Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1B:B:E10 5.045408
2B:B:I18 3.32407
3B:B:I37 4.3875452
4B:B:V40 3.325453
5B:B:R52 10.2225407
6B:B:H54 8.131676109
7B:B:K57 11.185409
8B:B:W63 6.0656117
9B:B:V71 4.055408
10B:B:Q75 7.6409
11B:B:D76 6.445409
12B:B:K78 3.785408
13B:B:L79 5.3875407
14B:B:W82 10.5156109
15B:B:K89 6.82754109
16B:B:I93 8.315407
17B:B:L95 4.068508
18B:B:W99 8.2725199
19B:B:Y105 4.445606
20B:B:N110 6.55254244
21B:B:Y124 7.075406
22B:B:H142 8.145689
23B:B:Y145 5.0856148
24B:B:L146 4.575487
25B:B:F151 5.5775409
26B:B:L152 5.895403
27B:B:T159 6.06589
28B:B:S160 4.39466
29B:B:C166 4.0475468
30B:B:W169 8.55333688
31B:B:Q176 7.0525484
32B:B:F180 5.922567
33B:B:H183 7.624569
34B:B:D186 5.92754149
35B:B:V187 4.685469
36B:B:F199 6.815469
37B:B:S201 5.2625469
38B:B:K209 8.98466
39B:B:L210 3.76405
40B:B:W211 8.26667668
41B:B:F222 7.242528
42B:B:H225 7.82333629
43B:B:I232 4.22628
44B:B:F234 8.6225405
45B:B:F235 6.346676176
46B:B:P236 4.5854177
47B:B:F241 7.4175426
48B:B:D247 7.7325429
49B:B:R251 7.82833628
50B:B:F253 6.06571726
51B:B:R256 5.425409
52B:B:D258 7.9725427
53B:B:Q259 3.5375406
54B:B:Y264 4.89833605
55B:B:I269 4.1925404
56B:B:F278 4.3765177
57B:B:R283 7.15559
58B:B:Y289 5.85833647
59B:B:D290 5.38833646
60B:B:V296 4.2725405
61B:B:K301 7.38405
62B:B:R304 6.5975445
63B:B:H311 5.6945169
64B:B:R314 8.772548
65B:B:L318 3.84506
66B:B:D323 6.734117
67B:B:M325 5.295405
68B:B:W332 10.146549
69B:B:L336 4.064107
70B:B:W339 6.3125169
71A:A:K24 4.17254284
72A:A:H41 5.1554296
73A:A:S51 3.3025319
74A:A:I56 3.6225408
75A:A:F219 5.655298
76A:A:F222 6.436196
77A:A:D223 5.66409
78A:A:Q227 5.674149
79A:A:K233 7.24409
80A:A:W234 5.52833609
81A:A:F238 7.1256199
82A:A:I244 4.38408
83A:A:I245 3.644308
84A:A:F246 4.6325409
85A:A:V248 3.7925407
86A:A:F273 5.315679
87A:A:I276 2408
88A:A:W277 6.44143776
89A:A:W281 7.448545
90A:A:I288 3.2845309
91A:A:L291 4.44599
92A:A:Q294 6.07496
93A:A:L296 5.5125407
94A:A:F312 5.13254208
95A:A:E314 6.0025205
96A:A:F315 9.752506
97A:A:Y318 8.6425407
98A:A:P321 6.4175404
99A:A:E330 4.894333
100A:A:D331 3.654334
101A:A:V334 3.02754334
102A:A:F340 10.0625206
103A:A:R342 6.362595
104A:A:F345 5.668578
105A:A:I348 6.31475
106A:A:S349 3.985408
107A:A:G353 3.925472
108A:A:F363 7.095495
109A:A:R385 6.664126
110A:A:L388 4.4845128
111A:A:L393 5.32754129
112R:R:W39 8.955415
113R:R:Y42 6.788516
114R:R:P55 4.57754361
115R:R:Y69 5.76667616
116R:R:W72 7.344519
117R:R:Y88 7.645615
118R:R:W91 11.9625404
119R:R:R102 8.438518
120R:R:F103 12.36754384
121R:R:W110 7.88167619
122R:R:R121 6.07416
123R:R:Y145 4.1975405
124R:R:Y152 4.95537
125R:R:L159 4.0865399
126R:R:F187 7.9408
127R:R:R190 6.43667638
128R:R:W214 9.455611
129R:R:F230 5.175405
130R:R:M233 6.9325436
131R:R:Y242 6.1925186
132R:R:W243 11.1345219
133R:R:Y269 5.27407
134R:R:W274 8.0456219
135R:R:P277 4.5685189
136R:R:F280 7.044185
137R:R:W284 7.9185138
138R:R:Y291 5.35254133
139R:R:E292 6.35136
140R:R:W297 10.4165138
141R:R:R299 4.738504
142R:R:Y305 9.08754134
143R:R:W306 5.612506
144R:R:R310 4.52754416
145R:R:K334 3.945717129
146R:R:L349 3.62409
147R:R:L356 4.6775409
148R:R:L360 3.185409
149R:R:H363 9.2975438
150R:R:E364 8.9475438
151R:R:F367 8.5854427
152R:R:M371 4.5454417
153R:R:E373 6.15754414
154R:R:F381 4.565404
155R:R:T391 4.3825436
156R:R:Q394 6.9475439
157R:R:L401 3.1775408
158R:R:Y402 7.18408
159R:R:C403 3.8375409
160R:R:F404 2.895408
161G:G:Y40 9.92754176
162G:G:D48 6.47167659
163G:G:L51 4.354556
164G:G:P60 6.6954239
165G:G:F61 5.0365238
166L:L:?2 4.725400
167L:L:E3 5.27667630
168L:L:F6 6.8425150
169L:L:Y10 6.71754150
170L:L:F22 6.5875410
171L:L:L26 5.6575410
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:F199 B:B:L190 10.71894.87YesNo095
2B:B:C148 B:B:L190 11.97853.17NoNo065
3B:B:C148 B:B:R150 12.34175.57NoNo066
4B:B:H62 B:B:R150 12.432411.28NoNo066
5B:B:H62 B:B:Y105 12.52393.27NoYes066
6B:B:V71 B:B:Y105 13.05515.05YesYes086
7B:B:L79 B:B:V71 13.51662.98YesYes078
8B:B:I93 B:B:L79 20.88848.56YesYes077
9B:B:I93 B:B:P94 36.36043.39YesNo075
10B:B:K78 B:B:P94 36.43055.02YesNo085
11B:B:D76 B:B:K78 14.40075.53YesYes098
12B:B:D76 B:B:L55 18.94156.79YesNo096
13A:A:Y37 B:B:L55 16.44225.86NoNo036
14A:A:R42 A:A:Y37 14.514912.35NoNo093
15A:A:F222 A:A:R42 14.33714.28YesNo069
16A:A:F222 B:B:W99 11.487817.04YesYes1969
17B:B:Q75 B:B:W99 26.78673.29YesYes099
18B:B:K57 B:B:Q75 27.355317.63YesYes099
19B:B:K57 B:B:W332 54.462717.4YesYes099
20B:B:R314 B:B:W332 27.857812YesYes489
21B:B:D290 B:B:R314 27.79695.96YesYes468
22B:B:C271 B:B:D290 73.44396.22NoYes456
23B:B:C271 B:B:Y289 73.1034.03NoYes457
24B:B:W297 B:B:Y289 71.91963.86NoYes087
25B:B:W297 B:B:Y264 72.74984.82NoYes085
26A:A:D240 B:B:W99 26.61035.58NoYes079
27A:A:D240 B:B:K57 26.80786.91NoYes079
28A:A:W281 B:B:W332 27.85783.75YesYes459
29A:A:W281 B:B:D290 27.79696.7YesYes456
30G:G:D48 G:G:P49 32.35284.83YesNo097
31B:B:M325 G:G:P49 31.95426.71YesNo057
32B:B:M325 G:G:P60 31.4073.35YesYes059
33B:B:Y85 G:G:P60 31.437211.13NoYes2349
34B:B:R68 B:B:Y85 32.388219.55NoNo054
35B:B:D83 B:B:R68 32.400414.29NoNo085
36B:B:D83 B:B:T86 32.41567.23NoNo086
37B:B:N88 B:B:T86 32.432910.24NoNo076
38A:A:Q19 B:B:N88 32.45263.96NoNo047
39A:A:N23 A:A:Q19 32.54276.6NoNo074
40A:A:N23 B:B:K89 32.85536.99NoYes079
41A:A:I26 B:B:K89 27.16714.36NoYes099
42A:A:I26 B:B:A92 27.15484.87NoNo096
43B:B:A92 B:B:K78 27.14383.21NoYes068
44B:B:M45 G:G:L50 1002.83NoNo049
45G:G:D48 G:G:L50 99.94384.07YesNo599
46B:B:M45 B:B:W339 99.25284.65NoYes049
47B:B:H311 B:B:W339 98.225.29YesYes1699
48B:B:H311 B:B:S331 99.04082.79YesNo099
49B:B:D333 B:B:S331 98.97938.83NoNo099
50B:B:D333 B:B:F335 97.913815.52NoNo094
51B:B:F335 B:B:R52 97.8511.76NoYes047
52B:B:R52 R:R:R170 97.593315.99YesNo078
53A:A:W234 B:B:Y145 16.14393.86YesYes098
54B:B:I93 B:B:Y124 15.352612.09YesYes076
55B:B:C114 B:B:L95 14.31773.17NoYes088
56B:B:F151 B:B:I157 12.934310.05YesNo097
57B:B:F151 B:B:I123 10.08533.77YesNo096
58B:B:C121 B:B:G115 20.49081.96NoNo089
59B:B:C114 B:B:G115 21.07191.96NoNo089
60A:A:K233 B:B:Y145 17.25283.58YesYes098
61A:A:K233 B:B:D228 17.506411.06YesNo099
62B:B:D228 B:B:D246 17.59275.32NoNo099
63B:B:F235 B:B:F278 36.68858.57YesYes1767
64B:B:F278 B:B:L285 73.14044.87YesNo076
65B:B:L285 B:B:Y264 73.16073.52NoYes065
66B:B:F278 B:B:P236 36.40062.89YesYes1777
67B:B:K280 G:G:D48 72.67678.3NoYes019
68B:B:K280 G:G:E47 72.64835.4NoNo013
69G:G:E47 G:G:H44 72.63924.92NoNo036
70G:G:H44 G:G:Y40 72.633413.07NoYes066
71B:B:D246 B:B:G272 17.67993.35NoNo094
72B:B:D290 B:B:G272 17.89155.03YesNo064
73A:A:I245 A:A:I288 14.24945.89YesYes3089
74A:A:D378 A:A:Y360 16.216919.54NoNo078
75A:A:D381 A:A:Y360 24.308610.34NoNo088
76A:A:D381 R:R:K334 24.42568.3NoYes1289
77A:A:L388 R:R:K334 25.68482.82YesYes1289
78A:A:L388 A:A:L393 26.31215.54YesYes1289
79A:A:L393 R:R:L356 28.31448.3YesYes099
80R:R:L356 R:R:Y402 28.17564.69YesYes098
81R:R:H180 R:R:Y402 30.6137.62NoYes098
82R:R:E247 R:R:H180 30.75639.85NoNo099
83R:R:E247 R:R:I179 34.11644.1NoNo098
84R:R:I179 R:R:T175 97.1393.04NoNo087
85R:R:F266 R:R:T175 97.20433.89NoNo067
86R:R:F266 R:R:Y178 97.39943.09NoNo066
87R:R:H173 R:R:Y178 97.46427.62NoNo076
88R:R:H173 R:R:R170 97.528810.16NoNo078
89A:A:F238 A:A:L44 22.454917.05YesNo099
90A:A:I244 A:A:L44 21.92358.56YesNo089
91A:A:I244 A:A:V241 21.92353.07YesNo089
92A:A:F238 A:A:V241 22.45493.93YesNo099
93A:A:I244 A:A:L46 41.70962.85YesNo089
94A:A:F246 A:A:L46 40.64097.31YesNo099
95A:A:I235 A:A:W234 17.48283.52NoYes099
96A:A:L291 A:A:V248 38.41562.98YesYes097
97A:A:F246 A:A:V248 42.79162.62YesYes097
98A:A:F273 A:A:I276 12.14792.51YesYes098
99A:A:I276 A:A:L282 17.00311.43YesNo089
100A:A:I235 A:A:L282 17.32281.43NoNo099
101A:A:F363 A:A:L291 31.22354.87YesYes959
102A:A:E330 A:A:T335 14.6165.64YesNo034
103A:A:P326 A:A:T335 15.94395.25NoNo014
104A:A:P326 A:A:Y339 18.59942.78NoNo013
105A:A:R342 A:A:Y339 23.8925.14YesNo053
106A:A:F363 A:A:R342 28.84514.28YesYes955
107R:R:I179 R:R:Y250 77.00948.46NoNo088
108R:R:Y250 R:R:Y269 76.53515.96NoYes087
109R:R:V246 R:R:Y269 75.77626.31NoYes087
110R:R:V246 R:R:W243 75.39528.58NoYes089
111R:R:S186 R:R:W243 39.67464.94NoYes2199
112R:R:N240 R:R:S186 39.71995.96NoNo099
113R:R:N240 R:R:R190 37.11819.64NoYes098
114L:L:E3 R:R:R190 35.09029.3YesYes308
115L:L:E3 R:R:M233 28.13414.06YesYes306
116R:R:K197 R:R:M233 54.977912.96NoYes066
117R:R:F230 R:R:K197 55.29576.2YesNo056
118R:R:F230 R:R:T298 47.46237.78YesNo055
119L:L:S11 R:R:T298 47.18996.4NoNo005
120L:L:S11 R:R:R299 46.92013.95NoYes004
121L:L:D15 R:R:R299 44.77163.57NoYes004
122L:L:D15 L:L:K16 44.49656.91NoNo000
123R:R:W243 R:R:W274 35.274718.74YesYes2199
124R:R:L189 R:R:W274 27.45517.97NoYes079
125R:R:C236 R:R:L189 27.33014.76NoNo057
126R:R:C236 R:R:S193 26.7976.89NoNo356
127R:R:M233 R:R:S193 26.77767.67YesNo366
128L:L:K16 L:L:Q19 43.9469.49NoNo000
129L:L:Q19 R:R:T35 24.25787.09NoNo005
130R:R:K38 R:R:T35 23.9783NoNo045
131R:R:K38 R:R:Y88 22.85373.58NoYes045
132R:R:Y69 R:R:Y88 17.44473.97YesYes165
133R:R:R121 R:R:Y69 20.19435.14YesYes166
134R:R:R102 R:R:R121 19.62953.2YesYes186
135R:R:R102 R:R:W72 17.9113.99YesYes189
136R:R:W110 R:R:W72 16.18327.5YesYes199
137R:R:C62 R:R:W110 10.42446.53NoYes199
138L:L:Q19 R:R:P90 19.42097.9NoNo004
139R:R:P90 R:R:W91 19.138810.81NoYes044
140R:R:L89 R:R:W91 17.74085.69NoYes054
141R:R:L89 R:R:Y69 17.18239.38NoYes056
142B:B:F235 G:G:Y40 36.36996.19YesYes1766
143B:B:P236 G:G:Y40 36.24134.17YesYes1776
144A:A:F238 B:B:W99 40.97512.03YesYes1999
145B:B:C121 B:B:L146 11.25673.17NoYes087
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:K16 R:R:V30 6.07 0 No No 0 2 0 1
R:R:R299 R:R:S31 7.91 0 Yes No 4 4 1 2
R:R:L32 R:R:Q213 6.65 1 No No 4 4 1 2
R:R:L32 R:R:W214 3.42 1 No Yes 4 1 1 1
L:L:F22 R:R:L32 3.65 1 Yes No 0 4 0 1
R:R:K38 R:R:T35 3 0 No No 4 5 2 1
L:L:Q19 R:R:T35 7.09 0 No No 0 5 0 1
R:R:K38 R:R:Y88 3.58 0 No Yes 4 5 2 1
R:R:R43 R:R:W39 9 0 No Yes 4 5 2 1
R:R:W39 R:R:Y88 16.4 1 Yes Yes 5 5 1 1
L:L:L26 R:R:W39 7.97 1 Yes Yes 0 5 0 1
R:R:P86 R:R:Y42 9.74 1 No Yes 8 6 2 2
R:R:Y42 R:R:Y88 7.94 1 Yes Yes 6 5 2 1
L:L:L26 R:R:E68 3.98 1 Yes No 0 4 0 1
L:L:G29 R:R:E68 4.91 0 No No 0 4 0 1
R:R:C85 R:R:Y69 5.38 0 No Yes 9 6 2 1
R:R:Y69 R:R:Y88 3.97 1 Yes Yes 6 5 1 1
R:R:L89 R:R:Y69 9.38 0 No Yes 5 6 2 1
R:R:R121 R:R:Y69 5.14 1 Yes Yes 6 6 1 1
R:R:L123 R:R:Y69 4.69 1 No Yes 5 6 2 1
L:L:I27 R:R:Y69 6.04 1 No Yes 0 6 0 1
R:R:P86 R:R:Y88 6.95 1 No Yes 8 5 2 1
L:L:L26 R:R:Y88 7.03 1 Yes Yes 0 5 0 1
R:R:L89 R:R:W91 5.69 0 No Yes 5 4 2 1
R:R:P90 R:R:W91 10.81 0 No Yes 4 4 1 1
L:L:Q19 R:R:P90 7.9 0 No No 0 4 0 1
R:R:E128 R:R:W91 23.99 0 No Yes 3 4 1 1
L:L:V23 R:R:W91 7.36 0 No Yes 0 4 0 1
R:R:R102 R:R:R121 3.2 1 Yes Yes 8 6 2 1
R:R:L123 R:R:R121 10.93 1 No Yes 5 6 2 1
L:L:I27 R:R:R121 5.01 1 No Yes 0 6 0 1
R:R:E127 R:R:E128 15.22 0 No No 2 3 2 1
L:L:K20 R:R:E128 4.05 0 No No 0 3 0 1
L:L:F6 R:R:L141 3.65 15 Yes No 0 5 0 1
L:L:Y10 R:R:L141 9.38 15 Yes No 0 5 0 1
R:R:Y145 R:R:Y148 3.97 0 Yes No 5 7 2 1
L:L:F6 R:R:Y148 10.32 15 Yes No 0 7 0 1
R:R:R190 R:R:Y152 5.14 3 Yes Yes 8 7 1 1
R:R:V194 R:R:Y152 8.83 3 No Yes 7 7 1 1
R:R:T391 R:R:Y152 3.75 3 Yes Yes 6 7 2 1
L:L:E3 R:R:Y152 4.49 3 Yes Yes 0 7 0 1
R:R:R190 R:R:V237 6.54 3 Yes No 8 6 1 1
R:R:N240 R:R:R190 9.64 0 No Yes 9 8 2 1
R:R:R190 R:R:Y241 4.12 3 Yes No 8 8 1 2
R:R:R190 R:R:T391 3.88 3 Yes Yes 8 6 1 2
L:L:E3 R:R:R190 9.3 3 Yes Yes 0 8 0 1
R:R:M233 R:R:S193 7.67 3 Yes No 6 6 1 2
R:R:M233 R:R:V194 3.04 3 Yes No 6 7 1 1
L:L:E3 R:R:V194 4.28 3 Yes No 0 7 0 1
R:R:F230 R:R:K197 6.2 0 Yes No 5 6 2 1
R:R:K197 R:R:M233 12.96 0 No Yes 6 6 1 1
L:L:T7 R:R:K197 6.01 0 No No 0 6 0 1
L:L:Y10 R:R:L201 3.52 15 Yes No 0 7 0 1
R:R:M204 R:R:Y205 13.17 0 No No 3 3 2 1
L:L:L14 R:R:Y205 5.86 0 No No 0 3 0 1
R:R:Q210 R:R:T207 2.83 0 No No 4 3 1 2
R:R:Q210 R:R:W214 12.05 0 No Yes 4 1 1 1
L:L:A18 R:R:Q210 4.55 0 No No 0 4 0 1
R:R:Q211 R:R:W214 9.86 1 No Yes 4 1 1 1
L:L:W25 R:R:Q211 3.29 1 No No 0 4 0 1
L:L:F22 R:R:W214 16.04 1 Yes Yes 0 1 0 1
L:L:W25 R:R:W214 14.06 1 No Yes 0 1 0 1
R:R:F230 R:R:T298 7.78 0 Yes No 5 5 2 1
L:L:E3 R:R:M233 4.06 3 Yes Yes 0 6 0 1
R:R:Q234 R:R:W284 5.48 0 No Yes 7 8 1 2
L:L:Y1 R:R:Q234 13.53 0 No No 0 7 0 1
L:L:Y1 R:R:V237 10.09 0 No No 0 6 0 1
L:L:E3 R:R:V237 5.7 3 Yes No 0 6 0 1
R:R:I309 R:R:W284 11.74 0 No Yes 7 8 2 2
R:R:G295 R:R:R299 4.5 0 No Yes 4 4 2 1
L:L:S11 R:R:T298 6.4 0 No No 0 5 0 1
L:L:S11 R:R:R299 3.95 0 No Yes 0 4 0 1
L:L:I12 R:R:R299 3.76 0 No Yes 0 4 0 1
L:L:D15 R:R:R299 3.57 0 No Yes 0 4 0 1
R:R:N300 R:R:W306 11.3 0 No Yes 6 6 1 1
L:L:S8 R:R:N300 4.47 0 No No 0 6 0 1
R:R:I309 R:R:W306 3.52 0 No Yes 7 6 2 1
R:R:D372 R:R:W306 5.58 0 No Yes 5 6 2 1
L:L:G4 R:R:W306 2.81 0 No Yes 0 6 0 1
L:L:T5 R:R:W306 4.85 0 No Yes 0 6 0 1
R:R:F367 R:R:T386 6.49 42 Yes No 7 4 2 2
R:R:E387 R:R:F367 11.66 42 No Yes 8 7 1 2
R:R:L384 R:R:R380 3.64 15 No No 5 5 1 1
L:L:D9 R:R:R380 4.76 15 No No 0 5 0 1
L:L:F6 R:R:L384 6.09 15 Yes No 0 5 0 1
L:L:D9 R:R:L384 5.43 15 No No 0 5 0 1
R:R:E387 R:R:T386 5.64 42 No No 8 4 1 2
L:L:?2 R:R:L388 4 0 Yes No 0 7 0 1
L:L:F6 R:R:L388 4.87 15 Yes No 0 7 0 1
R:R:A375 R:R:R380 2.77 0 No No 4 5 2 1
L:L:?2 R:R:E387 2.55 0 Yes No 0 8 0 1
R:R:S392 R:R:Y152 2.54 3 No Yes 9 7 2 1
R:R:V36 R:R:W39 2.45 0 No Yes 2 5 2 1
L:L:A21 R:R:W214 1.3 0 No Yes 0 1 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
82.61Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
80.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
78.26Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
76.00Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
75.00Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
75.00Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
72.73Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
72.00Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
72.00Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
70.83Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
69.23Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
69.23Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
68.00Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
66.67Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
66.67Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
65.38Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
65.38Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
64.29Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
64.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
64.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
62.96Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
62.07Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
61.54Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
61.54Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
61.54Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
60.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
60.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
60.00Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
60.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
60.00Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
59.38Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
59.26Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
59.26Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
59.26Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
57.69Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
56.67Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
56.67Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
56.00Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
55.56Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
55.17Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
53.85Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
53.57Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
53.33Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
53.33Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
53.33Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
51.85Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
51.72Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
51.61Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
51.61Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
51.61Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
50.00Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
50.00Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
50.00Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
50.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
50.00Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
50.00Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
48.15Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
46.67Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
46.67Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
46.67Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
46.15Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
45.45Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
45.45Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
45.45Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
44.83Single6FJ3PTH6FJ3-PTH1-PTH
44.83Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
44.83Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
43.33Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
42.31Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
41.94Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
41.94Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
41.94Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
41.38Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
40.91Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
40.91Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
40.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
40.00Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
39.29Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
39.13Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
39.13Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
39.13Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
38.71Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
38.46Single5EE7MK08935EE7-Glucagon-MK0893
37.93Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
37.93Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
37.93Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
37.93Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
37.93Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
37.93Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
37.50Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
37.50Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
37.50Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
37.04Single4XT1Fractalkine4XT1-US28-Fractalkine
37.04Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
37.04Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
37.04Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
36.67Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
36.67Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
36.67Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.36Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
36.11Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
36.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
36.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
36.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
36.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
36.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
36.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
36.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
35.71Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
35.71Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
35.71Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
35.71Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
35.48Single4XT3Fractalkine4XT3-US28-Fractalkine
35.48Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
35.48Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
35.48Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
34.78Single7V3ZCP559407V3Z-CB1-CP55940
34.78Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
34.78Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
34.78Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
34.78Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
34.78Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
34.78Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
34.78Consensushca_on_gpOrthosteric Ligandhca2_on_gp
34.62Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
34.62Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
34.48Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
34.48Consensusangiotensin_onOrthosteric Ligandat1_on
34.48Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.38Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
34.38Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
34.38Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
34.38Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
34.38Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
34.38Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
34.38Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
34.38Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
33.33Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
33.33Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
33.33Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
33.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
33.33Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
33.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
33.33Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
33.33Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
33.33Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
33.33Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
33.33Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
33.33Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
33.33Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
33.33Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
33.33Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
33.33Single8K5BNiacin8K5B-HCA2-Niacin
33.33Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
33.33Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
33.33Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
33.33Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
33.33Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
33.33Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
33.33Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
33.33Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
32.35Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.35Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.35Consensusbombesin_onOrthosteric Ligandbb2_on
32.35Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
32.35Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.26Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
32.26Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
32.26Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
32.26Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
32.26Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
32.26Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
32.14Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
32.14Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
32.14Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
32.14Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
32.14Consensuslpl_onOrthosteric Ligands1p_on lpa_on
32.14Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
32.14Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.00Single5XR8AM8415XR8-CB1-AM841
32.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
32.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
32.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
31.82Single5U09Taranabant5U09-CB1-Taranabant
31.82Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
31.82Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
31.82Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
31.82Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
31.82Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
31.82Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
31.82Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
31.03Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
31.03Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
31.03Single7XNACYN1548067XNA-SST2-CYN154806
31.03Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
31.03Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
31.03Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
31.03Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
30.77Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
30.77Single6OS2TRV0266OS2-AT1-TRV026
30.77Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
30.77Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
30.77Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
30.77Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
30.77Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.77Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
30.77Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
30.77Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
30.77Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
30.77Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
30.77Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
30.43Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
30.43Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
30.43Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
30.43Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
30.43Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
30.43Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
30.43Single8K5CAcipimox8K5C-HCA2-Acipimox
30.43Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
30.43Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
30.43Consensushca_onOrthosteric Ligandhca2_on
30.30Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
30.30Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
30.30Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
30.30Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
30.00Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
30.00Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
30.00Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
29.73Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
29.73Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
29.63Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
29.63Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
29.63Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
29.63Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
29.63Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
29.63Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
29.63Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
29.63Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
29.63Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
29.17Single4YAYZD-71554YAY-AT1-ZD-7155
29.17Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
29.17Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
29.17Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
29.17Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
29.17Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
29.17Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
29.17Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
29.17Single8K5DGSK2560738K5D-HCA2-GSK256073
29.17Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
29.17Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
29.17Single9B9ZA1AKO9B9Z-CB1-A1AKO
29.17Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
29.17Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
29.17Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
29.03Single6JODAngiotensin II6JOD-AT2-Angiotensin II
29.03Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
29.03Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.03Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
29.03Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
29.03Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
29.03Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
28.57Single4UG2CGS216804UG2-A2A-CGS21680
28.57Single5ZTYAM102575ZTY-CB2-AM10257
28.57Single6IGKEndothelin-36IGK-ETB-Endothelin-3
28.57Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
28.57Single7SK9CCX6627SK9-ACKR3-CCX662
28.57Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
28.57Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
28.57Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
28.57Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
28.57Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
28.57Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
28.57Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
28.57Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
28.57Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
28.57Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
28.57Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
28.12Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
28.12Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
28.12Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
28.12Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
28.12Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
28.12Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
28.12Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
28.00Single5C1MBU725C1M-μ-BU72
28.00Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
28.00Single7C4SS1P7C4S-S1P3-S1P
28.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
28.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
28.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
28.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
28.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
28.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
28.00Single8S4DCMF-0198S4D-Apelin-CMF-019
28.00Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
28.00Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
28.00Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
27.78Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
27.78Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
27.78Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
27.59Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
27.59Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
27.59Single7QA8Peptide7QA8-STE2-Peptide
27.59Single7QA8Peptide7QA8-STE2-Peptide
27.59Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
27.59Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
27.59Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
27.59Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
27.59Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
27.59Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
27.59Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
27.59Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
27.59Consensussomatostatin_offOrthosteric Ligandsst2_off
27.27Single6LI0C176LI0-GPR52-C17
27.27Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
27.27Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
27.03Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
26.92Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
26.92Single5XRAAM115425XRA-CB1-AM11542
26.92Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
26.92Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
26.92Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
26.92Single7FEECP559407FEE-CB1-CP55940-ZCZ011
26.92Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
26.92Single7TUYGSK682753A7TUY-GPR183-GSK682753A
26.92Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
26.92Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
26.92Single8E0GBU728E0G-μ-BU72
26.92Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
26.92Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
26.92Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
26.92Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
26.92Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
26.92Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
26.92Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
26.92Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
26.92Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
26.92Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
26.92Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
26.92Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
26.92Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
26.83Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
26.67Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
26.67Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
26.67Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
26.67Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
26.67Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
26.67Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
26.67Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
26.67Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
26.47Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
26.47Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
26.47Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
26.47Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
26.47Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
26.47Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
26.47Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
26.09Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
26.09Single4BWBNeurotensin4BWB-NTS1-Neurotensin
26.09Single5ZKQABT-4915ZKQ-PAF-ABT-491
26.09Single6AKXA4R6AKX-CCR5-A4R
26.09Single6AKYMaraviroc6AKY-CCR5-Maraviroc
26.09Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
26.09Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
26.09Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
26.09Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
26.09Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
26.09Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
26.09Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
26.09Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
26.09Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
26.09Consensusangiotensin_offOrthosteric Ligandat1_off
26.09Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
26.09Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
25.93Single4XEENeurotensin4XEE-NTS1-Neurotensin
25.93Single4XESNeurotensin4XES-NTS1-Neurotensin
25.93Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
25.93Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
25.93Single6KQICP559406KQI-CB1-CP55940-Org27569
25.93Single6YVRNTS8-136YVR-NTS1-NTS8-13
25.93Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
25.93Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
25.93Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
25.93Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
25.93Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
25.93Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
25.93Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
25.93Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
25.93Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single8XYIVUF106618XYI-CXCR3-VUF10661
25.93Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
25.93Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
25.93Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
25.93Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
25.93Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
25.93Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
25.93Consensuslpa_offOrthosteric Ligandlpa1_off
25.93Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
25.81Single6W25SHU91196W25-MC4-SHU9119-Ca
25.81Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
25.81Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
25.81Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
25.81Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.81Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.81Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
25.81Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
25.81Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
25.81Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
25.81Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
25.81Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
25.81Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
25.81Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
25.71Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
25.71Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
25.71Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
25.71Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
25.71Consensusbradykinin_onOrthosteric Ligandbk2_on
25.71Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
25.71Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
25.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
25.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
25.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
25.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
25.00Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
25.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
25.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
25.00Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
25.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
25.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
25.00Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
25.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
25.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
25.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
25.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
25.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
25.00Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
25.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
25.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
25.00Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
25.00Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
25.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
25.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
25.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
25.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
25.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
25.00Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
25.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
25.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
25.00Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
25.00Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
25.00Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
25.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
25.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
25.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
25.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
25.00Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
25.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
25.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
25.00Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.00Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
25.00Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
25.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
25.00Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
25.00Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
25.00Consensuschemerin_onOrthosteric Ligandcml1_on
25.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
25.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
25.00Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
25.00Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
25.00Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
25.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
25.00Consensusprostanoid_offOrthosteric Ligandep_off dp_off
25.00Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
25.00Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
25.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
25.00Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
24.32Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
24.32Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
24.24Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
24.24Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
24.24Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
24.24Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
24.24Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
24.24Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
24.24Single8ZRTET-18ZRT-ETB-ET-1
24.24Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
24.24Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
24.24Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
24.24Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
24.24Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
24.24Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
24.14Single3NY9ICI118-5513NY9-β2-ICI118-551
24.14Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
24.14Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
24.14Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
24.14Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
24.14Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
24.14Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
24.14Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
24.14Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single8QJ2pN1628QJ2-MC4-pN162-Gs
24.14Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
24.14Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
24.14Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
24.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
24.00Single6PS1Timolol6PS1-β2-Timolol
24.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
24.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
24.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
24.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
24.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
24.00Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
24.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
24.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
24.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
24.00Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
24.00Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
24.00Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
24.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
24.00Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
24.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
24.00Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
24.00Single9CHXS-Carazolol9CHX-β2-S-Carazolol
24.00Consensusa3_onOrthosteric Liganda3a_on
24.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
24.00Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
24.00Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
23.68Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
23.53Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
23.53Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
23.53Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
23.53Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
23.53Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
23.33Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
23.33Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
23.33Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
23.33Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
23.33Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
23.33Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
23.33Single8WDTphotoNECA8WDT-A2A-photoNECA
23.33Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.33Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
23.33Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
23.33Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
23.33Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
23.33Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
23.08Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
23.08Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
23.08Single6D26Fevipiprant6D26-DP2-Fevipiprant
23.08Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
23.08Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
23.08Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
23.08Single7C61Ergotamine7C61-5-HT1B-Ergotamine
23.08Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
23.08Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
23.08Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
23.08Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
23.08Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
23.08Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.08Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
23.08Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
23.08Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
23.08Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
23.08Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
23.08Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8JXSPF-61428JXS-D1-PF-6142
23.08Single8TF5Oleic acid8TF5-GPR6-Oleic acid
23.08Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
23.08Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
23.08Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
23.08Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
23.08Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
23.08Consensusa3_on_gpOrthosteric Liganda3a_on_gp
23.08Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
23.08Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
23.08Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
23.08Consensusblt_offOrthosteric Ligandblt1_off
23.08Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
23.08Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
23.08Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
23.08Consensusdp_offOrthosteric Liganddp2_off
23.08Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
23.08Consensusep_offOrthosteric Ligandep4_off
23.08Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
23.08Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
23.08Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
23.08Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.08Consensustrace-amine_onOrthosteric Ligandta1_on
22.86Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
22.86Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
22.73Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
22.73Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
22.73Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
22.58Single3QAKUK-4320973QAK-A2A-UK-432097
22.58Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
22.58Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
22.58Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
22.58Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
22.58Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
22.58Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
22.58Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
22.58Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
22.58Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
22.58Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
22.58Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
22.58Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
22.58Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
22.58Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
22.58Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
22.58Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
22.58Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
22.58Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
22.58Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
22.22Single2YDVNECA2YDV-A2A-NECA
22.22Single3P0GBI1671073P0G-β2-BI167107
22.22Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
22.22Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
22.22Single4BV0Neurotensin4BV0-NTS1-Neurotensin
22.22Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
22.22Single4UHRCGS216804UHR-A2A-CGS21680
22.22Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
22.22Single5G53NECA5G53-A2A-NECA-Gs
22.22Single6IGLIRL16206IGL-ETB-IRL1620
22.22Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
22.22Single6OS1TRV0266OS1-AT1-TRV026
22.22Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
22.22Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
22.22Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
22.22Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
22.22Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
22.22Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
22.22Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
22.22Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
22.22Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
22.22Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
22.22Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
22.22Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
22.22Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
22.22Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
22.22Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
22.22Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
22.22Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
22.22Single8IY6Endothelin-18IY6-ETB-Endothelin-1
22.22Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
22.22Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
22.22Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
22.22Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
22.22Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
22.22Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
22.22Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
22.22Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
22.22Consensusa2_onOrthosteric Liganda2b_on
22.22Consensusa2_on_gpOrthosteric Liganda2b_on_gp
22.22Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
22.22Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
22.22Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
22.22Consensusendothelin_onOrthosteric Ligandetb_on eta_on
22.22Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
22.22Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
22.22Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
22.22Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
22.22Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
22.22Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
22.22Consensuslpa_onOrthosteric Ligandlpa1_on
22.22Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
22.22Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusneurotensin_onOrthosteric Ligandnts1_on
22.22Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
22.22Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
22.22Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
21.88Single3OE0CVX153OE0-CXCR4-CVX15
21.88Single5WF5UK-4320975WF5-A2A-UK-432097
21.88Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
21.88Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
21.88Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
21.88Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
21.88Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
21.88Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.88Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
21.88Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
21.88Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
21.88Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
21.88Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
21.74Single3OE9IT1t3OE9-CXCR4-IT1t
21.74Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
21.74Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
21.74Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
21.74Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
21.74Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
21.74Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
21.74Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
21.74Single9B9Y7DY9B9Y-CB1-7DY
21.74Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
21.74Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
21.43Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
21.43Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
21.43Single6A93Risperidone6A93-5-HT2A-Risperidone
21.43Single6IIURamatroban6IIU-TP-Ramatroban
21.43Single6MXTSalmeterol6MXT-β2-Salmeterol
21.43Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
21.43Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
21.43Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
21.43Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
21.43Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
21.43Single7K15MKD0467K15-BLT1-MKD046-Na
21.43Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
21.43Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
21.43Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
21.43Single7YITNalfurafine7YIT-κ-Nalfurafine
21.43Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
21.43Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
21.43Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
21.43Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
21.43Single8JJ8Formoterol8JJ8-β2-Formoterol
21.43Single8JJLOlodaterol8JJL-β2-Olodaterol
21.43Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
21.43Single8JWY2-1188JWY-A2A-2-118
21.43Single8JWZAB9288JWZ-A2A-AB928-Na
21.43Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
21.43Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
21.43Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
21.43Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
21.43Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
21.43Consensusalpha1_offOrthosteric Ligandalpha1a_off
21.43Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
21.43Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
21.43Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
21.43Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
21.43Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
21.43Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
21.43Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
21.43Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
21.43Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
21.43Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
21.43Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
21.43Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
21.43Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
21.43Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
21.43Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
21.43Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
21.21Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
21.21Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
21.21Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
21.21Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
21.21Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
21.21Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
21.21Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
21.21Consensusvasop-oxy_onOrthosteric Ligandv2_on
21.21Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
21.05Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
20.83Single3PWHZM-2413853PWH-A2A-ZM-241385
20.83Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
20.83Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
20.83Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
20.83Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
20.83Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
20.83Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
20.83Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
20.83Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
20.83Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
20.83Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
20.83Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
20.83Single8GNGIstradefylline8GNG-A2A-Istradefylline
20.83Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
20.83Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
20.83Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
20.83Single8IWESpermidine8IWE-TA9-Spermidine
20.83Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
20.83Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
20.83Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
20.83Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
20.83Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
20.83Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
20.83Single9BA0A1AKN9BA0-CB1-A1AKN
20.83Consensusalpha2_offOrthosteric Ligandalpha2c_off
20.69Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
20.69Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
20.69Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
20.69Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
20.69Single5X93K-87945X93-ETB-K-8794
20.69Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
20.69Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
20.69Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
20.69Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
20.69Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
20.69Single7EZCUKA7EZC-A2A-UKA
20.69Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
20.69Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
20.69Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
20.69Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
20.69Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
20.69Single7UM4AS26747237UM4-5-HT5A-AS2674723
20.69Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
20.69Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.69Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
20.69Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
20.69Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
20.69Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
20.69Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
20.69Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.69Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
20.69Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
20.69Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
20.69Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
20.69Consensusendothelin_offOrthosteric Ligandetb_off
20.69Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
20.69Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
20.69Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
20.59Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
20.59Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
20.59Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
20.59Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
20.45Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
20.00Single2YDOAdenosine2YDO-A2A-Adenosine
20.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
20.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
20.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
20.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
20.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
20.00Single6PS0S-Carazolol6PS0-β2-S-Carazolol
20.00Single6PS4ICI118-5516PS4-β2-ICI118-551
20.00Single6PS5S-Propranolol6PS5-β2-S-Propranolol
20.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
20.00Single6PT3DPI-2876PT3-δ-DPI-287
20.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
20.00Single7AROLUF58337ARO-A2A-LUF5833-Na
20.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
20.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
20.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single7T32ZM-2413857T32-A2A-ZM-241385
20.00Single7UL3Famotidine7UL3-H2-Famotidine
20.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
20.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
20.00Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
20.00Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
20.00Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
20.00Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
20.00Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
20.00Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
20.00Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
20.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
20.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
20.00Single8IHKAcifran8IHK-HCA3-Acifran
20.00Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
20.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
20.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
20.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
20.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
20.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
20.00Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
20.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
20.00Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
20.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
20.00Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
20.00Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
20.00Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
20.00Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
20.00Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
20.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
20.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
20.00Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
20.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
20.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
20.00Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
20.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
20.00Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
20.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
20.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
19.44Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
19.44Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
19.44Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
19.35Single4IARErgotamine4IAR-5-HT1B-Ergotamine
19.35Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
19.35Single7F8XNN90567F8X-CCKA-NN9056
19.35Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
19.35Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
19.35Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
19.35Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
19.35Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
19.35Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
19.35Single8KIGSHU91198KIG-MC3-SHU9119-Ca
19.35Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
19.35Single8WKYPG-9348WKY-MC4-PG-934
19.35Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.35Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
19.35Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
19.35Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
19.23Single2Y04Salbutamol2Y04-β1-Salbutamol
19.23Single3NY8ICI118-5513NY8-β2-ICI118-551
19.23Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
19.23Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
19.23Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
19.23Single4GBRS-Carazolol4GBR-β2-S-Carazolol
19.23Single4QKX35V4QKX-β2-35V
19.23Single5DHHSB-6121115DHH-NOP-SB-612111
19.23Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
19.23Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
19.23Single5T04Neurotensin5T04-NTS1-Neurotensin
19.23Single5TGZAM65385TGZ-CB1-AM6538
19.23Single5UENDU1725UEN-A1-DU172
19.23Single5UIGCmpd-15UIG-A2A-Cmpd-1
19.23Single6D27CAY104716D27-DP2-CAY10471
19.23Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
19.23Single6H7MSalbutamol6H7M-β1-Salbutamol
19.23Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
19.23Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
19.23Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
19.23Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
19.23Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
19.23Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
19.23Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
19.23Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
19.23Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
19.23Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
19.23Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
19.23Single7UL4Alvimopan7UL4-μ-Alvimopan
19.23Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
19.23Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
19.23Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
19.23Single7WC7Lisuride7WC7-5-HT2A-Lisuride
19.23Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
19.23Single7YXAONO-54306087YXA-S1P5-ONO-5430608
19.23Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
19.23Single8CU6LJ-45178CU6-A2A-LJ-4517
19.23Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
19.23Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
19.23Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
19.23Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
19.23Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
19.23Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
19.23Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
19.23Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
19.23Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
19.23Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
19.23Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
19.23Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
19.23Single8JJOAlprenolol8JJO-β2-Alprenolol
19.23Single8JXRLSD8JXR-D1-LSD
19.23Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
19.23Single8RLNLUF58348RLN-A2A-LUF5834
19.23Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
19.23Single8T1WCVN4248T1W-GPR6-CVN424
19.23Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
19.23Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
19.23Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
19.23Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
19.23Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
19.23Consensus5ht5_onOrthosteric Ligand5ht5a_on
19.23Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
19.23Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
19.23Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
19.23Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
19.23Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
19.23Consensusblt_onOrthosteric Ligandblt1_on
19.23Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
19.23Consensusdopamine_offOrthosteric Ligandd2_off d3_off
19.23Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
19.23Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
19.23Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
19.23Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
19.23Consensusleukotriene_onOrthosteric Ligandblt_on
19.23Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
19.23Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
19.05Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
19.05Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
18.92Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
18.92Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
18.75Single6HLOAprepitant6HLO-NK1-Aprepitant
18.75Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
18.75Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
18.75Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
18.75Single7SK5CXCL127SK5-ACKR3-CXCL12
18.75Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
18.52Single2RH1S-Carazolol2RH1-β2-S-Carazolol
18.52Single2Y03Isoprenaline2Y03-β1-Isoprenaline
18.52Single2YCWS-Carazolol2YCW-β1-S-Carazolol
18.52Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
18.52Single5D6LS-Carazolol5D6L-β2-S-Carazolol
18.52Single5JQHS-Carazolol5JQH-β2-S-Carazolol
18.52Single5N2RPSB-365N2R-A2A-PSB-36-Na
18.52Single5N2SPSB365N2S-A1-PSB36
18.52Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
18.52Single5TVNLSD5TVN-5-HT2B-LSD
18.52Single5WIUNemonapride5WIU-D4-Nemonapride
18.52Single5WIVNemonapride5WIV-D4-Nemonapride-Na
18.52Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
18.52Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
18.52Single6E67BI1671076E67-β2-BI167107-Gs (fused)
18.52Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
18.52Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
18.52Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
18.52Single6PS6Timolol6PS6-β2-Timolol
18.52Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
18.52Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
18.52Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
18.52Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
18.52Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
18.52Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
18.52Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
18.52Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
18.52Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
18.52Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
18.52Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.52Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.52Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
18.52Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
18.52Single8QOTNanobody-E8QOT-μ-Nanobody-E
18.52Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
18.52Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
18.52Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
18.52Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
18.52Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
18.52Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
18.52Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
18.52Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
18.52Consensusadenosine_offOrthosteric Liganda1_off a2_off
18.52Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
18.52Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
18.52Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
18.52Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
18.52Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
18.52Consensusamine_offonOrthosteric Ligandamine_off amine_on
18.52Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
18.52Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
18.52Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
18.52Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
18.52Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.52Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
18.52Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
18.52Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
18.52Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.52Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.42Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
18.42Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
18.18Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
18.18Single6PT2KGCHM076PT2-δ-KGCHM07
18.18Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
18.18Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8A2OTheophylline8A2O-A2A-Theophylline-Na
18.18Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single9CHUNoradrenaline9CHU-β2-Noradrenaline
18.18Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
18.18Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.18Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.18Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.95Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
17.95Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
17.86Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
17.86Single4DJHJDTic4DJH-κ-JDTic
17.86Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
17.86Single5D5AS-Carazolol5D5A-β2-S-Carazolol
17.86Single5D5BS-Carazolol5D5B-β2-S-Carazolol
17.86Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
17.86Single6H7JIsoprenaline6H7J-β1-Isoprenaline
17.86Single6J21Aprepitant6J21-NK1-Aprepitant
17.86Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
17.86Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
17.86Single6TQ7SB-3348676TQ7-OX1-SB-334867
17.86Single6WGTLSD6WGT-5-HT2A-LSD
17.86Single7B6WCyclazosin7B6W-α1b-Cyclazosin
17.86Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
17.86Single7F1TMIP-1a7F1T-CCR5-MIP-1a
17.86Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
17.86Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
17.86Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
17.86Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
17.86Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
17.86Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
17.86Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
17.86Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
17.86Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
17.86Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
17.86Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
17.86Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
17.86Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
17.86Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
17.86Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
17.86Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
17.86Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.86Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
17.86Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
17.86Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
17.86Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
17.86Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
17.86Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.86Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
17.86Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
17.86Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
17.86Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
17.86Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
17.86Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
17.86Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.86Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
17.86Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
17.86Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
17.86Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
17.86Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
17.86Consensusrelaxin_onOrthosteric Ligandrxfp4_on
17.86Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
17.65Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.65Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
17.65Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
17.65Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
17.65Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
17.39Single3OE6IT1t3OE6-CXCR4-IT1t
17.39Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
17.39Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
17.39Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
17.39Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
17.39Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
17.39Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
17.39Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
17.39Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
17.39Consensus5ht2_onOrthosteric Ligand5ht2b_on
17.39Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
17.39Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
17.24Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
17.24Single3D4STimolol3D4S-β2-Timolol
17.24Single4AMIBucindolol4AMI-β1-Bucindolol
17.24Single4LDEBI1671074LDE-β2-BI167107
17.24Single4RWADIPP-NH24RWA-δ-DIPP-NH2
17.24Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
17.24Single5X33BIIL2605X33-BLT1-BIIL260
17.24Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
17.24Single6CM4Risperidone6CM4-D2-Risperidone
17.24Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
17.24Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
17.24Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
17.24Single6ZG4HTL00099366ZG4-M1-HTL0009936
17.24Single7DFPSpiperone7DFP-D2-Spiperone
17.24Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
17.24Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
17.24Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
17.24Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
17.24Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
17.24Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
17.24Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
17.24Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.24Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
17.24Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
17.24Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
17.24Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
17.24Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
17.24Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
17.24Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
17.24Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
17.24Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
17.24Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
17.24Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
17.24Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
17.24Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
17.24Consensusorexin_onOrthosteric Ligandox2_on
17.24Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.24Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.14Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
17.14Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
17.14Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
17.14Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
17.14Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
17.14Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.67Single6H7LDobutamine6H7L-β1-Dobutamine
16.67Single6IBLArformoterol6IBL-β1-Arformoterol
16.67Single6K1QIRL25006K1Q-ETB-IRL2500
16.67Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
16.67Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
16.67Single7SK3CXCL127SK3-ACKR3-CXCL12
16.67Single7SRQLSD7SRQ-5-HT2B-LSD
16.67Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
16.67Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
16.67Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
16.67Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
16.67Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
16.67Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
16.67Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
16.67Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
16.67Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
16.67Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
16.67Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
16.67Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
16.67Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
16.67Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
16.67Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
16.67Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
16.67Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
16.67Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
16.67Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
16.67Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
16.67Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
16.67Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
16.67Single8XVJMacitentan8XVJ-ETA-Macitentan
16.67Single8XVUCXCL28XVU-CXCR2-CXCL2
16.67Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
16.67Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
16.67Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
16.67Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
16.67Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
16.67Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
16.67Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
16.67Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
16.67Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
16.67Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
16.67Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
16.67Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
16.67Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
16.67Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
16.67Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
16.67Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
16.13Single5WF6UK-4320975WF6-A2A-UK-432097
16.13Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.13Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
16.13Single7XN9L-054,5227XN9-SST2-L-054,522
16.13Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
16.13Single8X5YAstemizole8X5Y-H1-Astemizole
16.13Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
16.13Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
16.13Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
16.13Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
16.00Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
16.00Single3ODUIT1t3ODU-CXCR4-IT1t
16.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
16.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
16.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
16.00Single6B73MP11046B73-κ-MP1104
16.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
16.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
16.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
16.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
16.00Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
16.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
16.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
16.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
16.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
16.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
16.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
16.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
16.00Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
16.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
16.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
16.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
16.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
16.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
16.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
16.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
16.00Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
16.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
16.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
16.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
16.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
16.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
16.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
16.00Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
16.00Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
16.00Single8Y0HVUF114188Y0H-CXCR3-VUF11418
16.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
16.00Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
16.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
16.00Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
16.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
16.00Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
16.00Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
16.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
16.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
16.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.00Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
16.00Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.00Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
16.00Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
16.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
16.00Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
16.00Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
16.00Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
15.79Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
15.62Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
15.62Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
15.62Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
15.62Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.62Single8XWNCXCL88XWN-CXCR2-CXCL8
15.62Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single3REYXAC3REY-A2A-XAC
15.38Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
15.38Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
15.38Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
15.38Single4ZJCSB-6740424ZJC-OX1-SB-674042
15.38Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
15.38Single5IU7Q274563465IU7-A2A-Q27456346-Na
15.38Single5IUBQ274563445IUB-A2A-Q27456344-Na
15.38Single5JTBZM-2413855JTB-A2A-ZM-241385
15.38Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
15.38Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
15.38Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
15.38Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
15.38Single6A94Zotepine6A94-5-HT2A-Zotepine
15.38Single6AQFZM-2413856AQF-A2A-ZM-241385
15.38Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
15.38Single6KUXRS-799486KUX-α2a-RS-79948
15.38Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
15.38Single6MH8ZM-2413856MH8-A2A-ZM-241385
15.38Single6TPGEMPA6TPG-OX2-EMPA
15.38Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
15.38Single6V9SGTPL114036V9S-OX1-GTPL11403
15.38Single6VI4JDTic6VI4-κ-JDTic
15.38Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
15.38Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
15.38Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
15.38Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
15.38Single6ZG9GSK10347026ZG9-M1-GSK1034702
15.38Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
15.38Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
15.38Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
15.38Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
15.38Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
15.38Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
15.38Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
15.38Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
15.38Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
15.38Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
15.38Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
15.38Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
15.38Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
15.38Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
15.38Single8K2WAMG4878K2W-CXCR3-AMG487
15.38Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
15.38Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
15.38Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
15.38Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
15.38Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
15.38Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
15.38Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
15.38Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
15.38Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
15.38Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
15.38Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
15.38Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
15.38Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
15.38Consensusa2_offOrthosteric Liganda2a_off
15.38Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
15.38Consensusalpha1_onOrthosteric Ligandalpha1a_on
15.38Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
15.38Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
15.38Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
15.38Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
15.38Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
15.38Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
15.38Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
15.38Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
15.38Consensusgrh_offOrthosteric Ligandgnrh1_off
15.38Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
15.15Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
15.15Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.15Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
15.15Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
15.15Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
15.00Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
14.81Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
14.81Single2Y01Dobutamine2Y01-β1-Dobutamine
14.81Single2Y02Carmoterol2Y02-β1-Carmoterol
14.81Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
14.81Single3EMLZM-2413853EML-A2A-ZM-241385
14.81Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
14.81Single4DAJTiotropium4DAJ-M3-Tiotropium
14.81Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
14.81Single4EJ4Naltrindole4EJ4-δ-Naltrindole
14.81Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
14.81Single4MQSIperoxo4MQS-M2-Iperoxo
14.81Single4QIMANTA XV4QIM-SMO-ANTA XV
14.81Single4U14Tiotropium4U14-M3-Tiotropium
14.81Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
14.81Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
14.81Single5DHGC-355DHG-NOP-C-35
14.81Single5IU8Q274563475IU8-A2A-Q27456347-Na
14.81Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
14.81Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
14.81Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
14.81Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
14.81Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
14.81Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
14.81Single6DRXLisuride6DRX-5-HT2B-Lisuride
14.81Single6GPSMK08126GPS-CCR2-MK0812
14.81Single6IIVDaltroban6IIV-TP-Daltroban
14.81Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
14.81Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
14.81Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
14.81Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
14.81Single6S0LZM-2413856S0L-A2A-ZM-241385
14.81Single6TOTLemborexant6TOT-OX1-Lemborexant
14.81Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
14.81Single7BU7BI1671077BU7-β1-BI167107
14.81Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
14.81Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
14.81Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
14.81Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
14.81Single7PYRPSB-21157PYR-A2A-PSB-2115
14.81Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
14.81Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
14.81Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
14.81Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
14.81Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
14.81Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
14.81Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
14.81Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
14.81Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
14.81Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
14.81Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
14.81Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
14.81Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
14.81Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
14.81Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
14.81Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
14.81Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
14.81Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
14.81Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
14.81Single8X63Mepyramine8X63-H1-Mepyramine
14.81Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
14.81Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
14.81Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
14.81Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
14.81Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
14.81Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
14.81Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
14.81Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
14.81Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
14.81Consensusalpha2_onOrthosteric Ligandalpha2b_on
14.81Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
14.81Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
14.81Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
14.81Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
14.81Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
14.81Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
14.81Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
14.81Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
14.81Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
14.81Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
14.81Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
14.81Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
14.81Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
14.81Consensushistamine_offOrthosteric Ligandh1_off
14.81Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
14.81Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
14.71Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.71Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
14.71Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
14.71Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
14.71Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
14.71Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
14.29Single2Y00Dobutamine2Y00-β1-Dobutamine
14.29Single4JKVTaladegib4JKV-SMO-Taladegib
14.29Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
14.29Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
14.29Single5CGCHTL142425CGC-mGlu5-HTL14242
14.29Single5IUAQ274563485IUA-A2A-Q27456348-Na
14.29Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
14.29Single5WQCEMPA5WQC-OX2-EMPA
14.29Single5XPRBosentan5XPR-ETB-Bosentan
14.29Single6GPXMK08126GPX-CCR2-MK0812
14.29Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.29Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
14.29Single6LUQHaloperidol6LUQ-D2-Haloperidol
14.29Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
14.29Single6S0QZM-2413856S0Q-A2A-ZM-241385
14.29Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
14.29Single6TP6Filorexant6TP6-OX1-Filorexant
14.29Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
14.29Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
14.29Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
14.29Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
14.29Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
14.29Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
14.29Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
14.29Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
14.29Single7W41PD1762527W41-BB2-PD176252
14.29Single7WC6LSD7WC6-5-HT2A-LSD
14.29Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
14.29Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
14.29Single8GNEKW-63568GNE-A2A-KW-6356-Na
14.29Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
14.29Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
14.29Single8ZMFA1L108ZMF-5-HT2C-A1L10
14.29Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
14.29Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
14.29Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
14.29Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
14.29Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
14.29Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
14.29Consensusbombesin_offOrthosteric Ligandbb2_off
14.29Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.29Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
14.29Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
14.29Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
14.29Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
14.29Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
14.29Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
14.29Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
13.89Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
13.79Single4U15Tiotropium4U15-M3-Tiotropium
13.79Single5V54Methiothepin5V54-5-HT1B-Methiothepin
13.79Single5V56TC1145V56-SMO-TC114
13.79Single5V57TC1145V57-SMO-TC114
13.79Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
13.79Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
13.79Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
13.79Single6J20Aprepitant6J20-NK1-Aprepitant
13.79Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
13.79Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.79Single6OL9Tiotropium6OL9-M5-Tiotropium
13.79Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
13.79Single7PX4PSB-21137PX4-A2A-PSB-2113
13.79Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
13.79Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
13.79Single8EA0Iperoxo8EA0-M3-Iperoxo
13.79Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
13.79Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
13.79Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
13.79Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
13.79Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
13.79Single9BJKNAM9BJK-μ-Naloxone-NAM
13.79Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
13.79Consensus5ht1_offOrthosteric Ligand5ht1b_off
13.79Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
13.79Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
13.79Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
13.79Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
13.79Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.79Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
13.79Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
13.79Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
13.79Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
13.64Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
13.64Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
13.64Single8HS2Fab0468HS2-GPR20-Fab046
13.64Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
13.64Single8PWNTheophylline8PWN-A2A-Theophylline
13.64Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
13.64Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
13.33Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
13.33Single4N4WSANT-14N4W-SMO-SANT-1
13.33Single5CXVTiotropium5CXV-M1-Tiotropium
13.33Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
13.33Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
13.33Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
13.33Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8XQJJN2418XQJ-Apelin-JN241
13.33Single8XWMCXCL68XWM-CXCR2-CXCL6
13.33Single8XWSCXCL58XWS-CXCR2-CXCL5
13.33Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
13.33Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
13.33Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
13.33Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
13.33Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
13.33Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
13.04Single3OE8IT1t3OE8-CXCR4-IT1t
13.04Single3RFMCaffeine3RFM-A2A-Caffeine
13.04Single6TQ9SB-4081246TQ9-OX1-SB-408124
13.04Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
13.04Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
13.04Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
13.04Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
13.04Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
13.04Consensusp2y_offOrthosteric Ligandp2y1_off
12.90Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
12.90Single5CGDHTL142425CGD-mGlu5-HTL14242
12.90Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
12.90Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
12.90Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Single8XWFCXCL38XWF-CXCR2-CXCL3
12.90Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
12.50Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
12.50Single4XNWMRS25004XNW-P2Y1-MRS2500
12.50Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
12.50Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
12.50Single6KNMJN241-96KNM-Apelin-JN241-9
12.50Single6ME5Agomelatine6ME5-MT1-Agomelatine
12.50Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
12.50Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
12.50Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
12.50Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
12.50Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.50Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
12.50Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
12.50Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
12.50Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
12.50Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
12.50Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
12.50Single8XQJJN2418XQJ-Apelin-JN241
12.50Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
12.50Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
12.50Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
12.12Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
12.12Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.12Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
12.12Single8IEBA1LYA8IEB-GPR156-A1LYA
12.12Single8IEIA1LYA8IEI-GPR156-A1LYA
12.12Single8IEPA1LYA8IEP-GPR156-A1LYA
12.12Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
12.12Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
12.12Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.12Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.12Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
12.12Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
12.00Single3PBLEticlopride3PBL-D3-Eticlopride
12.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
12.00Single5L7IVismodegib5L7I-SMO-Vismodegib
12.00Single6HLLCP999946HLL-NK1-CP99994
12.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
12.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
12.00Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
12.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
12.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
12.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
12.00Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
12.00Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.00Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.00Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
12.00Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
12.00Consensusgq_nucleotideOrthosteric Ligandgq_p2y
12.00Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
12.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
11.54Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
11.54Single4QINSAG1.54QIN-SMO-SAG1.5
11.54Single4S0VSuvorexant4S0V-OX2-Suvorexant
11.54Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
11.54Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
11.54Single5WS3EMPA5WS3-OX2-EMPA
11.54Single6DS0Ly2660976DS0-5-HT2B-Ly266097
11.54Single6ME9Ramelteon6ME9-MT2-Ramelteon
11.54Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
11.54Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.54Single6TODEMPA6TOD-OX1-EMPA-Na
11.54Single6TPJSuvorexant6TPJ-OX2-Suvorexant
11.54Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
11.54Single7F8ULintitript7F8U-CCKA-Lintitript
11.54Single7F8YDevazepide7F8Y-CCKA-Devazepide
11.54Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.54Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
11.54Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
11.54Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
11.54Single7XRRLemborexant7XRR-OX2-Lemborexant
11.54Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
11.54Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
11.54Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
11.54Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.54Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.54Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
11.54Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
11.54Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
11.11Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
11.11Single3RZECidoxepin3RZE-H1-Cidoxepin
11.11Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
11.11Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
11.11Single5UVIZM-2413855UVI-A2A-ZM-241385
11.11Single6IQLL7458706IQL-D4-L745870
11.11Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
11.11Single6TP3Nemorexant6TP3-OX1-Nemorexant
11.11Single6TPNHTL66416TPN-OX2-HTL6641
11.11Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
11.11Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
11.11Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
11.11Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
11.11Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
11.11Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
11.11Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
11.11Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
11.11Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
11.11Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
11.11Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
11.11Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
11.11Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
11.11Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
11.11Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9BJKNaloxone9BJK-μ-Naloxone-NAM
11.11Consensusopsins_offOrthosteric Ligandrhodopsin_off
11.11Consensussensory_offOrthosteric Ligandopsins_off
10.71Single5DSGTiotropium5DSG-M4-Tiotropium
10.71Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Single7F83PF-051904577F83-Ghrelin-PF-05190457
10.71Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
10.71Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
10.71Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
10.71Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
10.71Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
10.71Single8X64Desloratadine8X64-H1-Desloratadine
10.71Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
10.71Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
10.71Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
10.71Single9IYAONO-97105319IYA-GPR55-ONO-9710531
10.71Consensuscck_offOrthosteric Ligandccka_off
10.71Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
10.71Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
10.34Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
10.34Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
10.34Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
10.34Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
10.34Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
10.34Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
10.34Single7SINNPS-21437SIN-CaS-NPS-2143
10.34Single7SINNPS-21437SIN-CaS-NPS-2143
10.34Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
10.34Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
10.34Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
10.34Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
10.34Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
10.34Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
10.34Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
10.34Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
10.00Single5TZRMK86665TZR-FFA1-MK8666
10.00Single6E59L-7607356E59-NK1-L-760735
10.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
10.00Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
10.00Single7R0CAVP7R0C-V2-AVP-Arrestin2
10.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
10.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
10.00Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
10.00Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
10.00Single8XVLZibotentan8XVL-ETA-Zibotentan
10.00Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
10.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
10.00Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
10.00Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
10.00Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
10.00Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
10.00Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
10.00Consensustachykinin_offOrthosteric Ligandnk1_off
9.68Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
9.68Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
9.68Single4PY02MeSATP4PY0-P2Y12-2MeSATP
9.68Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
9.68Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
9.68Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
9.68Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
9.68Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
9.68Single8XWACXCL18XWA-CXCR2-CXCL1
9.38Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
9.38Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
9.38Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
9.38Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
9.09Single5MZPCaffeine5MZP-A2A-Caffeine-Na
9.09Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
9.09Single8IEIA1LYA8IEI-GPR156-A1LYA
9.09Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
9.09Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
9.09Consensuskisspeptin_onOrthosteric Ligandkiss1_on
8.82Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.82Single8IEPA1LYA8IEP-GPR156-A1LYA
8.82Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.82Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.82Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.82Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
8.70Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
8.70Single7WC4Serotonin7WC4-5-HT2A-Serotonin
8.57Single8IEBA1LYA8IEB-GPR156-A1LYA
8.33Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
8.33Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
8.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
8.33Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
8.33Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
8.33Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
8.33Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
8.33Consensussensory_onOrthosteric Ligandopsins_on
8.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
8.00Single3UZAGTPL92363UZA-A2A-GTPL9236
8.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
8.00Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
8.00Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
8.00Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
8.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
8.00Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
8.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
8.00Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
8.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
8.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
8.00Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
8.00Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.00Consensusgi_sensoryOrthosteric Ligandgi_opsins
8.00Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.00Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.00Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
8.00Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
8.00Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
7.69Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
7.69Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
7.69Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
7.69Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
7.69Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
7.69Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
7.69Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
7.69Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
7.69Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
7.69Single7UL2SR486927UL2-NTS1-SR48692-Na
7.69Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
7.69Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
7.69Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
7.69Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
7.69Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Consensusneurotensin_offOrthosteric Ligandnts1_off
7.69Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
7.41Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
7.41Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
7.41Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
7.41Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
7.41Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
7.41Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
7.41Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
7.41Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
7.41Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.41Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.41Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.41Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
7.41Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
7.41Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
7.41Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
7.41Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
7.41Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
7.41Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
7.41Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.41Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
7.41Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.41Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.41Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
7.14Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
7.14Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
7.14Single6TPKRetosiban6TPK-OT-Retosiban
7.14Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
7.14Single7VODCariprazine7VOD-5-HT2A-Cariprazine
7.14Single7VV6C48/807VV6-MRGPRX2-C48/80
7.14Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
7.14Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
7.14Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
7.14Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
7.14Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
7.14Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.14Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
7.14Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
7.14Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
7.14Consensusvasop-oxy_offOrthosteric Ligandot_off
6.90Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
6.90Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
6.90Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
6.90Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
6.90Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
6.90Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
6.90Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.90Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
6.90Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
6.90Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
6.67Single4NTJAZD12834NTJ-P2Y12-AZD1283
6.67Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
6.67Single6HLPNetupitant6HLP-NK1-Netupitant
6.67Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
6.67Single6Z4SSR486926Z4S-NTS1-SR48692
6.67Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
6.67Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
6.67Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.67Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
6.67Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
6.67Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
6.67Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
6.67Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
6.67Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
6.45Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
6.45Single7P2L4YI7P2L-mGlu5-4YI
6.45Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
6.45Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
6.45Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
6.45Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.45Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
6.45Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
6.25Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
6.25Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
6.25Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
6.25Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
6.06Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
6.06Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
5.71Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
5.56Single7SHEPI; PE7SHE-GPR158-PI; PE
5.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.00Single6D35Cholesterol6D35-SMO-Cholesterol
5.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
5.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
5.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
5.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
5.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
5.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
5.00Single7DTTCa7DTT-CaS-Ca-Ca
5.00Single7DTTCa7DTT-CaS-Ca-Ca
5.00Single7DTUTryptophan7DTU-CaS-Tryptophan
5.00Single7DTUTryptophan7DTU-CaS-Tryptophan
5.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.00Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
5.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
5.00Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
5.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
5.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
5.00Single7XW7K1-707XW7-TSH-K1-70
5.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
5.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
5.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
5.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
5.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
5.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
5.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
5.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
5.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
5.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
5.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
5.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
5.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.00Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
5.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
5.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
5.00Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
5.00Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
5.00Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
5.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8WVXNorrin8WVX-LGR4-Norrin
5.00Single8WVYNorrin8WVY-LGR4-Norrin
5.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.00Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
5.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
5.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
5.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.76Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.76Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.76Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.76Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.76Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.76Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.76Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.76Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.55Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
4.55Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.55Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.55Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
4.35Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.35Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
4.35Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
4.35Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
4.35Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.35Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
4.17Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
4.17Single5L7DCholesterol5L7D-SMO-Cholesterol
4.17Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
4.17Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
4.17Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.00Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
3.85Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
3.85Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
3.85Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
3.85Single8JPSCCL78JPS-ACKR1-CCL7
3.85Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.85Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.70Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
3.70Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
3.70Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
3.70Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
3.70Single6TP4ACT-4622066TP4-OX1-ACT-462206
3.70Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.70Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
3.70Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.70Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
3.70Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
3.57Single4XNVBPTU4XNV-P2Y1-BPTU
3.57Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
3.57Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
3.57Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
3.45Single6FFIMMPEP6FFI-mGlu5-MMPEP
3.45Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
3.45Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
3.45Single6ZINSR486926ZIN-NTS1-SR48692
3.45Single8IYXYL-3658IYX-GPR34-YL-365
3.45Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
3.45Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
3.33Single6FFHFenobam6FFH-mGlu5-Fenobam
3.23Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
3.23Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.23Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.12Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.03Single7SHEPI; PE7SHE-GPR158-PI; PE
3.03Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
2.94Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.78Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.78Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.63Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.63Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.56Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.38Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

PDB Summary
PDB 7FIM
Class B1
SubFamily Peptide
Type Glucagon
SubType GLP-1
Species Homo Sapiens
Ligand Tirzepatide
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.4
Date 2022-03-02
D.O.I. 10.1038/s41467-022-28683-0
Net Summary
Imin 2.79
Number of Linked Nodes 993
Number of Links 1177
Number of Hubs 171
Number of Links mediated by Hubs 642
Number of Communities 42
Number of Nodes involved in Communities 245
Number of Links involved in Communities 323
Path Summary
Number Of Nodes in MetaPath 146
Number Of Links MetaPath 145
Number of Shortest Paths 2262889
Length Of Smallest Path 3
Average Path Length 45.4815
Length of Longest Path 88
Minimum Path Strength 0.97
Average Path Strength 6.61416
Maximum Path Strength 20.785
Minimum Path Correlation 0.7
Average Path Correlation 0.990033
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.78571
Average % Of Corr. Nodes 43.6665
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.1843
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Ras-like P-loop GTPases   • G protein-coupled receptor-like   • FnI-like domain   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • G protein-coupled receptor-like   • FnI-like domain   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeAIB
PDB ResiduesL:L:?2 L:L:?13
Environment DetailsOpen EMBL-EBI Page
CodeAIB
Name2-aminoisobutyric acid
Synonymsα,α-dimethylglycine
Identifier
FormulaC4 H9 N O2
Molecular Weight103.12
SMILES
PubChem5245672
Formal Charge0
Total Atoms16
Total Chiral Atoms0
Total Bonds15
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>7FIM_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP04896
Sequence
>7FIM_Chain_A
QRNEEKAQR EANKKIEKQ LQKDKQVYR ATHRLLLLG AGESGKNTI 
VKQMRILHS GIFETKFQV DKVNFHMFD VGAQRDERR KWIQCFNDV 
TAIIFVVAS SNRLQAALK LFDSIWNNK WLRDTSVIL FLNKQDLLA 
EKVLAGKSK IEDYFPEFA RYTTPEDAT PEPGEDPRV TRAKYFIRD 
EFLRISTAS GDGRHYCYP HFTENIRRV FNDCRDIIQ RMHLRQYEL 
L


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP43220
Sequence
>7FIM_Chain_R
ATVSLWETV QKWREYRRQ CQRSLTEDP PPATDLFCN RTFDEYACW 
PDGEPGSFV NVSCPWYLP WASSVPQGH VYRFCTAEG LWLQKDNSS 
LPWRDLSEC EESEEQLLF LYIIYTVGY ALSFSALVI ASAILLGFR 
HLHCTRNYI HLNLFASFI LRALSVFIK DAALKWMYS TAAQQHQWD 
GLLSYQDSL SCRLVFLLM QYCVAANYY WLLVEGVYL YTLLAFSVL 
SEQWIFRLY VSIGWGVPL LFVVPWGIV KYLYEDEGC WTRNSNMNY 
WLIIRLPIL FAIGVNFLI FVRVICIVV SKLKADIKC RLAKSTLTL 
IPLLGTHEV IFAFVMDEH ARGTLRFIK LFTELSFTS FQGLMVAIL 
YCFVNNEVQ LEFRKSWER WRLE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>7FIM_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9IVMB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN3318839chim(NtGi1-Gs)/β2/γ23.222024-11-1310.1016/j.apsb.2024.09.002
9IVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN33188393.222024-11-1310.1016/j.apsb.2024.09.002
8YW3B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-Gs/β1/γ22.682024-09-18doi.org/10.1038/s41421-024-00700-0
8YW3 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-2.682024-09-18doi.org/10.1038/s41421-024-00700-0
8WG7B1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.542024-03-0610.1038/s41421-024-00649-0
8WG7 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.542024-03-0610.1038/s41421-024-00649-0
8JISB1PeptideGlucagonGLP-1Homo sapiensPeptide-15-chim(NtGi1-Gs)/β1/γ22.462023-11-0810.1073/pnas.2303696120
8JIS (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-15-2.462023-11-0810.1073/pnas.2303696120
8JIRB1PeptideGlucagonGLP-1Homo sapiensSAR425899-chim(NtGi1-Gs)/β1/γ22.572023-09-0610.1073/pnas.2303696120
8JIR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSAR425899-2.572023-09-0610.1073/pnas.2303696120
8JIPB1PeptideGlucagonGLP-1Homo sapiensMEDI0382-chim(NtGi1-Gs)/β1/γ22.852023-09-0610.1073/pnas.2303696120
8JIP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensMEDI0382-2.852023-09-0610.1073/pnas.2303696120
9IVGB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ232024-11-2710.1016/j.apsb.2024.09.002
9IVG (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-32024-11-2710.1016/j.apsb.2024.09.002
9J1PB1PeptideGlucagonGLP-1Homo sapiensg1:Ox-chim(NtGi1-Gs)/β1/γ22.992025-02-2610.1021/jacs.4c12808
9J1P (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensg1:Ox-2.992025-02-2610.1021/jacs.4c12808
7X8SB1PeptideGlucagonGLP-1Homo sapiensWB4-24-Gs/β1/γ23.092022-06-2910.1073/pnas.2200155119
7X8S (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensWB4-24-3.092022-06-2910.1073/pnas.2200155119
7X8RB1PeptideGlucagonGLP-1Homo sapiensBOC5-Gs/β1/γ22.612022-06-2910.1073/pnas.2200155119
7X8R (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensBOC5-2.612022-06-2910.1073/pnas.2200155119
7S15B1PeptideGlucagonGLP-1Homo sapiensPubChem 134611223--3.82022-06-0810.1021/acs.jmedchem.1c01856
7RGPB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-chim(NtGi1-Gs)/β1/γ22.92022-04-1310.1073/pnas.2116506119
7RGP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-2.92022-04-1310.1073/pnas.2116506119
7RG9B1PeptideGlucagonGLP-1Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22022-04-1310.1073/pnas.2116506119
7RG9 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.22022-04-1310.1073/pnas.2116506119
7VBHB1PeptideGlucagonGLP-1Homo sapiensPeptide-20-Gs/β1/γ232022-04-0610.1038/s41467-022-28683-0
7VBH (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-20-32022-04-0610.1038/s41467-022-28683-0
7VBIB1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-Gs/β1/γ232022-03-0210.1038/s41467-022-28683-0
7VBI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-32022-03-0210.1038/s41467-022-28683-0
7FIMB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-Gs/β1/γ23.42022-03-0210.1038/s41467-022-28683-0
7FIM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-3.42022-03-0210.1038/s41467-022-28683-0
7LLYB1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-Gs/β1/γ23.32022-01-1210.1038/s41467-021-27760-0
7LLY (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-3.32022-01-1210.1038/s41467-021-27760-0
7LLLB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ23.72022-01-1210.1038/s41467-021-27760-0
7LLL (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-3.72022-01-1210.1038/s41467-021-27760-0
7S3IB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.512022-01-0510.1038/s41589-021-00945-w
7S3I (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.512022-01-0510.1038/s41589-021-00945-w
7S1MB1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-Gs/β1/γ22.412022-01-0510.1038/s41589-021-00945-w
7S1M (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-2.412022-01-0510.1038/s41589-021-00945-w
7RTBB1PeptideGlucagonGLP-1Homo sapiensPeptide-19-Gs/β1/γ22.142021-10-0610.1016/j.bbrc.2021.09.016
7RTB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-19-2.142021-10-0610.1016/j.bbrc.2021.09.016
7EVMB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ22.52021-08-1110.1038/s41467-021-24058-z
7EVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227382.52021-08-1110.1038/s41467-021-24058-z
7DURB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ23.32021-08-1110.1038/s41467-021-24058-z
7DUR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227383.32021-08-1110.1038/s41467-021-24058-z
7KI1B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-Gs/β1/γ22.52021-08-0410.1016/j.celrep.2021.109374
7KI1 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-2.52021-08-0410.1016/j.celrep.2021.109374
7KI0B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-Gs/β1/γ22.52021-08-0410.1016/j.celrep.2021.109374
7KI0 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-2.52021-08-0410.1016/j.celrep.2021.109374
7DUQB1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 156022738Gs/β1/γ22.52021-07-1410.1038/s41467-021-24058-z
7DUQ (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 1560227382.52021-07-1410.1038/s41467-021-24058-z
7E14B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 156022738Gs/β1/γ22.92021-07-0710.1038/s41467-021-24058-z
7E14 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 1560227382.92021-07-0710.1038/s41467-021-24058-z
7LCKB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--3.242021-01-2010.1016/j.str.2021.04.008
7LCJB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--2.822021-01-2010.1016/j.str.2021.04.008
7LCIB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.92021-01-2010.1016/j.str.2021.04.008
7LCI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.92021-01-2010.1016/j.str.2021.04.008
6XOXB1PeptideGlucagonGLP-1Homo sapiensOrforglipron-chim(NtGi1-Gs)/β1/γ23.12020-11-1810.1073/pnas.2014879117
6XOX (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipron-3.12020-11-1810.1073/pnas.2014879117
6X1AB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.52020-09-0910.1016/j.molcel.2020.09.020
6X1A (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.52020-09-0910.1016/j.molcel.2020.09.020
6X19B1PeptideGlucagonGLP-1Homo sapiensCHU-128-Gs/β1/γ22.12020-09-0910.1016/j.molcel.2020.09.020
6X19 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensCHU-128-2.12020-09-0910.1016/j.molcel.2020.09.020
6X18B1PeptideGlucagonGLP-1Homo sapiensGLP-1-Gs/β1/γ22.12020-09-0910.1016/j.molcel.2020.09.020
6X18 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1-2.12020-09-0910.1016/j.molcel.2020.09.020
7C2EB1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-Gs/β1/γ24.22020-08-2610.1038/s41422-020-0384-8
7C2E (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-4.22020-08-2610.1038/s41422-020-0384-8
6VCBB1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN3160440Gs/β1/γ23.32020-07-2210.1038/s41589-020-0589-7
6VCB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN31604403.32020-07-2210.1038/s41589-020-0589-7
6LN2B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-3.22020-03-1810.1038/s41467-020-14934-5
6ORVB1PeptideGlucagonGLP-1Homo sapiens-TT-OAD2Gs/β1/γ232020-01-0810.1038/s41586-019-1902-z
6ORV (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-TT-OAD232020-01-0810.1038/s41586-019-1902-z
6KK7B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-3.12019-11-1310.1107/S2052252519013496
6KK1B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-2.82019-11-1310.1107/S2052252519013496
6KJVB1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-2.82019-11-1310.1107/S2052252519013496
6B3JB1PeptideGlucagonGLP-1Homo sapiensExendin-P5-Gs/β1/γ23.32018-02-2110.1038/nature25773
6B3J (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-P5-3.32018-02-2110.1038/nature25773
5NX2B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)--3.72017-06-1410.1038/nature22800
5VEWB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.72017-05-2410.1038/nature22378
5VAIB1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-Gs/β1/γ24.12017-05-2410.1038/nature22394
5VAI (No Gprot) B1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-4.12017-05-2410.1038/nature22394
5VEXB1PeptideGlucagonGLP-1Homo sapiens-NNC0640-32017-05-1710.1038/nature22378




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7FIM.zip



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