Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:W39 6.27667655
2R:R:R40 5.268552
3R:R:Y42 7.34556
4R:R:R43 5.4025454
5R:R:D53 3.7775403
6R:R:P56 6.66754201
7R:R:F61 7.75754203
8R:R:F66 5.6457
9R:R:Y69 5.74667656
10R:R:C71 4.6225459
11R:R:W72 6.6185149
12R:R:P86 7.4275458
13R:R:Y88 8.09655
14R:R:L89 5.10857755
15R:R:P90 6.6025454
16R:R:W91 9.682554
17R:R:H99 5.77404
18R:R:R102 9.8765148
19R:R:W110 9.1185149
20R:R:Y145 8.525425
21R:R:Y148 6.6825827
22R:R:Y152 7.51714727
23R:R:L159 4.118529
24R:R:L166 5.7975408
25R:R:F169 9.14157
26R:R:R176 6.162867119
27R:R:N177 5.7454119
28R:R:H180 5.565119
29R:R:L183 6.335409
30R:R:F184 4.712508
31R:R:F187 9.18528
32R:R:R190 10.89628
33R:R:K197 8.088526
34R:R:L201 4.1325407
35R:R:M204 7.654123
36R:R:Y205 7.753336123
37R:R:W214 12.216551
38R:R:Y220 6.03403
39R:R:Q221 7.77254124
40R:R:F230 5.7125405
41R:R:Q234 9.8375427
42R:R:Y235 4.33409
43R:R:Y241 9.404528
44R:R:W243 13.5625229
45R:R:V246 4.6275408
46R:R:E247 9.77754119
47R:R:Y250 6.8645118
48R:R:L255 3.785408
49R:R:W264 5.6775405
50R:R:Y269 4.666507
51R:R:W274 8.5485229
52R:R:W284 9.175628
53R:R:E292 8.7975406
54R:R:W297 9.09167628
55R:R:R299 6.166124
56R:R:Y305 9.4075404
57R:R:W306 13.4183626
58R:R:R310 12.058526
59R:R:I317 4.2725427
60R:R:K334 8.42254239
61R:R:H363 7.04528
62R:R:E364 7.43528
63R:R:F367 6.6507
64R:R:M371 4.285427
65R:R:E373 9.5675424
66R:R:R380 6.93405
67R:R:T391 5.46426
68R:R:Q394 7.468529
69R:R:C403 4.4685159
70R:R:F404 3.975408
71R:R:V409 4.83754159
72R:R:E412 10.10254158
73L:L:H1 7.36286720
74L:L:D3 7.2025420
75L:L:F6 6.7475420
76L:L:S11 5.33754120
77L:L:F22 6.95143750
78A:A:E16 6.805434
79A:A:Q19 11.185434
80A:A:K53 5.88667699
81A:A:I56 4.1875497
82A:A:F212 7.35254249
83A:A:F219 7.90833608
84A:A:M221 4.51408
85A:A:F222 13.325417
86A:A:Q227 6.2725419
87A:A:K233 6.09619
88A:A:W234 8.575419
89A:A:C237 4.91418
90A:A:F238 10.71419
91A:A:F246 4.956549
92A:A:V247 5.012597
93A:A:Y253 7.9225198
94A:A:N264 6.42409
95A:A:F273 5.57649
96A:A:W277 9.68667646
97A:A:W281 14.135615
98A:A:L289 5.926549
99A:A:F290 8.30167699
100A:A:N292 4.492599
101A:A:Q294 7.375446
102A:A:L296 4.525406
103A:A:K300 5.874199
104A:A:F312 5.4525448
105A:A:F315 11.222546
106A:A:Y318 6.98546
107A:A:P321 4.40167645
108A:A:E330 9.8575443
109A:A:V334 4.1925404
110A:A:K338 10.312545
111A:A:Y339 8.13543
112A:A:F340 11.95547
113A:A:R342 6.098544
114A:A:E344 9.19445
115A:A:F345 9.018548
116A:A:R356 9.28402
117A:A:Y358 8.176504
118A:A:Y360 10.7725408
119A:A:F363 10.622545
120A:A:T364 8.7975499
121A:A:N371 8.218599
122A:A:R373 6.9065175
123A:A:R374 8.756594
124A:A:F376 6.1456178
125A:A:D381 8.32754238
126A:A:R385 8.6985235
127A:A:Y391 9.314114
128B:B:L4 4.39504
129B:B:L14 4.47408
130B:B:I18 3.5875407
131B:B:I37 4.965402
132B:B:H54 9.658539
133B:B:L55 6.5125436
134B:B:K57 14.052519
135B:B:Y59 8.58518
136B:B:M61 4.3475436
137B:B:W63 8.804537
138B:B:V71 3.9425408
139B:B:Q75 8.63419
140B:B:D76 7.23539
141B:B:K78 4.37508
142B:B:L79 6.264107
143B:B:I81 5.64254107
144B:B:W82 10.4333639
145B:B:D83 11.675438
146B:B:T86 9.35436
147B:B:N88 9.84437
148B:B:K89 6.235639
149B:B:I93 5.4054107
150B:B:L95 5.1945108
151B:B:R96 6.79754106
152B:B:W99 9.34667619
153B:B:M101 5.8175419
154B:B:Y105 5.3825406
155B:B:N110 6.93754134
156B:B:Y111 6.3545134
157B:B:V112 4.53408
158B:B:L117 4.64519
159B:B:C121 4.135418
160B:B:I123 3.826676136
161B:B:Y124 5.2658106
162B:B:H142 8.076519
163B:B:Y145 7.095818
164B:B:F151 5.975609
165B:B:I157 6.0375407
166B:B:T159 6.0875419
167B:B:S160 5.1725476
168B:B:D163 7.724519
169B:B:L168 4.655476
170B:B:W169 10.125618
171B:B:Q176 7.175414
172B:B:F180 8.632577
173B:B:H183 10.458579
174B:B:D186 6.23419
175B:B:L190 5.96475
176B:B:F199 10.8575479
177B:B:V200 7.2425466
178B:B:S201 5.2625479
179B:B:C204 4.965617
180B:B:D205 8.0175479
181B:B:K209 9.898576
182B:B:L210 4.87405
183B:B:W211 9.904578
184B:B:Q220 8.55467
185B:B:H225 10.3933669
186B:B:D228 8.746519
187B:B:I232 5.09468
188B:B:F235 7.911676166
189B:B:N237 9.724165
190B:B:F241 7.848566
191B:B:T243 5.8975468
192B:B:D246 7.2175419
193B:B:D247 8.94569
194B:B:T249 8.2175466
195B:B:R251 12.665668
196B:B:F253 7.10333666
197B:B:D254 5.0775409
198B:B:D258 10.32467
199B:B:E260 8.5725466
200B:B:T263 7.3461
201B:B:Y264 7.96505
202B:B:C271 3.83415
203B:B:I273 6.355416
204B:B:F278 6.94254167
205B:B:R283 7.476676189
206B:B:L284 5.83254255
207B:B:L285 5.0825406
208B:B:Y289 7.57429717
209B:B:D290 7.37416
210B:B:C294 5.09485
211B:B:N295 9.0375416
212B:B:W297 8.4125418
213B:B:K301 4.97405
214B:B:R304 7.6125415
215B:B:H311 11.478589
216B:B:R314 16.586518
217B:B:V327 3.7975406
218B:B:T329 6.4475488
219B:B:W332 12.9314719
220B:B:D333 9.73489
221B:B:F335 7.3525484
222B:B:K337 8.38167686
223B:B:W339 11.694589
224G:G:R27 7.09568
225G:G:L37 4.35754167
226G:G:Y40 12.124166
227G:G:D48 6.956509
228G:G:L51 4.04506
229G:G:N59 6.98167639
230G:G:F61 6.13375838
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:F22 R:R:L32 78.02893.65YesNo504
2L:L:F22 L:L:I23 19.5983.77YesNo500
3L:L:I23 R:R:L89 16.23115.71NoYes505
4R:R:L32 R:R:Q213 83.53247.99NoNo044
5R:R:W39 R:R:Y88 21.444213.5YesYes555
6R:R:Y42 R:R:Y88 14.108911.91YesYes565
7R:R:R43 R:R:W39 10.72085YesYes545
8L:L:L26 R:R:Y88 21.43593.52NoYes505
9R:R:L50 R:R:R64 17.17752.43NoNo044
10R:R:C71 R:R:L50 13.80861.59YesNo594
11R:R:R102 R:R:W120 15.642413YesNo085
12R:R:D122 R:R:W120 19.32197.82NoNo075
13R:R:D122 R:R:Y101 20.24088.05NoNo2175
14R:R:H99 R:R:Y101 23.92054.36YesNo045
15R:R:G98 R:R:H99 26.67943.18NoYes044
16R:R:C85 R:R:G98 27.5993.92NoNo094
17R:R:C126 R:R:C85 32.19657.28NoNo099
18R:R:C126 R:R:Y69 35.87262.69NoYes096
19R:R:L89 R:R:Y69 13.78935.86YesYes556
20R:R:K197 R:R:Y148 88.81613.58YesYes267
21R:R:F230 R:R:K197 59.27324.96YesYes056
22R:R:F230 R:R:L201 29.50664.87YesYes057
23L:L:S11 R:R:L201 29.4053YesYes007
24L:L:S11 R:R:Y205 43.95985.09YesYes1203
25R:R:Q221 R:R:Y205 85.2895.64YesYes1243
26R:R:Q213 R:R:Q221 84.741411.52NoYes044
27L:L:T7 R:R:K197 29.534815.02NoYes206
28L:L:T7 R:R:L201 29.49914.42NoYes007
29R:R:F230 R:R:T298 29.65947.78YesNo055
30L:L:S11 R:R:T298 14.70587.99YesNo1205
31L:L:M14 R:R:L201 29.50654.24NoYes007
32L:L:M14 R:R:Y205 29.311411.97NoYes003
33R:R:R299 R:R:T298 14.91133.88YesNo1245
34R:R:R299 R:R:Y205 15.06413.09YesYes1243
35R:R:Y148 R:R:Y152 89.83435.96YesYes277
36R:R:R190 R:R:Y152 89.95978.23YesYes287
37R:R:N240 R:R:R190 98.45210.85NoYes098
38R:R:N240 R:R:S186 92.33448.94NoNo099
39R:R:V246 R:R:W243 89.78268.58YesYes089
40R:R:S186 R:R:W243 89.58137.41NoYes099
41R:R:H180 R:R:R176 12.50015.64YesYes1199
42R:R:V246 R:R:Y269 90.61623.79YesYes087
43R:R:Y250 R:R:Y269 90.80985.96YesYes087
44A:A:Y391 R:R:R176 10.071312.35YesYes1149
45R:R:L254 R:R:Y250 94.562414.07NoYes1188
46A:A:H387 R:R:L254 99.975423.14NoNo088
47A:A:F219 A:A:H41 99.99386.79YesNo086
48A:A:H41 A:A:I383 1006.63NoNo068
49A:A:H387 A:A:I383 99.98733.98NoNo088
50B:B:M61 B:B:W63 10.19195.82YesYes367
51B:B:C317 B:B:M61 10.62024.86NoYes076
52B:B:C317 B:B:S316 10.90613.44NoNo079
53B:B:S316 B:B:W332 24.23933.71NoYes099
54B:B:W332 B:B:Y59 45.31589.65YesYes198
55A:A:C237 B:B:Y59 21.10665.38YesYes188
56A:A:C237 B:B:L117 21.45046.35YesYes189
57A:A:Q227 B:B:L117 22.72033.99YesYes199
58A:A:Q227 B:B:N119 46.98026.6YesNo099
59A:A:G206 B:B:N119 93.5525.09NoNo089
60A:A:A226 A:A:G206 93.59571.95NoNo098
61A:A:A226 A:A:G225 93.63961.95NoNo099
62A:A:F208 A:A:G225 93.68383.01NoNo059
63A:A:D223 A:A:F208 93.77383.58NoNo095
64A:A:D223 A:A:L45 92.02358.14NoNo998
65A:A:L45 A:A:M221 92.32365.65NoYes088
66A:A:L43 A:A:M221 46.23935.65NoYes078
67A:A:F219 A:A:L43 50.54434.87YesNo087
68B:B:M101 B:B:Y59 24.72943.59YesYes198
69B:B:M101 B:B:Y145 24.96799.58YesYes198
70A:A:Q227 B:B:Y145 22.82839.02YesYes198
71A:A:F212 A:A:M221 46.29533.73YesYes098
72A:A:F212 A:A:F219 46.386115YesYes098
73B:B:H54 B:B:I58 13.05897.95YesNo099
74B:B:I58 B:B:S316 13.20123.1NoNo099
75A:A:W281 B:B:W332 11.00629.37YesYes159
76B:B:R314 B:B:W332 10.474222.99YesYes189
77A:A:W281 B:B:D290 10.12388.93YesYes156
78B:B:I18 G:G:E22 36.46322.73YesNo079
79B:B:T221 G:G:E22 36.61688.47NoNo079
80B:B:K209 B:B:T221 36.820913.51YesNo067
81B:B:H183 B:B:K209 38.046119.65YesYes796
82B:B:H183 B:B:V187 39.11025.54YesNo799
83B:B:S160 B:B:V187 40.39734.85YesNo769
84B:B:C148 B:B:S160 40.80873.44NoYes766
85B:B:C148 B:B:T102 47.03453.38NoNo068
86B:B:C149 B:B:T102 47.24626.76NoNo088
87B:B:C121 B:B:C149 31.5393.64YesNo088
88B:B:C121 B:B:L146 15.80833.17YesNo187
89B:B:H142 B:B:L146 15.8765.14YesNo197
90B:B:D163 B:B:H142 46.09168.82YesYes199
91B:B:D163 B:B:G144 46.52075.03YesNo098
92B:B:G144 B:B:N119 46.58645.09NoNo089
93B:B:C121 B:B:T159 15.80813.38YesYes189
94B:B:H142 B:B:T159 15.87586.85YesYes199
95B:B:C149 B:B:I157 15.91944.91NoYes087
96B:B:I157 B:B:W169 16.89233.52YesYes078
97B:B:H142 B:B:W169 19.15084.23YesYes198
98B:B:I18 B:B:R22 10.58845.01YesNo076
99B:B:I18 G:G:R27 20.74443.76YesYes078
100B:B:W297 B:B:Y264 12.397914.47YesYes085
101B:B:W297 B:B:Y289 13.5445.79YesYes187
102B:B:C271 B:B:Y289 18.72674.03YesYes157
103B:B:C271 B:B:D290 19.58923.11YesYes156
104B:B:L210 B:B:Q220 10.37815.32YesYes057
105B:B:D258 B:B:Q220 19.021913.05YesYes677
106B:B:F222 B:B:Q220 17.511711.71NoYes687
107B:B:F222 B:B:F253 14.269310.72NoYes686
108L:L:F22 R:R:W39 34.29596.01YesYes505
109L:L:F22 L:L:L26 21.7417.31YesNo500
110R:R:F66 R:R:R43 10.11035.34YesYes574
111R:R:Y69 R:R:Y88 27.58224.96YesYes565
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L32 R:R:Q213 7.99 5 No No 4 4 1 2
R:R:L32 R:R:W214 4.56 5 No Yes 4 1 1 1
L:L:F22 R:R:L32 3.65 5 Yes No 0 4 0 1
R:R:P90 R:R:T35 5.25 5 Yes No 4 5 2 1
L:L:V19 R:R:T35 3.17 0 No No 0 5 0 1
R:R:R40 R:R:V36 5.23 5 Yes No 2 2 2 1
L:L:F22 R:R:V36 7.87 5 Yes No 0 2 0 1
R:R:R40 R:R:W39 3 5 Yes Yes 2 5 2 1
R:R:R43 R:R:W39 5 5 Yes Yes 4 5 2 1
R:R:W39 R:R:Y88 13.5 5 Yes Yes 5 5 1 1
L:L:F22 R:R:W39 6.01 5 Yes Yes 0 5 0 1
L:L:L26 R:R:W39 7.97 5 No Yes 0 5 0 1
R:R:R40 R:R:R43 4.26 5 Yes Yes 2 4 2 2
R:R:P86 R:R:Y42 4.17 5 Yes Yes 8 6 2 2
R:R:Y42 R:R:Y88 11.91 5 Yes Yes 6 5 2 1
L:L:G29 R:R:E68 3.27 0 No No 0 4 0 1
R:R:P86 R:R:Y69 11.13 5 Yes Yes 8 6 2 1
R:R:Y69 R:R:Y88 4.96 5 Yes Yes 6 5 1 1
R:R:L89 R:R:Y69 5.86 5 Yes Yes 5 6 1 1
L:L:K27 R:R:Y69 7.17 0 No Yes 0 6 0 1
R:R:P86 R:R:Y88 11.13 5 Yes Yes 8 5 2 1
R:R:L89 R:R:P86 3.28 5 Yes Yes 5 8 1 2
R:R:L89 R:R:Y88 3.52 5 Yes Yes 5 5 1 1
L:L:L26 R:R:Y88 3.52 5 No Yes 0 5 0 1
R:R:L89 R:R:P90 3.28 5 Yes Yes 5 4 1 2
R:R:L89 R:R:W91 12.53 5 Yes Yes 5 4 1 1
L:L:I23 R:R:L89 5.71 5 No Yes 0 5 0 1
R:R:P90 R:R:W91 10.81 5 Yes Yes 4 4 2 1
R:R:E128 R:R:W91 13.08 0 No Yes 3 4 1 1
R:R:S129 R:R:W91 4.94 0 No Yes 1 4 2 1
L:L:I23 R:R:W91 7.05 5 No Yes 0 4 0 1
L:L:K27 R:R:L123 5.64 0 No No 0 5 0 1
L:L:R20 R:R:E128 9.3 0 No No 0 3 0 1
L:L:Q13 R:R:E138 8.92 0 No No 0 2 0 1
R:R:L141 R:R:Q140 6.65 0 No No 5 4 1 2
R:R:F381 R:R:Q140 11.71 0 No No 4 4 2 2
L:L:F6 R:R:L141 3.65 2 Yes No 0 5 0 1
L:L:Q13 R:R:L141 5.32 0 No No 0 5 0 1
R:R:F381 R:R:L144 4.87 0 No No 4 6 2 1
R:R:L144 R:R:L388 6.92 2 No No 6 7 1 1
L:L:F6 R:R:L144 3.65 2 Yes No 0 6 0 1
R:R:Y145 R:R:Y148 8.94 2 Yes Yes 5 7 2 1
R:R:T149 R:R:Y145 11.24 2 No Yes 7 5 2 2
R:R:D198 R:R:Y145 10.34 2 No Yes 7 5 2 2
R:R:T149 R:R:Y148 3.75 2 No Yes 7 7 2 1
R:R:Y148 R:R:Y152 5.96 2 Yes Yes 7 7 1 1
R:R:K197 R:R:Y148 3.58 2 Yes Yes 6 7 1 1
R:R:D198 R:R:Y148 10.34 2 No Yes 7 7 2 1
R:R:L388 R:R:Y148 4.69 2 No Yes 7 7 1 1
R:R:S392 R:R:Y148 3.82 2 No Yes 9 7 2 1
L:L:F6 R:R:Y148 12.38 2 Yes Yes 0 7 0 1
R:R:R190 R:R:Y152 8.23 2 Yes Yes 8 7 1 1
R:R:A191 R:R:Y152 4 0 No Yes 7 7 2 1
R:R:V194 R:R:Y152 10.09 0 No Yes 7 7 2 1
R:R:S392 R:R:Y152 16.53 2 No Yes 9 7 2 1
L:L:D3 R:R:Y152 5.75 2 Yes Yes 0 7 0 1
R:R:R190 R:R:V237 15.69 2 Yes No 8 6 1 1
R:R:N240 R:R:R190 10.85 0 No Yes 9 8 2 1
R:R:R190 R:R:Y241 13.38 2 Yes Yes 8 8 1 1
R:R:R190 R:R:T391 6.47 2 Yes Yes 8 6 1 2
L:L:D3 R:R:R190 10.72 2 Yes Yes 0 8 0 1
R:R:D198 R:R:K197 9.68 2 No Yes 7 6 2 1
R:R:F230 R:R:K197 4.96 0 Yes Yes 5 6 2 1
R:R:K197 R:R:M233 7.2 2 Yes No 6 6 1 1
L:L:T7 R:R:K197 15.02 2 No Yes 0 6 0 1
R:R:F230 R:R:L201 4.87 0 Yes Yes 5 7 2 1
L:L:T7 R:R:L201 4.42 2 No Yes 0 7 0 1
L:L:S11 R:R:L201 3 12 Yes Yes 0 7 0 1
L:L:M14 R:R:L201 4.24 0 No Yes 0 7 0 1
R:R:M204 R:R:Y205 8.38 12 Yes Yes 3 3 2 1
R:R:M204 R:R:Q221 10.88 12 Yes Yes 3 4 2 2
R:R:Q221 R:R:Y205 5.64 12 Yes Yes 4 3 2 1
R:R:R299 R:R:Y205 3.09 12 Yes Yes 4 3 1 1
L:L:S11 R:R:Y205 5.09 12 Yes Yes 0 3 0 1
L:L:M14 R:R:Y205 11.97 0 No Yes 0 3 0 1
L:L:E15 R:R:Y205 12.35 12 No Yes 0 3 0 1
R:R:Q210 R:R:W214 4.38 0 No Yes 4 1 1 1
L:L:A18 R:R:Q210 3.03 0 No No 0 4 0 1
L:L:L21 R:R:Q210 3.99 0 No No 0 4 0 1
R:R:Q211 R:R:W214 9.86 0 No Yes 4 1 2 1
R:R:Q213 R:R:Q221 11.52 0 No Yes 4 4 2 2
L:L:F22 R:R:W214 16.04 5 Yes Yes 0 1 0 1
L:L:W25 R:R:W214 26.24 5 No Yes 0 1 0 1
R:R:F230 R:R:T298 7.78 0 Yes No 5 5 2 1
L:L:T7 R:R:M233 6.02 2 No No 0 6 0 1
R:R:Q234 R:R:W284 12.05 2 Yes Yes 7 8 1 2
R:R:Q234 R:R:W306 7.67 2 Yes Yes 7 6 1 1
R:R:I309 R:R:Q234 10.98 2 No Yes 7 7 2 1
L:L:H1 R:R:Q234 8.65 2 Yes Yes 0 7 0 1
L:L:H1 R:R:V237 15.22 2 Yes No 0 6 0 1
L:L:D3 R:R:V237 7.3 2 Yes No 0 6 0 1
R:R:A238 R:R:I313 3.25 0 No No 6 7 2 1
R:R:I313 R:R:Y241 12.09 2 No Yes 7 8 1 1
R:R:I317 R:R:Y241 4.84 2 Yes Yes 7 8 2 1
R:R:E364 R:R:Y241 12.35 2 Yes Yes 8 8 2 1
L:L:H1 R:R:Y241 4.36 2 Yes Yes 0 8 0 1
R:R:I309 R:R:W284 15.27 2 No Yes 7 8 2 2
R:R:G295 R:R:R299 4.5 0 No Yes 4 4 2 1
R:R:R299 R:R:T298 3.88 12 Yes No 4 5 1 1
L:L:S11 R:R:T298 7.99 12 Yes No 0 5 0 1
L:L:S11 R:R:R299 5.27 12 Yes Yes 0 4 0 1
L:L:K12 R:R:R299 7.43 0 No Yes 0 4 0 1
L:L:E15 R:R:R299 12.79 12 No Yes 0 4 0 1
R:R:N300 R:R:W306 25.99 0 No Yes 6 6 1 1
L:L:S8 R:R:N300 8.94 0 No No 0 6 0 1
R:R:M303 R:R:R310 3.72 2 No Yes 5 6 2 2
R:R:D372 R:R:M303 5.54 0 No No 5 5 1 2
R:R:I309 R:R:W306 4.7 2 No Yes 7 6 2 1
R:R:R310 R:R:W306 28.99 2 Yes Yes 6 6 2 1
L:L:H1 R:R:W306 9.52 2 Yes Yes 0 6 0 1
L:L:T5 R:R:W306 3.64 0 No Yes 0 6 0 1
L:L:H1 R:R:I313 3.98 2 Yes No 0 7 0 1
R:R:E364 R:R:I317 5.47 2 Yes Yes 8 7 2 2
R:R:E364 R:R:E387 5.07 2 Yes No 8 8 2 1
R:R:E364 R:R:T391 5.64 2 Yes Yes 8 6 2 2
R:R:D372 R:R:R380 9.53 0 No Yes 5 5 1 1
L:L:T5 R:R:D372 10.12 0 No No 0 5 0 1
R:R:A375 R:R:R380 4.15 0 No Yes 4 5 2 1
L:L:D9 R:R:R380 11.91 0 No Yes 0 5 0 1
R:R:E387 R:R:K383 13.5 0 No No 8 7 1 2
L:L:T5 R:R:L384 5.9 0 No No 0 5 0 1
L:L:G2 R:R:E387 4.91 0 No No 0 8 0 1
L:L:F6 R:R:L388 7.31 2 Yes No 0 7 0 1
L:L:E15 R:R:S31 2.87 12 No No 0 4 0 1
R:R:C126 R:R:Y69 2.69 0 No Yes 9 6 2 1
R:R:A70 R:R:Y69 2.67 0 No Yes 5 6 2 1
R:R:E68 R:R:W39 2.18 0 No Yes 4 5 1 1
R:R:R376 R:R:R380 2.13 0 No Yes 5 5 2 1
R:R:F195 R:R:Y152 2.06 0 No Yes 7 7 2 1
R:R:P137 R:R:S136 1.78 0 No No 3 1 1 2
R:R:A92 R:R:L89 1.58 0 No Yes 5 5 2 1
R:R:P137 R:R:Q140 1.58 0 No No 3 4 1 2
L:L:Q13 R:R:P137 1.58 0 No No 0 3 0 1
R:R:E34 R:R:S31 1.44 0 No No 4 4 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
88.46Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
88.00Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
87.50Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
84.00Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
84.00Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
80.77Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
77.78Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
77.78Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
76.92Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
76.92Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
76.92Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
76.92Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
76.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
76.00Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
75.00Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
74.07Consensusglp_onOrthosteric Ligandglp1_on glp2_on
74.07Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
73.08Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
73.08Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
73.08Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
73.08Consensuspac_onOrthosteric Ligandpac1_on
70.00Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
69.23Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
69.23Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
67.86Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
66.67Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
66.67Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
66.67Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
65.62Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
65.52Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
65.52Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
65.52Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
64.52Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
64.29Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
64.29Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
64.29Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
64.29Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
64.00Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
62.96Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
62.50Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
62.50Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
62.07Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
62.07Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
61.76Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
60.71Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
60.71Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
60.61Consensuspth_onOrthosteric Ligandpth1_on pth2_on
60.00Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
59.38Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
59.26Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
59.26Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
58.62Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
58.62Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
58.33Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
58.06Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
57.58Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
57.58Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
57.58Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
57.14Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
57.14Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
57.14Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
56.67Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
56.67Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
56.67Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
56.00Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
55.17Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
54.84Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
54.84Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
54.55Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
54.55Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
54.55Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
53.33Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
53.33Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
53.33Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
52.94Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
51.72Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
51.72Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
51.61Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
51.52Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
51.28Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
50.00Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
50.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
50.00Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
48.65Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
48.48Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
48.39Single6FJ3PTH6FJ3-PTH1-PTH
48.28Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
46.88Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
46.43Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
45.45Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
45.16Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
44.44Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
43.33Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
41.38Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
41.18Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
41.18Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
41.18Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
41.18Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
41.18Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
40.54Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
40.54Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
39.47Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
39.39Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
39.39Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
39.39Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
39.29Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
38.89Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
38.71Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
38.71Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
38.24Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
38.24Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
38.24Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
37.50Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
37.50Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
37.50Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
36.67Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
36.59Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
36.36Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
36.36Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
36.36Consensuscalcitonin_onOrthosteric Ligandctlike_on
36.36Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.36Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
36.11Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
35.71Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
35.48Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
35.48Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
35.48Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
35.29Single4XT3Fractalkine4XT3-US28-Fractalkine
35.29Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
35.29Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
35.29Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
35.29Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
35.14Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
34.62Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
34.62Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
34.48Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
34.48Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
34.29Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
34.29Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
34.29Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
34.29Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
34.29Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
34.29Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
34.29Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
34.29Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
34.29Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
34.29Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
34.29Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
34.21Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
34.21Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
34.21Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
33.33Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
33.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
33.33Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
33.33Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
33.33Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
33.33Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
33.33Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
33.33Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
33.33Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
33.33Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
33.33Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
33.33Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
33.33Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
33.33Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
33.33Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
33.33Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
33.33Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
33.33Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
33.33Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
33.33Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
33.33Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
33.33Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
33.33Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
33.33Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
32.56Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
32.43Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.43Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.43Consensusbombesin_onOrthosteric Ligandbb2_on
32.43Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
32.43Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
32.43Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
32.43Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.35Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
32.35Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
32.35Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
32.26Single4XT1Fractalkine4XT1-US28-Fractalkine
32.26Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
32.26Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
32.26Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
32.26Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.14Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
32.14Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
32.14Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
31.58Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
31.43Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
31.43Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
31.43Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
31.43Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
31.43Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
31.43Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
31.43Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
31.25Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
31.25Single7XNACYN1548067XNA-SST2-CYN154806
31.25Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
31.25Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
31.25Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
31.25Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
31.25Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
31.03Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
31.03Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
31.03Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
31.03Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
31.03Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
31.03Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
31.03Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
31.03Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
30.95Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
30.56Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
30.56Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
30.56Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
30.56Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
30.30Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
30.30Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
30.30Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.30Consensusangiotensin_onOrthosteric Ligandat1_on
30.30Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
30.30Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
30.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
30.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
30.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
30.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
30.00Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
29.73Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
29.63Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
29.63Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
29.63Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
29.63Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
29.63Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
29.63Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
29.63Consensushca_on_gpOrthosteric Ligandhca2_on_gp
29.41Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
29.41Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.41Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
29.03Single4UG2CGS216804UG2-A2A-CGS21680
29.03Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
29.03Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
28.95Single6IGKEndothelin-36IGK-ETB-Endothelin-3
28.95Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
28.95Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
28.95Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
28.95Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
28.57Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
28.57Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
28.57Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
28.57Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
28.57Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
28.57Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
28.57Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
28.57Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
28.57Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
28.57Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
28.57Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
28.57Single9EHSLUF76029EHS-A3A-LUF7602
28.57Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
28.57Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
28.57Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
28.57Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.57Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
28.57Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
28.57Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
28.21Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
28.12Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
28.12Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
28.12Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
28.12Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.12Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.12Consensuslpl_onOrthosteric Ligands1p_on lpa_on
28.12Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
28.12Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
28.12Consensussomatostatin_offOrthosteric Ligandsst2_off
28.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
28.00Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
28.00Single8K5BNiacin8K5B-HCA2-Niacin
28.00Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
27.78Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
27.78Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
27.59Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
27.59Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
27.59Single7TUYGSK682753A7TUY-GPR183-GSK682753A
27.59Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
27.59Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
27.59Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
27.50Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
27.27Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
27.27Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
27.27Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
27.27Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
27.27Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
27.27Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
27.27Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
27.27Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
27.27Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
27.27Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
27.03Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
27.03Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
27.03Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
26.92Single4BWBNeurotensin4BWB-NTS1-Neurotensin
26.92Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
26.92Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
26.92Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
26.92Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.92Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.92Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.92Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.67Single4XEENeurotensin4XEE-NTS1-Neurotensin
26.67Single4XESNeurotensin4XES-NTS1-Neurotensin
26.67Single6OS2TRV0266OS2-AT1-TRV026
26.67Single6YVRNTS8-136YVR-NTS1-NTS8-13
26.67Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
26.67Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
26.67Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
26.67Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
26.67Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
26.67Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
26.67Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
26.67Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
26.67Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
26.67Single8XYIVUF106618XYI-CXCR3-VUF10661
26.67Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
26.67Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
26.67Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
26.67Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
26.67Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
26.67Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
26.67Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
26.67Consensuslpa_offOrthosteric Ligandlpa1_off
26.67Consensuslpl_offOrthosteric Ligands1p_off lpa_off
26.67Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
26.47Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
26.47Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
26.47Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
26.47Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
26.47Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
26.47Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
26.47Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
26.47Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
26.47Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
26.47Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
26.47Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
26.32Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
26.32Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
26.19Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
25.93Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
25.93Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
25.93Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
25.93Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
25.93Single8K5CAcipimox8K5C-HCA2-Acipimox
25.93Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
25.93Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Consensushca_onOrthosteric Ligandhca2_on
25.81Single4BUONeurotensin4BUO-NTS1-Neurotensin
25.81Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
25.81Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
25.81Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
25.81Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
25.81Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
25.81Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
25.81Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
25.81Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
25.81Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
25.81Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
25.81Consensuscck_onOrthosteric Ligandccka_on cckb_on
25.81Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
25.81Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
25.81Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.81Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.71Single6JODAngiotensin II6JOD-AT2-Angiotensin II
25.71Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.71Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
25.71Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
25.71Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
25.71Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
25.71Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
25.71Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
25.71Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
25.71Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.71Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
25.71Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
25.71Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.71Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.71Consensusvasop-oxy_onOrthosteric Ligandv2_on
25.71Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
25.64Single5GLHEndothelin-15GLH-ETB-Endothelin-1
25.64Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
25.64Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
25.00Single4YAYZD-71554YAY-AT1-ZD-7155
25.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
25.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
25.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
25.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
25.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
25.00Single7SK9CCX6627SK9-ACKR3-CCX662
25.00Single7V3ZCP559407V3Z-CB1-CP55940
25.00Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
25.00Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
25.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
25.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
25.00Single8K5DGSK2560738K5D-HCA2-GSK256073
25.00Single8QJ2pN1628QJ2-MC4-pN162-Gs
25.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
25.00Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
25.00Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
25.00Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
25.00Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
25.00Single8ZRTET-18ZRT-ETB-ET-1
25.00Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
25.00Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
25.00Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
25.00Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
25.00Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
25.00Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
25.00Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
25.00Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
25.00Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
25.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.00Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
25.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
25.00Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
25.00Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
25.00Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
25.00Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
24.39Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
24.39Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
24.32Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
24.32Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
24.32Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
24.32Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
24.32Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
24.32Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
24.24Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
24.24Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
24.24Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
24.24Single7QA8Peptide7QA8-STE2-Peptide
24.24Single7QA8Peptide7QA8-STE2-Peptide
24.24Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
24.24Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
24.24Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
24.24Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
24.24Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
24.24Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
24.24Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
24.24Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
24.24Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
24.24Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
24.24Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
24.14Single5C1MBU725C1M-μ-BU72
24.14Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
24.14Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
24.14Single7C4SS1P7C4S-S1P3-S1P
24.14Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
24.14Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.14Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
24.14Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
24.14Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
24.14Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
24.14Single8S4DCMF-0198S4D-Apelin-CMF-019
24.14Single8TF5Oleic acid8TF5-GPR6-Oleic acid
24.14Single9B9ZA1AKO9B9Z-CB1-A1AKO
24.14Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
24.14Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
24.14Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
24.14Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
24.00Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
24.00Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
23.81Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
23.68Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.68Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
23.68Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
23.68Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
23.68Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
23.68Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
23.53Single3QAKUK-4320973QAK-A2A-UK-432097
23.53Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
23.53Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
23.53Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
23.53Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
23.53Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
23.53Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
23.53Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
23.53Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
23.53Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
23.33Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
23.33Single4BV0Neurotensin4BV0-NTS1-Neurotensin
23.33Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
23.33Single5XR8AM8415XR8-CB1-AM841
23.33Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
23.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
23.33Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
23.33Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
23.33Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
23.33Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
23.33Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
23.33Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.33Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
23.33Single8E0GBU728E0G-μ-BU72
23.33Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
23.33Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
23.33Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
23.33Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
23.33Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
23.33Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
23.33Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
23.33Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
23.33Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
23.33Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
23.33Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
23.33Consensusneurotensin_onOrthosteric Ligandnts1_on
23.33Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
23.08Single6IGLIRL16206IGL-ETB-IRL1620
23.08Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
23.08Single8IY6Endothelin-18IY6-ETB-Endothelin-1
23.08Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
23.08Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
23.08Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
23.08Consensusbradykinin_onOrthosteric Ligandbk2_on
23.08Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
23.08Consensusendothelin_onOrthosteric Ligandetb_on eta_on
23.08Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
23.08Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
22.86Single5WF5UK-4320975WF5-A2A-UK-432097
22.86Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
22.86Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
22.86Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
22.86Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
22.86Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.86Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.86Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
22.86Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
22.86Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
22.86Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
22.86Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
22.86Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
22.73Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
22.73Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
22.58Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
22.58Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
22.58Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
22.58Single6A93Risperidone6A93-5-HT2A-Risperidone
22.58Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
22.58Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
22.58Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
22.58Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
22.58Single7DFPSpiperone7DFP-D2-Spiperone
22.58Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.58Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
22.58Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
22.58Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
22.58Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
22.58Single8JWY2-1188JWY-A2A-2-118
22.58Single8JWZAB9288JWZ-A2A-AB928-Na
22.58Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
22.58Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
22.58Single9DGIZ85267113509DGI-CB1-Z8526711350
22.58Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
22.58Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
22.58Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
22.58Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
22.58Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
22.58Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
22.58Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
22.58Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
22.58Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
22.58Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
22.58Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
22.58Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
22.22Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
22.22Single5U09Taranabant5U09-CB1-Taranabant
22.22Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
22.22Single5ZKQABT-4915ZKQ-PAF-ABT-491
22.22Single6AKXA4R6AKX-CCR5-A4R
22.22Single6AKYMaraviroc6AKY-CCR5-Maraviroc
22.22Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
22.22Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
22.22Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
22.22Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
22.22Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
22.22Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
22.22Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
22.22Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
22.22Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
22.22Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
22.22Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
22.22Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
22.22Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
22.22Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
22.22Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
22.22Consensusangiotensin_offOrthosteric Ligandat1_off
22.22Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
22.22Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
22.22Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
22.22Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
22.22Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
22.22Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
22.22Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
22.22Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
21.95Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
21.88Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
21.88Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
21.88Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
21.88Single7EZCUKA7EZC-A2A-UKA
21.88Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
21.88Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
21.88Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
21.88Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.88Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
21.88Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
21.88Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
21.88Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
21.88Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
21.88Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
21.88Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
21.88Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
21.88Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
21.88Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
21.88Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
21.88Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
21.88Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
21.88Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
21.88Consensuschemerin_onOrthosteric Ligandcml1_on
21.88Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.88Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.88Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.88Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
21.88Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
21.88Consensusprostanoid_offOrthosteric Ligandep_off dp_off
21.62Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
21.62Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
21.62Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
21.62Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
21.62Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
21.62Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
21.62Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
21.62Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
21.62Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
21.43Single4MBSMaraviroc4MBS-CCR5-Maraviroc
21.43Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
21.43Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
21.43Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
21.43Single7F61PF-036547467F61-H3-PF-03654746
21.43Single7T32ZM-2413857T32-A2A-ZM-241385
21.43Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
21.43Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
21.43Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
21.43Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
21.43Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
21.43Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
21.43Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
21.43Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
21.43Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
21.43Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
21.43Single8RLNLUF58348RLN-A2A-LUF5834
21.43Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
21.43Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
21.43Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
21.43Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.43Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
21.43Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
21.43Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
21.43Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
21.43Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
21.43Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
21.43Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
21.43Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
21.43Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
21.43Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
21.43Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
21.21Single3NY9ICI118-5513NY9-β2-ICI118-551
21.21Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
21.21Single5ZTYAM102575ZTY-CB2-AM10257
21.21Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
21.21Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
21.21Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
21.21Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
21.21Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
21.21Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
21.21Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
21.21Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
21.21Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
21.21Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
21.21Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
21.21Single9IPYJR14a9IPY-C3aB-JR14a
21.21Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
21.21Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
21.21Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
21.21Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
21.05Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
21.05Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
21.05Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
21.05Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
21.05Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
21.05Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
21.05Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
20.83Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
20.83Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
20.69Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
20.69Single5T04Neurotensin5T04-NTS1-Neurotensin
20.69Single5UENDU1725UEN-A1-DU172
20.69Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
20.69Single6PS1Timolol6PS1-β2-Timolol
20.69Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
20.69Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
20.69Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
20.69Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
20.69Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
20.69Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
20.69Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
20.69Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
20.69Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
20.69Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
20.69Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
20.69Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
20.69Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
20.69Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.69Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.69Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.69Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
20.69Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
20.69Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
20.69Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
20.69Single9CHXS-Carazolol9CHX-β2-S-Carazolol
20.69Consensusa3_onOrthosteric Liganda3a_on
20.69Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
20.69Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
20.69Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
20.59Single7F8XNN90567F8X-CCKA-NN9056
20.59Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
20.59Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
20.59Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
20.59Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
20.59Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
20.59Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
20.59Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
20.59Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
20.59Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
20.59Single8WDTphotoNECA8WDT-A2A-photoNECA
20.59Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
20.59Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.59Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
20.59Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
20.59Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
20.51Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
20.51Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.00Single5N2RPSB-365N2R-A2A-PSB-36-Na
20.00Single5N2SPSB365N2S-A1-PSB36
20.00Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
20.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
20.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
20.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
20.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
20.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
20.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
20.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
20.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
20.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
20.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
20.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
20.00Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
20.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
20.00Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
20.00Single7SK5CXCL127SK5-ACKR3-CXCL12
20.00Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
20.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
20.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
20.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
20.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
20.00Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
20.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
20.00Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
20.00Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8JXSPF-61428JXS-D1-PF-6142
20.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
20.00Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.00Single8QOTNanobody-E8QOT-μ-Nanobody-E
20.00Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
20.00Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
20.00Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
20.00Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
20.00Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
20.00Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
20.00Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
20.00Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
20.00Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
20.00Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
20.00Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
20.00Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
20.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
20.00Consensusa3_on_gpOrthosteric Liganda3a_on_gp
20.00Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
20.00Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
20.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
20.00Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
20.00Consensusblt_offOrthosteric Ligandblt1_off
20.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
20.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
20.00Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
20.00Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
20.00Consensusdp_offOrthosteric Liganddp2_off
20.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
20.00Consensusep_offOrthosteric Ligandep4_off
20.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
20.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
20.00Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
20.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
20.00Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
20.00Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
20.00Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
20.00Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
20.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Consensustrace-amine_onOrthosteric Ligandta1_on
19.51Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
19.51Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
19.44Single3OE0CVX153OE0-CXCR4-CVX15
19.44Single6PT2KGCHM076PT2-δ-KGCHM07
19.44Single6W25SHU91196W25-MC4-SHU9119-Ca
19.44Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
19.44Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
19.44Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
19.44Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
19.44Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
19.44Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
19.44Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
19.44Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
19.44Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single2YDVNECA2YDV-A2A-NECA
19.35Single3P0GBI1671073P0G-β2-BI167107
19.35Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
19.35Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
19.35Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
19.35Single4UHRCGS216804UHR-A2A-CGS21680
19.35Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
19.35Single5G53NECA5G53-A2A-NECA-Gs
19.35Single5XRAAM115425XRA-CB1-AM11542
19.35Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
19.35Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
19.35Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
19.35Single6OS1TRV0266OS1-AT1-TRV026
19.35Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
19.35Single7FEECP559407FEE-CB1-CP55940-ZCZ011
19.35Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
19.35Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
19.35Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
19.35Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
19.35Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
19.35Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.35Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
19.35Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
19.35Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
19.35Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
19.35Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
19.35Single8EA0Iperoxo8EA0-M3-Iperoxo
19.35Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.35Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
19.35Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
19.35Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
19.35Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
19.35Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
19.35Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
19.35Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
19.35Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
19.35Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
19.35Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
19.35Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
19.35Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
19.35Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
19.35Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
19.35Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
19.35Single8ZWFJR14a8ZWF-C3aB-JR14a
19.35Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
19.35Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
19.35Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
19.35Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
19.35Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
19.35Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
19.35Consensusa2_onOrthosteric Liganda2b_on
19.35Consensusa2_on_gpOrthosteric Liganda2b_on_gp
19.35Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
19.35Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
19.35Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
19.35Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
19.35Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
19.35Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
19.35Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
19.35Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
19.35Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
19.35Consensuslpa_onOrthosteric Ligandlpa1_on
19.35Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
19.35Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
19.35Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
19.35Consensusrelaxin_onOrthosteric Ligandrxfp4_on
19.35Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
19.35Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.35Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
19.23Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
19.23Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
19.05Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
19.05Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
18.92Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
18.92Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
18.92Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
18.75Single4N4WSANT-14N4W-SMO-SANT-1
18.75Single6CM4Risperidone6CM4-D2-Risperidone
18.75Single6KQICP559406KQI-CB1-CP55940-Org27569
18.75Single6MXTSalmeterol6MXT-β2-Salmeterol
18.75Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
18.75Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
18.75Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
18.75Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
18.75Single7K15MKD0467K15-BLT1-MKD046-Na
18.75Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
18.75Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
18.75Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
18.75Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
18.75Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
18.75Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single7YITNalfurafine7YIT-κ-Nalfurafine
18.75Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
18.75Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
18.75Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
18.75Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
18.75Single8JJ8Formoterol8JJ8-β2-Formoterol
18.75Single8JJLOlodaterol8JJL-β2-Olodaterol
18.75Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
18.75Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
18.75Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
18.75Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
18.75Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
18.75Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
18.75Consensusalpha1_offOrthosteric Ligandalpha1a_off
18.75Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
18.75Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
18.75Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
18.75Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
18.75Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
18.75Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
18.75Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
18.75Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
18.75Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
18.75Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
18.75Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
18.75Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
18.75Consensusorexin_onOrthosteric Ligandox2_on
18.52Single3OE9IT1t3OE9-CXCR4-IT1t
18.52Single6LI0C176LI0-GPR52-C17
18.52Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
18.52Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
18.52Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
18.52Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
18.52Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
18.52Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
18.52Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
18.52Single9B9Y7DY9B9Y-CB1-7DY
18.52Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
18.52Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
18.42Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
18.42Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
18.42Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
18.42Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
18.42Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
18.18Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
18.18Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
18.18Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
18.18Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
18.18Single5X93K-87945X93-ETB-K-8794
18.18Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
18.18Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
18.18Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
18.18Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
18.18Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
18.18Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
18.18Single7UM4AS26747237UM4-5-HT5A-AS2674723
18.18Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
18.18Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
18.18Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
18.18Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
18.18Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
18.18Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
18.18Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
18.18Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.18Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8XVUCXCL28XVU-CXCR2-CXCL2
18.18Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
18.18Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
18.18Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
18.18Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
18.18Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
18.18Consensusendothelin_offOrthosteric Ligandetb_off
18.18Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
18.18Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
18.18Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
18.18Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
18.18Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
18.18Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
17.95Single7SK3CXCL127SK3-ACKR3-CXCL12
17.95Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
17.86Single3PWHZM-2413853PWH-A2A-ZM-241385
17.86Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
17.86Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
17.86Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
17.86Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
17.86Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
17.86Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
17.86Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
17.86Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
17.86Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
17.86Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
17.86Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
17.86Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
17.86Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
17.86Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
17.86Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
17.86Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.86Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
17.86Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
17.86Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
17.86Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
17.86Single8GNGIstradefylline8GNG-A2A-Istradefylline
17.86Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
17.86Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
17.86Single8IWESpermidine8IWE-TA9-Spermidine
17.86Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
17.86Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
17.86Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
17.86Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
17.86Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
17.86Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
17.86Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
17.86Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
17.86Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
17.86Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
17.86Consensusalpha2_offOrthosteric Ligandalpha2c_off
17.65Single5WF6UK-4320975WF6-A2A-UK-432097
17.65Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
17.65Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
17.65Single6PT3DPI-2876PT3-δ-DPI-287
17.65Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
17.65Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
17.65Single7XN9L-054,5227XN9-SST2-L-054,522
17.65Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
17.65Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
17.65Single8X5YAstemizole8X5Y-H1-Astemizole
17.65Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
17.65Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
17.65Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
17.65Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
17.65Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
17.65Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
17.65Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
17.65Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
17.50Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
17.50Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
17.24Single2YDOAdenosine2YDO-A2A-Adenosine
17.24Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
17.24Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
17.24Single5IU7Q274563465IU7-A2A-Q27456346-Na
17.24Single5IUBQ274563445IUB-A2A-Q27456344-Na
17.24Single5JTBZM-2413855JTB-A2A-ZM-241385
17.24Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
17.24Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
17.24Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
17.24Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
17.24Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
17.24Single6PS0S-Carazolol6PS0-β2-S-Carazolol
17.24Single6PS4ICI118-5516PS4-β2-ICI118-551
17.24Single6PS5S-Propranolol6PS5-β2-S-Propranolol
17.24Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
17.24Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
17.24Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
17.24Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
17.24Single7AROLUF58337ARO-A2A-LUF5833-Na
17.24Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
17.24Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.24Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
17.24Single7UL3Famotidine7UL3-H2-Famotidine
17.24Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
17.24Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
17.24Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
17.24Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
17.24Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
17.24Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
17.24Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
17.24Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
17.24Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
17.24Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
17.24Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
17.24Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
17.24Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
17.24Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
17.24Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
17.24Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
17.24Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
17.24Single8IHKAcifran8IHK-HCA3-Acifran
17.24Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
17.24Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
17.24Single8K2WAMG4878K2W-CXCR3-AMG487
17.24Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
17.24Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
17.24Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
17.24Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
17.24Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
17.24Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
17.24Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
17.24Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8ZPMAMD0708ZPM-CXCR4-AMD070
17.24Single9AS5Mescaline9AS5-5-HT2A-Mescaline
17.24Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single9BA0A1AKN9BA0-CB1-A1AKN
17.24Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
17.24Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
17.24Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
17.24Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
17.24Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
17.24Consensusa2_offOrthosteric Liganda2a_off
17.24Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
17.24Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
17.24Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
17.24Consensusgrh_offOrthosteric Ligandgnrh1_off
17.24Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
17.24Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
17.14Single4IARErgotamine4IAR-5-HT1B-Ergotamine
17.14Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
17.14Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.14Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
17.14Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
17.14Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
17.14Single8KIGSHU91198KIG-MC3-SHU9119-Ca
17.14Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
17.14Single8WKYPG-9348WKY-MC4-PG-934
17.14Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.14Single8XWNCXCL88XWN-CXCR2-CXCL8
17.14Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
17.14Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
17.14Single9M4TSilodosin9M4T-Alpha1A-Silodosin
17.14Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
17.07Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
16.67Single2Y04Salbutamol2Y04-β1-Salbutamol
16.67Single3EMLZM-2413853EML-A2A-ZM-241385
16.67Single3NY8ICI118-5513NY8-β2-ICI118-551
16.67Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
16.67Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
16.67Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
16.67Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
16.67Single4GBRS-Carazolol4GBR-β2-S-Carazolol
16.67Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
16.67Single4QKX35V4QKX-β2-35V
16.67Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
16.67Single5DHHSB-6121115DHH-NOP-SB-612111
16.67Single5IU8Q274563475IU8-A2A-Q27456347-Na
16.67Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
16.67Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
16.67Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
16.67Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
16.67Single5UIGCmpd-15UIG-A2A-Cmpd-1
16.67Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
16.67Single6D27CAY104716D27-DP2-CAY10471
16.67Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
16.67Single6GPSMK08126GPS-CCR2-MK0812
16.67Single6H7MSalbutamol6H7M-β1-Salbutamol
16.67Single6HLOAprepitant6HLO-NK1-Aprepitant
16.67Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
16.67Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
16.67Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
16.67Single6S0LZM-2413856S0L-A2A-ZM-241385
16.67Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
16.67Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
16.67Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
16.67Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
16.67Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
16.67Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
16.67Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
16.67Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
16.67Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
16.67Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
16.67Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
16.67Single7PYRPSB-21157PYR-A2A-PSB-2115
16.67Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
16.67Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
16.67Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
16.67Single7UL4Alvimopan7UL4-μ-Alvimopan
16.67Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
16.67Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
16.67Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
16.67Single7WC7Lisuride7WC7-5-HT2A-Lisuride
16.67Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
16.67Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
16.67Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
16.67Single8CU6LJ-45178CU6-A2A-LJ-4517
16.67Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
16.67Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
16.67Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
16.67Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
16.67Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
16.67Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
16.67Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
16.67Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
16.67Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
16.67Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
16.67Single8JJOAlprenolol8JJO-β2-Alprenolol
16.67Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
16.67Single8JXRLSD8JXR-D1-LSD
16.67Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
16.67Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
16.67Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
16.67Single8T1WCVN4248T1W-GPR6-CVN424
16.67Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
16.67Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
16.67Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
16.67Single8X63Mepyramine8X63-H1-Mepyramine
16.67Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
16.67Single9AS1DMT9AS1-5-HT2A-DMT
16.67Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
16.67Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
16.67Single9H37A1IR09H37-A2A-A1IR0-Na
16.67Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
16.67Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
16.67Consensus5ht5_onOrthosteric Ligand5ht5a_on
16.67Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
16.67Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
16.67Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
16.67Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
16.67Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
16.67Consensusblt_onOrthosteric Ligandblt1_on
16.67Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
16.67Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
16.67Consensusdopamine_offOrthosteric Ligandd2_off d3_off
16.67Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
16.67Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
16.67Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
16.67Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
16.67Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
16.67Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
16.67Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
16.67Consensushistamine_offOrthosteric Ligandh1_off
16.67Consensusleukotriene_onOrthosteric Ligandblt_on
16.67Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
16.67Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
16.67Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
16.28Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
16.22Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.22Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
16.22Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
16.22Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.22Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.13Single2RH1S-Carazolol2RH1-β2-S-Carazolol
16.13Single2Y03Isoprenaline2Y03-β1-Isoprenaline
16.13Single2YCWS-Carazolol2YCW-β1-S-Carazolol
16.13Single4JKVTaladegib4JKV-SMO-Taladegib
16.13Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
16.13Single5D6LS-Carazolol5D6L-β2-S-Carazolol
16.13Single5IUAQ274563485IUA-A2A-Q27456348-Na
16.13Single5JQHS-Carazolol5JQH-β2-S-Carazolol
16.13Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
16.13Single5TVNLSD5TVN-5-HT2B-LSD
16.13Single5WIUNemonapride5WIU-D4-Nemonapride
16.13Single5WIVNemonapride5WIV-D4-Nemonapride-Na
16.13Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
16.13Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
16.13Single6E67BI1671076E67-β2-BI167107-Gs(CT)
16.13Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
16.13Single6GPXMK08126GPX-CCR2-MK0812
16.13Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
16.13Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
16.13Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
16.13Single6LUQHaloperidol6LUQ-D2-Haloperidol
16.13Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
16.13Single6PS6Timolol6PS6-β2-Timolol
16.13Single6S0QZM-2413856S0Q-A2A-ZM-241385
16.13Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
16.13Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
16.13Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
16.13Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
16.13Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
16.13Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
16.13Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
16.13Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
16.13Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
16.13Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
16.13Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
16.13Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
16.13Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
16.13Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
16.13Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
16.13Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.13Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.13Single8GNEKW-63568GNE-A2A-KW-6356-Na
16.13Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
16.13Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
16.13Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
16.13Single8ZMFA1L108ZMF-5-HT2C-A1L10
16.13Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
16.13Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
16.13Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
16.13Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.13Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
16.13Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
16.13Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
16.13Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
16.13Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
16.13Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
16.13Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
16.13Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
16.13Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
16.13Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
16.13Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
16.13Consensusamine_offonOrthosteric Ligandamine_off amine_on
16.13Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
16.13Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
16.13Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
16.13Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
16.13Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
16.13Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.13Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
16.13Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
16.13Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
16.13Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
16.13Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
16.13Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
16.13Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
16.00Single8HS2Fab0468HS2-GPR20-Fab046
15.79Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
15.79Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
15.62Single4DJHJDTic4DJH-κ-JDTic
15.62Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
15.62Single5D5AS-Carazolol5D5A-β2-S-Carazolol
15.62Single5D5BS-Carazolol5D5B-β2-S-Carazolol
15.62Single5V54Methiothepin5V54-5-HT1B-Methiothepin
15.62Single5V56TC1145V56-SMO-TC114
15.62Single5V57TC1145V57-SMO-TC114
15.62Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
15.62Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
15.62Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
15.62Single6H7JIsoprenaline6H7J-β1-Isoprenaline
15.62Single6J21Aprepitant6J21-NK1-Aprepitant
15.62Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
15.62Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
15.62Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
15.62Single6TQ7SB-3348676TQ7-OX1-SB-334867
15.62Single6WGTLSD6WGT-5-HT2A-LSD
15.62Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
15.62Single7B6WCyclazosin7B6W-α1b-Cyclazosin
15.62Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
15.62Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
15.62Single7F1TMIP-1a7F1T-CCR5-MIP-1a
15.62Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
15.62Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
15.62Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
15.62Single7PX4PSB-21137PX4-A2A-PSB-2113
15.62Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
15.62Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
15.62Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
15.62Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
15.62Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
15.62Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
15.62Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
15.62Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
15.62Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
15.62Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
15.62Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.62Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
15.62Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
15.62Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
15.62Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
15.62Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
15.62Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
15.62Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
15.62Single9BJKNaloxone9BJK-μ-Naloxone-NAM
15.62Consensus5ht1_offOrthosteric Ligand5ht1b_off
15.62Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
15.62Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
15.62Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
15.62Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
15.62Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
15.62Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.62Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
15.62Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
15.62Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
15.62Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
15.62Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
15.38Single8A2OTheophylline8A2O-A2A-Theophylline-Na
15.38Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
15.38Single9CHUNoradrenaline9CHU-β2-Noradrenaline
15.38Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
15.15Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
15.15Single3D4STimolol3D4S-β2-Timolol
15.15Single4AMIBucindolol4AMI-β1-Bucindolol
15.15Single4LDEBI1671074LDE-β2-BI167107
15.15Single4RWADIPP-NH24RWA-δ-DIPP-NH2
15.15Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
15.15Single5X33BIIL2605X33-BLT1-BIIL260
15.15Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
15.15Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
15.15Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
15.15Single6IIURamatroban6IIU-TXA2-Ramatroban
15.15Single6ZG4HTL00099366ZG4-M1-HTL0009936
15.15Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
15.15Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
15.15Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.15Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
15.15Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
15.15Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
15.15Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
15.15Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
15.15Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
15.15Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.15Single8XWMCXCL68XWM-CXCR2-CXCL6
15.15Single8XWSCXCL58XWS-CXCR2-CXCL5
15.15Single9BJKNAM9BJK-μ-Naloxone-NAM
15.15Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.15Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
15.15Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
15.15Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
15.15Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
15.15Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
15.15Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.15Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.81Single3OE6IT1t3OE6-CXCR4-IT1t
14.81Single4XNWMRS25004XNW-P2Y1-MRS2500
14.81Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
14.81Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
14.81Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
14.81Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
14.81Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
14.81Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
14.81Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
14.81Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
14.81Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.81Single9LRCHistamine9LRC-H4-Histamine
14.81Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
14.81Consensus5ht2_onOrthosteric Ligand5ht2b_on
14.81Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
14.81Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
14.81Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
14.71Single5CGDHTL142425CGD-mGlu5-HTL14242
14.71Single6H7LDobutamine6H7L-β1-Dobutamine
14.71Single6IBLArformoterol6IBL-β1-Arformoterol
14.71Single6K1QIRL25006K1Q-ETB-IRL2500
14.71Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
14.71Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
14.71Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
14.71Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
14.71Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
14.71Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single8XVJMacitentan8XVJ-ETA-Macitentan
14.71Single8XWFCXCL38XWF-CXCR2-CXCL3
14.71Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
14.71Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
14.71Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
14.71Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
14.71Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
14.63Single9KDFRES-701-39KDF-ETB-RES-701-3
14.29Single4O9RCyclopamine4O9R-SMO-Cyclopamine
14.29Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
14.29Single7SRQLSD7SRQ-5-HT2B-LSD
14.29Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
14.29Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
14.29Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
14.29Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
14.29Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
14.29Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
14.29Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
14.29Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
14.29Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
14.29Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
14.29Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
14.29Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
14.29Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
14.29Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
14.29Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
14.29Single8XQJJN2418XQJ-Apelin-JN241
14.29Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
14.29Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
14.29Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
14.29Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
14.29Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
14.29Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
14.29Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
14.29Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
14.29Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
14.29Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
14.29Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
14.29Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
14.29Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
14.29Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
14.29Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
13.89Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
13.89Single8IEBA1LYA8IEB-GPR156-A1LYA
13.89Single8IEIA1LYA8IEI-GPR156-A1LYA
13.89Single8IEPA1LYA8IEP-GPR156-A1LYA
13.89Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
13.89Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
13.89Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
13.79Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
13.79Single3ODUIT1t3ODU-CXCR4-IT1t
13.79Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
13.79Single4QINSAG1.54QIN-SMO-SAG1.5
13.79Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
13.79Single6B73MP11046B73-κ-MP1104
13.79Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
13.79Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
13.79Single6ME2Ramelteon6ME2-MT1-Ramelteon
13.79Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
13.79Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.79Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
13.79Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
13.79Single7BR3Elagolix7BR3-GnRH1-Elagolix
13.79Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
13.79Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
13.79Single7F8ULintitript7F8U-CCKA-Lintitript
13.79Single7F8YDevazepide7F8Y-CCKA-Devazepide
13.79Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
13.79Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
13.79Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
13.79Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
13.79Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
13.79Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
13.79Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
13.79Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
13.79Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
13.79Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
13.79Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
13.79Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
13.79Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
13.79Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
13.79Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
13.79Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
13.79Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
13.79Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
13.79Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
13.79Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
13.79Single8Y0HVUF114188Y0H-CXCR3-VUF11418
13.79Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
13.79Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
13.79Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
13.79Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
13.79Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
13.79Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
13.79Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
13.79Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
13.79Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
13.79Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
13.79Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
13.79Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
13.79Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
13.79Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
13.79Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
13.79Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
13.79Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
13.79Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
13.79Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
13.79Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
13.79Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
13.79Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
13.79Consensusorexin_offOrthosteric Ligandox2_off ox1_off
13.79Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
13.79Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
13.79Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.79Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
13.79Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
13.51Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.51Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
13.51Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
13.51Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
13.51Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
13.33Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
13.33Single3REYXAC3REY-A2A-XAC
13.33Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
13.33Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
13.33Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
13.33Single4ZJCSB-6740424ZJC-OX1-SB-674042
13.33Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
13.33Single5UVIZM-2413855UVI-A2A-ZM-241385
13.33Single6A94Zotepine6A94-5-HT2A-Zotepine
13.33Single6AQFZM-2413856AQF-A2A-ZM-241385
13.33Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
13.33Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
13.33Single6KUXRS-799486KUX-α2a-RS-79948
13.33Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
13.33Single6MH8ZM-2413856MH8-A2A-ZM-241385
13.33Single6TPGEMPA6TPG-OX2-EMPA
13.33Single6V9SGTPL114036V9S-OX1-GTPL11403
13.33Single6VI4JDTic6VI4-κ-JDTic
13.33Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
13.33Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
13.33Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
13.33Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
13.33Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
13.33Single6ZG9GSK10347026ZG9-M1-GSK1034702
13.33Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
13.33Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
13.33Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
13.33Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
13.33Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
13.33Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
13.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.33Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
13.33Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
13.33Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
13.33Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
13.33Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
13.33Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
13.33Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
13.33Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
13.33Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
13.33Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
13.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
13.33Single8ZPNAMD31008ZPN-CXCR4-AMD3100
13.33Single9AS3LSD9AS3-5-HT2A-LSD
13.33Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
13.33Consensusalpha1_onOrthosteric Ligandalpha1a_on
13.33Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
13.33Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
13.33Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
13.33Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
13.33Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
13.33Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
13.33Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
13.33Consensusopsins_offOrthosteric Ligandrhodopsin_off
13.33Consensussensory_offOrthosteric Ligandopsins_off
13.16Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.16Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
13.16Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
13.16Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
12.90Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
12.90Single2Y01Dobutamine2Y01-β1-Dobutamine
12.90Single2Y02Carmoterol2Y02-β1-Carmoterol
12.90Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
12.90Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
12.90Single4DAJTiotropium4DAJ-M3-Tiotropium
12.90Single4EJ4Naltrindole4EJ4-δ-Naltrindole
12.90Single4MQSIperoxo4MQS-M2-Iperoxo
12.90Single4U14Tiotropium4U14-M3-Tiotropium
12.90Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
12.90Single5DHGC-355DHG-NOP-C-35
12.90Single5TGZAM65385TGZ-CB1-AM6538
12.90Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
12.90Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
12.90Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
12.90Single6DRXLisuride6DRX-5-HT2B-Lisuride
12.90Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
12.90Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
12.90Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
12.90Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
12.90Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
12.90Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
12.90Single6TOTLemborexant6TOT-OX1-Lemborexant
12.90Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
12.90Single7BU7BI1671077BU7-β1-BI167107
12.90Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
12.90Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
12.90Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
12.90Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
12.90Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
12.90Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
12.90Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
12.90Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
12.90Single7YXAONO-54306087YXA-S1P5-ONO-5430608
12.90Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
12.90Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
12.90Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
12.90Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
12.90Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
12.90Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
12.90Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
12.90Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
12.90Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
12.90Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
12.90Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
12.90Single8X64Desloratadine8X64-H1-Desloratadine
12.90Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
12.90Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
12.90Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
12.90Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
12.90Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
12.90Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
12.90Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
12.90Single9JEAAtropine9JEA-M1-Atropine
12.90Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
12.90Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
12.90Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
12.90Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
12.90Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
12.90Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
12.90Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
12.90Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
12.90Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
12.90Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
12.90Consensusalpha2_onOrthosteric Ligandalpha2b_on
12.90Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
12.90Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
12.90Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
12.90Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
12.90Consensuscck_offOrthosteric Ligandccka_off
12.90Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
12.90Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
12.90Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
12.90Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
12.90Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
12.90Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
12.90Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
12.90Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
12.82Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
12.82Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
12.82Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
12.82Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
12.82Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
12.50Single2Y00Dobutamine2Y00-β1-Dobutamine
12.50Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
12.50Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
12.50Single5CGCHTL142425CGC-mGlu5-HTL14242
12.50Single5WQCEMPA5WQC-OX2-EMPA
12.50Single5XPRBosentan5XPR-ETB-Bosentan
12.50Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
12.50Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
12.50Single6TP6Filorexant6TP6-OX1-Filorexant
12.50Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
12.50Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
12.50Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
12.50Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
12.50Single7W41PD1762527W41-BB2-PD176252
12.50Single7WC6LSD7WC6-5-HT2A-LSD
12.50Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
12.50Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
12.50Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
12.50Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
12.50Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
12.50Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
12.50Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
12.50Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
12.50Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
12.50Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
12.50Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
12.50Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
12.50Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
12.50Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
12.50Consensusbombesin_offOrthosteric Ligandbb2_off
12.50Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
12.50Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
12.50Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
12.50Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.12Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
12.12Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
12.12Single4U15Tiotropium4U15-M3-Tiotropium
12.12Single6J20Aprepitant6J20-NK1-Aprepitant
12.12Single6OL9Tiotropium6OL9-M5-Tiotropium
12.12Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
12.12Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
12.12Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
12.12Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
12.12Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
12.12Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
12.12Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
12.12Single9AS9RS130-1809AS9-5-HT2A-RS130-180
12.12Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
12.12Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
12.12Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
12.12Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
12.12Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
12.12Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
12.12Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
12.12Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
12.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
11.76Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
11.76Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
11.76Single5CXVTiotropium5CXV-M1-Tiotropium
11.76Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
11.76Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
11.76Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
11.76Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
11.76Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
11.76Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single8XQJJN2418XQJ-Apelin-JN241
11.76Single8XWACXCL18XWA-CXCR2-CXCL1
11.76Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
11.76Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
11.76Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.76Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
11.76Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
11.76Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
11.54Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
11.54Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
11.54Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
11.54Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
11.54Single8PWNTheophylline8PWN-A2A-Theophylline
11.54Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
11.54Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
11.43Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
11.43Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
11.43Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
11.43Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.43Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.43Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
11.43Single8ZPLHF511168ZPL-CXCR4-HF51116
11.43Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
11.11Single3OE8IT1t3OE8-CXCR4-IT1t
11.11Single3RFMCaffeine3RFM-A2A-Caffeine
11.11Single6KNMJN241-96KNM-Apelin-JN241-9
11.11Single6TQ9SB-4081246TQ9-OX1-SB-408124
11.11Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
11.11Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
11.11Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
11.11Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
11.11Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
11.11Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
11.11Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
11.11Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
11.11Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
11.11Single9JF4PD1683689JF4-BB1-PD168368
11.11Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
11.11Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
11.11Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
11.11Consensuskisspeptin_onOrthosteric Ligandkiss1_on
11.11Consensusp2y_offOrthosteric Ligandp2y1_off
10.81Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
10.81Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.81Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.81Single8IEIA1LYA8IEI-GPR156-A1LYA
10.81Single8IEPA1LYA8IEP-GPR156-A1LYA
10.81Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
10.81Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
10.81Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
10.81Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.81Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.81Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
10.81Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
10.81Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
10.71Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
10.71Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
10.71Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
10.71Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
10.71Single6ME5Agomelatine6ME5-MT1-Agomelatine
10.71Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
10.71Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.71Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
10.71Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
10.71Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
10.71Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
10.71Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
10.71Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.71Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
10.71Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
10.71Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
10.71Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
10.71Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
10.71Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
10.71Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.71Consensusgi_sensoryOrthosteric Ligandgi_opsins
10.71Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
10.71Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.71Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.53Single8IEBA1LYA8IEB-GPR156-A1LYA
10.34Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
10.34Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
10.34Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
10.34Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
10.34Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
10.34Single3PBLEticlopride3PBL-D3-Eticlopride
10.34Single5L7IVismodegib5L7I-SMO-Vismodegib
10.34Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
10.34Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
10.34Single6HLLCP999946HLL-NK1-CP99994
10.34Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
10.34Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.34Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.34Single7UL2SR486927UL2-NTS1-SR48692-Na
10.34Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
10.34Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
10.34Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
10.34Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
10.34Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.34Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.34Single9AS7Psilocin9AS7-5-HT2A-Psilocin
10.34Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
10.34Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.34Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
10.34Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
10.34Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
10.34Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
10.34Consensusgq_nucleotideOrthosteric Ligandgq_p2y
10.34Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.34Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.34Consensusneurotensin_offOrthosteric Ligandnts1_off
10.34Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
10.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
10.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
10.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
10.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
10.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
10.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
10.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
10.00Single5WS3EMPA5WS3-OX2-EMPA
10.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
10.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
10.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
10.00Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
10.00Single6TODEMPA6TOD-OX1-EMPA-Na
10.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
10.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
10.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
10.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
10.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
10.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
10.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
10.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
10.00Single7XRRLemborexant7XRR-OX2-Lemborexant
10.00Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
10.00Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
10.00Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
10.00Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
10.00Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
10.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
10.00Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
10.00Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
10.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
10.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
10.00Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
10.00Single9H2XA1IR19H2X-A2A-A1IR1-Na
10.00Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
10.00Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
10.00Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
9.68Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
9.68Single3RZECidoxepin3RZE-H1-Cidoxepin
9.68Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
9.68Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
9.68Single6IQLL7458706IQL-D4-L745870
9.68Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
9.68Single6TP3Nemorexant6TP3-OX1-Nemorexant
9.68Single6TPNHTL66416TPN-OX2-HTL6641
9.68Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
9.68Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
9.68Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
9.68Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
9.68Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
9.68Single7VODCariprazine7VOD-5-HT2A-Cariprazine
9.68Single7VV6C48/807VV6-MRGPRX2-C48/80
9.68Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
9.68Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
9.68Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
9.68Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
9.68Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
9.68Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.68Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
9.68Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
9.68Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
9.68Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
9.68Single9ARXSerotonin9ARX-5-HT2A-Serotonin
9.68Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
9.68Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
9.38Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
9.38Single4QIMANTA XV4QIM-SMO-ANTA XV
9.38Single5DSGTiotropium5DSG-M4-Tiotropium
9.38Single6IIVDaltroban6IIV-TXA2-Daltroban
9.38Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.38Single7F83PF-051904577F83-Ghrelin-PF-05190457
9.38Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
9.38Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
9.38Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
9.38Single9IYAONO-97105319IYA-GPR55-ONO-9710531
9.38Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
9.09Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
9.09Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
9.09Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
9.09Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
9.09Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single7SINNPS-21437SIN-CaS-NPS-2143
9.09Single7SINNPS-21437SIN-CaS-NPS-2143
9.09Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
9.09Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
9.09Single9HAPTolvaptan9HAP-V2-Tolvaptan
9.09Single9HC04YI9HC0-mGlu5-4YI
9.09Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
8.82Single5TZRMK86665TZR-FFA1-MK8666
8.82Single6E59L-7607356E59-NK1-L-760735
8.82Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
8.82Single7P2L4YI7P2L-mGlu5-4YI
8.82Single7R0CAVP7R0C-V2-AVP-Arrestin2
8.82Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
8.82Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
8.82Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
8.82Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
8.82Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.82Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
8.82Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
8.82Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
8.82Single8XVLZibotentan8XVL-ETA-Zibotentan
8.82Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
8.82Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
8.82Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
8.82Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
8.82Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
8.82Consensustachykinin_offOrthosteric Ligandnk1_off
8.57Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
8.57Single4PY02MeSATP4PY0-P2Y12-2MeSATP
8.57Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
8.57Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
8.57Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
8.33Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
8.33Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
8.11Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
8.11Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single5MZPCaffeine5MZP-A2A-Caffeine-Na
7.69Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single7WC4Serotonin7WC4-5-HT2A-Serotonin
7.14Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
7.14Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
7.14Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
7.14Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
7.14Consensussensory_onOrthosteric Ligandopsins_on
6.90Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
6.90Single3UZAGTPL92363UZA-A2A-GTPL9236
6.90Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
6.90Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
6.90Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
6.90Single7WC5Psilocin7WC5-5-HT2A-Psilocin
6.90Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.90Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
6.90Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
6.90Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
6.90Single8JPSCCL78JPS-ACKR1-CCL7
6.90Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
6.90Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
6.90Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
6.90Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
6.90Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.90Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
6.67Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
6.67Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
6.67Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
6.67Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
6.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
6.67Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
6.67Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
6.67Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
6.67Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
6.67Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
6.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
6.67Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
6.67Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
6.45Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
6.45Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
6.45Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
6.45Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.45Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
6.45Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.45Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.45Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
6.45Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
6.25Single6FFIMMPEP6FFI-mGlu5-MMPEP
6.25Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
6.25Single6TPKRetosiban6TPK-OT-Retosiban
6.25Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
6.25Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
6.25Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
6.25Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
6.25Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
6.25Consensusvasop-oxy_offOrthosteric Ligandot_off
6.06Single6FFHFenobam6FFH-mGlu5-Fenobam
6.06Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
6.06Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
6.06Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.06Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
6.06Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
6.06Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
5.88Single4NTJAZD12834NTJ-P2Y12-AZD1283
5.88Single6HLPNetupitant6HLP-NK1-Netupitant
5.88Single6Z4SSR486926Z4S-NTS1-SR48692
5.88Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
5.88Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
5.88Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
5.88Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
5.88Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
5.71Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.56Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
5.56Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.56Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.56Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.56Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.41Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
5.41Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
5.26Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
5.26Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
5.13Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
4.17Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.17Single6D35Cholesterol6D35-SMO-Cholesterol
4.17Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.17Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.17Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
4.17Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
4.17Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
4.17Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
4.17Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
4.17Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
4.17Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
4.17Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
4.17Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
4.17Single7DTTCa7DTT-CaS-Ca-Ca
4.17Single7DTTCa7DTT-CaS-Ca-Ca
4.17Single7DTUTryptophan7DTU-CaS-Tryptophan
4.17Single7DTUTryptophan7DTU-CaS-Tryptophan
4.17Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.17Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.17Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.17Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.17Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.17Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.17Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.17Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.17Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
4.17Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.17Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.17Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.17Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.17Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.17Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.17Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
4.17Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
4.17Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.17Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.17Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.17Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.17Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.17Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.17Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.17Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.17Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.17Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.17Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.17Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.17Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.17Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
4.17Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.17Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.17Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.17Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.17Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.17Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.17Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
4.17Single7XW7K1-707XW7-TSH-K1-70
4.17Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.17Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.17Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.17Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.17Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.17Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.17Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.17Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.17Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.17Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.17Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.17Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.17Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
4.17Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.17Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.17Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.17Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.17Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
4.17Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
4.17Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.17Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.17Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
4.17Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
4.17Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
4.17Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
4.17Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.17Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.17Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
4.17Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.17Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.17Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.17Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.17Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.17Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.17Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.17Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.17Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.17Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.17Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.17Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.17Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.17Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.17Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.17Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.17Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
4.17Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
4.17Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
4.17Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
4.17Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
4.17Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
4.17Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.17Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.17Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single8WVXNorrin8WVX-LGR4-Norrin
4.17Single8WVYNorrin8WVY-LGR4-Norrin
4.17Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.17Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.17Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.17Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.17Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.17Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.17Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
4.17Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.17Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.17Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.17Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.17Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.17Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.17Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.17Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.17Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.17Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.17Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.17Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.17Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.17Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.17Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.17Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.17Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.17Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.17Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.17Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.17Single9KHHNorrin9KHH-LGR4-Norrin
4.17Single9S37NB219S37-LGR4-NB21
4.17Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
4.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.00Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
4.00Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
3.85Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
3.85Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
3.85Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
3.85Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
3.70Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
3.70Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
3.70Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
3.70Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
3.70Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
3.57Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
3.57Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
3.57Single5L7DCholesterol5L7D-SMO-Cholesterol
3.57Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
3.57Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
3.45Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
3.45Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
3.33Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
3.23Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
3.23Single6TP4ACT-4622066TP4-OX1-ACT-462206
3.23Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.23Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
3.23Single8HNNSCH5467388HNN-CXCR3-SCH546738
3.12Single4K5YCP-3763954K5Y-CRF1-CP-376395
3.12Single4XNVBPTU4XNV-P2Y1-BPTU
3.12Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
3.12Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
3.03Single6ZINSR486926ZIN-NTS1-SR48692
3.03Single8IYXYL-3658IYX-GPR34-YL-365
3.03Single8JD6VU03647708JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
2.94Single4Z9GCP-3763954Z9G-CRF1-CP-376395
2.94Single8GTIBMK-C2058GTI-CRF1-BMK-C205
2.86Single8GTGBMK-I1528GTG-CRF1-BMK-I152
2.78Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.70Single8GTMBMK-C2038GTM-CRF1-BMK-C203
2.63Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
2.50Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.50Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.38Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.38Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.33Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.17Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

PDB Summary
PDB 9BYO
Class B1
SubFamily Peptide
Type Glucagon
SubType GLP-1
Species Homo Sapiens
Ligand Exendin-3
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.31
Date 2025-06-11
D.O.I. To be published
Net Summary
Imin 3
Number of Linked Nodes 1005
Number of Links 1285
Number of Hubs 230
Number of Links mediated by Hubs 821
Number of Communities 25
Number of Nodes involved in Communities 333
Number of Links involved in Communities 513
Path Summary
Number Of Nodes in MetaPath 112
Number Of Links MetaPath 111
Number of Shortest Paths 9319911
Length Of Smallest Path 3
Average Path Length 44.803
Length of Longest Path 72
Minimum Path Strength 1.245
Average Path Strength 7.30442
Maximum Path Strength 27.49
Minimum Path Correlation 0.7
Average Path Correlation 0.997259
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.38095
Average % Of Corr. Nodes 44.2748
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.302
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • heart process   • multicellular organismal process   • system process   • regulation of biological process   • regulation of heart contraction   • regulation of system process   • circulatory system process   • regulation of blood circulation   • regulation of multicellular organismal process   • heart contraction   • blood circulation   • regulation of blood pressure   • positive regulation of blood pressure   • cellular response to stimulus   • regulation of cellular process   • response to stimulus   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to stress   • response to psychosocial stress   • cell surface receptor signaling pathway   • behavior   • learning or memory   • nervous system process   • cognition   • transport   • secretion   • regulation of hormone levels   • cell-cell signaling   • export from cell   • hormone secretion   • establishment of localization   • localization   • secretion by cell   • signal release   • hormone transport   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • establishment of protein localization   • cellular localization   • nitrogen compound transport   • protein targeting   • protein transmembrane transport   • establishment of localization in cell   • post-translational protein targeting to membrane, translocation   • intracellular protein localization   • establishment of protein localization to endoplasmic reticulum   • establishment of protein localization to membrane   • intracellular protein transmembrane transport   • intracellular transport   • post-translational protein targeting to endoplasmic reticulum membrane   • localization within membrane   • protein targeting to membrane   • transmembrane transport   • establishment of protein localization to organelle   • protein transport   • macromolecule localization   • intracellular protein transport   • protein targeting to ER   • negative regulation of blood pressure   • cellular anatomical structure   • membrane   • cell periphery   • plasma membrane   • hormone activity   • protein binding   • binding   • molecular function activator activity   • signaling receptor binding   • molecular function regulator activity   • signaling receptor regulator activity   • receptor ligand activity   • signaling receptor activator activity   • toxin activity   • extracellular region   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • developmental process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • sensory perception of chemical stimulus   • sensory perception   • sensory perception of smell   • cellular response to nitrogen compound   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • coagulation   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • regulation of localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • amide transport   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • regulation of protein transport   • protein secretion   • regulation of protein secretion   • regulation of secretion   • peptide transport   • regulation of insulin secretion   • peptide hormone secretion   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • synapse   • cell junction   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome
Gene OntologyCellular Component
SCOP2Domain Identifier• G protein-coupled receptor-like   • FnI-like domain   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• G protein-coupled receptor-like   • FnI-like domain   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP43220
Sequence
>9BYO_Chain_R
TVSLWETVQ KWREYRRQC QRSLTEDPP PATDLFCNR TFDEYACWP 
DGEPGSFVN VSCPWYLPW ASSVPQGHV YRFCTAEGL WLQKDNSSL 
PWRDLSECE ESSPEEQLL FLYIIYTVG YALSFSALV IASAILLGF 
RHLHCTRNY IHLNLFASF ILRALSVFI KDAALKWMY STAAQQHQW 
DGLLSYQDS LSCRLVFLL MQYCVAANY YWLLVEGVY LYTLLAFSV 
SEQWIFRLY VSIGWGVPL LFVVPWGIV KYLYEDEGC WTRNSNMNY 
WLIIRLPIL FAIGVNFLI FVRVICIVV SKLKANDIK CRLAKSTLT 
LIPLLGTHE VIFAFVMDE HARGTLRFI KLFTELSFT SFQGLMVAI 
LYCFVNNEV QLEFRKSWE RWRLEF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9BYO_Chain_A
DQRNEEKAQ REANKKIEK QLQKDKQVY RATHRLLLL GAGESGKTI 
VKQMRILHS GIFETKFQV DKVNFHMFD VGQRDERRK WIQCFNDVT 
AIIFVVASS SYNQTNRLQ ALLFSIWNN WLRSVILFL NKQDLLAEK 
VLAGKSKIE DYFPEFARY TTPEDATPE PGEDPRVTR AKYFIRDEF 
LRISTASGD GRHYCYPHF TCAVDTENI RRVFNDCRD IIQRMHLRQ 
YELNAAKDK DT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9BYO_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9BYO_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6ORVB1PeptideGlucagonGLP-1Homo sapiens-TT-OAD2Gs/β1/γ232020-01-08doi.org/10.1038/s41586-019-1902-z
6ORV (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-TT-OAD232020-01-08doi.org/10.1038/s41586-019-1902-z
7E14B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 156022738Gs/β1/γ22.92021-07-07doi.org/10.1038/s41467-021-24058-z
7E14 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 1560227382.92021-07-07doi.org/10.1038/s41467-021-24058-z
7DUQB1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 156022738Gs/β1/γ22.52021-07-14doi.org/10.1038/s41467-021-24058-z
7DUQ (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 1560227382.52021-07-14doi.org/10.1038/s41467-021-24058-z
7DURB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ23.32021-08-11doi.org/10.1038/s41467-021-24058-z
7DUR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227383.32021-08-11doi.org/10.1038/s41467-021-24058-z
7EVMB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ22.52021-08-11doi.org/10.1038/s41467-021-24058-z
7EVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227382.52021-08-11doi.org/10.1038/s41467-021-24058-z
5VEWB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.72017-05-24doi.org/10.1038/nature22378
6LN2B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-3.22020-03-18doi.org/10.1038/s41467-020-14934-5
6KJVB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.82019-11-13doi.org/10.1107/S2052252519013496
6KK1B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.82019-11-13doi.org/10.1107/S2052252519013496
6KK7B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-3.12019-11-13doi.org/10.1107/S2052252519013496
5VEXB1PeptideGlucagonGLP-1Homo sapiens-NNC0640-32017-05-17doi.org/10.1038/nature22378
9IVMB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN3318839chim(NtGi1-Gs)/β2/γ23.222024-11-13doi.org/10.1016/j.apsb.2024.09.002
9IVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN33188393.222024-11-13doi.org/10.1016/j.apsb.2024.09.002
6VCBB1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN3160440Gs/β1/γ23.32020-07-22doi.org/10.1038/s41589-020-0589-7
6VCB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN31604403.32020-07-22doi.org/10.1038/s41589-020-0589-7
9IVGB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ232024-11-27doi.org/10.1016/j.apsb.2024.09.002
9IVG (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-32024-11-27doi.org/10.1016/j.apsb.2024.09.002
7RTBB1PeptideGlucagonGLP-1Homo sapiensPeptide-19-Gs/β1/γ22.142021-10-06doi.org/10.1016/j.bbrc.2021.09.016
7RTB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-19-2.142021-10-06doi.org/10.1016/j.bbrc.2021.09.016
7KI0B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-Gs/β1/γ22.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI0 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-2.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI1B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-Gs/β1/γ22.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI1 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-2.52021-08-04doi.org/10.1016/j.celrep.2021.109374
6X18B1PeptideGlucagonGLP-1Homo sapiensGLP-1-Gs/β1/γ22.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X18 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1-2.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X19B1PeptideGlucagonGLP-1Homo sapiensCHU-128-Gs/β1/γ22.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X19 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensCHU-128-2.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X1AB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.52020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X1A (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.52020-09-09doi.org/10.1016/j.molcel.2020.09.020
7LCIB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.92021-01-20doi.org/10.1016/j.str.2021.04.008
7LCI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.92021-01-20doi.org/10.1016/j.str.2021.04.008
7LCJB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--2.822021-01-20doi.org/10.1016/j.str.2021.04.008
7LCKB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--3.242021-01-20doi.org/10.1016/j.str.2021.04.008
7S15B1PeptideGlucagonGLP-1Homo sapiensPubChem 134611223--3.82022-06-08doi.org/10.1021/acs.jmedchem.1c01856
9J1PB1PeptideGlucagonGLP-1Homo sapiensg1:Ox-chim(NtGi1-Gs)/β1/γ22.992025-02-26doi.org/10.1021/jacs.4c12808
9J1P (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensg1:Ox-2.992025-02-26doi.org/10.1021/jacs.4c12808
5VAIB1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-Gs/β1/γ24.12017-05-24doi.org/10.1038/nature22394
5VAI (No Gprot) B1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-4.12017-05-24doi.org/10.1038/nature22394
5NX2B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)--3.72017-06-14doi.org/10.1038/nature22800
6B3JB1PeptideGlucagonGLP-1Homo sapiensExendin-P5-Gs/β1/γ23.32018-02-21doi.org/10.1038/nature25773
6B3J (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-P5-3.32018-02-21doi.org/10.1038/nature25773
8WG7B1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.542024-03-06doi.org/10.1038/s41421-024-00649-0
8WG7 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.542024-03-06doi.org/10.1038/s41421-024-00649-0
7C2EB1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-Gs/β1/γ24.22020-08-26doi.org/10.1038/s41422-020-0384-8
7C2E (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-4.22020-08-26doi.org/10.1038/s41422-020-0384-8
7LLLB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ23.72022-01-12doi.org/10.1038/s41467-021-27760-0
7LLL (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-3.72022-01-12doi.org/10.1038/s41467-021-27760-0
7LLYB1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-Gs/β1/γ23.32022-01-12doi.org/10.1038/s41467-021-27760-0
7LLY (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-3.32022-01-12doi.org/10.1038/s41467-021-27760-0
7FIMB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-Gs/β1/γ23.42022-03-02doi.org/10.1038/s41467-022-28683-0
7FIM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-3.42022-03-02doi.org/10.1038/s41467-022-28683-0
7VBIB1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-Gs/β1/γ232022-03-02doi.org/10.1038/s41467-022-28683-0
7VBI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-32022-03-02doi.org/10.1038/s41467-022-28683-0
7VBHB1PeptideGlucagonGLP-1Homo sapiensPeptide-20-Gs/β1/γ232022-04-06doi.org/10.1038/s41467-022-28683-0
7VBH (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-20-32022-04-06doi.org/10.1038/s41467-022-28683-0
7S1MB1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-Gs/β1/γ22.412022-01-05doi.org/10.1038/s41589-021-00945-w
7S1M (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-2.412022-01-05doi.org/10.1038/s41589-021-00945-w
7S3IB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.512022-01-05doi.org/10.1038/s41589-021-00945-w
7S3I (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.512022-01-05doi.org/10.1038/s41589-021-00945-w
6XOXB1PeptideGlucagonGLP-1Homo sapiensOrforglipron-chim(NtGi1-Gs)/β1/γ23.12020-11-18doi.org/10.1073/pnas.2014879117
6XOX (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipron-3.12020-11-18doi.org/10.1073/pnas.2014879117
7RG9B1PeptideGlucagonGLP-1Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22022-04-13doi.org/10.1073/pnas.2116506119
7RG9 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.22022-04-13doi.org/10.1073/pnas.2116506119
7RGPB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-chim(NtGi1-Gs)/β1/γ22.92022-04-13doi.org/10.1073/pnas.2116506119
7RGP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-2.92022-04-13doi.org/10.1073/pnas.2116506119
7X8RB1PeptideGlucagonGLP-1Homo sapiensBOC5-Gs/β1/γ22.612022-06-29doi.org/10.1073/pnas.2200155119
7X8R (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensBOC5-2.612022-06-29doi.org/10.1073/pnas.2200155119
7X8SB1PeptideGlucagonGLP-1Homo sapiensWB4-24-Gs/β1/γ23.092022-06-29doi.org/10.1073/pnas.2200155119
7X8S (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensWB4-24-3.092022-06-29doi.org/10.1073/pnas.2200155119
8JIPB1PeptideGlucagonGLP-1Homo sapiensMEDI0382-chim(NtGi1-Gs)/β1/γ22.852023-09-06doi.org/10.1073/pnas.2303696120
8JIP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensMEDI0382-2.852023-09-06doi.org/10.1073/pnas.2303696120
8JIRB1PeptideGlucagonGLP-1Homo sapiensSAR425899-chim(NtGi1-Gs)/β1/γ22.572023-09-06doi.org/10.1073/pnas.2303696120
8JIR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSAR425899-2.572023-09-06doi.org/10.1073/pnas.2303696120
8JISB1PeptideGlucagonGLP-1Homo sapiensPeptide-15-chim(NtGi1-Gs)/β1/γ22.462023-11-08doi.org/10.1073/pnas.2303696120
8JIS (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-15-2.462023-11-08doi.org/10.1073/pnas.2303696120
8YW3B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-Gs/β1/γ22.682024-09-18doi.org/10.1038/s41421-024-00700-0
8YW3 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-2.682024-09-18doi.org/10.1038/s41421-024-00700-0
9EBNB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ23.442025-03-26doi.org/10.1073/pnas.2407574122
9EBN (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.442025-03-26doi.org/10.1073/pnas.2407574122
9EBOB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (ACPC18)-Gs/β1/γ23.132025-03-26doi.org/10.1073/pnas.2407574122
9EBO (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (ACPC18)-3.132025-03-26doi.org/10.1073/pnas.2407574122
9EBQB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ23.162025-03-26doi.org/10.1073/pnas.2407574122
9EBQ (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.162025-03-26doi.org/10.1073/pnas.2407574122
8YWFB1PeptideGlucagonGLP-1Homo sapiensRetatrutide-chim(NtGi1-Gs)/β1/γ22.742025-04-16To be published
8YWF (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-2.742025-04-16To be published
9BYOB1PeptideGlucagonGLP-1Homo sapiensExendin-3-Gs/β1/γ22.312025-06-11To be published
9BYO (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-3-2.312025-06-11To be published
9C0KB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ22.722025-06-11To be published
9C0K (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-2.722025-06-11To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9BYO.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.