Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1NT 7.00151024
21x35 7.255406
31x39 7.05938407
42x38 4.42125407
52x40 3.095408
62x42 5.7115507
72x44 3.79187405
82x50 7.0885519
92x53 6.9035516
102x60 9.425417
112x64 8.0375425
12E1x50 7.88042619
13E1x52 7.812506
143x32 6.76937416
153x35 5.8505518
163x46 5.105439
173x51 6.24875458
18I2x54 2.07687404
194x38 2.35125407
204x46 3.89407
214x50 4.335449
224x64 8.20875424
23E2 16.21711224
245x44 3.5775404
255x58 5.1085509
266x48 6.9175518
276x51 5.997516
286x62 5.80438423
29E3 4.40812401
307x30 3.51938404
317x42 5.74667617
327x45 5.4375409
337x46 6.9325519
347x49 6.1905519
357x52 4.6725468
367x53 5.58625439
377x54 4.16188407
388x50 4.68375408
39Lig 8.58751310
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
11x35 1x39 11.23996.045YesYes067
21x39 7x39 15.14868.5475YesNo075
31x42 7x39 11.833.98NoNo075
41x43 1x47 14.36756.54NoNo066
51x47 2x51 19.10235.94NoNo067
61x50 2x51 21.45933.09NoNo097
71x50 2x50 28.48868.0775NoYes099
82x50 7x46 37.715211.2125YesYes199
92x53 7x46 36.23999.9525YesYes169
102x53 3x32 18.17553.965YesYes166
112x63 Lig 38.03463.4475NoYes050
122x63 E1 24.83349.18NoNo054
13E1 NT 19.71674.3575NoYes244
142x53 7x42 10.33059.045YesYes167
157x42 Lig 17.02654.845YesYes170
163x35 7x46 13.39216.13YesYes189
173x35 7x42 11.55583.4875YesYes187
181x57 7x54 28.21096.745NoYes077
191x53 7x54 35.52834.44NoYes097
201x53 7x53 38.35055.9925NoYes099
216x40 7x53 98.27135.3475NoYes089
226x40 7x49 1004.25NoYes089
237x45 7x49 48.09439.195YesYes099
246x44 7x45 41.00944.5325NoYes099
256x44 6x48 78.79417.5175NoYes098
266x48 Lig 75.3683.465YesYes180
273x43 7x49 38.18384.25NoYes089
283x43 6x44 38.26373.98NoNo089
291x57 2x44 13.56576.6075NoYes075
302x38 2x42 23.47263.205YesYes077
312x42 4x46 24.84033.705YesYes077
322x45 4x46 25.09728.465NoYes097
332x45 3x42 22.38618.02NoNo497
343x42 4x49 26.395410.66NoNo077
353x41 4x49 26.80514.135NoNo057
363x37 3x41 28.54076.63NoNo075
373x37 Lig 29.90845.545NoYes070
383x46 7x53 70.50135.985YesYes399
392x42 4x45 10.28196.5YesNo075
402x60 E1x50 25.19797.5YesYes179
412x63 E1x50 18.22068.925NoYes059
422x60 Lig 16.915420.705YesYes170
432x59 E1x52 10.94839.44NoYes066
44E1x50 E1x52 32.692313.0275YesYes096
453x24 E1x52 10.95535.86NoYes056
464x65 E2x52 34.11217.19NoNo054
47E2 E2x52 22.129311.4225YesNo244
485x49 5x53 10.43113.4525NoNo067
493x44 5x53 16.90164.385NoNo077
503x44 5x54 18.58864.56NoNo078
513x47 5x54 20.26878.9025NoNo098
523x47 5x58 54.78345.725NoYes099
535x58 6x37 63.4653.4525YesNo097
543x46 6x37 64.854.995YesNo097
553x51 5x57 33.15754.9175YesNo087
563x47 5x57 34.76813.35NoNo097
573x51 3x55 23.844111.725YesNo587
583x54 5x64 19.27593.175NoNo085
593x55 5x64 22.29943.315NoNo075
603x54 5x61 17.59589.7275NoNo088
616x51 6x52 36.79885.09YesNo068
626x51 Lig 40.52695.93YesYes160
635x47 6x52 11.850915.22NoNo088
645x61 6x34 15.90534.3975NoNo086
653x50 8x50 16.78711.225NoYes098
663x49 3x50 18.74483.275NoNo089
672x38 3x49 20.61584.745YesNo078
685x44 6x56 17.44312.415YesNo045
695x44 6x52 24.54537.435YesNo048
706x56 6x60 16.00257.915NoNo053
716x60 E3 14.5559.045NoYes031
728x50 8x54 10.84422.435YesNo087
732x40 I1 10.47285.355YesNo080
741x57 2x40 14.52373.1425NoYes078
753x27 3x28 10.97262.62NoNo066
765x35 5x39 15.78032.35NoNo015
775x39 5x42 13.15262.5725NoNo053
784x60 5x42 10.51791.675NoNo063
791x39 Lig 22.70557.4925YesYes070
804x65 Lig 36.198318.89NoYes050
814x64 E2x52 10.76449.22YesNo244
822x50 7x49 16.10326.395YesYes199
837x45 7x46 10.41034.0875YesYes099
842x42 3x46 19.90774.8325YesYes079
852x60 3x32 10.1434.6425YesYes176
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
1x351x396.0450YesYes6721
1x392x576.15250YesNo7812
1x397x398.54750YesNo7512
1x39Lig7.49250YesYes7010
2x533x323.9651YesYes6621
2x533x358.021YesYes6822
2x537x429.0451YesYes6721
2x60E1x507.51YesYes7912
2x603x324.64251YesYes7611
2x60Lig20.7051YesYes7010
2x63E19.180NoNo5412
2x63E1x508.9250NoYes5912
2x63Lig3.44750NoYes5010
3x294x657.66750NoNo5521
3x327x424.961YesYes6711
3x32Lig13.511YesYes6010
3x33Lig9.850NoYes4010
3x357x423.48751YesYes8721
3x366x4810.9051NoYes7811
3x36Lig6.05251NoYes7010
3x373x416.630NoNo7512
3x374x569.9550NoNo7512
3x37Lig5.5450NoYes7010
4x65E2x527.190NoNo5412
4x65Lig18.890NoYes5010
6x446x487.51750NoYes9821
6x487x419.08251YesNo8812
6x487x423.61751YesYes8711
6x516x557.92751YesNo6612
6x517x375.14251YesNo6712
6x517x385.8951YesNo6611
7x38Lig7.6151NoYes6010
7x42Lig4.8451YesYes7010
2x562x604.85250NoYes7721
3x334x614.35250NoNo4412
2x533x363.5351YesNo6721
2x577x428.5250NoYes8721
5x43Lig4.290NoYes5010
6x48Lig3.4651YesYes8010
6x516x525.091YesNo6812
6x51Lig5.931YesYes6010
3x334x573.230NoNo4712
5x405x431.30750NoNo5521

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
92.86Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
92.86Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
75.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
66.67Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
64.71Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
64.71Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
64.71Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
64.71Consensusendothelin_offOrthosteric Ligandetb_off
64.71Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
62.50Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
61.11Single7SK9CCX6627SK9-ACKR3-CCX662
58.82Single6ZG4HTL00099366ZG4-M1-HTL0009936
58.82Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
57.14Single6AKXA4R6AKX-CCR5-A4R
57.14Single6AKYMaraviroc6AKY-CCR5-Maraviroc
57.14Consensusalpha1_onOrthosteric Ligandalpha1a_on
57.14Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
56.25Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
53.33Single4MBSMaraviroc4MBS-CCR5-Maraviroc
53.33Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
53.33Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
53.33Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.33Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.33Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
52.94Single4U15Tiotropium4U15-M3-Tiotropium
52.94Single5X93K-87945X93-ETB-K-8794
52.94Single6OL9Tiotropium6OL9-M5-Tiotropium
52.94Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
52.94Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
52.94Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
52.94Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
52.94Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
52.94Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
52.63Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
52.63Single8X5YAstemizole8X5Y-H1-Astemizole
50.00Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
50.00Single3NY8ICI 118-5513NY8-β2-ICI 118-551
50.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
50.00Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
50.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
50.00Single5CXVTiotropium5CXV-M1-Tiotropium
50.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
50.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
50.00Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
50.00Single6TOTLemborexant6TOT-OX1-Lemborexant
50.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
50.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
50.00Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
50.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
50.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
50.00Single7YITNalfurafine7YIT-κ-Nalfurafine
50.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
50.00Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
50.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
50.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
50.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
50.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
50.00Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
50.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
50.00Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
50.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
50.00Consensusblt_onOrthosteric Ligandblt1_on
50.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
50.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
50.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
50.00Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
50.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
50.00Consensusleuko_onOrthosteric Ligandblt_on
50.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
50.00Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
50.00Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
50.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
50.00Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
50.00Consensustar_onOrthosteric Ligandta1_on
47.83Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
47.37Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
47.37Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
47.37Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.37Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
47.37Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
47.06Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
47.06Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
47.06Single5C1MBU725C1M-μ-BU72
47.06Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
47.06Single5WIUNemonapride5WIU-D4-Nemonapride
47.06Single5WIVNemonapride5WIV-D4-Nemonapride-Na
47.06Single5WQCEMPA5WQC-OX2-EMPA
47.06Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
47.06Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
47.06Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
47.06Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
47.06Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
47.06Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
47.06Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
47.06Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
47.06Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
47.06Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
47.06Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
47.06Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
47.06Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
47.06Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
47.06Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.06Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
47.06Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.06Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
46.67Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
46.67Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
46.67Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
46.67Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
46.67Single6B73PubChem 1319551386B73-κ-PubChem 131955138
46.67Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
46.67Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
46.67Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
46.67Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
46.67Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
46.67Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
46.67Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
46.67Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
46.67Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67Single8GGVEpinephrine8GGV-β2-Epinephrine
46.67Single8GGWEpinephrine8GGW-β2-Epinephrine
46.67Single8GGXEpinephrine8GGX-β2-Epinephrine
46.67Single8GH0Epinephrine8GH0-β2-Epinephrine
46.67Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
46.67Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
46.67Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
46.67Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
46.67Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
46.67Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.67Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.67Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
46.15Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
45.45Single6PT2KGCHM076PT2-δ-KGCHM07
45.45Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
44.44Single2YDVNECA2YDV-A2A-NECA
44.44Single4DJHJDTic4DJH-κ-JDTic
44.44Single4UHRCGS216804UHR-A2A-CGS21680
44.44Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
44.44Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
44.44Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
44.44Single5G53NECA5G53-A2A-NECA-Gs
44.44Single5V54Methiothepin5V54-5-HT1B-Methiothepin
44.44Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
44.44Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
44.44Single6TQ7SB-3348676TQ7-OX1-SB-334867
44.44Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
44.44Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
44.44Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
44.44Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
44.44Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
44.44Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
44.44Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
44.44Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
44.44Single8E0GBU728E0G-μ-BU72
44.44Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
44.44Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
44.44Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
44.44Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
44.44Consensus5ht1_offOrthosteric Ligand5ht1b_off
44.44Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
44.44Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
44.44Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
44.44Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
44.44Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
44.44Consensushistamine_offOrthosteric Ligandh1_off
44.44Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
44.44Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
44.44Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
44.44Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
43.75Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
43.75Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
43.75Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
43.75Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
43.75Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
43.75Single4ZJCSB-6740424ZJC-OX1-SB-674042
43.75Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
43.75Single6PS4ICI 118-5516PS4-β2-ICI 118-551
43.75Single6TPGEMPA6TPG-OX2-EMPA
43.75Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
43.75Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
43.75Single6ZG9GSK10347026ZG9-M1-GSK1034702
43.75Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
43.75Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
43.75Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
43.75Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
43.75Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
43.75Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
43.75Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
43.75Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
43.75Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
43.75Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
43.75Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
43.75Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
43.75Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
43.75Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
43.75Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
43.75Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
43.75Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
43.75Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
43.75Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
43.75Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75Single8GGIEpinephrine8GGI-β2-Epinephrine
43.75Single8GGQEpinephrine8GGQ-β2-Epinephrine
43.75Single8GGTEpinephrine8GGT-β2-Epinephrine
43.75Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
43.75Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
43.75Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
43.75Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
43.75Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Consensus5ht5_onOrthosteric Ligand5ht5a_on
43.75Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
43.75Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
43.75Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
43.75Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
43.75Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
43.75Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
43.75Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
43.75Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
43.75Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
43.48Single7C61Ergotamine7C61-5-HT1B-Ergotamine
43.48Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
43.48Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
42.86Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
42.86Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
42.86Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
42.86Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
42.86Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
42.86Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
42.86Single8GGREpinephrine8GGR-β2-Epinephrine
42.86Single8GGZEpinephrine8GGZ-β2-Epinephrine
42.86Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
42.86Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.86Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
42.86Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
42.11Single4AMIBucindolol4AMI-β1-Bucindolol
42.11Single6A93Risperidone6A93-5-HT2A-Risperidone
42.11Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
42.11Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
42.11Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
42.11Single7DFPSpiperone7DFP-D2-Spiperone
42.11Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
42.11Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
42.11Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.11Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
42.11Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
42.11Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
42.11Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
42.11Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
42.11Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
42.11Consensusgs_steroidOrthosteric Ligandgs_bileacid
42.11Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
42.11Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
41.18Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
41.18Single2Y04Salbutamol2Y04-β1-Salbutamol
41.18Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
41.18Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
41.18Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
41.18Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
41.18Single4MQSIperoxo4MQS-M2-Iperoxo
41.18Single4U14Tiotropium4U14-M3-Tiotropium
41.18Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
41.18Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
41.18Single4YAYZD-71554YAY-AT1-ZD-7155
41.18Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
41.18Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
41.18Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
41.18Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
41.18Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
41.18Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
41.18Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
41.18Single6H7MSalbutamol6H7M-β1-Salbutamol
41.18Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
41.18Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
41.18Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
41.18Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
41.18Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
41.18Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
41.18Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
41.18Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
41.18Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
41.18Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
41.18Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
41.18Single7UL4Alvimopan7UL4-μ-Alvimopan
41.18Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
41.18Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
41.18Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
41.18Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
41.18Single7WC7Lisuride7WC7-5-HT2A-Lisuride
41.18Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
41.18Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
41.18Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
41.18Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
41.18Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
41.18Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8GGJEpinephrine8GGJ-β2-Epinephrine
41.18Single8GGNEpinephrine8GGN-β2-Epinephrine
41.18Single8GGOEpinephrine8GGO-β2-Epinephrine
41.18Single8GGUEpinephrine8GGU-β2-Epinephrine
41.18Single8JJOAlprenolol8JJO-β2-Alprenolol
41.18Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
41.18Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
41.18Single8X64Desloratadine8X64-H1-Desloratadine
41.18Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
41.18Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
41.18Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
41.18Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
41.18Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
41.18Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
41.18Consensushistamine_onOrthosteric Ligandh1_on h4_on
41.18Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
40.91Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
40.91Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
40.91Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
40.91Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
40.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
40.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
40.00Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
40.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
40.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
40.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
40.00Single6H7LDobutamine6H7L-β1-Dobutamine
40.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
40.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
40.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
40.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
40.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
40.00Single7SRQLSD7SRQ-5-HT2B-LSD
40.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
40.00Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
40.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
40.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
40.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
40.00Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8GGSEpinephrine8GGS-β2-Epinephrine
40.00Single8GGYEpinephrine8GGY-β2-Epinephrine
40.00Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
40.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
40.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
40.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
40.00Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
40.00Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
40.00Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
40.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
40.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
40.00Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
40.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
40.00Consensusorexin_onOrthosteric Ligandox2_on
40.00Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
40.00Consensussteroid_onOrthosteric Ligandbileacid_on
39.13Consensusangiotensin_onOrthosteric Ligandat1_on
39.13Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
38.89Single2Y00Dobutamine2Y00-β1-Dobutamine
38.89Single2Y03Isoprenaline2Y03-β1-Isoprenaline
38.89Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
38.89Single6D26Fevipiprant6D26-DP2-Fevipiprant
38.89Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
38.89Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
38.89Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
38.89Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
38.89Single6PS6Timolol6PS6-β2-Timolol
38.89Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
38.89Single6TP6Filorexant6TP6-OX1-Filorexant
38.89Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
38.89Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
38.89Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
38.89Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
38.89Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
38.89Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
38.89Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
38.89Single7WC6LSD7WC6-5-HT2A-LSD
38.89Single7XKAEpinephrine7XKA-β2-Epinephrine
38.89Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
38.89Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
38.89Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
38.89Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
38.89Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
38.89Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
38.89Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
38.89Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
38.89Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
38.89Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
38.46Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
38.46Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
38.10Single3NY9PubChem 9131033NY9-β2-PubChem 913103
38.10Single4UG2CGS216804UG2-A2A-CGS21680
38.10Single5ZTYAM102575ZTY-CB2-AM10257
38.10Single6PT3DPI-2876PT3-δ-DPI-287
38.10Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
38.10Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
38.10Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
38.10Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
38.10Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
38.10Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
38.10Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
37.50Single5DHHSB-6121115DHH-NOP-SB-612111
37.50Single5WS3EMPA5WS3-OX2-EMPA
37.50Single6KUXRS-799486KUX-α2a-RS-79948
37.50Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
37.50Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
37.50Single6TODEMPA6TOD-OX1-EMPA-Na
37.50Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
37.50Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
37.50Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
37.50Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
37.50Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
37.50Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
37.50Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
37.50Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
37.50Single7XRRLemborexant7XRR-OX2-Lemborexant
37.50Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
37.50Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
37.50Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
37.50Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
37.50Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8IHKAcifran8IHK-HCA3-Acifran
37.50Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Single8IWESpermidine8IWE-TAAR9-Spermidine
37.50Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
37.50Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
37.50Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
37.50Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
37.50Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
37.50Consensusgt_class-aOrthosteric Ligandgt_opsin
37.50Consensusgt_opsinOrthosteric Ligandgt_sensory
37.50Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
37.50Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
37.50Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
37.50Consensusorexin_offOrthosteric Ligandox2_off ox1_off
36.84Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
36.84Single4RWADIPP-NH24RWA-δ-DIPP-NH2
36.84Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
36.84Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
36.84Single6H7JIsoprenaline6H7J-β1-Isoprenaline
36.84Single6J21Aprepitant6J21-NK1-Aprepitant
36.84Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
36.84Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
36.84Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
36.84Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
36.84Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
36.84Single7TUYGSK682753A7TUY-GPR183-GSK682753A
36.84Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
36.84Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
36.84Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
36.84Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
36.84Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
36.84Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
36.84Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
36.84Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
36.84Consensusa2_onOrthosteric Liganda2a_on a2b_on
36.84Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
36.84Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
36.84Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
36.36Single4IARErgotamine4IAR-5-HT1B-Ergotamine
36.36Consensussst_onOrthosteric Ligandsst2_on sst4_on
35.71Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
35.71Single6TQ9SB-4081246TQ9-OX1-SB-408124
35.71Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
35.71Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
35.71Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
35.71Consensussensory_onOrthosteric Ligandopsin_on
35.29Single2YDOAdenosine2YDO-A2A-Adenosine
35.29Single3RZECidoxepin3RZE-H1-Cidoxepin
35.29Single6A94Zotepine6A94-5-HT2A-Zotepine
35.29Single6IQLL7458706IQL-D4-L745870
35.29Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
35.29Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
35.29Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
35.29Single6TPNHTL66416TPN-OX2-HTL6641
35.29Single6VI4JDTic6VI4-κ-JDTic
35.29Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
35.29Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
35.29Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
35.29Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
35.29Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
35.29Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
35.29Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
35.29Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
35.29Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8GGKEpinephrine8GGK-β2-Epinephrine
35.29Single8GGMEpinephrine8GGM-β2-Epinephrine
35.29Single8GGPEpinephrine8GGP-β2-Epinephrine
35.29Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
35.29Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
35.29Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
35.29Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
35.29Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
35.29Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
35.29Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
35.29Consensussensory_offOrthosteric Ligandopsin_off
35.00Single4LDEBI1671074LDE-β2-BI167107
35.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
35.00Single6CM4Risperidone6CM4-D2-Risperidone
35.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
35.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
35.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
35.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
35.00Single7K15MKD0467K15-BLT1-MKD046-Na
35.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
35.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
35.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
35.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
35.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
35.00Single8JJ8Formoterol8JJ8-β2-Formoterol
35.00Single8JJLOlodaterol8JJL-β2-Olodaterol
35.00Single8JWZAB9288JWZ-A2A-AB928-Na
35.00Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
35.00Consensusblt_offOrthosteric Ligandblt1_off
35.00Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
35.00Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
35.00Consensusdp_offOrthosteric Liganddp2_off
35.00Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
35.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
35.00Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
34.78Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
34.78Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
34.78Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
33.33Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
33.33Single2Y01Dobutamine2Y01-β1-Dobutamine
33.33Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
33.33Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
33.33Single4DAJTiotropium4DAJ-M3-Tiotropium
33.33Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
33.33Single5DSGTiotropium5DSG-M4-Tiotropium
33.33Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
33.33Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
33.33Single5WF5UK-4320975WF5-A2A-UK-432097
33.33Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
33.33Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
33.33Single6DRXLisuride6DRX-5-HT2B-Lisuride
33.33Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
33.33Single6IBLArformoterol6IBL-β1-Arformoterol
33.33Single6K1QIRL25006K1Q-ETB-IRL2500
33.33Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
33.33Single6PS1Timolol6PS1-β2-Timolol
33.33Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
33.33Single7BU7BI1671077BU7-β1-BI167107
33.33Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
33.33Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
33.33Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
33.33Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
33.33Single7UM4AS26747237UM4-5-HT5A-AS2674723
33.33Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
33.33Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
33.33Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
33.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
33.33Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
33.33Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
33.33Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
33.33Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
33.33Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
33.33Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
33.33Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
33.33Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
33.33Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
33.33Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
33.33Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
33.33Single8K5DGSK2560738K5D-HCA2-GSK256073
33.33Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
33.33Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8X63Mepyramine8X63-H1-Mepyramine
33.33Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
33.33Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
33.33Consensusadenosine_onOrthosteric Liganda1_on a2_on
33.33Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
33.33Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Consensusgi_hcarOrthosteric Ligandgi_hca
33.33Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
33.33Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
33.33Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
33.33Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
33.33Consensusnucleotide_onOrthosteric Ligandadenosine_on
33.33Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
33.33Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
32.14Single6IGLIRL16206IGL-ETB-IRL1620
32.14Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
32.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
32.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
32.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
32.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
31.82Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
31.82Single7XN9L-054,5227XN9-SST2-L-054,522
31.82Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
31.82Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
31.82Consensuslpl_offOrthosteric Ligands1p_off lpa_off
31.82Consensuslpl_onOrthosteric Ligands1p_on lpa_on
31.58Single5CGCHTL142425CGC-mGlu5-HTL14242
31.58Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
31.58Single5TVNLSD5TVN-5-HT2B-LSD
31.58Single5XPRBosentan5XPR-ETB-Bosentan
31.58Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
31.58Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
31.58Single6E67BI1671076E67-β2-BI167107-Gs (fused)
31.58Single6LUQHaloperidol6LUQ-D2-Haloperidol
31.58Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
31.58Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
31.58Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
31.58Single7C4SS1P7C4S-S1P3-S1P
31.58Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
31.58Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
31.58Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
31.58Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
31.58Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
31.58Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
31.58Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
31.58Single8EA0Iperoxo8EA0-M3-Iperoxo
31.58Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
31.58Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
31.58Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
31.58Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
31.58Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
31.58Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
31.58Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
31.58Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
31.58Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
31.25Single3PBLEticlopride3PBL-D3-Eticlopride
31.25Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
31.25Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
31.25Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
31.25Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
31.25Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
31.25Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
31.25Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
31.25Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
31.25Single8GH1Epinephrine8GH1-β2-Epinephrine
31.25Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
31.25Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
31.25Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
31.25Single8K5BNiacin8K5B-HCA2-Niacin
31.25Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
31.25Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
31.25Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
31.25Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
31.03Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
30.77Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
30.77Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
30.77Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
30.77Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single7QA8Peptide7QA8-STE2-Peptide
30.43Single7QA8Peptide7QA8-STE2-Peptide
30.43Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
30.43Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
30.43Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
30.43Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
30.43Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.43Consensusclass-d_offOrthosteric Ligandste2_off
30.43Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
30.43Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
30.43Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
30.00Single3P0GBI1671073P0G-β2-BI167107
30.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
30.00Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
30.00Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
30.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
30.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
30.00Single6WGTLSD6WGT-5-HT2A-LSD
30.00Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
30.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
30.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
30.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
30.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
30.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
30.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
30.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
30.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
30.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
30.00Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
30.00Consensus5ht5_offOrthosteric Ligand5ht5a_off
30.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
30.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
30.00Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
30.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
30.00Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
29.63Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
29.63Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
29.41Single4S0VSuvorexant4S0V-OX2-Suvorexant
29.41Single6TPJSuvorexant6TPJ-OX2-Suvorexant
29.41Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
29.41Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
29.41Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
29.41Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
29.41Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
29.41Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
29.41Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
29.41Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
29.41Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
29.41Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
29.41Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.17Single3QAKUK-4320973QAK-A2A-UK-432097
29.17Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
29.17Single6HLOAprepitant6HLO-NK1-Aprepitant
29.17Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
29.17Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
28.57Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
28.57Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
28.57Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
28.57Single6HLPNetupitant6HLP-NK1-Netupitant
28.57Single6IIURamatroban6IIU-TP-Ramatroban
28.57Single6MXTSalmeterol6MXT-β2-Salmeterol
28.57Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
28.57Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
28.57Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
28.57Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
28.57Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
28.57Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
28.57Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
28.57Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
28.57Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
28.57Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
28.57Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
28.57Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
28.57Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
28.57Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
28.57Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single8WU1KCA8WU1-CB1-KCA-Arrestin1
28.57Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
28.57Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
28.57Consensusendothelin_onOrthosteric Ligandetb_on eta_on
28.57Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
28.57Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
28.57Consensusgi_class-fOther Ligandgi_frizzled
28.57Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
28.57Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
28.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
28.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
28.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
28.00Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
27.78Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
27.78Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
27.78Single6DS0Ly2660976DS0-5-HT2B-Ly266097
27.78Single6TP3Nemorexant6TP3-OX1-Nemorexant
27.78Single6TPKRetosiban6TPK-OT-Retosiban
27.78Single6V9SGTPL114036V9S-OX1-GTPL11403
27.78Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
27.78Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
27.78Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
27.78Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
27.78Single8GGLEpinephrine8GGL-β2-Epinephrine
27.78Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
27.78Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
27.78Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
27.78Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
27.78Single8K5CAcipimox8K5C-HCA2-Acipimox
27.78Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
27.78Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Consensushca_onOrthosteric Ligandhca2_on hca3_on
27.78Consensushcar_onOrthosteric Ligandhca_on
27.78Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
27.78Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
27.78Consensuss1p_offOrthosteric Ligands1p1_off
27.78Consensusvasopressin-ot_offOrthosteric Ligandot_off
27.59Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
27.59Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
27.59Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
27.27Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
27.27Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
27.27Single5CGDHTL142425CGD-mGlu5-HTL14242
27.27Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
27.27Single7EZCUKA7EZC-A2A-UKA
27.27Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
27.27Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
27.27Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
27.27Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
27.27Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
27.27Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
27.27Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
27.27Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.92Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
26.92Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single5GLHEndothelin-15GLH-ETB-Endothelin-1
26.67Single6IGKEndothelin-36IGK-ETB-Endothelin-3
26.67Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
26.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
26.67Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
26.67Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
26.32Single2Y02Carmoterol2Y02-β1-Carmoterol
26.32Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
26.32Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
26.32Single5TGZAM65385TGZ-CB1-AM6538
26.32Single6D27CAY104716D27-DP2-CAY10471
26.32Single6GPSMK08126GPS-CCR2-MK0812
26.32Single6IIVDaltroban6IIV-TP-Daltroban
26.32Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
26.32Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
26.32Single7F83PF-051904577F83-Ghrelin-PF-05190457
26.32Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
26.32Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
26.32Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
26.32Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
26.32Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
26.32Single8CU6LJ-45178CU6-A2A-LJ-4517
26.32Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
26.32Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
26.32Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
26.32Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
26.32Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
26.32Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
26.32Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
26.32Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
26.32Consensushcar_offOrthosteric Ligandsuccinate_off
26.32Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
26.32Consensustachykinin_offOrthosteric Ligandnk1_off
26.32Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
26.09Single5EE7MK08935EE7-Glucagon-MK0893
26.09Single5WF6UK-4320975WF6-A2A-UK-432097
26.09Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
26.09Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
26.09Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
26.09Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
26.09Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
26.09Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
26.09Consensusclass-d_offOrthosteric Ligandste2_off
26.09Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
26.09Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
26.09Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
25.93Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
25.93Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
25.93Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.93Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
25.93Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.81Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
25.81Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
25.00Single3OE6IT1t3OE6-CXCR4-IT1t
25.00Single3OE8IT1t3OE8-CXCR4-IT1t
25.00Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
25.00Single4XT1Fractalkine4XT1-US28-Fractalkine
25.00Single5N2SPSB365N2S-A1-PSB36
25.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
25.00Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
25.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
25.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
25.00Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
25.00Single6GPXMK08126GPX-CCR2-MK0812
25.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
25.00Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
25.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
25.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
25.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
25.00Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
25.00Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
25.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
25.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7SINNPS-21437SIN-CaS-NPS-2143
25.00Single7SINNPS-21437SIN-CaS-NPS-2143
25.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
25.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
25.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
25.00Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
25.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
25.00Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
25.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
25.00Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
25.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
25.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
25.00Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
25.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
25.00Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
25.00Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
25.00Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
25.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
25.00Consensusep_offOrthosteric Ligandep4_off
25.00Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
25.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
25.00Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
25.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
25.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
24.24Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
24.14Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
24.14Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
24.14Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
24.14Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
24.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
24.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
24.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
24.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
24.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
24.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
24.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
24.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
24.00Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
24.00Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
23.81Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
23.81Single5XR8AM8415XR8-CB1-AM841
23.81Single6E59L-7607356E59-NK1-L-760735
23.81Single6J20Aprepitant6J20-NK1-Aprepitant
23.81Single7B6WCyclazosin7B6W-α1b-Cyclazosin
23.81Single7EPENAM5637EPE-mGlu-NAM563
23.81Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
23.81Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
23.81Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
23.81Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
23.81Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
23.81Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
23.81Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
23.81Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
23.81Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
23.81Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
23.81Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
23.81Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
23.81Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
23.81Consensuslpa_offOrthosteric Ligandlpa1_off
23.81Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
23.81Consensusrelaxin_onOrthosteric Ligandrxfp4_on
23.81Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
23.53Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
23.53Single3OE9IT1t3OE9-CXCR4-IT1t
23.53Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
23.53Single6HLLCP999946HLL-NK1-CP99994
23.53Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
23.53Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
23.53Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
23.53Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
23.53Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
23.53Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
23.33Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
23.33Single8IY6Endothelin-18IY6-ETB-Endothelin-1
23.33Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
23.33Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.33Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
23.08Single6W25SHU91196W25-MC4-SHU9119-Ca
23.08Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
23.08Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
23.08Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
23.08Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
23.08Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
22.73Single5X33BIIL2605X33-BLT1-BIIL260
22.73Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
22.73Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
22.73Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
22.73Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
22.73Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.73Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
22.73Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
22.73Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
22.73Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
22.73Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
22.73Consensusclass-b2_onOrthosteric Ligandadgrg_on
22.73Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
22.73Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
22.73Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.73Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
22.73Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.22Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
22.22Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
22.22Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
22.22Single3ODUIT1t3ODU-CXCR4-IT1t
22.22Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
22.22Single5ZKQABT-4915ZKQ-PAF-ABT-491
22.22Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
22.22Single6ME2Ramelteon6ME2-MT1-Ramelteon
22.22Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
22.22Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
22.22Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
22.22Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
22.22Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.22Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
22.22Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
22.22Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
22.22Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
22.22Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
22.22Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
22.22Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
22.22Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
22.22Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
22.22Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
22.22Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
22.22Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
22.22Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
22.22Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
22.22Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
22.22Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
22.22Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
22.22Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
22.22Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
22.22Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
22.22Consensusclass-d_onOrthosteric Ligandste2_on
22.22Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
22.22Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
22.22Consensusgi_class-dOrthosteric Ligandgi_ste
22.22Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.22Consensusmglu_onOther Ligandmglu2_on mglu4_on
22.22Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
22.22Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
21.88Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
21.88Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
21.74Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
21.74Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
21.74Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.74Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
21.74Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
21.74Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
21.74Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
21.43Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
21.43Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
21.43Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
21.43Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
21.43Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
21.43Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
21.43Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
21.43Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
21.43Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
21.43Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
21.43Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
21.43Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
21.21Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
21.21Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
21.05Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
21.05Single6FFIMMPEP6FFI-mGlu5-MMPEP
21.05Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
21.05Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
21.05Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
21.05Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
21.05Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
21.05Single7T32ZM2413857T32-A2A-ZM241385
21.05Single7VODCariprazine7VOD-5-HT2A-Cariprazine
21.05Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
21.05Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
21.05Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
21.05Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
21.05Single8K2WAMG4878K2W-CXCR3-AMG487
21.05Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
20.83Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
20.83Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
20.83Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
20.83Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
20.83Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
20.83Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
20.83Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.83Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
20.69Single4XT3Fractalkine4XT3-US28-Fractalkine
20.69Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
20.69Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
20.69Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
20.69Consensusclass-d_onOrthosteric Ligandste2_on
20.69Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
20.69Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
20.69Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
20.59Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
20.59Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
20.59Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
20.51Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
20.00Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
20.00Single6FFHFenobam6FFH-mGlu5-Fenobam
20.00Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
20.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
20.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.00Single7F8XNN90567F8X-CCKA-NN9056
20.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
20.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
20.00Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
20.00Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
20.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
20.00Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
20.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
20.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
20.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
20.00Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
20.00Consensusgi_class-dOrthosteric Ligandgi_ste
20.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
20.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
20.00Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.00Consensusgo_class-b1Orthosteric Ligandgo_crf
20.00Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.00Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
20.00Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
20.00Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
19.35Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
19.35Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
19.35Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
19.35Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
19.23Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
19.23Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
19.23Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
19.23Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
19.23Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
19.23Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
19.05Single4NTJAZD12834NTJ-P2Y12-AZD1283
19.05Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
19.05Single5NM2ZM2413855NM2-A2A-ZM241385-Na
19.05Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
19.05Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
19.05Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
19.05Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
19.05Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
19.05Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
19.05Single7YXAONO-54306087YXA-S1P5-ONO-5430608
19.05Single8GNEKW-63568GNE-A2A-KW-6356-Na
19.05Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
18.75Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
18.75Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
18.75Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
18.52Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
18.52Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
18.52Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
18.52Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
18.52Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
18.52Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
18.18Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
18.18Single5XRAAM115425XRA-CB1-AM11542
18.18Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
18.18Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
18.18Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
18.18Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
18.18Single7P2L4YI7P2L-mGlu5-4YI
18.18Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
18.18Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
18.18Single7W41PD1762527W41-BB2-PD176252
18.18Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
18.18Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
18.18Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
18.18Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
18.18Consensusadenosine_offOrthosteric Liganda1_off a2_off
18.18Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
18.18Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
18.18Consensusbombesin_offOrthosteric Ligandbb2_off
18.18Consensuscck_onOrthosteric Ligandccka_on cckb_on
18.18Consensuschemerin_onOrthosteric Ligandcml1_on
18.18Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
18.18Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
18.18Consensusglp_onOrthosteric Ligandglp1_on glp2_on
18.18Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
18.18Consensuslpa_onOrthosteric Ligandlpa1_on
17.86Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
17.86Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.86Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.86Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.86Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
17.86Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
17.86Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
17.65Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
17.65Single3UZAGTPL92363UZA-A2A-GTPL9236
17.65Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
17.65Single6ME5Agomelatine6ME5-MT1-Agomelatine
17.65Single6ME9Ramelteon6ME9-MT2-Ramelteon
17.65Single7WC5Psilocin7WC5-5-HT2A-Psilocin
17.65Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
17.65Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
17.65Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
17.65Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
17.65Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
17.39Single4N4WSANT-14N4W-SMO-SANT-1
17.39Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
17.39Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
17.39Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
17.39Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
17.39Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
17.39Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
17.24Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
17.24Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
17.24Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
17.24Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
17.24Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
17.24Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
17.24Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
17.14Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
17.14Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
17.14Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
16.67Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
16.67Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
16.67Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
16.67Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
16.67Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
16.67Single6TP4ACT-4622066TP4-OX1-ACT-462206
16.67Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
16.67Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
16.67Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
16.67Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
16.67Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
16.67Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
16.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
16.67Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
16.67Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
16.67Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7SK3CXCL127SK3-ACKR3-CXCL12
16.67Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
16.67Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
16.67Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
16.67Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
16.67Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
16.67Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
16.67Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
16.67Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
16.67Consensusclass-t_onOrthosteric Ligandtaste2_on
16.67Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
16.67Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
16.67Consensusgo_class-b2Orthosteric Ligandgo_adhesion
16.67Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
16.67Consensusgs_class-tOrthosteric Ligandgs_taste
16.67Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
16.67Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
16.67Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensuspth_onOrthosteric Ligandpth1_on pth2_on
16.67Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
16.13Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.13Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
16.13Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
16.13Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
16.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
16.00Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
16.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
16.00Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusgs_class-b2Orthosteric Ligandgs_adgr
15.79Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
15.79Single5U09Taranabant5U09-CB1-Taranabant
15.79Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
15.79Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.79Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
15.79Single7F8ULintitript7F8U-CCKA-Lintitript
15.79Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.79Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.79Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
15.79Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
15.79Single8GNGIstradefylline8GNG-A2A-Istradefylline
15.79Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
15.79Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
15.79Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
15.79Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
15.79Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.79Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.79Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
15.62Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
15.62Single6LMLGlucagon6LML-Glucagon-Glucagon
15.62Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
15.62Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
15.62Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
15.62Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
15.62Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
15.62Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
15.62Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
15.38Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
15.38Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
15.38Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
15.38Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
15.38Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
15.38Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
15.15Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
15.15Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
15.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
15.00Single5JTBZM2413855JTB-A2A-ZM241385
15.00Single5K2BZM2413855K2B-A2A-ZM241385-Na
15.00Single6AQFZM2413856AQF-A2A-ZM241385
15.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
15.00Single6MH8ZM2413856MH8-A2A-ZM241385
15.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
15.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
15.00Single7AROLUF58337ARO-A2A-LUF5833-Na
15.00Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
15.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
15.00Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
15.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
15.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
15.00Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
15.00Consensusgnrh_offOrthosteric Ligandgnrh1_off
15.00Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
14.81Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
14.81Single7SK5CXCL127SK5-ACKR3-CXCL12
14.71Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
14.71Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
14.71Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
14.63Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
14.29Single3EMLZM2413853EML-A2A-ZM241385
14.29Single4EIYZM2413854EIY-A2A-ZM241385-Na
14.29Single5IU8Q274563475IU8-A2A-Q27456347-Na
14.29Single5K2AZM2413855K2A-A2A-ZM241385-Na
14.29Single5OLGZM2413855OLG-A2A-ZM241385-Na
14.29Single5UENDU1725UEN-A1-DU172
14.29Single5VRAZM2413855VRA-A2A-ZM241385-Na
14.29Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
14.29Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
14.29Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
14.29Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
14.29Single6S0LZM2413856S0L-A2A-ZM241385
14.29Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
14.29Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
14.29Single7PYRPSB-21157PYR-A2A-PSB-2115
14.29Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
14.29Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
14.29Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusa2_offOrthosteric Liganda2a_off
14.29Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
14.29Consensuscck_offOrthosteric Ligandccka_off
14.29Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
14.29Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
14.29Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
14.29Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
13.89Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
13.89Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
13.89Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
13.79Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
13.79Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
13.79Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
13.64Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
13.64Single5IUAQ274563485IUA-A2A-Q27456348-Na
13.64Single6LPLZM2413856LPL-A2A-ZM241385-Na
13.64Single6S0QZM2413856S0Q-A2A-ZM241385
13.64Single6WQAZM2413856WQA-A2A-ZM241385-Na
13.64Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
13.64Single7RM5ZM2413857RM5-A2A-ZM241385-Na
13.64Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
13.64Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
13.64Single8FYNZM2413858FYN-A2A-ZM241385-Na
13.64Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
13.64Single8QOTNanobody E8QOT-μ-Nanobody E
13.64Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.51Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
13.33Single5MZPCaffeine5MZP-A2A-Caffeine-Na
13.33Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.33Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
13.33Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single5TZR-5TZR-FFA1 (GPR40)-MK8666
13.04Single6OS1TRV0266OS1-AT1-TRV026
13.04Single7PX4PSB-21137PX4-A2A-PSB-2113
13.04Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
13.04Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
13.04Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
13.04Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
13.04Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
13.04Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
13.04Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
13.04Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
13.04Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
12.90Single6FJ3PTH6FJ3-PTH1-PTH
12.90Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
12.82Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
12.50Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
12.50Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
12.50Single6OS2TRV0266OS2-AT1-TRV026
12.50Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
12.50Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
12.50Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
12.50Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
12.50Single8PWNTheophylline8PWN-A2A-Theophylline
12.50Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
12.50Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
12.50Consensuschemokine_offOrthosteric Ligandcxcr_off
12.50Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
12.50Consensuscxcr_offOrthosteric Ligandcxcr4_off
12.50Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
12.50Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
12.50Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.12Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
12.12Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
12.12Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
12.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
12.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
12.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
12.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
12.00Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
12.00Consensuscyslt_offOrthosteric Ligandcyslt2_off
12.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Single3RFMCaffeine3RFM-A2A-Caffeine
11.76Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
11.76Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
11.76Single8A2OTheophylline8A2O-A2A-Theophylline-Na
11.76Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
11.54Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
11.43Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
11.11Single6LI0GTPL98046LI0-GPR52-GTPL9804
11.11Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
11.11Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
11.11Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
11.11Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
11.11Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
11.11Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
10.71Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
10.71Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Single5L7IVismodegib5L7I-SMO-Vismodegib
10.53Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
10.53Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
10.53Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
10.53Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
10.34Single3OE0CVX153OE0-CXCR4-CVX15
10.34Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
10.00Single3PWHZM2413853PWH-A2A-ZM241385
10.00Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
10.00Single5K2DZM2413855K2D-A2A-ZM241385
10.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
10.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
10.00Single6JZHZM2413856JZH-A2A-ZM241385-Na
10.00Single6PS7ZM2413856PS7-A2A-ZM241385-Na
10.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
10.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
10.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
9.76Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
9.68Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single3REYPubChem 56973REY-A2A-PubChem 5697
9.52Single5IU4ZM2413855IU4-A2A-ZM241385-Na
9.52Single5IUBQ274563445IUB-A2A-Q27456344-Na
9.52Single5K2CZM2413855K2C-A2A-ZM241385-Na
9.52Single5NLXZM2413855NLX-A2A-ZM241385-Na
9.52Single5NM4ZM2413855NM4-A2A-ZM241385-Na
9.52Single5UVIZM2413855UVI-A2A-ZM241385
9.52Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
9.52Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
9.52Single8IYXYL-3658IYX-GPR34-YL-365
9.52Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
9.52Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
9.52Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
9.38Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
9.38Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
9.38Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
9.09Single6LPJZM2413856LPJ-A2A-ZM241385-Na
9.09Single6LPKZM2413856LPK-A2A-ZM241385-Na
9.09Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
9.09Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
9.09Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.09Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.09Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
9.09Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
8.82Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
8.82Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
8.70Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
8.70Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.70Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.70Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
8.70Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
8.33Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
8.33Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
8.33Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
8.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
8.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
8.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
8.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
8.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
8.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
8.00Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.89Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
7.69Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
7.69Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
7.69Consensusclass-c_offOther Ligandgabab_off mglu_off
7.50Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.41Single6KNMJN241-96KNM-Apelin-JN241-9
7.41Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
7.41Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.41Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
7.41Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
7.41Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
7.41Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
7.41Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
7.14Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
6.90Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
6.90Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
6.90Single7SHEPI; PE7SHE-GPR158-PI; PE
6.90Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.90Consensussst_offOrthosteric Ligandsst2_off
6.67Single7XNACYN1548067XNA-SST2-CYN154806
6.67Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
6.67Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
6.67Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
6.45Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
6.45Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
6.25Single6W25Ca6W25-MC4-SHU9119-Ca
6.25Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
6.06Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
6.06Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
5.88Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
5.88Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.88Consensusclass-c_onOther Ligandgabab_on mglu_on
5.71Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
5.56Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
5.56Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
5.56Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
5.41Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.26Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
5.26Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
5.26Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
5.26Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
5.13Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.13Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
5.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
5.00Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
5.00Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.88Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.76Single4K5YCP-3763954K5Y-CRF1-CP-376395
4.76Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.76Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
4.76Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
4.76Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
4.76Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
4.76Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
4.76Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.65Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
4.55Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
4.55Single6ZINSR486926ZIN-NTS1-SR48692
4.55Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
4.55Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
4.55Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.55Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
4.55Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.35Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
4.35Single4Z9GCP-3763954Z9G-CRF1-CP-376395
4.35Single5T04Neurotensin5T04-NTS1-Neurotensin
4.35Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
4.35Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
4.35Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
4.35Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
4.35Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
4.35Single8GTIBMK-C2058GTI-CRF1-BMK-C205
4.35Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
4.35Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
4.17Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
4.17Single6Z4SSR486926Z4S-NTS1-SR48692
4.17Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
4.17Single8GTGBMK-I1528GTG-CRF1-BMK-I152
4.00Single5V56TC1145V56-SMO-TC114
4.00Single5V57TC1145V57-SMO-TC114
4.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
4.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
4.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
4.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
4.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.85Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
3.85Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
3.85Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
3.85Single6YVRNTS8-136YVR-NTS1-NTS8-13
3.85Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
3.85Single7SHEPI; PE7SHE-GPR158-PI; PE
3.85Single8GTMBMK-C2038GTM-CRF1-BMK-C203
3.85Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
3.85Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
3.85Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
3.85Consensusnts_offOrthosteric Ligandnts1_off
3.85Consensusnts_onOrthosteric Ligandnts1_on
3.70Single4BUONeurotensin4BUO-NTS1-Neurotensin
3.70Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
3.70Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
3.70Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
3.45Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
3.45Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
3.33Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.78Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
2.70Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
2.70Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2

Consensus Members
Id Members
at1_off 4YAY-AT1-ZD-7155
4ZUD-AT1-Olmesartan
at2_off 7JNI-AT2-Olodanrigan
Net Summary
Imin 3.4225
Number of Linked Nodes 276
Number of Links 310
Number of Hubs 39
Number of Links mediated by Hubs 159
Number of Communities 7
Number of Nodes involved in Communities 45
Number of Links involved in Communities 60
Path Summary
Number Of Nodes in MetaPath 86
Number Of Links MetaPath 85
Number of Shortest Paths 65634
Length Of Smallest Path 3
Average Path Length 13.9001
Length of Longest Path 32
Minimum Path Strength 0.92
Average Path Strength 6.03463
Maximum Path Strength 16.2
Minimum Path Correlation 0.7
Average Path Correlation 0.908844
Maximum Path Correlation 0.985
Minimum % Of Corr. Nodes 3.33333
Average % Of Corr. Nodes 41.2918
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 44.3989
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
angiotensin_off_onangiotensin_offangiotensin_on
This network is also present in following consensuses:
IdComponents
peptide_offopioid_off
angiotensin_off
bombesin_off
cck_off
endothelin_off
ghrelin_off
npy_off
nts_off
orexin_off
vasopressin-ot_off
tachykinin_off
sst_off



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download angiotensin_off.zip



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