psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:K16	R:R:V30	6.07	No	No	0	0	2
2	R:R:R299	R:R:S31	7.91	Yes	No	0	4	4
3	R:R:L32	R:R:Q213	6.65	No	No	0	4	4
4	R:R:L32	R:R:W214	3.42	No	Yes	1	4	1
5	L:L:F22	R:R:L32	3.65	No	No	1	0	4
6	R:R:E34	R:R:W33	8.72	No	No	0	4	3
7	R:R:Q37	R:R:W33	20.81	No	No	0	4	3
8	L:L:Q19	R:R:T35	7.09	No	No	0	0	5
9	R:R:E41	R:R:K38	4.05	No	No	0	4	4
10	R:R:K38	R:R:Y88	3.58	No	Yes	0	4	5
11	R:R:R43	R:R:W39	9	No	Yes	0	4	5
12	R:R:W39	R:R:Y88	16.4	Yes	Yes	1	5	5
13	L:L:L26	R:R:W39	7.97	Yes	Yes	1	0	5
14	R:R:G216	R:R:R40	4.5	No	No	0	2	2
15	R:R:E41	R:R:W87	6.54	No	No	0	4	3
16	R:R:Q45	R:R:Y42	4.51	No	Yes	0	5	6
17	R:R:C71	R:R:Y42	4.03	No	Yes	0	9	6
18	R:R:P86	R:R:Y42	9.74	No	Yes	1	8	6
19	R:R:W87	R:R:Y42	7.72	No	Yes	0	3	6
20	R:R:Y42	R:R:Y88	7.94	Yes	Yes	1	6	5
21	R:R:F66	R:R:R43	8.55	No	No	0	7	4
22	R:R:C46	R:R:C71	7.28	No	No	0	8	9
23	R:R:E52	R:R:S49	5.75	No	No	0	2	2
24	R:R:L50	R:R:R64	8.5	No	No	0	4	4
25	R:R:D53	R:R:E52	7.8	No	No	0	3	2
26	R:R:P54	R:R:P56	3.9	No	No	7	2	1
27	R:R:D74	R:R:P55	11.27	No	Yes	0	3	1
28	R:R:F61	R:R:T58	15.56	No	No	8	3	1
29	R:R:P77	R:R:T58	8.74	No	No	8	4	1
30	R:R:D59	R:R:L60	6.79	No	No	0	3	1
31	R:R:F61	R:R:P77	14.45	No	No	8	3	4
32	R:R:F61	R:R:G108	6.02	No	No	0	3	9
33	R:R:C62	R:R:G75	3.92	No	No	0	9	7
34	R:R:C104	R:R:C62	7.28	No	No	1	9	9
35	R:R:C62	R:R:W110	6.53	No	Yes	1	9	9
36	R:R:N63	R:R:R64	3.62	No	No	0	4	4
37	R:R:D74	R:R:R64	3.57	No	No	0	3	4
38	R:R:T65	R:R:W72	4.85	No	Yes	1	5	9
39	R:R:T65	R:R:W110	6.06	No	Yes	1	5	9
40	R:R:C71	R:R:F66	8.38	No	No	0	9	7
41	R:R:D67	R:R:W72	6.7	No	Yes	0	9	9
42	L:L:L26	R:R:E68	3.98	Yes	No	0	0	4
43	L:L:G29	R:R:E68	4.91	No	No	0	0	4
44	R:R:C85	R:R:Y69	5.38	No	Yes	0	9	6
45	R:R:Y69	R:R:Y88	3.97	Yes	Yes	1	6	5
46	R:R:L89	R:R:Y69	9.38	No	Yes	0	5	6
47	R:R:R121	R:R:Y69	5.14	Yes	Yes	1	6	6
48	R:R:L123	R:R:Y69	4.69	No	Yes	1	5	6
49	L:L:I27	R:R:Y69	6.04	No	Yes	1	0	6
50	R:R:V83	R:R:W72	3.68	No	Yes	1	5	9
51	R:R:R102	R:R:W72	13.99	Yes	Yes	1	8	9
52	R:R:W110	R:R:W72	7.5	Yes	Yes	1	9	9
53	R:R:D74	R:R:G75	3.35	No	No	0	3	7
54	R:R:E76	R:R:P77	4.72	No	No	0	1	4
55	R:R:F80	R:R:Y101	5.16	No	No	9	4	5
56	R:R:F103	R:R:F80	7.5	Yes	No	9	4	4
57	R:R:H99	R:R:N82	22.96	No	No	0	4	4
58	R:R:N82	R:R:Y101	18.61	No	No	0	4	5
59	R:R:R102	R:R:V83	9.15	Yes	No	1	8	5
60	R:R:C126	R:R:C85	5.46	No	No	0	9	9
61	R:R:P86	R:R:Y88	6.95	No	Yes	1	8	5
62	L:L:L26	R:R:Y88	7.03	Yes	Yes	1	0	5
63	R:R:L89	R:R:W91	5.69	No	Yes	0	5	4
64	R:R:P90	R:R:W91	10.81	No	Yes	0	4	4
65	L:L:Q19	R:R:P90	7.9	No	No	0	0	4
66	R:R:E128	R:R:W91	23.99	No	Yes	0	3	4
67	L:L:V23	R:R:W91	7.36	No	Yes	0	0	4
68	R:R:S94	R:R:V95	4.85	No	No	0	4	5
69	R:R:P96	R:R:V95	3.53	No	No	0	3	5
70	R:R:C126	R:R:V95	3.42	No	No	0	9	5
71	R:R:R102	R:R:V100	13.08	Yes	No	0	8	7
72	R:R:E125	R:R:V100	5.7	No	No	0	5	7
73	R:R:F103	R:R:Y101	12.38	Yes	No	9	4	5
74	R:R:R102	R:R:R121	3.2	Yes	Yes	1	8	6
75	R:R:F103	R:R:W120	20.04	Yes	No	0	4	5
76	R:R:D122	R:R:F103	9.55	No	Yes	0	7	4
77	R:R:C104	R:R:W110	15.67	No	Yes	1	9	9
78	R:R:E107	R:R:T105	7.06	No	No	0	5	4
79	R:R:L111	R:R:T105	4.42	No	No	0	4	4
80	R:R:L109	R:R:W110	3.42	No	Yes	0	5	9
81	R:R:P119	R:R:W110	8.11	No	Yes	0	6	9
82	R:R:L111	R:R:W120	5.69	No	No	0	4	5
83	R:R:K113	R:R:S116	7.65	No	No	0	4	5
84	R:R:K113	R:R:L118	11.28	No	No	0	4	4
85	R:R:K113	R:R:W120	4.64	No	No	0	4	5
86	R:R:L118	R:R:P119	4.93	No	No	0	4	6
87	R:R:L123	R:R:R121	10.93	No	Yes	1	5	6
88	L:L:I27	R:R:R121	5.01	No	Yes	1	0	6
89	R:R:D122	R:R:S124	4.42	No	No	0	7	5
90	R:R:E127	R:R:E128	15.22	No	No	0	2	3
91	L:L:K20	R:R:E128	4.05	No	No	0	0	3
92	R:R:E138	R:R:E139	3.81	No	No	0	2	2
93	R:R:E138	R:R:Q140	5.1	No	No	0	2	4
94	R:R:F381	R:R:Q140	7.03	Yes	No	0	4	4
95	L:L:F6	R:R:L141	3.65	Yes	No	4	0	5
96	L:L:Y10	R:R:L141	9.38	Yes	No	4	0	5
97	R:R:F381	R:R:L144	4.87	Yes	No	0	4	6
98	R:R:F385	R:R:L144	3.65	No	No	0	6	6
99	R:R:Y145	R:R:Y148	3.97	Yes	No	0	5	7
100	R:R:D198	R:R:Y145	6.9	No	Yes	0	7	5
101	R:R:K202	R:R:Y145	3.58	No	Yes	0	4	5
102	L:L:F6	R:R:Y148	10.32	Yes	No	0	0	7
103	R:R:G151	R:R:S392	3.71	No	No	0	8	9
104	R:R:R190	R:R:Y152	5.14	Yes	Yes	2	8	7
105	R:R:V194	R:R:Y152	8.83	No	Yes	2	7	7
106	R:R:T391	R:R:Y152	3.75	Yes	Yes	2	6	7
107	L:L:E3	R:R:Y152	4.49	Yes	Yes	2	0	7
108	R:R:L154	R:R:L396	4.15	No	No	0	5	7
109	R:R:G395	R:R:S155	3.71	No	No	0	9	9
110	R:R:F156	R:R:I188	5.02	No	No	0	7	7
111	R:R:F184	R:R:L159	4.87	No	Yes	0	8	9
112	R:R:I188	R:R:L159	4.28	No	Yes	0	7	9
113	R:R:G395	R:R:L159	5.13	No	Yes	0	9	9
114	R:R:A162	R:R:C403	3.61	No	No	0	9	9
115	R:R:L166	R:R:L172	4.15	No	No	0	8	9
116	R:R:C403	R:R:L166	4.76	No	No	0	9	8
117	R:R:L167	R:R:L181	4.15	No	No	0	3	6
118	R:R:E412	R:R:F169	17.49	No	No	0	8	7
119	R:R:F169	R:R:F413	6.43	No	No	0	7	5
120	R:R:H173	R:R:R170	10.16	No	No	0	7	8
121	R:R:E412	R:R:H171	7.39	No	No	0	8	7
122	R:R:L172	R:R:N177	12.36	No	No	0	9	9
123	R:R:H173	R:R:Y178	7.62	No	No	0	7	6
124	R:R:C174	R:R:N177	4.72	No	No	0	8	9
125	R:R:F266	R:R:T175	3.89	No	No	0	6	7
126	R:R:E247	R:R:I179	4.1	No	No	0	9	8
127	R:R:I179	R:R:Y250	8.46	No	No	0	8	8
128	R:R:E247	R:R:H180	9.85	No	No	0	9	9
129	R:R:H180	R:R:Y402	7.62	No	Yes	0	9	8
130	R:R:N182	R:R:W243	13.56	No	Yes	6	9	9
131	R:R:N182	R:R:W274	10.17	No	Yes	6	9	9
132	R:R:F187	R:R:L183	7.31	Yes	No	0	8	9
133	R:R:F184	R:R:V398	3.93	No	No	0	8	9
134	R:R:C403	R:R:F184	4.19	No	No	0	9	8
135	R:R:N240	R:R:S186	5.96	No	No	0	9	9
136	R:R:S186	R:R:W243	4.94	No	Yes	6	9	9
137	R:R:S186	R:R:W274	4.94	No	Yes	6	9	9
138	R:R:F187	R:R:N240	14.5	Yes	No	0	8	9
139	R:R:F187	R:R:Q394	5.86	Yes	Yes	0	8	9
140	R:R:F187	R:R:V398	3.93	Yes	No	0	8	9
141	R:R:C236	R:R:L189	4.76	No	No	0	5	7
142	R:R:L189	R:R:W274	7.97	No	Yes	0	7	9
143	R:R:R190	R:R:V237	6.54	Yes	No	2	8	6
144	R:R:N240	R:R:R190	9.64	No	Yes	0	9	8
145	R:R:R190	R:R:Y241	4.12	Yes	No	0	8	8
146	R:R:R190	R:R:T391	3.88	Yes	Yes	2	8	6
147	L:L:E3	R:R:R190	9.3	Yes	Yes	2	0	8
148	R:R:M233	R:R:S193	7.67	No	No	0	6	6
149	R:R:C236	R:R:S193	6.89	No	No	0	5	6
150	L:L:E3	R:R:V194	4.28	Yes	No	2	0	7
151	R:R:D198	R:R:F195	3.58	No	No	0	7	7
152	R:R:F230	R:R:K197	6.2	No	No	0	5	6
153	R:R:K197	R:R:M233	12.96	No	No	0	6	6
154	L:L:T7	R:R:K197	6.01	No	No	0	0	6
155	R:R:A200	R:R:V229	3.39	No	No	0	4	7
156	L:L:Y10	R:R:L201	3.52	Yes	No	0	0	7
157	R:R:M204	R:R:Y205	13.17	No	No	0	3	3
158	R:R:M204	R:R:Y220	7.18	No	No	0	3	3
159	R:R:M204	R:R:Q221	4.08	No	No	0	3	4
160	L:L:L14	R:R:Y205	5.86	No	No	0	0	3
161	R:R:Q210	R:R:W214	12.05	No	Yes	0	4	1
162	L:L:A18	R:R:Q210	4.55	No	No	0	0	4
163	R:R:Q211	R:R:W214	9.86	No	Yes	1	4	1
164	L:L:W25	R:R:Q211	3.29	No	No	1	0	4
165	L:L:F22	R:R:W214	16.04	No	Yes	1	0	1
166	L:L:W25	R:R:W214	14.06	No	Yes	1	0	1
167	R:R:L217	R:R:L218	4.15	No	No	0	4	3
168	R:R:Q221	R:R:S219	8.66	No	No	10	4	5
169	R:R:D222	R:R:S219	7.36	No	No	10	6	5
170	R:R:C226	R:R:Y220	8.06	No	No	0	9	3
171	R:R:D222	R:R:Q221	5.22	No	No	10	6	4
172	R:R:C226	R:R:C296	7.28	No	No	0	9	9
173	R:R:R227	R:R:W297	19.99	No	Yes	0	8	8
174	R:R:F230	R:R:V229	3.93	No	No	0	5	7
175	R:R:F230	R:R:T298	7.78	No	No	0	5	5
176	R:R:G285	R:R:L231	3.42	No	No	0	5	5
177	R:R:L231	R:R:W297	4.56	No	Yes	0	5	8
178	L:L:E3	R:R:M233	4.06	Yes	No	0	0	6
179	R:R:Q234	R:R:W284	5.48	No	Yes	0	7	8
180	L:L:Y1	R:R:Q234	13.53	No	No	0	0	7
181	R:R:W274	R:R:Y235	3.86	Yes	No	0	9	9
182	R:R:L278	R:R:Y235	4.69	No	No	0	3	9
183	R:R:V281	R:R:Y235	5.05	No	No	0	6	9
184	L:L:Y1	R:R:V237	10.09	No	No	0	0	6
185	L:L:E3	R:R:V237	5.7	Yes	No	2	0	6
186	R:R:I313	R:R:Y241	8.46	No	No	0	7	8
187	R:R:E364	R:R:Y241	6.73	Yes	No	0	8	8
188	R:R:V276	R:R:Y242	5.05	No	Yes	5	3	6
189	R:R:P277	R:R:Y242	12.52	Yes	Yes	5	9	6
190	R:R:F280	R:R:Y242	5.16	No	Yes	5	5	6
191	R:R:P312	R:R:Y242	5.56	No	Yes	5	8	6
192	R:R:V246	R:R:W243	8.58	No	Yes	0	8	9
193	R:R:G273	R:R:W243	9.85	No	Yes	0	9	9
194	R:R:W243	R:R:W274	18.74	Yes	Yes	6	9	9
195	R:R:V246	R:R:Y269	6.31	No	Yes	0	8	7
196	R:R:V249	R:R:Y269	6.31	No	Yes	0	6	7
197	R:R:L254	R:R:Y250	15.24	No	No	0	8	8
198	R:R:Y250	R:R:Y269	5.96	No	Yes	0	8	7
199	R:R:A256	R:R:Y252	9.34	No	No	0	6	8
200	R:R:F257	R:R:Y252	6.19	No	No	0	5	8
201	R:R:F257	R:R:T253	6.49	No	No	0	5	7
202	R:R:I265	R:R:L260	4.28	No	No	0	5	7
203	R:R:I265	R:R:W264	3.52	No	No	0	5	5
204	R:R:F266	R:R:V270	5.24	No	No	0	6	5
205	R:R:R267	R:R:V270	5.23	No	No	0	4	5
206	R:R:I272	R:R:L268	4.28	No	No	0	6	2
207	R:R:P277	R:R:V276	3.53	Yes	No	5	9	3
208	R:R:F280	R:R:P312	17.34	No	No	5	5	8
209	R:R:P283	R:R:V282	5.3	No	No	0	5	3
210	R:R:K288	R:R:W284	13.92	No	Yes	3	8	8
211	R:R:W284	R:R:W297	3.75	Yes	Yes	3	8	8
212	R:R:I308	R:R:W284	4.7	No	Yes	0	8	8
213	R:R:I309	R:R:W284	11.74	No	Yes	0	7	8
214	R:R:V287	R:R:Y291	3.79	No	Yes	3	4	3
215	R:R:V287	R:R:Y305	3.79	No	Yes	3	4	4
216	R:R:E292	R:R:K288	9.45	Yes	No	3	6	8
217	R:R:K288	R:R:W297	20.89	No	Yes	3	8	8
218	R:R:E292	R:R:Y291	3.37	Yes	Yes	3	6	3
219	R:R:Y291	R:R:Y305	11.91	Yes	Yes	3	3	4
220	R:R:E292	R:R:E294	5.07	Yes	No	0	6	4
221	R:R:E292	R:R:S301	5.75	Yes	No	0	6	3
222	R:R:E292	R:R:Y305	7.86	Yes	Yes	3	6	4
223	R:R:G295	R:R:R299	4.5	No	Yes	0	4	4
224	L:L:S11	R:R:T298	6.4	No	No	0	0	5
225	L:L:S11	R:R:R299	3.95	No	Yes	0	0	4
226	L:L:I12	R:R:R299	3.76	No	Yes	0	0	4
227	L:L:D15	R:R:R299	3.57	No	Yes	0	0	4
228	R:R:N300	R:R:W306	11.3	No	Yes	0	6	6
229	L:L:S8	R:R:N300	4.47	No	No	0	0	6
230	R:R:N302	R:R:S301	4.47	No	No	0	5	3
231	R:R:N302	R:R:Y305	12.79	No	Yes	0	5	4
232	R:R:E373	R:R:M303	6.77	Yes	No	0	4	5
233	R:R:I309	R:R:W306	3.52	No	Yes	0	7	6
234	R:R:D372	R:R:W306	5.58	No	Yes	0	5	6
235	L:L:T5	R:R:W306	4.85	No	Yes	0	0	6
236	R:R:L307	R:R:R310	4.86	No	Yes	0	7	6
237	R:R:L314	R:R:R310	3.64	No	Yes	0	4	6
238	R:R:M371	R:R:R310	4.96	Yes	Yes	11	7	6
239	R:R:E373	R:R:R310	4.65	Yes	Yes	11	4	6
240	R:R:L311	R:R:P312	4.93	No	No	0	4	8
241	R:R:L360	R:R:N320	5.49	Yes	No	0	9	9
242	R:R:F321	R:R:V365	15.73	No	No	0	6	6
243	R:R:F324	R:R:I328	3.77	No	No	0	9	7
244	R:R:F324	R:R:T362	19.46	No	No	0	9	7
245	R:R:R326	R:R:V325	3.92	No	No	0	8	5
246	R:R:D344	R:R:I345	8.4	No	No	0	7	5
247	R:R:K346	R:R:L349	4.23	No	Yes	0	6	9
248	R:R:C347	R:R:K351	3.23	No	No	0	7	8
249	R:R:K351	R:R:R348	13.61	No	No	0	8	8
250	R:R:R348	R:R:S352	3.95	No	Yes	0	8	9
251	R:R:L349	R:R:S352	4.5	Yes	Yes	0	9	9
252	R:R:L401	R:R:T355	4.42	Yes	No	0	8	8
253	R:R:L356	R:R:Y402	4.69	No	Yes	0	9	8
254	R:R:I357	R:R:P358	5.08	No	No	0	8	9
255	R:R:I357	R:R:T362	4.56	No	No	0	8	7
256	R:R:M397	R:R:P358	6.71	No	No	0	5	9
257	R:R:L401	R:R:P358	3.28	Yes	No	0	8	9
258	R:R:L359	R:R:Y402	12.89	No	Yes	0	9	8
259	R:R:E364	R:R:H363	18.46	Yes	Yes	2	8	8
260	R:R:F390	R:R:H363	5.66	No	Yes	0	6	8
261	R:R:H363	R:R:Q394	9.89	Yes	Yes	2	8	9
262	R:R:E364	R:R:T391	4.23	Yes	Yes	2	8	6
263	R:R:E364	R:R:Q394	6.37	Yes	Yes	2	8	9
264	R:R:F367	R:R:I366	5.02	Yes	No	0	7	6
265	R:R:F367	R:R:K383	11.17	Yes	No	0	7	7
266	R:R:F367	R:R:T386	6.49	Yes	No	2	7	4
267	R:R:E387	R:R:F367	11.66	Yes	Yes	2	8	7
268	R:R:K383	R:R:V370	10.62	No	No	0	7	5
269	R:R:E373	R:R:M371	5.41	Yes	Yes	11	4	7
270	R:R:H374	R:R:M371	6.57	No	Yes	0	3	7
271	R:R:D372	R:R:E373	7.8	No	Yes	0	5	4
272	R:R:L384	R:R:R380	3.64	No	No	4	5	5
273	L:L:D9	R:R:R380	4.76	No	No	4	0	5
274	R:R:F381	R:R:I382	3.77	Yes	No	0	4	4
275	L:L:F6	R:R:L384	6.09	Yes	No	4	0	5
276	L:L:D9	R:R:L384	5.43	No	No	4	0	5
277	R:R:F385	R:R:S389	5.28	No	No	0	6	5
278	R:R:E387	R:R:T386	5.64	Yes	No	2	8	4
279	L:L:?2	R:R:L388	3.98	Yes	No	0	0	7
280	L:L:F6	R:R:L388	4.87	Yes	No	0	0	7
281	R:R:F390	R:R:S389	3.96	No	No	0	6	5
282	R:R:Q394	R:R:T391	5.67	Yes	Yes	2	9	6
283	R:R:F393	R:R:S392	10.57	No	No	0	7	9
284	R:R:F393	R:R:L396	4.87	No	No	0	7	7
285	R:R:F404	R:R:I400	3.77	No	No	0	8	6
286	R:R:L401	R:R:Y402	3.52	Yes	Yes	0	8	8
287	R:R:E408	R:R:N406	11.83	No	No	0	9	9
288	R:R:N406	R:R:V409	4.43	No	No	0	9	9
289	R:R:N407	R:R:Q410	3.96	No	No	0	6	7
290	R:R:E412	R:R:K415	8.1	No	No	0	8	7
291	R:R:K415	R:R:R419	13.61	No	No	0	7	7
292	R:R:E418	R:R:W417	5.45	No	No	0	4	5
293	L:L:?2	L:L:E3	3.81	Yes	Yes	0	0	0
294	L:L:?2	L:L:T5	8.47	Yes	No	0	0	0
295	L:L:G4	L:L:T7	3.64	No	No	0	0	0
296	L:L:F6	L:L:Y10	9.28	Yes	Yes	4	0	0
297	L:L:L14	L:L:Y10	4.69	No	Yes	0	0	0
298	L:L:?13	L:L:I12	5.47	No	No	0	0	0
299	L:L:?13	L:L:L14	3.98	No	No	0	0	0
300	L:L:?13	L:L:I17	5.47	No	No	0	0	0
301	L:L:D15	L:L:K16	6.91	No	No	0	0	0
302	L:L:K16	L:L:Q19	9.49	No	No	0	0	0
303	L:L:F22	L:L:L26	3.65	No	Yes	1	0	0
304	R:R:G361	R:R:H363	3.18	No	Yes	0	9	8
305	R:R:C236	R:R:L232	3.17	No	No	0	5	5
306	R:R:A399	R:R:L159	3.15	No	Yes	0	8	9
307	R:R:E76	R:R:P55	3.14	No	Yes	0	1	1
308	R:R:F266	R:R:Y178	3.09	No	No	0	6	6
309	R:R:I272	R:R:V246	3.07	No	No	0	6	8
310	R:R:I317	R:R:V365	3.07	No	No	0	7	6
311	R:R:I179	R:R:T175	3.04	No	No	0	8	7
312	R:R:I328	R:R:T353	3.04	No	No	0	7	9
313	R:R:L154	R:R:S157	3	No	No	0	5	3
314	R:R:R414	R:R:W417	3	No	No	0	6	5
315	R:R:L251	R:R:V327	2.98	No	No	0	9	9
316	R:R:L349	R:R:V332	2.98	Yes	No	0	9	6
317	R:R:I146	R:R:I147	2.94	No	No	0	4	6
318	R:R:I400	R:R:M397	2.92	No	No	0	6	5
319	R:R:I330	R:R:K334	2.91	No	No	0	9	9
320	R:R:Q112	R:R:S117	2.89	No	No	0	3	7
321	R:R:W297	R:R:Y289	2.89	Yes	No	0	8	3
322	R:R:E34	R:R:S31	2.87	No	No	0	4	4
323	R:R:E76	R:R:S79	2.87	No	No	0	1	5
324	R:R:I286	R:R:L290	2.85	No	No	0	4	3
325	R:R:Q210	R:R:T207	2.83	No	No	0	4	3
326	R:R:M303	R:R:N304	2.8	No	No	0	5	3
327	R:R:C174	R:R:R176	2.79	No	No	0	8	9
328	R:R:A70	R:R:R102	2.77	No	Yes	0	5	8
329	R:R:L183	R:R:L244	2.77	No	No	0	9	9
330	R:R:L224	R:R:L228	2.77	No	No	0	3	4
331	R:R:A238	R:R:F280	2.77	No	No	0	6	5
332	R:R:L251	R:R:L255	2.77	No	No	0	9	8
333	R:R:L335	R:R:L349	2.77	No	Yes	0	8	9
334	R:R:L356	R:R:L360	2.77	No	Yes	0	9	9
335	R:R:L359	R:R:L360	2.77	No	Yes	0	9	9
336	R:R:A375	R:R:R380	2.77	No	No	0	4	5
337	R:R:D114	R:R:N115	2.69	No	No	0	4	4
338	R:R:A316	R:R:Y242	2.67	No	Yes	0	7	6
339	R:R:L109	R:R:Q112	2.66	No	No	0	5	3
340	R:R:F413	R:R:V409	2.62	No	No	0	5	9
341	R:R:F195	R:R:T149	2.59	No	No	0	7	7
342	R:R:A239	R:R:W274	2.59	No	Yes	0	8	9
343	R:R:F321	R:R:T362	2.59	No	No	0	6	7
344	R:R:F381	R:R:T378	2.59	Yes	No	0	4	2
345	R:R:S392	R:R:Y152	2.54	No	Yes	0	9	7
346	R:R:E364	R:R:E387	2.54	Yes	Yes	2	8	8
347	L:L:?2	R:R:E387	2.54	Yes	Yes	0	0	8
348	R:R:F404	R:R:I161	2.51	No	No	0	8	4
349	R:R:F404	R:R:I165	2.51	No	No	0	8	8
350	R:R:T253	R:R:Y269	2.5	No	Yes	0	7	7
351	R:R:S261	R:R:W264	2.47	No	No	0	7	5
352	R:R:V36	R:R:W39	2.45	No	Yes	0	2	5
353	R:R:D293	R:R:R227	2.38	No	No	0	7	8
354	R:R:Q45	R:R:R48	2.34	No	No	0	5	4
355	R:R:L142	R:R:Y145	2.34	No	Yes	0	3	5
356	R:R:L290	R:R:Y291	2.34	No	Yes	0	3	3
357	R:R:E41	R:R:R44	2.33	No	No	0	4	3
358	R:R:E52	R:R:R48	2.33	No	No	0	2	4
359	R:R:E408	R:R:R176	2.33	No	No	0	9	9
360	R:R:L268	R:R:W264	2.28	No	No	0	2	5
361	R:R:R326	R:R:Y252	2.06	No	No	0	8	8
362	R:R:G275	R:R:P277	2.03	No	Yes	0	6	9
363	R:R:C85	R:R:G98	1.96	No	No	0	9	4
364	R:R:P54	R:R:P55	1.95	No	Yes	7	2	1
365	R:R:P55	R:R:P56	1.95	Yes	No	7	1	1
366	R:R:A106	R:R:G78	1.95	No	No	0	1	7
367	L:L:A28	L:L:G29	1.95	No	No	0	0	0
368	R:R:A239	R:R:P277	1.87	No	Yes	0	8	9
369	R:R:G98	R:R:S84	1.86	No	No	0	4	4
370	R:R:G151	R:R:V150	1.84	No	No	0	8	5
371	R:R:G248	R:R:I323	1.76	No	No	0	8	8
372	R:R:G318	R:R:I317	1.76	No	No	0	4	7
373	R:R:C104	R:R:V81	1.71	No	No	0	9	6
374	R:R:A208	R:R:S206	1.71	No	No	0	4	4
375	R:R:A209	R:R:S206	1.71	No	No	0	1	4
376	R:R:G248	R:R:L251	1.71	No	No	0	8	9
377	R:R:G248	R:R:L360	1.71	No	Yes	0	8	9
378	R:R:L50	R:R:P73	1.64	No	No	0	4	5
379	R:R:C347	R:R:I345	1.64	No	No	0	7	5
380	R:R:S223	R:R:S225	1.63	No	No	0	4	3
381	R:R:S258	R:R:V259	1.62	No	No	0	7	6
382	R:R:S352	R:R:V331	1.62	Yes	No	0	9	8
383	R:R:S301	R:R:T29	1.6	No	No	0	3	2
384	R:R:V281	R:R:V282	1.6	No	No	0	6	3
385	R:R:S352	R:R:T353	1.6	Yes	No	0	9	9
386	R:R:A92	R:R:L89	1.58	No	No	0	5	5
387	R:R:P96	R:R:Q97	1.58	No	No	0	3	4
388	R:R:A316	R:R:L245	1.58	No	No	0	7	8
389	R:R:A368	R:R:L314	1.58	No	No	0	6	4
390	R:R:A375	R:R:L379	1.58	No	No	0	4	3
391	R:R:A185	R:R:N182	1.56	No	No	0	3	9
392	R:R:I272	R:R:S271	1.55	No	No	0	6	3
393	R:R:I161	R:R:V160	1.54	No	No	0	4	3
394	R:R:I196	R:R:V229	1.54	No	No	0	5	7
395	R:R:K334	R:R:S333	1.53	No	No	0	9	7
396	R:R:I146	R:R:T149	1.52	No	No	0	4	7
397	R:R:K336	R:R:V332	1.52	No	No	0	6	6
398	R:R:G377	R:R:R376	1.5	No	No	0	4	5
399	R:R:L245	R:R:V319	1.49	No	No	0	8	6
400	R:R:L401	R:R:V405	1.49	Yes	No	0	8	6
401	R:R:I188	R:R:L192	1.43	No	No	0	7	3
402	R:R:I330	R:R:L255	1.43	No	No	0	9	8
403	R:R:E262	R:R:V259	1.43	No	No	0	6	6
404	R:R:I357	R:R:L354	1.43	No	No	0	8	8
405	R:R:Q47	R:R:T51	1.42	No	No	0	3	4
406	R:R:K415	R:R:L411	1.41	No	No	0	7	4
407	R:R:A153	R:R:F195	1.39	No	No	0	6	7
408	R:R:A191	R:R:F156	1.39	No	No	0	7	7
409	R:R:L166	R:R:L181	1.38	No	No	0	8	6
410	R:R:L228	R:R:L232	1.38	No	No	0	4	5
411	R:R:L278	R:R:L279	1.38	No	No	0	3	4
412	L:L:I27	L:L:Q24	1.37	No	No	0	0	0
413	R:R:D215	R:R:L217	1.36	No	No	0	3	4
414	R:R:L50	R:R:Q47	1.33	No	No	0	4	3
415	R:R:E408	R:R:N407	1.31	No	No	0	9	6
416	R:R:A199	R:R:W203	1.3	No	No	0	3	3
417	L:L:A21	R:R:W214	1.3	No	Yes	0	0	1
418	R:R:S225	R:R:Y220	1.27	No	No	0	3	3
419	R:R:F369	R:R:M371	1.24	No	Yes	0	4	7
420	R:R:Q37	R:R:R40	1.17	No	No	0	4	2
421	R:R:R421	R:R:W420	1	No	No	0	4	4
422	R:R:W417	R:R:W420	0.94	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:W39	8.955	4	1	5
2	R:R:Y42	6.788	5	1	6
3	R:R:P55	4.5775	4	7	1
4	R:R:Y69	5.76667	6	1	6
5	R:R:W72	7.344	5	1	9
6	R:R:Y88	7.645	6	1	5
7	R:R:W91	11.9625	4	0	4
8	R:R:R102	8.438	5	1	8
9	R:R:F103	12.3675	4	9	4
10	R:R:W110	7.88167	6	1	9
11	R:R:R121	6.07	4	1	6
12	R:R:Y145	4.1975	4	0	5
13	R:R:Y152	4.95	5	2	7
14	R:R:L159	4.3575	4	0	9
15	R:R:F187	7.9	4	0	8
16	R:R:R190	6.43667	6	2	8
17	R:R:W214	9.455	6	1	1
18	R:R:Y242	6.192	5	5	6
19	R:R:W243	11.134	5	6	9
20	R:R:Y269	5.27	4	0	7
21	R:R:W274	8.045	6	6	9
22	R:R:P277	4.9875	4	5	9
23	R:R:W284	7.918	5	3	8
24	R:R:Y291	5.3525	4	3	3
25	R:R:E292	6.3	5	3	6
26	R:R:W297	10.416	5	3	8
27	R:R:R299	4.738	5	0	4
28	R:R:Y305	9.0875	4	3	4
29	R:R:W306	6.3125	4	0	6
30	R:R:R310	4.5275	4	11	6
31	R:R:L349	3.62	4	0	9
32	R:R:S352	2.9175	4	0	9
33	R:R:L360	3.185	4	0	9
34	R:R:H363	9.2975	4	2	8
35	R:R:E364	7.666	5	2	8
36	R:R:F367	8.585	4	2	7
37	R:R:M371	4.545	4	11	7
38	R:R:E373	6.1575	4	11	4
39	R:R:F381	4.565	4	0	4
40	R:R:E387	5.595	4	2	8
41	R:R:T391	4.3825	4	2	6
42	R:R:Q394	6.9475	4	2	9
43	R:R:L401	3.1775	4	0	8
44	R:R:Y402	7.18	4	0	8
45	L:L:?2	4.7	4	0	0
46	L:L:E3	5.27333	6	2	0
47	L:L:F6	6.842	5	4	0
48	L:L:Y10	6.7175	4	4	0
49	L:L:L26	5.6575	4	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:D15	L:L:K16	99.2711	6.91	No	No	0	0	0
2	L:L:D15	R:R:R299	100	3.57	No	Yes	0	0	4
3	L:L:K16	L:L:Q19	97.8012	9.49	No	No	0	0	0
4	L:L:Q19	R:R:P90	96.3148	7.9	No	No	0	0	4
5	R:R:P90	R:R:W91	95.5655	10.81	No	Yes	0	4	4
6	R:R:L89	R:R:W91	91.7574	5.69	No	Yes	0	5	4
7	R:R:L89	R:R:Y69	90.1912	9.38	No	Yes	0	5	6
8	R:R:Y69	R:R:Y88	36.0208	3.97	Yes	Yes	1	6	5
9	L:L:L26	R:R:Y88	15.6826	7.03	Yes	Yes	1	0	5
10	L:L:F22	L:L:L26	11.3811	3.65	No	Yes	1	0	0
11	R:R:Y42	R:R:Y88	11.2644	7.94	Yes	Yes	1	6	5
12	R:R:R121	R:R:Y69	50.6388	5.14	Yes	Yes	1	6	6
13	R:R:R102	R:R:R121	49.9857	3.2	Yes	Yes	1	8	6
14	R:R:R102	R:R:W72	45.0025	13.99	Yes	Yes	1	8	9
15	R:R:W110	R:R:W72	42.0727	7.5	Yes	Yes	1	9	9
16	R:R:C62	R:R:W110	20.156	6.53	No	Yes	1	9	9
17	R:R:C62	R:R:G75	19.1405	3.92	No	No	0	9	7
18	R:R:D74	R:R:G75	18.0473	3.35	No	No	0	3	7
19	R:R:D74	R:R:P55	10.2797	11.27	No	Yes	0	3	1
20	R:R:P119	R:R:W110	16.9499	8.11	No	Yes	0	6	9
21	R:R:L118	R:R:P119	15.8484	4.93	No	No	0	4	6
22	R:R:K113	R:R:L118	14.7429	11.28	No	No	0	4	4
23	R:R:K113	R:R:W120	12.5194	4.64	No	No	0	4	5
24	L:L:S11	R:R:R299	90.2445	3.95	No	Yes	0	0	4
25	L:L:S11	R:R:T298	90.7256	6.4	No	No	0	0	5
26	R:R:F230	R:R:T298	91.2374	7.78	No	No	0	5	5
27	R:R:F230	R:R:K197	93.4076	6.2	No	No	0	5	6
28	R:R:K197	R:R:M233	95.0721	12.96	No	No	0	6	6
29	L:L:E3	R:R:M233	69.0034	4.06	Yes	No	0	0	6
30	L:L:E3	R:R:Y152	10.7792	4.49	Yes	Yes	2	0	7
31	R:R:E364	R:R:H363	19.0382	18.46	Yes	Yes	2	8	8
32	R:R:F390	R:R:H363	25.0164	5.66	No	Yes	0	6	8
33	R:R:F390	R:R:S389	22.533	3.96	No	No	0	6	5
34	R:R:F385	R:R:S389	20.0455	5.28	No	No	0	6	5
35	R:R:F385	R:R:L144	17.5538	3.65	No	No	0	6	6
36	R:R:F381	R:R:L144	15.0581	4.87	Yes	No	0	4	6
37	L:L:E3	R:R:R190	59.8293	9.3	Yes	Yes	2	0	8
38	R:R:R190	R:R:T391	10.4967	3.88	Yes	Yes	2	8	6
39	L:L:?2	L:L:E3	28.7691	3.81	Yes	Yes	0	0	0
40	L:L:?2	R:R:E387	17.7811	2.54	Yes	Yes	0	0	8
41	R:R:E364	R:R:E387	17.1792	2.54	Yes	Yes	2	8	8
42	L:L:I12	R:R:R299	17.2345	3.76	No	Yes	0	0	4
43	L:L:?13	L:L:I12	17.0133	5.47	No	No	0	0	0
44	L:L:?13	L:L:L14	17.6849	3.98	No	No	0	0	0
45	L:L:L14	L:L:Y10	21.3107	4.69	No	Yes	0	0	0
46	L:L:F6	L:L:Y10	21.6751	9.28	Yes	Yes	4	0	0
47	L:L:F6	R:R:L388	26.8508	4.87	Yes	No	0	0	7
48	L:L:?2	R:R:L388	27.1067	3.98	Yes	No	0	0	7
49	R:R:H363	R:R:Q394	10.9307	9.89	Yes	Yes	2	8	9
50	R:R:N240	R:R:R190	62.3106	9.64	No	Yes	0	9	8
51	R:R:F187	R:R:N240	27.6718	14.5	Yes	No	0	8	9
52	R:R:F187	R:R:V398	26.4577	3.93	Yes	No	0	8	9
53	R:R:F184	R:R:V398	25.6715	3.93	No	No	0	8	9
54	R:R:C403	R:R:F184	18.3564	4.19	No	No	0	9	8
55	R:R:C403	R:R:L166	16.6858	4.76	No	No	0	9	8
56	R:R:L166	R:R:L172	14.1491	4.15	No	No	0	8	9
57	R:R:L172	R:R:N177	13.2954	12.36	No	No	0	9	9
58	R:R:C174	R:R:N177	12.4376	4.72	No	No	0	8	9
59	R:R:C174	R:R:R176	11.5756	2.79	No	No	0	8	9
60	R:R:E408	R:R:R176	10.7096	2.33	No	No	0	9	9
61	R:R:M233	R:R:S193	30.6936	7.67	No	No	0	6	6
62	R:R:C236	R:R:S193	30.2371	6.89	No	No	0	5	6
63	R:R:C236	R:R:L189	29.0496	4.76	No	No	0	5	7
64	R:R:L189	R:R:W274	28.9862	7.97	No	Yes	0	7	9
65	R:R:W243	R:R:W274	26.081	18.74	Yes	Yes	6	9	9
66	R:R:V246	R:R:W243	75.7534	8.58	No	Yes	0	8	9
67	R:R:V246	R:R:Y269	69.6769	6.31	No	Yes	0	8	7
68	R:R:Y250	R:R:Y269	63.3384	5.96	No	Yes	0	8	7
69	R:R:I179	R:R:Y250	61.7128	8.46	No	No	0	8	8
70	R:R:N240	R:R:S186	59.5631	5.96	No	No	0	9	9
71	R:R:S186	R:R:W243	51.4802	4.94	No	Yes	6	9	9
72	R:R:E247	R:R:I179	55.0467	4.1	No	No	0	9	8
73	R:R:E247	R:R:H180	54.195	9.85	No	No	0	9	9
74	R:R:H180	R:R:Y402	53.3392	7.62	No	Yes	0	9	8
75	L:L:Y1	R:R:V237	16.3459	10.09	No	No	0	0	6
76	L:L:Y1	R:R:Q234	15.6437	13.53	No	No	0	0	7
77	R:R:Q234	R:R:W284	14.9414	5.48	No	Yes	0	7	8
78	R:R:K288	R:R:W284	10.9369	13.92	No	Yes	3	8	8
79	L:L:?2	L:L:T5	18.5673	8.47	Yes	No	0	0	0
80	L:L:T5	R:R:W306	17.6255	4.85	No	Yes	0	0	6
81	R:R:E292	R:R:K288	10.2674	9.45	Yes	No	3	6	8
82	R:R:D372	R:R:W306	11.7988	5.58	No	Yes	0	5	6
83	R:R:D372	R:R:E373	10.7465	7.8	No	Yes	0	5	4
84	R:R:L356	R:R:Y402	11.3996	4.69	No	Yes	0	9	8
85	R:R:L356	R:R:L360	10.4005	2.77	No	Yes	0	9	9
86	R:R:L359	R:R:Y402	11.3996	12.89	No	Yes	0	9	8
87	R:R:L359	R:R:L360	10.4005	2.77	No	Yes	0	9	9
88	R:R:L401	R:R:Y402	32.5588	3.52	Yes	Yes	0	8	8
89	R:R:L401	R:R:P358	29.6843	3.28	Yes	No	0	8	9
90	R:R:I357	R:R:P358	22.8339	5.08	No	No	0	8	9
91	R:R:I357	R:R:T362	20.8398	4.56	No	No	0	8	7
92	R:R:F324	R:R:T362	15.7829	19.46	No	No	0	9	7
93	R:R:F324	R:R:I328	14.7592	3.77	No	No	0	9	7
94	R:R:I328	R:R:T353	13.7315	3.04	No	No	0	7	9
95	R:R:S352	R:R:T353	12.6996	1.6	Yes	No	0	9	9
96	R:R:G248	R:R:L360	16.6714	1.71	No	Yes	0	8	9
97	R:R:G248	R:R:L251	12.5276	1.71	No	No	0	8	9
98	R:R:F187	R:R:Q394	10.4148	5.86	Yes	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:K16	R:R:V30	6.07	0	No	No	0	2	0	1
R:R:R299	R:R:S31	7.91	0	Yes	No	4	4	1	2
R:R:L32	R:R:Q213	6.65	1	No	No	4	4	1	2
R:R:L32	R:R:W214	3.42	1	No	Yes	4	1	1	1
L:L:F22	R:R:L32	3.65	1	No	No	0	4	0	1
L:L:Q19	R:R:T35	7.09	0	No	No	0	5	0	1
R:R:K38	R:R:Y88	3.58	0	No	Yes	4	5	2	1
R:R:R43	R:R:W39	9	0	No	Yes	4	5	2	1
R:R:W39	R:R:Y88	16.4	1	Yes	Yes	5	5	1	1
L:L:L26	R:R:W39	7.97	1	Yes	Yes	0	5	0	1
R:R:P86	R:R:Y42	9.74	1	No	Yes	8	6	2	2
R:R:Y42	R:R:Y88	7.94	1	Yes	Yes	6	5	2	1
L:L:L26	R:R:E68	3.98	1	Yes	No	0	4	0	1
L:L:G29	R:R:E68	4.91	0	No	No	0	4	0	1
R:R:C85	R:R:Y69	5.38	0	No	Yes	9	6	2	1
R:R:Y69	R:R:Y88	3.97	1	Yes	Yes	6	5	1	1
R:R:L89	R:R:Y69	9.38	0	No	Yes	5	6	2	1
R:R:R121	R:R:Y69	5.14	1	Yes	Yes	6	6	1	1
R:R:L123	R:R:Y69	4.69	1	No	Yes	5	6	2	1
L:L:I27	R:R:Y69	6.04	1	No	Yes	0	6	0	1
R:R:P86	R:R:Y88	6.95	1	No	Yes	8	5	2	1
L:L:L26	R:R:Y88	7.03	1	Yes	Yes	0	5	0	1
R:R:L89	R:R:W91	5.69	0	No	Yes	5	4	2	1
R:R:P90	R:R:W91	10.81	0	No	Yes	4	4	1	1
L:L:Q19	R:R:P90	7.9	0	No	No	0	4	0	1
R:R:E128	R:R:W91	23.99	0	No	Yes	3	4	1	1
L:L:V23	R:R:W91	7.36	0	No	Yes	0	4	0	1
R:R:R102	R:R:R121	3.2	1	Yes	Yes	8	6	2	1
R:R:L123	R:R:R121	10.93	1	No	Yes	5	6	2	1
L:L:I27	R:R:R121	5.01	1	No	Yes	0	6	0	1
R:R:E127	R:R:E128	15.22	0	No	No	2	3	2	1
L:L:K20	R:R:E128	4.05	0	No	No	0	3	0	1
L:L:F6	R:R:L141	3.65	4	Yes	No	0	5	0	1
L:L:Y10	R:R:L141	9.38	4	Yes	No	0	5	0	1
R:R:Y145	R:R:Y148	3.97	0	Yes	No	5	7	2	1
L:L:F6	R:R:Y148	10.32	4	Yes	No	0	7	0	1
R:R:R190	R:R:Y152	5.14	2	Yes	Yes	8	7	1	1
R:R:V194	R:R:Y152	8.83	2	No	Yes	7	7	1	1
R:R:T391	R:R:Y152	3.75	2	Yes	Yes	6	7	2	1
L:L:E3	R:R:Y152	4.49	2	Yes	Yes	0	7	0	1
R:R:R190	R:R:V237	6.54	2	Yes	No	8	6	1	1
R:R:N240	R:R:R190	9.64	0	No	Yes	9	8	2	1
R:R:R190	R:R:Y241	4.12	2	Yes	No	8	8	1	2
R:R:R190	R:R:T391	3.88	2	Yes	Yes	8	6	1	2
L:L:E3	R:R:R190	9.3	2	Yes	Yes	0	8	0	1
R:R:M233	R:R:S193	7.67	0	No	No	6	6	1	2
L:L:E3	R:R:V194	4.28	2	Yes	No	0	7	0	1
R:R:F230	R:R:K197	6.2	0	No	No	5	6	2	1
R:R:K197	R:R:M233	12.96	0	No	No	6	6	1	1
L:L:T7	R:R:K197	6.01	0	No	No	0	6	0	1
L:L:Y10	R:R:L201	3.52	4	Yes	No	0	7	0	1
R:R:M204	R:R:Y205	13.17	0	No	No	3	3	2	1
L:L:L14	R:R:Y205	5.86	0	No	No	0	3	0	1
R:R:Q210	R:R:W214	12.05	0	No	Yes	4	1	1	1
L:L:A18	R:R:Q210	4.55	0	No	No	0	4	0	1
R:R:Q211	R:R:W214	9.86	1	No	Yes	4	1	1	1
L:L:W25	R:R:Q211	3.29	1	No	No	0	4	0	1
L:L:F22	R:R:W214	16.04	1	No	Yes	0	1	0	1
L:L:W25	R:R:W214	14.06	1	No	Yes	0	1	0	1
R:R:F230	R:R:T298	7.78	0	No	No	5	5	2	1
L:L:E3	R:R:M233	4.06	2	Yes	No	0	6	0	1
R:R:Q234	R:R:W284	5.48	0	No	Yes	7	8	1	2
L:L:Y1	R:R:Q234	13.53	0	No	No	0	7	0	1
L:L:Y1	R:R:V237	10.09	0	No	No	0	6	0	1
L:L:E3	R:R:V237	5.7	2	Yes	No	0	6	0	1
R:R:E364	R:R:Y241	6.73	2	Yes	No	8	8	2	2
R:R:I309	R:R:W284	11.74	0	No	Yes	7	8	2	2
R:R:G295	R:R:R299	4.5	0	No	Yes	4	4	2	1
L:L:S11	R:R:T298	6.4	0	No	No	0	5	0	1
L:L:S11	R:R:R299	3.95	0	No	Yes	0	4	0	1
L:L:I12	R:R:R299	3.76	0	No	Yes	0	4	0	1
L:L:D15	R:R:R299	3.57	0	No	Yes	0	4	0	1
R:R:N300	R:R:W306	11.3	0	No	Yes	6	6	1	1
L:L:S8	R:R:N300	4.47	0	No	No	0	6	0	1
R:R:I309	R:R:W306	3.52	0	No	Yes	7	6	2	1
R:R:D372	R:R:W306	5.58	0	No	Yes	5	6	2	1
L:L:T5	R:R:W306	4.85	0	No	Yes	0	6	0	1
R:R:E364	R:R:T391	4.23	2	Yes	Yes	8	6	2	2
R:R:F367	R:R:T386	6.49	2	Yes	No	7	4	2	2
R:R:E387	R:R:F367	11.66	2	Yes	Yes	8	7	1	2
R:R:L384	R:R:R380	3.64	4	No	No	5	5	1	1
L:L:D9	R:R:R380	4.76	4	No	No	0	5	0	1
L:L:F6	R:R:L384	6.09	4	Yes	No	0	5	0	1
L:L:D9	R:R:L384	5.43	4	No	No	0	5	0	1
R:R:E387	R:R:T386	5.64	2	Yes	No	8	4	1	2
L:L:?2	R:R:L388	3.98	0	Yes	No	0	7	0	1
L:L:F6	R:R:L388	4.87	4	Yes	No	0	7	0	1
R:R:Q210	R:R:T207	2.83	0	No	No	4	3	1	2
R:R:A375	R:R:R380	2.77	0	No	No	4	5	2	1
R:R:S392	R:R:Y152	2.54	0	No	Yes	9	7	2	1
R:R:E364	R:R:E387	2.54	2	Yes	Yes	8	8	2	1
L:L:?2	R:R:E387	2.54	0	Yes	Yes	0	8	0	1
R:R:V36	R:R:W39	2.45	0	No	Yes	2	5	2	1
L:L:A21	R:R:W214	1.3	0	No	Yes	0	1	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7FIM_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.2
Number of Linked Nodes	392
Number of Links	422
Number of Hubs	49
Number of Links mediated by Hubs	186
Number of Communities	11
Number of Nodes involved in Communities	70
Number of Links involved in Communities	89

Path Summary
Number Of Nodes in MetaPath	99
Number Of Links MetaPath	98
Number of Shortest Paths	101557
Length Of Smallest Path	3
Average Path Length	20.6703
Length of Longest Path	50
Minimum Path Strength	0.97
Average Path Strength	6.65056
Maximum Path Strength	20.785
Minimum Path Correlation	0.7
Average Path Correlation	0.963153
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.94118
Average % Of Corr. Nodes	58.7708
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.0034
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• peptide hormone receptor binding • protein binding • binding • corticotropin-releasing hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • molecular function regulator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • insulin-like growth factor receptor binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • intracellular anatomical structure • cytoplasm • glucagon receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • amide binding • binding • peptide hormone binding • hormone binding • glucagon-like peptide 1 receptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • heart process • multicellular organismal process • system process • regulation of biological process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • regulation of blood pressure • positive regulation of blood pressure • cellular response to stimulus • regulation of cellular process • response to stimulus • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to stress • response to psychosocial stress • cell surface receptor signaling pathway • behavior • learning or memory • nervous system process • cognition • transport • secretion • regulation of hormone levels • cell-cell signaling • export from cell • hormone secretion • establishment of localization • localization • secretion by cell • signal release • hormone transport • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • establishment of protein localization • cellular localization • nitrogen compound transport • protein targeting • protein transmembrane transport • establishment of localization in cell • post-translational protein targeting to membrane, translocation • intracellular protein localization • establishment of protein localization to endoplasmic reticulum • establishment of protein localization to membrane • intracellular protein transmembrane transport • intracellular transport • post-translational protein targeting to endoplasmic reticulum membrane • localization within membrane • protein targeting to membrane • transmembrane transport • establishment of protein localization to organelle • protein transport • macromolecule localization • intracellular protein transport • protein targeting to ER • negative regulation of blood pressure • protein binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • G protein-coupled receptor-like • FnI-like domain • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • G protein-coupled receptor-like • FnI-like domain • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	AIB
PDB Residues	L:L:?2 L:L:?13
Environment Details	Open EMBL-EBI Page
Code	AIB
Name	2-aminoisobutyric acid
Synonyms	α-aminoisobutyric acid
Identifier
Formula	C4 H9 N O2
Molecular Weight	103.12
SMILES
PubChem	5245672
Formal Charge	0
Total Atoms	16
Total Chiral Atoms	0
Total Bonds	15
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43220
Sequence	>7FIM_nogp_Chain_R A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F R H L H C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S T A A Q Q H Q W D G L L S Y Q D S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S V L S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E D E G C W T R N S N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A D I K C R L A K S T L T L I P L L G T H E V I F A F V M D E H A R G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E V Q L E F R K S W E R W R L E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	doi.org/10.1038/nature22378
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.2	2020-03-18	doi.org/10.1038/s41467-020-14934-5
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.1	2019-11-13	doi.org/10.1107/S2052252519013496
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	doi.org/10.1038/nature22378
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	doi.org/10.1021/acs.jmedchem.1c01856
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	doi.org/10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	doi.org/10.1038/nature22394
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	doi.org/10.1038/nature22800
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	doi.org/10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	doi.org/10.1038/nature25773
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-	Gs/β1/γ2	3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-		3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-		2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	9EBN	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBN (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-	Gs/β1/γ2	3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-		3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	8YWF	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	2.74	2025-04-16	To be published
	8YWF (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.74	2025-04-16	To be published
	9BYO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-	Gs/β1/γ2	2.31	2025-06-11	To be published
	9BYO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-		2.31	2025-06-11	To be published
	9C0K	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	2.72	2025-06-11	To be published
	9C0K (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		2.72	2025-06-11	To be published

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Download 7FIM_nogp.zip

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