CodeAIB
Name2-aminoisobutyric acid
Synonymsα-methylalanine
Identifier2-amino-2-methyl-propanoic acid
FormulaC4 H9 N O2
Molecular Weight103.12
SMILESCC(C)(C(=O)O)N
PubChem6119
Formal Charge0
Total Atoms16
Total Chiral Atoms0
Total Bonds15
Total Aromatic Bonds0
Networks16
 missing image

This ligand is also present in the following 16 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6FJ3 B1 Peptide Parathyroid hormone PTH1 Homo sapiens PTH - - 2.5 2018-11-21 10.1038/s41594-018-0151-4

A 2D representation of the interactions of AIB in 6FJ3
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L187 R:R:M441 4.24 0 No No 5 6 2 1
R:R:R233 R:R:Y195 8.23 1 Yes Yes 8 7 2 2
L:L:E4 R:R:Y195 5.61 1 Yes Yes 0 7 1 2
R:R:F288 R:R:R233 6.41 1 Yes Yes 7 8 2 2
R:R:L292 R:R:R233 3.64 1 No Yes 6 8 2 2
R:R:N448 R:R:R233 3.62 1 Yes Yes 6 8 2 2
L:L:V2 R:R:R233 3.92 1 Yes Yes 0 8 1 2
L:L:E4 R:R:R233 5.82 1 Yes Yes 0 8 1 2
L:L:E4 R:R:F288 5.83 1 Yes Yes 0 7 1 2
L:L:V2 R:R:L292 4.47 1 Yes No 0 6 1 2
R:R:F424 R:R:R440 4.28 1 Yes Yes 7 6 2 2
R:R:E444 R:R:F424 31.48 1 Yes Yes 7 7 1 2
R:R:M441 R:R:W437 17.45 0 No No 6 5 1 2
R:R:E444 R:R:R440 11.63 1 Yes Yes 7 6 1 2
L:L:?3 R:R:M441 4.06 1 Yes No 0 6 0 1
R:R:E444 R:R:N448 6.57 1 Yes Yes 7 6 1 2
L:L:?3 R:R:E444 20.31 1 Yes Yes 0 7 0 1
L:L:?3 R:R:M445 6.77 1 Yes No 0 6 0 1
L:L:E4 R:R:M445 4.06 1 Yes No 0 6 1 1
L:L:E4 R:R:N448 11.83 1 Yes Yes 0 6 1 2
L:L:?1 L:L:V2 8.76 0 Yes Yes 0 0 2 1
L:L:?3 L:L:V2 4.28 1 Yes Yes 0 0 0 1
L:L:E4 L:L:V2 9.98 1 Yes Yes 0 0 1 1
L:L:?3 L:L:E4 11.42 1 Yes Yes 0 0 0 1
R:R:C191 R:R:M445 3.24 0 No No 7 6 2 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.37
Average Nodes In Shell17.00
Average Hubs In Shell11.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell22.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7FIM B1 Peptide Glucagon GLP-1 Homo sapiens Tirzepatide - Gs/Beta1/Gamma2 3.4 2022-03-02 10.1038/s41467-022-28683-0

A 2D representation of the interactions of AIB in 7FIM
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:R190 R:R:Y152 5.14 1 Yes Yes 8 7 2 2
R:R:V194 R:R:Y152 8.83 1 No Yes 7 7 2 2
L:L:E3 R:R:Y152 4.49 1 Yes Yes 0 7 1 2
R:R:R190 R:R:V237 6.54 1 Yes No 8 6 2 2
L:L:E3 R:R:R190 9.3 1 Yes Yes 0 8 1 2
R:R:M233 R:R:V194 3.04 1 Yes No 6 7 2 2
L:L:E3 R:R:V194 4.28 1 Yes No 0 7 1 2
L:L:E3 R:R:M233 4.06 1 Yes Yes 0 6 1 2
L:L:E3 R:R:V237 5.7 1 Yes No 0 6 1 2
L:L:T5 R:R:W306 4.85 0 No Yes 0 6 1 2
R:R:F367 R:R:T386 6.49 1 Yes No 7 4 2 2
R:R:E387 R:R:F367 11.66 1 Yes Yes 8 7 1 2
R:R:E387 R:R:T386 5.64 1 Yes No 8 4 1 2
L:L:?2 R:R:L388 3.98 0 Yes No 0 7 0 1
L:L:F6 R:R:L388 4.87 16 Yes No 0 7 2 1
L:L:?2 L:L:E3 3.81 0 Yes Yes 0 0 0 1
L:L:?2 L:L:T5 8.47 0 Yes No 0 0 0 1
R:R:E364 R:R:E387 2.54 1 Yes Yes 8 8 2 1
L:L:?2 R:R:E387 2.54 0 Yes Yes 0 8 0 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub2.00
Average Interaction Strength4.70
Average Nodes In Shell15.00
Average Hubs In Shell10.00
Average Links In Shell19.00
Average Links Mediated by Hubs In Shell19.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of AIB in 7FIM
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:L14 R:R:Y205 5.86 0 No No 0 3 1 2
L:L:I12 R:R:R299 3.76 0 No Yes 0 4 1 2
L:L:L14 L:L:Y10 4.69 0 No Yes 0 0 1 2
L:L:?13 L:L:I12 5.47 0 No No 0 0 0 1
L:L:?13 L:L:L14 3.98 0 No No 0 0 0 1
L:L:?13 L:L:I17 5.47 0 No No 0 0 0 1
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub0.00
Average Interaction Strength4.97
Average Nodes In Shell7.00
Average Hubs In Shell2.00
Average Links In Shell6.00
Average Links Mediated by Hubs In Shell2.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7FIN B1 Peptide Glucagon GIP Homo sapiens Peptide-20; GGL - Gs/Beta1/Gamma2 3.1 2022-02-23 10.1038/s41467-022-28683-0

A 2D representation of the interactions of AIB in 7FIN
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:Y141 R:R:Y145 5.96 5 Yes Yes 7 7 2 2
L:L:Q3 R:R:Y141 4.51 5 Yes Yes 0 7 1 2
R:R:I187 R:R:Y145 7.25 5 No Yes 7 7 2 2
L:L:Q3 R:R:Y145 10.15 5 Yes Yes 0 7 1 2
R:R:I187 R:R:R183 5.01 5 No Yes 7 8 2 2
R:R:R183 R:R:V227 6.54 5 Yes No 8 6 2 2
L:L:H1 R:R:R183 5.64 5 Yes Yes 0 8 1 2
L:L:Q3 R:R:I187 9.61 5 Yes No 0 7 1 2
L:L:H1 R:R:V227 13.84 5 Yes No 0 6 1 2
L:L:G4 R:R:W296 2.81 5 No Yes 0 6 1 2
L:L:T5 R:R:W296 3.64 0 No Yes 0 6 1 2
R:R:F357 R:R:K373 4.96 5 No Yes 7 7 2 2
R:R:E377 R:R:F357 32.65 5 No No 7 7 1 2
R:R:E377 R:R:K373 2.7 5 No Yes 7 7 1 2
L:L:?2 R:R:E377 7.62 5 Yes No 0 7 0 1
L:L:?2 L:L:H1 4.93 5 Yes Yes 0 0 0 1
L:L:H1 L:L:Q3 3.71 5 Yes Yes 0 0 1 1
L:L:G4 L:L:H1 3.18 5 No Yes 0 0 1 1
L:L:?2 L:L:Q3 2.55 5 Yes Yes 0 0 0 1
L:L:?2 L:L:G4 3.28 5 Yes No 0 0 0 1
L:L:?2 L:L:T5 7.06 5 Yes No 0 0 0 1
L:L:D9 L:L:T5 2.89 0 No No 0 0 2 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub2.00
Average Interaction Strength5.09
Average Nodes In Shell15.00
Average Hubs In Shell8.00
Average Links In Shell22.00
Average Links Mediated by Hubs In Shell20.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7FIY B1 Peptide Glucagon GIP Homo sapiens Tirzepatide - Gs/Beta1/Gamma2 3.4 2022-03-02 10.1038/s41467-022-28683-0

A 2D representation of the interactions of AIB in 7FIY
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:E3 R:R:Y145 3.37 4 Yes Yes 0 7 1 2
R:R:R183 R:R:V227 5.23 4 Yes No 8 6 2 2
R:R:R183 R:R:S381 5.27 4 Yes No 8 5 2 2
L:L:Y1 R:R:R183 3.09 4 Yes Yes 0 8 1 2
L:L:E3 R:R:R183 9.3 4 Yes Yes 0 8 1 2
L:L:Y1 R:R:Q224 5.64 4 Yes Yes 0 6 1 2
L:L:Y1 R:R:V227 16.4 4 Yes No 0 6 1 2
R:R:R300 R:R:W296 13 21 Yes Yes 7 6 2 2
L:L:Y1 R:R:W296 2.89 4 Yes Yes 0 6 1 2
L:L:T5 R:R:R300 5.17 0 No Yes 0 7 1 2
L:L:E3 R:R:S381 7.19 4 Yes No 0 5 1 2
L:L:?2 L:L:Y1 3.37 4 Yes Yes 0 0 0 1
L:L:E3 L:L:Y1 7.86 4 Yes Yes 0 0 1 1
L:L:G4 L:L:Y1 5.79 4 No Yes 0 0 1 1
L:L:?2 L:L:E3 12.69 4 Yes Yes 0 0 0 1
L:L:?2 L:L:G4 3.28 4 Yes No 0 0 0 1
L:L:?2 L:L:T5 8.47 4 Yes No 0 0 0 1
L:L:G4 L:L:T7 3.64 4 No No 0 0 1 2
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub2.00
Average Interaction Strength6.95
Average Nodes In Shell13.00
Average Hubs In Shell8.00
Average Links In Shell18.00
Average Links Mediated by Hubs In Shell17.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of AIB in 7FIY
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P197 R:R:R196 2.88 14 Yes No 4 3 2 2
L:L:Y10 R:R:R196 3.09 14 No No 0 3 2 2
L:L:L14 R:R:R196 8.5 14 Yes No 0 3 1 2
L:L:L14 R:R:P197 3.28 14 Yes Yes 0 4 1 2
L:L:L14 L:L:Y10 4.69 14 Yes No 0 0 1 2
L:L:?13 L:L:I12 5.47 0 Yes No 0 0 0 1
L:L:?13 L:L:K16 5.4 0 Yes No 0 0 0 1
L:L:?13 L:L:I17 5.47 0 Yes No 0 0 0 1
L:L:?13 L:L:L14 2.65 0 Yes Yes 0 0 0 1
L:L:I17 R:R:R131 2.51 0 No No 0 3 1 2
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub1.00
Average Interaction Strength4.75
Average Nodes In Shell9.00
Average Hubs In Shell3.00
Average Links In Shell10.00
Average Links Mediated by Hubs In Shell8.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7KI0 B1 Peptide Glucagon GLP-1 Homo sapiens Semaglutide - Gs/Beta1/Gamma2 2.5 2021-08-04 10.1016/j.celrep.2021.109374

A 2D representation of the interactions of AIB in 7KI0
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L144 R:R:L388 4.15 2 Yes Yes 6 7 2 1
L:L:F12 R:R:L144 6.09 2 Yes Yes 0 6 2 2
R:R:L388 R:R:Y148 3.52 2 Yes Yes 7 7 1 2
L:L:F12 R:R:Y148 8.25 2 Yes Yes 0 7 2 2
R:R:R190 R:R:Y152 8.23 2 Yes Yes 8 7 2 2
L:L:E9 R:R:Y152 6.73 2 Yes Yes 0 7 1 2
R:R:R190 R:R:V237 6.54 2 Yes No 8 6 2 2
L:L:E9 R:R:R190 11.63 2 Yes Yes 0 8 1 2
L:L:H7 R:R:Q234 8.65 2 Yes No 0 7 1 2
L:L:H7 R:R:V237 15.22 2 Yes No 0 6 1 2
L:L:H7 R:R:W306 8.46 2 Yes Yes 0 6 1 2
L:L:H7 R:R:I313 3.98 2 Yes No 0 7 1 2
R:R:E387 R:R:F367 3.5 0 No Yes 8 7 1 2
L:L:T11 R:R:D372 8.67 0 No Yes 0 5 1 2
R:R:E387 R:R:K383 13.5 0 No No 8 7 1 2
L:L:?8 R:R:E387 8.88 2 Yes No 0 8 0 1
L:L:?8 R:R:L388 3.98 2 Yes Yes 0 7 0 1
L:L:E9 R:R:L388 3.98 2 Yes Yes 0 7 1 1
L:L:F12 R:R:L388 3.65 2 Yes Yes 0 7 2 1
L:L:E9 R:R:T391 4.23 2 Yes No 0 6 1 2
L:L:?8 L:L:H7 4.93 2 Yes Yes 0 0 0 1
L:L:E9 L:L:H7 3.69 2 Yes Yes 0 0 1 1
L:L:G10 L:L:H7 4.77 0 No Yes 0 0 2 1
L:L:?8 L:L:E9 11.42 2 Yes Yes 0 0 0 1
L:L:?8 L:L:T11 9.88 2 Yes No 0 0 0 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.82
Average Nodes In Shell20.00
Average Hubs In Shell12.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell24.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7KI1 B1 Peptide Glucagon GLP-1 Homo sapiens Taspoglutide - Gs/Beta1/Gamma2 2.5 2021-08-04 10.1016/j.celrep.2021.109374

A 2D representation of the interactions of AIB in 7KI1
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:Q234 R:R:W306 7.67 2 No Yes 7 6 2 2
L:L:H7 R:R:Q234 6.18 2 Yes No 0 7 1 2
L:L:H7 R:R:V237 15.22 2 Yes No 0 6 1 2
R:R:I313 R:R:Y241 10.88 2 No Yes 7 8 2 2
L:L:H7 R:R:Y241 3.27 2 Yes Yes 0 8 1 2
L:L:H7 R:R:W306 7.41 2 Yes Yes 0 6 1 2
L:L:H7 R:R:I313 3.98 2 Yes No 0 7 1 2
L:L:T11 R:R:D372 7.23 2 No No 0 5 1 2
R:R:E387 R:R:K383 4.05 0 No No 8 7 1 2
L:L:?8 R:R:L384 6.63 2 Yes No 0 5 0 1
L:L:T11 R:R:L384 5.9 2 No No 0 5 1 1
L:L:?8 R:R:E387 12.69 2 Yes No 0 8 0 1
L:L:?8 L:L:H7 4.93 2 Yes Yes 0 0 0 1
L:L:G10 L:L:H7 3.18 0 No Yes 0 0 2 1
L:L:?8 L:L:T11 11.29 2 Yes No 0 0 0 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub1.00
Average Interaction Strength8.88
Average Nodes In Shell13.00
Average Hubs In Shell4.00
Average Links In Shell15.00
Average Links Mediated by Hubs In Shell12.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of AIB in 7KI1
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?35 R:R:E68 3.81 5 No No 0 4 0 1
L:L:R36 R:R:E68 5.82 5 No No 0 4 1 1
L:L:W31 R:R:H212 7.41 5 Yes Yes 0 3 2 2
L:L:K34 R:R:H212 3.93 5 No Yes 0 3 1 2
L:L:K34 L:L:W31 4.64 5 No Yes 0 0 1 2
L:L:?35 L:L:K34 5.4 5 No No 0 0 0 1
L:L:?35 L:L:R36 5.82 5 No No 0 0 0 1
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub0.00
Average Interaction Strength5.01
Average Nodes In Shell6.00
Average Hubs In Shell2.00
Average Links In Shell7.00
Average Links Mediated by Hubs In Shell3.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7RBT B1 Peptide Glucagon GIP Homo sapiens Tirzepatide PubChem 163183774 chim(NtGi1-Gs)/Beta1/Gamma2 3.08 2022-04-13 10.1073/pnas.2116506119

A 2D representation of the interactions of AIB in 7RBT
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 L:L:Y1 11.23 2 Yes Yes 0 0 0 1
L:L:E3 L:L:Y1 3.37 2 Yes Yes 0 0 1 1
L:L:G4 L:L:Y1 5.79 2 No Yes 0 0 1 1
L:L:Y1 R:R:R183 2.06 2 Yes Yes 0 8 1 2
L:L:Y1 R:R:I187 2.42 2 Yes Yes 0 7 1 2
L:L:Y1 R:R:V227 16.4 2 Yes Yes 0 6 1 2
L:L:Y1 R:R:Y231 3.97 2 Yes Yes 0 8 1 2
L:L:Y1 R:R:W296 4.82 2 Yes Yes 0 6 1 2
L:L:?2 L:L:E3 12.69 2 Yes Yes 0 0 0 1
L:L:?2 L:L:G4 3.28 2 Yes No 0 0 0 1
L:L:?2 L:L:T5 2.82 2 Yes No 0 0 0 1
L:L:?2 R:R:E377 3.81 2 Yes No 0 7 0 1
L:L:?2 R:R:I378 6.84 2 Yes Yes 0 8 0 1
L:L:?2 R:R:S381 2.88 2 Yes No 0 5 0 1
L:L:E3 R:R:Y145 8.98 2 Yes Yes 0 7 1 2
L:L:E3 R:R:R183 4.65 2 Yes Yes 0 8 1 2
L:L:E3 R:R:I187 8.2 2 Yes Yes 0 7 1 2
L:L:E3 R:R:I378 4.1 2 Yes Yes 0 8 1 1
L:L:E3 R:R:S381 8.62 2 Yes No 0 5 1 1
L:L:D9 L:L:T5 4.34 0 No No 0 0 2 1
L:L:F6 R:R:Y141 14.44 2 Yes Yes 0 7 2 2
L:L:F6 R:R:I378 2.51 2 Yes Yes 0 8 2 1
R:R:I378 R:R:M140 4.37 2 Yes No 8 6 1 2
R:R:Y141 R:R:Y145 5.96 2 Yes Yes 7 7 2 2
R:R:I378 R:R:Y141 3.63 2 Yes Yes 8 7 1 2
R:R:R183 R:R:Y145 3.09 2 Yes Yes 8 7 2 2
R:R:I187 R:R:R183 2.51 2 Yes Yes 7 8 2 2
R:R:R183 R:R:V227 9.15 2 Yes Yes 8 6 2 2
R:R:R183 R:R:Y231 6.17 2 Yes Yes 8 8 2 2
R:R:R183 R:R:S381 3.95 2 Yes No 8 5 2 1
R:R:I187 R:R:V227 3.07 2 Yes Yes 7 6 2 2
R:R:V227 R:R:Y231 2.52 2 Yes Yes 6 8 2 2
R:R:E377 R:R:F357 15.16 0 No Yes 7 7 1 2
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub3.00
Average Interaction Strength6.22
Average Nodes In Shell19.00
Average Hubs In Shell13.00
Average Links In Shell33.00
Average Links Mediated by Hubs In Shell32.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of AIB in 7RBT
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:L14 L:L:Y10 8.21 0 Yes Yes 0 0 1 2
L:L:?13 L:L:I12 6.84 7 Yes No 0 0 0 1
L:L:I12 L:L:K16 4.36 7 No No 0 0 1 1
L:L:I12 R:R:R289 8.77 7 No Yes 0 4 1 2
L:L:?13 L:L:L14 3.98 7 Yes Yes 0 0 0 1
L:L:?13 L:L:K16 2.7 7 Yes No 0 0 0 1
L:L:?13 L:L:I17 4.1 7 Yes Yes 0 0 0 1
L:L:?13 R:R:F127 2.33 7 Yes No 0 2 0 1
L:L:L14 R:R:R131 2.43 0 Yes Yes 0 3 1 2
L:L:L14 R:R:P197 1.64 0 Yes No 0 4 1 2
L:L:D15 L:L:K16 4.15 0 Yes No 0 0 2 1
L:L:D15 R:R:R289 4.76 0 Yes Yes 0 4 2 2
L:L:I17 L:L:K20 2.91 7 Yes No 0 0 1 2
L:L:I17 R:R:L128 2.85 7 Yes No 0 3 1 2
L:L:I17 R:R:R131 3.76 7 Yes Yes 0 3 1 2
L:L:K20 R:R:L128 5.64 7 No No 0 3 2 2
R:R:E125 R:R:F127 8.16 0 No No 3 2 2 1
R:R:L128 R:R:R131 2.43 7 No Yes 3 3 2 2
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub2.00
Average Interaction Strength3.99
Average Nodes In Shell14.00
Average Hubs In Shell7.00
Average Links In Shell18.00
Average Links Mediated by Hubs In Shell15.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7RGP B1 Peptide Glucagon GLP-1 Homo sapiens Tirzepatide - chim(NtGi1-Gs)/Beta1/Gamma2 2.9 2022-04-13 10.1073/pnas.2116506119

A 2D representation of the interactions of AIB in 7RGP
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 L:L:Y1 8.98 2 Yes Yes 0 0 0 1
L:L:G4 L:L:Y1 4.35 2 Yes Yes 0 0 1 1
L:L:Y1 R:R:Q234 7.89 2 Yes Yes 0 7 1 2
L:L:Y1 R:R:V237 5.05 2 Yes No 0 6 1 2
L:L:Y1 R:R:W306 9.65 2 Yes Yes 0 6 1 2
L:L:Y1 R:R:I309 3.63 2 Yes Yes 0 7 1 2
L:L:?2 L:L:E3 6.35 2 Yes Yes 0 0 0 1
L:L:?2 L:L:G4 3.28 2 Yes Yes 0 0 0 1
L:L:?2 L:L:T5 4.24 2 Yes No 0 0 0 1
L:L:E3 R:R:Y148 12.35 2 Yes Yes 0 7 1 2
L:L:E3 R:R:Y152 7.86 2 Yes Yes 0 7 1 2
L:L:E3 R:R:R190 15.12 2 Yes Yes 0 8 1 2
L:L:E3 R:R:V194 4.28 2 Yes No 0 7 1 2
L:L:G4 L:L:T7 3.64 2 Yes No 0 0 1 2
L:L:G4 R:R:W306 2.81 2 Yes Yes 0 6 1 2
L:L:T5 R:R:D372 4.34 0 No Yes 0 5 1 2
L:L:T5 R:R:L384 7.37 0 No No 0 5 1 2
R:R:Y148 R:R:Y152 14.89 2 Yes Yes 7 7 2 2
R:R:V194 R:R:Y148 7.57 2 No Yes 7 7 2 2
R:R:R190 R:R:Y152 6.17 2 Yes Yes 8 7 2 2
R:R:V194 R:R:Y152 6.31 2 No Yes 7 7 2 2
R:R:R190 R:R:V237 3.92 2 Yes No 8 6 2 2
R:R:Q234 R:R:W306 9.86 2 Yes Yes 7 6 2 2
R:R:I309 R:R:Q234 6.86 2 Yes Yes 7 7 2 2
R:R:I309 R:R:W306 7.05 2 Yes Yes 7 6 2 2
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub3.00
Average Interaction Strength5.71
Average Nodes In Shell16.00
Average Hubs In Shell11.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell24.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of AIB in 7RGP
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:L14 L:L:Y10 11.72 0 No Yes 0 0 1 2
L:L:?13 L:L:I12 5.47 0 Yes No 0 0 0 1
L:L:?13 L:L:L14 6.63 0 Yes No 0 0 0 1
L:L:?13 L:L:K16 4.05 0 Yes No 0 0 0 1
L:L:?13 L:L:I17 4.1 0 Yes No 0 0 0 1
L:L:L14 R:R:Y205 3.52 0 No No 0 3 1 2
L:L:K16 L:L:K20 5.75 0 No No 0 0 1 2
L:L:I17 L:L:K20 2.91 0 No No 0 0 1 2
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub0.00
Average Interaction Strength5.06
Average Nodes In Shell8.00
Average Hubs In Shell2.00
Average Links In Shell8.00
Average Links Mediated by Hubs In Shell5.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7RTB B1 Peptide Glucagon GLP-1 Homo sapiens Peptide-19 - Gs/Beta1/Gamma2 2.14 2021-10-06 10.1016/j.bbrc.2021.09.016

A 2D representation of the interactions of AIB in 7RTB
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L314 R:R:R310 7.29 37 No Yes 4 6 2 2
L:L:Y1 R:R:R310 12.35 37 Yes Yes 0 6 1 2
L:L:Y1 R:R:I313 3.63 37 Yes No 0 7 1 2
L:L:Y1 R:R:L314 8.21 37 Yes No 0 4 1 2
L:L:?2 L:L:Y1 8.98 0 No Yes 0 0 0 1
L:L:?2 L:L:G4 3.28 0 No No 0 0 0 1
L:L:?2 L:L:T5 12.71 0 No No 0 0 0 1
L:L:E3 L:L:G4 4.91 2 Yes No 0 0 2 1
L:L:E3 L:L:T7 4.23 2 Yes No 0 0 2 2
L:L:G4 L:L:T7 3.64 2 No No 0 0 1 2
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub1.00
Average Interaction Strength8.32
Average Nodes In Shell9.00
Average Hubs In Shell3.00
Average Links In Shell10.00
Average Links Mediated by Hubs In Shell7.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of AIB in 7RTB
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?20 L:L:Q17 3.82 39 Yes No 0 0 0 1
L:L:E21 L:L:Q17 16.57 39 No No 0 0 1 1
L:L:?20 L:L:E21 10.15 39 Yes No 0 0 0 1
L:L:?20 L:L:V23 4.28 39 Yes No 0 0 0 1
L:L:E21 R:R:A209 3.02 39 No No 0 1 1 2
L:L:V23 R:R:L89 2.98 0 No Yes 0 5 1 2
L:L:?20 L:L:N24 2.63 39 Yes No 0 0 0 1
L:L:G29 L:L:N24 1.7 0 No No 0 0 2 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub0.00
Average Interaction Strength5.22
Average Nodes In Shell8.00
Average Hubs In Shell2.00
Average Links In Shell8.00
Average Links Mediated by Hubs In Shell5.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7V35 B1 Peptide Glucagon Glucagon Homo sapiens Peptide-20 - Gs/Beta1/Gamma2 3.5 2022-03-02 10.1038/s41467-022-28683-0

A 2D representation of the interactions of AIB in 7V35
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 L:L:H1 7.39 2 Yes Yes 0 0 0 1
L:L:H1 L:L:Q3 2.47 2 Yes Yes 0 0 1 1
L:L:G4 L:L:H1 4.77 2 No Yes 0 0 2 1
L:L:H1 R:R:Q232 6.18 2 Yes Yes 0 7 1 2
L:L:H1 R:R:I235 11.93 2 Yes No 0 5 1 2
L:L:H1 R:R:W304 3.17 2 Yes Yes 0 6 1 2
L:L:?2 L:L:Q3 2.55 2 Yes Yes 0 0 0 1
L:L:?2 L:L:T5 4.24 2 Yes Yes 0 0 0 1
L:L:?2 R:R:L382 5.3 2 Yes Yes 0 5 0 1
L:L:?2 R:R:D385 5.2 2 Yes No 0 7 0 1
L:L:?2 R:R:L386 3.98 2 Yes Yes 0 7 0 1
L:L:Q3 L:L:T7 4.25 2 Yes No 0 0 1 2
L:L:Q3 R:R:Y145 6.76 2 Yes Yes 0 7 1 2
L:L:Q3 R:R:Y149 3.38 2 Yes Yes 0 8 1 2
L:L:Q3 R:R:L386 2.66 2 Yes Yes 0 7 1 1
L:L:G4 R:R:W304 2.81 2 No Yes 0 6 2 2
L:L:T5 R:R:W304 3.64 2 Yes Yes 0 6 1 2
L:L:T5 R:R:D370 5.78 2 Yes Yes 0 4 1 2
L:L:T5 R:R:R378 2.59 2 Yes Yes 0 4 1 2
L:L:T5 R:R:L382 4.42 2 Yes Yes 0 5 1 1
L:L:F6 R:R:Y145 6.19 2 Yes Yes 0 7 2 2
L:L:F6 R:R:L382 7.31 2 Yes Yes 0 5 2 1
L:L:F6 R:R:L386 9.74 2 Yes Yes 0 7 2 1
R:R:Y145 R:R:Y149 5.96 2 Yes Yes 7 8 2 2
R:R:Q232 R:R:W304 4.38 2 Yes Yes 7 6 2 2
R:R:F365 R:R:K381 4.96 2 Yes No 7 7 2 2
R:R:D385 R:R:F365 11.94 2 No Yes 7 7 1 2
R:R:D370 R:R:R378 3.57 2 Yes Yes 4 4 2 2
R:R:D370 R:R:K381 8.3 2 Yes No 4 7 2 2
R:R:D385 R:R:K381 9.68 2 No No 7 7 1 2
R:R:L382 R:R:L386 2.77 2 Yes Yes 5 7 1 1
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub5.00
Average Interaction Strength4.78
Average Nodes In Shell19.00
Average Hubs In Shell14.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell30.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7VAB B1 Peptide Glucagon GIP Homo sapiens Non-Acylated Tirzepatide - chim(NtGi1-Gs)/Beta1/Gamma2 3.2 2022-03-02 10.1038/s41467-022-28683-0

A 2D representation of the interactions of AIB in 7VAB
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:F6 R:R:L134 6.09 2 Yes No 0 5 1 2
R:R:L137 R:R:L374 2.77 2 No No 6 6 2 2
L:L:F6 R:R:L137 3.65 2 Yes No 0 6 1 2
R:R:Q138 R:R:Y141 4.51 2 Yes Yes 5 7 2 2
L:L:F6 R:R:Q138 2.34 2 Yes Yes 0 5 1 2
R:R:Y141 R:R:Y145 4.96 2 Yes Yes 7 7 2 2
R:R:I187 R:R:Y141 2.42 2 Yes Yes 7 7 2 2
R:R:I378 R:R:Y141 3.63 2 Yes Yes 8 7 1 2
L:L:F6 R:R:Y141 7.22 2 Yes Yes 0 7 1 2
R:R:I187 R:R:Y145 8.46 2 Yes Yes 7 7 2 2
L:L:E3 R:R:Y145 3.37 2 Yes Yes 0 7 1 2
L:L:E3 R:R:I187 2.73 2 Yes Yes 0 7 1 2
R:R:I299 R:R:Q224 5.49 2 No Yes 7 6 2 2
L:L:Y1 R:R:Q224 13.53 2 Yes Yes 0 6 1 2
L:L:Y1 R:R:V227 6.31 2 Yes No 0 6 1 2
L:L:Y1 R:R:W296 4.82 2 Yes No 0 6 1 2
L:L:Y1 R:R:I299 2.42 2 Yes No 0 7 1 2
L:L:Y1 R:R:I303 3.63 2 Yes No 0 7 1 2
R:R:E377 R:R:K373 9.45 0 No No 7 7 1 2
R:R:I378 R:R:L374 4.28 2 Yes No 8 6 1 2
L:L:F6 R:R:L374 6.09 2 Yes No 0 6 1 2
L:L:?2 R:R:E377 6.35 2 Yes No 0 7 0 1
L:L:?2 R:R:I378 2.73 2 Yes Yes 0 8 0 1
L:L:F6 R:R:I378 5.02 2 Yes Yes 0 8 1 1
L:L:?2 L:L:Y1 2.25 2 Yes Yes 0 0 0 1
L:L:E3 L:L:Y1 2.24 2 Yes Yes 0 0 1 1
L:L:G4 L:L:Y1 5.79 0 No Yes 0 0 2 1
L:L:?2 L:L:E3 11.42 2 Yes Yes 0 0 0 1
L:L:?2 L:L:T5 7.06 2 Yes No 0 0 0 1
L:L:?2 L:L:F6 2.33 2 Yes Yes 0 0 0 1
L:L:D9 L:L:T5 2.89 0 No No 0 0 2 1
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub4.00
Average Interaction Strength5.36
Average Nodes In Shell22.00
Average Hubs In Shell10.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell28.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of AIB in 7VAB
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:K16 R:R:F127 9.93 0 No No 0 2 1 2
L:L:L14 R:R:R131 2.43 0 No No 0 3 1 2
L:L:I17 R:R:R131 2.51 0 No No 0 3 1 2
L:L:?13 L:L:I12 2.73 0 Yes No 0 0 0 1
L:L:?13 L:L:L14 2.65 0 Yes No 0 0 0 1
L:L:?13 L:L:K16 5.4 0 Yes No 0 0 0 1
L:L:?13 L:L:I17 4.1 0 Yes No 0 0 0 1
L:L:L14 R:R:P197 1.64 0 No No 0 4 1 2
L:L:I17 L:L:K20 1.45 0 No No 0 0 1 2
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub0.00
Average Interaction Strength3.72
Average Nodes In Shell9.00
Average Hubs In Shell1.00
Average Links In Shell9.00
Average Links Mediated by Hubs In Shell4.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7VBH B1 Peptide Glucagon GLP-1 Homo sapiens Peptide-20 - Gs/Beta1/Gamma2 3 2022-04-06 10.1038/s41467-022-28683-0

A 2D representation of the interactions of AIB in 7VBH
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 L:L:H1 6.16 2 Yes Yes 0 0 0 1
L:L:G4 L:L:H1 4.77 2 No Yes 0 0 2 1
L:L:H1 R:R:Q234 11.13 2 Yes Yes 0 7 1 2
L:L:H1 R:R:W306 22.22 2 Yes Yes 0 6 1 2
L:L:?2 L:L:Q3 3.82 2 Yes Yes 0 0 0 1
L:L:?2 L:L:T5 15.53 2 Yes Yes 0 0 0 1
L:L:?2 R:R:L384 5.3 2 Yes Yes 0 5 0 1
L:L:?2 R:R:L388 5.3 2 Yes Yes 0 7 0 1
L:L:F6 L:L:Q3 3.51 2 No Yes 0 0 2 1
L:L:Q3 R:R:Y148 14.65 2 Yes Yes 0 7 1 2
L:L:Q3 R:R:Y152 3.38 2 Yes Yes 0 7 1 2
L:L:Q3 R:R:V194 5.73 2 Yes No 0 7 1 2
L:L:Q3 R:R:K197 10.85 2 Yes Yes 0 6 1 2
L:L:Q3 R:R:L388 5.32 2 Yes Yes 0 7 1 1
L:L:G4 R:R:W306 5.63 2 No Yes 0 6 2 2
L:L:T5 R:R:D372 7.23 2 Yes Yes 0 5 1 2
L:L:T5 R:R:R380 7.76 2 Yes Yes 0 5 1 2
L:L:T5 R:R:L384 7.37 2 Yes Yes 0 5 1 1
L:L:F6 R:R:Y148 10.32 2 No Yes 0 7 2 2
R:R:L144 R:R:L384 5.54 2 No Yes 6 5 2 1
R:R:L144 R:R:L388 5.54 2 No Yes 6 7 2 1
R:R:Y148 R:R:Y152 4.96 2 Yes Yes 7 7 2 2
R:R:K197 R:R:Y148 3.58 2 Yes Yes 6 7 2 2
R:R:L388 R:R:Y148 9.38 2 Yes Yes 7 7 1 2
R:R:V194 R:R:Y152 11.36 2 No Yes 7 7 2 2
R:R:Q234 R:R:W306 4.38 2 Yes Yes 7 6 2 2
R:R:D372 R:R:W306 6.7 2 Yes Yes 5 6 2 2
R:R:D372 R:R:R380 5.96 2 Yes Yes 5 5 2 2
R:R:L384 R:R:L388 4.15 2 Yes Yes 5 7 1 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.22
Average Nodes In Shell17.00
Average Hubs In Shell13.00
Average Links In Shell29.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7VBI B1 Peptide Glucagon GLP-1 Homo sapiens Non-Acylated Tirzepatide - Gs/Beta1/Gamma2 3 2022-03-02 10.1038/s41467-022-28683-0

A 2D representation of the interactions of AIB in 7VBI
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 L:L:Y1 6.74 1 Yes Yes 0 0 0 1
L:L:E3 L:L:Y1 3.37 1 Yes Yes 0 0 1 1
L:L:G4 L:L:Y1 5.79 1 No Yes 0 0 1 1
L:L:Y1 R:R:Q234 11.27 1 Yes Yes 0 7 1 2
L:L:Y1 R:R:V237 8.83 1 Yes No 0 6 1 2
L:L:Y1 R:R:W306 5.79 1 Yes Yes 0 6 1 2
L:L:?2 L:L:E3 11.42 1 Yes Yes 0 0 0 1
L:L:?2 L:L:G4 3.28 1 Yes No 0 0 0 1
L:L:?2 L:L:T5 4.24 1 Yes No 0 0 0 1
L:L:?2 R:R:E387 6.35 1 Yes No 0 8 0 1
L:L:?2 R:R:L388 3.98 1 Yes Yes 0 7 0 1
L:L:E3 R:R:Y152 8.98 1 Yes Yes 0 7 1 2
L:L:E3 R:R:R190 8.14 1 Yes Yes 0 8 1 2
L:L:E3 R:R:L388 3.98 1 Yes Yes 0 7 1 1
L:L:T5 R:R:W306 4.85 1 No Yes 0 6 1 2
L:L:T5 R:R:D372 14.45 1 No Yes 0 5 1 2
L:L:F6 R:R:Y148 8.25 1 Yes Yes 0 7 2 2
L:L:F6 R:R:L388 3.65 1 Yes Yes 0 7 2 1
R:R:Y148 R:R:Y152 4.96 1 Yes Yes 7 7 2 2
R:R:L388 R:R:Y148 3.52 1 Yes Yes 7 7 1 2
R:R:R190 R:R:Y152 7.2 1 Yes Yes 8 7 2 2
R:R:R190 R:R:V237 10.46 1 Yes No 8 6 2 2
R:R:D372 R:R:W306 5.58 1 Yes Yes 5 6 2 2
R:R:F367 R:R:T386 10.38 1 Yes No 7 4 2 2
R:R:E387 R:R:F367 5.83 1 No Yes 8 7 1 2
R:R:E387 R:R:T386 5.64 1 No No 8 4 1 2
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub3.00
Average Interaction Strength6.00
Average Nodes In Shell17.00
Average Hubs In Shell12.00
Average Links In Shell26.00
Average Links Mediated by Hubs In Shell25.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of AIB in 7VBI
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:L14 L:L:Y10 12.89 0 No No 0 0 1 2
L:L:?13 L:L:L14 5.3 0 No No 0 0 0 1
L:L:?13 L:L:K16 5.4 0 No No 0 0 0 1
L:L:?13 L:L:I17 6.84 0 No No 0 0 0 1
L:L:L14 R:R:Y205 8.21 0 No Yes 0 3 1 2
L:L:K16 L:L:K20 7.18 0 No No 0 0 1 2
L:L:K16 R:R:W91 3.48 0 No Yes 0 4 1 2
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub0.00
Average Interaction Strength5.85
Average Nodes In Shell8.00
Average Hubs In Shell2.00
Average Links In Shell7.00
Average Links Mediated by Hubs In Shell2.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7Y35 B1 Peptide Parathyroid hormone PTH1 Homo sapiens Abaloparatide - Gs/Beta1/Gamma2 2.9 2023-07-05  To be published

A 2D representation of the interactions of AIB in 7Y35
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?29 L:L:K30 4.05 4 Yes No 0 0 0 1
L:L:?29 L:L:T33 8.47 4 Yes No 0 0 0 1
L:L:?29 L:L:?34 9.91 4 Yes No 0 0 0 1
L:L:H32 L:L:T33 2.74 4 Yes No 0 0 2 1
L:L:?34 L:L:T33 11.02 4 No No 0 0 1 1
L:L:?29 L:L:E25 1.27 4 Yes No 0 0 0 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub0.00
Average Interaction Strength5.92
Average Nodes In Shell6.00
Average Hubs In Shell2.00
Average Links In Shell6.00
Average Links Mediated by Hubs In Shell5.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8FLS B1 Peptide Parathyroid hormone PTH1 Homo Sapiens Abaloparatide - Gs/Beta1/Gamma2 3.09 2023-04-26 10.1016/j.str.2023.04.002

A 2D representation of the interactions of AIB in 8FLS
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:L28 R:R:Y167 3.52 0 No Yes 0 5 1 2
L:L:?29 L:L:K30 4.05 0 No No 0 0 0 1
L:L:?29 R:R:R162 4.65 0 No No 0 3 0 1
L:L:L28 R:R:V171 2.98 0 No No 0 3 1 2
L:L:?29 L:L:L28 2.65 0 No No 0 0 0 1
L:L:K26 L:L:K30 1.44 0 No No 0 0 2 1
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub0.00
Average Interaction Strength3.78
Average Nodes In Shell7.00
Average Hubs In Shell1.00
Average Links In Shell6.00
Average Links Mediated by Hubs In Shell1.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8FLT B1 Peptide Parathyroid hormone PTH1 Homo Sapiens M-PTH(1-14) - Gs/Beta1/Gamma2 3.03 2023-04-26 10.1016/j.str.2023.04.002

A 2D representation of the interactions of AIB in 8FLT
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:V2 5.71 1 Yes No 0 0 0 1
L:L:?1 L:L:Q6 3.82 1 Yes Yes 0 0 0 1
L:L:?1 R:R:W361 3.27 1 Yes Yes 0 8 0 1
L:L:?1 R:R:Q364 5.1 1 Yes Yes 0 7 0 1
L:L:?1 R:R:L368 6.63 1 Yes No 0 4 0 1
L:L:I5 L:L:V2 9.22 1 No No 0 0 2 1
L:L:V2 R:R:Q364 8.6 1 No Yes 0 7 1 1
L:L:I5 R:R:Q364 13.72 1 No Yes 0 7 2 1
L:L:Q10 L:L:Q6 7.68 1 Yes Yes 0 0 2 1
L:L:Q6 R:R:Y429 19.16 1 Yes Yes 0 6 1 2
L:L:Q6 R:R:Q440 5.12 1 Yes Yes 0 6 1 2
L:L:Q6 R:R:M441 6.8 1 Yes Yes 0 6 1 2
L:L:Q10 R:R:Y429 4.51 1 Yes Yes 0 6 2 2
R:R:N358 R:R:W361 4.52 0 No Yes 4 8 2 1
R:R:K360 R:R:W361 6.96 1 Yes Yes 7 8 2 1
R:R:K360 R:R:Q364 4.07 1 Yes Yes 7 7 2 1
R:R:K360 R:R:Y429 16.72 1 Yes Yes 7 6 2 2
R:R:Q364 R:R:W361 7.67 1 Yes Yes 7 8 1 1
R:R:V365 R:R:W361 6.13 0 No Yes 5 8 2 1
R:R:Q364 R:R:Y429 10.15 1 Yes Yes 7 6 1 2
R:R:M441 R:R:Q440 4.08 1 Yes Yes 6 6 2 2
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub3.00
Average Interaction Strength4.91
Average Nodes In Shell14.00
Average Hubs In Shell9.00
Average Links In Shell21.00
Average Links Mediated by Hubs In Shell20.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of AIB in 8FLT
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?3 L:L:E4 5.08 1 Yes Yes 0 0 0 1
L:L:?3 R:R:M441 4.06 1 Yes Yes 0 6 0 1
L:L:?3 R:R:E444 16.5 1 Yes No 0 7 0 1
L:L:?3 R:R:M445 5.42 1 Yes Yes 0 6 0 1
L:L:E4 R:R:Y195 4.49 1 Yes Yes 0 7 1 2
L:L:E4 R:R:R233 6.98 1 Yes Yes 0 8 1 2
L:L:E4 R:R:I237 4.1 1 Yes Yes 0 7 1 2
L:L:E4 R:R:L292 5.3 1 Yes No 0 6 1 2
L:L:E4 R:R:M445 8.12 1 Yes Yes 0 6 1 1
L:L:E4 R:R:N448 6.57 1 Yes Yes 0 6 1 2
L:L:Q6 R:R:Q440 5.12 1 Yes Yes 0 6 2 2
L:L:Q6 R:R:M441 6.8 1 Yes Yes 0 6 2 1
L:L:L7 R:R:M445 4.24 0 No Yes 0 6 2 1
R:R:L187 R:R:M441 4.24 0 No Yes 5 6 2 1
R:R:Y191 R:R:Y195 5.96 0 Yes Yes 7 7 2 2
R:R:M445 R:R:Y191 8.38 1 Yes Yes 6 7 1 2
R:R:R233 R:R:Y195 11.32 1 Yes Yes 8 7 2 2
R:R:I237 R:R:Y195 8.46 1 Yes Yes 7 7 2 2
R:R:L292 R:R:R233 7.29 1 No Yes 6 8 2 2
R:R:N448 R:R:R233 6.03 1 Yes Yes 6 8 2 2
R:R:F424 R:R:Q440 9.37 1 Yes Yes 7 6 2 2
R:R:E444 R:R:F424 7 1 No Yes 7 7 1 2
R:R:M441 R:R:W437 22.1 1 Yes Yes 6 5 1 2
R:R:M441 R:R:Q440 4.08 1 Yes Yes 6 6 1 2
R:R:E444 R:R:Q440 5.1 1 No Yes 7 6 1 2
R:R:I190 R:R:M445 2.92 0 No Yes 6 6 2 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.77
Average Nodes In Shell18.00
Average Hubs In Shell13.00
Average Links In Shell26.00
Average Links Mediated by Hubs In Shell26.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links4.40
Average Number Of Links With An Hub1.84
Average Interaction Strength5.90
Average Nodes In Shell13.04
Average Hubs In Shell7.00
Average Links In Shell17.64
Average Links Mediated by Hubs In Shell15.40

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)