psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E104	R:R:N107	6.57	No	No	0	1	4
2	R:R:K110	R:R:K113	8.62	No	No	0	3	1
3	R:R:S112	R:R:Y116	8.9	No	No	0	2	3
4	R:R:H117	R:R:K113	9.17	No	No	0	2	1
5	R:R:H115	R:R:R341	13.54	No	No	0	4	4
6	R:R:H115	R:R:Y346	4.36	No	Yes	0	4	6
7	R:R:V118	R:R:Y346	11.36	No	Yes	0	4	6
8	R:R:A349	R:R:I122	3.25	No	No	0	6	7
9	R:R:H127	R:R:N123	6.38	Yes	Yes	2	7	7
10	R:R:N123	R:R:W169	4.52	Yes	Yes	2	7	7
11	R:R:E352	R:R:N123	13.15	No	Yes	2	8	7
12	R:R:N123	R:R:S353	2.98	Yes	Yes	2	7	8
13	R:R:W169	R:R:Y124	5.79	Yes	No	2	7	6
14	R:R:F170	R:R:Y124	4.13	No	No	2	7	6
15	R:R:Q173	R:R:Y124	5.64	No	No	2	7	6
16	R:R:G126	R:R:S353	3.71	No	Yes	2	8	8
17	R:R:F354	R:R:G126	4.52	Yes	No	2	6	8
18	R:R:H127	R:R:N166	5.1	Yes	No	0	7	7
19	R:R:H127	R:R:W169	44.43	Yes	Yes	2	7	7
20	R:R:E352	R:R:H127	3.69	No	Yes	2	8	7
21	R:R:H127	R:R:S353	2.79	Yes	Yes	2	7	8
22	R:R:C128	R:R:F170	2.79	No	No	0	6	7
23	R:R:F354	R:R:I129	3.77	Yes	No	0	6	5
24	R:R:G356	R:R:S130	3.71	No	No	0	9	9
25	R:R:A133	R:R:S360	3.42	No	No	0	6	8
26	R:R:I159	R:R:L134	4.28	No	No	0	7	8
27	R:R:I163	R:R:L134	2.85	No	No	0	7	8
28	R:R:L134	R:R:S360	3	No	No	0	8	8
29	R:R:I163	R:R:L135	2.85	No	No	0	7	3
30	R:R:F138	R:R:L142	4.87	No	No	0	6	3
31	R:R:F138	R:R:I159	3.77	No	No	0	6	7
32	R:R:A160	R:R:F138	2.77	No	No	0	3	6
33	R:R:F141	R:R:N152	8.46	Yes	No	5	7	8
34	R:R:F141	R:R:H155	9.05	Yes	Yes	0	7	9
35	R:R:A363	R:R:F141	2.77	No	Yes	0	8	7
36	R:R:F141	R:R:N367	10.87	Yes	No	5	7	9
37	R:R:I147	R:R:L142	2.85	No	No	0	7	3
38	R:R:I147	R:R:R145	3.76	No	No	0	7	6
39	R:R:R145	R:R:R148	24.52	No	No	0	6	7
40	R:R:N152	R:R:S146	2.98	No	No	0	8	6
41	R:R:R148	R:R:R225	6.4	No	No	0	7	4
42	R:R:I154	R:R:L150	4.28	Yes	No	0	8	6
43	R:R:D224	R:R:L150	5.43	No	No	0	5	6
44	R:R:L150	R:R:R227	6.07	No	No	0	6	4
45	R:R:H155	R:R:R151	4.51	Yes	No	0	9	8
46	R:R:R151	R:R:Y212	8.23	No	No	0	8	7
47	R:R:N152	R:R:N367	5.45	No	No	5	8	9
48	R:R:I153	R:R:R225	5.01	No	No	0	6	4
49	R:R:A228	R:R:I153	3.25	No	No	0	5	6
50	R:R:I154	R:R:W205	3.52	Yes	Yes	0	8	9
51	R:R:E209	R:R:I154	5.47	No	Yes	0	9	8
52	R:R:I154	R:R:Y212	3.63	Yes	No	0	8	7
53	R:R:F231	R:R:I154	5.02	No	Yes	0	6	8
54	R:R:E209	R:R:H155	11.08	No	Yes	0	9	9
55	R:R:H155	R:R:L366	3.86	Yes	No	0	9	5
56	R:R:N157	R:R:W205	15.82	No	Yes	1	9	9
57	R:R:N157	R:R:W236	6.78	No	Yes	1	9	9
58	R:R:F162	R:R:L158	4.87	Yes	No	0	7	8
59	R:R:A363	R:R:I159	3.25	No	No	0	8	7
60	R:R:F162	R:R:N202	20.54	Yes	Yes	1	7	7
61	R:R:F162	R:R:V359	13.11	Yes	No	0	7	9
62	R:R:F162	W:W:?1	5.09	Yes	Yes	1	7	0
63	R:R:F198	R:R:L164	13.4	Yes	No	0	6	5
64	R:R:R165	R:R:Y195	10.29	Yes	Yes	0	8	5
65	R:R:H199	R:R:R165	12.41	Yes	Yes	0	5	8
66	R:R:N202	R:R:R165	10.85	Yes	Yes	0	7	8
67	R:R:Q355	R:R:R165	3.5	No	Yes	0	9	8
68	R:R:T168	R:R:Y195	4.99	No	Yes	0	4	5
69	R:R:F198	R:R:T168	3.89	Yes	No	0	6	4
70	R:R:F170	R:R:W169	9.02	No	Yes	2	7	7
71	R:R:Q173	R:R:W169	23	No	Yes	2	7	7
72	R:R:W169	R:R:Y195	2.89	Yes	Yes	0	7	5
73	R:R:V171	R:R:V191	4.81	No	No	0	4	5
74	R:R:V172	R:R:Y195	3.79	No	Yes	0	6	5
75	R:R:M176	R:R:T175	3.01	No	No	0	6	3
76	R:R:T175	R:R:V191	3.17	No	No	0	3	5
77	R:R:P178	R:R:S177	3.56	No	No	6	2	4
78	R:R:E179	R:R:S177	7.19	No	No	6	1	4
79	R:R:S177	R:R:V180	3.23	No	No	0	4	2
80	R:R:E179	R:R:P178	6.29	No	No	6	1	2
81	R:R:H181	R:R:K257	9.17	No	No	0	4	3
82	R:R:S183	R:R:V185	3.23	No	No	0	2	3
83	R:R:N184	R:R:R189	16.87	No	Yes	1	6	6
84	R:R:N184	R:R:N255	6.81	No	Yes	1	6	4
85	R:R:C258	R:R:N184	3.15	No	No	0	9	6
86	R:R:V185	R:R:W187	12.26	No	No	0	3	2
87	R:R:C188	R:R:V185	3.42	No	No	0	9	3
88	R:R:G186	R:R:R189	4.5	No	Yes	0	2	6
89	R:R:C188	R:R:C258	7.28	No	No	0	9	9
90	R:R:N255	R:R:R189	7.23	Yes	Yes	1	4	6
91	R:R:R189	R:R:W259	18.99	Yes	Yes	1	6	9
92	R:R:A260	R:R:T192	3.36	No	No	0	6	7
93	R:R:N196	R:R:W246	4.52	No	Yes	1	8	8
94	R:R:N196	R:R:Y272	12.79	No	Yes	1	8	7
95	R:R:F198	R:R:Y197	5.16	Yes	Yes	0	6	8
96	R:R:T201	R:R:Y197	8.74	Yes	Yes	1	7	8
97	R:R:W236	R:R:Y197	3.86	Yes	Yes	1	9	8
98	R:R:P239	R:R:Y197	2.78	Yes	Yes	1	9	8
99	R:R:I243	R:R:Y197	8.46	No	Yes	0	7	8
100	R:R:F203	R:R:H199	3.39	Yes	Yes	1	8	5
101	R:R:H199	R:R:M276	5.25	Yes	Yes	1	5	7
102	R:R:H199	R:R:Y327	3.27	Yes	Yes	1	5	8
103	R:R:P239	R:R:V200	5.3	Yes	No	0	9	7
104	R:R:M276	R:R:V200	3.04	Yes	No	0	7	7
105	R:R:N202	R:R:T201	2.92	Yes	Yes	1	7	7
106	R:R:T201	R:R:W236	6.06	Yes	Yes	1	7	9
107	R:R:P239	R:R:T201	3.5	Yes	Yes	1	9	7
108	R:R:N202	W:W:?1	4.1	Yes	Yes	1	7	0
109	R:R:F203	R:R:M276	14.93	Yes	Yes	1	8	7
110	R:R:F203	R:R:Y327	4.13	Yes	Yes	1	8	8
111	R:R:F203	W:W:?1	11.63	Yes	Yes	1	8	0
112	R:R:F204	R:R:V238	6.55	No	No	1	5	3
113	R:R:F204	R:R:P239	4.33	No	Yes	1	5	9
114	R:R:F204	R:R:V279	6.55	No	No	0	5	7
115	R:R:G235	R:R:W205	8.44	No	Yes	0	8	9
116	R:R:W205	R:R:W236	10.31	Yes	Yes	1	9	9
117	R:R:M206	W:W:?1	19.4	No	Yes	0	9	0
118	R:R:F207	R:R:V279	9.18	Yes	No	0	6	7
119	R:R:F207	R:R:I282	6.28	Yes	No	0	6	5
120	R:R:F207	R:R:N283	4.83	Yes	No	0	6	9
121	R:R:G210	R:R:N283	5.09	No	No	0	7	9
122	R:R:A216	R:R:Y212	5.34	No	No	0	7	7
123	R:R:I290	R:R:L213	5.71	No	No	0	8	8
124	R:R:A312	R:R:L213	3.15	No	No	0	7	8
125	R:R:F286	R:R:H214	10.18	No	No	0	7	7
126	R:R:L219	R:R:T215	4.42	No	No	0	4	6
127	R:R:I217	R:R:I290	4.42	Yes	No	0	7	8
128	R:R:I217	R:R:I293	4.42	Yes	Yes	3	7	6
129	R:R:L219	R:R:V218	2.98	No	No	0	4	6
130	R:R:I234	R:R:M230	2.92	No	No	0	5	3
131	R:R:P239	R:R:V238	3.53	Yes	No	1	9	3
132	R:R:F240	R:R:P241	4.33	No	No	0	4	4
133	R:R:F240	R:R:V244	3.93	No	No	0	4	3
134	R:R:I242	R:R:P275	5.08	No	No	0	6	8
135	R:R:K250	R:R:W246	13.92	Yes	Yes	1	6	8
136	R:R:W246	R:R:W259	5.62	Yes	Yes	1	8	9
137	R:R:D269	R:R:W246	5.58	Yes	Yes	1	6	8
138	R:R:W246	R:R:Y272	7.72	Yes	Yes	1	8	7
139	R:R:D254	R:R:K250	12.44	No	Yes	0	5	6
140	R:R:K250	R:R:W259	19.73	Yes	Yes	1	6	9
141	R:R:K250	R:R:T268	6.01	Yes	No	0	6	4
142	R:R:D269	R:R:K250	4.15	Yes	Yes	1	6	6
143	R:R:L251	R:R:N255	4.12	No	Yes	0	2	4
144	R:R:Y252	R:R:Y253	10.92	No	No	0	3	6
145	R:R:D254	R:R:E256	12.99	No	No	0	5	3
146	R:R:D254	R:R:V266	4.38	No	No	0	5	3
147	R:R:N255	R:R:W259	5.65	Yes	Yes	1	4	9
148	R:R:E256	R:R:R263	12.79	No	No	0	3	3
149	R:R:G261	R:R:K257	3.49	No	No	0	5	3
150	R:R:D269	R:R:K262	5.53	Yes	No	0	6	5
151	R:R:P264	R:R:R263	2.88	No	No	0	5	3
152	R:R:G265	R:R:Y267	5.79	No	No	0	6	1
153	R:R:Y267	R:R:Y270	10.92	No	No	0	1	7
154	R:R:D269	R:R:Y272	12.64	Yes	Yes	1	6	7
155	R:R:D269	R:R:Q273	6.53	Yes	No	1	6	7
156	R:R:Q273	R:R:Y272	13.53	No	Yes	1	7	7
157	R:R:M276	R:R:Y272	4.79	Yes	Yes	1	7	7
158	R:R:G274	R:R:P275	4.06	No	No	0	3	8
159	R:R:F284	R:R:L280	4.87	No	No	1	4	6
160	R:R:L280	W:W:?1	14.04	No	Yes	1	6	0
161	R:R:F286	R:R:I282	5.02	No	No	0	7	5
162	R:R:N283	W:W:?1	24.58	No	Yes	0	9	0
163	R:R:F284	W:W:?1	5.81	No	Yes	1	4	0
164	R:R:L287	R:R:V291	2.98	No	No	0	7	6
165	R:R:N289	R:R:R292	4.82	No	No	0	6	6
166	R:R:I290	R:R:L294	2.85	No	No	0	8	7
167	R:R:I293	R:R:K297	7.27	Yes	No	3	6	8
168	R:R:I293	R:R:L298	2.85	Yes	Yes	3	6	6
169	R:R:L294	R:R:L298	2.77	No	Yes	0	7	6
170	R:R:L294	R:R:R310	7.29	No	No	0	7	5
171	R:R:K297	R:R:T296	12.01	No	No	0	8	5
172	R:R:K297	R:R:L298	7.05	No	Yes	3	8	6
173	R:R:L298	R:R:S301	6.01	Yes	No	3	6	4
174	R:R:S301	R:R:T303	3.2	No	No	3	4	4
175	R:R:S301	R:R:T306	7.99	No	No	3	4	5
176	R:R:E305	R:R:T303	5.64	No	No	0	4	4
177	R:R:T303	R:R:T306	3.14	No	No	3	4	5
178	R:R:E305	R:R:S304	5.75	No	No	0	4	3
179	R:R:K311	R:R:K314	5.75	No	No	0	7	8
180	R:R:L317	R:R:V313	2.98	No	No	0	5	5
181	R:R:A315	R:R:F362	2.77	No	No	0	8	8
182	R:R:A315	R:R:F365	2.77	No	No	0	8	6
183	R:R:T316	W:W:?1	8.79	No	Yes	0	7	0
184	R:R:L319	R:R:L323	9.69	No	No	0	9	8
185	R:R:F362	R:R:L319	7.31	No	No	0	8	9
186	R:R:L320	W:W:?1	13.21	No	Yes	0	7	0
187	R:R:F358	R:R:L322	4.87	No	No	0	6	8
188	R:R:L323	R:R:Q355	3.99	No	No	1	8	9
189	R:R:L323	W:W:?1	4.13	No	Yes	1	8	0
190	R:R:G324	W:W:?1	3.06	No	Yes	0	9	0
191	R:R:I325	R:R:L329	4.28	No	Yes	0	6	6
192	R:R:I325	R:R:L351	2.85	No	No	0	6	5
193	R:R:T326	R:R:Y327	3.75	No	Yes	0	8	8
194	R:R:N348	R:R:T326	4.39	No	No	0	8	8
195	R:R:Y327	W:W:?1	4.2	Yes	Yes	1	8	0
196	R:R:L329	R:R:V332	5.96	Yes	No	4	6	5
197	R:R:F344	R:R:L329	4.87	No	Yes	4	6	6
198	R:R:L329	R:R:N348	4.12	Yes	No	0	6	8
199	R:R:P334	R:R:V332	7.07	Yes	No	4	5	5
200	R:R:F344	R:R:V332	7.87	No	No	4	6	5
201	R:R:F344	R:R:P334	23.12	No	Yes	4	6	5
202	R:R:D337	R:R:S340	5.89	No	No	0	3	2
203	R:R:E338	R:R:R341	11.63	No	No	0	3	4
204	R:R:V342	R:R:Y346	7.57	No	Yes	0	3	6
205	R:R:F347	R:R:L351	3.65	No	No	0	5	5
206	R:R:F350	R:R:F354	15	No	Yes	0	5	6
207	R:R:F354	R:R:S353	3.96	Yes	Yes	2	6	8
208	R:R:F354	R:R:F357	3.22	Yes	No	0	6	5
209	R:R:F354	R:R:F358	3.22	Yes	No	0	6	6
210	R:R:Q355	W:W:?1	4.76	No	Yes	1	9	0
211	R:R:F362	R:R:L366	3.65	No	No	0	8	5
212	R:R:E108	R:R:I105	2.73	No	No	0	2	3
213	R:R:H117	R:R:I121	2.65	No	No	0	2	4
214	R:R:F357	R:R:S130	2.64	No	No	0	5	9
215	R:R:H115	R:R:K111	2.62	No	No	0	4	4
216	R:R:F357	R:R:V361	2.62	No	No	0	5	5
217	R:R:A161	R:R:W236	2.59	No	Yes	0	8	9
218	R:R:A193	R:R:W246	2.59	No	Yes	1	5	8
219	R:R:A193	R:R:W259	2.59	No	Yes	1	5	9
220	R:R:A247	R:R:W259	2.59	No	Yes	0	5	9
221	R:R:L287	W:W:?1	2.48	No	Yes	0	7	0
222	R:R:V180	R:R:W187	2.45	No	No	0	2	2
223	R:R:I345	R:R:Y346	2.42	No	Yes	0	7	6
224	R:R:I271	R:R:W246	2.35	No	Yes	0	7	8
225	R:R:Q273	R:R:Y270	2.25	No	No	0	7	7
226	R:R:R341	R:R:Y116	2.06	No	No	0	4	3
227	R:R:F240	R:R:Y197	2.06	No	Yes	0	4	8
228	R:R:G237	R:R:P239	2.03	No	Yes	0	6	9
229	R:R:G335	R:R:P334	2.03	No	Yes	0	5	5
230	R:R:C211	R:R:G208	1.96	No	No	0	5	7
231	R:R:G249	R:R:T268	1.82	No	No	0	4	4
232	R:R:A137	R:R:C364	1.81	No	No	0	8	8
233	R:R:A119	R:R:A349	1.79	No	No	0	6	6
234	R:R:P334	R:R:S340	1.78	Yes	No	0	5	2
235	R:R:G235	R:R:I234	1.76	No	No	0	8	5
236	R:R:C149	R:R:S146	1.72	No	No	0	6	6
237	R:R:A137	R:R:S360	1.71	No	No	0	8	8
238	R:R:A144	R:R:S146	1.71	No	No	0	6	6
239	R:R:C188	R:R:T175	1.69	No	No	0	9	3
240	R:R:C258	R:R:T192	1.69	No	No	0	9	7
241	R:R:E256	R:R:G261	1.64	No	No	0	3	5
242	R:R:L320	R:R:P321	1.64	No	No	0	7	7
243	R:R:E336	R:R:G335	1.64	No	No	0	3	5
244	R:R:N333	R:R:P334	1.63	No	Yes	0	6	5
245	R:R:A119	R:R:I345	1.62	No	No	0	6	7
246	R:R:A156	R:R:I147	1.62	No	No	0	5	7
247	R:R:A309	R:R:I217	1.62	No	Yes	0	4	7
248	R:R:A245	R:R:I271	1.62	No	No	0	5	7
249	R:R:V132	R:R:V136	1.6	No	No	0	3	5
250	R:R:V291	R:R:V313	1.6	No	No	0	6	5
251	R:R:V342	R:R:V343	1.6	No	No	0	3	3
252	R:R:A312	R:R:L366	1.58	No	No	0	7	5
253	R:R:A349	R:R:N123	1.56	No	Yes	0	6	7
254	R:R:I217	R:R:V218	1.54	Yes	No	3	7	6
255	R:R:I293	R:R:V218	1.54	Yes	No	3	6	6
256	R:R:I242	R:R:V238	1.54	No	No	0	6	3
257	R:R:I248	R:R:V244	1.54	No	No	0	4	3
258	R:R:K110	R:R:V114	1.52	No	No	0	3	1
259	R:R:F207	R:R:G208	1.51	Yes	No	0	6	7
260	R:R:F231	R:R:G208	1.51	No	No	0	6	7
261	R:R:L140	R:R:V136	1.49	No	No	0	8	5
262	R:R:D337	R:R:V339	1.46	No	No	0	3	1
263	R:R:Q308	R:R:S368	1.44	No	No	0	5	4
264	R:R:I129	R:R:L125	1.43	No	No	0	5	6
265	R:R:I163	R:R:L131	1.43	No	No	0	7	6
266	R:R:I282	R:R:L278	1.43	No	No	0	5	3
267	R:R:I285	R:R:N289	1.42	No	No	0	3	6
268	R:R:K111	R:R:N107	1.4	No	No	0	4	4
269	R:R:A194	R:R:F198	1.39	No	Yes	0	4	6
270	R:R:A330	R:R:F331	1.39	No	No	0	7	5
271	R:R:E109	R:R:I105	1.37	No	No	0	2	3
272	R:R:I307	R:R:Q308	1.37	No	No	0	5	5
273	R:R:E104	R:R:M103	1.35	No	No	0	1	3
274	R:R:T268	R:R:Y253	1.25	No	No	0	4	6
275	R:R:F365	R:R:K311	1.24	No	No	0	6	7
276	R:R:I232	R:R:W205	1.17	No	Yes	1	4	9
277	R:R:I232	R:R:W229	1.17	No	No	0	4	2
278	R:R:I232	R:R:W236	1.17	No	Yes	1	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N123	5.718	5	2	7
2	R:R:H127	12.478	5	2	7
3	R:R:F141	7.7875	4	5	7
4	R:R:I154	4.384	5	0	8
5	R:R:H155	7.125	4	0	9
6	R:R:F162	10.9025	4	1	7
7	R:R:R165	9.2625	4	0	8
8	R:R:W169	14.9417	6	2	7
9	R:R:R189	11.8975	4	1	6
10	R:R:Y195	5.49	4	0	5
11	R:R:Y197	5.17667	6	1	8
12	R:R:F198	5.96	4	0	6
13	R:R:H199	6.08	4	1	5
14	R:R:T201	5.305	4	1	7
15	R:R:N202	9.6025	4	1	7
16	R:R:F203	8.52	4	1	8
17	R:R:W205	7.852	5	1	9
18	R:R:F207	5.45	4	0	6
19	R:R:I217	3	4	3	7
20	R:R:W236	5.12833	6	1	9
21	R:R:P239	3.57833	6	1	9
22	R:R:W246	6.04286	7	1	8
23	R:R:K250	11.25	5	1	6
24	R:R:N255	5.9525	4	1	4
25	R:R:W259	9.195	6	1	9
26	R:R:D269	6.886	5	1	6
27	R:R:Y272	10.294	5	1	7
28	R:R:M276	7.0025	4	1	7
29	R:R:I293	4.02	4	3	6
30	R:R:L298	4.67	4	3	6
31	R:R:Y327	3.8375	4	1	8
32	R:R:L329	4.8075	4	4	6
33	R:R:P334	7.126	5	4	5
34	R:R:Y346	6.4275	4	0	6
35	R:R:S353	3.36	4	2	8
36	R:R:F354	5.615	6	2	6
37	W:W:?1	8.94857	14	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H115	R:R:Y346	14.9187	4.36	No	Yes	0	4	6
2	R:R:A119	R:R:A349	24.398	1.79	No	No	0	6	6
3	R:R:A119	R:R:I345	22.8471	1.62	No	No	0	6	7
4	R:R:I345	R:R:Y346	21.2852	2.42	No	Yes	0	7	6
5	R:R:A349	R:R:N123	27.4675	1.56	No	Yes	0	6	7
6	R:R:N123	R:R:W169	47.3373	4.52	Yes	Yes	2	7	7
7	R:R:N123	R:R:S353	19.5824	2.98	Yes	Yes	2	7	8
8	R:R:F354	R:R:S353	31.8275	3.96	Yes	Yes	2	6	8
9	R:R:F354	R:R:F357	12.8796	3.22	Yes	No	0	6	5
10	R:R:I159	R:R:L134	12.2289	4.28	No	No	0	7	8
11	R:R:A363	R:R:I159	27.9121	3.25	No	No	0	8	7
12	R:R:A363	R:R:F141	29.2516	2.77	No	Yes	0	8	7
13	R:R:F141	R:R:H155	37.1963	9.05	Yes	Yes	0	7	9
14	R:R:H155	R:R:L366	37.9393	3.86	Yes	No	0	9	5
15	R:R:F362	R:R:L366	52.6247	3.65	No	No	0	8	5
16	R:R:F362	R:R:L319	56.5022	7.31	No	No	0	8	9
17	R:R:L319	R:R:L323	57.3265	9.69	No	No	0	9	8
18	R:R:L323	R:R:Q355	17.5759	3.99	No	No	1	8	9
19	R:R:Q355	R:R:R165	24.9892	3.5	No	Yes	0	9	8
20	R:R:R165	R:R:Y195	70.103	10.29	Yes	Yes	0	8	5
21	R:R:W169	R:R:Y195	76.4317	2.89	Yes	Yes	0	7	5
22	R:R:F138	R:R:I159	15.179	3.77	No	No	0	6	7
23	R:R:F138	R:R:L142	12.2289	4.87	No	No	0	6	3
24	R:R:I147	R:R:L142	10.7375	2.85	No	No	0	7	3
25	R:R:N202	R:R:R165	16.654	10.85	Yes	Yes	0	7	8
26	R:R:N202	R:R:T201	17.6952	2.92	Yes	Yes	1	7	7
27	R:R:T201	R:R:W236	19.6963	6.06	Yes	Yes	1	7	9
28	R:R:W205	R:R:W236	29.8915	10.31	Yes	Yes	1	9	9
29	R:R:I154	R:R:W205	25.2657	3.52	Yes	Yes	0	8	9
30	R:R:T168	R:R:Y195	11.8004	4.99	No	Yes	0	4	5
31	R:R:F198	R:R:T168	10.9382	3.89	Yes	No	0	6	4
32	R:R:F198	R:R:Y197	13.0694	5.16	Yes	Yes	0	6	8
33	R:R:W236	R:R:Y197	18.6714	3.86	Yes	Yes	1	9	8
34	R:R:E209	R:R:I154	15.9761	5.47	No	Yes	0	9	8
35	R:R:N202	W:W:?1	16.3937	4.1	Yes	Yes	1	7	0
36	R:R:N283	W:W:?1	17.0011	24.58	No	Yes	0	9	0
37	R:R:F207	R:R:N283	14.257	4.83	Yes	No	0	6	9
38	R:R:H199	R:R:R165	32.4024	12.41	Yes	Yes	0	5	8
39	R:R:H199	R:R:M276	35.1735	5.25	Yes	Yes	1	5	7
40	R:R:M276	R:R:Y272	100	4.79	Yes	Yes	1	7	7
41	R:R:W246	R:R:Y272	73.5358	7.72	Yes	Yes	1	8	7
42	R:R:W246	R:R:W259	53.0694	5.62	Yes	Yes	1	8	9
43	R:R:R189	R:R:W259	27.3265	18.99	Yes	Yes	1	6	9
44	R:R:N184	R:R:R189	24.4631	16.87	No	Yes	1	6	6
45	R:R:C258	R:R:N184	45.9544	3.15	No	No	0	9	6
46	R:R:C188	R:R:C258	36.9577	7.28	No	No	0	9	9
47	R:R:C188	R:R:T175	12.4892	1.69	No	No	0	9	3
48	R:R:N255	R:R:W259	27.3265	5.65	Yes	Yes	1	4	9
49	R:R:N184	R:R:N255	24.4631	6.81	No	Yes	1	6	4
50	R:R:C188	R:R:V185	21.7462	3.42	No	No	0	9	3
51	R:R:V185	R:R:W187	15.5857	12.26	No	No	0	3	2
52	R:R:V180	R:R:W187	12.4892	2.45	No	No	0	2	2
53	R:R:K250	R:R:W246	17.5488	13.92	Yes	Yes	1	6	8
54	R:R:D254	R:R:K250	23.5521	12.44	No	Yes	0	5	6
55	R:R:D254	R:R:E256	17.7278	12.99	No	No	0	5	3
56	R:R:D269	R:R:Y272	19.8536	12.64	Yes	Yes	1	6	7
57	R:R:D269	R:R:K250	18.8557	4.15	Yes	Yes	1	6	6
58	R:R:P239	R:R:T201	15.4772	3.5	Yes	Yes	1	9	7
59	R:R:P239	R:R:Y197	16.9469	2.78	Yes	Yes	1	9	8
60	R:R:H199	R:R:Y327	18.346	3.27	Yes	Yes	1	5	8
61	R:R:M276	R:R:V200	24.7994	3.04	Yes	No	0	7	7
62	R:R:A312	R:R:L366	31.8275	1.58	No	No	0	7	5
63	R:R:A312	R:R:L213	30.4067	3.15	No	No	0	7	8
64	R:R:I290	R:R:L213	29.0401	5.71	No	No	0	8	8
65	R:R:I217	R:R:I290	12.3048	4.42	Yes	No	0	7	8
66	R:R:K250	R:R:T268	11.8601	6.01	Yes	No	0	6	4
67	R:R:I290	R:R:L294	15.3796	2.85	No	No	0	8	7
68	R:R:L294	R:R:L298	12.4024	2.77	No	Yes	0	7	6
69	R:R:T326	R:R:Y327	42.7061	3.75	No	Yes	0	8	8
70	R:R:N348	R:R:T326	40.8785	4.39	No	No	0	8	8
71	R:R:L329	R:R:N348	39.0347	4.12	Yes	No	0	6	8
72	R:R:L329	R:R:V332	15.7863	5.96	Yes	No	4	6	5
73	R:R:F344	R:R:L329	15.7809	4.87	No	Yes	4	6	6
74	R:R:P334	R:R:V332	13.8503	7.07	Yes	No	4	5	5
75	R:R:F344	R:R:P334	13.8503	23.12	No	Yes	4	6	5
76	R:R:P334	R:R:S340	11.936	1.78	Yes	No	0	5	2
77	R:R:H127	R:R:W169	22.9067	44.43	Yes	Yes	2	7	7
78	R:R:H127	R:R:S353	18.5412	2.79	Yes	Yes	2	7	8
79	R:R:E209	R:R:H155	14.3438	11.08	No	Yes	0	9	9
80	R:R:L323	W:W:?1	40.6291	4.13	No	Yes	1	8	0
81	R:R:F203	W:W:?1	36.3557	11.63	Yes	Yes	1	8	0
82	R:R:Y327	W:W:?1	16.2039	4.2	Yes	Yes	1	8	0
83	R:R:F203	R:R:M276	46.3612	14.93	Yes	Yes	1	8	7
84	R:R:P239	R:R:V200	24.2245	5.3	Yes	No	0	9	7
85	R:R:F203	R:R:Y327	10.7104	4.13	Yes	Yes	1	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F162	R:R:L158	4.87	1	Yes	No	7	8	1	2
R:R:F162	R:R:N202	20.54	1	Yes	Yes	7	7	1	1
R:R:F162	R:R:V359	13.11	1	Yes	No	7	9	1	2
R:R:F162	W:W:?1	5.09	1	Yes	Yes	7	0	1	0
R:R:H199	R:R:R165	12.41	1	Yes	Yes	5	8	2	2
R:R:N202	R:R:R165	10.85	1	Yes	Yes	7	8	1	2
R:R:Q355	R:R:R165	3.5	1	No	Yes	9	8	1	2
R:R:F203	R:R:H199	3.39	1	Yes	Yes	8	5	1	2
R:R:H199	R:R:M276	5.25	1	Yes	Yes	5	7	2	2
R:R:H199	R:R:Y327	3.27	1	Yes	Yes	5	8	2	1
R:R:N202	R:R:T201	2.92	1	Yes	Yes	7	7	1	2
R:R:N202	W:W:?1	4.1	1	Yes	Yes	7	0	1	0
R:R:F203	R:R:M276	14.93	1	Yes	Yes	8	7	1	2
R:R:F203	R:R:Y327	4.13	1	Yes	Yes	8	8	1	1
R:R:F203	W:W:?1	11.63	1	Yes	Yes	8	0	1	0
R:R:M206	W:W:?1	19.4	0	No	Yes	9	0	1	0
R:R:F207	R:R:N283	4.83	0	Yes	No	6	9	2	1
R:R:G210	R:R:N283	5.09	0	No	No	7	9	2	1
R:R:F284	R:R:L280	4.87	1	No	No	4	6	1	1
R:R:L280	W:W:?1	14.04	1	No	Yes	6	0	1	0
R:R:N283	W:W:?1	24.58	0	No	Yes	9	0	1	0
R:R:F284	W:W:?1	5.81	1	No	Yes	4	0	1	0
R:R:L287	R:R:V291	2.98	0	No	No	7	6	1	2
R:R:T316	W:W:?1	8.79	0	No	Yes	7	0	1	0
R:R:L319	R:R:L323	9.69	0	No	No	9	8	2	1
R:R:L320	W:W:?1	13.21	0	No	Yes	7	0	1	0
R:R:L323	R:R:Q355	3.99	1	No	No	8	9	1	1
R:R:L323	W:W:?1	4.13	1	No	Yes	8	0	1	0
R:R:G324	W:W:?1	3.06	0	No	Yes	9	0	1	0
R:R:T326	R:R:Y327	3.75	0	No	Yes	8	8	2	1
R:R:Y327	W:W:?1	4.2	1	Yes	Yes	8	0	1	0
R:R:Q355	W:W:?1	4.76	1	No	Yes	9	0	1	0
R:R:L287	W:W:?1	2.48	0	No	Yes	7	0	1	0
R:R:L320	R:R:P321	1.64	0	No	No	7	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
78.57	Single	8GTI	BMK-C205	8GTI-CRF₁-BMK-C205
73.33	Single	8GTG	BMK-I152	8GTG-CRF₁-BMK-I152
66.67	Single	4Z9G	CP-376395	4Z9G-CRF₁-CP-376395
64.29	Single	4K5Y	CP-376395	4K5Y-CRF₁-CP-376395
36.84	Consensus	ffa3_on_allo	Other Ligand	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
35.00	Single	8J20	AR420626	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
28.57	Single	8TAO	CDPPB	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
27.78	Single	8HNN	SCH546738	8HNN-CXCR3-SCH546738
25.00	Single	6FFH	Fenobam	6FFH-mGlu₅-Fenobam
20.83	Single	5CGD	HTL14242	5CGD-mGlu₅-HTL14242
20.00	Single	6FFI	MMPEP	6FFI-mGlu₅-MMPEP
20.00	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
19.05	Single	7RBT	PubChem 163183774	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
18.18	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
17.39	Single	4OO9	Mavoglurant	4OO9-mGlu₅-Mavoglurant
17.39	Single	7P2L	4YI	7P2L-mGlu₅-4YI
17.39	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
16.67	Single	5X33	BIIL260	5X33-BLT₁-BIIL260
16.67	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
15.79	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
15.15	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
15.00	Single	6KK1	PubChem 68178630	6KK1-GLP-1-PubChem 68178630
14.71	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
14.71	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
14.71	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
14.71	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
14.29	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
13.95	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
13.89	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
13.89	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
13.64	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
13.64	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
13.64	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
13.04	Single	5CGC	HTL14242	5CGC-mGlu₅-HTL14242
13.04	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
12.50	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
12.50	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
12.50	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
12.00	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
12.00	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
12.00	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
12.00	Consensus	gi_class-f	Other Ligand	gi_frizzled
12.00	Consensus	gi_frizzled	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.90	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
11.54	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
11.54	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
11.54	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/&β;1/&γ;2
11.54	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
11.54	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
11.11	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
11.11	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
10.53	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
10.53	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
10.34	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
10.00	Single	7CA3	rac-BHFF	7CA3-GABA_B1, GABA_B2-rac-BHFF
10.00	Single	7V68	Iperoxo	7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
10.00	Single	8X2K	5YM	8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
9.68	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
9.52	Single	7C7Q	PubChem 7023848	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
9.52	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
9.52	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
9.52	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.52	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.52	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
9.52	Single	8A6C	All-trans-retinal	8A6C-Rhodopsin-All-trans-retinal
9.52	Single	8A6D	All-trans-retinal	8A6D-Rhodopsin-All-trans-retinal
9.52	Single	8A6E	All-trans-retinal	8A6E-Rhodopsin-All-trans-retinal
9.52	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
9.52	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
9.52	Consensus	smo_on_allo	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.30	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
9.09	Single	3OAX	11-cis-Retinal	3OAX-Rhodopsin-11-cis-Retinal
9.09	Single	6A94	Zotepine	6A94-5-HT_2A-Zotepine
9.09	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
9.09	Single	7EJA	Dexmedetomidine	7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
9.09	Single	7EJX	(1R;2R)-2-PCCA	7EJX-GPR88-(1R;2R)-2-PCCA-Gi1/&β;1/&γ;2
9.09	Single	7VVO	PTH	7VVO-PTH1-PTH-Gs/&β;1/&γ;2
9.09	Single	7ZBC	11-cis-Retinal	7ZBC-Rhodopsin-11-cis-Retinal
9.09	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6WH4-5-HT_2A-Methiothepin 7VOE-5-HT_2A-Aripiprazole 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 6A93-5-HT_2A-Risperidone
8.70	Single	1HZX	11-cis-Retinal	1HZX-Rhodopsin-11-cis-Retinal
8.70	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
8.70	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
8.70	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
8.70	Single	8J18	(3R)-3-hydroxydodecanoic acid	8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
8.70	Single	8JPF	PubChem 118610427	8JPF-NTS₁-Neurotensin-PubChem 118610427
8.70	Single	8JR9	PCO371	8JR9-PTH1-PCO371-chim(NtGi1-Gs)/&β;1/&γ;2
8.70	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
8.70	Single	8X63	Mepyramine	8X63-H₁-Mepyramine
8.70	Single	8X64	Desloratadine	8X64-H₁-Desloratadine
8.33	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
8.33	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
8.33	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
8.33	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
8.33	Single	7TRK	Iperoxo	7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2
8.33	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
8.33	Single	8E9Z	Iperoxo	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33	Single	8EA0	Iperoxo	8EA0-M₃-Iperoxo
8.33	Single	8GW8	KHF	8GW8-PTH1-KHF-Gs/&β;1/&γ;2
8.33	Single	8JPC	PubChem 118610427; GDP; Mg	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.33	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
8.33	Consensus	alpha2a_on	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
8.33	Consensus	gq_muscarinic	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
8.33	Consensus	m1_on	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
8.11	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
8.00	Single	5V54	Methiothepin	5V54-5-HT_1B-Methiothepin
8.00	Single	6OIJ	Iperoxo	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
8.00	Single	7EW4	CYM5541	7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2
8.00	Single	7EW7	PubChem 4077460	7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
8.00	Single	7TRQ	Iperoxo	7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
8.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00	Consensus	5ht1_off	Orthosteric Ligand	5ht1b_off
8.00	Consensus	5ht1b_off	Orthosteric Ligand	5V54-5-HT_1B-Methiothepin
8.00	Consensus	go_adrenergic	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
8.00	Consensus	h1_off	Orthosteric Ligand	3RZE-H₁-Cidoxepin 8X5Y-H₁-Astemizole 8X63-H₁-Mepyramine 8X64-H₁-Desloratadine
8.00	Consensus	histamine_off	Orthosteric Ligand	h1_off
7.69	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
7.69	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
7.69	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
7.69	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.69	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
7.69	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
7.69	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
7.69	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/&β;1/&γ;2
7.69	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
7.69	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
7.69	Single	8TB7	PubChem 168510218	8TB7-GPR61-PubChem 168510218
7.69	Consensus	gpr119_on	Orthosteric Ligand	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
7.69	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
7.41	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
7.41	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
7.41	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
7.41	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
7.41	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2
7.41	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
7.41	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
7.14	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
7.14	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
7.14	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
6.90	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
6.90	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
6.67	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
6.67	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
6.45	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
6.45	Consensus	gi_formylpeptide	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
6.25	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Single	4A4M	All-trans-retinal	4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
5.88	Single	5EN0	All-trans-retinal	5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
5.88	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
5.71	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
5.71	Consensus	go_class-b1	Orthosteric Ligand	go_crf
5.71	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
5.56	Single	3PXO	All-trans-retinal	3PXO-Rhodopsin-All-trans-retinal
5.56	Single	5DYS	All-trans-retinal	5DYS-Rhodopsin-All-trans-retinal
5.56	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
5.56	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.56	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
5.41	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
5.41	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
5.41	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
5.41	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Single	2HPY	All-trans-retinal	2HPY-Rhodopsin-All-trans-retinal
5.26	Single	6OY9	All-trans-retinal	6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.26	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26	Single	8WC5	Tetramethylammonium ion	8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	sensory_on	Orthosteric Ligand	opsin_on
5.13	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
5.00	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
5.00	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
5.00	Single	3C9M	11-cis-Retinal	3C9M-Rhodopsin-11-cis-Retinal
5.00	Single	3PQR	All-trans-retinal	3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
5.00	Single	5WKT	Octyl Beta-D-Glucopyranoside	5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
5.00	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
5.00	Single	7MT8	All-trans-retinal	7MT8-Rhodopsin-All-trans-retinal-GRK1
5.00	Single	7MT9	All-trans-retinal	7MT9-Rhodopsin-All-trans-retinal-GRK1
5.00	Single	7MTA	All-trans-retinal	7MTA-Rhodopsin-All-trans-retinal-GRK1
5.00	Single	8IU2	Retinal	8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
5.00	Single	8POK	Histamine	8POK-H₂-Histamine-Gs/&β;1/&γ;2
5.00	Consensus	adgrg3_on	Orthosteric Ligand	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.00	Consensus	opsin_on	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
4.76	Single	1L9H	11-cis-Retinal	1L9H-Rhodopsin-11-cis-Retinal
4.76	Single	1U19	11-cis-Retinal	1U19-Rhodopsin-11-cis-Retinal
4.76	Single	2G87	All-trans-retinal	2G87-Rhodopsin-All-trans-retinal
4.76	Single	2I35	11-cis-Retinal	2I35-Rhodopsin-11-cis-Retinal
4.76	Single	3AYM	All-trans-retinal	3AYM-Rhodopsin-All-trans-retinal
4.76	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
4.76	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
4.76	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
4.76	Single	6I9K	9-cis-Retinal	6I9K-Rhodopsin-9-cis-Retinal
4.76	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
4.76	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
4.76	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.76	Single	7YFC	Histamine	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	7YFD	Imetit	7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8HN8	Histamine	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2
4.76	Single	8ITF	DMCHA	8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.76	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
4.76	Single	8W8B	SEP-363856	8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2
4.76	Single	8WC3	SEP-363856	8WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Consensus	go_adhesion	Orthosteric Ligand	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
4.76	Consensus	go_class-b2	Orthosteric Ligand	go_adhesion
4.76	Consensus	mt1_on	Orthosteric Ligand	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
4.55	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
4.55	Single	1GZM	11-cis-Retinal	1GZM-Rhodopsin-11-cis-Retinal
4.55	Single	2PED	9-cis-Retinal	2PED-Rhodopsin-9-cis-Retinal
4.55	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
4.55	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
4.55	Single	3C9L	11-cis-Retinal	3C9L-Rhodopsin-11-cis-Retinal
4.55	Single	3VG9	ZM241385	3VG9-A_2A-ZM241385-Antibody
4.55	Single	6B73	PubChem 131955138	6B73-κ-PubChem 131955138
4.55	Single	6C1Q	NDT9513727	6C1Q-C5a₁-PMX53-NDT9513727
4.55	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
4.55	Single	6KUY	PubChem 145704643	6KUY-α_2a-PubChem 145704643
4.55	Single	6NWE	Octyl Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
4.55	Single	6OYA	All-trans-retinal	6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
4.55	Single	6TQ6	PubChem 145714283	6TQ6-OX₁-PubChem 145714283
4.55	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.55	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.55	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.55	Single	7T6S	PubChem 24776341	7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
4.55	Single	7T8X	Acetylcholine	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
4.55	Single	7T90	Acetylcholine	7T90-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
4.55	Single	7YM8	Oxymetazoline	7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
4.55	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
4.55	Single	8HOC	Imetit	8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
4.55	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.55	Single	8U8F	PML	8U8F-GPR3-PML-Gs/&β;1/&γ;2
4.55	Consensus	a2a_off_allo	Orthosteric Ligand	6ZDR-A_2A-HMS1413f12-Na 6GT3-A_2A-Imaradenant-Na 8CU7-A_2A-LJ-4517-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PubChem 92460631; psb36-Na 5MZJ-A_2A-Theophylline-Na 5OLO-A_2A-Tozadenant-Na 5OLH-A_2A-Vipadenant-Na 5NM4-A_2A-ZM241385-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5MZP-A_2A-Caffeine-Na 8CIC-A_2A-Etrumadenant-Na
4.55	Consensus	alpha1_on	Orthosteric Ligand	alpha1a_on
4.55	Consensus	alpha1a_on	Orthosteric Ligand	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55	Consensus	gi_histamine	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2 8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
4.55	Consensus	gs_histamine	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Consensus	gt_class-a	Orthosteric Ligand	gt_opsin
4.55	Consensus	gt_opsin	Orthosteric Ligand	gt_sensory
4.55	Consensus	gt_sensory	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
4.55	Consensus	h4_on	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Consensus	m2_on	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
4.55	Consensus	melatonin_on	Orthosteric Ligand	mt1_on mt2_on
4.55	Consensus	mglu_on	Other Ligand	mglu2_on mglu4_on
4.55	Consensus	nts1_on_allo	Other Ligand	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.55	Consensus	opsin_off	Orthosteric Ligand	1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
4.44	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
4.35	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
4.35	Single	3RZE	Cidoxepin	3RZE-H₁-Cidoxepin
4.35	Single	3UZC	PubChem 135566609	3UZC-A_2A-PubChem 135566609
4.35	Single	4DKL	Beta-funaltrexamine	4DKL-μ-Beta-funaltrexamine
4.35	Single	4MQT	Iperoxo	4MQT-M₂-Iperoxo-LY2119620
4.35	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
4.35	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
4.35	Single	5JTB	ZM241385	5JTB-A_2A-ZM241385
4.35	Single	5K2B	ZM241385	5K2B-A_2A-ZM241385-Na
4.35	Single	5TE3	Octyl Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
4.35	Single	5UVI	ZM241385	5UVI-A_2A-ZM241385
4.35	Single	6AQF	ZM241385	6AQF-A_2A-ZM241385
4.35	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
4.35	Single	6K41	Dexmedetomidine	6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2
4.35	Single	6MH8	ZM241385	6MH8-A_2A-ZM241385
4.35	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
4.35	Single	6TPK	Retosiban	6TPK-OT-Retosiban
4.35	Single	6TPN	HTL6641	6TPN-OX₂-HTL6641
4.35	Single	6WH4	Methiothepin	6WH4-5-HT_2A-Methiothepin
4.35	Single	6WJC	Atropine	6WJC-M₁-Atropine-Muscarinic toxin 7
4.35	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
4.35	Single	6ZG9	GSK1034702	6ZG9-M₁-GSK1034702
4.35	Single	7CMV	PD128907	7CMV-D₃-PD128907-Gi1/&β;1/&γ;2
4.35	Single	7E33	BRL-54443	7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2
4.35	Single	7EJ8	Brimonidine	7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2
4.35	Single	7T32	ZM241385	7T32-A_2A-ZM241385
4.35	Single	7T94	Acetylcholine	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
4.35	Single	7TRS	Acetylcholine	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2
4.35	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
4.35	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
4.35	Single	7ZBE	11-cis-Retinal	7ZBE-Rhodopsin-11-cis-Retinal
4.35	Single	8FCZ	11-cis-Retinal	8FCZ-Rhodopsin-11-cis-Retinal
4.35	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35	Single	8HNM	VUF11222	8HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
4.35	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	8JLN	T1AM	8JLN-TA1-T1AM-Gs/&β;1/&γ;2
4.35	Single	8JSP	Ulotaront	8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2
4.35	Single	8THK	A61603	8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35	Single	8THL	Epinephrine	8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/&β;1/&γ;2
4.35	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2
4.35	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.35	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35	Consensus	5ht1e_on	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2
4.35	Consensus	5ht2a_on	Orthosteric Ligand	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35	Consensus	alpha2b_on	Orthosteric Ligand	6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2
4.35	Consensus	dop_off_allo	Orthosteric Ligand	4N6H-δ-Naltrindole-Na
4.35	Consensus	ghrelin_off	Orthosteric Ligand	6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
4.35	Consensus	gi_melatonin	Orthosteric Ligand	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
4.35	Consensus	m1_off_allo	Orthosteric Ligand	6WJC-M₁-Atropine-Muscarinic toxin 7
4.35	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
4.35	Consensus	sensory_off	Orthosteric Ligand	opsin_off
4.35	Consensus	vasopressin-ot_off	Orthosteric Ligand	ot_off
4.17	Single	3EML	ZM241385	3EML-A_2A-ZM241385
4.17	Single	3NY8	ICI 118-551	3NY8-β₂-ICI 118-551
4.17	Single	3NYA	(S)-Alprenolol	3NYA-β₂-(S)-Alprenolol
4.17	Single	3ZPQ	4-(piperazin-1- yl)-1H-indole	3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na
4.17	Single	3ZPR	4-methyl-2-(piperazin-1-yl)	3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
4.17	Single	4DAJ	Tiotropium	4DAJ-M₃-Tiotropium
4.17	Single	4EIY	ZM241385	4EIY-A_2A-ZM241385-Na
4.17	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
4.17	Single	4GBR	(S)-Carazolol	4GBR-β₂-(S)-Carazolol
4.17	Single	4MQS	Iperoxo	4MQS-M₂-Iperoxo
4.17	Single	4U14	Tiotropium	4U14-M₃-Tiotropium
4.17	Single	4U16	N-Methyl Scopolamine	4U16-M₃-N-Methyl Scopolamine
4.17	Single	4X1H	Nonyl Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
4.17	Single	5DSG	Tiotropium	5DSG-M₄-Tiotropium
4.17	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
4.17	Single	5K2A	ZM241385	5K2A-A_2A-ZM241385-Na
4.17	Single	5OLG	ZM241385	5OLG-A_2A-ZM241385-Na
4.17	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
4.17	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
4.17	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
4.17	Single	5VRA	ZM241385	5VRA-A_2A-ZM241385-Na
4.17	Single	5YC8	N-Methyl Scopolamine	5YC8-M₂-N-Methyl Scopolamine
4.17	Single	5ZK8	N-Methyl Scopolamine	5ZK8-M₂-N-Methyl Scopolamine
4.17	Single	5ZKC	N-Methyl Scopolamine	5ZKC-M₂-N-Methyl Scopolamine
4.17	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
4.17	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
4.17	Single	6IIV	Daltroban	6IIV-TP-Daltroban
4.17	Single	6K42	Dexmedetomidine	6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
4.17	Single	6PS0	(S)-Carazolol	6PS0-β₂-(S)-Carazolol
4.17	Single	6PS2	(S)-Alprenolol	6PS2-β₂-(S)-Alprenolol
4.17	Single	6S0L	ZM241385	6S0L-A_2A-ZM241385
4.17	Single	6WHA	DB13948	6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
4.17	Single	7E32	Serotonin	7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2
4.17	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
4.17	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
4.17	Single	7TRP	Iperoxo	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
4.17	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
4.17	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
4.17	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
4.17	Single	7WC7	Lisuride	7WC7-5-HT_2A-Lisuride
4.17	Single	7XTC	5-CT	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
4.17	Single	8CIC	Etrumadenant	8CIC-A_2A-Etrumadenant-Na
4.17	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
4.17	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
4.17	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
4.17	Single	8JJO	Alprenolol	8JJO-β₂-Alprenolol
4.17	Single	8JLJ	T1AM	8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
4.17	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
4.17	Consensus	5ht1d_on	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2
4.17	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
4.17	Consensus	5ht7_on	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
4.17	Consensus	a2_off	Orthosteric Ligand	a2a_off
4.17	Consensus	a2a_off	Orthosteric Ligand	8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 5UIG-A_2A-J3.651.884G 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-PubChem 168451710 5K2D-A_2A-ZM241385
4.17	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on
4.17	Consensus	alpha2_on	Orthosteric Ligand	alpha2a_on alpha2b_on
4.17	Consensus	alpha_on	Orthosteric Ligand	alpha1_on alpha2_on
4.17	Consensus	amine_on	Orthosteric Ligand	adrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
4.17	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
4.17	Consensus	blt_on	Orthosteric Ligand	blt1_on
4.17	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
4.17	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
4.17	Consensus	go_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
4.17	Consensus	gq_amine	Orthosteric Ligand	gq_muscarinic gq_histamine
4.17	Consensus	histamine_on	Orthosteric Ligand	h1_on h4_on
4.17	Consensus	leuko_on	Orthosteric Ligand	blt_on
4.17	Consensus	m2_on_allo	Orthosteric Ligand	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
4.17	Consensus	m4_off	Orthosteric Ligand	5DSG-M₄-Tiotropium
4.17	Consensus	m4_on_allo	Orthosteric Ligand	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
4.17	Consensus	muscarinic_on	Orthosteric Ligand	m2_on m3_on m4_on m1_on
4.17	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on
4.17	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
4.17	Consensus	tar_on	Orthosteric Ligand	ta1_on
4.17	Consensus	tp_off	Orthosteric Ligand	6IIV-TP-Daltroban 6IIU-TP-Ramatroban
4.00	Single	2RH1	(S)-Carazolol	2RH1-β₂-(S)-Carazolol
4.00	Single	2YCW	(S)-Carazolol	2YCW-β₁-(S)-Carazolol
4.00	Single	4WW3	All-trans-retinal	4WW3-Rhodopsin-All-trans-retinal
4.00	Single	5D6L	(S)-Carazolol	5D6L-β₂-(S)-Carazolol
4.00	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
4.00	Single	5N2R	PubChem 92460631; psb36	5N2R-A_2A-PubChem 92460631; psb36-Na
4.00	Single	5N2S	PSB36	5N2S-A₁-PSB36
4.00	Single	5NM2	ZM241385	5NM2-A_2A-ZM241385-Na
4.00	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
4.00	Single	5X7D	(S)-Carazolol	5X7D-β₂-(S)-Carazolol-PubChem 129318963
4.00	Single	5XPR	Bosentan	5XPR-ET_B-Bosentan
4.00	Single	5ZK3	Quinuclidinyl benzilate hydrobromide	5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
4.00	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
4.00	Single	6LFL	PubChem 153466996	6LFL-CXCR2-PubChem 153466996
4.00	Single	6LPL	ZM241385	6LPL-A_2A-ZM241385-Na
4.00	Single	6OIK	Iperoxo	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
4.00	Single	6PS6	Timolol	6PS6-β₂-Timolol
4.00	Single	6S0Q	ZM241385	6S0Q-A_2A-ZM241385
4.00	Single	6WQA	ZM241385	6WQA-A_2A-ZM241385-Na
4.00	Single	7C4S	S1P	7C4S-S1P₃-S1P
4.00	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
4.00	Single	7RM5	ZM241385	7RM5-A_2A-ZM241385-Na
4.00	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
4.00	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
4.00	Single	8EFB	Oliceridine	8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
4.00	Single	8FN0	PubChem 118610427	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
4.00	Single	8FYN	ZM241385	8FYN-A_2A-ZM241385-Na
4.00	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
4.00	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
4.00	Single	8J19	PubChem 127045422	8J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
4.00	Single	8QOT	Nanobody E	8QOT-μ-Nanobody E
4.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
4.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00	Consensus	5ht1_on	Orthosteric Ligand	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
4.00	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
4.00	Consensus	a2a_on	Orthosteric Ligand	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
4.00	Consensus	amine_off	Orthosteric Ligand	adrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
4.00	Consensus	beta2_off	Orthosteric Ligand	6PS2-β₂-(S)-Alprenolol 6PS3-β₂-(S)-Carvedilol 6PS5-β₂-(S)-Propranolol 6PS6-β₂-Timolol 2RH1-β₂-(S)-Carazolol 6PS4-β₂-ICI 118-551 3NY9-β₂-PubChem 913103
4.00	Consensus	beta_off	Orthosteric Ligand	beta1_off beta2_off
4.00	Consensus	ep3_on	Orthosteric Ligand	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
4.00	Consensus	go_amine	Orthosteric Ligand	go_adrenergic go_muscarinic go_5ht
4.00	Consensus	gs_muscarinic	Orthosteric Ligand	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00	Consensus	m2_off	Orthosteric Ligand	5ZKB-M₂-AF-DX 384 5ZKC-M₂-N-Methyl Scopolamine 5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
4.00	Consensus	m3_on	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	2YDV	NECA	2YDV-A_2A-NECA
3.85	Single	3UON	Quinuclidinyl benzilate hydrobromide	3UON-M₂-Quinuclidinyl benzilate hydrobromide
3.85	Single	4DJH	JDTic	4DJH-κ-JDTic
3.85	Single	4U15	Tiotropium	4U15-M₃-Tiotropium
3.85	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
3.85	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
3.85	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
3.85	Single	5D5A	(S)-Carazolol	5D5A-β₂-(S)-Carazolol
3.85	Single	5D5B	(S)-Carazolol	5D5B-β₂-(S)-Carazolol
3.85	Single	5G53	NECA	5G53-A_2A-NECA-Gs
3.85	Single	5X93	K-8794	5X93-ET_B-K-8794
3.85	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
3.85	Single	5ZKB	AF-DX 384	5ZKB-M₂-AF-DX 384
3.85	Single	6E59	L-760735	6E59-NK₁-L-760735
3.85	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
3.85	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
3.85	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
3.85	Single	6OL9	Tiotropium	6OL9-M₅-Tiotropium
3.85	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
3.85	Single	7EPE	NAM563	7EPE-mGlu-NAM563
3.85	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
3.85	Single	7FEE	PubMed 104895	7FEE-CB₁-PubMed 104895-ZCZ011
3.85	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
3.85	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
3.85	Single	7U2L	PubChem 163201242	7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
3.85	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2
3.85	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
3.85	Single	7W41	PD176252	7W41-BB₂-PD176252
3.85	Single	7W6P	W96	7W6P-α_2a-W96-Go/&β;1/&γ;2
3.85	Single	7W7E	W58	7W7E-α_2a-W58-Go/&β;1/&γ;2
3.85	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
3.85	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/&β;1/&γ;2
3.85	Single	8EF5	Fentanyl	8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
3.85	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
3.85	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2
3.85	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
3.85	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2
3.85	Single	8JD0	J9R	8JD0-mGlu2; mGlu3-Glutamate-J9R
3.85	Single	8JPB	PubChem 118610427; GDP; Mg	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
3.85	Single	8JXX	Clobenpropit	8JXX-H₄-Clobenpropit-Gi1/&β;1/&γ;2
3.85	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
3.85	Single	8X16	Piclidenoson	8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
3.85	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/&β;1/&γ;2
3.85	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
3.85	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
3.85	Consensus	5ht1b_on	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
3.85	Consensus	5ht_off	Orthosteric Ligand	5ht2_off 5ht5_off 5ht1_off
3.85	Consensus	a2_on	Orthosteric Ligand	a2a_on a2b_on
3.85	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
3.85	Consensus	angiotensin_off	Orthosteric Ligand	at1_off at2_off
3.85	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
3.85	Consensus	beta1_off	Orthosteric Ligand	2VT4-β₁-Cyanopindolol 2YCZ-β₁-Iodocyanopindolol
3.85	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
3.85	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
3.85	Consensus	dopamine_off	Orthosteric Ligand	d3_off d2_off d4_off
3.85	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
3.85	Consensus	gi_muscarinic	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
3.85	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A_2A-NECA-Gs/&β;1/&γ;1 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
3.85	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
3.85	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
3.85	Consensus	m3_off	Orthosteric Ligand	4U15-M₃-Tiotropium 4U16-M₃-N-Methyl Scopolamine 5ZHP-M₃-PubChem 134828589
3.85	Consensus	m5_off	Orthosteric Ligand	6OL9-M₅-Tiotropium
3.85	Consensus	mglu2_on	Other Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.85	Consensus	muscarinic_off	Orthosteric Ligand	m2_off m3_off m4_off m5_off m1_off
3.85	Consensus	nk1_off	Orthosteric Ligand	6J20-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
3.85	Consensus	s1p2_on	Orthosteric Ligand	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
3.85	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
3.70	Single	3D4S	Timolol Maleate	3D4S-β₂-Timolol Maleate
3.70	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
3.70	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
3.70	Single	5CXV	Tiotropium	5CXV-M₁-Tiotropium
3.70	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
3.70	Single	5LWE	Vercirnon	5LWE-CCR9-Vercirnon
3.70	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
3.70	Single	6H7N	(S)-Xamoterol	6H7N-β₁-(S)-Xamoterol
3.70	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
3.70	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
3.70	Single	6IIU	Ramatroban	6IIU-TP-Ramatroban
3.70	Single	6KQI	PubMed 104895	6KQI-CB₁-PubMed 104895-ORG27569
3.70	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
3.70	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
3.70	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2
3.70	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
3.70	Single	7JNI	Olodanrigan	7JNI-AT₂-Olodanrigan
3.70	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
3.70	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
3.70	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
3.70	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
3.70	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
3.70	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
3.70	Single	8JWY	PubChem 168451710	8JWY-A_2A-PubChem 168451710
3.70	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
3.70	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
3.70	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg3_on
3.70	Consensus	at2_off	Orthosteric Ligand	7JNI-AT₂-Olodanrigan
3.70	Consensus	blt1_off	Orthosteric Ligand	7K15-BLT₁-MKD046-Na
3.70	Consensus	blt_off	Orthosteric Ligand	blt1_off
3.70	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
3.70	Consensus	cb1_off_allo	Orthosteric Ligand	6KQI-CB₁-PubMed 104895-ORG27569
3.70	Consensus	ccr9_off_allo	Other Ligand	5LWE-CCR9-Vercirnon
3.70	Consensus	class-b2_on	Orthosteric Ligand	adgrg_on
3.70	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
3.70	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
3.70	Consensus	leuko_off	Orthosteric Ligand	blt_off cyslt_off
3.70	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
3.70	Consensus	m1_off	Orthosteric Ligand	5CXV-M₁-Tiotropium
3.70	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
3.70	Consensus	opioid_off	Orthosteric Ligand	kop_off mop_off nop_off dop_off
3.70	Consensus	peptide_off	Orthosteric Ligand	opioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
3.57	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
3.57	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
3.57	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
3.57	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
3.57	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
3.57	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
3.57	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2
3.57	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
3.57	Single	7EZC	UKA	7EZC-A_2A-UKA
3.57	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
3.57	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
3.57	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2
3.57	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/&β;1/&γ;2
3.57	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
3.57	Single	8E9Y	PubChem 446603	8E9Y-M₃-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.57	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
3.57	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2
3.57	Single	8ID8	TUG-891	8ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
3.57	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
3.57	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.57	Single	8XJO	U46619	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57	Consensus	adgrg2_on	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Consensus	beta1_off_allo	Orthosteric Ligand	4BVN-β₁-Cyanopindolol-Na
3.57	Consensus	endothelin_off	Orthosteric Ligand	etb_off
3.57	Consensus	ep2_on	Orthosteric Ligand	7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2
3.57	Consensus	etb_off	Orthosteric Ligand	5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500 5X93-ET_B-K-8794
3.57	Consensus	ffa4_on_allo	Orthosteric Ligand	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.57	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
3.45	Single	3NY9	PubChem 913103	3NY9-β₂-PubChem 913103
3.45	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
3.45	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
3.45	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
3.45	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
3.45	Single	6PT3	DPI-287	6PT3-δ-DPI-287
3.45	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
3.45	Single	7XY6	PubChem 11717831	7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
3.45	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
3.45	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
3.45	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
3.45	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
3.45	Consensus	gs_adgr	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
3.45	Consensus	gs_class-b2	Orthosteric Ligand	gs_adgr
3.45	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
3.45	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
3.33	Single	4AMJ	(S)-Carvedilol	4AMJ-β₁-(S)-Carvedilol
3.33	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2
3.33	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
3.33	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
3.33	Single	8G59	TUG-891	8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
3.33	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
3.33	Consensus	fpr-alx_on	Orthosteric Ligand	fpr1-alx_on fpr2-alx_on
3.33	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
3.33	Consensus	mop_off	Orthosteric Ligand	7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
3.23	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
3.23	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
3.23	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
3.12	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
3.12	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
3.12	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
3.12	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
3.12	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
3.03	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
3.03	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
3.03	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
3.03	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
2.94	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
2.94	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
2.94	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
2.94	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
2.94	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
2.94	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.94	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.94	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
2.94	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.94	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
2.94	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
2.86	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
2.86	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
2.86	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/&β;1/&γ;2
2.86	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
2.86	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
2.86	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
2.86	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
2.86	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
2.86	Consensus	ghrh_on	Orthosteric Ligand	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
2.86	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
2.78	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
2.78	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
2.78	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
2.78	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
2.78	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
2.78	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
2.78	Consensus	etb_on	Orthosteric Ligand	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
2.78	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
2.70	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
2.70	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
2.70	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
2.70	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
2.70	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
2.70	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
2.70	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
2.70	Consensus	crf1_on	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
2.70	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
2.70	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
2.70	Consensus	gs_endothelin	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.70	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
2.70	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
2.63	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
2.63	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
2.63	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
2.63	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
2.63	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
2.63	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
2.63	Consensus	gs_crf	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
2.56	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
2.56	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
2.56	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
2.56	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
2.56	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
2.56	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
2.50	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
2.50	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
2.50	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
2.50	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
2.44	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
2.44	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
2.44	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
2.38	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
2.33	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
2.27	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
2.27	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
2.22	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
2.13	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf

PDB Summary
PDB	8GTM
Class	B1
SubFamily	Peptide
Type	Corticotropin Releasing Factor
SubType	CRF1
Species	Homo sapiens
Ligand	-
Other Ligand(s)	BMK-C203
Protein Partners	-
PDB Resolution	2.6
Date	2023-09-13
D.O.I.	10.1038/s12276-023-01082-1

Net Summary
I_min	2.77
Number of Linked Nodes	244
Number of Links	278
Number of Hubs	37
Number of Links mediated by Hubs	138
Number of Communities	6
Number of Nodes involved in Communities	59
Number of Links involved in Communities	85

Path Summary
Number Of Nodes in MetaPath	86
Number Of Links MetaPath	85
Number of Shortest Paths	44241
Length Of Smallest Path	3
Average Path Length	12.8718
Length of Longest Path	31
Minimum Path Strength	1.17
Average Path Strength	6.37623
Maximum Path Strength	33.715
Minimum Path Correlation	0.7
Average Path Correlation	0.934413
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	50.7095
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.4779
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	0VI
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	0VI
Name	7-(4-bromanyl-2,6-dimethoxy-phenyl)-4,8-dimethyl-~{N},~{N}-bis[4,4,4-tris(fluoranyl)butyl]-1$l^{4},3,5,9-tetrazabicyclo[4.3.0]nona-1(6),2,4,8-tetraen-2-amine
Synonyms
Identifier	7-(4-bromanyl-2,6-dimethoxy-phenyl)-4,8-dimethyl-~{N},~{N}-bis[4,4,4-tris(fluoranyl)butyl]-1$l^{4},3,5,9-tetrazabicyclo[4.3.0]nona-1(6),2,4,8-tetraen-2-amine
Formula	C23 H27 Br F6 N5 O2
Molecular Weight	599.387
SMILES	CC1=N[N]2=C(C1c3c(cc(cc3OC)Br)OC)N=C(N=C2N(CCCC(F)(F)F)CCCC(F)(F)F)C
PubChem	168477862
Formal Charge	0
Total Atoms	64
Total Chiral Atoms	1
Total Bonds	66
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P34998-2
Sequence	>8GTM_Chain_R M E I L N E E K K S K V H Y H V A A I I N Y L G H C I S L V A L L V A F V L F L R A R S I R C L R N I I H A N L I A A F I L R N A T W F V V Q L T M S P E V H Q S N V G W C R L V T A A Y N Y F H V T N F F W M F G E G C Y L H T A I V L T D R L R A W M F I C I G W G V P F P I I V A W A I G K L Y Y D N E K C W A G K R P G V Y T D Y I Y Q G P M A L V L L I N F I F L F N I V R I L M T K L R A S T T S E T I Q A R K A V K A T L V L L P L L G I T Y M L A F V N P G E D E V S R V V F I Y F N A F L E S F Q G F F V S V F A C F L N S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4K5Y	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	-	CP-376395	-	2.98	2013-07-17	10.1038/nature12357
	4Z9G	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	-	CP-376395	-	3.18	2016-06-29	10.2174/1874467210666170110114727
	6P9X	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	Corticoliberin	-	Gs/&β;1/&γ;2	2.91	2020-02-05	10.1016/j.molcel.2020.01.012
	6PB0	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	Urocortin	-	chim(NtGi1-Gs)/&β;1/&γ;2	3	2020-02-12	10.1016/j.molcel.2020.01.013
	8GTG	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	-	BMK-I152	-	2.75	2023-09-13	10.1038/s12276-023-01082-1
	8GTI	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	-	BMK-C205	-	2.2	2023-09-13	10.1038/s12276-023-01082-1

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