Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:E16 7.6625404
2A:A:L45 5.59754188
3A:A:S51 2.1275409
4A:A:T55 3.5625409
5A:A:F219 6.66754178
6A:A:H220 7.3054127
7A:A:F222 7.81254127
8A:A:Q227 6.5725479
9A:A:K233 5.614199
10A:A:I244 5.1475408
11A:A:Y253 9.23554
12A:A:R258 15.9465224
13A:A:N264 4.66409
14A:A:F273 4.18409
15A:A:W281 6.655405
16A:A:N292 6.15409
17A:A:Q294 6.73456
18A:A:Y318 6.7825456
19A:A:Y339 5.2575453
20A:A:R342 6.5075454
21A:A:F345 6.145408
22A:A:R356 5.175402
23A:A:Y358 5.18434
24A:A:Y360 6.66438
25A:A:T364 6.514139
26A:A:D368 5.3165139
27A:A:R374 7.1754134
28A:A:Q384 4.724536
29A:A:R385 8.4425435
30A:A:L388 2.83438
31A:A:Y391 4.2925404
32A:A:L393 2.746538
33B:B:I18 3.5675407
34B:B:R22 3.075466
35B:B:L51 8.305429
36B:B:H54 9509
37B:B:W63 4.69667627
38B:B:Q75 6.15509
39B:B:I81 3.24254257
40B:B:W82 9.546529
41B:B:N88 7.0225407
42B:B:K89 6.93629
43B:B:I93 5.4875407
44B:B:L95 3.6454268
45B:B:W99 5.625609
46B:B:Y105 3.8475406
47B:B:Y111 5.435404
48B:B:Y124 4.416266
49B:B:L126 3.16405
50B:B:E130 4.525153
51B:B:H142 6.64286779
52B:B:Y145 4.784508
53B:B:F151 3.42333609
54B:B:L152 4.2325403
55B:B:Q156 4.285405
56B:B:D163 7.64579
57B:B:L168 3.9175446
58B:B:W169 10.9175478
59B:B:H183 7.22749
60B:B:V187 4.99449
61B:B:L190 4.3405
62B:B:F199 6.235449
63B:B:D205 6.07449
64B:B:L210 6.175405
65B:B:W211 7.51143748
66B:B:E215 7.09254273
67B:B:Q220 7.752567
68B:B:F222 5.99468
69B:B:H225 9.598509
70B:B:I229 3.5775407
71B:B:I232 3.832568
72B:B:F234 4.085405
73B:B:F235 5.028577286
74B:B:F241 4.882566
75B:B:T243 4.835408
76B:B:R251 14.8825468
77B:B:F253 7.125466
78B:B:D258 6.01567
79B:B:M262 4.8775484
80B:B:Y264 4.284585
81B:B:C271 5.4425405
82B:B:F278 5.2465287
83B:B:Y289 6.254587
84B:B:W297 8488
85B:B:D298 7.3854149
86B:B:R304 9.23485
87B:B:H311 6.696599
88B:B:T329 6.3525498
89B:B:W332 13.1575409
90B:B:D333 6.0675499
91B:B:L336 4.0475427
92B:B:K337 8.9475496
93B:B:W339 8.08333699
94B:B:N340 4.2429
95R:R:Y27 5.0475406
96R:R:M30 7.2625416
97R:R:N41 5.95409
98R:R:I48 3.77407
99R:R:F51 6.448505
100R:R:V68 3.174108
101R:R:D69 4.7954109
102R:R:L72 4.726517
103R:R:M77 3.818517
104R:R:Y79 8.245415
105R:R:R83 6.4775414
106R:R:W89 7.31833617
107R:R:F91 7.565416
108R:R:F95 7.346515
109R:R:H99 5.966515
110R:R:H113 5.5045108
111R:R:P128 4.088538
112R:R:Y131 5.36437
113R:R:M135 4.5875437
114R:R:I171 4.2754112
115R:R:Y172 12.1125403
116R:R:F185 6.0065111
117R:R:F186 4.21401
118R:R:F195 5.1675405
119R:R:P202 3.5375409
120R:R:Q220 7.1325436
121R:R:W264 5.5718
122R:R:F267 6.40333615
123R:R:F268 7.695617
124R:R:I281 6.8275402
125R:R:L289 3.42415
126R:R:Y294 8.418517
127R:R:Y304 4.29409
128R:R:F311 6.126509
129G:G:I9 5.296502
130G:G:R27 4.274568
131G:G:P60 7.1725429
132G:G:F61 4.9575828
133L:L:?1 9.5651010
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:L30 B:B:K89 24.19122.82NoYes059
2A:A:L30 B:B:K78 24.4284.23NoNo058
3B:B:D76 B:B:K78 25.371611.06NoNo098
4B:B:D76 B:B:L55 34.926.79NoNo096
5A:A:Y37 B:B:L55 36.0133.52NoNo046
6A:A:R42 A:A:Y37 36.230512.35NoNo094
7A:A:F222 A:A:R42 37.25265.34YesNo079
8A:A:F222 B:B:W99 39.296712.03YesYes079
9A:A:F238 B:B:W99 89.36868.02NoYes099
10A:A:F238 A:A:L44 89.18959.74NoNo099
11A:A:I244 A:A:L44 89.09948.56YesNo089
12A:A:I244 A:A:V287 88.2726.14YesNo086
13A:A:F273 A:A:V287 88.17823.93YesNo096
14A:A:F273 A:A:S349 81.75375.28YesNo097
15A:A:S349 A:A:W277 81.51977.41NoNo076
16A:A:H357 A:A:W277 81.402114.81NoNo076
17A:A:H357 A:A:S286 80.44812.79NoNo078
18A:A:I382 A:A:S286 80.32727.74NoNo068
19A:A:I382 A:A:Y360 80.20596.04NoYes068
20A:A:R385 A:A:Y360 76.14375.14YesYes358
21A:A:R385 R:R:Q220 74.9729.35YesYes356
22A:A:Q384 R:R:Q220 74.09857.68YesYes366
23A:A:Q384 R:R:P128 23.21917.9YesYes368
24R:R:D127 R:R:P128 18.19433.22NoYes058
25R:R:D127 R:R:R130 17.5978.34NoNo055
26A:A:V217 R:R:R130 17.29813.92NoNo055
27A:A:H41 A:A:V217 15.76222.77NoNo1765
28A:A:H41 A:A:T242 15.54625.48NoNo068
29A:A:L43 A:A:T242 15.33522.95NoNo078
30A:A:I245 A:A:L43 15.03122.85NoNo077
31A:A:I245 A:A:L45 14.4222.85NoYes078
32A:A:K53 A:A:L45 11.64158.46NoYes1898
33A:A:G47 A:A:S51 11.04471.86NoYes099
34A:A:G47 A:A:K53 11.35361.74NoNo099
35B:B:Q75 B:B:W99 99.75484.38YesYes099
36A:A:F273 A:A:F345 13.6763.22YesYes098
37A:A:F345 A:A:L289 11.38093.65YesNo089
38A:A:L289 A:A:P361 10.60911.64NoNo095
39A:A:P361 A:A:R342 10.085711.53NoYes554
40A:A:L388 A:A:Q384 57.04193.99YesYes386
41A:A:L388 A:A:L393 56.05392.77YesYes388
42A:A:L393 A:A:Y391 55.65723.52YesYes084
43A:A:Y391 R:R:R121 58.89575.14YesNo049
44B:B:K57 B:B:Q75 99.82638.14NoYes099
45B:B:K57 B:B:W332 99.839522.05NoYes099
46B:B:R314 B:B:W332 99.888619.99NoYes089
47B:B:D290 B:B:R314 99.921410.72NoNo068
48B:B:C271 B:B:D290 99.93169.34YesNo056
49B:B:C271 B:B:Y289 1002.69YesYes057
50B:B:I273 B:B:Y289 93.15486.04NoYes067
51B:B:G244 B:B:I273 99.63913.53NoNo056
52B:B:G244 B:B:S245 99.62111.86NoNo059
53B:B:H225 B:B:S245 44.127216.74YesNo099
54B:B:H225 B:B:T243 32.91995.48YesYes098
55B:B:I232 B:B:T243 45.15083.04YesYes088
56B:B:F241 B:B:I232 29.95543.77YesYes668
57B:B:F222 B:B:F241 58.20244.29YesYes686
58B:B:F222 B:B:R22 42.89184.28YesYes686
59B:B:I18 B:B:R22 32.04881.25YesYes076
60B:B:I18 G:G:L19 23.85114.28YesNo079
61B:B:K15 G:G:L19 22.93842.82NoNo069
62B:B:K15 B:B:R19 22.02534.95NoNo064
63B:B:N16 B:B:R19 19.28382.41NoNo014
64B:B:E12 B:B:N16 18.36935.26NoNo041
65B:B:E12 B:B:Q13 17.454311.47NoNo041
66B:B:Q13 B:B:Q9 16.53912.8NoNo013
67B:B:E10 B:B:Q9 15.623310.19NoNo083
68B:B:I229 B:B:S245 55.48544.64YesNo079
69B:B:I229 B:B:T243 32.70913.04YesYes078
70B:B:I229 B:B:S189 22.63273.1YesNo077
71B:B:I232 B:B:S189 22.51464.64YesNo087
72B:B:F253 B:B:T243 20.23577.78YesYes068
73B:B:F241 B:B:F253 30.06099.65YesYes666
74B:B:H225 B:B:R251 10.584321.44YesYes098
75B:B:F253 B:B:R251 10.19896.41YesYes668
76B:B:E10 B:B:L7 11.03043.98NoNo2388
77B:B:L7 G:G:I9 10.12141.43NoYes082
78B:B:D258 B:B:F222 12.33828.36YesYes678
79B:B:R22 G:G:R27 10.66263.2YesYes668
80B:B:D258 G:G:R27 10.76073.57YesYes678
81B:B:C25 G:G:R27 18.00526.96NoYes038
82B:B:C25 G:G:K29 16.20631.62NoNo034
83G:G:K29 G:G:K32 14.40712.87NoNo045
84B:B:M262 B:B:Y264 10.76784.79YesYes845
85B:B:L30 B:B:M262 10.31495.65NoYes054
86B:B:K89 B:B:W82 17.428511.6YesYes299
87B:B:L51 B:B:W82 15.427420.5YesYes299
88B:B:I338 G:G:F61 11.66233.77NoYes258
89B:B:D76 B:B:G77 10.85153.35NoNo098
90B:B:G77 B:B:L95 10.59433.42NoYes088
91B:B:I232 B:B:V200 33.41364.61YesNo686
92B:B:L210 B:B:V200 33.08624.47YesNo056
93B:B:L198 B:B:L210 32.32192.77NoYes035
94B:B:D212 B:B:L198 31.87299.5NoNo093
95B:B:D212 B:B:E215 30.96153.9NoYes2793
96B:B:E215 B:B:M217 30.073513.53YesNo033
97B:B:M217 G:G:Q18 29.62272.72NoNo039
98B:B:C218 G:G:Q18 28.724.58NoNo059
99B:B:C218 B:B:W211 28.26815.22NoYes058
100B:B:F180 B:B:W211 17.2377.02NoYes478
101B:B:F180 B:B:T178 16.79255.19NoNo474
102B:B:L168 B:B:T178 15.86644.42YesNo464
103B:B:L168 B:B:Q156 15.46645.32YesYes065
104B:B:D170 B:B:Q156 14.60755.22NoYes095
105B:B:D170 B:B:N155 13.20956.73NoNo093
106B:B:I171 B:B:N155 12.275611.33NoNo063
107B:B:I157 B:B:I171 11.80812.94NoNo076
108B:B:F151 B:B:I157 11.34027.54YesNo097
109R:R:I117 R:R:R121 52.18633.76NoNo099
110R:R:I117 R:R:Y304 48.54943.63NoYes099
111R:R:L114 R:R:Y304 29.59914.69NoYes099
112R:R:L114 R:R:N300 29.39195.49NoNo099
113R:R:D69 R:R:N300 28.91498.08YesNo1099
114R:R:D69 R:R:S297 27.37252.94YesNo099
115R:R:L72 R:R:S297 27.16084.5YesNo079
116R:R:L72 R:R:V76 15.88355.96YesNo077
117R:R:H99 R:R:V76 11.55838.3YesNo057
118R:R:V256 R:R:Y304 18.52035.05NoYes089
119R:R:V256 R:R:Y210 18.27623.79NoNo089
120R:R:M257 R:R:Y210 17.60254.79NoNo089
121R:R:M206 R:R:M257 17.1722.89NoNo098
122R:R:F260 R:R:M206 16.74417.46NoNo099
123R:R:F199 R:R:F260 15.83193.22NoNo089
124R:R:F199 R:R:F268 15.259518.22NoYes087
125B:B:I338 B:B:L51 14.76452.85NoYes259
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D103 R:R:V76 10.22 1 No No 6 7 1 2
R:R:M77 R:R:Y294 3.59 1 Yes Yes 7 7 2 1
R:R:S80 R:R:Y294 6.36 1 No Yes 6 7 2 1
R:R:I104 R:R:T100 3.04 0 No No 4 4 1 2
R:R:T100 R:R:V184 3.17 0 No No 4 4 2 1
R:R:D103 R:R:Y294 10.34 1 No Yes 6 7 1 1
L:L:?1 R:R:D103 15.19 1 Yes No 0 6 0 1
R:R:A155 R:R:I104 3.25 0 No No 6 4 2 1
L:L:?1 R:R:I104 10.27 1 Yes No 0 4 0 1
R:R:S107 R:R:W264 4.94 1 No Yes 6 8 1 1
L:L:?1 R:R:S107 13.21 1 Yes No 0 6 0 1
R:R:I111 R:R:W264 3.52 0 No Yes 8 8 2 1
R:R:F186 R:R:V184 5.24 0 Yes No 1 4 2 1
L:L:?1 R:R:V184 3.57 1 Yes No 0 4 0 1
R:R:F195 R:R:F268 6.43 0 Yes Yes 5 7 2 1
R:R:F268 R:R:S198 5.28 1 Yes No 7 6 1 1
L:L:?1 R:R:S198 7.2 1 Yes No 0 6 0 1
R:R:F199 R:R:F268 18.22 0 No Yes 8 7 2 1
R:R:F267 R:R:W264 3.01 1 Yes Yes 5 8 1 1
R:R:F268 R:R:W264 6.01 1 Yes Yes 7 8 1 1
R:R:G293 R:R:W264 4.22 0 No Yes 7 8 2 1
R:R:N296 R:R:W264 6.78 0 No Yes 9 8 2 1
L:L:?1 R:R:W264 10.02 1 Yes Yes 0 8 0 1
R:R:F267 R:R:F268 5.36 1 Yes Yes 5 7 1 1
R:R:F267 R:R:T271 7.78 1 Yes No 5 5 1 2
R:R:F267 R:R:L289 4.87 1 Yes Yes 5 5 1 2
R:R:F267 R:R:I290 3.77 1 Yes No 5 5 1 1
L:L:?1 R:R:F267 13.63 1 Yes Yes 0 5 0 1
L:L:?1 R:R:F268 4.87 1 Yes Yes 0 7 0 1
L:L:?1 R:R:I290 4.57 1 Yes No 0 5 0 1
R:R:W291 R:R:Y294 8.68 1 No Yes 4 7 2 1
L:L:?1 R:R:Y294 13.12 1 Yes Yes 0 7 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
90.91Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
90.91Single8JJOAlprenolol8JJO-β2-Alprenolol
90.91Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
90.91Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
90.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
83.33Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
83.33Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
83.33Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
83.33Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
83.33Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
81.82Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
81.82Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
81.82Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
81.82Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GGIEpinephrine8GGI-β2-Epinephrine
81.82Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
81.82Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
81.82Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
81.82Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
81.82Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
81.82Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
80.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
80.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
76.92Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
76.92Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
76.92Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
76.92Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
76.92Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
76.92Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
76.92Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
75.00Single3NY8ICI 118-5513NY8-β2-ICI 118-551
75.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
75.00Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
75.00Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
75.00Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
75.00Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
75.00Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
75.00Single6H7MSalbutamol6H7M-β1-Salbutamol
75.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
75.00Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
75.00Single6PS1Timolol6PS1-β2-Timolol
75.00Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
75.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
75.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
75.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
75.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
75.00Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
75.00Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
75.00Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
75.00Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GGJEpinephrine8GGJ-β2-Epinephrine
75.00Single8GGNEpinephrine8GGN-β2-Epinephrine
75.00Single8GGOEpinephrine8GGO-β2-Epinephrine
75.00Single8GGUEpinephrine8GGU-β2-Epinephrine
75.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
75.00Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
75.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
75.00Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
75.00Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
75.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
75.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
75.00Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
75.00Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
75.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
75.00Consensushistamine_onOrthosteric Ligandh1_on h4_on
75.00Consensustar_onOrthosteric Ligandta1_on
72.73Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
72.73Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
72.73Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GGVEpinephrine8GGV-β2-Epinephrine
72.73Single8GGWEpinephrine8GGW-β2-Epinephrine
72.73Single8GGXEpinephrine8GGX-β2-Epinephrine
72.73Single8GH0Epinephrine8GH0-β2-Epinephrine
72.73Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
72.73Consensusalpha1_onOrthosteric Ligandalpha1a_on
72.73Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
71.43Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
71.43Single4AMIBucindolol4AMI-β1-Bucindolol
71.43Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
71.43Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
71.43Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
71.43Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
70.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
69.23Single2Y03Isoprenaline2Y03-β1-Isoprenaline
69.23Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
69.23Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
69.23Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
69.23Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
69.23Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
69.23Single6PS6Timolol6PS6-β2-Timolol
69.23Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
69.23Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
69.23Single7XKAEpinephrine7XKA-β2-Epinephrine
69.23Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
69.23Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
69.23Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
69.23Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
69.23Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
69.23Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
69.23Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
69.23Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
69.23Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
69.23Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
69.23Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
66.67Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
66.67Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
66.67Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
66.67Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
66.67Single6A94Zotepine6A94-5-HT2A-Zotepine
66.67Single6PS4ICI 118-5516PS4-β2-ICI 118-551
66.67Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
66.67Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
66.67Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
66.67Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
66.67Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
66.67Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
66.67Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
66.67Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
66.67Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
66.67Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8GGKEpinephrine8GGK-β2-Epinephrine
66.67Single8GGMEpinephrine8GGM-β2-Epinephrine
66.67Single8GGPEpinephrine8GGP-β2-Epinephrine
66.67Single8GGQEpinephrine8GGQ-β2-Epinephrine
66.67Single8GGTEpinephrine8GGT-β2-Epinephrine
66.67Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
66.67Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
66.67Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
66.67Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
66.67Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
66.67Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
64.29Single2YDVNECA2YDV-A2A-NECA
64.29Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
64.29Single4U15Tiotropium4U15-M3-Tiotropium
64.29Single4UHRCGS216804UHR-A2A-CGS21680
64.29Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
64.29Single5G53NECA5G53-A2A-NECA-Gs
64.29Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
64.29Single6H7JIsoprenaline6H7J-β1-Isoprenaline
64.29Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
64.29Single6OL9Tiotropium6OL9-M5-Tiotropium
64.29Single6TQ7SB-3348676TQ7-OX1-SB-334867
64.29Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
64.29Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
64.29Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
64.29Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
64.29Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
64.29Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
64.29Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
64.29Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
64.29Consensushistamine_offOrthosteric Ligandh1_off
64.29Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
64.29Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
63.64Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
63.64Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
63.64Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
63.64Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GGSEpinephrine8GGS-β2-Epinephrine
63.64Single8GGYEpinephrine8GGY-β2-Epinephrine
63.64Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
63.64Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
63.64Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
63.64Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
62.50Single3NY9PubChem 9131033NY9-β2-PubChem 913103
62.50Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
61.54Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
61.54Single2Y04Salbutamol2Y04-β1-Salbutamol
61.54Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
61.54Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
61.54Single4DAJTiotropium4DAJ-M3-Tiotropium
61.54Single4MQSIperoxo4MQS-M2-Iperoxo
61.54Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
61.54Single4U14Tiotropium4U14-M3-Tiotropium
61.54Single5DSGTiotropium5DSG-M4-Tiotropium
61.54Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
61.54Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
61.54Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
61.54Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
61.54Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
61.54Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
61.54Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
61.54Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
61.54Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
61.54Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
61.54Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
61.54Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
61.54Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
61.54Single8X63Mepyramine8X63-H1-Mepyramine
61.54Single8X64Desloratadine8X64-H1-Desloratadine
61.54Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
61.54Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
61.54Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
61.54Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
61.54Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
61.54Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
61.54Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
60.00Single4LDEBI1671074LDE-β2-BI167107
60.00Single5CXVTiotropium5CXV-M1-Tiotropium
60.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
60.00Single6CM4Risperidone6CM4-D2-Risperidone
60.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
60.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
60.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
60.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
60.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
60.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
60.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
60.00Single8JJ8Formoterol8JJ8-β2-Formoterol
60.00Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
60.00Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
60.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
58.82Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
58.33Single6KUXRS-799486KUX-α2a-RS-79948
58.33Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
58.33Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
58.33Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
58.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
58.33Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
58.33Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
58.33Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
58.33Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
58.33Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
58.33Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
58.33Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
58.33Single8IWESpermidine8IWE-TAAR9-Spermidine
58.33Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
58.33Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
58.33Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
58.33Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
58.33Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
58.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
58.33Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
58.33Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
58.33Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
58.33Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
58.33Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
58.33Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
58.33Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
58.33Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
57.14Single5WIUNemonapride5WIU-D4-Nemonapride
57.14Single5WIVNemonapride5WIV-D4-Nemonapride-Na
57.14Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
57.14Single6E67BI1671076E67-β2-BI167107-Gs (fused)
57.14Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
57.14Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
57.14Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
57.14Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
57.14Single7WC6LSD7WC6-5-HT2A-LSD
57.14Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
57.14Single8EA0Iperoxo8EA0-M3-Iperoxo
57.14Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
57.14Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
57.14Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
57.14Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
57.14Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
57.14Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
57.14Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
57.14Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
57.14Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
56.25Single6H7LDobutamine6H7L-β1-Dobutamine
56.25Single6IBLArformoterol6IBL-β1-Arformoterol
56.25Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
56.25Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
56.25Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
56.25Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
56.25Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
56.25Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
54.55Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
54.55Single8GGREpinephrine8GGR-β2-Epinephrine
54.55Single8GGZEpinephrine8GGZ-β2-Epinephrine
54.55Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
54.55Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Single2YDOAdenosine2YDO-A2A-Adenosine
53.85Single3RZECidoxepin3RZE-H1-Cidoxepin
53.85Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
53.85Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
53.85Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
53.85Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
53.85Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
53.85Single8GGLEpinephrine8GGL-β2-Epinephrine
53.85Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
53.85Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
53.85Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
53.85Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
53.33Single3P0GBI1671073P0G-β2-BI167107
53.33Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
53.33Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
53.33Single5V54Methiothepin5V54-5-HT1B-Methiothepin
53.33Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
53.33Single6J20Aprepitant6J20-NK1-Aprepitant
53.33Single6J21Aprepitant6J21-NK1-Aprepitant
53.33Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
53.33Single6WGTLSD6WGT-5-HT2A-LSD
53.33Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
53.33Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
53.33Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
53.33Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
53.33Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
53.33Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
53.33Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
53.33Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
53.33Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
53.33Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
53.33Consensus5ht1_offOrthosteric Ligand5ht1b_off
53.33Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
53.33Consensus5ht5_offOrthosteric Ligand5ht5a_off
53.33Consensusa2_onOrthosteric Liganda2a_on a2b_on
53.33Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
53.33Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
52.94Single4UG2CGS216804UG2-A2A-CGS21680
52.94Single8X5YAstemizole8X5Y-H1-Astemizole
50.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
50.00Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
50.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
50.00Single2Y01Dobutamine2Y01-β1-Dobutamine
50.00Single2Y02Carmoterol2Y02-β1-Carmoterol
50.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
50.00Single3PBLEticlopride3PBL-D3-Eticlopride
50.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
50.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
50.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
50.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
50.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
50.00Single6A93Risperidone6A93-5-HT2A-Risperidone
50.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
50.00Single6MXTSalmeterol6MXT-β2-Salmeterol
50.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
50.00Single7BU7BI1671077BU7-β1-BI167107
50.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
50.00Single7DFPSpiperone7DFP-D2-Spiperone
50.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
50.00Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
50.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
50.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
50.00Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
50.00Single7SRQLSD7SRQ-5-HT2B-LSD
50.00Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
50.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
50.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
50.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
50.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
50.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
50.00Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00Single7YITNalfurafine7YIT-κ-Nalfurafine
50.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
50.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
50.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
50.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
50.00Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
50.00Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
50.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
50.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
50.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
50.00Consensusadenosine_onOrthosteric Liganda1_on a2_on
50.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
50.00Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
50.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
50.00Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
50.00Consensusnucleotide_onOrthosteric Ligandadenosine_on
50.00Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
50.00Consensustachykinin_offOrthosteric Ligandnk1_off
47.37Single3QAKUK-4320973QAK-A2A-UK-432097
47.37Single6HLOAprepitant6HLO-NK1-Aprepitant
47.06Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
47.06Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
47.06Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
47.06Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
47.06Single7EZCUKA7EZC-A2A-UKA
47.06Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
47.06Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
47.06Single7UM4AS26747237UM4-5-HT5A-AS2674723
47.06Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
47.06Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
47.06Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
47.06Consensusendothelin_offOrthosteric Ligandetb_off
47.06Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
46.67Single2Y00Dobutamine2Y00-β1-Dobutamine
46.67Single5C1MBU725C1M-μ-BU72
46.67Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
46.67Single5TVNLSD5TVN-5-HT2B-LSD
46.67Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
46.67Single6LUQHaloperidol6LUQ-D2-Haloperidol
46.67Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
46.67Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
46.67Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
46.67Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
46.67Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
46.67Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
46.67Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.67Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
46.67Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
46.67Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
46.67Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
46.15Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
46.15Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
46.15Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
46.15Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
46.15Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
46.15Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
46.15Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
46.15Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
45.45Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
45.45Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
45.45Consensussensory_onOrthosteric Ligandopsin_on
45.00Single5WF5UK-4320975WF5-A2A-UK-432097
44.44Single6PT3DPI-2876PT3-δ-DPI-287
44.44Single7SK9CCX6627SK9-ACKR3-CCX662
43.75Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
43.75Single4RWADIPP-NH24RWA-δ-DIPP-NH2
43.75Single5X93K-87945X93-ETB-K-8794
43.75Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
43.75Single6E59L-7607356E59-NK1-L-760735
43.75Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
43.75Single7B6WCyclazosin7B6W-α1b-Cyclazosin
43.75Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
43.75Single8E0GBU728E0G-μ-BU72
43.75Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
43.75Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
43.75Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
43.75Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
43.75Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
43.75Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
43.75Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
43.75Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
42.86Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
42.86Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
42.86Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
42.86Single6TPGEMPA6TPG-OX2-EMPA
42.86Single6TPNHTL66416TPN-OX2-HTL6641
42.86Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
42.86Single7C61Ergotamine7C61-5-HT1B-Ergotamine
42.86Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
42.86Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
42.86Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
42.86Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
42.86Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
42.86Single7T32ZM2413857T32-A2A-ZM241385
42.86Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
42.86Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
42.86Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.86Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
42.86Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
42.86Consensus5ht5_onOrthosteric Ligand5ht5a_on
42.86Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
42.86Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
42.86Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
42.86Consensussensory_offOrthosteric Ligandopsin_off
42.11Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
42.11Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
41.67Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
41.67Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
41.67Single3UZAGTPL92363UZA-A2A-GTPL9236
41.67Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
41.67Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
41.67Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
41.67Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
41.67Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
41.67Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
41.18Single6HLPNetupitant6HLP-NK1-Netupitant
41.18Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
41.18Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
41.18Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
41.18Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
41.18Single8JJLOlodaterol8JJL-β2-Olodaterol
41.18Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
41.18Single8JWZAB9288JWZ-A2A-AB928-Na
41.18Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
41.18Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
41.18Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
40.91Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
40.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
40.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
40.00Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
40.00Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
40.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
40.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
40.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
40.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
40.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
40.00Single7UL4Alvimopan7UL4-μ-Alvimopan
40.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
40.00Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
40.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
40.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
40.00Single8CU6LJ-45178CU6-A2A-LJ-4517
40.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
40.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
40.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
40.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
40.00Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
40.00Consensusgi_hcarOrthosteric Ligandgi_hca
40.00Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
38.89Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
38.89Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
38.89Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
38.89Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
38.89Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
38.89Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
38.46Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
38.46Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
38.46Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
38.46Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
38.46Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
38.46Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
38.46Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
38.46Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
38.46Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
38.46Single8GH1Epinephrine8GH1-β2-Epinephrine
38.46Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
38.46Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
38.46Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
38.46Single8K5BNiacin8K5B-HCA2-Niacin
38.10Single6PT2KGCHM076PT2-δ-KGCHM07
37.50Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
37.50Single5CGCHTL142425CGC-mGlu5-HTL14242
37.50Single5NM2ZM2413855NM2-A2A-ZM241385-Na
37.50Single5WQCEMPA5WQC-OX2-EMPA
37.50Single5XPRBosentan5XPR-ETB-Bosentan
37.50Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
37.50Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
37.50Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
37.50Single7SINNPS-21437SIN-CaS-NPS-2143
37.50Single7SINNPS-21437SIN-CaS-NPS-2143
37.50Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
37.50Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
37.50Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
37.50Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
37.50Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
36.84Single5WF6UK-4320975WF6-A2A-UK-432097
36.84Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
36.84Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
36.36Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
36.36Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
35.71Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
35.71Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
35.71Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
35.71Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
35.71Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
35.71Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
35.71Single5DHHSB-6121115DHH-NOP-SB-612111
35.71Single6AKXA4R6AKX-CCR5-A4R
35.71Single6AKYMaraviroc6AKY-CCR5-Maraviroc
35.71Single6B73PubChem 1319551386B73-κ-PubChem 131955138
35.71Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
35.71Single6ME2Ramelteon6ME2-MT1-Ramelteon
35.71Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
35.71Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
35.71Single6TODEMPA6TOD-OX1-EMPA-Na
35.71Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
35.71Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
35.71Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
35.71Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
35.71Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
35.71Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
35.71Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
35.71Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
35.71Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
35.71Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
35.71Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
35.71Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
35.71Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
35.71Consensusgt_class-aOrthosteric Ligandgt_opsin
35.71Consensusgt_opsinOrthosteric Ligandgt_sensory
35.71Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
35.71Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
35.29Single4DJHJDTic4DJH-κ-JDTic
35.29Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
35.29Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
35.29Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
35.29Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
35.29Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
35.29Single7W41PD1762527W41-BB2-PD176252
35.29Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
35.29Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
35.29Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
35.29Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
35.29Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
35.29Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
35.29Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
35.29Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
35.29Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
35.29Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
35.29Consensusadenosine_offOrthosteric Liganda1_off a2_off
35.29Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
35.29Consensusbombesin_offOrthosteric Ligandbb2_off
35.29Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
35.29Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
35.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
35.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
35.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.00Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
34.62Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
34.62Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
33.33Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
33.33Single4MBSMaraviroc4MBS-CCR5-Maraviroc
33.33Single4ZJCSB-6740424ZJC-OX1-SB-674042
33.33Single5IU7Q274563465IU7-A2A-Q27456346-Na
33.33Single5JTBZM2413855JTB-A2A-ZM241385
33.33Single5K2BZM2413855K2B-A2A-ZM241385-Na
33.33Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
33.33Single6AQFZM2413856AQF-A2A-ZM241385
33.33Single6DS0Ly2660976DS0-5-HT2B-Ly266097
33.33Single6IQLL7458706IQL-D4-L745870
33.33Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
33.33Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
33.33Single6V9SGTPL114036V9S-OX1-GTPL11403
33.33Single6VI4JDTic6VI4-κ-JDTic
33.33Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
33.33Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
33.33Single6ZG9GSK10347026ZG9-M1-GSK1034702
33.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
33.33Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
33.33Single7K15MKD0467K15-BLT1-MKD046-Na
33.33Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
33.33Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Single7VODCariprazine7VOD-5-HT2A-Cariprazine
33.33Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
33.33Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
33.33Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
33.33Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
33.33Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
33.33Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
33.33Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
33.33Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
33.33Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single8K5CAcipimox8K5C-HCA2-Acipimox
33.33Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
33.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
33.33Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
33.33Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
33.33Consensusblt_offOrthosteric Ligandblt1_off
33.33Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
33.33Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
33.33Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
33.33Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
33.33Consensusgs_steroidOrthosteric Ligandgs_bileacid
33.33Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
33.33Consensushca_onOrthosteric Ligandhca2_on hca3_on
33.33Consensushcar_onOrthosteric Ligandhca_on
33.33Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
33.33Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
33.33Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
33.33Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
33.33Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
32.00Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
31.82Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
31.82Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
31.58Single5CGDHTL142425CGD-mGlu5-HTL14242
31.58Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
31.58Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
31.58Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
31.58Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
31.58Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
31.58Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
31.58Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
31.58Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
31.58Consensussteroid_onOrthosteric Ligandbileacid_on
31.25Single3EMLZM2413853EML-A2A-ZM241385
31.25Single4EIYZM2413854EIY-A2A-ZM241385-Na
31.25Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
31.25Single4YAYZD-71554YAY-AT1-ZD-7155
31.25Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
31.25Single5IU8Q274563475IU8-A2A-Q27456347-Na
31.25Single5K2AZM2413855K2A-A2A-ZM241385-Na
31.25Single5OLGZM2413855OLG-A2A-ZM241385-Na
31.25Single5TGZAM65385TGZ-CB1-AM6538
31.25Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
31.25Single5VRAZM2413855VRA-A2A-ZM241385-Na
31.25Single6S0LZM2413856S0L-A2A-ZM241385
31.25Single6TOTLemborexant6TOT-OX1-Lemborexant
31.25Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
31.25Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
31.25Single7PYRPSB-21157PYR-A2A-PSB-2115
31.25Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
31.25Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
31.25Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
31.25Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
31.25Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.25Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
31.25Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
31.25Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
31.25Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
31.25Single8K5DGSK2560738K5D-HCA2-GSK256073
31.25Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
31.25Consensusa2_offOrthosteric Liganda2a_off
31.25Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
31.25Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.25Consensusblt_onOrthosteric Ligandblt1_on
31.25Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.25Consensusleuko_onOrthosteric Ligandblt_on
30.77Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
30.77Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
30.77Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
30.77Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
30.77Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
30.43Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
30.43Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
30.43Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
30.00Single5ZTYAM102575ZTY-CB2-AM10257
30.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single7XN9L-054,5227XN9-SST2-L-054,522
30.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
30.00Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
30.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
30.00Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
29.41Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
29.41Single5IUAQ274563485IUA-A2A-Q27456348-Na
29.41Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
29.41Single5N2SPSB365N2S-A1-PSB36
29.41Single6D26Fevipiprant6D26-DP2-Fevipiprant
29.41Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
29.41Single6LPLZM2413856LPL-A2A-ZM241385-Na
29.41Single6S0QZM2413856S0Q-A2A-ZM241385
29.41Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
29.41Single6TP6Filorexant6TP6-OX1-Filorexant
29.41Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
29.41Single6WQAZM2413856WQA-A2A-ZM241385-Na
29.41Single7C4SS1P7C4S-S1P3-S1P
29.41Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
29.41Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
29.41Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
29.41Single7RM5ZM2413857RM5-A2A-ZM241385-Na
29.41Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
29.41Single8FYNZM2413858FYN-A2A-ZM241385-Na
29.41Single8GNEKW-63568GNE-A2A-KW-6356-Na
29.41Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
29.41Single8QOTNanobody E8QOT-μ-Nanobody E
29.41Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
29.41Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
29.41Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
29.17Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
29.17Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
28.57Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
28.57Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
28.57Single6HLLCP999946HLL-NK1-CP99994
28.57Single7F8XNN90567F8X-CCKA-NN9056
28.57Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
28.57Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
28.57Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
28.57Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
28.57Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
28.57Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
28.57Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
28.57Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
28.57Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
28.57Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
28.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
27.78Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
27.78Single7EPENAM5637EPE-mGlu-NAM563
27.78Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
27.78Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
27.78Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
27.78Single7PX4PSB-21137PX4-A2A-PSB-2113
27.78Single7TUYGSK682753A7TUY-GPR183-GSK682753A
27.78Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
27.78Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
27.78Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
27.78Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
27.78Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
27.78Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
27.78Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
27.78Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
27.78Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
27.78Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
27.78Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
27.27Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
27.27Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
27.27Single5MZPCaffeine5MZP-A2A-Caffeine-Na
27.27Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
27.27Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
27.27Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
27.27Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
27.27Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
26.92Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
26.67Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
26.67Single4S0VSuvorexant4S0V-OX2-Suvorexant
26.67Single5K2DZM2413855K2D-A2A-ZM241385
26.67Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
26.67Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
26.67Single5WS3EMPA5WS3-OX2-EMPA
26.67Single6JZHZM2413856JZH-A2A-ZM241385-Na
26.67Single6PS7ZM2413856PS7-A2A-ZM241385-Na
26.67Single6TPJSuvorexant6TPJ-OX2-Suvorexant
26.67Single7F8ULintitript7F8U-CCKA-Lintitript
26.67Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
26.67Single8GNGIstradefylline8GNG-A2A-Istradefylline
26.67Single8IHKAcifran8IHK-HCA3-Acifran
26.67Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
26.67Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
26.67Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
26.67Consensusmglu_onOther Ligandmglu2_on mglu4_on
26.67Consensusorexin_offOrthosteric Ligandox2_off ox1_off
26.32Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.32Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
26.32Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
26.32Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
26.32Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
26.32Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
26.32Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
26.32Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
26.32Single8WU1KCA8WU1-CB1-KCA-Arrestin1
26.32Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
26.32Consensusdp_offOrthosteric Liganddp2_off
26.32Consensusgi_class-fOther Ligandgi_frizzled
26.32Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
26.32Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
26.32Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
26.09Consensusangiotensin_onOrthosteric Ligandat1_on
26.09Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
26.09Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
26.09Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
26.09Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
25.93Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
25.00Single3REYPubChem 56973REY-A2A-PubChem 5697
25.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
25.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
25.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
25.00Single5IU4ZM2413855IU4-A2A-ZM241385-Na
25.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
25.00Single5K2CZM2413855K2C-A2A-ZM241385-Na
25.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
25.00Single5NLXZM2413855NLX-A2A-ZM241385-Na
25.00Single5NM4ZM2413855NM4-A2A-ZM241385-Na
25.00Single5UVIZM2413855UVI-A2A-ZM241385
25.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
25.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
25.00Single6MH8ZM2413856MH8-A2A-ZM241385
25.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
25.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
25.00Single6TPKRetosiban6TPK-OT-Retosiban
25.00Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
25.00Single7AROLUF58337ARO-A2A-LUF5833-Na
25.00Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
25.00Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
25.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
25.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
25.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
25.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
25.00Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
25.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
25.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
25.00Single8PWNTheophylline8PWN-A2A-Theophylline
25.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
25.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
25.00Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
25.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
25.00Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusorexin_onOrthosteric Ligandox2_on
25.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
25.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
25.00Consensuss1p_offOrthosteric Ligands1p1_off
25.00Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusvasopressin-ot_offOrthosteric Ligandot_off
24.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single5EE7MK08935EE7-Glucagon-MK0893
23.81Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
23.81Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
23.81Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
23.81Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
23.81Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
23.81Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
23.81Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
23.81Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
23.81Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
23.81Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
23.81Consensuslpl_offOrthosteric Ligands1p_off lpa_off
23.81Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
23.53Single5UENDU1725UEN-A1-DU172
23.53Single6D27CAY104716D27-DP2-CAY10471
23.53Single6FFHFenobam6FFH-mGlu5-Fenobam
23.53Single6GPSMK08126GPS-CCR2-MK0812
23.53Single6IIVDaltroban6IIV-TP-Daltroban
23.53Single6LPJZM2413856LPJ-A2A-ZM241385-Na
23.53Single6LPKZM2413856LPK-A2A-ZM241385-Na
23.53Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
23.53Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
23.53Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
23.53Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
23.53Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
23.53Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
23.53Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
23.08Single3RFMCaffeine3RFM-A2A-Caffeine
23.08Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
23.08Single8A2OTheophylline8A2O-A2A-Theophylline-Na
23.08Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
23.08Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
22.73Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
22.73Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
22.73Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
22.73Consensussst_onOrthosteric Ligandsst2_on sst4_on
22.22Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
22.22Single6GPXMK08126GPX-CCR2-MK0812
22.22Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
22.22Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
22.22Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
22.22Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
22.22Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
22.22Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
22.22Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
22.22Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
22.22Consensusendothelin_onOrthosteric Ligandetb_on eta_on
22.22Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
22.22Consensusgo_class-b1Orthosteric Ligandgo_crf
22.22Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
21.74Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
21.74Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
21.74Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
21.74Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
21.74Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
21.74Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
21.74Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
21.74Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
21.74Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
21.74Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
21.43Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
21.43Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
21.43Single6IGLIRL16206IGL-ETB-IRL1620
21.43Single6ME5Agomelatine6ME5-MT1-Agomelatine
21.43Single6ME9Ramelteon6ME9-MT2-Ramelteon
21.43Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
21.43Single7WC5Psilocin7WC5-5-HT2A-Psilocin
21.43Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
21.43Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
21.43Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
21.43Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
21.05Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
21.05Single5XR8AM8415XR8-CB1-AM841
21.05Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
21.05Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
21.05Single7P2L4YI7P2L-mGlu5-4YI
21.05Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
21.05Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
21.05Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
21.05Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
21.05Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
21.05Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
21.05Consensuscck_onOrthosteric Ligandccka_on cckb_on
21.05Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
21.05Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
21.05Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Consensuslpa_offOrthosteric Ligandlpa1_off
21.05Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
21.05Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
20.83Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
20.83Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
20.83Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
20.83Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
20.83Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
20.83Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
20.83Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
20.69Single5GLHEndothelin-15GLH-ETB-Endothelin-1
20.69Single6IGKEndothelin-36IGK-ETB-Endothelin-3
20.69Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.69Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
20.00Single3OE9IT1t3OE9-CXCR4-IT1t
20.00Single4N4WSANT-14N4W-SMO-SANT-1
20.00Single5X33BIIL2605X33-BLT1-BIIL260
20.00Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
20.00Single6IIURamatroban6IIU-TP-Ramatroban
20.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
20.00Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
20.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
20.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
20.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
20.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
20.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
20.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
20.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
20.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
20.00Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
20.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
20.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
20.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
20.00Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
20.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
20.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
20.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
20.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
20.00Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
20.00Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
20.00Consensusclass-b2_onOrthosteric Ligandadgrg_on
20.00Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
20.00Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
20.00Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
20.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
20.00Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
20.00Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
20.00Consensusgo_class-b2Orthosteric Ligandgo_adhesion
20.00Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
19.35Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
19.23Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
19.23Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
19.23Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
19.23Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
19.23Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
19.23Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
19.23Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
19.23Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
19.23Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
19.23Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
19.23Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
19.23Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
19.23Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single6K1QIRL25006K1Q-ETB-IRL2500
19.05Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
19.05Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
19.05Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
19.05Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
19.05Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
19.05Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
19.05Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
19.05Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
19.05Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
19.05Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
19.05Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.75Single3PWHZM2413853PWH-A2A-ZM241385
18.75Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
18.75Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
18.75Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
18.75Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
18.75Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
18.75Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
18.75Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
18.75Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
18.75Single7XRRLemborexant7XRR-OX2-Lemborexant
18.75Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
18.75Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
18.75Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
18.75Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
18.52Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
18.52Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
18.52Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
18.52Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
18.52Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
18.52Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
18.52Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
18.52Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
18.18Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
18.18Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
18.18Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
18.18Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
18.18Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
18.18Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensuslpl_onOrthosteric Ligands1p_on lpa_on
18.18Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
17.86Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
17.86Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
17.86Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
17.86Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
17.86Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
17.86Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
17.65Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
17.65Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
17.65Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
17.65Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
17.65Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
17.65Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
17.65Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
17.65Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
17.39Single4XT1Fractalkine4XT1-US28-Fractalkine
17.39Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Single7QA8Peptide7QA8-STE2-Peptide
17.39Single7QA8Peptide7QA8-STE2-Peptide
17.39Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
17.39Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
17.39Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
17.39Consensusclass-d_offOrthosteric Ligandste2_off
17.39Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
17.39Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
17.39Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
17.39Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
17.39Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
17.24Single6LMLGlucagon6LML-Glucagon-Glucagon
17.24Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
17.24Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
17.24Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
17.24Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
17.24Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
17.24Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
17.24Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
17.24Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.67Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
16.67Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
16.67Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
16.67Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
16.67Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
16.67Single7F83PF-051904577F83-Ghrelin-PF-05190457
16.67Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
16.67Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
16.67Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
16.67Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
16.67Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
16.67Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
16.67Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
16.67Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
16.67Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
16.67Consensuscck_offOrthosteric Ligandccka_off
16.67Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
16.67Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
16.67Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67Consensushcar_offOrthosteric Ligandsuccinate_off
16.67Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
16.67Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
16.67Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
16.67Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
16.13Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
16.13Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
16.13Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
16.13Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
16.13Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
16.13Consensusglp_onOrthosteric Ligandglp1_on glp2_on
16.00Single3OE0CVX153OE0-CXCR4-CVX15
16.00Single6W25SHU91196W25-MC4-SHU9119-Ca
16.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
16.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
16.00Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
15.79Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
15.79Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
15.79Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
15.79Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
15.79Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
15.79Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
15.79Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
15.79Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.79Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
15.79Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single7YXAONO-54306087YXA-S1P5-ONO-5430608
15.79Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
15.79Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
15.79Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
15.79Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
15.79Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
15.79Consensusep_offOrthosteric Ligandep4_off
15.79Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
15.79Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
15.62Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
15.62Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
15.38Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
15.38Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
15.38Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.38Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
15.38Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
15.38Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
15.38Consensusclass-d_onOrthosteric Ligandste2_on
15.38Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
15.38Consensusgi_class-dOrthosteric Ligandgi_ste
15.38Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.38Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
15.15Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
15.15Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
15.15Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
15.15Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.00Single5XRAAM115425XRA-CB1-AM11542
15.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
15.00Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
15.00Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
15.00Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
15.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
15.00Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
15.00Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
15.00Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
15.00Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
15.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
15.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
15.00Consensuschemerin_onOrthosteric Ligandcml1_on
15.00Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
15.00Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
15.00Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
15.00Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.00Consensuslpa_onOrthosteric Ligandlpa1_on
15.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
15.00Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
14.81Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
14.81Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
14.81Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
14.81Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
14.81Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
14.81Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
14.81Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
14.81Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
14.71Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
14.71Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
14.71Consensuspth_onOrthosteric Ligandpth1_on pth2_on
14.29Single4XT3Fractalkine4XT3-US28-Fractalkine
14.29Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
14.29Single6FJ3PTH6FJ3-PTH1-PTH
14.29Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
14.29Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
14.29Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
14.29Single6TQ9SB-4081246TQ9-OX1-SB-408124
14.29Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
14.29Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
14.29Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
14.29Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
14.29Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
14.29Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
14.29Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
14.29Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
14.29Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
14.29Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
14.29Consensusclass-d_onOrthosteric Ligandste2_on
14.29Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
14.29Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
13.89Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
13.89Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.79Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
13.79Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.79Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
13.79Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
13.79Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
13.79Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
13.79Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
13.79Consensusgi_class-dOrthosteric Ligandgi_ste
13.79Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
13.79Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.79Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.64Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
13.64Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
13.64Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
13.64Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
13.64Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
13.64Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
13.51Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
13.33Single3OE6IT1t3OE6-CXCR4-IT1t
13.33Single3OE8IT1t3OE8-CXCR4-IT1t
13.33Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.33Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
13.33Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.33Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
13.33Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
13.33Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single8IY6Endothelin-18IY6-ETB-Endothelin-1
13.33Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
13.33Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
13.33Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
13.33Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.33Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
13.04Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
13.04Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
13.04Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
13.04Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
13.04Consensusclass-d_offOrthosteric Ligandste2_off
13.04Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
13.04Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Consensusgs_class-b2Orthosteric Ligandgs_adgr
13.04Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
13.04Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
12.90Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
12.50Single5L7IVismodegib5L7I-SMO-Vismodegib
12.50Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
12.50Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
12.50Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
12.50Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
12.50Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
12.50Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
12.50Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
12.12Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
12.12Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
12.12Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
12.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
12.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
12.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
12.00Single7SK5CXCL127SK5-ACKR3-CXCL12
12.00Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
12.00Consensussst_offOrthosteric Ligandsst2_off
12.00Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
11.76Single3ODUIT1t3ODU-CXCR4-IT1t
11.76Single5U09Taranabant5U09-CB1-Taranabant
11.76Single5ZKQABT-4915ZKQ-PAF-ABT-491
11.76Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
11.76Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.76Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.76Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
11.76Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
11.76Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
11.76Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.76Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.76Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
11.76Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
11.54Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
11.54Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
11.54Single7XNACYN1548067XNA-SST2-CYN154806
11.54Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
11.54Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
11.54Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
11.43Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.11Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
11.11Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.11Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.11Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
11.11Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
11.11Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
11.11Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
11.11Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
11.11Single8K2WAMG4878K2W-CXCR3-AMG487
11.11Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
11.11Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
11.11Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
11.11Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
11.11Consensusgnrh_offOrthosteric Ligandgnrh1_off
11.11Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
11.11Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.81Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
10.71Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
10.71Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
10.71Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
10.71Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
10.53Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
10.53Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
10.53Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
10.53Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.53Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
10.53Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
10.34Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
10.34Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.34Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
10.34Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
10.34Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.26Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
10.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
10.00Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
10.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
10.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
10.00Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
10.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
10.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
10.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
10.00Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
10.00Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
10.00Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
10.00Consensusclass-c_offOther Ligandgabab_off mglu_off
10.00Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
9.68Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
9.68Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
9.68Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
9.52Single5TZR-5TZR-FFA1 (GPR40)-MK8666
9.52Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
9.52Single7F1TMIP-1a7F1T-CCR5-MIP-1a
9.52Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
9.52Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
9.52Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
9.38Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
9.38Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
9.09Single6OS2TRV0266OS2-AT1-TRV026
9.09Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
9.09Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
9.09Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
9.09Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
9.09Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
9.09Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
9.09Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
9.09Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
8.82Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
8.82Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
8.70Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
8.70Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
8.70Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
8.70Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
8.70Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.57Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
8.33Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
8.33Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
8.33Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
8.33Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
8.33Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
8.33Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
8.00Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
8.00Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
8.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
8.00Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
8.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
7.69Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
7.69Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
7.69Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
7.69Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
7.69Single7SHEPI; PE7SHE-GPR158-PI; PE
7.69Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
7.41Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
7.41Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
7.41Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
7.14Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
7.14Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.14Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
7.14Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
7.14Consensusclass-c_onOther Ligandgabab_on mglu_on
7.14Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
6.90Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Single7SK3CXCL127SK3-ACKR3-CXCL12
6.67Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
6.67Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.67Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
6.67Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
6.67Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
6.45Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.45Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
6.25Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
6.25Single6LI0GTPL98046LI0-GPR52-GTPL9804
6.25Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
6.25Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
6.25Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
6.25Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
5.88Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
5.88Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
5.88Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
5.88Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
5.88Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
5.88Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.88Consensusclass-t_onOrthosteric Ligandtaste2_on
5.88Consensusgs_class-tOrthosteric Ligandgs_taste
5.88Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.88Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.88Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.88Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.56Single4K5YCP-3763954K5Y-CRF1-CP-376395
5.56Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
5.56Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.56Single7F8YDevazepide7F8Y-CCKA-Devazepide
5.56Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
5.56Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
5.56Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
5.56Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
5.56Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
5.56Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.56Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.56Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
5.56Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.26Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
5.26Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
5.26Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
5.26Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
5.26Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
5.26Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
5.26Single8IYXYL-3658IYX-GPR34-YL-365
5.26Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.26Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
5.26Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.26Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
5.26Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
5.00Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
5.00Single4Z9GCP-3763954Z9G-CRF1-CP-376395
5.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
5.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
5.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
5.00Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.00Single8GTIBMK-C2058GTI-CRF1-BMK-C205
5.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.00Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
4.76Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
4.76Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
4.76Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
4.76Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
4.76Single8GTGBMK-I1528GTG-CRF1-BMK-I152
4.76Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
4.76Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.76Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.55Single5V56TC1145V56-SMO-TC114
4.55Single5V57TC1145V57-SMO-TC114
4.55Single6OS1TRV0266OS1-AT1-TRV026
4.55Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
4.55Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
4.55Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.55Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
4.55Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.35Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
4.35Single4PY02MeSATP4PY0-P2Y12-2MeSATP
4.35Single4XEENeurotensin4XEE-NTS1-Neurotensin
4.35Single4XESNeurotensin4XES-NTS1-Neurotensin
4.35Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
4.35Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.35Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
4.35Single7SHEPI; PE7SHE-GPR158-PI; PE
4.35Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
4.35Single8GTMBMK-C2038GTM-CRF1-BMK-C203
4.35Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
4.35Consensuschemokine_offOrthosteric Ligandcxcr_off
4.35Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
4.35Consensuscxcr_offOrthosteric Ligandcxcr4_off
4.35Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
4.35Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
4.35Consensusnts_offOrthosteric Ligandnts1_off
4.17Single4BUONeurotensin4BUO-NTS1-Neurotensin
4.17Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
4.17Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
4.17Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
4.17Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
4.17Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
4.17Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.17Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
4.17Consensuscyslt_offOrthosteric Ligandcyslt2_off
4.17Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00Single6KNMJN241-96KNM-Apelin-JN241-9
4.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
4.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
4.00Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
3.85Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
3.85Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
3.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.57Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.56Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2

PDB Summary
PDB 8JLN
Class A
SubFamily Amine
Type Trace amine receptors
SubType TA1
Species Homo Sapiens
Ligand T1AM
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.24
Date 2023-11-15
D.O.I. 10.1038/s41586-023-06804-z
Net Summary
Imin 2.69
Number of Linked Nodes 864
Number of Links 992
Number of Hubs 133
Number of Links mediated by Hubs 511
Number of Communities 31
Number of Nodes involved in Communities 210
Number of Links involved in Communities 279
Path Summary
Number Of Nodes in MetaPath 126
Number Of Links MetaPath 125
Number of Shortest Paths 872190
Length Of Smallest Path 3
Average Path Length 35.3556
Length of Longest Path 76
Minimum Path Strength 1.335
Average Path Strength 6.49068
Maximum Path Strength 24.66
Minimum Path Correlation 0.7
Average Path Correlation 0.979454
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.27273
Average % Of Corr. Nodes 43.0483
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.8742
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeUJF
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeUJF
Name4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol
Synonyms
Identifier4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol
FormulaC14 H14 I N O2
Molecular Weight355.171
SMILESc1cc(ccc1O)Oc2ccc(cc2I)CCN
PubChem9950514
Formal Charge0
Total Atoms32
Total Chiral Atoms0
Total Bonds33
Total Aromatic Bonds12

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8JLN_Chain_A
RNEEKAQRE ANKKIEKQL QKDKQVYRA THRLLLLGA GESGKNTIV 
KQMRISGIF ETKFQVDKV NFHMFDVGA QRDERRKWI QCFNDVTAI 
IFVVASSSY NMVIREDNQ TNRLQAALK LFDSIWNNK WLRDTSVIL 
FLNKQDLLA EKVLAGKSK IEDYFPEFA RYTTPEDAT PEPGEDPRV 
TRAKYFIRD EFLRISTAS GDGRHYCYP HFTCSVDTE NIRRVFNDC 
RDIIQRMHL RQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8JLN_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ96RJ0
Sequence
>8JLN_Chain_R
NDVRASLYS LMVLIILTT LVGNLIVIV SISHFKQLH TPTNWLIHS 
MATVDFLLG CLVMPYSMV RSAEHCWYF GEVFCKIHT STDIMLSSA 
SIFHLSFIS IDRYYAVCD PLRYKAKMN ILVICVMIF ISWSVPAVF 
AFGMIFLEL NFKGAEEIY YKHVHCRGG CSVFFSKIS GVLTFMTSF 
YIPGSIMLC VYYRIYLIA KEQARLISD ANQKLQERK AVKTLGIVM 
GVFLICWCP FFICTVMDP FLHYIIPPT LNDVLIWFG YLNSTFNPM 
VYAFFYPWF RKALKMM


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8JLN_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
ta1_on8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
8W88-TA1-SEP-363856-Gs/&β;1/&γ;2
8JLN-TA1-T1AM-Gs/&β;1/&γ;2
8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
gs_tar8W88-TA1-SEP-363856-Gs/&β;1/&γ;2
8JLN-TA1-T1AM-Gs/&β;1/&γ;2
8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JLJAAmineTrace amine receptorsTA1Mus musclusT1AM-chim(NtGi1-Gs)/&β;1/&γ;23.12023-11-1510.1038/s41586-023-06804-z
8JLKAAmineTrace amine receptorsTA1Mus musclusUlotaront-chim(NtGi1-Gs)/&β;1/&γ;23.222023-11-1510.1038/s41586-023-06804-z
8JLNAAmineTrace amine receptorsTA1Homo sapiensT1AM-Gs/&β;1/&γ;23.242023-11-1510.1038/s41586-023-06804-z
8JLOAAmineTrace amine receptorsTA1Homo sapiensUlotaront-Gs/&β;1/&γ;23.522023-11-1510.1038/s41586-023-06804-z
8JLPAAmineTrace amine receptorsTA1Homo sapiensRalmitaront-Gs/&β;1/&γ;23.232023-11-1510.1038/s41586-023-06804-z
8JLQAAmineTrace amine receptorsTA1Homo sapiensFenoldopam-Gs/&β;1/&γ;22.842023-11-1510.1038/s41586-023-06804-z
8JLRAAmineTrace amine receptorsTA1Homo sapiensA77636-chim(NtGi1-Gs)/&β;1/&γ;232023-11-1510.1038/s41586-023-06804-z
8JSOAAmineTrace amine receptorsTA1Homo sapiensAMPH-chim(NtGi1-Gs)/&β;1/&γ;23.42023-11-1510.1038/s41586-023-06804-z
8UHBAAmineTrace amine receptorsTA1Homo sapiensRO5256390-Gs/&β;1/&γ;23.352024-01-1010.1038/s41467-023-44601-4
8W87AAmineTrace amine receptorsTA1Homo sapiensMETH-chim(NtGi1L-Gs)/&β;1/&γ;22.82023-11-2210.1038/s41586-023-06775-1
8W88AAmineTrace amine receptorsTA1Homo sapiensSEP-363856-Gs/&β;1/&γ;22.62023-11-2210.1038/s41586-023-06775-1
8W89AAmineTrace amine receptorsTA1Homo sapiensPEA-chim(NtGi1L-Gs)/&β;1/&γ;232023-11-2210.1038/s41586-023-06775-1
8W8AAAmineTrace amine receptorsTA1Homo sapiensRO5256390-chim(NtGi1L-Gs)/&β;1/&γ;22.82023-11-2210.1038/s41586-023-06775-1
8WC3AAmineTrace amine receptorsTA1Mus musculusSEP-363856-chim(NtGi1-Gs)/&β;1/&γ;232023-12-2710.1016/j.cell.2023.10.014
8WC4AAmineTrace amine receptorsTA1Mus musculusZH8651-chim(NtGi1-Gs)/&β;1/&γ;23.12023-12-2710.1016/j.cell.2023.10.014
8WC5AAmineTrace amine receptorsTA1Mus musculusTetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;23.32023-12-2710.1016/j.cell.2023.10.014
8WC6AAmineTrace amine receptorsTA1Mus musculus2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;23.22023-12-2710.1016/j.cell.2023.10.014
8WC7AAmineTrace amine receptorsTA1Mus musculusZH8667-chim(NtGi1-Gs)/&β;1/&γ;23.12023-12-2710.1016/j.cell.2023.10.014
8WC8AAmineTrace amine receptorsTA1Mus musculusZH8651-chim(NtGi1-Gs)/&β;1/&γ;22.92023-12-2710.1016/j.cell.2023.10.014
8WC9AAmineTrace amine receptorsTA1Mus musculusZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;23.22023-12-2710.1016/j.cell.2023.10.014
8WCAAAmineTrace amine receptorsTA1Homo sapiens2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;23.482023-12-2710.1016/j.cell.2023.10.014
8WCBAAmineTrace amine receptorsTA1Mus musculusCyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;23.12023-12-2710.1016/j.cell.2023.10.014
8WCCAAmineTrace amine receptorsTA1Mus musculusCyclohexylammonium ion--3.042023-12-2710.1016/j.cell.2023.10.014




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