Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 6.27254134
2A:A:H41 6.063336106
3A:A:L45 3.8475478
4A:A:S51 2.465409
5A:A:K53 3.035479
6A:A:H220 9.0825417
7A:A:M221 4.2475408
8A:A:F222 10.1925417
9A:A:Q227 5.366519
10A:A:E230 4.21419
11A:A:K233 5.00857719
12A:A:W234 5.688519
13A:A:F238 5.91833619
14A:A:F246 3.71754209
15A:A:Q267 4.8825404
16A:A:F273 4.53333689
17A:A:W277 5.97886
18A:A:W281 7.21615
19A:A:L289 4.2525409
20A:A:F290 3.40571779
21A:A:F312 4.35598
22A:A:E314 4.33596
23A:A:F315 9.425496
24A:A:Y318 6.9175406
25A:A:P321 4.0575405
26A:A:E330 5.76403
27A:A:R333 7.8625495
28A:A:V334 4.1875404
29A:A:R336 6.78495
30A:A:K338 7.78754155
31A:A:Y339 5.301437153
32A:A:F340 9.35597
33A:A:R342 5.3145154
34A:A:E344 5.875495
35A:A:F345 5.956508
36A:A:S349 3.294587
37A:A:Y358 6.0675404
38A:A:Y360 7.1275408
39A:A:F363 6.3025155
40A:A:T364 5.6275479
41A:A:D368 8.87479
42A:A:N371 5.838579
43A:A:R373 3.884145
44A:A:R374 5.245474
45A:A:F376 3.254148
46A:A:I383 3.3145108
47A:A:H387 4.6354108
48A:A:Y391 6.855404
49B:B:L7 4.47408
50B:B:L14 6.8525408
51B:B:I37 4.2185112
52B:B:V40 4.22754113
53B:B:M45 3.022534
54B:B:R49 4.455437
55B:B:H54 10.0465139
56B:B:K57 9.496519
57B:B:Y59 6.58418
58B:B:W63 6.05637
59B:B:R68 11.8125435
60B:B:D76 6.295139
61B:B:W82 9.732509
62B:B:S84 3.52435
63B:B:Y85 11.395434
64B:B:N88 4.435407
65B:B:K89 4.9256199
66B:B:H91 4.645405
67B:B:I93 3.97754247
68B:B:W99 7.03857719
69B:B:M101 5.0275419
70B:B:Y105 3.345406
71B:B:N110 6.7954174
72B:B:Y111 6.12254174
73B:B:L117 3.645619
74B:B:Y124 3.916676246
75B:B:E130 3.754183
76B:B:V133 3.93754244
77B:B:H142 6.21286719
78B:B:Y145 5.64857718
79B:B:R150 4.2354236
80B:B:F151 3.815619
81B:B:L152 3.5525403
82B:B:I157 4.0575417
83B:B:T159 5.745419
84B:B:D163 9.425419
85B:B:L168 3.9525466
86B:B:W169 8.59167618
87B:B:I171 3.095416
88B:B:Q176 6.0875414
89B:B:F180 7.976567
90B:B:H183 7.02333669
91B:B:D186 4.96833619
92B:B:F199 5.872569
93B:B:V200 4.8475446
94B:B:C204 5.122517
95B:B:D205 5.685469
96B:B:K209 9.6725466
97B:B:L210 3.24505
98B:B:W211 9.114568
99B:B:D212 5.335169
100B:B:M217 5.8154163
101B:B:Q220 8.0375447
102B:B:F222 6.064548
103B:B:H225 7.30571749
104B:B:D228 9.29419
105B:B:I232 5.3375448
106B:B:F235 5.76875816
107B:B:P236 5.655417
108B:B:N237 7.8525415
109B:B:F241 5.32143746
110B:B:T243 4.446548
111B:B:D247 7.376549
112B:B:T249 6.29546
113B:B:R251 9.842548
114B:B:F253 6.435446
115B:B:D254 3.5409
116B:B:R256 6.095409
117B:B:D258 8.764547
118B:B:Q259 4.4954216
119B:B:M262 5.9475414
120B:B:Y264 5.02667615
121B:B:H266 6.815414
122B:B:I269 3.182514
123B:B:C271 3.83415
124B:B:F278 5.35417
125B:B:R283 7.8645119
126B:B:L284 3.245405
127B:B:L285 3.585416
128B:B:Y289 5.88143717
129B:B:D290 5.622516
130B:B:R304 7.205415
131B:B:L308 6.195437
132B:B:H311 7.56539
133B:B:R314 12.508518
134B:B:W332 9.11143719
135B:B:D333 6.345439
136B:B:F335 3.835404
137B:B:K337 6.755436
138B:B:W339 5.96143739
139B:B:N340 5.155439
140G:G:R13 4.6425406
141G:G:L19 4.56409
142G:G:R27 6.015448
143G:G:Y40 7.755416
144G:G:D48 6.384509
145G:G:P49 2.5925407
146G:G:L51 4.055116
147G:G:N59 4.062539
148G:G:P60 5.925439
149G:G:F61 4.07875838
150L:L:Y2 5.735620
151L:L:F3 5.88667620
152L:L:Q4 5.424520
153R:R:E40 5.4405
154R:R:F48 4.535406
155R:R:L57 3.55405
156R:R:R65 4.3054125
157R:R:H75 4.36129
158R:R:L81 4.06459
159R:R:V88 3.212527
160R:R:Q92 5.598526
161R:R:Q96 5.43407
162R:R:W99 4.264525
163R:R:F105 9.345428
164R:R:K116 11.325426
165R:R:Y117 5.218505
166R:R:Q119 5.2925407
167R:R:M120 5.684525
168R:R:M123 2.9625427
169R:R:Y124 5.77527
170R:R:S127 3.2875428
171R:R:M129 2.838558
172R:R:R137 3.955409
173R:R:H138 6.29408
174R:R:M145 3.78407
175R:R:V160 5.0075457
176R:R:W164 3.12833659
177R:R:L170 5.925404
178R:R:Q174 8.1075425
179R:R:F178 10.686526
180R:R:T190 4.935404
181R:R:D191 9.334524
182R:R:Y205 7.8525427
183R:R:W208 5.0725423
184R:R:I209 5.572525
185R:R:V266 1.7575407
186R:R:Y280 5.618529
187R:R:W284 8.378528
188R:R:F287 6.08857726
189R:R:F288 5.24667627
190R:R:Q291 11.04426
191R:R:M311 5.622525
192R:R:I324 3.84458
193R:R:Y325 4.806559
194R:R:F328 5.192557
195R:R:E335 5.02254126
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:I26 B:B:K89 10.5594.36NoYes099
2A:A:L30 B:B:K89 13.2892.82NoYes059
3A:A:L30 B:B:K78 13.57922.82NoNo058
4B:B:D76 B:B:K78 15.41618.3YesNo098
5A:A:Y37 B:B:D76 25.88522.3YesYes1349
6A:A:R42 A:A:Y37 29.093915.43NoYes094
7A:A:F222 A:A:R42 29.60144.28YesNo079
8A:A:F219 A:A:H41 68.5177.92NoYes086
9A:A:F212 A:A:F219 68.814112.86NoNo098
10A:A:F212 A:A:M221 69.04622.49NoYes098
11A:A:L45 A:A:M221 69.8425.65YesYes088
12A:A:K53 A:A:L45 76.46172.82YesYes798
13A:A:G47 A:A:K53 87.52623.49NoYes099
14A:A:G47 A:A:L46 87.63811.71NoNo098
15A:A:I276 A:A:L46 87.74961.43NoNo088
16A:A:I276 A:A:L272 75.38294.28NoNo2088
17A:A:L272 A:A:R231 99.94543.64NoNo089
18A:A:R231 A:A:W234 1007NoYes099
19A:A:V224 A:A:W234 12.35198.58NoYes199
20A:A:F238 A:A:V224 12.38273.93YesNo199
21A:A:F238 B:B:W99 10.58159.02YesYes199
22A:A:F222 B:B:W99 33.94518.04YesYes179
23A:A:Q227 A:A:W234 11.75455.48YesYes199
24A:A:Q227 B:B:L117 11.50563.99YesYes199
25B:B:L117 B:B:W99 22.77374.56YesYes199
26A:A:W234 B:B:Y145 24.4823.86YesYes198
27B:B:L117 B:B:Y145 12.61412.34YesYes198
28A:A:H41 A:A:I383 65.16042.65YesYes1068
29A:A:I245 A:A:L45 13.19582.85NoYes778
30A:A:K53 A:A:S51 11.59343.06YesYes099
31A:A:F290 A:A:I245 12.68012.51YesNo797
32A:A:I235 A:A:W234 59.44893.52NoYes099
33B:B:G319 B:B:W63 13.94582.81NoYes057
34B:B:G319 B:B:L318 14.24083.42NoNo056
35B:B:L318 B:B:S275 32.33893NoNo068
36B:B:S275 B:B:T274 32.60934.8NoNo088
37B:B:D290 B:B:T274 17.01952.89YesNo168
38A:A:W281 B:B:D290 53.27657.82YesYes156
39A:A:N279 A:A:W281 59.32722.26NoYes085
40A:A:L282 A:A:N279 59.332210.98NoNo098
41B:B:R314 B:B:T274 15.86845.17YesNo188
42A:A:W281 B:B:R314 12.783715.99YesYes158
43B:B:R314 B:B:W332 10.890725.99YesYes189
44A:A:F246 A:A:L272 24.50836.09YesNo2098
45A:A:F246 A:A:V248 12.51992.62YesNo097
46A:A:F246 A:A:L289 24.26263.65YesYes099
47A:A:F345 A:A:V248 12.0313.93YesNo087
48A:A:F345 A:A:L289 12.07117.31YesYes089
49A:A:F345 A:A:L270 10.85738.53YesNo086
50A:A:L270 A:A:Q267 10.34293.99NoYes064
51A:A:I383 R:R:P144 25.67723.39YesNo089
52A:A:H387 A:A:I383 39.25893.98YesYes1088
53A:A:Q384 R:R:P144 25.89253.16NoNo069
54A:A:Q384 R:R:E231 25.52248.92NoNo065
55A:A:H387 A:A:Y391 39.0644.36YesYes084
56R:R:C142 R:R:E231 25.35266.08NoNo065
57R:R:C142 R:R:H138 25.19368.85NoYes068
58A:A:Y391 R:R:D136 38.6758.05YesNo049
59B:B:C271 B:B:D290 52.6043.11YesYes156
60B:B:C271 B:B:Y289 51.37654.03YesYes157
61B:B:W297 B:B:Y289 48.55965.79NoYes187
62B:B:W297 B:B:Y264 48.62585.79NoYes185
63B:B:L252 B:B:Y264 40.30413.52NoYes075
64B:B:L252 B:B:L261 40.10072.77NoNo075
65B:B:D254 B:B:L261 39.90142.71YesNo095
66B:B:A257 B:B:D254 42.79264.63NoYes079
67B:B:A257 B:B:Q259 42.57843.03NoYes076
68B:B:Q259 B:B:R22 41.93354.67YesNo066
69B:B:D258 B:B:R22 34.83929.53YesNo076
70B:B:L318 B:B:T329 18.65962.95NoNo068
71B:B:D258 B:B:Q220 22.44616.97YesYes477
72B:B:L210 B:B:Q220 22.35072.66YesYes057
73B:B:L210 B:B:R219 19.60523.64YesNo055
74B:B:M217 B:B:R219 18.288514.89YesNo1635
75B:B:M217 G:G:M21 17.95492.89YesNo031
76G:G:M21 G:G:Q18 17.69546.8NoNo019
77B:B:C218 G:G:Q18 17.43553.05NoNo059
78B:B:C218 B:B:W211 13.35836.53NoYes658
79B:B:G162 B:B:Y145 16.38244.35NoYes198
80B:B:G162 B:B:S161 16.26393.71NoNo199
81B:B:H142 B:B:S161 14.396213.95YesNo199
82B:B:H142 B:B:W169 10.68653.17YesYes198
83B:B:D258 B:B:F222 11.23024.78YesYes478
84R:R:D136 R:R:F77 38.545711.94NoNo098
85R:R:F77 R:R:M133 38.2932.49NoNo089
86R:R:L81 R:R:M133 34.94122.83YesNo599
87R:R:L81 R:R:N321 27.41478.24YesNo099
88R:R:D85 R:R:N321 25.45854.04NoNo099
89R:R:D85 R:R:S318 25.237810.31NoNo099
90R:R:S318 R:R:V88 22.54943.23NoYes097
91R:R:Q92 R:R:V88 21.82974.3YesYes267
92R:R:Q119 R:R:Q92 11.46762.56YesYes076
93R:R:C224 R:R:H138 21.15255.9NoYes058
94R:R:C224 R:R:T134 20.77933.38NoNo058
95R:R:I221 R:R:T134 20.6026.08NoNo088
96R:R:I130 R:R:I221 20.26782.94NoNo088
97R:R:I130 R:R:Y280 20.10652.42NoYes089
98R:R:W284 R:R:Y280 16.705612.54YesYes289
99R:R:F287 R:R:W284 11.67423.01YesYes268
100R:R:L81 R:R:M129 10.56552.83YesYes598
101B:B:T329 B:B:W339 14.1597.28NoYes089
102A:A:I235 A:A:L282 59.37182.85NoNo099
103B:B:W332 B:B:Y59 15.3154.82YesYes198
104A:A:C237 B:B:M101 10.48914.86NoYes089
105B:B:M101 B:B:Y145 10.32427.18YesYes198
106A:A:C237 B:B:Y59 12.485.38NoYes088
107A:A:F246 A:A:I276 12.47772.51YesNo2098
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:C1 R:R:M311 3.24 0 No Yes 0 5 0 1
L:L:C1 R:R:L312 4.76 0 No No 0 4 0 1
L:L:Y2 R:R:Q92 11.27 2 Yes Yes 0 6 0 1
L:L:Y2 R:R:Q96 6.76 2 Yes Yes 0 7 0 1
L:L:Y2 R:R:M123 2.39 2 Yes Yes 0 7 0 1
L:L:Y2 R:R:F287 4.13 2 Yes Yes 0 6 0 1
L:L:Y2 R:R:L312 5.86 2 Yes No 0 4 0 1
L:L:Y2 R:R:A314 4 2 Yes No 0 7 0 1
L:L:F3 R:R:M120 3.73 2 Yes Yes 0 5 0 1
L:L:F3 R:R:V206 6.55 2 Yes No 0 5 0 1
L:L:F3 R:R:I209 2.51 2 Yes Yes 0 5 0 1
L:L:F3 R:R:F287 4.29 2 Yes Yes 0 6 0 1
L:L:F3 R:R:F288 5.36 2 Yes Yes 0 7 0 1
L:L:F3 R:R:Q291 12.88 2 Yes Yes 0 6 0 1
L:L:Q4 R:R:R202 2.34 2 Yes No 0 4 0 1
L:L:Q4 R:R:Q291 10.24 2 Yes Yes 0 6 0 1
L:L:Q4 R:R:A294 4.55 2 Yes No 0 4 0 1
L:L:Q4 R:R:A295 4.55 2 Yes No 0 5 0 1
L:L:Q4 R:R:M311 5.44 2 Yes Yes 0 5 0 1
L:L:N5 R:R:W193 2.26 0 No No 0 4 0 1
L:L:N5 R:R:C195 6.3 0 No No 0 2 0 1
L:L:C6 R:R:K100 4.85 0 No No 0 5 0 1
L:L:P7 R:R:E303 6.29 0 No No 0 4 0 1
L:L:P7 R:R:M311 6.71 0 No Yes 0 5 0 1
L:L:R8 R:R:T190 11.64 0 No Yes 0 4 0 1
L:L:R8 R:R:W193 7 0 No No 0 4 0 1
R:R:E40 R:R:K100 10.8 0 Yes No 5 5 2 1
R:R:E40 R:R:V308 2.85 0 Yes No 5 4 2 1
R:R:E40 R:R:L312 5.3 0 Yes No 5 4 2 1
R:R:Q92 R:R:V88 4.3 2 Yes Yes 6 7 1 2
R:R:S315 R:R:V88 3.23 2 No Yes 7 7 2 2
R:R:Q119 R:R:Q92 2.56 0 Yes Yes 7 6 2 1
R:R:M123 R:R:Q92 4.08 2 Yes Yes 7 6 1 1
R:R:Q92 R:R:S315 5.78 2 Yes No 6 7 1 2
R:R:Q96 R:R:W99 3.29 0 Yes Yes 7 5 1 2
R:R:K100 R:R:Q96 2.71 0 No Yes 5 7 1 1
R:R:Q119 R:R:Q96 8.96 0 Yes Yes 7 7 2 1
R:R:T190 R:R:W99 3.64 0 Yes Yes 4 5 1 2
R:R:M120 R:R:M123 2.89 2 Yes Yes 5 7 1 1
R:R:M120 R:R:Y124 4.79 2 Yes Yes 5 7 1 2
R:R:M120 R:R:S171 6.13 2 Yes No 5 7 1 2
R:R:M120 R:R:Q174 10.88 2 Yes Yes 5 5 1 2
R:R:F287 R:R:M123 2.49 2 Yes Yes 6 7 1 1
R:R:S171 R:R:Y124 2.54 2 No Yes 7 7 2 2
R:R:I209 R:R:Y124 4.84 2 Yes Yes 5 7 1 2
R:R:V213 R:R:Y124 3.79 0 No Yes 5 7 2 2
R:R:F178 R:R:Q174 9.37 2 Yes Yes 6 5 2 2
R:R:Q174 R:R:Y205 6.76 2 Yes Yes 5 7 2 2
R:R:C195 R:R:F178 6.98 0 No Yes 2 6 1 2
R:R:T190 R:R:V189 3.17 0 Yes No 4 3 1 2
R:R:A194 R:R:W193 6.48 0 No No 5 4 2 1
R:R:W208 R:R:Y205 2.89 2 Yes Yes 3 7 2 2
R:R:I209 R:R:Y205 13.3 2 Yes Yes 5 7 1 2
R:R:A295 R:R:V206 5.09 0 No No 5 5 1 1
R:R:I209 R:R:W208 4.7 2 Yes Yes 5 3 1 2
R:R:F288 R:R:I209 2.51 2 Yes Yes 7 5 1 1
R:R:A210 R:R:F288 4.16 0 No Yes 5 7 2 1
R:R:F288 R:R:V213 3.93 2 Yes No 7 5 1 2
R:R:F287 R:R:W284 3.01 2 Yes Yes 6 8 1 2
R:R:F288 R:R:W284 8.02 2 Yes Yes 7 8 1 2
R:R:F287 R:R:F288 7.5 2 Yes Yes 6 7 1 1
R:R:F287 R:R:Q291 12.88 2 Yes Yes 6 6 1 1
R:R:A314 R:R:F287 8.32 2 No Yes 7 6 1 1
R:R:M311 R:R:V290 4.56 2 Yes No 5 5 1 2
R:R:M311 R:R:Q291 8.16 2 Yes Yes 5 6 1 1
R:R:A300 R:R:E303 4.53 0 No No 1 4 2 1
L:L:G9 R:R:V308 1.84 0 No No 0 4 0 1
R:R:A179 R:R:C195 1.81 0 No No 4 2 2 1
R:R:L292 R:R:V206 1.49 0 No No 5 5 2 1
R:R:R104 R:R:T190 1.29 0 No Yes 4 4 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
53.57Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
52.00Single3QAKUK-4320973QAK-A2A-UK-432097
51.85Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
51.61Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
50.00Single5WF6UK-4320975WF6-A2A-UK-432097
50.00Single7R0CAVP7R0C-V2-AVP-Arrestin2
50.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
50.00Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
48.15Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
48.15Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
48.15Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
48.15Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
48.15Consensusvasop-oxy_onOrthosteric Ligandv2_on
48.15Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
48.00Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
47.83Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
46.43Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
46.43Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
45.83Single7EZCUKA7EZC-A2A-UKA
45.45Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
44.44Single5WF5UK-4320975WF5-A2A-UK-432097
44.44Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
44.44Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
44.44Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
44.00Single4UG2CGS216804UG2-A2A-CGS21680
44.00Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
44.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
43.33Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
43.33Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
43.33Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
42.86Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
42.31Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
42.31Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
42.31Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
42.31Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
42.31Single8WDTphotoNECA8WDT-A2A-photoNECA
42.31Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
42.31Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
42.31Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
42.31Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
41.94Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
41.94Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
41.94Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
41.94Consensusbradykinin_onOrthosteric Ligandbk2_on
41.94Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
41.94Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
41.67Single4RWADIPP-NH24RWA-δ-DIPP-NH2
41.67Single6MXTSalmeterol6MXT-β2-Salmeterol
41.67Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
41.67Single8JWY2-1188JWY-A2A-2-118
41.67Single8JWZAB9288JWZ-A2A-AB928-Na
41.67Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
41.38Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
40.91Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
40.74Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
40.74Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
40.74Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
40.74Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
40.74Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
40.62Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
40.62Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
40.62Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
40.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
40.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
40.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
40.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
40.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
40.00Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
39.29Single6PT2KGCHM076PT2-δ-KGCHM07
39.29Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
39.29Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
39.29Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
39.29Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
39.29Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
39.29Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
39.29Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
39.13Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
39.13Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
39.13Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
39.13Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
39.13Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
39.13Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
38.71Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
38.71Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
38.71Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
38.71Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
38.71Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
38.71Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
38.71Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
38.46Single5ZTYAM102575ZTY-CB2-AM10257
38.46Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Single7SK9CCX6627SK9-ACKR3-CCX662
38.46Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
38.46Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
38.46Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
37.93Single6JODAngiotensin II6JOD-AT2-Angiotensin II
37.93Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.93Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
37.93Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
37.93Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
37.50Single2YDVNECA2YDV-A2A-NECA
37.50Single4UHRCGS216804UHR-A2A-CGS21680
37.50Single5G53NECA5G53-A2A-NECA-Gs
37.50Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
37.50Single6IGLIRL16206IGL-ETB-IRL1620
37.50Single6J21Aprepitant6J21-NK1-Aprepitant
37.50Single7PX4PSB-21137PX4-A2A-PSB-2113
37.50Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
37.50Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
37.50Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
37.50Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
37.50Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
37.50Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
37.50Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
37.50Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
37.50Consensusa2_onOrthosteric Liganda2b_on
37.50Consensusa2_on_gpOrthosteric Liganda2b_on_gp
37.50Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
37.50Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
37.50Consensusendothelin_onOrthosteric Ligandetb_on eta_on
37.50Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
37.50Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
37.04Single4IARErgotamine4IAR-5-HT1B-Ergotamine
37.04Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
37.04Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
37.04Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
37.04Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
37.04Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
37.04Consensuslpl_onOrthosteric Ligands1p_on lpa_on
37.04Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
36.67Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
36.67Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
36.67Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
36.67Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
36.67Single8ZRTET-18ZRT-ETB-ET-1
36.67Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
36.67Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
36.67Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.36Single4MBSMaraviroc4MBS-CCR5-Maraviroc
36.36Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
36.36Single5IUBQ274563445IUB-A2A-Q27456344-Na
36.36Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
36.36Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
36.36Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
36.36Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
36.36Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
36.36Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
36.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
36.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
36.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
36.00Single7YITNalfurafine7YIT-κ-Nalfurafine
36.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
36.00Single8JJLOlodaterol8JJL-β2-Olodaterol
36.00Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
36.00Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
36.00Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
36.00Consensusalpha1_offOrthosteric Ligandalpha1a_off
36.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
36.00Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
36.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
36.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
35.71Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
35.71Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
35.71Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
35.71Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
35.71Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
35.71Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
35.48Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
35.48Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
35.29Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
35.29Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
35.29Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
35.29Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
34.78Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
34.78Single4EJ4Naltrindole4EJ4-δ-Naltrindole
34.78Single5IU8Q274563475IU8-A2A-Q27456347-Na
34.78Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
34.78Single5UIGCmpd-15UIG-A2A-Cmpd-1
34.78Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
34.78Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
34.78Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
34.78Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
34.78Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
34.78Single7PYRPSB-21157PYR-A2A-PSB-2115
34.78Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
34.78Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
34.78Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
34.78Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
34.78Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
34.78Single9CHXS-Carazolol9CHX-β2-S-Carazolol
34.78Consensusa3_onOrthosteric Liganda3a_on
34.78Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
34.78Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
34.62Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
34.62Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
34.62Single6H7LDobutamine6H7L-β1-Dobutamine
34.62Single6IBLArformoterol6IBL-β1-Arformoterol
34.62Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
34.62Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
34.62Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
34.62Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
34.62Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
34.62Single7UM4AS26747237UM4-5-HT5A-AS2674723
34.62Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
34.62Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
34.62Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
34.62Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.62Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
34.62Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
34.62Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
34.62Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
34.62Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.62Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
34.62Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
34.62Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
34.62Consensuscck_onOrthosteric Ligandccka_on cckb_on
34.62Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
34.62Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
34.62Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
34.62Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
34.62Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
34.62Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
34.62Consensusprostanoid_offOrthosteric Ligandep_off dp_off
34.48Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
34.48Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
34.48Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.48Consensusangiotensin_onOrthosteric Ligandat1_on
34.48Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.48Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
34.48Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
34.48Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
34.38Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
34.38Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
34.38Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
33.33Single3NY9ICI118-5513NY9-β2-ICI118-551
33.33Single5C1MBU725C1M-μ-BU72
33.33Single5IUAQ274563485IUA-A2A-Q27456348-Na
33.33Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
33.33Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
33.33Single6E67BI1671076E67-β2-BI167107-Gs (fused)
33.33Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
33.33Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
33.33Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
33.33Single6PT3DPI-2876PT3-δ-DPI-287
33.33Single6S0QZM-2413856S0Q-A2A-ZM-241385
33.33Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
33.33Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
33.33Single7C61Ergotamine7C61-5-HT1B-Ergotamine
33.33Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
33.33Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
33.33Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
33.33Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
33.33Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
33.33Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
33.33Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
33.33Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
33.33Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
33.33Single7WC6LSD7WC6-5-HT2A-LSD
33.33Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
33.33Single7XN9L-054,5227XN9-SST2-L-054,522
33.33Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
33.33Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
33.33Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
33.33Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
33.33Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
33.33Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
33.33Single8GNEKW-63568GNE-A2A-KW-6356-Na
33.33Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8IY6Endothelin-18IY6-ETB-Endothelin-1
33.33Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
33.33Single8QJ2pN1628QJ2-MC4-pN162-Gs
33.33Single8QOTNanobody-E8QOT-μ-Nanobody-E
33.33Single8TF5Oleic acid8TF5-GPR6-Oleic acid
33.33Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
33.33Single8X5YAstemizole8X5Y-H1-Astemizole
33.33Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
33.33Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
33.33Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
33.33Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
33.33Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
33.33Consensusa3_on_gpOrthosteric Liganda3a_on_gp
33.33Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
33.33Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
33.33Consensusadenosine_offOrthosteric Liganda1_off a2_off
33.33Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
33.33Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
33.33Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
33.33Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
33.33Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
33.33Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
33.33Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
33.33Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
33.33Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
33.33Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
33.33Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
33.33Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
33.33Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
33.33Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
33.33Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
32.35Single5GLHEndothelin-15GLH-ETB-Endothelin-1
32.35Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.35Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.35Consensusbombesin_onOrthosteric Ligandbb2_on
32.35Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
32.35Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
32.35Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.26Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
32.26Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.26Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
32.26Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
32.14Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
32.14Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
32.14Single7F8XNN90567F8X-CCKA-NN9056
32.14Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
32.14Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
32.14Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
32.14Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
32.14Single8XWNCXCL88XWN-CXCR2-CXCL8
32.14Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
32.14Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
32.14Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
32.14Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
32.14Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
32.14Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.00Single3P0GBI1671073P0G-β2-BI167107
32.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
32.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
32.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
32.00Single5V56TC1145V56-SMO-TC114
32.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
32.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
32.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
32.00Single6WGTLSD6WGT-5-HT2A-LSD
32.00Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
32.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
32.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
32.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
32.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
32.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
32.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
32.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
32.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
32.00Single8E0GBU728E0G-μ-BU72
32.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
32.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
32.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
32.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
32.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
32.00Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
32.00Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
32.00Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
32.00Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
32.00Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
32.00Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
32.00Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.00Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
32.00Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
32.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
32.00Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
31.82Single3PWHZM-2413853PWH-A2A-ZM-241385
31.82Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
31.82Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
31.82Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
31.82Single6AKXA4R6AKX-CCR5-A4R
31.82Single6AKYMaraviroc6AKY-CCR5-Maraviroc
31.82Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
31.82Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
31.82Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
31.82Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
31.82Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
31.82Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
31.82Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
31.82Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
31.82Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
31.82Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
31.58Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
31.58Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
31.43Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
31.43Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
31.25Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
31.25Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
31.25Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
31.25Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
31.25Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
31.03Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
31.03Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
31.03Single6HLOAprepitant6HLO-NK1-Aprepitant
31.03Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
31.03Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
31.03Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
31.03Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
31.03Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
31.03Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
31.03Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
31.03Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
31.03Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
31.03Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
31.03Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
30.77Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
30.77Single4AMIBucindolol4AMI-β1-Bucindolol
30.77Single4LDEBI1671074LDE-β2-BI167107
30.77Single4N4WSANT-14N4W-SMO-SANT-1
30.77Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
30.77Single6A93Risperidone6A93-5-HT2A-Risperidone
30.77Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
30.77Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
30.77Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
30.77Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
30.77Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
30.77Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
30.77Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
30.77Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
30.77Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
30.77Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
30.77Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
30.77Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
30.77Single8JJ8Formoterol8JJ8-β2-Formoterol
30.77Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
30.77Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
30.77Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
30.77Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
30.77Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
30.77Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
30.77Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
30.77Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
30.77Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
30.77Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
30.77Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
30.77Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
30.77Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
30.77Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
30.77Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
30.77Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
30.77Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
30.77Consensusorexin_onOrthosteric Ligandox2_on
30.77Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
30.77Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
30.56Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
30.43Single3REYXAC3REY-A2A-XAC
30.43Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
30.43Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
30.43Single5IU7Q274563465IU7-A2A-Q27456346-Na
30.43Single5JTBZM-2413855JTB-A2A-ZM-241385
30.43Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
30.43Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
30.43Single6AQFZM-2413856AQF-A2A-ZM-241385
30.43Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
30.43Single6PS0S-Carazolol6PS0-β2-S-Carazolol
30.43Single6PS4ICI118-5516PS4-β2-ICI118-551
30.43Single6PS5S-Propranolol6PS5-β2-S-Propranolol
30.43Single6TPGEMPA6TPG-OX2-EMPA
30.43Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
30.43Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
30.43Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
30.43Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
30.43Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
30.43Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
30.43Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.43Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.43Single7T32ZM-2413857T32-A2A-ZM-241385
30.43Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
30.43Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
30.43Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
30.43Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
30.43Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
30.43Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
30.43Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
30.43Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
30.43Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
30.43Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
30.43Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.43Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
30.43Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
30.43Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
30.43Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
30.43Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
30.43Consensusa2_offOrthosteric Liganda2a_off
30.43Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
30.43Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
30.43Consensusalpha1_onOrthosteric Ligandalpha1a_on
30.43Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
30.43Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
30.43Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
30.43Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
30.43Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
30.43Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
30.30Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
30.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
30.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
30.00Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
30.00Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
30.00Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
30.00Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
30.00Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
30.00Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
30.00Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
30.00Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
29.63Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
29.63Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
29.63Single5X93K-87945X93-ETB-K-8794
29.63Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
29.63Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
29.63Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
29.63Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
29.63Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
29.63Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
29.63Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
29.63Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
29.63Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
29.63Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
29.63Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
29.63Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.63Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
29.63Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
29.63Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
29.63Consensusendothelin_offOrthosteric Ligandetb_off
29.63Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
29.63Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
29.63Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
29.63Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
29.41Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
29.41Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single2Y01Dobutamine2Y01-β1-Dobutamine
29.17Single2Y02Carmoterol2Y02-β1-Carmoterol
29.17Single3EMLZM-2413853EML-A2A-ZM-241385
29.17Single3NY8ICI118-5513NY8-β2-ICI118-551
29.17Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
29.17Single4GBRS-Carazolol4GBR-β2-S-Carazolol
29.17Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
29.17Single4QIMANTA XV4QIM-SMO-ANTA XV
29.17Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
29.17Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
29.17Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
29.17Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
29.17Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
29.17Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
29.17Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
29.17Single6S0LZM-2413856S0L-A2A-ZM-241385
29.17Single6TOTLemborexant6TOT-OX1-Lemborexant
29.17Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
29.17Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
29.17Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
29.17Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
29.17Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
29.17Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
29.17Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
29.17Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
29.17Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
29.17Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
29.17Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
29.17Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
29.17Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
29.17Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
29.17Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
29.17Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
29.17Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
29.17Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
29.17Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
29.17Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
29.17Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
29.17Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
29.17Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
29.17Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
29.17Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
29.17Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
29.17Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
29.17Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
29.17Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
29.17Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
29.17Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
29.17Single8RLNLUF58348RLN-A2A-LUF5834
29.17Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
29.17Single8T1WCVN4248T1W-GPR6-CVN424
29.17Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
29.17Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
29.17Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
29.17Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
29.17Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
29.17Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
29.17Consensus5ht5_onOrthosteric Ligand5ht5a_on
29.17Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
29.17Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
29.17Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
29.17Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
29.17Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
29.17Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
29.17Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
29.17Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
29.17Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
29.17Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
29.17Consensusblt_onOrthosteric Ligandblt1_on
29.17Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
29.17Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
29.17Consensusdopamine_offOrthosteric Ligandd2_off d3_off
29.17Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
29.17Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
29.17Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
29.17Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
29.17Consensusleukotriene_onOrthosteric Ligandblt_on
29.17Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
29.03Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
29.03Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
29.03Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
29.03Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
29.03Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.03Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
29.03Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
29.03Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
28.57Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
28.57Single6IGKEndothelin-36IGK-ETB-Endothelin-3
28.57Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
28.57Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
28.57Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
28.57Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
28.57Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
28.57Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
28.57Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
28.57Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
28.57Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
28.57Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
28.57Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
28.57Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
28.57Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
28.12Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
28.12Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
28.12Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
28.12Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
28.12Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
28.12Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
28.12Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
28.12Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
28.12Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.00Single2RH1S-Carazolol2RH1-β2-S-Carazolol
28.00Single2Y00Dobutamine2Y00-β1-Dobutamine
28.00Single2YCWS-Carazolol2YCW-β1-S-Carazolol
28.00Single4JKVTaladegib4JKV-SMO-Taladegib
28.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
28.00Single5D6LS-Carazolol5D6L-β2-S-Carazolol
28.00Single5JQHS-Carazolol5JQH-β2-S-Carazolol
28.00Single5N2RPSB-365N2R-A2A-PSB-36-Na
28.00Single5N2SPSB365N2S-A1-PSB36
28.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
28.00Single5TVNLSD5TVN-5-HT2B-LSD
28.00Single5WQCEMPA5WQC-OX2-EMPA
28.00Single5XPRBosentan5XPR-ETB-Bosentan
28.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
28.00Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
28.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
28.00Single6HLPNetupitant6HLP-NK1-Netupitant
28.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
28.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
28.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
28.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
28.00Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
28.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
28.00Single6TP6Filorexant6TP6-OX1-Filorexant
28.00Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
28.00Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
28.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
28.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
28.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
28.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.00Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
28.00Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
28.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
28.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
28.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
28.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
28.00Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
28.00Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
28.00Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
28.00Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.00Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.00Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
28.00Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
28.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
28.00Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
28.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
28.00Single8JXSPF-61428JXS-D1-PF-6142
28.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
28.00Single8S4DCMF-0198S4D-Apelin-CMF-019
28.00Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.00Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.00Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
28.00Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
28.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
28.00Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
28.00Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
28.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
28.00Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
28.00Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
28.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
28.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
28.00Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
28.00Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
28.00Consensusamine_offonOrthosteric Ligandamine_off amine_on
28.00Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
28.00Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
28.00Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
28.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
28.00Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
28.00Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
28.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
28.00Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
28.00Consensusdp_offOrthosteric Liganddp2_off
28.00Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
28.00Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
28.00Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
28.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.00Consensustrace-amine_onOrthosteric Ligandta1_on
27.59Single7QA8Peptide7QA8-STE2-Peptide
27.59Single7QA8Peptide7QA8-STE2-Peptide
27.59Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
27.59Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
27.59Single8IEBA1LYA8IEB-GPR156-A1LYA
27.59Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
27.59Single8WKYPG-9348WKY-MC4-PG-934
27.59Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
27.59Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.59Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
27.59Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
27.59Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
27.59Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
27.59Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
27.27Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
27.27Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
27.27Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
27.27Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
27.27Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
27.27Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
27.27Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
27.27Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
27.27Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
27.27Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
27.27Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
27.27Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
27.27Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
27.27Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
27.27Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
27.27Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
27.27Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
26.92Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
26.92Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
26.92Single4DJHJDTic4DJH-κ-JDTic
26.92Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
26.92Single4U15Tiotropium4U15-M3-Tiotropium
26.92Single5D5AS-Carazolol5D5A-β2-S-Carazolol
26.92Single5D5BS-Carazolol5D5B-β2-S-Carazolol
26.92Single5V57TC1145V57-SMO-TC114
26.92Single5XRAAM115425XRA-CB1-AM11542
26.92Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
26.92Single6E59L-7607356E59-NK1-L-760735
26.92Single6H7JIsoprenaline6H7J-β1-Isoprenaline
26.92Single6J20Aprepitant6J20-NK1-Aprepitant
26.92Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
26.92Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
26.92Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
26.92Single6OL9Tiotropium6OL9-M5-Tiotropium
26.92Single6TQ7SB-3348676TQ7-OX1-SB-334867
26.92Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
26.92Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
26.92Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
26.92Single7FEECP559407FEE-CB1-CP55940-ZCZ011
26.92Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
26.92Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
26.92Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
26.92Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
26.92Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
26.92Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
26.92Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
26.92Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
26.92Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
26.92Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
26.92Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
26.92Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
26.92Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
26.92Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
26.92Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
26.92Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
26.92Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
26.92Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
26.92Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
26.92Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
26.92Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
26.92Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
26.92Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.92Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
26.92Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
26.92Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
26.92Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
26.92Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
26.92Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
26.92Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
26.92Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
26.92Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
26.92Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
26.92Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
26.92Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
26.92Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
26.92Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
26.92Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
26.92Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
26.92Consensuslpa_onOrthosteric Ligandlpa1_on
26.92Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
26.92Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
26.92Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
26.92Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
26.92Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
26.92Consensusrelaxin_onOrthosteric Ligandrxfp4_on
26.92Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
26.92Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.92Consensustachykinin_offOrthosteric Ligandnk1_off
26.92Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
26.67Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
26.67Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
26.67Single8IEBA1LYA8IEB-GPR156-A1LYA
26.67Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
26.67Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
26.67Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
26.67Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
26.67Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
26.47Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
26.47Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
26.09Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
26.09Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
26.09Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
26.09Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
26.09Single5ZKQABT-4915ZKQ-PAF-ABT-491
26.09Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
26.09Single6DS0Ly2660976DS0-5-HT2B-Ly266097
26.09Single6ME2Ramelteon6ME2-MT1-Ramelteon
26.09Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
26.09Single7F8ULintitript7F8U-CCKA-Lintitript
26.09Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
26.09Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
26.09Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
26.09Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
26.09Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
26.09Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
26.09Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
26.09Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
26.09Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
26.09Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
26.09Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
26.09Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
26.09Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
26.09Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
26.09Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
26.09Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
26.09Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
26.09Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
26.09Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
26.09Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
26.09Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
26.09Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
26.09Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
26.09Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
26.09Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
26.09Consensusalpha2_offOrthosteric Ligandalpha2c_off
26.09Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
26.09Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
26.09Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
26.09Consensusorexin_offOrthosteric Ligandox2_off ox1_off
26.09Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
26.09Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
25.93Single3D4STimolol3D4S-β2-Timolol
25.93Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
25.93Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
25.93Single5CXVTiotropium5CXV-M1-Tiotropium
25.93Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
25.93Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
25.93Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
25.93Single6KQICP559406KQI-CB1-CP55940-Org27569
25.93Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
25.93Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
25.93Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
25.93Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
25.93Single7DFPSpiperone7DFP-D2-Spiperone
25.93Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
25.93Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
25.93Single7K15MKD0467K15-BLT1-MKD046-Na
25.93Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
25.93Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
25.93Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.93Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
25.93Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
25.93Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
25.93Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
25.93Single8XYIVUF106618XYI-CXCR3-VUF10661
25.93Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
25.93Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
25.93Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
25.93Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
25.93Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
25.93Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
25.93Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
25.93Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
25.93Consensuslpa_offOrthosteric Ligandlpa1_off
25.93Consensuslpl_offOrthosteric Ligands1p_off lpa_off
25.93Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
25.93Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
25.93Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
25.93Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
25.81Single3OE0CVX153OE0-CXCR4-CVX15
25.81Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
25.81Single6W25SHU91196W25-MC4-SHU9119-Ca
25.81Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
25.81Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
25.81Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.81Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
25.81Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
25.71Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
25.00Single2YDOAdenosine2YDO-A2A-Adenosine
25.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
25.00Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
25.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
25.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
25.00Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
25.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
25.00Single5UVIZM-2413855UVI-A2A-ZM-241385
25.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
25.00Single6KUXRS-799486KUX-α2a-RS-79948
25.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
25.00Single6MH8ZM-2413856MH8-A2A-ZM-241385
25.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
25.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
25.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
25.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
25.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
25.00Single6TPNHTL66416TPN-OX2-HTL6641
25.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
25.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
25.00Single6VI4JDTic6VI4-κ-JDTic
25.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
25.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
25.00Single7AROLUF58337ARO-A2A-LUF5833-Na
25.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
25.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
25.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
25.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
25.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
25.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
25.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
25.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
25.00Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
25.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
25.00Single7UL3Famotidine7UL3-H2-Famotidine
25.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
25.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
25.00Single7VV6C48/807VV6-MRGPRX2-C48/80
25.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
25.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
25.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
25.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
25.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.00Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
25.00Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
25.00Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
25.00Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
25.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
25.00Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
25.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
25.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
25.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
25.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
25.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
25.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
25.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
25.00Single8K5CAcipimox8K5C-HCA2-Acipimox
25.00Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
25.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
25.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
25.00Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
25.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
25.00Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
25.00Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
25.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
25.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
25.00Single8XVUCXCL28XVU-CXCR2-CXCL2
25.00Single8XWFCXCL38XWF-CXCR2-CXCL3
25.00Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
25.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
25.00Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
25.00Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
25.00Single9BJKNaloxone9BJK-μ-Naloxone-NAM
25.00Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
25.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
25.00Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
25.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
25.00Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.00Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.00Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
25.00Consensuschemerin_onOrthosteric Ligandcml1_on
25.00Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
25.00Consensushca_onOrthosteric Ligandhca2_on
25.00Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
25.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
24.24Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
24.24Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
24.24Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
24.24Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
24.24Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
24.24Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
24.14Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
24.14Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
24.14Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
24.14Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
24.14Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
24.14Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
24.14Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
24.14Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
24.14Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
24.14Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
24.14Single8XQJJN2418XQJ-Apelin-JN241
24.14Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
24.14Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
24.14Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
24.14Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
24.14Consensuskisspeptin_onOrthosteric Ligandkiss1_on
24.14Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
24.00Single2Y04Salbutamol2Y04-β1-Salbutamol
24.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
24.00Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
24.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
24.00Single4DAJTiotropium4DAJ-M3-Tiotropium
24.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
24.00Single4MQSIperoxo4MQS-M2-Iperoxo
24.00Single4U14Tiotropium4U14-M3-Tiotropium
24.00Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
24.00Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
24.00Single5DHHSB-6121115DHH-NOP-SB-612111
24.00Single5DSGTiotropium5DSG-M4-Tiotropium
24.00Single5UENDU1725UEN-A1-DU172
24.00Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
24.00Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
24.00Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
24.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
24.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
24.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
24.00Single6H7MSalbutamol6H7M-β1-Salbutamol
24.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
24.00Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
24.00Single6PS1Timolol6PS1-β2-Timolol
24.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00Single7BU7BI1671077BU7-β1-BI167107
24.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
24.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
24.00Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
24.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
24.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
24.00Single7UL4Alvimopan7UL4-μ-Alvimopan
24.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
24.00Single7V3ZCP559407V3Z-CB1-CP55940
24.00Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
24.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
24.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
24.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
24.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
24.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
24.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
24.00Single8CU6LJ-45178CU6-A2A-LJ-4517
24.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
24.00Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
24.00Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
24.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
24.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
24.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
24.00Single8JJOAlprenolol8JJO-β2-Alprenolol
24.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
24.00Single8JXRLSD8JXR-D1-LSD
24.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
24.00Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
24.00Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
24.00Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
24.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
24.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
24.00Single8X63Mepyramine8X63-H1-Mepyramine
24.00Single8X64Desloratadine8X64-H1-Desloratadine
24.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
24.00Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
24.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
24.00Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
24.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
24.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
24.00Consensusalpha2_onOrthosteric Ligandalpha2b_on
24.00Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
24.00Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
24.00Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
24.00Consensuscck_offOrthosteric Ligandccka_off
24.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
24.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
24.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
24.00Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
24.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
24.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
24.00Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
24.00Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
24.00Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
24.00Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
24.00Consensushca_on_gpOrthosteric Ligandhca2_on_gp
24.00Consensushistamine_offOrthosteric Ligandh1_off
24.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
24.00Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
24.00Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
23.81Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
23.81Single9CHUNoradrenaline9CHU-β2-Noradrenaline
23.81Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
23.81Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
23.53Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
23.53Single6FJ3PTH6FJ3-PTH1-PTH
23.53Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
23.53Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
23.53Single7SK3CXCL127SK3-ACKR3-CXCL12
23.53Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
23.53Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
23.33Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
23.33Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
23.33Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
23.33Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
23.33Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
23.33Single8IEPA1LYA8IEP-GPR156-A1LYA
23.33Single8IEPA1LYA8IEP-GPR156-A1LYA
23.33Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
23.33Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
23.33Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
23.33Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
23.33Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
23.33Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
23.33Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
23.33Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
23.33Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
23.08Single2Y03Isoprenaline2Y03-β1-Isoprenaline
23.08Single4NTJAZD12834NTJ-P2Y12-AZD1283
23.08Single5WIUNemonapride5WIU-D4-Nemonapride
23.08Single5WIVNemonapride5WIV-D4-Nemonapride-Na
23.08Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
23.08Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
23.08Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
23.08Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
23.08Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
23.08Single6PS6Timolol6PS6-β2-Timolol
23.08Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
23.08Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
23.08Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
23.08Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
23.08Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.08Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
23.08Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
23.08Single7W41PD1762527W41-BB2-PD176252
23.08Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
23.08Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
23.08Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
23.08Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
23.08Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
23.08Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
23.08Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
23.08Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
23.08Consensusbombesin_offOrthosteric Ligandbb2_off
23.08Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
23.08Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
23.08Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
23.08Consensusep_offOrthosteric Ligandep4_off
23.08Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.08Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.08Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.08Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.08Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
23.08Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
23.08Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
22.86Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
22.86Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
22.86Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
22.73Single3UZAGTPL92363UZA-A2A-GTPL9236
22.73Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
22.73Single6ME5Agomelatine6ME5-MT1-Agomelatine
22.73Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
22.73Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
22.73Single7WC5Psilocin7WC5-5-HT2A-Psilocin
22.73Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
22.73Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
22.73Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
22.73Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
22.73Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
22.73Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
22.73Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
22.73Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
22.73Consensus5ht2_onOrthosteric Ligand5ht2b_on
22.73Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
22.73Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
22.73Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
22.73Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
22.73Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
22.58Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
22.58Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
22.58Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
22.58Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
22.58Single7XNACYN1548067XNA-SST2-CYN154806
22.58Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
22.58Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
22.58Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
22.58Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
22.58Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
22.58Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
22.58Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
22.22Single5V54Methiothepin5V54-5-HT1B-Methiothepin
22.22Single5XR8AM8415XR8-CB1-AM841
22.22Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
22.22Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
22.22Single6OS1TRV0266OS1-AT1-TRV026
22.22Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
22.22Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
22.22Single7B6WCyclazosin7B6W-α1b-Cyclazosin
22.22Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
22.22Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
22.22Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
22.22Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
22.22Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
22.22Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8EA0Iperoxo8EA0-M3-Iperoxo
22.22Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
22.22Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
22.22Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
22.22Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
22.22Single8XVLZibotentan8XVL-ETA-Zibotentan
22.22Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
22.22Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
22.22Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
22.22Consensus5ht1_offOrthosteric Ligand5ht1b_off
22.22Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
22.22Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
22.22Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
22.22Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
22.22Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
22.22Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
21.88Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
21.88Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
21.88Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
21.74Single3PBLEticlopride3PBL-D3-Eticlopride
21.74Single5L7IVismodegib5L7I-SMO-Vismodegib
21.74Single6HLLCP999946HLL-NK1-CP99994
21.74Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
21.74Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
21.74Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
21.74Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
21.74Single7SRQLSD7SRQ-5-HT2B-LSD
21.74Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
21.74Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
21.74Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
21.74Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
21.74Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
21.74Single8K5BNiacin8K5B-HCA2-Niacin
21.74Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
21.74Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
21.74Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
21.74Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
21.74Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
21.74Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
21.74Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
21.74Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
21.74Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
21.74Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
21.74Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
21.43Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
21.43Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
21.43Single4PY02MeSATP4PY0-P2Y12-2MeSATP
21.43Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
21.43Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
21.43Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
21.43Single6CM4Risperidone6CM4-D2-Risperidone
21.43Single6OS2TRV0266OS2-AT1-TRV026
21.43Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
21.43Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
21.43Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
21.43Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
21.43Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
21.43Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
21.43Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
21.43Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.43Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
21.43Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
21.43Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
21.43Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
21.43Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
21.43Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
21.43Single8XWACXCL18XWA-CXCR2-CXCL1
21.43Single8XWMCXCL68XWM-CXCR2-CXCL6
21.43Single8XWSCXCL58XWS-CXCR2-CXCL5
21.43Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
21.43Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
21.43Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
21.43Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
21.43Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
21.43Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
21.43Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
21.43Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
21.43Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
21.43Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.43Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.21Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
21.21Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
21.21Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
21.21Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
21.21Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
20.83Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
20.83Single4S0VSuvorexant4S0V-OX2-Suvorexant
20.83Single5WS3EMPA5WS3-OX2-EMPA
20.83Single6B73MP11046B73-κ-MP1104
20.83Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
20.83Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
20.83Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
20.83Single6ME9Ramelteon6ME9-MT2-Ramelteon
20.83Single6TODEMPA6TOD-OX1-EMPA-Na
20.83Single6TPJSuvorexant6TPJ-OX2-Suvorexant
20.83Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
20.83Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
20.83Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
20.83Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
20.83Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
20.83Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
20.83Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
20.83Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
20.83Single7XRRLemborexant7XRR-OX2-Lemborexant
20.83Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
20.83Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
20.83Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
20.83Single8GNGIstradefylline8GNG-A2A-Istradefylline
20.83Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
20.83Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
20.83Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
20.83Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
20.83Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
20.83Single8IWESpermidine8IWE-TA9-Spermidine
20.83Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
20.83Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
20.83Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
20.83Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
20.83Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
20.83Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
20.83Single8Y0HVUF114188Y0H-CXCR3-VUF11418
20.83Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
20.83Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
20.83Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
20.83Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
20.83Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
20.83Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
20.83Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
20.83Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
20.83Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
20.69Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
20.69Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
20.69Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
20.69Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
20.69Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
20.69Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
20.69Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
20.69Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
20.69Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
20.69Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
20.69Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
20.69Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
20.69Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
20.69Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.69Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.59Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
20.59Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
20.59Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
20.59Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
20.59Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
20.59Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
20.59Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.00Single3RZECidoxepin3RZE-H1-Cidoxepin
20.00Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
20.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
20.00Single4XT3Fractalkine4XT3-US28-Fractalkine
20.00Single6A94Zotepine6A94-5-HT2A-Zotepine
20.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
20.00Single6IQLL7458706IQL-D4-L745870
20.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
20.00Single6TPKRetosiban6TPK-OT-Retosiban
20.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
20.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
20.00Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
20.00Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
20.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
20.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
20.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
20.00Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8IEIA1LYA8IEI-GPR156-A1LYA
20.00Single8IHKAcifran8IHK-HCA3-Acifran
20.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
20.00Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
20.00Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
20.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
20.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
20.00Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
20.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
20.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
20.00Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
20.00Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
20.00Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
20.00Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
20.00Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
20.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
20.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
20.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
20.00Consensusgrh_offOrthosteric Ligandgnrh1_off
20.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
20.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
20.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
20.00Consensusvasop-oxy_offOrthosteric Ligandot_off
19.35Single4XT1Fractalkine4XT1-US28-Fractalkine
19.35Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
19.35Single8IEIA1LYA8IEI-GPR156-A1LYA
19.35Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
19.35Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.35Consensussomatostatin_offOrthosteric Ligandsst2_off
19.23Single4QKX35V4QKX-β2-35V
19.23Single5DHGC-355DHG-NOP-C-35
19.23Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
19.23Single5TGZAM65385TGZ-CB1-AM6538
19.23Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
19.23Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
19.23Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
19.23Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
19.23Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
19.23Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
19.23Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
19.23Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.23Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
19.23Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
19.23Single8K5DGSK2560738K5D-HCA2-GSK256073
19.23Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
19.23Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
19.23Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
19.23Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
19.23Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
19.23Single9B9ZA1AKO9B9Z-CB1-A1AKO
19.23Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
19.23Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
19.23Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
19.23Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
19.05Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
19.05Single8PWNTheophylline8PWN-A2A-Theophylline
19.05Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
18.92Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
18.92Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
18.92Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
18.92Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
18.75Single7SK5CXCL127SK5-ACKR3-CXCL12
18.75Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
18.75Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
18.52Single6GPXMK08126GPX-CCR2-MK0812
18.52Single7C4SS1P7C4S-S1P3-S1P
18.52Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
18.52Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
18.52Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
18.52Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.52Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
18.52Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
18.52Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
18.52Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
18.52Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
18.52Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
18.52Single8ZMFA1L108ZMF-5-HT2C-A1L10
18.52Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
18.52Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
18.52Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
18.52Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
18.52Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
18.52Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.52Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.52Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
18.52Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
18.42Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
18.18Single3RFMCaffeine3RFM-A2A-Caffeine
18.18Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
18.18Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
18.18Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
18.18Single8A2OTheophylline8A2O-A2A-Theophylline-Na
18.18Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
18.18Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
18.18Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
18.18Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
18.18Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.18Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
17.95Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
17.86Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
17.86Single4BV0Neurotensin4BV0-NTS1-Neurotensin
17.86Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
17.86Single5TZRMK86665TZR-FFA1-MK8666
17.86Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
17.86Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
17.86Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
17.86Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
17.86Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
17.86Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
17.86Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
17.86Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
17.86Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
17.86Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
17.86Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
17.86Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
17.86Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
17.86Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
17.86Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
17.86Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
17.86Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
17.86Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
17.86Consensusneurotensin_onOrthosteric Ligandnts1_on
17.86Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
17.86Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.86Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
17.65Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
17.65Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
17.50Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
17.50Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.39Single3OE6IT1t3OE6-CXCR4-IT1t
17.39Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
17.39Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
17.39Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
17.39Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
17.39Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.39Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
17.39Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.39Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.39Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
17.39Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
17.39Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
17.39Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
17.24Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
17.24Single4XEENeurotensin4XEE-NTS1-Neurotensin
17.24Single4XESNeurotensin4XES-NTS1-Neurotensin
17.24Single6ZG4HTL00099366ZG4-M1-HTL0009936
17.24Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
17.24Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
17.24Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.24Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
17.24Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
17.24Single8XQJJN2418XQJ-Apelin-JN241
17.24Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.24Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.14Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
17.14Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
17.14Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
17.07Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
17.07Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
16.67Single3OE9IT1t3OE9-CXCR4-IT1t
16.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
16.67Single4O9RCyclopamine4O9R-SMO-Cyclopamine
16.67Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
16.67Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
16.67Single6K1QIRL25006K1Q-ETB-IRL2500
16.67Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
16.67Single6TP4ACT-4622066TP4-OX1-ACT-462206
16.67Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
16.67Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
16.67Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
16.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
16.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.67Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
16.67Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
16.67Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
16.67Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
16.67Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
16.67Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
16.67Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
16.67Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
16.67Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
16.67Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
16.67Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
16.67Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8XVJMacitentan8XVJ-ETA-Macitentan
16.67Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
16.67Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
16.67Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
16.67Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single9B9Y7DY9B9Y-CB1-7DY
16.67Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
16.67Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
16.67Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
16.67Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.67Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
16.22Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
16.22Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
16.22Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
16.22Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
16.22Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
16.13Single5EE7MK08935EE7-Glucagon-MK0893
16.13Single6KNMJN241-96KNM-Apelin-JN241-9
16.13Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
16.13Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
16.13Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
16.00Single3ODUIT1t3ODU-CXCR4-IT1t
16.00Single4QINSAG1.54QIN-SMO-SAG1.5
16.00Single5U09Taranabant5U09-CB1-Taranabant
16.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
16.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
16.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
16.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
16.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
16.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
16.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
16.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
16.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
16.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
16.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
16.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
16.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
16.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
16.00Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
16.00Single9BA0A1AKN9BA0-CB1-A1AKN
16.00Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
16.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
16.00Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
16.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
16.00Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
16.00Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
15.91Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
15.79Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
15.79Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
15.79Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
15.79Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
15.79Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
15.79Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
15.62Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
15.62Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.62Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
15.62Single8KIGSHU91198KIG-MC3-SHU9119-Ca
15.62Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
15.62Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
15.38Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
15.38Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
15.38Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
15.38Single6V9SGTPL114036V9S-OX1-GTPL11403
15.38Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
15.38Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
15.38Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
15.38Single7VODCariprazine7VOD-5-HT2A-Cariprazine
15.38Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.38Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
15.38Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
15.38Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8K2WAMG4878K2W-CXCR3-AMG487
15.38Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
15.38Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
15.38Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
15.38Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
15.38Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
15.38Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
15.38Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
15.38Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
15.38Consensusopsins_offOrthosteric Ligandrhodopsin_off
15.38Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.38Consensussensory_offOrthosteric Ligandopsins_off
15.15Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.00Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
15.00Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
15.00Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
15.00Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
14.81Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
14.81Single4YAYZD-71554YAY-AT1-ZD-7155
14.81Single5T04Neurotensin5T04-NTS1-Neurotensin
14.81Single6D27CAY104716D27-DP2-CAY10471
14.81Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
14.81Single6GPSMK08126GPS-CCR2-MK0812
14.81Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
14.81Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
14.81Single7YXAONO-54306087YXA-S1P5-ONO-5430608
14.81Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
14.81Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
14.81Single9IYAONO-97105319IYA-GPR55-ONO-9710531
14.81Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
14.71Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
14.63Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
14.29Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
14.29Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
14.29Single5MZPCaffeine5MZP-A2A-Caffeine-Na
14.29Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
14.29Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
14.29Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
14.29Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
14.29Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
14.29Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
14.29Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
14.29Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29Single7SINNPS-21437SIN-CaS-NPS-2143
14.29Single7SINNPS-21437SIN-CaS-NPS-2143
14.29Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
14.29Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
14.29Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
14.29Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
14.29Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
14.29Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
14.29Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
14.29Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
14.29Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
14.29Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
14.29Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
14.29Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
14.29Consensusblt_offOrthosteric Ligandblt1_off
13.95Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.89Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
13.89Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
13.89Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
13.89Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
13.79Single7F1TMIP-1a7F1T-CCR5-MIP-1a
13.79Single7P2L4YI7P2L-mGlu5-4YI
13.79Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
13.79Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
13.79Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
13.79Single9BJKNAM9BJK-μ-Naloxone-NAM
13.64Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
13.64Single7WC4Serotonin7WC4-5-HT2A-Serotonin
13.51Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
13.51Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
13.51Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
13.33Single5X33BIIL2605X33-BLT1-BIIL260
13.33Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
13.33Single6YVRNTS8-136YVR-NTS1-NTS8-13
13.33Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
13.33Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
13.33Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
13.33Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
13.16Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
13.16Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
13.16Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
13.16Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
13.16Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
13.16Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
13.04Single6TQ9SB-4081246TQ9-OX1-SB-408124
13.04Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
13.04Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
13.04Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
12.90Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
12.90Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
12.90Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
12.90Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
12.90Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
12.90Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
12.90Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
12.82Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
12.82Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
12.82Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
12.50Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
12.50Single4XNWMRS25004XNW-P2Y1-MRS2500
12.50Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
12.50Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
12.50Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
12.50Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
12.50Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
12.50Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
12.50Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
12.50Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
12.50Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
12.50Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
12.50Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
12.20Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
12.20Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
12.20Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
12.12Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
12.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
12.00Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
12.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
12.00Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
12.00Single6LI0C176LI0-GPR52-C17
12.00Single7UL2SR486927UL2-NTS1-SR48692-Na
12.00Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
12.00Consensusgq_nucleotideOrthosteric Ligandgq_p2y
12.00Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
12.00Consensusneurotensin_offOrthosteric Ligandnts1_off
12.00Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
11.90Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
11.90Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
11.90Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
11.63Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
11.54Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
11.54Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
11.54Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
11.54Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
11.54Single4BWBNeurotensin4BWB-NTS1-Neurotensin
11.54Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.54Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
11.54Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
11.54Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.54Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.54Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.54Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
11.54Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
11.54Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
11.54Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
11.54Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
11.54Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
11.54Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
11.54Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
11.54Consensusangiotensin_offOrthosteric Ligandat1_off
11.54Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
11.54Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
11.54Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.54Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
11.54Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
11.43Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
11.11Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
11.11Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
11.11Single6FFIMMPEP6FFI-mGlu5-MMPEP
11.11Single6ZG9GSK10347026ZG9-M1-GSK1034702
11.11Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
11.11Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
11.11Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
11.11Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
11.11Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
11.11Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
10.71Single6FFHFenobam6FFH-mGlu5-Fenobam
10.71Single6IIVDaltroban6IIV-TP-Daltroban
10.71Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
10.71Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
10.71Single7F83PF-051904577F83-Ghrelin-PF-05190457
10.71Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
10.71Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
10.71Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
10.71Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
10.71Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
10.71Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
10.71Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
10.64Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
10.53Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
10.42Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
10.34Single5CGCHTL142425CGC-mGlu5-HTL14242
10.34Single6LUQHaloperidol6LUQ-D2-Haloperidol
10.34Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
10.34Single6Z4SSR486926Z4S-NTS1-SR48692
10.34Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
10.34Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
10.26Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
10.26Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
10.26Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
10.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
10.00Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
10.00Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
10.00Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
10.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
10.00Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
9.68Single6IIURamatroban6IIU-TP-Ramatroban
9.68Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
9.38Single5CGDHTL142425CGD-mGlu5-HTL14242
9.38Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
9.09Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
9.09Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
9.09Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
9.09Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
9.09Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
9.09Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
9.09Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
9.09Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
8.82Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
8.82Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
8.70Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
8.70Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
8.70Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
8.70Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
8.57Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
8.33Single3OE8IT1t3OE8-CXCR4-IT1t
8.33Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
8.33Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
8.33Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
8.33Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
8.33Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
8.33Consensusp2y_offOrthosteric Ligandp2y1_off
8.33Consensussensory_onOrthosteric Ligandopsins_on
8.11Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
8.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
8.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
8.00Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
8.00Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
8.00Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
8.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.00Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
8.00Single8JPSCCL78JPS-ACKR1-CCL7
8.00Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
8.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
8.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
8.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
8.00Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.00Consensusgi_sensoryOrthosteric Ligandgi_opsins
8.00Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.00Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.00Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
8.00Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
8.00Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
7.89Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
7.69Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
7.69Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
7.69Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
7.69Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
7.69Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.69Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
7.41Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
7.41Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
7.41Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
7.41Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
7.41Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
7.41Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
7.32Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
7.14Single6ZINSR486926ZIN-NTS1-SR48692
7.14Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
7.14Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
6.90Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
6.90Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
6.67Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
6.67Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
6.67Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
6.45Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
6.45Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
6.25Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
6.06Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
5.71Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
5.56Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
5.56Single7SHEPI; PE7SHE-GPR158-PI; PE
5.56Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
5.13Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
5.00Single8W8SAA-148W8S-GPR101-AA-14
4.76Single8W8RAA-148W8R-GPR101-AA-14-chim(NtGi1-Gs)/β1/γ2
4.55Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.17Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
4.17Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
4.17Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
4.00Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
4.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
4.00Single8IKGQ2B8IKG-CB1-Q2B-Gi1/β1/γ1
3.85Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
3.70Single7FEEZCZ0117FEE-CB1-CP55940-ZCZ011
3.70Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
3.70Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
3.70Single8IKHQ2L8IKH-CB1-Q2L-Gi1/β1/γ1
3.70Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
3.57Single4XNVBPTU4XNV-P2Y1-BPTU
3.57Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.57Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
3.57Single7WV9ZCZ0117WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
3.45Single8IYXYL-3658IYX-GPR34-YL-365
3.03Single7SHEPI; PE7SHE-GPR158-PI; PE
2.94Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

PDB Summary
PDB 7KH0
Class A
SubFamily Peptide
Type Vasopressin and Oxytocin
SubType V2
Species Homo Sapiens
Ligand AVP
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 2.8
Date 2021-05-26
D.O.I. 10.1038/s41422-021-00483-z
Net Summary
Imin 2.26
Number of Linked Nodes 854
Number of Links 1068
Number of Hubs 195
Number of Links mediated by Hubs 699
Number of Communities 27
Number of Nodes involved in Communities 266
Number of Links involved in Communities 389
Path Summary
Number Of Nodes in MetaPath 108
Number Of Links MetaPath 107
Number of Shortest Paths 916032
Length Of Smallest Path 3
Average Path Length 27.046
Length of Longest Path 72
Minimum Path Strength 1.22
Average Path Strength 5.40319
Maximum Path Strength 20.52
Minimum Path Correlation 0.7
Average Path Correlation 0.980388
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.88679
Average % Of Corr. Nodes 49.3494
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.7105
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• regulation of body fluid levels   • hemostasis   • biological regulation   • regulation of biological quality   • regulation of tube diameter   • multicellular organismal process   • regulation of biological process   • system process   • regulation of tube size   • regulation of system process   • positive regulation of biological process   • positive regulation of vasoconstriction   • circulatory system process   • regulation of blood circulation   • vascular process in circulatory system   • regulation of vasoconstriction   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • blood vessel diameter maintenance   • vasoconstriction   • blood circulation   • regulation of anatomical structure size   • regulation of biosynthetic process   • regulation of cellular process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • biosynthetic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • cellular process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • cellular response to stimulus   • response to stimulus   • signaling   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to endogenous stimulus   • response to chemical   • cellular response to hormone stimulus   • response to peptide   • response to cytokine   • regulation of systemic arterial blood pressure by hormone   • regulation of systemic arterial blood pressure mediated by a chemical signal   • regulation of blood pressure   • regulation of systemic arterial blood pressure   • endocrine process   • regulation of systemic arterial blood pressure by vasopressin   • cell population proliferation   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • positive regulation of cell communication   • regulation of signaling   • positive regulation of signal transduction   • positive regulation of intracellular signal transduction   • regulation of signal transduction   • intracellular signal transduction   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • regulation of response to stimulus   • regulation of cell communication   • positive regulation of signaling   • renal system process   • regulation of urine volume   • renal water retention   • negative regulation of urine volume   • developmental process   • head development   • forebrain development   • animal organ development   • brain development   • nervous system development   • multicellular organism development   • central nervous system development   • anatomical structure development   • telencephalon development   • system development   • negative regulation of cell population proliferation   • negative regulation of cellular process   • negative regulation of biological process   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • positive regulation of systemic arterial blood pressure   • positive regulation of blood pressure   • cellular anatomical structure   • membrane   • membrane-bounded organelle   • intracellular anatomical structure   • intracellular vesicle   • intracellular organelle   • bounding membrane of organelle   • cytoplasmic vesicle   • vesicle membrane   • clathrin-coated vesicle   • endocytic vesicle membrane   • coated vesicle   • vesicle   • endocytic vesicle
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • membrane-bounded organelle   • intracellular anatomical structure   • intracellular vesicle   • intracellular organelle   • bounding membrane of organelle   • cytoplasmic vesicle   • vesicle membrane   • clathrin-coated vesicle   • endocytic vesicle membrane   • coated vesicle   • vesicle   • endocytic vesicle   • clathrin-coated vesicle membrane   • clathrin-coated endocytic vesicle membrane   • intracellular membrane-bounded organelle   • clathrin-coated endocytic vesicle   • cytoplasmic vesicle membrane   • coated vesicle membrane   • organelle   • cytoplasm   • organelle membrane   • cell periphery   • plasma membrane   • Golgi apparatus   • endomembrane system   • endosome   • perinuclear region of cytoplasm   • endoplasmic reticulum   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • lysosomal membrane   • lysosome   • synapse   • cell junction   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • GDP binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • skeletal system development   • bone development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cell division   • negative regulation of lyase activity   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • positive regulation of autophagy   • catabolic process   • macroautophagy   • autophagy   • regulation of catabolic process   • regulation of autophagy   • positive regulation of catabolic process   • regulation of macroautophagy   • positive regulation of macroautophagy   • process utilizing autophagic mechanism   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • nucleoside phosphate metabolic process   • ribose phosphate metabolic process   • purine nucleoside triphosphate metabolic process   • GTP metabolic process   • carbohydrate derivative metabolic process   • primary metabolic process   • nucleotide metabolic process   • purine-containing compound metabolic process   • nucleobase-containing compound metabolic process   • purine nucleotide metabolic process   • ribonucleotide metabolic process   • organophosphate metabolic process   • nucleobase-containing small molecule metabolic process   • purine ribonucleoside triphosphate metabolic process   • phosphate-containing compound metabolic process   • small molecule metabolic process   • nucleoside triphosphate metabolic process   • purine ribonucleotide metabolic process   • phosphorus metabolic process   • ribonucleoside triphosphate metabolic process   • Golgi apparatus subcompartment   • organelle subcompartment   • trans-Golgi network membrane   • trans-Golgi network   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • ciliary basal body   • vasopressin receptor binding   • V1B vasopressin receptor binding   • molecular transducer activity   • signaling receptor activity   • neuropeptide activity   • signaling receptor activator activity   • hormone activity   • neuropeptide hormone activity   • signaling receptor regulator activity   • receptor ligand activity   • neurohypophyseal hormone activity   • V1A vasopressin receptor binding   • catalytic activity, acting on a protein   • kinase activity   • protein kinase activity   • transferase activity   • phosphotransferase activity, alcohol group as acceptor   • transferase activity, transferring phosphorus-containing groups   • regulation of growth   • regulation of cellular component organization   • positive regulation of cell growth   • regulation of cell growth   • cell growth   • cellular component organization   • positive regulation of growth   • cellular component organization or biogenesis   • positive regulation of cytosolic calcium ion concentration   • behavior   • locomotory behavior   • reproductive process   • negative regulation of female receptivity   • multicellular organismal reproductive process   • female mating behavior   • mating behavior   • regulation of female receptivity   • reproductive behavior   • negative regulation of nervous system process   • regulation of system process   • transmission of nerve impulse   • negative regulation of transmission of nerve impulse   • negative regulation of cell communication   • regulation of nervous system process   • regulation of transmission of nerve impulse   • negative regulation of cellular process   • negative regulation of multicellular organismal process   • regulation of tube diameter   • regulation of tube size   • positive regulation of vasoconstriction   • circulatory system process   • regulation of blood circulation   • vascular process in circulatory system   • regulation of vasoconstriction   • blood vessel diameter maintenance   • vasoconstriction   • blood circulation   • regulation of anatomical structure size   • negative regulation of programmed cell death   • regulation of apoptotic process   • regulation of programmed cell death   • cell death   • negative regulation of apoptotic process   • apoptotic process   • programmed cell death   • regulation of biosynthetic process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • biosynthetic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • response to testosterone   • biological process involved in interspecies interaction between organisms   • symbiont entry into host cell   • viral process   • symbiont entry into host   • viral life cycle   • biological process involved in interaction with host   • biological process involved in symbiotic interaction   • maternal behavior   • parental behavior   • fluid transport   • water transport   • generation of precursor metabolites and energy   • positive regulation of cellular pH reduction   • intracellular pH reduction   • regulation of intracellular pH   • cellular homeostasis   • regulation of cellular pH reduction   • intracellular monoatomic cation homeostasis   • regulation of pH   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • regulation of cellular pH   • intracellular monoatomic ion homeostasis   • response to ethanol   • prostaglandin metabolic process   • unsaturated fatty acid metabolic process   • oxoacid metabolic process   • regulation of lipid metabolic process   • organic acid biosynthetic process   • organic acid metabolic process   • carboxylic acid biosynthetic process   • regulation of primary metabolic process   • regulation of small molecule metabolic process   • positive regulation of lipid metabolic process   • positive regulation of prostaglandin biosynthetic process   • prostaglandin biosynthetic process   • regulation of ketone metabolic process   • regulation of fatty acid metabolic process   • regulation of fatty acid biosynthetic process   • monocarboxylic acid metabolic process   • positive regulation of unsaturated fatty acid biosynthetic process   • regulation of prostaglandin biosynthetic process   • icosanoid metabolic process   • ketone metabolic process   • regulation of unsaturated fatty acid biosynthetic process   • lipid biosynthetic process   • positive regulation of fatty acid biosynthetic process   • prostanoid metabolic process   • icosanoid biosynthetic process   • prostanoid biosynthetic process   • positive regulation of fatty acid metabolic process   • fatty acid metabolic process   • monocarboxylic acid biosynthetic process   • small molecule biosynthetic process   • carboxylic acid metabolic process   • fatty acid biosynthetic process   • unsaturated fatty acid biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • lipid metabolic process   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • maternal aggressive behavior   • aggressive behavior   • biological process involved in intraspecies interaction between organisms   • social behavior   • positive regulation of systemic arterial blood pressure   • regulation of systemic arterial blood pressure   • regulation of blood pressure   • positive regulation of blood pressure   • response to nicotine   • regulation of glutamate secretion   • positive regulation of secretion by cell   • positive regulation of amine transport   • positive regulation of secretion   • regulation of amino acid transport   • glutamate secretion   • organic anion transport   • carboxylic acid transport   • positive regulation of glutamate secretion   • positive regulation of organic acid transport   • organic acid transport   • amino acid transport   • amine transport   • acidic amino acid transport   • positive regulation of transport   • positive regulation of amino acid transport   • regulation of organic acid transport   • dicarboxylic acid transport   • regulation of amine transport   • grooming behavior   • dense core granule   • secretory granule   • secretory vesicle   • neuronal dense core vesicle   • somatodendritic compartment   • dendrite   • dendritic tree   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7KH0_Chain_A
TLSAEDKAA VERSKMIEK QLQKDKQVY RATHRLLLL GAGESGKST 
IVKQMSGIF ETKFQVDKV NFHMFDVGG QRDERRKWI QCFNDVTAI 
IFVVASSQT NRLQEALNL FKSIWNNRW LRTISVILF LNKQDLLAE 
KVLAKIEDY FPEFARYTT PEDATPEPG EDPRVTRAK YFIRDEFLR 
ISTASGDGR HYCYPHFTC AVDTENIRR VFNDCRDII QRMHLRQYE 
LL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7KH0_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7KH0_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFREK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP30518
Sequence
>7KH0_Chain_R
RDPLLARAE LALLSIVFV AVALSNGLV LAALARRGR RGHWAPIHV 
FIGHLCLAD LAVALFQVL PQLAWKATD RFRGPDALC RAVKYLQMV 
GMYASSYMI LAMTLDRHR AICRPMLAY RNRPVLVAW AFSLLLSLP 
QLFIFAQRN VTDCWACFA EPWGRRTYV TWIALMVFV APTLGIAAC 
QVLIFREIH ASLVPGPSA AVAKTVRMT LVIVVVYVL CWAPFFLVQ 
LWAAWDPEA PLEGAPFVL LMLLASLNS CTNPWIYAS FSSSVSSEL 
RSLLCC


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9IV2B2AdhesionAdhesionADGRD1Homo sapiens5α-DHT-chim(NtGi1-Gs)/β1/γ23.532025-02-12doi.org/10.1016/j.cell.2025.01.006
9IV2 (No Gprot) B2AdhesionAdhesionADGRD1Homo sapiens5α-DHT-3.532025-02-12doi.org/10.1016/j.cell.2025.01.006
7R0CAPeptideVasopressin and OxytocinV2Homo sapiensAVP-Arrestin24.732022-09-1410.1126/sciadv.abo7761
7DW9APeptideVasopressin and OxytocinV2Homo sapiensAVP-chim(NtGi1-Gs)/β1/γ22.62021-07-2110.1038/s41422-021-00480-2
7DW9 (No Gprot) APeptideVasopressin and OxytocinV2Homo sapiensAVP-2.62021-07-2110.1038/s41422-021-00480-2
7BB7APeptideVasopressin and OxytocinV2Homo sapiensAVP-Gs/β1/γ24.42021-06-0210.1126/sciadv.abg5628
7BB7 (No Gprot) APeptideVasopressin and OxytocinV2Homo sapiensAVP-4.42021-06-0210.1126/sciadv.abg5628
7BB6APeptideVasopressin and OxytocinV2Homo sapiensAVP-Gs/β1/γ24.22021-06-0210.1126/sciadv.abg5628
7BB6 (No Gprot) APeptideVasopressin and OxytocinV2Homo sapiensAVP-4.22021-06-0210.1126/sciadv.abg5628
7KH0 (No Gprot) APeptideVasopressin and OxytocinV2Homo sapiensAVP-2.82021-05-2610.1038/s41422-021-00483-z
3V2YALipidLysophospholipidS1P1Homo sapiensPubChem 51892645--2.82012-02-1510.1126/science.1215904
3V2WALipidLysophospholipidS1P1Homo sapiensPubChem 51892645--3.352012-02-1510.1126/science.1215904




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