Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:V170 3.53254268
2R:R:F176 5.496137
3R:R:W182 8.10833616
4R:R:Q189 5.6545134
5R:R:I205 3.545156
6R:R:Y209 7.59254268
7R:R:L213 3.813336136
8R:R:L229 4.095407
9R:R:Y230 6.818547
10R:R:Y234 6.45545
11R:R:I240 4.1925405
12R:R:I241 4.6385137
13R:R:P244 5.7675418
14R:R:S247 5.6425419
15R:R:V253 4.06417
16R:R:M259 3.9475445
17R:R:W260 6.38647
18R:R:I263 3.9406
19R:R:V264 3.0925419
20R:R:S266 5.1775418
21R:R:Y267 5.224297137
22R:R:S269 5.2418
23R:R:S271 4.0425419
24R:R:P272 5.055617
25R:R:L274 5.56833618
26R:R:R279 9.8075416
27R:R:F280 7.408518
28R:R:F283 5.402518
29R:R:R285 5.085419
30R:R:H287 7.38833617
31R:R:P288 5.9925416
32R:R:N294 6.745419
33R:R:T296 6.4775428
34R:R:R297 4.135417
35R:R:F301 6.62426
36R:R:W304 7.53143727
37R:R:W306 6.91729
38R:R:I312 4.28456
39R:R:Q313 3.1407
40R:R:V318 5.915415
41R:R:F319 5.57833617
42R:R:E327 2.50754165
43R:R:I335 3.27407
44R:R:I337 4.0025166
45R:R:F339 10.0825456
46R:R:R340 6.207147166
47R:R:Q341 6.504557
48R:R:S342 4.985407
49R:R:F343 8.7125457
50R:R:F344 5.14333684
51R:R:P347 8.47406
52R:R:V349 5.48403
53R:R:P350 5.1775457
54R:R:L354 2.75558
55R:R:I361 6.446529
56R:R:L365 3.2406
57R:R:R372 4.916517
58R:R:F375 8.1325408
59R:R:C376 3.845419
60R:R:Y379 6.088517
61R:R:F384 2.88415
62R:R:F391 6.006527
63R:R:W395 8.194515
64R:R:Y396 6.2425415
65R:R:W400 6.12857718
66R:R:F401 6.78517
67R:R:D405 6.74413
68R:R:I408 5.028513
69R:R:C410 3.7075419
70R:R:V419 5.735415
71R:R:H422 5.614516
72R:R:I423 5.185426
73R:R:T424 4.6075416
74R:R:I427 3.285415
75R:R:M429 5.965414
76R:R:N431 4.0225406
77R:R:F446 6.51407
78R:R:F464 6.095407
79R:R:E466 6.64515
80R:R:L469 3.878516
81R:R:Y471 5.822867159
82R:R:D472 5.6525409
83R:R:I474 4.91406
84R:R:L481 4.23408
85R:R:I505 3.45406
86R:R:Y510 6.085405
87R:R:M513 6.93254286
88R:R:F518 5.02833609
89R:R:F527 4.8454289
90R:R:L538 6.7975414
91R:R:E540 7.2525416
92R:R:Q541 6.506529
93R:R:L542 5.48514
94R:R:Y547 4.67167615
95R:R:I550 4.505627
96R:R:Y553 7.25626
97R:R:D554 12.34325
98R:R:W562 7.895625
99R:R:D566 6.9125425
100R:R:W568 5.66429729
101R:R:P573 6.2925425
102R:R:D576 4.185429
103R:R:R585 6.7925475
104R:R:L587 5.2275477
105R:R:Q589 6.945472
106R:R:F592 3.3375475
107R:R:N613 5.37254129
108R:R:N616 6.3585125
109R:R:Y621 7.96754124
110R:R:Q626 6.484149
111R:R:L629 5.21754146
112R:R:G636 2.7975409
113R:R:F645 5.33754335
114R:R:D650 4.6525479
115R:R:Y652 6.2474
116R:R:I654 3.852505
117R:R:F659 3.364354
118R:R:R666 3.6125408
119R:R:W668 7.3275406
120R:R:Y678 8.0854378
121R:R:S680 4.6325407
122R:R:M681 3.9145349
123R:R:F682 4.482509
124R:R:K684 6.1725409
125R:R:W687 6.846676149
126R:R:V688 4.64409
127R:R:F692 9.724388
128R:R:W708 5.334144
129R:R:L725 5.7925368
130R:R:W728 9.05754369
131R:R:D732 7.03408
132R:R:Q757 6.1675405
133R:R:W769 8.465408
134R:R:K777 8.4575409
135R:R:L781 5.0456378
136R:R:L787 4.6725409
137R:R:N800 5.2254129
138R:R:V805 4.9375409
139R:R:I809 5.0275408
140R:R:Y810 6.222599
141R:R:I818 3.725407
142R:R:Q830 5.1275475
143R:R:F834 5.125677
144R:R:F853 4.9075409
145R:R:K856 5.1485129
146R:R:L860 5.8285126
147S:S:M59 5.86833647
148S:S:L64 3.454175
149S:S:P79 3.064115
150S:S:L101 3.05405
151S:S:L103 2.7854171
152S:S:Y104 5.3525446
153S:S:F117 5.6375447
154S:S:Y118 7.38833647
155S:S:I121 5.222546
156S:S:P125 5.995447
157S:S:H127 5.788548
158S:S:M129 3.7885106
159S:S:F131 5.415107
160S:S:I142 3.4525407
161S:S:E144 8.36587
162S:S:W149 7.076547
163S:S:Q153 7.4525409
164S:S:L154 3.27407
165S:S:F156 4.6345106
166S:S:L163 6.45488
167S:S:Y169 7.0075487
168S:S:Y171 6.25254106
169S:S:F172 6.572588
170S:S:F173 7.39754107
171S:S:R174 6.575489
172S:S:V176 5.224226
173S:S:P177 4.2025226
174S:S:N183 5.59439
175S:S:L187 3.632535
176S:S:K188 4.2925435
177S:S:Y193 9.284538
178S:S:L201 4.055407
179S:S:Q203 6.598567
180S:S:F208 6.068567
181S:S:R212 7.972555
182S:S:L215 5.0475408
183S:S:L219 3.8475406
184S:S:E222 4.255435
185S:S:D228 6.566555
186S:S:T229 5.2025456
187S:S:E230 7.542558
188S:S:F232 6.985467
189S:S:P236 6.3475405
190S:S:L243 3.906558
191S:S:V248 4.305457
192S:S:R249 7.4485199
193S:S:F255 5.44568
194S:S:M259 6.465464
195S:S:A260 3.025468
196S:S:F264 4.395407
197S:S:Y268 9.4054426
198S:S:E270 5.04405
199S:S:M272 3.2775407
200S:S:Y273 4.69754425
201S:S:W284 7.3375466
202S:S:Y285 5.98833665
203S:S:W289 6.77667669
204S:S:W290 7.182566
205S:S:M311 5.23665
206S:S:Y314 7.46667605
207S:S:I315 3.7125435
208S:S:F319 6.8054224
209S:S:E320 7.414204
210S:S:T329 4.06507
211S:S:S331 4.794118
212S:S:T334 4.79254438
213S:S:Y338 7.7885117
214S:S:Y342 7.028336117
215S:S:K345 6.324113
216S:S:R346 6.55754114
217S:S:F354 5.64405
218S:S:H355 10.844117
219S:S:Y357 8.7554225
220S:S:Y359 7.853336119
221S:S:D360 6.5745119
222S:S:I362 4.8975406
223S:S:W363 6.854118
224S:S:V364 3.775407
225S:S:I365 4.785105
226S:S:L369 2.8054108
227S:S:F388 5.78407
228S:S:Y390 6.316548
229S:S:L400 4.72254103
230S:S:M403 5.0345105
231S:S:F408 6.8425409
232S:S:V411 6.08754117
233S:S:E421 5.2725487
234S:S:R422 5.05409
235S:S:K427 7.37754205
236S:S:F428 5.37538
237S:S:Q430 4.188539
238S:S:K438 4.524203
239S:S:Y442 4.778536
240S:S:L449 4.4475437
241S:S:F458 5.675439
242S:S:Y482 4.1854465
243S:S:M493 3.0525408
244S:S:I512 1.484218
245S:S:M519 4.44254486
246S:S:N520 5.495189
247S:S:I524 4.9225407
248S:S:G526 2.3975409
249S:S:Y531 6.874508
250S:S:D540 4.2954238
251S:S:R556 5.44254507
252S:S:F568 5.62408
253S:S:F572 4.4475409
254S:S:L597 7.25254488
255S:S:D608 5.415519
256S:S:L612 5.0425517
257S:S:D619 10.64249
258S:S:Y628 5.2254454
259S:S:R642 8.4125444
260S:S:P643 4.51404
261S:S:L644 5.5625404
262S:S:N650 6.5275408
263S:S:W656 12.76754248
264S:S:Y663 3.01405
265S:S:K664 6.5925409
266S:S:M668 4.2175408
267S:S:I683 4.042867477
268S:S:Y691 8.625496
269S:S:I692 3.5625408
270S:S:V696 2.716509
271S:S:Y697 6.078599
272S:S:N698 5.7175499
273S:S:V699 3.7125409
274S:S:M702 4.9075407
275S:S:F721 3.9825467
276S:S:F740 5.4945189
277S:S:L747 3.6445216
278L:L:?1 8.136361110
279W:W:?1 8.4541090
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:R202 R:R:W475 12.35043NoNo1558
2R:R:W475 R:R:Y471 13.05276.75NoYes1589
3R:R:A195 R:R:Y471 14.52894NoYes099
4R:R:A195 R:R:I474 14.95174.87NoYes096
5R:R:I474 R:R:M243 15.74032.92YesNo067
6R:R:M243 R:R:Y267 16.16334.79NoYes077
7R:R:P177 R:R:W182 10.01892.7NoYes076
8R:R:G268 R:R:Y267 18.62542.9NoYes077
9L:L:?1 R:R:W182 22.019417.25YesYes106
10L:L:?1 R:R:H287 30.08298.76YesYes107
11R:R:F446 R:R:V521 10.66275.24YesNo078
12R:R:D472 R:R:V521 14.13724.38YesNo098
13R:R:D472 R:R:S522 17.99867.36YesNo099
14R:R:L469 R:R:S522 20.18863YesNo069
15R:R:H287 R:R:L469 18.4575.14YesYes176
16R:R:E466 R:R:L469 18.60452.65YesYes156
17L:L:?1 R:R:E466 18.68966.02YesYes105
18S:S:F172 S:S:Q153 11.474710.54YesYes089
19R:R:L229 S:S:Y118 14.98333.52YesYes077
20R:R:L229 R:R:V253 26.90052.98YesYes077
21R:R:I241 R:R:L265 13.41444.28YesNo076
22R:R:P244 R:R:V253 24.29727.07YesYes187
23R:R:S247 R:R:S269 26.44024.89YesYes198
24R:R:S250 R:R:S269 12.97596.52NoYes188
25R:R:P244 R:R:S250 12.56567.13YesNo188
26R:R:S266 R:R:S269 12.98864.89YesYes188
27R:R:P244 R:R:S266 12.56675.34YesYes188
28R:R:S247 R:R:V318 17.21356.46YesYes195
29L:L:?1 R:R:F319 80.97183.69YesYes107
30R:R:F319 R:R:V318 16.7289.18YesYes175
31R:R:L274 R:R:S271 14.1224.5YesYes189
32R:R:M259 R:R:W260 11.00593.49YesYes457
33R:R:A473 R:R:T286 16.52253.36NoNo087
34R:R:L469 R:R:T286 16.81442.95YesNo067
35R:R:F319 R:R:L365 19.18153.65YesYes076
36R:R:F319 R:R:Q314 1003.51YesNo178
37R:R:E370 R:R:Q314 10012.74NoNo058
38R:R:E370 R:R:F343 1008.16NoYes057
39R:R:F343 R:R:I312 95.1195.02YesYes576
40R:R:I312 R:R:Q341 47.60312.74YesYes567
41R:R:F343 R:R:P350 48.19475.78YesYes577
42R:R:P350 R:R:Q341 49.83176.32YesYes577
43R:R:I312 R:R:L354 47.61014.28YesYes568
44R:R:F339 R:R:Q341 99.688412.88YesYes567
45R:R:F339 R:R:L354 47.723.65YesYes568
46R:R:F339 R:R:Q357 10019.91YesNo566
47R:R:F339 S:S:T229 10.43963.89YesYes566
48S:S:F172 S:S:R174 11.76934.28YesYes889
49S:S:R174 S:S:S178 12.03426.59YesNo898
50S:S:N180 S:S:S178 12.59925.96NoNo068
51R:R:Q357 S:S:E230 1003.82NoYes568
52S:S:D228 S:S:E230 1006.5YesYes558
53S:S:D228 S:S:S227 1002.94YesNo554
54S:S:R197 S:S:S227 10010.54NoNo064
55S:S:K467 S:S:R197 10011.14NoNo056
56S:S:K465 S:S:K467 1002.87NoNo045
57S:S:I469 S:S:K465 1007.27NoNo024
58S:S:I469 S:S:I639 1002.94NoNo024
59S:S:I639 S:S:L471 1001.43NoNo043
60S:S:I641 S:S:L471 1002.85NoNo053
61S:S:I641 S:S:P632 1001.69NoNo052
62S:S:P632 S:S:P643 1005.84NoYes024
63S:S:P643 S:S:R642 1002.88YesYes044
64S:S:E472 S:S:R642 98.88858.14NoYes014
65S:S:E472 S:S:L644 98.88336.63NoYes014
66S:S:L474 S:S:L644 98.86722.77NoYes034
67S:S:E646 S:S:L474 98.824110.6NoNo063
68S:S:E646 S:S:R623 1009.3NoNo066
69S:S:F549 S:S:R623 10010.69NoNo046
70S:S:C648 S:S:F549 1002.79NoNo094
71S:S:C553 S:S:C648 1007.28NoNo5099
72S:S:C553 S:S:L621 1003.17NoNo096
73S:S:L621 S:S:N650 1004.12NoYes068
74S:S:M653 S:S:N650 1005.61NoYes058
75S:S:F711 S:S:M653 1004.98NoNo055
76S:S:F711 S:S:L657 1008.53NoNo055
77S:S:L657 S:S:Y661 1007.03NoNo056
78S:S:K664 S:S:Y661 1005.97YesNo096
79S:S:K664 S:S:Y564 10011.94YesNo099
80S:S:F568 S:S:Y564 89.62148.25YesNo089
81S:S:F568 S:S:V699 89.13516.55YesYes089
82S:S:C731 S:S:V699 1003.42NoYes079
83S:S:C731 S:S:M702 1003.24NoYes077
84S:S:F730 S:S:M702 1007.46NoYes047
85S:S:F730 S:S:N698 95.87917.25NoYes949
86R:R:Y810 S:S:N698 94.78998.14YesYes999
87R:R:Y810 W:W:?1 77.99569.16YesYes990
88R:R:A788 W:W:?1 1003.08NoYes090
89R:R:A788 R:R:I809 1003.25NoYes098
90R:R:I809 R:R:M681 1007.29YesYes089
91R:R:M681 R:R:V805 75.66493.04YesYes099
92R:R:L852 R:R:V805 49.02242.98NoYes079
93R:R:F853 R:R:L852 97.14143.65YesNo097
94R:R:C609 R:R:F853 80.53698.38NoYes089
95R:R:C609 R:R:L605 79.66213.17NoNo084
96R:R:L605 R:R:L849 78.78722.77NoNo048
97R:R:C637 R:R:L849 74.41276.35NoNo058
98R:R:C637 R:R:S845 73.53773.44NoNo058
99R:R:L641 R:R:S845 72.66289.01NoNo088
100R:R:L641 R:R:S599 66.53787.51NoNo087
101R:R:F645 R:R:S599 63.91176.61YesNo3357
102R:R:F645 R:R:P646 62.16242.89YesNo056
103R:R:P646 R:R:R666 57.78672.88NoYes068
104R:R:L647 R:R:R666 48.15924.86NoYes058
105R:R:F834 R:R:L647 45.53332.44YesNo075
106R:R:F834 R:R:L587 35.90296.09YesYes777
107R:R:D650 R:R:L587 21.89464.07YesYes797
108R:R:D650 R:R:F586 20.14347.17YesNo794
109R:R:F584 R:R:F586 19.26854.29NoNo044
110R:R:F584 R:R:Q757 14.88978.2NoYes045
111R:R:K582 R:R:Q757 12.262610.85NoYes015
112R:R:K582 R:R:L755 11.38682.82NoNo014
113R:R:L755 R:R:V580 10.5112.98NoNo044
114S:S:K627 S:S:R642 98.888512.38NoYes034
115S:S:K627 S:S:L644 98.88339.87NoYes034
116S:S:L644 S:S:V625 98.86722.98YesNo044
117S:S:E646 S:S:V625 98.82412.85NoNo064
118S:S:M668 S:S:Y564 92.45525.99YesNo089
119S:S:M668 S:S:V699 89.26173.04YesYes089
120S:S:F730 S:S:I734 78.62528.79NoNo944
121S:S:I734 S:S:L738 78.40967.14NoNo947
122S:S:L738 W:W:?1 77.97542.7NoYes970
123R:R:M681 R:R:T848 49.42863.01YesNo3498
124R:R:L852 R:R:T848 48.99392.95NoNo078
125R:R:L587 R:R:Q830 10.51035.32YesYes775
126R:R:F853 R:R:N613 14.88614.83YesYes099
127R:R:K684 R:R:V805 25.83047.59YesYes099
128R:R:K684 R:R:N630 12.25715.6YesNo099
129R:R:I622 R:R:L860 15.75828.56NoYes1296
130R:R:L860 R:R:N616 10.50465.49YesYes1265
131R:R:I622 R:R:N613 11.38074.25NoYes1299
132R:R:M681 R:R:T633 13.13133.01YesNo097
133R:R:S680 R:R:T633 12.69286.4YesNo077
134R:R:I785 R:R:Y810 16.38624.84NoYes969
135R:R:A813 R:R:I785 16.17213.25NoNo076
136R:R:A813 R:R:L781 15.95584.73NoYes078
137R:R:I809 R:R:Y678 10.59536.04YesYes088
138R:R:F682 R:R:Y678 15.1027.22YesYes098
139R:R:F682 R:R:L783 11.16266.09YesNo097
140R:R:L783 R:R:L787 10.50552.77NoYes079
141S:S:D179 S:S:P161 10.05146.44NoNo076
142S:S:D179 S:S:T159 19.40028.67NoNo077
143S:S:T159 S:S:V176 19.30263.17NoYes076
144S:S:D179 S:S:R207 27.75125.96NoNo075
145S:S:L243 S:S:V248 19.95534.47YesYes587
146S:S:F208 S:S:R207 27.077313.9YesNo675
147S:S:F208 S:S:Q203 27.33514.68YesYes677
148S:S:F232 S:S:Q203 27.61828.2YesYes677
149S:S:L201 S:S:L243 33.0434.15YesYes078
150S:S:F232 S:S:L201 28.55716.09YesYes077
151S:S:C648 S:S:R556 10.05992.79NoYes5097
152S:S:L536 S:S:R556 10.42754.86NoYes067
153S:S:L536 S:S:L552 10.30958.3NoNo064
154S:S:L539 S:S:L552 10.19152.77NoNo054
155R:R:A473 R:R:L265 16.23123.15NoNo086
156R:R:L365 R:R:R297 13.19683.64YesYes067
157S:S:D228 S:S:L243 19.9155.43YesYes558
158S:S:S227 S:S:V248 19.99773.23NoYes547
159R:R:S271 R:R:V318 15.88684.85YesYes195
160R:R:Q314 R:R:T316 16.77074.25NoNo185
161R:R:T316 R:R:V318 16.63923.17NoYes155
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P177 R:R:W182 2.7 0 No Yes 7 6 2 1
R:R:G181 R:R:Y367 5.79 0 No No 5 7 2 1
R:R:P183 R:R:W182 4.05 0 No Yes 4 6 2 1
R:R:G184 R:R:W182 9.85 0 No Yes 5 6 2 1
R:R:G268 R:R:W182 2.81 0 No Yes 7 6 2 1
R:R:E466 R:R:W182 11.99 1 Yes Yes 5 6 1 1
L:L:?1 R:R:W182 17.25 1 Yes Yes 0 6 0 1
R:R:C220 R:R:C246 7.28 0 No No 8 7 2 1
R:R:S247 R:R:S269 4.89 1 Yes Yes 9 8 1 2
R:R:S247 R:R:S271 3.26 1 Yes Yes 9 9 1 2
R:R:S247 R:R:V318 6.46 1 Yes Yes 9 5 1 2
L:L:?1 R:R:S247 7.96 1 Yes Yes 0 9 0 1
R:R:G268 R:R:H287 4.77 0 No Yes 7 7 2 1
R:R:H287 R:R:S270 5.58 1 Yes No 7 7 1 1
R:R:A290 R:R:S270 3.42 1 No No 8 7 2 1
L:L:?1 R:R:S270 9.1 1 Yes No 0 7 0 1
R:R:S271 R:R:V318 4.85 1 Yes Yes 9 5 2 2
R:R:H287 R:R:P288 12.2 1 Yes Yes 7 6 1 2
R:R:H287 R:R:M429 7.88 1 Yes Yes 7 4 1 2
R:R:H287 R:R:L469 5.14 1 Yes Yes 7 6 1 2
L:L:?1 R:R:H287 8.76 1 Yes Yes 0 7 0 1
R:R:M429 R:R:P288 3.35 1 Yes Yes 4 6 2 2
R:R:Q314 R:R:T316 4.25 1 No No 8 5 2 2
R:R:F319 R:R:Q314 3.51 1 Yes No 7 8 1 2
R:R:T316 R:R:V318 3.17 1 No Yes 5 5 2 2
R:R:F319 R:R:T316 5.19 1 Yes No 7 5 1 2
R:R:F319 R:R:V318 9.18 1 Yes Yes 7 5 1 2
R:R:F319 R:R:L365 3.65 1 Yes Yes 7 6 1 2
R:R:F319 R:R:Y367 8.25 1 Yes No 7 7 1 1
L:L:?1 R:R:F319 3.69 1 Yes Yes 0 7 0 1
R:R:I393 R:R:L365 2.85 1 No Yes 5 6 1 2
L:L:?1 R:R:Y367 13.32 1 Yes No 0 7 0 1
R:R:E368 R:R:Y396 6.73 1 No Yes 7 5 2 1
R:R:E368 R:R:W400 6.54 1 No Yes 7 8 2 2
R:R:A371 R:R:Y396 4 1 No Yes 8 5 2 1
R:R:A371 R:R:W400 3.89 1 No Yes 8 8 2 2
R:R:I393 R:R:W395 4.7 1 No Yes 5 5 1 1
L:L:?1 R:R:I393 5.4 1 Yes No 0 5 0 1
R:R:E426 R:R:W395 7.63 1 No Yes 6 5 2 1
R:R:M429 R:R:W395 6.98 1 Yes Yes 4 5 2 1
R:R:E466 R:R:W395 8.72 1 Yes Yes 5 5 1 1
L:L:?1 R:R:W395 12.94 1 Yes Yes 0 5 0 1
R:R:W400 R:R:Y396 11.58 1 Yes Yes 8 5 2 1
L:L:?1 R:R:Y396 2.66 1 Yes Yes 0 5 0 1
R:R:L469 R:R:M429 5.65 1 Yes Yes 6 4 2 2
R:R:E466 R:R:Q465 3.82 1 Yes No 5 4 1 2
R:R:E466 R:R:L469 2.65 1 Yes Yes 5 6 1 2
L:L:?1 R:R:E466 6.02 1 Yes Yes 0 5 0 1
L:L:?1 R:R:C246 2.4 1 Yes No 0 7 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
100.00Single6D35Cholesterol6D35-SMO-Cholesterol
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
100.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
100.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
100.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
100.00Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00Single7FIIhCG7FII-LH-hCG-6fuf
100.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
100.00Single7XW7K1-707XW7-TSH-K1-70
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
100.00Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
100.00Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
100.00Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
100.00Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
100.00Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
100.00Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
100.00Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
100.00Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusgphr_onOrthosteric Ligandlh_on tsh_on
100.00Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00Consensusgs_proteinOrthosteric Ligandgs_gphr
100.00Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
100.00Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
100.00Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
100.00Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
100.00Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
100.00Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
100.00Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
100.00Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
100.00Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
100.00Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
100.00Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
33.33Single8HS2Fab0468HS2-GPR20-Fab046
25.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
25.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
25.00Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
25.00Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
20.00Single5L7DCholesterol5L7D-SMO-Cholesterol
20.00Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
20.00Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
20.00Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
14.29Single4XNWMRS25004XNW-P2Y1-MRS2500
14.29Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
14.29Single6LI0GTPL98046LI0-GPR52-GTPL9804
14.29Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
14.29Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
14.29Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
12.50Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
12.50Single4O9RCyclopamine4O9R-SMO-Cyclopamine
12.50Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.50Consensusgo_proteinOrthosteric Ligandgo_chemokine
12.50Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11Single4BWBNeurotensin4BWB-NTS1-Neurotensin
11.11Single4QINSAG1.54QIN-SMO-SAG1.5
11.11Single5U09Taranabant5U09-CB1-Taranabant
11.11Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.11Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.11Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
11.11Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.11Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.11Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
11.11Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
11.11Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11Consensusclass-f_offOrthosteric Ligandsmo_off
11.11Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
11.11Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.11Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
10.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
10.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
10.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.00Single7VV6C48/807VV6-MRGPRX2-C48/80
10.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
10.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
10.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
10.00Consensusgi_class-fOrthosteric Ligandgi_frizzled
10.00Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Consensusgnrh_offOrthosteric Ligandgnrh1_off
10.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
10.00Consensuss1p_offOrthosteric Ligands1p1_off
9.09Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
9.09Single5T04Neurotensin5T04-NTS1-Neurotensin
9.09Single5TGZAM65385TGZ-CB1-AM6538
9.09Single6D27CAY104716D27-DP2-CAY10471
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.09Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.09Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.09Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.09Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
9.09Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
9.09Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
9.09Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
9.09Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.09Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
9.09Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
9.09Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.33Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
8.33Single5C1MBU725C1M-μ-BU72
8.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.33Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.33Single7C4SS1P7C4S-S1P3-S1P
8.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
8.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
8.33Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
8.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
8.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
8.33Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
8.33Single7YXAONO-54306087YXA-S1P5-ONO-5430608
8.33Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
8.33Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.69Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
7.69Single4BV0Neurotensin4BV0-NTS1-Neurotensin
7.69Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
7.69Single5V56TC1145V56-SMO-TC114
7.69Single5V57TC1145V57-SMO-TC114
7.69Single6OS1TRV0266OS1-AT1-TRV026
7.69Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
7.69Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
7.69Single7F1TMIP-1a7F1T-CCR5-MIP-1a
7.69Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
7.69Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.69Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.69Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
7.69Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
7.69Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
7.69Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
7.69Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
7.69Single8E0GBU728E0G-μ-BU72
7.69Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
7.69Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
7.69Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
7.69Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
7.69Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
7.69Consensuslpa_offOrthosteric Ligandlpa1_off
7.69Consensuslpa_onOrthosteric Ligandlpa1_on
7.69Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
7.69Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
7.14Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
7.14Single4XEENeurotensin4XEE-NTS1-Neurotensin
7.14Single4XESNeurotensin4XES-NTS1-Neurotensin
7.14Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
7.14Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
7.14Single6OS2TRV0266OS2-AT1-TRV026
7.14Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
7.14Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single6YVRNTS8-136YVR-NTS1-NTS8-13
7.14Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
7.14Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
7.14Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
7.14Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
7.14Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.14Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
7.14Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
7.14Consensuschemokine_offOrthosteric Ligandcxcr_off
7.14Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
7.14Consensuscxcr_offOrthosteric Ligandcxcr4_off
7.14Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
7.14Consensusdp_offOrthosteric Liganddp2_off
7.14Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
7.14Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
7.14Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
7.14Consensusnts_onOrthosteric Ligandnts1_on
7.14Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
7.14Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
6.67Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
6.67Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
6.67Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
6.67Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
6.67Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
6.67Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
6.67Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6.67Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
6.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
6.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
6.67Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.67Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.67Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
6.67Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
6.25Single6KNMJN241-96KNM-Apelin-JN241-9
6.25Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
6.25Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
6.25Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
6.25Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
6.25Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
6.25Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
6.25Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
6.25Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25Consensuslpl_offOrthosteric Ligands1p_off lpa_off
6.25Consensuslpl_onOrthosteric Ligands1p_on lpa_on
6.25Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
6.25Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
5.88Single4XT1Fractalkine4XT1-US28-Fractalkine
5.88Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.88Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.88Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
5.88Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
5.88Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
5.88Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.88Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
5.88Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.88Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.88Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.88Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
5.88Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.88Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.88Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.88Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
5.88Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
5.56Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
5.56Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.56Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
5.56Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
5.56Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
5.56Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
5.56Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
5.56Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.56Single7SK5CXCL127SK5-ACKR3-CXCL12
5.56Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.56Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.56Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
5.56Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
5.26Single3OE0CVX153OE0-CXCR4-CVX15
5.26Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
5.26Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
5.26Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
5.26Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
5.26Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.26Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
5.26Consensusangiotensin_onOrthosteric Ligandat1_on
5.26Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
5.26Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
5.26Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
5.26Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
5.26Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
5.26Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
5.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
5.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
5.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
5.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
5.00Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
5.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
5.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
5.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
5.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
5.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
5.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
5.00Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
5.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
5.00Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.00Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
5.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
5.00Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
5.00Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.76Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.76Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
4.76Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
4.76Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.76Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.76Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.76Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.76Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
4.76Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.76Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.76Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
4.76Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
4.76Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.76Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
4.76Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
4.55Single4XT3Fractalkine4XT3-US28-Fractalkine
4.55Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
4.55Single6FJ3PTH6FJ3-PTH1-PTH
4.55Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.55Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.55Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single7SK3CXCL127SK3-ACKR3-CXCL12
4.55Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
4.55Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
4.55Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.55Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
4.55Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
4.55Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.55Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.55Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
4.55Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.55Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.35Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
4.35Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
4.35Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
4.35Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.35Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
4.35Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
4.35Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
4.35Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.35Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.35Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
4.35Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
4.35Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.35Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
4.35Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
4.35Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.35Consensusgo_class-b1Orthosteric Ligandgo_crf
4.35Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.35Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.17Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
4.17Single6LMLGlucagon6LML-Glucagon-Glucagon
4.17Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.17Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
4.17Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.17Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
4.17Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.17Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
4.17Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
4.17Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
4.17Single8IY6Endothelin-18IY6-ETB-Endothelin-1
4.17Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
4.17Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
4.17Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.17Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.17Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
4.17Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
4.17Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
4.17Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
4.17Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
4.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
4.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
4.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.00Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
4.00Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.00Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
4.00Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
4.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.00Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
4.00Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.00Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
3.85Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.85Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
3.85Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.85Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.85Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.85Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.85Consensusglp_onOrthosteric Ligandglp1_on glp2_on
3.85Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
3.70Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
3.70Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.70Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.70Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.70Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.70Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
3.57Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.57Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.57Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.57Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.57Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.57Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.57Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
3.57Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.57Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
3.57Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.45Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.45Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.45Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
3.45Consensuspth_onOrthosteric Ligandpth1_on pth2_on
3.33Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.33Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.23Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.23Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
3.23Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.12Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
3.12Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
3.12Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.03Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
3.03Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
3.03Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.94Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.94Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.86Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I785 R:R:Y810 4.84 9 No Yes 6 9 1 1
R:R:A813 R:R:I785 3.25 0 No No 7 6 2 1
R:R:I785 W:W:?1 2.79 9 No Yes 6 0 1 0
R:R:A788 R:R:I809 3.25 0 No Yes 9 8 1 2
R:R:A788 W:W:?1 3.08 0 No Yes 9 0 1 0
R:R:K792 R:R:Y789 10.75 9 No No 9 8 1 1
R:R:Y789 W:W:?1 24.06 9 No Yes 8 0 1 0
R:R:K792 W:W:?1 9.65 9 No Yes 9 0 1 0
R:R:Y810 S:S:M694 5.99 9 Yes No 9 6 1 1
R:R:Y810 S:S:Y697 2.98 9 Yes Yes 9 9 1 2
R:R:Y810 S:S:N698 8.14 9 Yes Yes 9 9 1 2
R:R:Y810 W:W:?1 9.16 9 Yes Yes 9 0 1 0
S:S:D688 S:S:Y691 5.75 0 No Yes 9 6 2 1
S:S:K690 S:S:Y691 10.75 9 No Yes 8 6 1 1
S:S:K690 W:W:?1 9.65 9 No Yes 8 0 1 0
S:S:P742 S:S:Y691 11.13 0 No Yes 9 6 2 1
S:S:Y691 W:W:?1 6.87 9 Yes Yes 6 0 1 0
S:S:L738 S:S:M694 2.83 9 No No 7 6 1 1
S:S:M694 W:W:?1 15.2 9 No Yes 6 0 1 0
S:S:N698 S:S:Y697 4.65 9 Yes Yes 9 9 2 2
S:S:I734 S:S:N698 2.83 9 No Yes 4 9 2 2
S:S:I734 S:S:L738 7.14 9 No No 4 7 2 1
S:S:L738 W:W:?1 2.7 9 No Yes 7 0 1 0
R:R:M807 W:W:?1 1.38 0 No Yes 7 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
88.89Single7CA3rac-BHFF7CA3-GABAB1, GABAB2-rac-BHFF
66.67Single7EB2rac-BHFF7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
66.67Consensusclass-c_onOther Ligandgabab_on mglu_on
66.67Consensusgabab_onOther Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
66.67Consensusgi_class-cOther Ligandgi_mglu gi_gaba
60.00Consensusgi_gabaOther Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
50.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
36.84Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
35.29Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
35.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
31.58Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
30.00Single6UO8GS397836UO8-GABAB1, GABAB2-SKF97541-GS39783
29.41Single6LN2PubChem 681786306LN2-GLP-1-PubChem 68178630
26.67Single5VEWPF-063722225VEW-GLP-1-PF-06372222
25.00Single5XEZNNC06405XEZ-Glucagon-NNC0640
23.53Single5XF1NNC06405XF1-Glucagon-NNC0640
23.53Consensusffa3_on_alloOther Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
22.22Single8J20AR4206268J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
21.43Single5VEXNNC06405VEX-GLP-1-NNC0640
21.43Single6KK7PubChem 681786306KK7-GLP-1-PubChem 68178630
21.05Single8TB7PubChem 1685102188TB7-GPR61-PubChem 168510218
20.00Single6KJVPubChem 681786306KJV-GLP-1-PubChem 68178630
20.00Single8HNNSCH5467388HNN-CXCR3-SCH546738
17.65Single7RBTPubChem 1631837747RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single6KK1PubChem 681786306KK1-GLP-1-PubChem 68178630
11.76Single7EJX(1R;2R)-2-PCCA7EJX-GPR88-(1R;2R)-2-PCCA-Gi1/&β;1/&γ;2
11.11Single8GTIBMK-C2058GTI-CRF1-BMK-C205
10.53Single8GTGBMK-I1528GTG-CRF1-BMK-I152
9.52Single8GTMBMK-C2038GTM-CRF1-BMK-C203
8.33Single7DUQPubChem 1560227387DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
6.67Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
5.88Single4K5YCP-3763954K5Y-CRF1-CP-376395
5.56Single5X7DPubChem 1293189635X7D-β2-(S)-Carazolol-PubChem 129318963
5.26Single4Z9GCP-3763954Z9G-CRF1-CP-376395
5.26Single8JPFPubChem 1186104278JPF-NTS1-Neurotensin-PubChem 118610427
5.26Single8JR9PCO3718JR9-PTH1-PCO371-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single6LFLPubChem 1534669966LFL-CXCR2-PubChem 153466996
5.00Single8GW8KHF8GW8-PTH1-KHF-Gs/&β;1/&γ;2
4.55Single5LWEVercirnon5LWE-CCR9-Vercirnon
4.55Consensusccr9_off_alloOther Ligand5LWE-CCR9-Vercirnon
3.12Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
3.12Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
3.03Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
3.03Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
3.03Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
3.03Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
3.03Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
2.94Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.86Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.78Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.78Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.63Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.50Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.44Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.44Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
2.44Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.33Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 7C7Q
Class C
SubFamily Aminoacid
Type GABAB
SubType GABAB1; GABAB2
Species Homo sapiens
Ligand Baclofen
Other Ligand(s) PubChem 7023848
Protein Partners -
PDB Resolution 3
Date 2020-07-01
D.O.I. 10.1038/s41422-020-0350-5
Net Summary
Imin 2.64
Number of Linked Nodes 1293
Number of Links 1631
Number of Hubs 279
Number of Links mediated by Hubs 987
Number of Communities 51
Number of Nodes involved in Communities 407
Number of Links involved in Communities 565
Path Summary
Number Of Nodes in MetaPath 162
Number Of Links MetaPath 161
Number of Shortest Paths 35356736
Length Of Smallest Path 3
Average Path Length 116.915
Length of Longest Path 94
Minimum Path Strength 1.21
Average Path Strength 8.00568
Maximum Path Strength 25.645
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.22222
Average % Of Corr. Nodes 81.5449
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 64.5644
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code2C0
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
Code2C0
NameArbaclofen
Synonyms(3R)-4-amino-3-(4-chlorophenyl)butanoic acid
Identifier(3R)-4-azanyl-3-(4-chlorophenyl)butanoic acid
FormulaC10 H12 Cl N O2
Molecular Weight213.661
SMILESc1cc(ccc1[C@@H](CC(=O)O)CN)Cl
PubChem44602
Formal Charge0
Total Atoms26
Total Chiral Atoms1
Total Bonds26
Total Aromatic Bonds6

CodeFN0
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeFN0
Name(3S)-5,7-ditert-butyl-3-oxidanyl-3-(trifluoromethyl)-1-benzofuran-2-one
Synonyms
Identifier(3~{S})-5,7-di~{tert}-butyl-3-oxidanyl-3-(trifluoromethyl)-1-benzofuran-2-one
FormulaC17 H21 F3 O3
Molecular Weight330.342
SMILESCC(C)(C)c1cc2c(c(c1)C(C)(C)C)OC(=O)[C@@]2(C(F)(F)F)O
PubChem7023848
Formal Charge0
Total Atoms44
Total Chiral Atoms1
Total Bonds45
Total Aromatic Bonds6

CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3 H:H:?4 H:H:?5 H:H:?6 H:H:?7 H:H:?8
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetyl-D-glucosamine
IdentifierN-[(2R,3R,4R,5S,6R)-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl]ethanamide
FormulaC8 H15 N O6
Molecular Weight221.208
SMILESCC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ9UBS5
Sequence
>7C7Q_Chain_R
ERRAVYIGA LFPMSGGWP GGQACQPAV EMALEDVNS RRDILPDYE 
LKLIHHDSK CDPGQATKY LYELLYNDP IKIILMPGC SSVSTLVAE 
AARMWNLIV LSYGSSSPA LSNRQRFPT FFRTHPSAT LHNPTRVKL 
FEKWGWKKI ATIQQTTEV FTSTLDDLE ERVKEAGIE ITFRQSFFS 
DPAVPVKNL KRQDARIIV GLFYETEAR KVFCEVYKE RLFGKKYVW 
FLIGWYADN WFKIYDPSI NCTVDEMTE AVEGHITTE IVMLNPANT 
RSISNMTSQ EFVEKLTKR LKRHPEETG GFQEAPLAY DAIWALALA 
LNKTSRLED FNYNNQTIT DQIYRAMNS SSFEGVSGH VVFDASGSR 
MAWTLIEQL QGGSYKKIG YYDSTKDDL SWSKTDKWI GGSPPADQT 
LVIKTFRFL SQKLFISVS VLSSLGIVL AVVCLSFNI YNSHVRYIQ 
NSQPNLNNL TAVGCSLAL AAVFPLGLD GYHIGRNQF PFVCQARLW 
LLGLGFSLG YGSMFTKIW WVHTVFTLE PWKLYATVG LLVGMDVLT 
LAIWQIVDP LHRTIETFA KEEPKEDID VSILPQLEH CSSRKMNTW 
LGIFYGYKG LLLLLGIFL AYETKSVST EKINDHRAV GMAIYNVAV 
LCLITAPVT MILSSQQDA AFAFASLAI VFSSYITLV VLFVPKMRR 
LIT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtO75899
Sequence
>7C7Q_Chain_S
PPLSIMGLM PLTKEVAKG SIGRGVLPA VELAIEQIR NESLLRPYF 
LDLRLYDTE CDNAKGLKA FYDAIKYGP NHLMVFGGV CPSVTSIIA 
ESLQGWNLV QLSFAATTP VLADKKKYP YFFRTVPSD NAVNPAILK 
LLKHYQWKR VGTLTQDVQ RFSEVRNDL TGVLYGEDI EISDTESFS 
NDPCTSVKK LKGNDVRII LGQFDQNMA AKVFCCAYE ENMYGSKYQ 
WIIPGWYEP SWWEQVHRC LRKNLLAAM EGYIGVDFE PLSSKQIKT 
ISGKTPQQY EREYNNKRS GVGPSKFHG YAYDGIWVI AKTLQRAME 
TLIQDFNYT DHTLGRIIL NAMNETNFF GVTGQVVFR NGERMGTIK 
FTQFQDSRE VKVGEYNAV ADTLEIIND TIRFQGSEP PKDKTIILE 
QLRKISLPL YSILSALTI LGMIMASAF LFFNIKNRN QKLIKMSSP 
YMNNLIILG GMLSYASIF LFGLDGSFV SEKTFETLC TVRTWILTV 
GYTTAFGAM FAKTWRVHA IFKQKLLVI VGGMLLIDL CILICWQAV 
DPLRRTVEK YSMEPDPAG RDISIRPLL EHCENTHMT IWLGIVYAY 
KGLLMLFGC FLAWETRNV SIPALNDSK YIGMSVYNV GIMCIIGAA 
VSFLTRDQP NVQFCIVAL VIIFCSTIT LCLVFVPKL ITLR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6W2YCAminoacidGABABGABAB1; GABAB1Homo sapiensPubChem 5311042PubChem 23727970-3.22020-07-0110.1038/s41586-020-2469-4
6UO8CAminoacidGABABGABAB1, GABAB2Homo sapiensSKF97541GS39783-3.632020-06-1010.1038/s41586-020-2408-4
6UO9CAminoacidGABABGABAB1, GABAB2Homo sapiensSKF97541--4.82020-06-1010.1038/s41586-020-2408-4
6UOACAminoacidGABABGABAB1, GABAB2Homo sapiens---6.32020-06-1010.1038/s41586-020-2408-4
6VJMCAminoacidGABABGABAB1, GABAB2Homo sapiens---3.972020-06-1010.1038/s41586-020-2408-4
6W2XCAminoacidGABABGABAB1, GABAB2Homo sapiensPubChem 5311042PubChem 23727970-3.62020-07-0110.1038/s41586-020-2469-4
6WIVCAminoacidGABABGABAB1, GABAB2Homo sapiens-PubChem 52923113; PubChem 52924645-3.32020-07-0110.1038/s41586-020-2452-0
7C7SCAminoacidGABABGABAB1, GABAB2Homo sapiensCGP54626--2.92020-07-0110.1038/s41422-020-0350-5
7CA3CAminoacidGABABGABAB1, GABAB2Homo sapiens-rac-BHFF-4.52020-11-1110.1016/j.jmb.2020.09.023
7CA5CAminoacidGABABGABAB1, GABAB2Homo sapiens---7.62020-11-1110.1016/j.jmb.2020.09.023
7CUMCAminoacidGABABGABAB1, GABAB2Homo sapiensCGP54626Phospholipid-3.522020-11-1110.1016/j.jmb.2020.09.023
7EB2CAminoacidGABABGABAB1, GABAB2Homo sapiensBaclofenrac-BHFFGi1/&β;1/&γ;23.52021-05-0510.1038/s41586-021-03507-1




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Download 7C7Q.zip



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