Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x31 2.2847502
21x39 4.46838417
31x50 5.57596419
41x60 2.711027126
52x42 5.0475508
62x50 5.59963519
72x53 4.48458407
82x63 5.87212415
9E1x50 6.92847618
103x29 4.44167515
113x32 5.23233418
123x37 3.74604408
133x50 6.95787519
143x51 7.552044148
15I2x51 3.193634157
16I2x52 4.07258405
174x50 5.10967419
184x57 4.68871408
19E2 16.22651513
20E2x50 6.78287419
215x39 4.54121417
225x47 8.37654408
235x58 5.03514619
246x31 2.45425406
256x44 3.77413419
266x48 4.989918
276x51 5.08746417
286x52 7.56037407
29E3 4.185221013
307x34 4.02923514
317x38 4.75493515
327x42 3.85613817
337x45 6.89242419
347x49 5.53512419
357x53 5.28604419
367x54 2.29704407
378x50 4.09875408
38b.1x1 2.09275404
39b.h2x1 3.61446405
40b.lhb1x6 3.033174163
41b.b1x3 4.16283447
42b.l1x3 8.4644549
43b.b2x1 7.7534528
44b.b2x5 8.11671407
45b.b3x3 3.85417508
46b.l3x1 5.9735429
47b.b4x3 3.90388407
48b.b4x5 4.726754187
49b.b4x6 8.90407749
50b.b5x2 6.1385407
51b.b5x3 7.34893549
52b.b5x5 5.585084185
53b.b5x7 5.74204407
54b.l5x1 4.32562408
55b.l5x5 6.50231829
56b.b6x5 3.9771506
57b.b7x1 6.44729404
58b.l7x2 4.607429
59b.b8x4 5.84967506
60b.b8x5 5.652634204
61b.l9x3 9.01113429
62b.l9x6 5.11963928
63b.b10x5 4.48913509
64b.l10x1 3.74525403
65b.b11x4 5.19729429
66b.b11x5 4.70138436
67b.l11x2 7.52579429
68b.b12x3 4.04254438
69b.b12x6 8.58122628
70b.b13x7 8.1806537
71b.l13x3 6.15602739
72b.l13x6 4.48027529
73b.b14x3 4.84921435
74b.b15x1 7.63608439
75b.l15x1 5.23196427
76b.l15x2 6.02277539
77b.b16x4 8.02893536
78b.b16x6 8.16136638
79b.b17x5 6.01233457
80b.b17x7 8.40112458
81b.l17x3 8.65186659
82b.l17x6 8.74646429
83b.b18x3 5.31671458
84b.l18x1 5.73317776
85b.l18x2 5.66958477
86b.l18x3 6.42617475
87b.b19x2 8.07627556
88b.b19x4 6.30587458
89b.l19x1 5.51908429
90b.l19x2 7.26683409
91b.b20x2 4.56163556
92b.b20x4 7.80544658
93b.b20x6 7.78917556
94b.b21x1 6.9039557
95b.b21x7 4.83576705
96b.l21x2 4.03793504
97b.l22x5 7.120464169
98b.b23x2 5.15529406
99b.b23x6 6.48156697
100b.l23x1 8.39363406
101b.l23x2 5.04654498
102b.b24x4 6.16829496
103b.b24x6 7.28533498
104b.l25x3 11.818489
105b.l26x1 6.869044177
106b.l27x1 10.1395829
107b.l27x2 8.66221489
108b.b28x3 4.7878547
109b.b28x4 8.89071486
110b.b28x6 8.43167589
111g.h1x8 2.09942407
112g.h2x11 9.63279476
113g.ctx3 5.9525509
114g.ctx6 2.89937406
115g.ctx14 5.37958449
116g.ctx15 6.49792449
117g.ctx16 4.96107948
118G.HN.11 1.76857502
119G.S1.06 4.32767468
120G.H1.01 2.87636669
121G.H1.04 7.41112467
122G.H1.09 2.18429407
123G.H1.12 3.54446408
124G.S2.04 6.2168567
125G.S2.06 3.84213508
126G.S2.08 2.53496405
127G.S3.03 4.17413507
128G.S3.04 8.39229407
129G.S3.05 4.90146467
130G.S3.07 4.4558569
131G.s3h2.03 5.32971429
132G.H2.06 5.65586729
133G.H2.07 5.52931729
134G.H2.09 5.70537428
135G.H2.10 3.8236527
136G.h2s4.01 6.37193529
137G.h2s4.02 4.54033427
138G.S4.03 3.98497567
139G.S4.04 6.75737429
140G.s4h3.03 6.06025407
141G.s4h3.04 6.039726118
142G.s4h3.05 6.912674119
143G.H3.01 8.46146409
144G.H3.06 5.04921407
145G.H3.09 6.63683409
146G.H3.15 3.44953528
147G.H3.17 5.18913525
148G.H3.18 5.37842429
149G.S5.03 4.09713468
150G.S5.05 3.82554869
151G.s5hg.01 3.16333409
152G.hgh4.02 3.80143508
153G.hgh4.05 6.52946406
154G.H4.08 6.24571405
155G.H4.12 3.95438405
156G.S6.02 6.958735218
157G.s6h5.01 5.33427569
158G.s6h5.02 2.71642407
159G.H5.03 5.36867568
160G.H5.08 4.184235158
161G.H5.23 5.95347614
162Lig 6.368882010
163NT 6.00125410
164I3 1.91233500
165G.s4h3.08 1.57396400
166CT 2.6015490
167H.HA.13 0.402167400
168H.HA.16 0.6714500
169H.HE.02 0.613667400
170H.hahb.06 0.823400
171H.HB.10 0.713917400
172H.hchd.01 0.663500
173H.HD.07 1.01633400
174H.HE.09 0.2455400
175H.hehf.04 0.7064500
176I1 4.114130
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
16x48 Lig 37.81613.70067YesYes180
26x44 6x48 42.14234.45983YesYes198
35x54 6x44 53.86933.52767NoYes189
4G.H5.22 G.H5.23 11.74.30217NoYes144
52x37 G.H5.22 11.41113.942NoNo074
62x37 2x40 11.11745.17467NoNo079
72x40 I1 10.56374.12NoYes090
83x49 G.H5.23 18.02826.53817NoYes094
93x47 5x54 52.86325.09767NoNo198
103x49 I2x57 24.43528.86167NoNo097
113x47 5x57 60.43544.03967NoNo096
123x51 5x57 60.91348.79867YesNo086
133x51 3x56 61.56553.66417YesNo1486
143x56 I2x52 62.3524.92983NoYes065
153x52 I2x52 25.41463.186NoYes055
16I2x53 I2x57 24.90494.3035NoNo077
17G.s2s3.01 I2x52 91.84954.5NoYes045
18G.H5.08 G.s2s3.01 92.07766.79367YesNo084
19G.H5.08 G.S3.03 63.95323.7515YesYes087
20G.S1.04 G.S3.03 64.82113.77383NoYes067
21G.S1.04 G.S4.01 31.31544.78NoNo068
22G.H5.08 G.S2.08 29.53413.3105YesYes085
23G.H1.12 G.S2.08 29.76453.29917YesYes085
24G.H1.12 G.S2.06 29.95546.35317YesYes088
25G.H1.08 G.S2.06 30.53973.337NoYes098
26G.H1.04 G.H1.08 30.56897.25817YesNo079
27G.H1.04 G.S4.05 29.98637.653YesNo077
28G.S4.05 G.S5.07 30.01713.93717NoNo079
29G.S5.07 G.s5hg.01 1003.93867NoYes099
30G.S4.07 G.s5hg.01 92.99633.93417NoYes089
31G.S4.07 G.s4h3.03 92.9215.30617NoYes087
32G.H3.02 G.s4h3.03 91.91673.655NoYes087
33G.H3.02 G.hgh4.02 91.84293.815NoYes088
34G.H4.14 G.hgh4.02 92.70615.59867NoYes058
35G.H3.06 G.H4.14 92.86164.968YesNo075
36G.H3.06 G.H4.15 92.63073.26533YesNo079
37G.H3.09 G.H4.15 92.45513.67983YesNo099
38G.H3.09 G.S4.04 91.563612.537YesYes099
39G.H3.08 G.S4.04 30.65713.32933NoYes099
40G.H2.04 G.H3.08 30.48783.45983NoNo099
41G.H2.04 G.H2.07 30.50765.93333NoYes099
42G.H2.07 b.l9x6 28.3747.73333YesYes298
43G.H2.06 b.l9x6 35.72583.14283YesYes298
44G.H2.06 b.l19x1 34.40383.45667YesYes299
45b.l17x5 b.l19x1 34.22753.0635NoYes069
46b.l17x5 b.l19x2 33.95456.797NoYes069
47b.b20x2 b.l19x2 28.53065.46733YesYes069
48b.b20x2 b.b20x4 23.09753.794YesYes568
49b.b20x4 b.b20x6 22.28834.79333YesYes586
50b.b17x7 b.b20x6 18.896511.7715YesYes586
51b.b17x7 b.b21x1 15.22863.66317YesYes587
52b.1x19 b.b21x1 14.15786.03567NoYes067
53b.1x15 b.1x19 11.28194.76133NoNo076
54b.1x14 b.1x15 10.7041.92133NoNo047
55b.1x11 b.1x14 10.12522.3275NoNo084
56G.S1.04 G.S3.05 33.86474.5725NoYes067
57G.S3.05 G.S4.03 29.97895.728YesYes677
58G.S4.03 G.S5.05 38.65773.29683YesYes679
59G.S5.05 G.s6h5.01 70.04443.41333YesYes699
60G.S5.07 G.s6h5.01 70.0575.1925NoYes099
61G.S4.01 G.S5.03 30.21166.08667NoYes088
62G.S5.03 G.S5.05 32.9243.244YesYes689
63G.H3.12 G.S4.04 55.42663.89483NoYes279
64G.H3.12 G.H3.15 55.41333.50833NoYes278
65G.H2.08 G.H3.15 54.49734.152NoYes288
66G.H2.08 G.H3.17 54.62373.60333NoYes285
67G.H3.17 b.l25x6 59.64583.68333YesNo258
68b.l23x1 b.l25x6 75.795820.2682YesNo068
69b.l21x7 b.l23x1 75.21285.056NoYes056
70b.l21x7 b.l23x2 74.82295.08333NoYes058
71b.b23x6 b.l23x2 73.68683.90983YesYes978
72b.b23x6 b.b24x6 71.33918.34583YesYes978
73b.b21x7 b.b24x6 70.818611.335YesYes058
74b.b21x5 b.b21x7 63.10953.95NoYes045
75b.b21x5 b.h2x1 62.06884.757NoYes045
76b.h2x1 b.h2x5 61.58412.72467YesNo055
77b.h2x5 b.l24x2 60.52983.61067NoNo056
78b.l22x5 b.l24x2 60.10657.87333YesNo096
79b.l22x5 g.ctx6 58.19053.70233YesYes096
80g.ctx3 g.ctx6 57.11816.2195YesYes096
81g.ctx3 g.ctx4 48.6364.37383YesNo097
82b.l26x5 g.ctx4 48.41215.1435NoNo057
83b.l26x5 g.ctx15 41.88935.20083NoYes059
84G.H2.09 G.H2.10 15.73973.14517YesYes287
85b.l4x2 g.ctx15 31.65610.2247NoYes449
86b.l2x5 b.l4x2 32.111121.8973NoNo054
87b.l2x3 b.l2x5 28.0922.737NoNo085
88b.b3x1 b.l2x3 27.84895.13383NoNo058
89b.b3x1 b.b6x5 27.60563.5545NoYes056
90b.b2x4 b.b6x5 14.13233.1065NoYes066
91b.b10x4 b.b2x4 13.876513.5033NoNo066
92b.b3x3 b.b6x5 13.36443.78467YesYes086
93G.H2.10 b.b6x1 22.33773.186YesNo079
94b.b6x1 b.l9x6 22.14064.99033NoYes098
95b.l11x1 b.l9x6 13.98213.5985NoYes298
96b.b11x6 b.l11x1 13.72562.8775NoNo299
97b.b11x6 b.l9x3 11.194516.3912NoYes299
98G.H1.01 G.S1.06 12.37354.418YesYes698
99G.H1.01 G.hfs2.02 11.69461.08467YesNo090
100G.hfs2.02 H.hdhe.04 11.44340.577333NoNo000
1013x52 I2x53 25.13973.5685NoNo057
102b.l25x6 b.l27x1 16.309322.34NoYes289
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
1x397x396.346331YesNo7722
2x563x326.387671NoYes7821
2x567x423.283171NoYes7721
2x577x424.6680NoYes7721
2x607x423.58151NoYes7721
2x63E1x509.171YesYes5812
2x63Lig4.77551YesYes5010
E1x49E26.564171NoYes4321
E1x50E2x5011.50531YesYes8922
3x22E212.2441NoYes4321
3x294x655.292671YesNo5612
3x29E2x525.40051YesNo5511
3x29Lig3.1421YesYes5010
3x327x424.406671YesYes8711
3x32Lig4.789671YesYes8010
3x334x577.814331NoYes6812
3x33Lig6.9981NoYes6010
3x366x483.955671NoYes7811
3x36Lig6.112671NoYes7010
4x64E28.186170NoYes4321
E2E266.30731YesYes3311
E2E2x5119.27421YesNo3411
E2Lig19.10631YesYes3010
E2x51Lig4.7241NoYes4010
E2E2x529.3381YesNo3511
E2x52Lig7.474671NoYes5010
5x36E214.79171NoYes5321
5x39E23.221671YesYes7321
6x446x484.459831YesYes9821
6x476x483.33751NoYes8821
6x477x458.498331NoYes8922
6x486x523.433171YesYes8712
6x487x416.825331YesNo8712
6x487x457.003331YesYes8912
6x51Lig8.0061YesYes7010
6x61E36.20NoYes4321
6x62E33.785831NoYes1311
E3Lig4.55751YesYes3010
E3E34.781831YesYes3311
7x347x387.7331YesYes4511
7x34Lig3.23651YesYes4010
7x387x423.395831YesYes5711
7x38Lig5.396671YesYes5010
7x42Lig3.156331YesYes7010
1x397x423.553171YesYes7721
2x533x364.933330YesNo7721
2x607x383.665171NoYes7521
2x64Lig3.845171NoYes5010
3x29E2x504.59851YesYes5912
6x516x526.45451YesYes7712
6x517x383.5841YesYes7511
3x406x489.43550NoYes8821
7x397x424.804331NoYes7721
2x533x325.345330YesYes7821
6x447x453.883671YesYes9922
6x48Lig3.700671YesYes8010
7x27E33.124670NoYes0321
7x317x357.305331NoNo3512
7x31Lig8.720671NoYes3010
E2NT6.8641YesYes3012
2x603x293.774671NoYes7521
2x632x645.734671YesNo5511
E1Lig3.3671NoYes0010
6x586x624.126330NoNo4121
6x62Lig4.261671NoYes1010
E1E1x494.179671NoNo0412
E2E34.905331YesYes3311
6x587x343.3010NoYes4421
2x63E2x503.808331YesYes5912
6x557x343.1950NoYes7421
E3NT5.623331YesYes3012
1x327x314.470NoNo5321
2x66E15.596670NoNo5021
6x456x482.750NoYes6821
6x547x342.680670NoYes5421
5x33E22.376670NoYes3321
6x57E32.339170NoYes5321
6x517x372.305331YesNo7612
5x35E22.245331NoYes4321
6x60E31.752671NoYes5321
4x68E21.6651NoYes0321

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
66.67Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
64.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
59.09Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
59.09Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
58.33Single6JODAngiotensin II6JOD-AT2-Angiotensin II
58.33Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
58.33Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
58.33Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
57.69Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
57.69Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
57.69Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
57.14Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
57.14Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
56.52Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
56.00Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
56.00Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
56.00Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
55.56Single6IGLIRL16206IGL-ETB-IRL1620
55.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
55.00Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
54.55Single4UG2CGS216804UG2-A2A-CGS21680
54.55Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
54.55Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
54.17Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
53.85Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
53.57Single6IGKEndothelin-36IGK-ETB-Endothelin-3
53.57Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
53.57Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
53.57Consensusbombesin_onOrthosteric Ligandbb2_on
53.57Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
53.57Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
52.63Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
52.63Single8K5DGSK2560738K5D-HCA2-GSK256073
52.63Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
52.63Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
52.63Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
52.63Consensushca_on_gpOrthosteric Ligandhca2_on_gp
52.38Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
52.38Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
52.17Single8WDTphotoNECA8WDT-A2A-photoNECA
52.17Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
52.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
50.00Single3QAKUK-4320973QAK-A2A-UK-432097
50.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
50.00Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
50.00Single7EZCUKA7EZC-A2A-UKA
50.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
50.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
50.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
50.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
50.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
50.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
50.00Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
50.00Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
50.00Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
50.00Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
50.00Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
50.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
50.00Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
50.00Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
50.00Consensusprostanoid_offOrthosteric Ligandep_off dp_off
50.00Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
50.00Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
48.28Single5GLHEndothelin-15GLH-ETB-Endothelin-1
48.15Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
48.00Single5WF5UK-4320975WF5-A2A-UK-432097
48.00Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
48.00Consensusangiotensin_onOrthosteric Ligandat1_on
48.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
48.00Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
48.00Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
48.00Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
48.00Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
47.83Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
47.83Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
47.83Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
47.83Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
47.83Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
47.62Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
47.62Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
47.37Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
47.37Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
47.37Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
47.37Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
47.37Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
47.37Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
47.37Consensushca_onOrthosteric Ligandhca2_on
47.37Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
46.43Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
46.15Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
46.15Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
46.15Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
46.15Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
46.15Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
46.15Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
46.15Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
45.83Single7F8XNN90567F8X-CCKA-NN9056
45.83Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
45.83Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
45.83Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
45.83Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
45.83Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
45.83Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
45.83Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
45.83Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
45.83Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
45.83Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
45.45Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
45.45Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
45.45Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
45.45Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
45.45Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
45.45Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
45.45Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
45.45Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
45.45Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.45Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
45.45Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
45.45Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
45.45Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
45.45Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
45.16Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
45.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
45.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
45.00Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
45.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
45.00Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
45.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
45.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
45.00Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
45.00Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
45.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
45.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
44.44Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
44.44Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
44.44Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
44.44Single8ZRTET-18ZRT-ETB-ET-1
44.44Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
44.44Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
44.44Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
44.44Consensusgq_nucleotideOrthosteric Ligandgq_p2y
44.44Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
44.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
44.00Single7XNACYN1548067XNA-SST2-CYN154806
44.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
44.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
44.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
43.48Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
43.48Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
43.48Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
43.48Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
43.48Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
43.48Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
43.48Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
43.48Consensuscck_onOrthosteric Ligandccka_on cckb_on
43.48Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
43.48Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
43.48Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
43.48Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
43.33Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
42.86Single4XT3Fractalkine4XT3-US28-Fractalkine
42.86Single5N2SPSB365N2S-A1-PSB36
42.86Single6D26Fevipiprant6D26-DP2-Fevipiprant
42.86Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
42.86Single7C61Ergotamine7C61-5-HT1B-Ergotamine
42.86Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
42.86Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
42.86Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
42.86Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
42.86Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
42.86Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
42.86Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
42.86Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
42.86Consensusdp_offOrthosteric Liganddp2_off
42.86Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
42.86Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
42.86Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
42.86Consensustrace-amine_onOrthosteric Ligandta1_on
42.31Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
42.31Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
42.31Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
42.31Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
42.31Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
42.31Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
42.11Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
42.11Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.11Single8GNGIstradefylline8GNG-A2A-Istradefylline
42.11Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
42.11Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
42.11Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
41.94Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
41.94Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
41.94Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
41.67Single3NY9ICI118-5513NY9-β2-ICI118-551
41.67Single5WF6UK-4320975WF6-A2A-UK-432097
41.67Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
41.67Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
41.67Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
41.67Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
41.67Single7XN9L-054,5227XN9-SST2-L-054,522
41.67Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
41.67Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
41.67Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
41.67Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
41.38Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
41.38Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
41.38Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
41.38Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
41.38Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
41.38Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
40.91Single2YDVNECA2YDV-A2A-NECA
40.91Single4UHRCGS216804UHR-A2A-CGS21680
40.91Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
40.91Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
40.91Single5G53NECA5G53-A2A-NECA-Gs
40.91Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
40.91Single7B6WCyclazosin7B6W-α1b-Cyclazosin
40.91Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
40.91Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
40.91Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
40.91Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
40.91Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.91Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.91Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
40.91Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
40.91Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
40.91Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
40.91Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
40.91Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
40.91Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.91Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
40.91Consensusa2_onOrthosteric Liganda2b_on
40.91Consensusa2_on_gpOrthosteric Liganda2b_on_gp
40.91Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
40.91Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
40.91Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
40.91Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
40.91Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
40.91Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
40.91Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
40.91Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
40.91Consensusrelaxin_onOrthosteric Ligandrxfp4_on
40.91Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
40.91Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.91Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
40.74Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
40.74Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
40.74Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
40.74Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
40.74Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
40.74Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
40.74Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
40.00Single2YDOAdenosine2YDO-A2A-Adenosine
40.00Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
40.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
40.00Single4XT1Fractalkine4XT1-US28-Fractalkine
40.00Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
40.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
40.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
40.00Single6MH8ZM-2413856MH8-A2A-ZM-241385
40.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
40.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
40.00Single7T32ZM-2413857T32-A2A-ZM-241385
40.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
40.00Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
40.00Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
40.00Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
40.00Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
40.00Single8IHKAcifran8IHK-HCA3-Acifran
40.00Single8IY6Endothelin-18IY6-ETB-Endothelin-1
40.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
40.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
40.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
40.00Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
40.00Single8K5CAcipimox8K5C-HCA2-Acipimox
40.00Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
40.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
40.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
40.00Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
40.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
40.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
40.00Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
40.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
40.00Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
40.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
40.00Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
40.00Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
40.00Consensusbradykinin_onOrthosteric Ligandbk2_on
40.00Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
40.00Consensusendothelin_onOrthosteric Ligandetb_on eta_on
40.00Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
40.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
40.00Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
40.00Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
40.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
40.00Consensussomatostatin_offOrthosteric Ligandsst2_off
39.29Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
39.29Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
39.29Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
39.29Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
39.29Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
39.29Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
39.29Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
39.29Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
39.29Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
39.13Single4AMIBucindolol4AMI-β1-Bucindolol
39.13Single4RWADIPP-NH24RWA-δ-DIPP-NH2
39.13Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
39.13Single6A93Risperidone6A93-5-HT2A-Risperidone
39.13Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
39.13Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
39.13Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
39.13Single6ZG4HTL00099366ZG4-M1-HTL0009936
39.13Single7DFPSpiperone7DFP-D2-Spiperone
39.13Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
39.13Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
39.13Single7K15MKD0467K15-BLT1-MKD046-Na
39.13Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
39.13Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
39.13Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
39.13Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
39.13Single7YITNalfurafine7YIT-κ-Nalfurafine
39.13Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
39.13Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
39.13Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
39.13Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
39.13Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
39.13Single8JJLOlodaterol8JJL-β2-Olodaterol
39.13Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
39.13Single8JWY2-1188JWY-A2A-2-118
39.13Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
39.13Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
39.13Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
39.13Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
39.13Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
39.13Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
39.13Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
39.13Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
39.13Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
39.13Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
39.13Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
39.13Consensuslpa_offOrthosteric Ligandlpa1_off
39.13Consensuslpl_offOrthosteric Ligands1p_off lpa_off
39.13Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
39.13Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
39.13Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
39.13Consensusorexin_onOrthosteric Ligandox2_on
39.13Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
39.13Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
38.89Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
38.71Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
38.46Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
38.46Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
38.46Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
38.46Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
38.46Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
38.46Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
38.46Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
38.46Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
38.46Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
38.10Single2Y04Salbutamol2Y04-β1-Salbutamol
38.10Single3EMLZM-2413853EML-A2A-ZM-241385
38.10Single3NY8ICI118-5513NY8-β2-ICI118-551
38.10Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
38.10Single4GBRS-Carazolol4GBR-β2-S-Carazolol
38.10Single4QKX35V4QKX-β2-35V
38.10Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
38.10Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
38.10Single6D27CAY104716D27-DP2-CAY10471
38.10Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
38.10Single6PS1Timolol6PS1-β2-Timolol
38.10Single6S0LZM-2413856S0L-A2A-ZM-241385
38.10Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
38.10Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
38.10Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
38.10Single8CU6LJ-45178CU6-A2A-LJ-4517
38.10Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
38.10Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
38.10Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
38.10Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
38.10Single8JJOAlprenolol8JJO-β2-Alprenolol
38.10Single8JXRLSD8JXR-D1-LSD
38.10Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
38.10Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
38.10Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
38.10Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.10Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.10Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.10Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
38.10Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
38.10Single9CHXS-Carazolol9CHX-β2-S-Carazolol
38.10Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
38.10Consensusa3_onOrthosteric Liganda3a_on
38.10Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
38.10Consensusdopamine_offOrthosteric Ligandd2_off d3_off
38.10Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
38.10Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
38.10Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
38.10Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
38.10Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
38.10Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
37.93Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
37.50Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
37.50Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
37.50Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
37.50Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
37.50Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
37.50Single6IBLArformoterol6IBL-β1-Arformoterol
37.50Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
37.50Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
37.50Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
37.50Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
37.50Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
37.50Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
37.50Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
37.50Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
37.50Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
37.50Consensuschemerin_onOrthosteric Ligandcml1_on
37.50Consensusendothelin_offOrthosteric Ligandetb_off
37.50Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
37.50Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
37.50Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
37.50Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
37.04Single3OE0CVX153OE0-CXCR4-CVX15
37.04Single6PT2KGCHM076PT2-δ-KGCHM07
37.04Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
37.04Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
37.04Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
37.04Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
37.04Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
37.04Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
37.04Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
36.84Single3OE9IT1t3OE9-CXCR4-IT1t
36.84Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
36.84Single8K5BNiacin8K5B-HCA2-Niacin
36.84Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
36.84Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
36.84Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
36.84Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
36.84Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
36.67Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.67Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
36.67Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
36.67Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
36.36Single2RH1S-Carazolol2RH1-β2-S-Carazolol
36.36Single2Y03Isoprenaline2Y03-β1-Isoprenaline
36.36Single2YCWS-Carazolol2YCW-β1-S-Carazolol
36.36Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
36.36Single5D6LS-Carazolol5D6L-β2-S-Carazolol
36.36Single5IUAQ274563485IUA-A2A-Q27456348-Na
36.36Single5N2RPSB-365N2R-A2A-PSB-36-Na
36.36Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
36.36Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
36.36Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
36.36Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
36.36Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
36.36Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
36.36Single6LUQHaloperidol6LUQ-D2-Haloperidol
36.36Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
36.36Single6PS6Timolol6PS6-β2-Timolol
36.36Single6S0QZM-2413856S0Q-A2A-ZM-241385
36.36Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
36.36Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
36.36Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
36.36Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
36.36Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
36.36Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.36Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
36.36Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
36.36Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
36.36Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
36.36Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
36.36Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
36.36Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
36.36Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
36.36Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8GNEKW-63568GNE-A2A-KW-6356-Na
36.36Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
36.36Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
36.36Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
36.36Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
36.36Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
36.36Consensusa3_on_gpOrthosteric Liganda3a_on_gp
36.36Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
36.36Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
36.36Consensusadenosine_offOrthosteric Liganda1_off a2_off
36.36Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
36.36Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
36.36Consensusamine_offonOrthosteric Ligandamine_off amine_on
36.36Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
36.36Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
36.36Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
36.36Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
36.36Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
36.36Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
36.36Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
36.36Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
36.36Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
36.36Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
36.36Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
36.36Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
36.36Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
36.36Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
36.00Single5ZTYAM102575ZTY-CB2-AM10257
36.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
36.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
36.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
36.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
36.00Single7SK9CCX6627SK9-ACKR3-CCX662
36.00Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
36.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
36.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single8QJ2pN1628QJ2-MC4-pN162-Gs
36.00Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
36.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
36.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
36.00Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
36.00Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
35.71Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
35.71Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
35.71Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
35.71Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
35.71Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
35.71Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
35.71Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
35.71Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
35.71Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
35.48Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
35.48Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
35.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
35.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
35.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
35.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
35.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
35.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
35.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
35.00Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
35.00Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
35.00Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
35.00Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
35.00Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
35.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
35.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
35.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
35.00Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
35.00Single8IWESpermidine8IWE-TA9-Spermidine
35.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
35.00Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
35.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
35.00Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
35.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
35.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
35.00Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
35.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
35.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
35.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
35.00Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
35.00Single8Y0HVUF114188Y0H-CXCR3-VUF11418
35.00Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
35.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
35.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
35.00Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
35.00Consensusalpha2_offOrthosteric Ligandalpha2c_off
35.00Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
35.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
35.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
35.00Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
35.00Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
34.78Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
34.78Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
34.78Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
34.78Single5D5AS-Carazolol5D5A-β2-S-Carazolol
34.78Single5D5BS-Carazolol5D5B-β2-S-Carazolol
34.78Single5XR8AM8415XR8-CB1-AM841
34.78Single6H7JIsoprenaline6H7J-β1-Isoprenaline
34.78Single6J21Aprepitant6J21-NK1-Aprepitant
34.78Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
34.78Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
34.78Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
34.78Single6TQ7SB-3348676TQ7-OX1-SB-334867
34.78Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
34.78Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
34.78Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
34.78Single7PX4PSB-21137PX4-A2A-PSB-2113
34.78Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
34.78Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
34.78Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
34.78Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
34.78Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
34.78Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
34.78Single8E0GBU728E0G-μ-BU72
34.78Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
34.78Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
34.78Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
34.78Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
34.78Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
34.78Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
34.78Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
34.78Single8XVLZibotentan8XVL-ETA-Zibotentan
34.78Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
34.78Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
34.78Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
34.78Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
34.78Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
34.78Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
34.78Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
34.78Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
34.78Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
34.78Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
34.78Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
34.78Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
34.62Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
34.62Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
34.62Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
34.62Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
34.62Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
34.62Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
34.62Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
34.62Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
34.62Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
34.62Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
34.62Consensuslpl_onOrthosteric Ligands1p_on lpa_on
34.62Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
34.62Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
34.62Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
34.48Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
34.48Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
34.48Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
34.48Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
34.48Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
34.48Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
34.48Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
34.48Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
34.38Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
34.38Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
34.38Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
34.38Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
33.33Single3D4STimolol3D4S-β2-Timolol
33.33Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
33.33Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
33.33Single4LDEBI1671074LDE-β2-BI167107
33.33Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
33.33Single4XEENeurotensin4XEE-NTS1-Neurotensin
33.33Single4XESNeurotensin4XES-NTS1-Neurotensin
33.33Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
33.33Single5IU7Q274563465IU7-A2A-Q27456346-Na
33.33Single5JTBZM-2413855JTB-A2A-ZM-241385
33.33Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
33.33Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
33.33Single5UVIZM-2413855UVI-A2A-ZM-241385
33.33Single6CM4Risperidone6CM4-D2-Risperidone
33.33Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
33.33Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
33.33Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
33.33Single6KUXRS-799486KUX-α2a-RS-79948
33.33Single6MXTSalmeterol6MXT-β2-Salmeterol
33.33Single6OS2TRV0266OS2-AT1-TRV026
33.33Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
33.33Single6PS0S-Carazolol6PS0-β2-S-Carazolol
33.33Single6PS4ICI118-5516PS4-β2-ICI118-551
33.33Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
33.33Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
33.33Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
33.33Single6YVRNTS8-136YVR-NTS1-NTS8-13
33.33Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
33.33Single6ZG9GSK10347026ZG9-M1-GSK1034702
33.33Single7AROLUF58337ARO-A2A-LUF5833-Na
33.33Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
33.33Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
33.33Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
33.33Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
33.33Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
33.33Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
33.33Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
33.33Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
33.33Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
33.33Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
33.33Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
33.33Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
33.33Single7UL3Famotidine7UL3-H2-Famotidine
33.33Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
33.33Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
33.33Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
33.33Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
33.33Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
33.33Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
33.33Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
33.33Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
33.33Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
33.33Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
33.33Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
33.33Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
33.33Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
33.33Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8JJ8Formoterol8JJ8-β2-Formoterol
33.33Single8JWZAB9288JWZ-A2A-AB928-Na
33.33Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
33.33Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
33.33Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
33.33Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
33.33Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
33.33Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
33.33Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
33.33Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
33.33Single8XYIVUF106618XYI-CXCR3-VUF10661
33.33Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
33.33Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
33.33Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
33.33Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
33.33Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
33.33Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
33.33Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
33.33Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
33.33Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
33.33Consensusa2_offOrthosteric Liganda2a_off
33.33Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
33.33Consensusalpha1_offOrthosteric Ligandalpha1a_off
33.33Consensusalpha1_onOrthosteric Ligandalpha1a_on
33.33Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
33.33Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
33.33Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
33.33Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
33.33Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
33.33Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
33.33Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
33.33Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
33.33Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
33.33Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
33.33Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
33.33Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
33.33Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
33.33Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
33.33Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
33.33Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
33.33Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
33.33Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
33.33Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
33.33Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.26Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
32.14Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
32.14Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
32.14Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
32.14Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
32.14Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
32.14Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
32.14Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
32.14Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
32.14Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
32.14Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
32.14Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
32.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
32.00Single5X93K-87945X93-ETB-K-8794
32.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
32.00Single6H7LDobutamine6H7L-β1-Dobutamine
32.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
32.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
32.00Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
32.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
32.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
32.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
32.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
32.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
32.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
32.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
32.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
32.00Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
32.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
32.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
32.00Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
32.00Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
32.00Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
32.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
32.00Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
31.82Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
31.82Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
31.82Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
31.82Single4EJ4Naltrindole4EJ4-δ-Naltrindole
31.82Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
31.82Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
31.82Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
31.82Single4YAYZD-71554YAY-AT1-ZD-7155
31.82Single5IU8Q274563475IU8-A2A-Q27456347-Na
31.82Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
31.82Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
31.82Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
31.82Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
31.82Single5TGZAM65385TGZ-CB1-AM6538
31.82Single5UIGCmpd-15UIG-A2A-Cmpd-1
31.82Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
31.82Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
31.82Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
31.82Single6DRXLisuride6DRX-5-HT2B-Lisuride
31.82Single6H7MSalbutamol6H7M-β1-Salbutamol
31.82Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
31.82Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
31.82Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
31.82Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
31.82Single6TOTLemborexant6TOT-OX1-Lemborexant
31.82Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
31.82Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
31.82Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
31.82Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
31.82Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
31.82Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
31.82Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
31.82Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
31.82Single7PYRPSB-21157PYR-A2A-PSB-2115
31.82Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
31.82Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
31.82Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
31.82Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
31.82Single7UL4Alvimopan7UL4-μ-Alvimopan
31.82Single7V3ZCP559407V3Z-CB1-CP55940
31.82Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
31.82Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
31.82Single7WC7Lisuride7WC7-5-HT2A-Lisuride
31.82Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
31.82Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
31.82Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
31.82Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
31.82Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
31.82Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
31.82Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
31.82Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
31.82Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
31.82Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
31.82Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
31.82Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
31.82Single8RLNLUF58348RLN-A2A-LUF5834
31.82Single8T1WCVN4248T1W-GPR6-CVN424
31.82Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
31.82Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
31.82Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
31.82Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
31.82Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
31.82Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
31.82Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
31.82Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
31.82Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
31.82Consensusalpha2_onOrthosteric Ligandalpha2b_on
31.82Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
31.82Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
31.82Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
31.82Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
31.82Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
31.82Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
31.82Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
31.82Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
31.82Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
31.82Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
31.82Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
31.82Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
31.82Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
31.58Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
31.58Single3OE6IT1t3OE6-CXCR4-IT1t
31.58Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
31.58Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
31.58Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
31.58Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
31.58Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
31.58Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
31.58Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
31.58Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
31.58Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
31.25Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
31.25Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
31.03Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
31.03Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
31.03Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
31.03Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
30.77Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
30.77Single6PT3DPI-2876PT3-δ-DPI-287
30.77Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
30.77Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
30.77Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
30.77Single8X5YAstemizole8X5Y-H1-Astemizole
30.77Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
30.77Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
30.77Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
30.77Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
30.77Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
30.77Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
30.43Single2Y00Dobutamine2Y00-β1-Dobutamine
30.43Single5C1MBU725C1M-μ-BU72
30.43Single5JQHS-Carazolol5JQH-β2-S-Carazolol
30.43Single5WIUNemonapride5WIU-D4-Nemonapride
30.43Single5WIVNemonapride5WIV-D4-Nemonapride-Na
30.43Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
30.43Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
30.43Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
30.43Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
30.43Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
30.43Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
30.43Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
30.43Single7C4SS1P7C4S-S1P3-S1P
30.43Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
30.43Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
30.43Single7SINNPS-21437SIN-CaS-NPS-2143
30.43Single7SINNPS-21437SIN-CaS-NPS-2143
30.43Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
30.43Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
30.43Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
30.43Single7W41PD1762527W41-BB2-PD176252
30.43Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
30.43Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
30.43Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.43Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
30.43Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.43Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
30.43Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
30.43Single8JXSPF-61428JXS-D1-PF-6142
30.43Single8QOTNanobody-E8QOT-μ-Nanobody-E
30.43Single8S4DCMF-0198S4D-Apelin-CMF-019
30.43Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
30.43Single8ZMFA1L108ZMF-5-HT2C-A1L10
30.43Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
30.43Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
30.43Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
30.43Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
30.43Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
30.43Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
30.43Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
30.43Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
30.43Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
30.43Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
30.43Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
30.43Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
30.43Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
30.43Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
30.43Consensusblt_offOrthosteric Ligandblt1_off
30.43Consensusbombesin_offOrthosteric Ligandbb2_off
30.43Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.43Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
30.43Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
30.43Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
30.43Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
30.43Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
30.43Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
30.43Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
30.43Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.43Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.43Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
30.30Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
30.30Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
30.00Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
30.00Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
30.00Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
30.00Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
30.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
30.00Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
30.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
30.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
30.00Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
30.00Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
30.00Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
30.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
30.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
30.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
30.00Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
30.00Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
30.00Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
30.00Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
30.00Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
30.00Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
30.00Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
30.00Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
30.00Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
30.00Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
30.00Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
29.73Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
29.73Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
29.63Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
29.63Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
29.63Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
29.63Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
29.63Single8XWNCXCL88XWN-CXCR2-CXCL8
29.63Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
29.63Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
29.63Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
29.63Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
29.63Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
29.63Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
29.41Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
29.17Single3P0GBI1671073P0G-β2-BI167107
29.17Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
29.17Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
29.17Single4DJHJDTic4DJH-κ-JDTic
29.17Single4U15Tiotropium4U15-M3-Tiotropium
29.17Single5V54Methiothepin5V54-5-HT1B-Methiothepin
29.17Single5XRAAM115425XRA-CB1-AM11542
29.17Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
29.17Single6J20Aprepitant6J20-NK1-Aprepitant
29.17Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
29.17Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
29.17Single6OL9Tiotropium6OL9-M5-Tiotropium
29.17Single6OS1TRV0266OS1-AT1-TRV026
29.17Single6WGTLSD6WGT-5-HT2A-LSD
29.17Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
29.17Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
29.17Single7FEECP559407FEE-CB1-CP55940-ZCZ011
29.17Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
29.17Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
29.17Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
29.17Single7TUYGSK682753A7TUY-GPR183-GSK682753A
29.17Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
29.17Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
29.17Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
29.17Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
29.17Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
29.17Single8EA0Iperoxo8EA0-M3-Iperoxo
29.17Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
29.17Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
29.17Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
29.17Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
29.17Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
29.17Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
29.17Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.17Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
29.17Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
29.17Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
29.17Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
29.17Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
29.17Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
29.17Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
29.17Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
29.17Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
29.17Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
29.17Consensus5ht1_offOrthosteric Ligand5ht1b_off
29.17Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
29.17Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.17Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
29.17Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
29.17Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
29.17Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
29.17Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
29.17Consensusneurotensin_onOrthosteric Ligandnts1_on
29.17Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
29.17Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
29.17Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
29.03Single6FJ3PTH6FJ3-PTH1-PTH
29.03Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
29.03Single7SK3CXCL127SK3-ACKR3-CXCL12
29.03Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
29.03Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
29.03Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
28.57Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
28.57Single3ODUIT1t3ODU-CXCR4-IT1t
28.57Single3PWHZM-2413853PWH-A2A-ZM-241385
28.57Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
28.57Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
28.57Single4BWBNeurotensin4BWB-NTS1-Neurotensin
28.57Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
28.57Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
28.57Single6B73MP11046B73-κ-MP1104
28.57Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
28.57Single6HLOAprepitant6HLO-NK1-Aprepitant
28.57Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
28.57Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
28.57Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
28.57Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
28.57Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
28.57Single6TODEMPA6TOD-OX1-EMPA-Na
28.57Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
28.57Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
28.57Single7SK5CXCL127SK5-ACKR3-CXCL12
28.57Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
28.57Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
28.57Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
28.57Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
28.57Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
28.57Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
28.57Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
28.57Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
28.57Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
28.57Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
28.57Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
28.57Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
28.57Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
28.57Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
28.57Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
28.57Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
28.57Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
28.57Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
28.57Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
28.57Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
28.57Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
28.57Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
28.12Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
28.12Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
28.12Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
28.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
28.00Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
28.00Single5CXVTiotropium5CXV-M1-Tiotropium
28.00Single6KQICP559406KQI-CB1-CP55940-Org27569
28.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
28.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
28.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
28.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
28.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
28.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.00Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.00Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
28.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
28.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
28.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
28.00Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
28.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
28.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
28.00Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
28.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
28.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
28.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
28.00Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
27.78Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
27.78Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
27.59Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
27.59Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
27.59Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
27.59Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
27.27Single3REYXAC3REY-A2A-XAC
27.27Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
27.27Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
27.27Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
27.27Single4ZJCSB-6740424ZJC-OX1-SB-674042
27.27Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
27.27Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
27.27Single5IUBQ274563445IUB-A2A-Q27456344-Na
27.27Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
27.27Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
27.27Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
27.27Single6A94Zotepine6A94-5-HT2A-Zotepine
27.27Single6AQFZM-2413856AQF-A2A-ZM-241385
27.27Single6IQLL7458706IQL-D4-L745870
27.27Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
27.27Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
27.27Single6PS5S-Propranolol6PS5-β2-S-Propranolol
27.27Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
27.27Single6TPGEMPA6TPG-OX2-EMPA
27.27Single6TPNHTL66416TPN-OX2-HTL6641
27.27Single6V9SGTPL114036V9S-OX1-GTPL11403
27.27Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
27.27Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
27.27Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
27.27Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
27.27Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
27.27Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
27.27Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
27.27Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
27.27Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
27.27Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
27.27Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
27.27Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
27.27Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
27.27Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
27.27Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
27.27Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
27.27Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
27.27Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
27.27Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
27.27Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
27.27Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
27.27Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
27.27Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
27.27Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
27.27Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
27.27Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
27.27Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
27.27Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
27.27Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single9BJKNaloxone9BJK-μ-Naloxone-NAM
27.27Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
27.27Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
27.27Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
27.27Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
27.27Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
27.27Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
27.27Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
27.27Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
27.27Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
27.27Consensusopsins_offOrthosteric Ligandrhodopsin_off
27.27Consensussensory_offOrthosteric Ligandopsins_off
26.92Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
26.92Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
26.92Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
26.92Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
26.92Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.92Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
26.92Single7UM4AS26747237UM4-5-HT5A-AS2674723
26.92Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
26.92Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.92Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
26.92Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
26.92Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
26.92Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
26.92Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
26.92Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
26.92Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single8XVUCXCL28XVU-CXCR2-CXCL2
26.92Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
26.92Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
26.92Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
26.92Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
26.67Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
26.67Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
26.67Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
26.67Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
26.67Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
26.67Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
26.67Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
26.67Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
26.67Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
26.67Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
26.67Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
26.67Consensusvasop-oxy_onOrthosteric Ligandv2_on
26.67Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
26.47Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
26.32Single8A2OTheophylline8A2O-A2A-Theophylline-Na
26.32Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
26.32Single9CHUNoradrenaline9CHU-β2-Noradrenaline
26.32Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
26.32Consensussensory_onOrthosteric Ligandopsins_on
26.09Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
26.09Single2Y01Dobutamine2Y01-β1-Dobutamine
26.09Single2Y02Carmoterol2Y02-β1-Carmoterol
26.09Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
26.09Single4DAJTiotropium4DAJ-M3-Tiotropium
26.09Single4MQSIperoxo4MQS-M2-Iperoxo
26.09Single4U14Tiotropium4U14-M3-Tiotropium
26.09Single5DHGC-355DHG-NOP-C-35
26.09Single5DHHSB-6121115DHH-NOP-SB-612111
26.09Single5DSGTiotropium5DSG-M4-Tiotropium
26.09Single5UENDU1725UEN-A1-DU172
26.09Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
26.09Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
26.09Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
26.09Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
26.09Single7BU7BI1671077BU7-β1-BI167107
26.09Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
26.09Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
26.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
26.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
26.09Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
26.09Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
26.09Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
26.09Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
26.09Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
26.09Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
26.09Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
26.09Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
26.09Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
26.09Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
26.09Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
26.09Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
26.09Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
26.09Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
26.09Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
26.09Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
26.09Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
26.09Single8X63Mepyramine8X63-H1-Mepyramine
26.09Single8X64Desloratadine8X64-H1-Desloratadine
26.09Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
26.09Consensus5ht5_onOrthosteric Ligand5ht5a_on
26.09Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
26.09Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
26.09Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
26.09Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
26.09Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
26.09Consensusblt_onOrthosteric Ligandblt1_on
26.09Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
26.09Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
26.09Consensushistamine_offOrthosteric Ligandh1_off
26.09Consensusleukotriene_onOrthosteric Ligandblt_on
26.09Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
26.09Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
25.93Single6KNMJN241-96KNM-Apelin-JN241-9
25.93Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
25.93Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
25.93Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
25.93Single8XQJJN2418XQJ-Apelin-JN241
25.93Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
25.93Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
25.93Consensuskisspeptin_onOrthosteric Ligandkiss1_on
25.93Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
25.81Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
25.81Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
25.81Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
25.71Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
25.71Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
25.64Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
25.58Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
25.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
25.00Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
25.00Single4XNWMRS25004XNW-P2Y1-MRS2500
25.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
25.00Single5CGCHTL142425CGC-mGlu5-HTL14242
25.00Single5TVNLSD5TVN-5-HT2B-LSD
25.00Single5WQCEMPA5WQC-OX2-EMPA
25.00Single5XPRBosentan5XPR-ETB-Bosentan
25.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
25.00Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
25.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
25.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
25.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
25.00Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
25.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
25.00Single6TP6Filorexant6TP6-OX1-Filorexant
25.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
25.00Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
25.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
25.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
25.00Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
25.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
25.00Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
25.00Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
25.00Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
25.00Single7QA8Peptide7QA8-STE2-Peptide
25.00Single7QA8Peptide7QA8-STE2-Peptide
25.00Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
25.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
25.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
25.00Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
25.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
25.00Single7WC6LSD7WC6-5-HT2A-LSD
25.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
25.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
25.00Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
25.00Single8IEBA1LYA8IEB-GPR156-A1LYA
25.00Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
25.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
25.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
25.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
25.00Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
25.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
25.00Single8TF5Oleic acid8TF5-GPR6-Oleic acid
25.00Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
25.00Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
25.00Single8WKYPG-9348WKY-MC4-PG-934
25.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
25.00Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
25.00Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
25.00Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
25.00Consensus5ht2_onOrthosteric Ligand5ht2b_on
25.00Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
25.00Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
25.00Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Consensusgi_sensoryOrthosteric Ligandgi_opsins
25.00Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
25.00Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
25.00Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
25.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
25.00Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
25.00Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
24.32Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
24.32Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
24.32Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.24Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
24.24Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
24.24Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
24.24Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
24.24Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
24.14Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
24.14Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
24.14Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
24.14Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
24.14Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
24.14Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
24.14Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
24.14Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
24.14Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
24.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
24.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
24.00Single5TZRMK86665TZR-FFA1-MK8666
24.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
24.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
24.00Single6E59L-7607356E59-NK1-L-760735
24.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
24.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
24.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
24.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
24.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
24.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
24.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
24.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
24.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
24.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
24.00Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
24.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
24.00Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
24.00Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
24.00Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
24.00Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
24.00Consensuslpa_onOrthosteric Ligandlpa1_on
24.00Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
24.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
24.00Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
24.00Consensustachykinin_offOrthosteric Ligandnk1_off
23.81Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
23.81Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
23.81Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
23.81Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
23.81Single3PBLEticlopride3PBL-D3-Eticlopride
23.81Single5L7IVismodegib5L7I-SMO-Vismodegib
23.81Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
23.81Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
23.81Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
23.81Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
23.81Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
23.81Single7SRQLSD7SRQ-5-HT2B-LSD
23.81Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
23.81Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
23.81Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
23.81Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
23.81Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
23.81Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.81Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
23.81Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
23.81Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
23.81Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.81Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
23.81Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
23.81Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
23.81Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
23.81Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
23.81Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
23.68Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
23.53Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
23.53Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
23.53Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
23.53Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
23.53Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
23.53Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
23.53Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
23.53Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
23.53Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
23.53Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
23.33Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
23.33Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
23.33Single6W25SHU91196W25-MC4-SHU9119-Ca
23.33Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
23.08Single4N4WSANT-14N4W-SMO-SANT-1
23.08Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
23.08Single5X33BIIL2605X33-BLT1-BIIL260
23.08Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
23.08Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
23.08Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
23.08Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
23.08Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single8XWACXCL18XWA-CXCR2-CXCL1
23.08Single8XWMCXCL68XWM-CXCR2-CXCL6
23.08Single8XWSCXCL58XWS-CXCR2-CXCL5
23.08Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
22.86Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
22.73Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
22.73Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
22.73Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
22.73Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
22.73Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
22.73Single4S0VSuvorexant4S0V-OX2-Suvorexant
22.73Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
22.73Single5WS3EMPA5WS3-OX2-EMPA
22.73Single5ZKQABT-4915ZKQ-PAF-ABT-491
22.73Single6AKXA4R6AKX-CCR5-A4R
22.73Single6AKYMaraviroc6AKY-CCR5-Maraviroc
22.73Single6DS0Ly2660976DS0-5-HT2B-Ly266097
22.73Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
22.73Single6ME2Ramelteon6ME2-MT1-Ramelteon
22.73Single6ME9Ramelteon6ME9-MT2-Ramelteon
22.73Single6TPJSuvorexant6TPJ-OX2-Suvorexant
22.73Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
22.73Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
22.73Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
22.73Single7F8ULintitript7F8U-CCKA-Lintitript
22.73Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
22.73Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
22.73Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
22.73Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
22.73Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
22.73Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
22.73Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
22.73Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
22.73Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
22.73Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
22.73Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
22.73Single7XRRLemborexant7XRR-OX2-Lemborexant
22.73Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
22.73Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
22.73Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
22.73Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
22.73Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
22.73Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
22.73Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
22.73Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
22.73Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
22.73Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
22.73Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
22.73Consensusangiotensin_offOrthosteric Ligandat1_off
22.73Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
22.73Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
22.73Consensusorexin_offOrthosteric Ligandox2_off ox1_off
22.73Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
22.73Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
22.73Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
22.73Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
22.58Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
22.58Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
22.58Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
22.58Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
22.58Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
22.58Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
22.22Single5CGDHTL142425CGD-mGlu5-HTL14242
22.22Single6K1QIRL25006K1Q-ETB-IRL2500
22.22Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
22.22Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
22.22Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
22.22Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
22.22Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
22.22Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8XVJMacitentan8XVJ-ETA-Macitentan
22.22Single8XWFCXCL38XWF-CXCR2-CXCL3
22.22Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
22.22Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
22.22Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
22.22Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
21.95Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
21.88Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
21.88Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
21.88Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
21.74Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
21.74Single3RZECidoxepin3RZE-H1-Cidoxepin
21.74Single4MBSMaraviroc4MBS-CCR5-Maraviroc
21.74Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
21.74Single6TP3Nemorexant6TP3-OX1-Nemorexant
21.74Single6TPKRetosiban6TPK-OT-Retosiban
21.74Single6VI4JDTic6VI4-κ-JDTic
21.74Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
21.74Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
21.74Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
21.74Single7VODCariprazine7VOD-5-HT2A-Cariprazine
21.74Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
21.74Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
21.74Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
21.74Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
21.74Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
21.74Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
21.74Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
21.74Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
21.74Consensusvasop-oxy_offOrthosteric Ligandot_off
21.62Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
21.62Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
21.62Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
21.62Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.43Single5EE7MK08935EE7-Glucagon-MK0893
21.43Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
21.43Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
21.43Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
21.43Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
21.21Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
21.21Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
21.21Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
21.21Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
21.21Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
21.05Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
21.05Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
21.05Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
21.05Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
21.05Single7WC4Serotonin7WC4-5-HT2A-Serotonin
21.05Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
21.05Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
21.05Single8PWNTheophylline8PWN-A2A-Theophylline
20.83Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
20.83Single5T04Neurotensin5T04-NTS1-Neurotensin
20.83Single6GPSMK08126GPS-CCR2-MK0812
20.83Single6IIVDaltroban6IIV-TP-Daltroban
20.83Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
20.83Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
20.83Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
20.83Single7F83PF-051904577F83-Ghrelin-PF-05190457
20.83Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
20.83Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
20.83Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
20.83Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
20.83Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
20.83Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
20.83Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
20.83Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
20.83Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
20.83Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
20.83Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
20.83Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
20.83Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
20.83Consensuscck_offOrthosteric Ligandccka_off
20.83Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
20.83Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
20.83Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
20.83Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
20.69Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
20.69Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
20.69Single8KIGSHU91198KIG-MC3-SHU9119-Ca
20.69Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
20.69Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
20.59Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
20.59Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
20.59Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
20.59Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
20.59Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
20.59Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
20.59Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.00Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
20.00Single3OE8IT1t3OE8-CXCR4-IT1t
20.00Single3RFMCaffeine3RFM-A2A-Caffeine
20.00Single4JKVTaladegib4JKV-SMO-Taladegib
20.00Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
20.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
20.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
20.00Single6GPXMK08126GPX-CCR2-MK0812
20.00Single6HLPNetupitant6HLP-NK1-Netupitant
20.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
20.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
20.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
20.00Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
20.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
20.00Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
20.00Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
20.00Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
20.00Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
20.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
20.00Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
20.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
20.00Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.00Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
20.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
20.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
20.00Consensusep_offOrthosteric Ligandep4_off
20.00Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
20.00Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
20.00Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
20.00Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
20.00Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
20.00Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
20.00Consensusp2y_offOrthosteric Ligandp2y1_off
20.00Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
19.35Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
19.35Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
19.35Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
19.35Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
19.35Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
19.23Single5V56TC1145V56-SMO-TC114
19.23Single5V57TC1145V57-SMO-TC114
19.23Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
19.23Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
19.23Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
19.23Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
19.23Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
19.23Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
19.23Single9BJKNAM9BJK-μ-Naloxone-NAM
19.23Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
19.23Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
19.23Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
19.23Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
19.05Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
19.05Single3UZAGTPL92363UZA-A2A-GTPL9236
19.05Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
19.05Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
19.05Single7WC5Psilocin7WC5-5-HT2A-Psilocin
19.05Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
19.05Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
19.05Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
19.05Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
19.05Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
18.92Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
18.75Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
18.75Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
18.75Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
18.52Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
18.52Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
18.52Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
18.52Single4PY02MeSATP4PY0-P2Y12-2MeSATP
18.52Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
18.52Single6IIURamatroban6IIU-TP-Ramatroban
18.52Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
18.52Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
18.52Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
18.52Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
18.52Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
18.52Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
18.52Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
18.52Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
18.52Single8XQJJN2418XQJ-Apelin-JN241
18.52Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
18.52Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
18.52Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
18.42Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
18.18Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
18.18Single4O9RCyclopamine4O9R-SMO-Cyclopamine
18.18Single6HLLCP999946HLL-NK1-CP99994
18.18Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
18.18Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
18.18Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
18.18Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
18.18Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
18.18Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
18.18Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
18.18Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
18.18Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
18.18Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
18.18Single9B9Y7DY9B9Y-CB1-7DY
18.18Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
18.18Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
18.18Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
17.95Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
17.95Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
17.86Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
17.86Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
17.86Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
17.86Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
17.86Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
17.65Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
17.39Single4QINSAG1.54QIN-SMO-SAG1.5
17.39Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
17.39Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
17.39Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
17.39Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
17.39Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
17.39Single7F8YDevazepide7F8Y-CCKA-Devazepide
17.39Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
17.39Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
17.39Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.39Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.39Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
17.39Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
17.39Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
17.39Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
17.39Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
17.39Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
17.39Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
17.24Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
17.24Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
17.24Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
17.24Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
17.14Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
17.14Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
16.67Single6FFIMMPEP6FFI-mGlu5-MMPEP
16.67Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
16.67Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
16.67Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
16.67Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
16.67Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8IEIA1LYA8IEI-GPR156-A1LYA
16.67Single8IEPA1LYA8IEP-GPR156-A1LYA
16.67Single8IEPA1LYA8IEP-GPR156-A1LYA
16.67Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.67Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
16.67Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
16.67Single8K2WAMG4878K2W-CXCR3-AMG487
16.67Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
16.67Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
16.67Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
16.67Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
16.67Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
16.67Consensusgrh_offOrthosteric Ligandgnrh1_off
16.22Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
16.13Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
16.13Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
16.13Single8IEBA1LYA8IEB-GPR156-A1LYA
16.13Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.00Single4QIMANTA XV4QIM-SMO-ANTA XV
16.00Single6FFHFenobam6FFH-mGlu5-Fenobam
16.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
16.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
16.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
16.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
16.00Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
16.00Single9IYAONO-97105319IYA-GPR55-ONO-9710531
15.79Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
15.79Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
15.79Single5MZPCaffeine5MZP-A2A-Caffeine-Na
15.79Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
15.38Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
15.38Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
15.38Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
15.38Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
15.38Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
15.38Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
15.38Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
15.38Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
15.15Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
15.15Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
15.00Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
15.00Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
15.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
15.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.81Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
14.81Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
14.81Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
14.81Single7P2L4YI7P2L-mGlu5-4YI
14.81Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
14.81Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
14.81Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
14.81Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
14.81Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
14.81Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
14.81Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
14.81Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
14.81Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
14.81Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
14.29Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
14.29Single6TQ9SB-4081246TQ9-OX1-SB-408124
14.29Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
14.29Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
14.29Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
14.29Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
14.29Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
14.29Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.89Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
13.79Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
13.79Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
13.79Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
13.64Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
13.64Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
13.64Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
13.64Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
13.64Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
13.64Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
13.64Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
13.64Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
13.64Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
13.33Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
13.33Single8IEIA1LYA8IEI-GPR156-A1LYA
13.33Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
13.33Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.33Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
13.04Single6TP4ACT-4622066TP4-OX1-ACT-462206
13.04Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
13.04Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
13.04Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
13.04Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
13.04Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
12.50Single5U09Taranabant5U09-CB1-Taranabant
12.50Single7BR3Elagolix7BR3-GnRH1-Elagolix
12.50Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
12.50Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
12.50Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single9BA0A1AKN9BA0-CB1-A1AKN
12.50Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
12.12Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
12.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
12.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
12.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
12.00Single6ZINSR486926ZIN-NTS1-SR48692
12.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
12.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
12.00Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
12.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
11.76Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
11.54Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
11.54Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
11.54Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
11.54Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
11.54Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
11.54Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
11.54Single9B9ZA1AKO9B9Z-CB1-A1AKO
11.11Single4NTJAZD12834NTJ-P2Y12-AZD1283
11.11Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
11.11Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
11.11Single6Z4SSR486926Z4S-NTS1-SR48692
11.11Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
11.11Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
11.11Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
10.71Single7R0CAVP7R0C-V2-AVP-Arrestin2
10.71Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
10.71Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
10.53Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
10.34Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
10.34Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
10.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
10.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
10.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
10.00Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
9.68Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
9.52Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
9.38Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
9.38Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
9.09Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
9.09Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
8.70Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
8.70Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
8.70Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
8.70Single8JPSCCL78JPS-ACKR1-CCL7
8.33Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
8.33Single6LI0C176LI0-GPR52-C17
8.33Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
8.33Single7UL2SR486927UL2-NTS1-SR48692-Na
8.33Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
8.33Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
8.33Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
8.33Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
8.33Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
8.33Consensusneurotensin_offOrthosteric Ligandnts1_off
8.33Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
8.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
8.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
8.00Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
8.00Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
8.00Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
8.00Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
7.69Single7VV6C48/807VV6-MRGPRX2-C48/80
7.41Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
7.14Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
7.14Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
7.14Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
7.14Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
7.14Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
5.88Single7SHEPI; PE7SHE-GPR158-PI; PE
5.00Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.55Single8HS2Fab0468HS2-GPR20-Fab046
4.55Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.35Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
4.00Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
3.85Single4K5YCP-3763954K5Y-CRF1-CP-376395
3.70Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single8IYXYL-3658IYX-GPR34-YL-365
3.57Single4Z9GCP-3763954Z9G-CRF1-CP-376395
3.57Single8GTIBMK-C2058GTI-CRF1-BMK-C205
3.45Single8GTGBMK-I1528GTG-CRF1-BMK-I152
3.23Single7SHEPI; PE7SHE-GPR158-PI; PE
3.23Single8GTMBMK-C2038GTM-CRF1-BMK-C203
3.12Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.86Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
gq_peptide gq_cck
gq_kisspeptin
gq_bradykinin
gq_bombesin
gq_angiotensin
gq_amine gq_muscarinic
gq_histamine
gq_nucleotide gq_p2y
Net Summary
Imin 3.086
Number of Linked Nodes 1067
Number of Links 1232
Number of Hubs 176
Number of Links mediated by Hubs 687
Number of Communities 21
Number of Nodes involved in Communities 219
Number of Links involved in Communities 325
Path Summary
Number Of Nodes in MetaPath 103
Number Of Links MetaPath 102
Number of Shortest Paths 1411204
Length Of Smallest Path 3
Average Path Length 37.0484
Length of Longest Path 77
Minimum Path Strength 0.422333
Average Path Strength 5.29368
Maximum Path Strength 21.594
Minimum Path Correlation 0.700833
Average Path Correlation 0.96548
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.35135
Average % Of Corr. Nodes 31.1713
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.2283
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download gq_class-a.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.