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
12.50Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
12.50Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
12.50Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
12.50Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
12.50Consensus5ht2_onOrthosteric Ligand5ht2b_on
12.50Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
12.50Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.50Consensuskisspeptin_onOrthosteric Ligandkiss1_on
12.50Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
12.50Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
12.50Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
12.20Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
12.12Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
12.12Single4IARErgotamine4IAR-5-HT1B-Ergotamine
12.12Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
12.12Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
12.12Single7F8XNN90567F8X-CCKA-NN9056
12.12Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
12.12Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
12.12Single8XWNCXCL88XWN-CXCR2-CXCL8
12.12Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
12.12Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.12Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
12.12Single9M4TSilodosin9M4T-Alpha1A-Silodosin
12.12Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.12Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.12Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
12.12Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
12.12Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single5L7IVismodegib5L7I-SMO-Vismodegib
12.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
12.00Single7SRQLSD7SRQ-5-HT2B-LSD
12.00Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
12.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
12.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
12.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
12.00Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
12.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
12.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
12.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
12.00Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
12.00Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
12.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
12.00Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
12.00Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
12.00Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.00Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
12.00Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
12.00Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
12.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
12.00Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
11.76Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
11.76Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
11.76Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
11.76Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
11.76Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
11.76Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
11.76Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
11.76Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
11.54Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
11.54Single3ODUIT1t3ODU-CXCR4-IT1t
11.54Single3PWHZM-2413853PWH-A2A-ZM-241385
11.54Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
11.54Single4S0VSuvorexant4S0V-OX2-Suvorexant
11.54Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
11.54Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
11.54Single6B73MP11046B73-κ-MP1104
11.54Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
11.54Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
11.54Single6ME9Ramelteon6ME9-MT2-Ramelteon
11.54Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
11.54Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.54Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
11.54Single6TPJSuvorexant6TPJ-OX2-Suvorexant
11.54Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
11.54Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
11.54Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
11.54Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
11.54Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
11.54Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
11.54Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
11.54Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
11.54Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
11.54Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
11.54Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
11.54Single8GNGIstradefylline8GNG-A2A-Istradefylline
11.54Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
11.54Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
11.54Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
11.54Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
11.54Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
11.54Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.54Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.54Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.54Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
11.54Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
11.54Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
11.54Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
11.54Single9H2XA1IR19H2X-A2A-A1IR1-Na
11.54Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
11.54Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
11.54Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
11.54Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
11.54Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
11.54Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
11.54Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.54Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.54Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
11.54Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
11.54Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
11.54Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
11.54Consensusorexin_offOrthosteric Ligandox2_off ox1_off
11.54Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
11.54Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
11.54Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.43Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.43Single6W25SHU91196W25-MC4-SHU9119-Ca
11.43Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
11.11Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
11.11Single4ZJCSB-6740424ZJC-OX1-SB-674042
11.11Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
11.11Single5UVIZM-2413855UVI-A2A-ZM-241385
11.11Single6A94Zotepine6A94-5-HT2A-Zotepine
11.11Single6AQFZM-2413856AQF-A2A-ZM-241385
11.11Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
11.11Single6KUXRS-799486KUX-α2a-RS-79948
11.11Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
11.11Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.11Single6MH8ZM-2413856MH8-A2A-ZM-241385
11.11Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
11.11Single6TP3Nemorexant6TP3-OX1-Nemorexant
11.11Single6TPGEMPA6TPG-OX2-EMPA
11.11Single6V9SGTPL114036V9S-OX1-GTPL11403
11.11Single6VI4JDTic6VI4-κ-JDTic
11.11Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
11.11Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
11.11Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
11.11Single6ZG9GSK10347026ZG9-M1-GSK1034702
11.11Single7AROLUF58337ARO-A2A-LUF5833-Na
11.11Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
11.11Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
11.11Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
11.11Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
11.11Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
11.11Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
11.11Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
11.11Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
11.11Single7VV6C48/807VV6-MRGPRX2-C48/80
11.11Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
11.11Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
11.11Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
11.11Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
11.11Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
11.11Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
11.11Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
11.11Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
11.11Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
11.11Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
11.11Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
11.11Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
11.11Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8ZPMAMD0708ZPM-CXCR4-AMD070
11.11Single9AS3LSD9AS3-5-HT2A-LSD
11.11Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
11.11Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
11.11Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
11.11Consensusalpha1_onOrthosteric Ligandalpha1a_on
11.11Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
11.11Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
11.11Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
11.11Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
11.11Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
11.11Consensusgrh_offOrthosteric Ligandgnrh1_off
11.11Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
10.81Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
10.71Single2Y01Dobutamine2Y01-β1-Dobutamine
10.71Single2Y02Carmoterol2Y02-β1-Carmoterol
10.71Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
10.71Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
10.71Single4EJ4Naltrindole4EJ4-δ-Naltrindole
10.71Single4QIMANTA XV4QIM-SMO-ANTA XV
10.71Single5DHGC-355DHG-NOP-C-35
10.71Single5UIGCmpd-15UIG-A2A-Cmpd-1
10.71Single6D27CAY104716D27-DP2-CAY10471
10.71Single6DRXLisuride6DRX-5-HT2B-Lisuride
10.71Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
10.71Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
10.71Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
10.71Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
10.71Single7BU7BI1671077BU7-β1-BI167107
10.71Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
10.71Single7F83PF-051904577F83-Ghrelin-PF-05190457
10.71Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
10.71Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
10.71Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
10.71Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
10.71Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
10.71Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
10.71Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
10.71Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
10.71Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
10.71Single7YXAONO-54306087YXA-S1P5-ONO-5430608
10.71Single8CU6LJ-45178CU6-A2A-LJ-4517
10.71Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
10.71Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
10.71Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
10.71Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
10.71Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
10.71Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
10.71Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
10.71Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
10.71Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
10.71Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
10.71Single8JXRLSD8JXR-D1-LSD
10.71Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
10.71Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
10.71Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
10.71Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.71Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.71Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
10.71Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
10.71Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
10.71Single8X63Mepyramine8X63-H1-Mepyramine
10.71Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
10.71Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
10.71Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
10.71Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
10.71Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
10.71Single9IYAONO-97105319IYA-GPR55-ONO-9710531
10.71Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
10.71Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
10.71Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
10.71Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
10.71Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
10.71Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
10.71Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
10.71Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
10.71Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
10.71Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
10.71Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
10.71Consensusalpha2_onOrthosteric Ligandalpha2b_on
10.71Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
10.71Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
10.71Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
10.71Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
10.71Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
10.71Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
10.71Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
10.71Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
10.71Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
10.71Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
10.71Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
10.71Consensushistamine_offOrthosteric Ligandh1_off
10.71Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
10.34Single2Y00Dobutamine2Y00-β1-Dobutamine
10.34Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
10.34Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
10.34Single5CGCHTL142425CGC-mGlu5-HTL14242
10.34Single5WQCEMPA5WQC-OX2-EMPA
10.34Single5XPRBosentan5XPR-ETB-Bosentan
10.34Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
10.34Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
10.34Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
10.34Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
10.34Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
10.34Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
10.34Single7W41PD1762527W41-BB2-PD176252
10.34Single7WC6LSD7WC6-5-HT2A-LSD
10.34Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
10.34Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
10.34Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
10.34Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
10.34Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
10.34Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
10.34Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
10.34Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
10.34Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
10.34Single8ZMFA1L108ZMF-5-HT2C-A1L10
10.34Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
10.34Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
10.34Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
10.34Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
10.34Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
10.34Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
10.34Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
10.34Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
10.34Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
10.34Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
10.34Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
10.34Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
10.34Consensusbombesin_offOrthosteric Ligandbb2_off
10.34Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
10.34Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
10.34Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
10.26Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
10.26Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
10.26Single9KDFRES-701-39KDF-ETB-RES-701-3
10.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
10.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
10.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
10.00Single6J20Aprepitant6J20-NK1-Aprepitant
10.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
10.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
10.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
10.00Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
10.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
10.00Single7P2L4YI7P2L-mGlu5-4YI
10.00Single7R0CAVP7R0C-V2-AVP-Arrestin2
10.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
10.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
10.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
10.00Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
10.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
10.00Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
10.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
10.00Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
10.00Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
10.00Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
10.00Single9BJKNaloxone9BJK-μ-Naloxone-NAM
10.00Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
10.00Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
10.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
10.00Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
10.00Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
10.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
10.00Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
9.68Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
9.68Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
9.68Single4RWADIPP-NH24RWA-δ-DIPP-NH2
9.68Single5X33BIIL2605X33-BLT1-BIIL260
9.68Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
9.68Single6CM4Risperidone6CM4-D2-Risperidone
9.68Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
9.68Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
9.68Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.68Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
9.68Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
9.68Single8XQJJN2418XQJ-Apelin-JN241
9.68Single8XWACXCL18XWA-CXCR2-CXCL1
9.68Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
9.68Single9BJKNAM9BJK-μ-Naloxone-NAM
9.68Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
9.68Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
9.68Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.68Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.38Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
9.38Single5CGDHTL142425CGD-mGlu5-HTL14242
9.38Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
9.38Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
9.38Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.38Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
9.38Single8ZPLHF511168ZPL-CXCR4-HF51116
9.38Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.38Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
9.09Single5MZPCaffeine5MZP-A2A-Caffeine-Na
9.09Single6KNMJN241-96KNM-Apelin-JN241-9
9.09Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
9.09Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
9.09Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
9.09Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
9.09Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
9.09Single9JF4PD1683689JF4-BB1-PD168368
9.09Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
8.82Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
8.82Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.82Single8IEBA1LYA8IEB-GPR156-A1LYA
8.82Single8IEIA1LYA8IEI-GPR156-A1LYA
8.82Single8IEPA1LYA8IEP-GPR156-A1LYA
8.82Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.82Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
8.82Single8KIGSHU91198KIG-MC3-SHU9119-Ca
8.82Single8WKYPG-9348WKY-MC4-PG-934
8.82Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
8.82Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
8.70Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
8.57Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
8.57Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
8.57Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
8.33Single3OE8IT1t3OE8-CXCR4-IT1t
8.33Single3RFMCaffeine3RFM-A2A-Caffeine
8.33Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
8.33Single6TQ9SB-4081246TQ9-OX1-SB-408124
8.33Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
8.33Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
8.33Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
8.33Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
8.33Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
8.33Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
8.33Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
8.33Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
8.33Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.33Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.33Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
8.33Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
8.33Consensusp2y_offOrthosteric Ligandp2y1_off
8.11Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
8.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
8.00Single3UZAGTPL92363UZA-A2A-GTPL9236
8.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
8.00Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
8.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
8.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.00Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
8.00Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
8.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
8.00Single8JPSCCL78JPS-ACKR1-CCL7
8.00Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
8.00Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
7.89Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
7.69Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
7.69Single3PBLEticlopride3PBL-D3-Eticlopride
7.69Single6HLLCP999946HLL-NK1-CP99994
7.69Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
7.69Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.69Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
7.69Single7UL2SR486927UL2-NTS1-SR48692-Na
7.69Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
7.69Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
7.69Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
7.69Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
7.69Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
7.69Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
7.69Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
7.69Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
7.69Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
7.69Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
7.69Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.69Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.69Single9AS7Psilocin9AS7-5-HT2A-Psilocin
7.69Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
7.69Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
7.69Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
7.69Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
7.69Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
7.69Consensusgq_nucleotideOrthosteric Ligandgq_p2y
7.69Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
7.69Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
7.69Consensusneurotensin_offOrthosteric Ligandnts1_off
7.69Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
7.41Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
7.41Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
7.41Single5WS3EMPA5WS3-OX2-EMPA
7.41Single6DS0Ly2660976DS0-5-HT2B-Ly266097
7.41Single6TODEMPA6TOD-OX1-EMPA-Na
7.41Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
7.41Single7BR3Elagolix7BR3-GnRH1-Elagolix
7.41Single7F8ULintitript7F8U-CCKA-Lintitript
7.41Single7F8YDevazepide7F8Y-CCKA-Devazepide
7.41Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.41Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
7.41Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
7.41Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
7.41Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
7.41Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
7.41Single7XRRLemborexant7XRR-OX2-Lemborexant
7.41Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
7.41Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
7.41Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
7.41Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
7.41Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
7.41Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
7.41Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
7.41Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
7.41Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
7.41Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
7.14Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
7.14Single3REYXAC3REY-A2A-XAC
7.14Single3RZECidoxepin3RZE-H1-Cidoxepin
7.14Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
7.14Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
7.14Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
7.14Single6FFIMMPEP6FFI-mGlu5-MMPEP
7.14Single6IQLL7458706IQL-D4-L745870
7.14Single6TPNHTL66416TPN-OX2-HTL6641
7.14Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
7.14Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
7.14Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
7.14Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
7.14Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8JD6VU03647708JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
7.14Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
7.14Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.14Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
7.14Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.14Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
7.14Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
7.14Single8ZPNAMD31008ZPN-CXCR4-AMD3100
7.14Single9ARXSerotonin9ARX-5-HT2A-Serotonin
7.14Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
7.14Consensusopsins_offOrthosteric Ligandrhodopsin_off
7.14Consensussensory_offOrthosteric Ligandopsins_off
6.90Single6FFHFenobam6FFH-mGlu5-Fenobam
6.90Single6IIVDaltroban6IIV-TXA2-Daltroban
6.90Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
6.90Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
6.90Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
6.90Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
6.90Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.90Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
6.90Single8X64Desloratadine8X64-H1-Desloratadine
6.90Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
6.90Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
6.90Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
6.90Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
6.90Consensuscck_offOrthosteric Ligandccka_off
6.90Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
6.67Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
6.67Single6LUQHaloperidol6LUQ-D2-Haloperidol
6.67Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
6.67Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
6.67Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
6.67Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
6.67Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
6.67Single7SINNPS-21437SIN-CaS-NPS-2143
6.67Single7SINNPS-21437SIN-CaS-NPS-2143
6.67Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.67Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
6.67Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
6.67Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
6.67Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
6.67Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
6.67Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
6.67Single9HAPTolvaptan9HAP-V2-Tolvaptan
6.67Single9HC04YI9HC0-mGlu5-4YI
6.67Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
6.45Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
6.45Single5TZRMK86665TZR-FFA1-MK8666
6.45Single6E59L-7607356E59-NK1-L-760735
6.45Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
6.45Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
6.45Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
6.45Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
6.45Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
6.45Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
6.45Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
6.45Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
6.45Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
6.45Single8XVLZibotentan8XVL-ETA-Zibotentan
6.45Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
6.45Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
6.45Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
6.45Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
6.45Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
6.45Consensustachykinin_offOrthosteric Ligandnk1_off
6.25Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
6.25Single4PY02MeSATP4PY0-P2Y12-2MeSATP
6.25Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
6.25Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
6.25Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
6.25Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
6.25Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
6.25Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
6.06Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
6.06Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
6.06Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
6.06Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
6.06Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
5.88Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
5.88Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
5.88Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
5.71Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
5.71Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.71Single8IEIA1LYA8IEI-GPR156-A1LYA
5.71Single8IEPA1LYA8IEP-GPR156-A1LYA
5.71Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.71Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.56Single8IEBA1LYA8IEB-GPR156-A1LYA
5.56Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.56Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
5.26Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
5.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.00Single6D35Cholesterol6D35-SMO-Cholesterol
5.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
5.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
5.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
5.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
5.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
5.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
5.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
5.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
5.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
5.00Single7DTTCa7DTT-CaS-Ca-Ca
5.00Single7DTTCa7DTT-CaS-Ca-Ca
5.00Single7DTUTryptophan7DTU-CaS-Tryptophan
5.00Single7DTUTryptophan7DTU-CaS-Tryptophan
5.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.00Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
5.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
5.00Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
5.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
5.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
5.00Single7XW7K1-707XW7-TSH-K1-70
5.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
5.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
5.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
5.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
5.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.00Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
5.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
5.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
5.00Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
5.00Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
5.00Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
5.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8WVXNorrin8WVX-LGR4-Norrin
5.00Single8WVYNorrin8WVY-LGR4-Norrin
5.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.00Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
5.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.00Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.00Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
5.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
5.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.00Single9KHHNorrin9KHH-LGR4-Norrin
5.00Single9S37NB219S37-LGR4-NB21
5.00Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
4.76Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.76Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.76Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.76Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.76Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.76Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.76Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.76Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.76Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.76Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
4.76Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
4.55Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
4.55Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.55Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
4.55Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.35Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.35Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
4.35Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
4.35Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
4.35Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.35Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single5L7DCholesterol5L7D-SMO-Cholesterol
4.17Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
4.17Single7WC4Serotonin7WC4-5-HT2A-Serotonin
4.17Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
4.00Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
4.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.00Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
4.00Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
4.00Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.00Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
4.00Consensussensory_onOrthosteric Ligandopsins_on
3.85Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
3.85Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
3.85Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
3.85Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
3.85Single7WC5Psilocin7WC5-5-HT2A-Psilocin
3.85Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.85Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
3.85Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
3.85Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
3.85Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
3.85Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
3.85Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
3.85Consensusgi_sensoryOrthosteric Ligandgi_opsins
3.85Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
3.85Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
3.85Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
3.85Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
3.85Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
3.70Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
3.70Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
3.70Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
3.70Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
3.70Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
3.70Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
3.70Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
3.70Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
3.70Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
3.70Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
3.70Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.70Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
3.70Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.70Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
3.70Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.70Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.57Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
3.57Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
3.57Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
3.57Single4XNVBPTU4XNV-P2Y1-BPTU
3.57Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
3.57Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
3.57Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.57Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.57Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.57Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.57Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.57Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
3.57Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
3.57Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
3.57Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
3.57Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.57Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.57Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
3.57Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.57Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.57Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.57Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.57Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
3.45Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
3.45Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
3.45Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
3.45Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
3.45Single6TPKRetosiban6TPK-OT-Retosiban
3.45Single7VODCariprazine7VOD-5-HT2A-Cariprazine
3.45Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
3.45Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
3.45Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
3.45Single8IYXYL-3658IYX-GPR34-YL-365
3.45Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.45Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
3.45Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.45Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
3.45Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
3.45Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
3.45Consensusvasop-oxy_offOrthosteric Ligandot_off
3.33Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
3.33Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
3.33Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
3.33Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
3.33Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
3.33Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
3.33Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
3.23Single4NTJAZD12834NTJ-P2Y12-AZD1283
3.23Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
3.23Single6HLPNetupitant6HLP-NK1-Netupitant
3.23Single6Z4SSR486926Z4S-NTS1-SR48692
3.23Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
3.23Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
3.12Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
3.12Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.12Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
3.03Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
3.03Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.03Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
3.03Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
2.94Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
2.86Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
2.86Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
2.78Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.78Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.63Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.63Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.56Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.38Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

PDB Summary
PDB 9EBO
Class B1
SubFamily Peptide
Type Glucagon
SubType GLP-1
Species Homo Sapiens
Ligand GLP-1 (ACPC18)
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.13
Date 2025-03-26
D.O.I. doi.org/10.1073/pnas.2407574122
Net Summary
Imin 2.51
Number of Linked Nodes 965
Number of Links 1178
Number of Hubs 190
Number of Links mediated by Hubs 681
Number of Communities 38
Number of Nodes involved in Communities 282
Number of Links involved in Communities 394
Path Summary
Number Of Nodes in MetaPath 137
Number Of Links MetaPath 136
Number of Shortest Paths 2789200
Length Of Smallest Path 3
Average Path Length 36.9501
Length of Longest Path 74
Minimum Path Strength 1.285
Average Path Strength 6.28503
Maximum Path Strength 24.625
Minimum Path Correlation 0.7
Average Path Correlation 0.99063
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.43902
Average % Of Corr. Nodes 47.2214
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.9622
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • heart process   • multicellular organismal process   • system process   • regulation of biological process   • regulation of heart contraction   • regulation of system process   • circulatory system process   • regulation of blood circulation   • regulation of multicellular organismal process   • heart contraction   • blood circulation   • regulation of blood pressure   • positive regulation of blood pressure   • cellular response to stimulus   • regulation of cellular process   • response to stimulus   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to stress   • response to psychosocial stress   • cell surface receptor signaling pathway   • behavior   • learning or memory   • nervous system process   • cognition   • transport   • secretion   • regulation of hormone levels   • cell-cell signaling   • export from cell   • hormone secretion   • establishment of localization   • localization   • secretion by cell   • signal release   • hormone transport   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • establishment of protein localization   • cellular localization   • nitrogen compound transport   • protein targeting   • protein transmembrane transport   • establishment of localization in cell   • post-translational protein targeting to membrane, translocation   • intracellular protein localization   • establishment of protein localization to endoplasmic reticulum   • establishment of protein localization to membrane   • intracellular protein transmembrane transport   • intracellular transport   • post-translational protein targeting to endoplasmic reticulum membrane   • localization within membrane   • protein targeting to membrane   • transmembrane transport   • establishment of protein localization to organelle   • protein transport   • macromolecule localization   • intracellular protein transport   • protein targeting to ER   • negative regulation of blood pressure   • cellular anatomical structure   • membrane   • cell periphery   • plasma membrane   • hormone activity   • protein binding   • binding   • molecular function activator activity   • signaling receptor binding   • molecular function regulator activity   • signaling receptor regulator activity   • receptor ligand activity   • signaling receptor activator activity   • G protein-coupled receptor binding   • glucagon receptor binding   • identical protein binding   • monosaccharide metabolic process   • positive regulation of biological process   • gluconeogenesis   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • small molecule metabolic process   • regulation of carbohydrate metabolic process   • regulation of glucose metabolic process   • positive regulation of cellular process   • positive regulation of gluconeogenesis   • regulation of biosynthetic process   • carbohydrate metabolic process   • small molecule biosynthetic process   • carbohydrate biosynthetic process   • hexose metabolic process   • primary metabolic process   • monosaccharide biosynthetic process   • hexose biosynthetic process   • positive regulation of glucose metabolic process   • biosynthetic process   • regulation of gluconeogenesis   • metabolic process   • positive regulation of carbohydrate metabolic process   • regulation of carbohydrate biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • glucose metabolic process   • regulation of localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • amide transport   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • regulation of protein transport   • protein secretion   • regulation of protein secretion   • regulation of secretion   • peptide transport   • regulation of insulin secretion   • peptide hormone secretion   • regulation of cell communication   • insulin secretion   • positive regulation of cell communication   • positive regulation of establishment of protein localization   • carbohydrate homeostasis   • positive regulation of insulin secretion involved in cellular response to glucose stimulus   • positive regulation of insulin secretion   • positive regulation of peptide hormone secretion   • intracellular glucose homeostasis   • cellular response to oxygen-containing compound   • cellular response to carbohydrate stimulus   • chemical homeostasis   • response to glucose   • response to chemical   • glucose homeostasis   • positive regulation of protein localization   • insulin secretion involved in cellular response to glucose stimulus   • homeostatic process   • positive regulation of secretion by cell   • positive regulation of protein transport   • positive regulation of hormone secretion   • response to monosaccharide   • response to carbohydrate   • positive regulation of secretion   • cellular response to hexose stimulus   • intracellular chemical homeostasis   • cellular response to monosaccharide stimulus   • positive regulation of peptide secretion   • response to oxygen-containing compound   • cellular response to glucose stimulus   • positive regulation of protein secretion   • response to hexose   • cellular response to chemical stimulus   • cellular homeostasis   • positive regulation of transport   • regulation of cellular localization   • regulation of insulin secretion involved in cellular response to glucose stimulus   • positive regulation of signaling   • positive regulation of signal transduction   • regulation of signal transduction   • intracellular signal transduction   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • intracellular signaling cassette   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • MAPK cascade   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • regulation of calcium ion import   • regulation of calcium ion transport   • positive regulation of calcium ion transport   • positive regulation of calcium ion import   • regulation of monoatomic ion transport   • calcium ion transport   • metal ion transport   • positive regulation of monoatomic ion transport   • monoatomic ion transport   • calcium ion import   • monoatomic cation transport   • regulation of metal ion transport   • lipid biosynthetic process   • lipid metabolic process   • negative regulation of programmed cell death   • regulation of apoptotic process   • negative regulation of biological process   • regulation of programmed cell death   • cell death   • negative regulation of apoptotic process   • negative regulation of cellular process   • apoptotic process   • programmed cell death   • cellular response to nitrogen compound   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to nitrogen compound   • response to glucagon   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • response to hormone   • cellular response to hormone stimulus   • lactate biosynthetic process   • monocarboxylic acid biosynthetic process   • oxoacid metabolic process   • carboxylic acid metabolic process   • organic acid biosynthetic process   • organic acid metabolic process   • carboxylic acid biosynthetic process   • lactate metabolic process   • monocarboxylic acid metabolic process   • response to activity   • negative regulation of execution phase of apoptosis   • regulation of execution phase of apoptosis   • execution phase of apoptosis   • intracellular anatomical structure   • cytoplasm   • extracellular region   • extracellular space   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • organelle   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • sensory perception of smell   • skeletal system development   • bone development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • coagulation   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • developmental growth   • growth   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • renal system process   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • endomembrane system   • trans-Golgi network
Gene OntologyCellular Component
SCOP2Domain Identifier• FnI-like domain   • G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• FnI-like domain   • G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeXCP
PDB ResiduesL:L:?18
Environment DetailsOpen EMBL-EBI Page
CodeXCP
Name(1S,2S)-2-aminocyclopentanecarboxylic acid
Synonyms
Identifier
FormulaC6 H11 N O2
Molecular Weight129.157
SMILES
PubChem10997062
Formal Charge0
Total Atoms20
Total Chiral Atoms2
Total Bonds20
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9EBO_Chain_A
EKAQREANK KIEKQLQKD KQVYRATHR LLLLGAGES GKTIVKQMR 
TSGIFETKF QVDKVNFHM FDVGQRDER RKWIQCFND VTAIIFVVA 
SSSYNQTNR LQALLFSIW NNWLRSVIL FLNKQDLLA EKVLAGKSK 
IEDYFPEFA RYTTPEDAT PEPGEDPRV TRAKYFIRD EFLRISTAS 
GDGRHYCYP HFTCAVDTE NIRRVFNDC RDIIQRMHL RQYELLNAA 
KDKDT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9EBO_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9EBO_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF R


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP43220
Sequence
>9EBO_Chain_R
VSLWETVQK WREYRRQCQ RSLTEDPPP ATDLFCNRT FDEYACWPD 
GEPGSFVNV SCPWYLPWA SSVPQGHVY RFCTAEGLW LQKDNSSLP 
WRDLSECEE SEEQLLFLY IIYTVGYAL SFSALVIAS AILLGFRHL 
HCTRNYIHL NLFASFILR ALSVFIKDA ALKWMYSTA AQQHQWDSY 
QDSLSCRLV FLLMQYCVA ANYYWLLVE GVYLYTLLA FSVSEQWIF 
RLYVSIGWG VPLLFVVPW GIVKYLYED EGCWTRNSN MNYWLIIRL 
PILFAIGVN FLIFVRVIC IVVSKLKAN DIKCRLAKS TLTLIPLLG 
THEVIFAFV MDEHARGTL RFIKLFTEL SFTSFQGLM VAILYCFVN 
NEVQLEFRK SWERWRLEF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6ORVB1PeptideGlucagonGLP-1Homo sapiens-TT-OAD2Gs/β1/γ232020-01-08doi.org/10.1038/s41586-019-1902-z
6ORV (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-TT-OAD232020-01-08doi.org/10.1038/s41586-019-1902-z
7E14B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 156022738Gs/β1/γ22.92021-07-07doi.org/10.1038/s41467-021-24058-z
7E14 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 1560227382.92021-07-07doi.org/10.1038/s41467-021-24058-z
7DUQB1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 156022738Gs/β1/γ22.52021-07-14doi.org/10.1038/s41467-021-24058-z
7DUQ (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 1560227382.52021-07-14doi.org/10.1038/s41467-021-24058-z
7DURB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ23.32021-08-11doi.org/10.1038/s41467-021-24058-z
7DUR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227383.32021-08-11doi.org/10.1038/s41467-021-24058-z
7EVMB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ22.52021-08-11doi.org/10.1038/s41467-021-24058-z
7EVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227382.52021-08-11doi.org/10.1038/s41467-021-24058-z
5VEWB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.72017-05-24doi.org/10.1038/nature22378
6LN2B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-3.22020-03-18doi.org/10.1038/s41467-020-14934-5
6KJVB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.82019-11-13doi.org/10.1107/S2052252519013496
6KK1B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.82019-11-13doi.org/10.1107/S2052252519013496
6KK7B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-3.12019-11-13doi.org/10.1107/S2052252519013496
5VEXB1PeptideGlucagonGLP-1Homo sapiens-NNC0640-32017-05-17doi.org/10.1038/nature22378
9IVMB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN3318839chim(NtGi1-Gs)/β2/γ23.222024-11-13doi.org/10.1016/j.apsb.2024.09.002
9IVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN33188393.222024-11-13doi.org/10.1016/j.apsb.2024.09.002
6VCBB1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN3160440Gs/β1/γ23.32020-07-22doi.org/10.1038/s41589-020-0589-7
6VCB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN31604403.32020-07-22doi.org/10.1038/s41589-020-0589-7
9IVGB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ232024-11-27doi.org/10.1016/j.apsb.2024.09.002
9IVG (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-32024-11-27doi.org/10.1016/j.apsb.2024.09.002
7RTBB1PeptideGlucagonGLP-1Homo sapiensPeptide-19-Gs/β1/γ22.142021-10-06doi.org/10.1016/j.bbrc.2021.09.016
7RTB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-19-2.142021-10-06doi.org/10.1016/j.bbrc.2021.09.016
7KI0B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-Gs/β1/γ22.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI0 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-2.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI1B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-Gs/β1/γ22.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI1 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-2.52021-08-04doi.org/10.1016/j.celrep.2021.109374
6X18B1PeptideGlucagonGLP-1Homo sapiensGLP-1-Gs/β1/γ22.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X18 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1-2.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X19B1PeptideGlucagonGLP-1Homo sapiensCHU-128-Gs/β1/γ22.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X19 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensCHU-128-2.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X1AB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.52020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X1A (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.52020-09-09doi.org/10.1016/j.molcel.2020.09.020
7LCIB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.92021-01-20doi.org/10.1016/j.str.2021.04.008
7LCI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.92021-01-20doi.org/10.1016/j.str.2021.04.008
7LCJB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--2.822021-01-20doi.org/10.1016/j.str.2021.04.008
7LCKB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--3.242021-01-20doi.org/10.1016/j.str.2021.04.008
7S15B1PeptideGlucagonGLP-1Homo sapiensPubChem 134611223--3.82022-06-08doi.org/10.1021/acs.jmedchem.1c01856
9J1PB1PeptideGlucagonGLP-1Homo sapiensg1:Ox-chim(NtGi1-Gs)/β1/γ22.992025-02-26doi.org/10.1021/jacs.4c12808
9J1P (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensg1:Ox-2.992025-02-26doi.org/10.1021/jacs.4c12808
5VAIB1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-Gs/β1/γ24.12017-05-24doi.org/10.1038/nature22394
5VAI (No Gprot) B1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-4.12017-05-24doi.org/10.1038/nature22394
5NX2B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)--3.72017-06-14doi.org/10.1038/nature22800
6B3JB1PeptideGlucagonGLP-1Homo sapiensExendin-P5-Gs/β1/γ23.32018-02-21doi.org/10.1038/nature25773
6B3J (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-P5-3.32018-02-21doi.org/10.1038/nature25773
8WG7B1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.542024-03-06doi.org/10.1038/s41421-024-00649-0
8WG7 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.542024-03-06doi.org/10.1038/s41421-024-00649-0
7C2EB1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-Gs/β1/γ24.22020-08-26doi.org/10.1038/s41422-020-0384-8
7C2E (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-4.22020-08-26doi.org/10.1038/s41422-020-0384-8
7LLLB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ23.72022-01-12doi.org/10.1038/s41467-021-27760-0
7LLL (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-3.72022-01-12doi.org/10.1038/s41467-021-27760-0
7LLYB1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-Gs/β1/γ23.32022-01-12doi.org/10.1038/s41467-021-27760-0
7LLY (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-3.32022-01-12doi.org/10.1038/s41467-021-27760-0
7FIMB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-Gs/β1/γ23.42022-03-02doi.org/10.1038/s41467-022-28683-0
7FIM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-3.42022-03-02doi.org/10.1038/s41467-022-28683-0
7VBIB1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-Gs/β1/γ232022-03-02doi.org/10.1038/s41467-022-28683-0
7VBI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-32022-03-02doi.org/10.1038/s41467-022-28683-0
7VBHB1PeptideGlucagonGLP-1Homo sapiensPeptide-20-Gs/β1/γ232022-04-06doi.org/10.1038/s41467-022-28683-0
7VBH (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-20-32022-04-06doi.org/10.1038/s41467-022-28683-0
7S1MB1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-Gs/β1/γ22.412022-01-05doi.org/10.1038/s41589-021-00945-w
7S1M (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-2.412022-01-05doi.org/10.1038/s41589-021-00945-w
7S3IB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.512022-01-05doi.org/10.1038/s41589-021-00945-w
7S3I (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.512022-01-05doi.org/10.1038/s41589-021-00945-w
6XOXB1PeptideGlucagonGLP-1Homo sapiensOrforglipron-chim(NtGi1-Gs)/β1/γ23.12020-11-18doi.org/10.1073/pnas.2014879117
6XOX (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipron-3.12020-11-18doi.org/10.1073/pnas.2014879117
7RG9B1PeptideGlucagonGLP-1Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22022-04-13doi.org/10.1073/pnas.2116506119
7RG9 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.22022-04-13doi.org/10.1073/pnas.2116506119
7RGPB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-chim(NtGi1-Gs)/β1/γ22.92022-04-13doi.org/10.1073/pnas.2116506119
7RGP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-2.92022-04-13doi.org/10.1073/pnas.2116506119
7X8RB1PeptideGlucagonGLP-1Homo sapiensBOC5-Gs/β1/γ22.612022-06-29doi.org/10.1073/pnas.2200155119
7X8R (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensBOC5-2.612022-06-29doi.org/10.1073/pnas.2200155119
7X8SB1PeptideGlucagonGLP-1Homo sapiensWB4-24-Gs/β1/γ23.092022-06-29doi.org/10.1073/pnas.2200155119
7X8S (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensWB4-24-3.092022-06-29doi.org/10.1073/pnas.2200155119
8JIPB1PeptideGlucagonGLP-1Homo sapiensMEDI0382-chim(NtGi1-Gs)/β1/γ22.852023-09-06doi.org/10.1073/pnas.2303696120
8JIP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensMEDI0382-2.852023-09-06doi.org/10.1073/pnas.2303696120
8JIRB1PeptideGlucagonGLP-1Homo sapiensSAR425899-chim(NtGi1-Gs)/β1/γ22.572023-09-06doi.org/10.1073/pnas.2303696120
8JIR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSAR425899-2.572023-09-06doi.org/10.1073/pnas.2303696120
8JISB1PeptideGlucagonGLP-1Homo sapiensPeptide-15-chim(NtGi1-Gs)/β1/γ22.462023-11-08doi.org/10.1073/pnas.2303696120
8JIS (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-15-2.462023-11-08doi.org/10.1073/pnas.2303696120
8YW3B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-Gs/β1/γ22.682024-09-18doi.org/10.1038/s41421-024-00700-0
8YW3 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-2.682024-09-18doi.org/10.1038/s41421-024-00700-0
9EBNB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ23.442025-03-26doi.org/10.1073/pnas.2407574122
9EBN (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.442025-03-26doi.org/10.1073/pnas.2407574122
9EBOB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (ACPC18)-Gs/β1/γ23.132025-03-26doi.org/10.1073/pnas.2407574122
9EBO (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (ACPC18)-3.132025-03-26doi.org/10.1073/pnas.2407574122
9EBQB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ23.162025-03-26doi.org/10.1073/pnas.2407574122
9EBQ (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.162025-03-26doi.org/10.1073/pnas.2407574122
8YWFB1PeptideGlucagonGLP-1Homo sapiensRetatrutide-chim(NtGi1-Gs)/β1/γ22.742025-04-16To be published
8YWF (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-2.742025-04-16To be published
9BYOB1PeptideGlucagonGLP-1Homo sapiensExendin-3-Gs/β1/γ22.312025-06-11To be published
9BYO (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-3-2.312025-06-11To be published
9C0KB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ22.722025-06-11To be published
9C0K (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-2.722025-06-11To be published




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