Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 6FJ3 | B1 | Peptide | Parathyroid hormone | PTH1 | Homo sapiens | PTH | - | - | 2.5 | 2018-11-21 | 10.1038/s41594-018-0151-4 |
![](/psngpcr/ligands/AIB/AIB_6FJ3_L_L_3.png)
A 2D representation of the interactions of AIB in 6FJ3 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:L187 | R:R:M441 | 4.24 | 0 | No | No | 5 | 6 | 2 | 1 | R:R:R233 | R:R:Y195 | 8.23 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | L:L:E4 | R:R:Y195 | 5.61 | 1 | Yes | Yes | 0 | 7 | 1 | 2 | R:R:F288 | R:R:R233 | 6.41 | 1 | Yes | Yes | 7 | 8 | 2 | 2 | R:R:L292 | R:R:R233 | 3.64 | 1 | No | Yes | 6 | 8 | 2 | 2 | R:R:N448 | R:R:R233 | 3.62 | 1 | Yes | Yes | 6 | 8 | 2 | 2 | L:L:V2 | R:R:R233 | 3.92 | 1 | Yes | Yes | 0 | 8 | 1 | 2 | L:L:E4 | R:R:R233 | 5.82 | 1 | Yes | Yes | 0 | 8 | 1 | 2 | L:L:E4 | R:R:F288 | 5.83 | 1 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:V2 | R:R:L292 | 4.47 | 1 | Yes | No | 0 | 6 | 1 | 2 | R:R:F424 | R:R:R440 | 4.28 | 1 | Yes | Yes | 7 | 6 | 2 | 2 | R:R:E444 | R:R:F424 | 31.48 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | R:R:M441 | R:R:W437 | 17.45 | 0 | No | No | 6 | 5 | 1 | 2 | R:R:E444 | R:R:R440 | 11.63 | 1 | Yes | Yes | 7 | 6 | 1 | 2 | L:L:?3 | R:R:M441 | 4.06 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:E444 | R:R:N448 | 6.57 | 1 | Yes | Yes | 7 | 6 | 1 | 2 | L:L:?3 | R:R:E444 | 20.31 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?3 | R:R:M445 | 6.77 | 1 | Yes | No | 0 | 6 | 0 | 1 | L:L:E4 | R:R:M445 | 4.06 | 1 | Yes | No | 0 | 6 | 1 | 1 | L:L:E4 | R:R:N448 | 11.83 | 1 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:?1 | L:L:V2 | 8.76 | 0 | Yes | Yes | 0 | 0 | 2 | 1 | L:L:?3 | L:L:V2 | 4.28 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:E4 | L:L:V2 | 9.98 | 1 | Yes | Yes | 0 | 0 | 1 | 1 | L:L:?3 | L:L:E4 | 11.42 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | R:R:C191 | R:R:M445 | 3.24 | 0 | No | No | 7 | 6 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 5.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 9.37 | Average Nodes In Shell | 17.00 | Average Hubs In Shell | 11.00 | Average Links In Shell | 25.00 | Average Links Mediated by Hubs In Shell | 22.00 |
| ![](/psngpcr/ligands/AIB/AIB_6FJ3_L_L_3_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_6FJ3_L_L_3_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7FIM | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Tirzepatide | - | Gs/Beta1/Gamma2 | 3.4 | 2022-03-02 | 10.1038/s41467-022-28683-0 |
![](/psngpcr/ligands/AIB/AIB_7FIM_L_L_2.png)
A 2D representation of the interactions of AIB in 7FIM colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:R190 | R:R:Y152 | 5.14 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | R:R:V194 | R:R:Y152 | 8.83 | 1 | No | Yes | 7 | 7 | 2 | 2 | L:L:E3 | R:R:Y152 | 4.49 | 1 | Yes | Yes | 0 | 7 | 1 | 2 | R:R:R190 | R:R:V237 | 6.54 | 1 | Yes | No | 8 | 6 | 2 | 2 | L:L:E3 | R:R:R190 | 9.3 | 1 | Yes | Yes | 0 | 8 | 1 | 2 | R:R:M233 | R:R:V194 | 3.04 | 1 | Yes | No | 6 | 7 | 2 | 2 | L:L:E3 | R:R:V194 | 4.28 | 1 | Yes | No | 0 | 7 | 1 | 2 | L:L:E3 | R:R:M233 | 4.06 | 1 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:E3 | R:R:V237 | 5.7 | 1 | Yes | No | 0 | 6 | 1 | 2 | L:L:T5 | R:R:W306 | 4.85 | 0 | No | Yes | 0 | 6 | 1 | 2 | R:R:F367 | R:R:T386 | 6.49 | 1 | Yes | No | 7 | 4 | 2 | 2 | R:R:E387 | R:R:F367 | 11.66 | 1 | Yes | Yes | 8 | 7 | 1 | 2 | R:R:E387 | R:R:T386 | 5.64 | 1 | Yes | No | 8 | 4 | 1 | 2 | L:L:?2 | R:R:L388 | 3.98 | 0 | Yes | No | 0 | 7 | 0 | 1 | L:L:F6 | R:R:L388 | 4.87 | 16 | Yes | No | 0 | 7 | 2 | 1 | L:L:?2 | L:L:E3 | 3.81 | 0 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?2 | L:L:T5 | 8.47 | 0 | Yes | No | 0 | 0 | 0 | 1 | R:R:E364 | R:R:E387 | 2.54 | 1 | Yes | Yes | 8 | 8 | 2 | 1 | L:L:?2 | R:R:E387 | 2.54 | 0 | Yes | Yes | 0 | 8 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 4.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 4.70 | Average Nodes In Shell | 15.00 | Average Hubs In Shell | 10.00 | Average Links In Shell | 19.00 | Average Links Mediated by Hubs In Shell | 19.00 |
| ![](/psngpcr/ligands/AIB/AIB_7FIM_L_L_2_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_7FIM_L_L_2_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/AIB/AIB_7FIM_L_L_13.png)
A 2D representation of the interactions of AIB in 7FIM colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:L14 | R:R:Y205 | 5.86 | 0 | No | No | 0 | 3 | 1 | 2 | L:L:I12 | R:R:R299 | 3.76 | 0 | No | Yes | 0 | 4 | 1 | 2 | L:L:L14 | L:L:Y10 | 4.69 | 0 | No | Yes | 0 | 0 | 1 | 2 | L:L:?13 | L:L:I12 | 5.47 | 0 | No | No | 0 | 0 | 0 | 1 | L:L:?13 | L:L:L14 | 3.98 | 0 | No | No | 0 | 0 | 0 | 1 | L:L:?13 | L:L:I17 | 5.47 | 0 | No | No | 0 | 0 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 3.00 | Average Number Of Links With An Hub | 0.00 | Average Interaction Strength | 4.97 | Average Nodes In Shell | 7.00 | Average Hubs In Shell | 2.00 | Average Links In Shell | 6.00 | Average Links Mediated by Hubs In Shell | 2.00 |
| ![](/psngpcr/ligands/AIB/AIB_7FIM_L_L_13_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_7FIM_L_L_13_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7FIN | B1 | Peptide | Glucagon | GIP | Homo sapiens | Peptide-20; GGL | - | Gs/Beta1/Gamma2 | 3.1 | 2022-02-23 | 10.1038/s41467-022-28683-0 |
![](/psngpcr/ligands/AIB/AIB_7FIN_L_L_2.png)
A 2D representation of the interactions of AIB in 7FIN colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:Y141 | R:R:Y145 | 5.96 | 5 | Yes | Yes | 7 | 7 | 2 | 2 | L:L:Q3 | R:R:Y141 | 4.51 | 5 | Yes | Yes | 0 | 7 | 1 | 2 | R:R:I187 | R:R:Y145 | 7.25 | 5 | No | Yes | 7 | 7 | 2 | 2 | L:L:Q3 | R:R:Y145 | 10.15 | 5 | Yes | Yes | 0 | 7 | 1 | 2 | R:R:I187 | R:R:R183 | 5.01 | 5 | No | Yes | 7 | 8 | 2 | 2 | R:R:R183 | R:R:V227 | 6.54 | 5 | Yes | No | 8 | 6 | 2 | 2 | L:L:H1 | R:R:R183 | 5.64 | 5 | Yes | Yes | 0 | 8 | 1 | 2 | L:L:Q3 | R:R:I187 | 9.61 | 5 | Yes | No | 0 | 7 | 1 | 2 | L:L:H1 | R:R:V227 | 13.84 | 5 | Yes | No | 0 | 6 | 1 | 2 | L:L:G4 | R:R:W296 | 2.81 | 5 | No | Yes | 0 | 6 | 1 | 2 | L:L:T5 | R:R:W296 | 3.64 | 0 | No | Yes | 0 | 6 | 1 | 2 | R:R:F357 | R:R:K373 | 4.96 | 5 | No | Yes | 7 | 7 | 2 | 2 | R:R:E377 | R:R:F357 | 32.65 | 5 | No | No | 7 | 7 | 1 | 2 | R:R:E377 | R:R:K373 | 2.7 | 5 | No | Yes | 7 | 7 | 1 | 2 | L:L:?2 | R:R:E377 | 7.62 | 5 | Yes | No | 0 | 7 | 0 | 1 | L:L:?2 | L:L:H1 | 4.93 | 5 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:H1 | L:L:Q3 | 3.71 | 5 | Yes | Yes | 0 | 0 | 1 | 1 | L:L:G4 | L:L:H1 | 3.18 | 5 | No | Yes | 0 | 0 | 1 | 1 | L:L:?2 | L:L:Q3 | 2.55 | 5 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?2 | L:L:G4 | 3.28 | 5 | Yes | No | 0 | 0 | 0 | 1 | L:L:?2 | L:L:T5 | 7.06 | 5 | Yes | No | 0 | 0 | 0 | 1 | L:L:D9 | L:L:T5 | 2.89 | 0 | No | No | 0 | 0 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 5.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 5.09 | Average Nodes In Shell | 15.00 | Average Hubs In Shell | 8.00 | Average Links In Shell | 22.00 | Average Links Mediated by Hubs In Shell | 20.00 |
| ![](/psngpcr/ligands/AIB/AIB_7FIN_L_L_2_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_7FIN_L_L_2_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7FIY | B1 | Peptide | Glucagon | GIP | Homo sapiens | Tirzepatide | - | Gs/Beta1/Gamma2 | 3.4 | 2022-03-02 | 10.1038/s41467-022-28683-0 |
![](/psngpcr/ligands/AIB/AIB_7FIY_L_L_2.png)
A 2D representation of the interactions of AIB in 7FIY colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:E3 | R:R:Y145 | 3.37 | 4 | Yes | Yes | 0 | 7 | 1 | 2 | R:R:R183 | R:R:V227 | 5.23 | 4 | Yes | No | 8 | 6 | 2 | 2 | R:R:R183 | R:R:S381 | 5.27 | 4 | Yes | No | 8 | 5 | 2 | 2 | L:L:Y1 | R:R:R183 | 3.09 | 4 | Yes | Yes | 0 | 8 | 1 | 2 | L:L:E3 | R:R:R183 | 9.3 | 4 | Yes | Yes | 0 | 8 | 1 | 2 | L:L:Y1 | R:R:Q224 | 5.64 | 4 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:Y1 | R:R:V227 | 16.4 | 4 | Yes | No | 0 | 6 | 1 | 2 | R:R:R300 | R:R:W296 | 13 | 21 | Yes | Yes | 7 | 6 | 2 | 2 | L:L:Y1 | R:R:W296 | 2.89 | 4 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:T5 | R:R:R300 | 5.17 | 0 | No | Yes | 0 | 7 | 1 | 2 | L:L:E3 | R:R:S381 | 7.19 | 4 | Yes | No | 0 | 5 | 1 | 2 | L:L:?2 | L:L:Y1 | 3.37 | 4 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:E3 | L:L:Y1 | 7.86 | 4 | Yes | Yes | 0 | 0 | 1 | 1 | L:L:G4 | L:L:Y1 | 5.79 | 4 | No | Yes | 0 | 0 | 1 | 1 | L:L:?2 | L:L:E3 | 12.69 | 4 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?2 | L:L:G4 | 3.28 | 4 | Yes | No | 0 | 0 | 0 | 1 | L:L:?2 | L:L:T5 | 8.47 | 4 | Yes | No | 0 | 0 | 0 | 1 | L:L:G4 | L:L:T7 | 3.64 | 4 | No | No | 0 | 0 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 4.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 6.95 | Average Nodes In Shell | 13.00 | Average Hubs In Shell | 8.00 | Average Links In Shell | 18.00 | Average Links Mediated by Hubs In Shell | 17.00 |
| ![](/psngpcr/ligands/AIB/AIB_7FIY_L_L_2_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_7FIY_L_L_2_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/AIB/AIB_7FIY_L_L_13.png)
A 2D representation of the interactions of AIB in 7FIY colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:P197 | R:R:R196 | 2.88 | 14 | Yes | No | 4 | 3 | 2 | 2 | L:L:Y10 | R:R:R196 | 3.09 | 14 | No | No | 0 | 3 | 2 | 2 | L:L:L14 | R:R:R196 | 8.5 | 14 | Yes | No | 0 | 3 | 1 | 2 | L:L:L14 | R:R:P197 | 3.28 | 14 | Yes | Yes | 0 | 4 | 1 | 2 | L:L:L14 | L:L:Y10 | 4.69 | 14 | Yes | No | 0 | 0 | 1 | 2 | L:L:?13 | L:L:I12 | 5.47 | 0 | Yes | No | 0 | 0 | 0 | 1 | L:L:?13 | L:L:K16 | 5.4 | 0 | Yes | No | 0 | 0 | 0 | 1 | L:L:?13 | L:L:I17 | 5.47 | 0 | Yes | No | 0 | 0 | 0 | 1 | L:L:?13 | L:L:L14 | 2.65 | 0 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:I17 | R:R:R131 | 2.51 | 0 | No | No | 0 | 3 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 4.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 4.75 | Average Nodes In Shell | 9.00 | Average Hubs In Shell | 3.00 | Average Links In Shell | 10.00 | Average Links Mediated by Hubs In Shell | 8.00 |
| ![](/psngpcr/ligands/AIB/AIB_7FIY_L_L_13_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_7FIY_L_L_13_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7KI0 | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Semaglutide | - | Gs/Beta1/Gamma2 | 2.5 | 2021-08-04 | 10.1016/j.celrep.2021.109374 |
![](/psngpcr/ligands/AIB/AIB_7KI0_L_L_8.png)
A 2D representation of the interactions of AIB in 7KI0 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:L144 | R:R:L388 | 4.15 | 2 | Yes | Yes | 6 | 7 | 2 | 1 | L:L:F12 | R:R:L144 | 6.09 | 2 | Yes | Yes | 0 | 6 | 2 | 2 | R:R:L388 | R:R:Y148 | 3.52 | 2 | Yes | Yes | 7 | 7 | 1 | 2 | L:L:F12 | R:R:Y148 | 8.25 | 2 | Yes | Yes | 0 | 7 | 2 | 2 | R:R:R190 | R:R:Y152 | 8.23 | 2 | Yes | Yes | 8 | 7 | 2 | 2 | L:L:E9 | R:R:Y152 | 6.73 | 2 | Yes | Yes | 0 | 7 | 1 | 2 | R:R:R190 | R:R:V237 | 6.54 | 2 | Yes | No | 8 | 6 | 2 | 2 | L:L:E9 | R:R:R190 | 11.63 | 2 | Yes | Yes | 0 | 8 | 1 | 2 | L:L:H7 | R:R:Q234 | 8.65 | 2 | Yes | No | 0 | 7 | 1 | 2 | L:L:H7 | R:R:V237 | 15.22 | 2 | Yes | No | 0 | 6 | 1 | 2 | L:L:H7 | R:R:W306 | 8.46 | 2 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:H7 | R:R:I313 | 3.98 | 2 | Yes | No | 0 | 7 | 1 | 2 | R:R:E387 | R:R:F367 | 3.5 | 0 | No | Yes | 8 | 7 | 1 | 2 | L:L:T11 | R:R:D372 | 8.67 | 0 | No | Yes | 0 | 5 | 1 | 2 | R:R:E387 | R:R:K383 | 13.5 | 0 | No | No | 8 | 7 | 1 | 2 | L:L:?8 | R:R:E387 | 8.88 | 2 | Yes | No | 0 | 8 | 0 | 1 | L:L:?8 | R:R:L388 | 3.98 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:E9 | R:R:L388 | 3.98 | 2 | Yes | Yes | 0 | 7 | 1 | 1 | L:L:F12 | R:R:L388 | 3.65 | 2 | Yes | Yes | 0 | 7 | 2 | 1 | L:L:E9 | R:R:T391 | 4.23 | 2 | Yes | No | 0 | 6 | 1 | 2 | L:L:?8 | L:L:H7 | 4.93 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:E9 | L:L:H7 | 3.69 | 2 | Yes | Yes | 0 | 0 | 1 | 1 | L:L:G10 | L:L:H7 | 4.77 | 0 | No | Yes | 0 | 0 | 2 | 1 | L:L:?8 | L:L:E9 | 11.42 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?8 | L:L:T11 | 9.88 | 2 | Yes | No | 0 | 0 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 5.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 7.82 | Average Nodes In Shell | 20.00 | Average Hubs In Shell | 12.00 | Average Links In Shell | 25.00 | Average Links Mediated by Hubs In Shell | 24.00 |
| ![](/psngpcr/ligands/AIB/AIB_7KI0_L_L_8_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_7KI0_L_L_8_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7KI1 | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Taspoglutide | - | Gs/Beta1/Gamma2 | 2.5 | 2021-08-04 | 10.1016/j.celrep.2021.109374 |
![](/psngpcr/ligands/AIB/AIB_7KI1_L_L_8.png)
A 2D representation of the interactions of AIB in 7KI1 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:Q234 | R:R:W306 | 7.67 | 2 | No | Yes | 7 | 6 | 2 | 2 | L:L:H7 | R:R:Q234 | 6.18 | 2 | Yes | No | 0 | 7 | 1 | 2 | L:L:H7 | R:R:V237 | 15.22 | 2 | Yes | No | 0 | 6 | 1 | 2 | R:R:I313 | R:R:Y241 | 10.88 | 2 | No | Yes | 7 | 8 | 2 | 2 | L:L:H7 | R:R:Y241 | 3.27 | 2 | Yes | Yes | 0 | 8 | 1 | 2 | L:L:H7 | R:R:W306 | 7.41 | 2 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:H7 | R:R:I313 | 3.98 | 2 | Yes | No | 0 | 7 | 1 | 2 | L:L:T11 | R:R:D372 | 7.23 | 2 | No | No | 0 | 5 | 1 | 2 | R:R:E387 | R:R:K383 | 4.05 | 0 | No | No | 8 | 7 | 1 | 2 | L:L:?8 | R:R:L384 | 6.63 | 2 | Yes | No | 0 | 5 | 0 | 1 | L:L:T11 | R:R:L384 | 5.9 | 2 | No | No | 0 | 5 | 1 | 1 | L:L:?8 | R:R:E387 | 12.69 | 2 | Yes | No | 0 | 8 | 0 | 1 | L:L:?8 | L:L:H7 | 4.93 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:G10 | L:L:H7 | 3.18 | 0 | No | Yes | 0 | 0 | 2 | 1 | L:L:?8 | L:L:T11 | 11.29 | 2 | Yes | No | 0 | 0 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 4.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 8.88 | Average Nodes In Shell | 13.00 | Average Hubs In Shell | 4.00 | Average Links In Shell | 15.00 | Average Links Mediated by Hubs In Shell | 12.00 |
| ![](/psngpcr/ligands/AIB/AIB_7KI1_L_L_8_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_7KI1_L_L_8_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/AIB/AIB_7KI1_L_L_35.png)
A 2D representation of the interactions of AIB in 7KI1 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?35 | R:R:E68 | 3.81 | 5 | No | No | 0 | 4 | 0 | 1 | L:L:R36 | R:R:E68 | 5.82 | 5 | No | No | 0 | 4 | 1 | 1 | L:L:W31 | R:R:H212 | 7.41 | 5 | Yes | Yes | 0 | 3 | 2 | 2 | L:L:K34 | R:R:H212 | 3.93 | 5 | No | Yes | 0 | 3 | 1 | 2 | L:L:K34 | L:L:W31 | 4.64 | 5 | No | Yes | 0 | 0 | 1 | 2 | L:L:?35 | L:L:K34 | 5.4 | 5 | No | No | 0 | 0 | 0 | 1 | L:L:?35 | L:L:R36 | 5.82 | 5 | No | No | 0 | 0 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 3.00 | Average Number Of Links With An Hub | 0.00 | Average Interaction Strength | 5.01 | Average Nodes In Shell | 6.00 | Average Hubs In Shell | 2.00 | Average Links In Shell | 7.00 | Average Links Mediated by Hubs In Shell | 3.00 |
| ![](/psngpcr/ligands/AIB/AIB_7KI1_L_L_35_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_7KI1_L_L_35_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7RBT | B1 | Peptide | Glucagon | GIP | Homo sapiens | Tirzepatide | PubChem 163183774 | chim(NtGi1-Gs)/Beta1/Gamma2 | 3.08 | 2022-04-13 | 10.1073/pnas.2116506119 |
![](/psngpcr/ligands/AIB/AIB_7RBT_L_L_2.png)
A 2D representation of the interactions of AIB in 7RBT colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?2 | L:L:Y1 | 11.23 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:E3 | L:L:Y1 | 3.37 | 2 | Yes | Yes | 0 | 0 | 1 | 1 | L:L:G4 | L:L:Y1 | 5.79 | 2 | No | Yes | 0 | 0 | 1 | 1 | L:L:Y1 | R:R:R183 | 2.06 | 2 | Yes | Yes | 0 | 8 | 1 | 2 | L:L:Y1 | R:R:I187 | 2.42 | 2 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:Y1 | R:R:V227 | 16.4 | 2 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:Y1 | R:R:Y231 | 3.97 | 2 | Yes | Yes | 0 | 8 | 1 | 2 | L:L:Y1 | R:R:W296 | 4.82 | 2 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:?2 | L:L:E3 | 12.69 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?2 | L:L:G4 | 3.28 | 2 | Yes | No | 0 | 0 | 0 | 1 | L:L:?2 | L:L:T5 | 2.82 | 2 | Yes | No | 0 | 0 | 0 | 1 | L:L:?2 | R:R:E377 | 3.81 | 2 | Yes | No | 0 | 7 | 0 | 1 | L:L:?2 | R:R:I378 | 6.84 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:?2 | R:R:S381 | 2.88 | 2 | Yes | No | 0 | 5 | 0 | 1 | L:L:E3 | R:R:Y145 | 8.98 | 2 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:E3 | R:R:R183 | 4.65 | 2 | Yes | Yes | 0 | 8 | 1 | 2 | L:L:E3 | R:R:I187 | 8.2 | 2 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:E3 | R:R:I378 | 4.1 | 2 | Yes | Yes | 0 | 8 | 1 | 1 | L:L:E3 | R:R:S381 | 8.62 | 2 | Yes | No | 0 | 5 | 1 | 1 | L:L:D9 | L:L:T5 | 4.34 | 0 | No | No | 0 | 0 | 2 | 1 | L:L:F6 | R:R:Y141 | 14.44 | 2 | Yes | Yes | 0 | 7 | 2 | 2 | L:L:F6 | R:R:I378 | 2.51 | 2 | Yes | Yes | 0 | 8 | 2 | 1 | R:R:I378 | R:R:M140 | 4.37 | 2 | Yes | No | 8 | 6 | 1 | 2 | R:R:Y141 | R:R:Y145 | 5.96 | 2 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:I378 | R:R:Y141 | 3.63 | 2 | Yes | Yes | 8 | 7 | 1 | 2 | R:R:R183 | R:R:Y145 | 3.09 | 2 | Yes | Yes | 8 | 7 | 2 | 2 | R:R:I187 | R:R:R183 | 2.51 | 2 | Yes | Yes | 7 | 8 | 2 | 2 | R:R:R183 | R:R:V227 | 9.15 | 2 | Yes | Yes | 8 | 6 | 2 | 2 | R:R:R183 | R:R:Y231 | 6.17 | 2 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:R183 | R:R:S381 | 3.95 | 2 | Yes | No | 8 | 5 | 2 | 1 | R:R:I187 | R:R:V227 | 3.07 | 2 | Yes | Yes | 7 | 6 | 2 | 2 | R:R:V227 | R:R:Y231 | 2.52 | 2 | Yes | Yes | 6 | 8 | 2 | 2 | R:R:E377 | R:R:F357 | 15.16 | 0 | No | Yes | 7 | 7 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 7.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 6.22 | Average Nodes In Shell | 19.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 33.00 | Average Links Mediated by Hubs In Shell | 32.00 |
| ![](/psngpcr/ligands/AIB/AIB_7RBT_L_L_2_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_7RBT_L_L_2_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/AIB/AIB_7RBT_L_L_13.png)
A 2D representation of the interactions of AIB in 7RBT colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:L14 | L:L:Y10 | 8.21 | 0 | Yes | Yes | 0 | 0 | 1 | 2 | L:L:?13 | L:L:I12 | 6.84 | 7 | Yes | No | 0 | 0 | 0 | 1 | L:L:I12 | L:L:K16 | 4.36 | 7 | No | No | 0 | 0 | 1 | 1 | L:L:I12 | R:R:R289 | 8.77 | 7 | No | Yes | 0 | 4 | 1 | 2 | L:L:?13 | L:L:L14 | 3.98 | 7 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?13 | L:L:K16 | 2.7 | 7 | Yes | No | 0 | 0 | 0 | 1 | L:L:?13 | L:L:I17 | 4.1 | 7 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?13 | R:R:F127 | 2.33 | 7 | Yes | No | 0 | 2 | 0 | 1 | L:L:L14 | R:R:R131 | 2.43 | 0 | Yes | Yes | 0 | 3 | 1 | 2 | L:L:L14 | R:R:P197 | 1.64 | 0 | Yes | No | 0 | 4 | 1 | 2 | L:L:D15 | L:L:K16 | 4.15 | 0 | Yes | No | 0 | 0 | 2 | 1 | L:L:D15 | R:R:R289 | 4.76 | 0 | Yes | Yes | 0 | 4 | 2 | 2 | L:L:I17 | L:L:K20 | 2.91 | 7 | Yes | No | 0 | 0 | 1 | 2 | L:L:I17 | R:R:L128 | 2.85 | 7 | Yes | No | 0 | 3 | 1 | 2 | L:L:I17 | R:R:R131 | 3.76 | 7 | Yes | Yes | 0 | 3 | 1 | 2 | L:L:K20 | R:R:L128 | 5.64 | 7 | No | No | 0 | 3 | 2 | 2 | R:R:E125 | R:R:F127 | 8.16 | 0 | No | No | 3 | 2 | 2 | 1 | R:R:L128 | R:R:R131 | 2.43 | 7 | No | Yes | 3 | 3 | 2 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 5.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 3.99 | Average Nodes In Shell | 14.00 | Average Hubs In Shell | 7.00 | Average Links In Shell | 18.00 | Average Links Mediated by Hubs In Shell | 15.00 |
| ![](/psngpcr/ligands/AIB/AIB_7RBT_L_L_13_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_7RBT_L_L_13_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7RGP | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Tirzepatide | - | chim(NtGi1-Gs)/Beta1/Gamma2 | 2.9 | 2022-04-13 | 10.1073/pnas.2116506119 |
![](/psngpcr/ligands/AIB/AIB_7RGP_L_L_2.png)
A 2D representation of the interactions of AIB in 7RGP colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?2 | L:L:Y1 | 8.98 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:G4 | L:L:Y1 | 4.35 | 2 | Yes | Yes | 0 | 0 | 1 | 1 | L:L:Y1 | R:R:Q234 | 7.89 | 2 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:Y1 | R:R:V237 | 5.05 | 2 | Yes | No | 0 | 6 | 1 | 2 | L:L:Y1 | R:R:W306 | 9.65 | 2 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:Y1 | R:R:I309 | 3.63 | 2 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:?2 | L:L:E3 | 6.35 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?2 | L:L:G4 | 3.28 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?2 | L:L:T5 | 4.24 | 2 | Yes | No | 0 | 0 | 0 | 1 | L:L:E3 | R:R:Y148 | 12.35 | 2 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:E3 | R:R:Y152 | 7.86 | 2 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:E3 | R:R:R190 | 15.12 | 2 | Yes | Yes | 0 | 8 | 1 | 2 | L:L:E3 | R:R:V194 | 4.28 | 2 | Yes | No | 0 | 7 | 1 | 2 | L:L:G4 | L:L:T7 | 3.64 | 2 | Yes | No | 0 | 0 | 1 | 2 | L:L:G4 | R:R:W306 | 2.81 | 2 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:T5 | R:R:D372 | 4.34 | 0 | No | Yes | 0 | 5 | 1 | 2 | L:L:T5 | R:R:L384 | 7.37 | 0 | No | No | 0 | 5 | 1 | 2 | R:R:Y148 | R:R:Y152 | 14.89 | 2 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:V194 | R:R:Y148 | 7.57 | 2 | No | Yes | 7 | 7 | 2 | 2 | R:R:R190 | R:R:Y152 | 6.17 | 2 | Yes | Yes | 8 | 7 | 2 | 2 | R:R:V194 | R:R:Y152 | 6.31 | 2 | No | Yes | 7 | 7 | 2 | 2 | R:R:R190 | R:R:V237 | 3.92 | 2 | Yes | No | 8 | 6 | 2 | 2 | R:R:Q234 | R:R:W306 | 9.86 | 2 | Yes | Yes | 7 | 6 | 2 | 2 | R:R:I309 | R:R:Q234 | 6.86 | 2 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:I309 | R:R:W306 | 7.05 | 2 | Yes | Yes | 7 | 6 | 2 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 4.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 5.71 | Average Nodes In Shell | 16.00 | Average Hubs In Shell | 11.00 | Average Links In Shell | 25.00 | Average Links Mediated by Hubs In Shell | 24.00 |
| ![](/psngpcr/ligands/AIB/AIB_7RGP_L_L_2_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_7RGP_L_L_2_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/AIB/AIB_7RGP_L_L_13.png)
A 2D representation of the interactions of AIB in 7RGP colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:L14 | L:L:Y10 | 11.72 | 0 | No | Yes | 0 | 0 | 1 | 2 | L:L:?13 | L:L:I12 | 5.47 | 0 | Yes | No | 0 | 0 | 0 | 1 | L:L:?13 | L:L:L14 | 6.63 | 0 | Yes | No | 0 | 0 | 0 | 1 | L:L:?13 | L:L:K16 | 4.05 | 0 | Yes | No | 0 | 0 | 0 | 1 | L:L:?13 | L:L:I17 | 4.1 | 0 | Yes | No | 0 | 0 | 0 | 1 | L:L:L14 | R:R:Y205 | 3.52 | 0 | No | No | 0 | 3 | 1 | 2 | L:L:K16 | L:L:K20 | 5.75 | 0 | No | No | 0 | 0 | 1 | 2 | L:L:I17 | L:L:K20 | 2.91 | 0 | No | No | 0 | 0 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 4.00 | Average Number Of Links With An Hub | 0.00 | Average Interaction Strength | 5.06 | Average Nodes In Shell | 8.00 | Average Hubs In Shell | 2.00 | Average Links In Shell | 8.00 | Average Links Mediated by Hubs In Shell | 5.00 |
| ![](/psngpcr/ligands/AIB/AIB_7RGP_L_L_13_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_7RGP_L_L_13_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7RTB | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Peptide-19 | - | Gs/Beta1/Gamma2 | 2.14 | 2021-10-06 | 10.1016/j.bbrc.2021.09.016 |
![](/psngpcr/ligands/AIB/AIB_7RTB_L_L_2.png)
A 2D representation of the interactions of AIB in 7RTB colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:L314 | R:R:R310 | 7.29 | 37 | No | Yes | 4 | 6 | 2 | 2 | L:L:Y1 | R:R:R310 | 12.35 | 37 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:Y1 | R:R:I313 | 3.63 | 37 | Yes | No | 0 | 7 | 1 | 2 | L:L:Y1 | R:R:L314 | 8.21 | 37 | Yes | No | 0 | 4 | 1 | 2 | L:L:?2 | L:L:Y1 | 8.98 | 0 | No | Yes | 0 | 0 | 0 | 1 | L:L:?2 | L:L:G4 | 3.28 | 0 | No | No | 0 | 0 | 0 | 1 | L:L:?2 | L:L:T5 | 12.71 | 0 | No | No | 0 | 0 | 0 | 1 | L:L:E3 | L:L:G4 | 4.91 | 2 | Yes | No | 0 | 0 | 2 | 1 | L:L:E3 | L:L:T7 | 4.23 | 2 | Yes | No | 0 | 0 | 2 | 2 | L:L:G4 | L:L:T7 | 3.64 | 2 | No | No | 0 | 0 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 3.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 8.32 | Average Nodes In Shell | 9.00 | Average Hubs In Shell | 3.00 | Average Links In Shell | 10.00 | Average Links Mediated by Hubs In Shell | 7.00 |
| ![](/psngpcr/ligands/AIB/AIB_7RTB_L_L_2_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_7RTB_L_L_2_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/AIB/AIB_7RTB_L_L_20.png)
A 2D representation of the interactions of AIB in 7RTB colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?20 | L:L:Q17 | 3.82 | 39 | Yes | No | 0 | 0 | 0 | 1 | L:L:E21 | L:L:Q17 | 16.57 | 39 | No | No | 0 | 0 | 1 | 1 | L:L:?20 | L:L:E21 | 10.15 | 39 | Yes | No | 0 | 0 | 0 | 1 | L:L:?20 | L:L:V23 | 4.28 | 39 | Yes | No | 0 | 0 | 0 | 1 | L:L:E21 | R:R:A209 | 3.02 | 39 | No | No | 0 | 1 | 1 | 2 | L:L:V23 | R:R:L89 | 2.98 | 0 | No | Yes | 0 | 5 | 1 | 2 | L:L:?20 | L:L:N24 | 2.63 | 39 | Yes | No | 0 | 0 | 0 | 1 | L:L:G29 | L:L:N24 | 1.7 | 0 | No | No | 0 | 0 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 4.00 | Average Number Of Links With An Hub | 0.00 | Average Interaction Strength | 5.22 | Average Nodes In Shell | 8.00 | Average Hubs In Shell | 2.00 | Average Links In Shell | 8.00 | Average Links Mediated by Hubs In Shell | 5.00 |
| ![](/psngpcr/ligands/AIB/AIB_7RTB_L_L_20_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_7RTB_L_L_20_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7V35 | B1 | Peptide | Glucagon | Glucagon | Homo sapiens | Peptide-20 | - | Gs/Beta1/Gamma2 | 3.5 | 2022-03-02 | 10.1038/s41467-022-28683-0 |
![](/psngpcr/ligands/AIB/AIB_7V35_L_L_2.png)
A 2D representation of the interactions of AIB in 7V35 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?2 | L:L:H1 | 7.39 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:H1 | L:L:Q3 | 2.47 | 2 | Yes | Yes | 0 | 0 | 1 | 1 | L:L:G4 | L:L:H1 | 4.77 | 2 | No | Yes | 0 | 0 | 2 | 1 | L:L:H1 | R:R:Q232 | 6.18 | 2 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:H1 | R:R:I235 | 11.93 | 2 | Yes | No | 0 | 5 | 1 | 2 | L:L:H1 | R:R:W304 | 3.17 | 2 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:?2 | L:L:Q3 | 2.55 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?2 | L:L:T5 | 4.24 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?2 | R:R:L382 | 5.3 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?2 | R:R:D385 | 5.2 | 2 | Yes | No | 0 | 7 | 0 | 1 | L:L:?2 | R:R:L386 | 3.98 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:Q3 | L:L:T7 | 4.25 | 2 | Yes | No | 0 | 0 | 1 | 2 | L:L:Q3 | R:R:Y145 | 6.76 | 2 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:Q3 | R:R:Y149 | 3.38 | 2 | Yes | Yes | 0 | 8 | 1 | 2 | L:L:Q3 | R:R:L386 | 2.66 | 2 | Yes | Yes | 0 | 7 | 1 | 1 | L:L:G4 | R:R:W304 | 2.81 | 2 | No | Yes | 0 | 6 | 2 | 2 | L:L:T5 | R:R:W304 | 3.64 | 2 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:T5 | R:R:D370 | 5.78 | 2 | Yes | Yes | 0 | 4 | 1 | 2 | L:L:T5 | R:R:R378 | 2.59 | 2 | Yes | Yes | 0 | 4 | 1 | 2 | L:L:T5 | R:R:L382 | 4.42 | 2 | Yes | Yes | 0 | 5 | 1 | 1 | L:L:F6 | R:R:Y145 | 6.19 | 2 | Yes | Yes | 0 | 7 | 2 | 2 | L:L:F6 | R:R:L382 | 7.31 | 2 | Yes | Yes | 0 | 5 | 2 | 1 | L:L:F6 | R:R:L386 | 9.74 | 2 | Yes | Yes | 0 | 7 | 2 | 1 | R:R:Y145 | R:R:Y149 | 5.96 | 2 | Yes | Yes | 7 | 8 | 2 | 2 | R:R:Q232 | R:R:W304 | 4.38 | 2 | Yes | Yes | 7 | 6 | 2 | 2 | R:R:F365 | R:R:K381 | 4.96 | 2 | Yes | No | 7 | 7 | 2 | 2 | R:R:D385 | R:R:F365 | 11.94 | 2 | No | Yes | 7 | 7 | 1 | 2 | R:R:D370 | R:R:R378 | 3.57 | 2 | Yes | Yes | 4 | 4 | 2 | 2 | R:R:D370 | R:R:K381 | 8.3 | 2 | Yes | No | 4 | 7 | 2 | 2 | R:R:D385 | R:R:K381 | 9.68 | 2 | No | No | 7 | 7 | 1 | 2 | R:R:L382 | R:R:L386 | 2.77 | 2 | Yes | Yes | 5 | 7 | 1 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 6.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 4.78 | Average Nodes In Shell | 19.00 | Average Hubs In Shell | 14.00 | Average Links In Shell | 31.00 | Average Links Mediated by Hubs In Shell | 30.00 |
| ![](/psngpcr/ligands/AIB/AIB_7V35_L_L_2_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_7V35_L_L_2_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7VAB | B1 | Peptide | Glucagon | GIP | Homo sapiens | Non-Acylated Tirzepatide | - | chim(NtGi1-Gs)/Beta1/Gamma2 | 3.2 | 2022-03-02 | 10.1038/s41467-022-28683-0 |
![](/psngpcr/ligands/AIB/AIB_7VAB_L_L_2.png)
A 2D representation of the interactions of AIB in 7VAB colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:F6 | R:R:L134 | 6.09 | 2 | Yes | No | 0 | 5 | 1 | 2 | R:R:L137 | R:R:L374 | 2.77 | 2 | No | No | 6 | 6 | 2 | 2 | L:L:F6 | R:R:L137 | 3.65 | 2 | Yes | No | 0 | 6 | 1 | 2 | R:R:Q138 | R:R:Y141 | 4.51 | 2 | Yes | Yes | 5 | 7 | 2 | 2 | L:L:F6 | R:R:Q138 | 2.34 | 2 | Yes | Yes | 0 | 5 | 1 | 2 | R:R:Y141 | R:R:Y145 | 4.96 | 2 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:I187 | R:R:Y141 | 2.42 | 2 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:I378 | R:R:Y141 | 3.63 | 2 | Yes | Yes | 8 | 7 | 1 | 2 | L:L:F6 | R:R:Y141 | 7.22 | 2 | Yes | Yes | 0 | 7 | 1 | 2 | R:R:I187 | R:R:Y145 | 8.46 | 2 | Yes | Yes | 7 | 7 | 2 | 2 | L:L:E3 | R:R:Y145 | 3.37 | 2 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:E3 | R:R:I187 | 2.73 | 2 | Yes | Yes | 0 | 7 | 1 | 2 | R:R:I299 | R:R:Q224 | 5.49 | 2 | No | Yes | 7 | 6 | 2 | 2 | L:L:Y1 | R:R:Q224 | 13.53 | 2 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:Y1 | R:R:V227 | 6.31 | 2 | Yes | No | 0 | 6 | 1 | 2 | L:L:Y1 | R:R:W296 | 4.82 | 2 | Yes | No | 0 | 6 | 1 | 2 | L:L:Y1 | R:R:I299 | 2.42 | 2 | Yes | No | 0 | 7 | 1 | 2 | L:L:Y1 | R:R:I303 | 3.63 | 2 | Yes | No | 0 | 7 | 1 | 2 | R:R:E377 | R:R:K373 | 9.45 | 0 | No | No | 7 | 7 | 1 | 2 | R:R:I378 | R:R:L374 | 4.28 | 2 | Yes | No | 8 | 6 | 1 | 2 | L:L:F6 | R:R:L374 | 6.09 | 2 | Yes | No | 0 | 6 | 1 | 2 | L:L:?2 | R:R:E377 | 6.35 | 2 | Yes | No | 0 | 7 | 0 | 1 | L:L:?2 | R:R:I378 | 2.73 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:F6 | R:R:I378 | 5.02 | 2 | Yes | Yes | 0 | 8 | 1 | 1 | L:L:?2 | L:L:Y1 | 2.25 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:E3 | L:L:Y1 | 2.24 | 2 | Yes | Yes | 0 | 0 | 1 | 1 | L:L:G4 | L:L:Y1 | 5.79 | 0 | No | Yes | 0 | 0 | 2 | 1 | L:L:?2 | L:L:E3 | 11.42 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?2 | L:L:T5 | 7.06 | 2 | Yes | No | 0 | 0 | 0 | 1 | L:L:?2 | L:L:F6 | 2.33 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:D9 | L:L:T5 | 2.89 | 0 | No | No | 0 | 0 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 6.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 5.36 | Average Nodes In Shell | 22.00 | Average Hubs In Shell | 10.00 | Average Links In Shell | 31.00 | Average Links Mediated by Hubs In Shell | 28.00 |
| ![](/psngpcr/ligands/AIB/AIB_7VAB_L_L_2_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_7VAB_L_L_2_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/AIB/AIB_7VAB_L_L_13.png)
A 2D representation of the interactions of AIB in 7VAB colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:K16 | R:R:F127 | 9.93 | 0 | No | No | 0 | 2 | 1 | 2 | L:L:L14 | R:R:R131 | 2.43 | 0 | No | No | 0 | 3 | 1 | 2 | L:L:I17 | R:R:R131 | 2.51 | 0 | No | No | 0 | 3 | 1 | 2 | L:L:?13 | L:L:I12 | 2.73 | 0 | Yes | No | 0 | 0 | 0 | 1 | L:L:?13 | L:L:L14 | 2.65 | 0 | Yes | No | 0 | 0 | 0 | 1 | L:L:?13 | L:L:K16 | 5.4 | 0 | Yes | No | 0 | 0 | 0 | 1 | L:L:?13 | L:L:I17 | 4.1 | 0 | Yes | No | 0 | 0 | 0 | 1 | L:L:L14 | R:R:P197 | 1.64 | 0 | No | No | 0 | 4 | 1 | 2 | L:L:I17 | L:L:K20 | 1.45 | 0 | No | No | 0 | 0 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 4.00 | Average Number Of Links With An Hub | 0.00 | Average Interaction Strength | 3.72 | Average Nodes In Shell | 9.00 | Average Hubs In Shell | 1.00 | Average Links In Shell | 9.00 | Average Links Mediated by Hubs In Shell | 4.00 |
| ![](/psngpcr/ligands/AIB/AIB_7VAB_L_L_13_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_7VAB_L_L_13_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7VBH | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Peptide-20 | - | Gs/Beta1/Gamma2 | 3 | 2022-04-06 | 10.1038/s41467-022-28683-0 |
![](/psngpcr/ligands/AIB/AIB_7VBH_L_L_2.png)
A 2D representation of the interactions of AIB in 7VBH colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?2 | L:L:H1 | 6.16 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:G4 | L:L:H1 | 4.77 | 2 | No | Yes | 0 | 0 | 2 | 1 | L:L:H1 | R:R:Q234 | 11.13 | 2 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:H1 | R:R:W306 | 22.22 | 2 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:?2 | L:L:Q3 | 3.82 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?2 | L:L:T5 | 15.53 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?2 | R:R:L384 | 5.3 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?2 | R:R:L388 | 5.3 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:F6 | L:L:Q3 | 3.51 | 2 | No | Yes | 0 | 0 | 2 | 1 | L:L:Q3 | R:R:Y148 | 14.65 | 2 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:Q3 | R:R:Y152 | 3.38 | 2 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:Q3 | R:R:V194 | 5.73 | 2 | Yes | No | 0 | 7 | 1 | 2 | L:L:Q3 | R:R:K197 | 10.85 | 2 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:Q3 | R:R:L388 | 5.32 | 2 | Yes | Yes | 0 | 7 | 1 | 1 | L:L:G4 | R:R:W306 | 5.63 | 2 | No | Yes | 0 | 6 | 2 | 2 | L:L:T5 | R:R:D372 | 7.23 | 2 | Yes | Yes | 0 | 5 | 1 | 2 | L:L:T5 | R:R:R380 | 7.76 | 2 | Yes | Yes | 0 | 5 | 1 | 2 | L:L:T5 | R:R:L384 | 7.37 | 2 | Yes | Yes | 0 | 5 | 1 | 1 | L:L:F6 | R:R:Y148 | 10.32 | 2 | No | Yes | 0 | 7 | 2 | 2 | R:R:L144 | R:R:L384 | 5.54 | 2 | No | Yes | 6 | 5 | 2 | 1 | R:R:L144 | R:R:L388 | 5.54 | 2 | No | Yes | 6 | 7 | 2 | 1 | R:R:Y148 | R:R:Y152 | 4.96 | 2 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:K197 | R:R:Y148 | 3.58 | 2 | Yes | Yes | 6 | 7 | 2 | 2 | R:R:L388 | R:R:Y148 | 9.38 | 2 | Yes | Yes | 7 | 7 | 1 | 2 | R:R:V194 | R:R:Y152 | 11.36 | 2 | No | Yes | 7 | 7 | 2 | 2 | R:R:Q234 | R:R:W306 | 4.38 | 2 | Yes | Yes | 7 | 6 | 2 | 2 | R:R:D372 | R:R:W306 | 6.7 | 2 | Yes | Yes | 5 | 6 | 2 | 2 | R:R:D372 | R:R:R380 | 5.96 | 2 | Yes | Yes | 5 | 5 | 2 | 2 | R:R:L384 | R:R:L388 | 4.15 | 2 | Yes | Yes | 5 | 7 | 1 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 5.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 7.22 | Average Nodes In Shell | 17.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 29.00 | Average Links Mediated by Hubs In Shell | 29.00 |
| ![](/psngpcr/ligands/AIB/AIB_7VBH_L_L_2_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_7VBH_L_L_2_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7VBI | B1 | Peptide | Glucagon | GLP-1 | Homo sapiens | Non-Acylated Tirzepatide | - | Gs/Beta1/Gamma2 | 3 | 2022-03-02 | 10.1038/s41467-022-28683-0 |
![](/psngpcr/ligands/AIB/AIB_7VBI_L_L_2.png)
A 2D representation of the interactions of AIB in 7VBI colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?2 | L:L:Y1 | 6.74 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:E3 | L:L:Y1 | 3.37 | 1 | Yes | Yes | 0 | 0 | 1 | 1 | L:L:G4 | L:L:Y1 | 5.79 | 1 | No | Yes | 0 | 0 | 1 | 1 | L:L:Y1 | R:R:Q234 | 11.27 | 1 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:Y1 | R:R:V237 | 8.83 | 1 | Yes | No | 0 | 6 | 1 | 2 | L:L:Y1 | R:R:W306 | 5.79 | 1 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:?2 | L:L:E3 | 11.42 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?2 | L:L:G4 | 3.28 | 1 | Yes | No | 0 | 0 | 0 | 1 | L:L:?2 | L:L:T5 | 4.24 | 1 | Yes | No | 0 | 0 | 0 | 1 | L:L:?2 | R:R:E387 | 6.35 | 1 | Yes | No | 0 | 8 | 0 | 1 | L:L:?2 | R:R:L388 | 3.98 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:E3 | R:R:Y152 | 8.98 | 1 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:E3 | R:R:R190 | 8.14 | 1 | Yes | Yes | 0 | 8 | 1 | 2 | L:L:E3 | R:R:L388 | 3.98 | 1 | Yes | Yes | 0 | 7 | 1 | 1 | L:L:T5 | R:R:W306 | 4.85 | 1 | No | Yes | 0 | 6 | 1 | 2 | L:L:T5 | R:R:D372 | 14.45 | 1 | No | Yes | 0 | 5 | 1 | 2 | L:L:F6 | R:R:Y148 | 8.25 | 1 | Yes | Yes | 0 | 7 | 2 | 2 | L:L:F6 | R:R:L388 | 3.65 | 1 | Yes | Yes | 0 | 7 | 2 | 1 | R:R:Y148 | R:R:Y152 | 4.96 | 1 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:L388 | R:R:Y148 | 3.52 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | R:R:R190 | R:R:Y152 | 7.2 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | R:R:R190 | R:R:V237 | 10.46 | 1 | Yes | No | 8 | 6 | 2 | 2 | R:R:D372 | R:R:W306 | 5.58 | 1 | Yes | Yes | 5 | 6 | 2 | 2 | R:R:F367 | R:R:T386 | 10.38 | 1 | Yes | No | 7 | 4 | 2 | 2 | R:R:E387 | R:R:F367 | 5.83 | 1 | No | Yes | 8 | 7 | 1 | 2 | R:R:E387 | R:R:T386 | 5.64 | 1 | No | No | 8 | 4 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 6.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 6.00 | Average Nodes In Shell | 17.00 | Average Hubs In Shell | 12.00 | Average Links In Shell | 26.00 | Average Links Mediated by Hubs In Shell | 25.00 |
| ![](/psngpcr/ligands/AIB/AIB_7VBI_L_L_2_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_7VBI_L_L_2_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/AIB/AIB_7VBI_L_L_13.png)
A 2D representation of the interactions of AIB in 7VBI colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:L14 | L:L:Y10 | 12.89 | 0 | No | No | 0 | 0 | 1 | 2 | L:L:?13 | L:L:L14 | 5.3 | 0 | No | No | 0 | 0 | 0 | 1 | L:L:?13 | L:L:K16 | 5.4 | 0 | No | No | 0 | 0 | 0 | 1 | L:L:?13 | L:L:I17 | 6.84 | 0 | No | No | 0 | 0 | 0 | 1 | L:L:L14 | R:R:Y205 | 8.21 | 0 | No | Yes | 0 | 3 | 1 | 2 | L:L:K16 | L:L:K20 | 7.18 | 0 | No | No | 0 | 0 | 1 | 2 | L:L:K16 | R:R:W91 | 3.48 | 0 | No | Yes | 0 | 4 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 3.00 | Average Number Of Links With An Hub | 0.00 | Average Interaction Strength | 5.85 | Average Nodes In Shell | 8.00 | Average Hubs In Shell | 2.00 | Average Links In Shell | 7.00 | Average Links Mediated by Hubs In Shell | 2.00 |
| ![](/psngpcr/ligands/AIB/AIB_7VBI_L_L_13_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_7VBI_L_L_13_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7Y35 | B1 | Peptide | Parathyroid hormone | PTH1 | Homo sapiens | Abaloparatide | - | Gs/Beta1/Gamma2 | 2.9 | 2023-07-05 | To be published |
![](/psngpcr/ligands/AIB/AIB_7Y35_L_L_29.png)
A 2D representation of the interactions of AIB in 7Y35 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?29 | L:L:K30 | 4.05 | 4 | Yes | No | 0 | 0 | 0 | 1 | L:L:?29 | L:L:T33 | 8.47 | 4 | Yes | No | 0 | 0 | 0 | 1 | L:L:?29 | L:L:?34 | 9.91 | 4 | Yes | No | 0 | 0 | 0 | 1 | L:L:H32 | L:L:T33 | 2.74 | 4 | Yes | No | 0 | 0 | 2 | 1 | L:L:?34 | L:L:T33 | 11.02 | 4 | No | No | 0 | 0 | 1 | 1 | L:L:?29 | L:L:E25 | 1.27 | 4 | Yes | No | 0 | 0 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 4.00 | Average Number Of Links With An Hub | 0.00 | Average Interaction Strength | 5.92 | Average Nodes In Shell | 6.00 | Average Hubs In Shell | 2.00 | Average Links In Shell | 6.00 | Average Links Mediated by Hubs In Shell | 5.00 |
| ![](/psngpcr/ligands/AIB/AIB_7Y35_L_L_29_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_7Y35_L_L_29_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8FLS | B1 | Peptide | Parathyroid hormone | PTH1 | Homo Sapiens | Abaloparatide | - | Gs/Beta1/Gamma2 | 3.09 | 2023-04-26 | 10.1016/j.str.2023.04.002 |
![](/psngpcr/ligands/AIB/AIB_8FLS_L_L_29.png)
A 2D representation of the interactions of AIB in 8FLS colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:L28 | R:R:Y167 | 3.52 | 0 | No | Yes | 0 | 5 | 1 | 2 | L:L:?29 | L:L:K30 | 4.05 | 0 | No | No | 0 | 0 | 0 | 1 | L:L:?29 | R:R:R162 | 4.65 | 0 | No | No | 0 | 3 | 0 | 1 | L:L:L28 | R:R:V171 | 2.98 | 0 | No | No | 0 | 3 | 1 | 2 | L:L:?29 | L:L:L28 | 2.65 | 0 | No | No | 0 | 0 | 0 | 1 | L:L:K26 | L:L:K30 | 1.44 | 0 | No | No | 0 | 0 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 3.00 | Average Number Of Links With An Hub | 0.00 | Average Interaction Strength | 3.78 | Average Nodes In Shell | 7.00 | Average Hubs In Shell | 1.00 | Average Links In Shell | 6.00 | Average Links Mediated by Hubs In Shell | 1.00 |
| ![](/psngpcr/ligands/AIB/AIB_8FLS_L_L_29_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_8FLS_L_L_29_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8FLT | B1 | Peptide | Parathyroid hormone | PTH1 | Homo Sapiens | M-PTH(1-14) | - | Gs/Beta1/Gamma2 | 3.03 | 2023-04-26 | 10.1016/j.str.2023.04.002 |
![](/psngpcr/ligands/AIB/AIB_8FLT_L_L_1.png)
A 2D representation of the interactions of AIB in 8FLT colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?1 | L:L:V2 | 5.71 | 1 | Yes | No | 0 | 0 | 0 | 1 | L:L:?1 | L:L:Q6 | 3.82 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?1 | R:R:W361 | 3.27 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:?1 | R:R:Q364 | 5.1 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:L368 | 6.63 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:I5 | L:L:V2 | 9.22 | 1 | No | No | 0 | 0 | 2 | 1 | L:L:V2 | R:R:Q364 | 8.6 | 1 | No | Yes | 0 | 7 | 1 | 1 | L:L:I5 | R:R:Q364 | 13.72 | 1 | No | Yes | 0 | 7 | 2 | 1 | L:L:Q10 | L:L:Q6 | 7.68 | 1 | Yes | Yes | 0 | 0 | 2 | 1 | L:L:Q6 | R:R:Y429 | 19.16 | 1 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:Q6 | R:R:Q440 | 5.12 | 1 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:Q6 | R:R:M441 | 6.8 | 1 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:Q10 | R:R:Y429 | 4.51 | 1 | Yes | Yes | 0 | 6 | 2 | 2 | R:R:N358 | R:R:W361 | 4.52 | 0 | No | Yes | 4 | 8 | 2 | 1 | R:R:K360 | R:R:W361 | 6.96 | 1 | Yes | Yes | 7 | 8 | 2 | 1 | R:R:K360 | R:R:Q364 | 4.07 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:K360 | R:R:Y429 | 16.72 | 1 | Yes | Yes | 7 | 6 | 2 | 2 | R:R:Q364 | R:R:W361 | 7.67 | 1 | Yes | Yes | 7 | 8 | 1 | 1 | R:R:V365 | R:R:W361 | 6.13 | 0 | No | Yes | 5 | 8 | 2 | 1 | R:R:Q364 | R:R:Y429 | 10.15 | 1 | Yes | Yes | 7 | 6 | 1 | 2 | R:R:M441 | R:R:Q440 | 4.08 | 1 | Yes | Yes | 6 | 6 | 2 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 5.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 4.91 | Average Nodes In Shell | 14.00 | Average Hubs In Shell | 9.00 | Average Links In Shell | 21.00 | Average Links Mediated by Hubs In Shell | 20.00 |
| ![](/psngpcr/ligands/AIB/AIB_8FLT_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_8FLT_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/AIB/AIB_8FLT_L_L_3.png)
A 2D representation of the interactions of AIB in 8FLT colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?3 | L:L:E4 | 5.08 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?3 | R:R:M441 | 4.06 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?3 | R:R:E444 | 16.5 | 1 | Yes | No | 0 | 7 | 0 | 1 | L:L:?3 | R:R:M445 | 5.42 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:E4 | R:R:Y195 | 4.49 | 1 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:E4 | R:R:R233 | 6.98 | 1 | Yes | Yes | 0 | 8 | 1 | 2 | L:L:E4 | R:R:I237 | 4.1 | 1 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:E4 | R:R:L292 | 5.3 | 1 | Yes | No | 0 | 6 | 1 | 2 | L:L:E4 | R:R:M445 | 8.12 | 1 | Yes | Yes | 0 | 6 | 1 | 1 | L:L:E4 | R:R:N448 | 6.57 | 1 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:Q6 | R:R:Q440 | 5.12 | 1 | Yes | Yes | 0 | 6 | 2 | 2 | L:L:Q6 | R:R:M441 | 6.8 | 1 | Yes | Yes | 0 | 6 | 2 | 1 | L:L:L7 | R:R:M445 | 4.24 | 0 | No | Yes | 0 | 6 | 2 | 1 | R:R:L187 | R:R:M441 | 4.24 | 0 | No | Yes | 5 | 6 | 2 | 1 | R:R:Y191 | R:R:Y195 | 5.96 | 0 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:M445 | R:R:Y191 | 8.38 | 1 | Yes | Yes | 6 | 7 | 1 | 2 | R:R:R233 | R:R:Y195 | 11.32 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | R:R:I237 | R:R:Y195 | 8.46 | 1 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:L292 | R:R:R233 | 7.29 | 1 | No | Yes | 6 | 8 | 2 | 2 | R:R:N448 | R:R:R233 | 6.03 | 1 | Yes | Yes | 6 | 8 | 2 | 2 | R:R:F424 | R:R:Q440 | 9.37 | 1 | Yes | Yes | 7 | 6 | 2 | 2 | R:R:E444 | R:R:F424 | 7 | 1 | No | Yes | 7 | 7 | 1 | 2 | R:R:M441 | R:R:W437 | 22.1 | 1 | Yes | Yes | 6 | 5 | 1 | 2 | R:R:M441 | R:R:Q440 | 4.08 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | R:R:E444 | R:R:Q440 | 5.1 | 1 | No | Yes | 7 | 6 | 1 | 2 | R:R:I190 | R:R:M445 | 2.92 | 0 | No | Yes | 6 | 6 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 4.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 7.77 | Average Nodes In Shell | 18.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 26.00 | Average Links Mediated by Hubs In Shell | 26.00 |
| ![](/psngpcr/ligands/AIB/AIB_8FLT_L_L_3_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/AIB/AIB_8FLT_L_L_3_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|