psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	A:A:L12	A:A:T11	4.42	No	No	0	2	4
2	A:A:D16	A:A:L12	8.14	No	No	0	4	2
3	A:A:K17	A:A:L12	2.82	No	No	0	3	2
4	A:A:D16	A:A:S13	5.89	No	No	0	4	7
5	A:A:K24	A:A:V20	3.04	No	No	0	4	3
6	A:A:V20	B:B:N88	2.96	No	Yes	0	3	7
7	A:A:R22	B:B:H91	3.39	No	Yes	0	5	5
8	A:A:S23	B:B:N88	4.47	No	Yes	0	7	7
9	A:A:K28	A:A:M25	4.32	No	No	0	4	4
10	A:A:I26	A:A:L30	2.85	No	No	5	9	5
11	A:A:I26	B:B:K89	5.82	No	Yes	5	9	9
12	A:A:E27	B:B:K89	8.1	No	Yes	0	6	9
13	A:A:K32	A:A:Q29	4.07	No	No	0	4	4
14	A:A:D33	A:A:Q29	6.53	No	No	0	5	4
15	A:A:L30	B:B:K89	2.82	No	Yes	5	5	9
16	A:A:K34	A:A:Q31	4.07	Yes	No	0	4	4
17	A:A:D33	B:B:K78	5.53	No	No	0	5	8
18	A:A:K34	B:B:L55	5.64	Yes	No	0	4	6
19	A:A:K34	R:R:Q61	5.42	Yes	No	20	4	6
20	A:A:K34	R:R:Q64	2.71	Yes	No	20	4	8
21	A:A:Q35	R:R:T144	2.83	No	No	0	3	9
22	A:A:R42	A:A:Y37	12.35	No	No	0	9	4
23	A:A:Y37	B:B:L55	3.52	No	No	0	4	6
24	A:A:R38	R:R:Q64	21.03	No	No	0	4	8
25	A:A:R38	R:R:P140	2.88	No	No	0	4	7
26	A:A:R42	A:A:T40	3.88	No	No	0	9	7
27	A:A:H220	A:A:T40	6.85	No	No	0	7	7
28	A:A:H41	A:A:V217	2.77	Yes	No	22	6	5
29	A:A:F219	A:A:H41	4.53	Yes	Yes	22	8	6
30	A:A:H41	A:A:T242	4.11	Yes	No	0	6	8
31	A:A:H41	R:R:L137	5.14	Yes	No	0	6	7
32	A:A:F222	A:A:R42	3.21	No	No	0	7	9
33	A:A:F219	A:A:L43	4.87	Yes	No	0	8	7
34	A:A:I245	A:A:L43	2.85	No	No	0	7	7
35	A:A:L44	A:A:L46	5.54	No	Yes	23	9	8
36	A:A:F238	A:A:L44	10.96	Yes	No	0	9	9
37	A:A:I244	A:A:L44	4.28	No	No	23	8	9
38	A:A:K53	A:A:L45	5.64	No	No	0	9	8
39	A:A:D223	A:A:L45	4.07	No	No	0	9	8
40	A:A:I245	A:A:L45	2.85	No	No	0	7	8
41	A:A:I244	A:A:L46	2.85	No	Yes	23	8	8
42	A:A:F246	A:A:L46	3.65	No	Yes	0	9	8
43	A:A:D249	A:A:N50	9.42	No	No	0	9	9
44	A:A:D252	A:A:N50	4.04	No	No	24	8	9
45	A:A:N50	A:A:R265	9.64	No	Yes	24	9	9
46	A:A:S51	A:A:V247	6.46	No	No	0	9	7
47	A:A:K58	A:A:S54	3.06	No	No	0	9	9
48	A:A:S366	A:A:T55	7.99	No	No	0	9	9
49	A:A:I56	A:A:N292	4.25	No	Yes	0	7	9
50	A:A:R61	A:A:V57	3.92	No	No	0	8	7
51	A:A:M60	A:A:Q59	8.16	No	No	0	9	9
52	A:A:N371	A:A:Q59	3.96	Yes	No	0	9	9
53	A:A:F212	A:A:M60	4.98	Yes	No	0	9	9
54	A:A:F208	A:A:S205	3.96	No	No	0	5	7
55	A:A:G206	B:B:N119	5.09	No	Yes	0	8	9
56	A:A:I207	A:A:V224	3.07	No	No	0	9	9
57	A:A:I207	B:B:W99	3.52	No	Yes	0	9	9
58	A:A:D223	A:A:F208	4.78	No	No	0	9	5
59	A:A:F208	A:A:G225	4.52	No	No	0	5	9
60	A:A:E209	A:A:K211	12.15	No	No	21	9	4
61	A:A:E209	A:A:H220	9.85	No	No	21	9	7
62	A:A:E209	A:A:F222	11.66	No	No	0	9	7
63	A:A:M221	A:A:T210	3.01	No	No	0	8	7
64	A:A:H220	A:A:K211	14.41	No	No	21	7	4
65	A:A:F212	A:A:F219	10.72	Yes	Yes	0	9	8
66	A:A:F212	A:A:M221	3.73	Yes	No	0	9	8
67	A:A:A372	A:A:F212	2.77	No	Yes	0	8	9
68	A:A:N218	A:A:Q213	7.92	No	No	0	4	3
69	A:A:D215	A:A:V214	2.92	No	No	13	5	6
70	A:A:R373	A:A:V214	3.92	No	No	13	5	6
71	A:A:F376	A:A:V214	5.24	No	No	13	8	6
72	A:A:D215	A:A:R373	10.72	No	No	13	5	5
73	A:A:D215	A:A:F376	4.78	No	No	13	5	8
74	A:A:F219	A:A:V217	5.24	Yes	No	22	8	5
75	A:A:C379	A:A:F219	2.79	No	Yes	0	8	8
76	A:A:I245	A:A:M221	2.92	No	No	0	7	8
77	A:A:F222	B:B:W99	10.02	No	Yes	0	7	9
78	A:A:Q227	A:A:V224	2.87	Yes	No	0	9	9
79	A:A:V224	A:A:W234	7.36	No	Yes	0	9	9
80	A:A:Q227	B:B:L117	3.99	Yes	No	4	9	9
81	A:A:Q227	B:B:N119	3.96	Yes	Yes	0	9	9
82	A:A:Q227	B:B:Y145	4.51	Yes	Yes	4	9	8
83	A:A:E230	A:A:R228	9.3	No	No	0	9	9
84	A:A:R228	B:B:T164	5.17	No	No	0	9	6
85	A:A:R231	A:A:W234	6	No	Yes	0	9	9
86	A:A:D272	A:A:R231	10.72	No	No	0	8	9
87	A:A:K233	B:B:D186	4.15	Yes	Yes	4	9	9
88	A:A:K233	B:B:M188	4.32	Yes	No	4	9	8
89	A:A:K233	B:B:C204	4.85	Yes	Yes	4	9	7
90	A:A:K233	B:B:D228	5.53	Yes	Yes	4	9	9
91	A:A:I235	A:A:W234	3.52	No	Yes	0	9	9
92	A:A:F238	A:A:W234	3.01	Yes	Yes	0	9	9
93	A:A:W234	B:B:Y145	4.82	Yes	Yes	0	9	8
94	A:A:Q236	A:A:W281	8.76	No	Yes	0	8	5
95	A:A:C237	A:A:F238	2.79	No	Yes	0	8	9
96	A:A:C237	B:B:Y59	2.69	No	Yes	2	8	8
97	A:A:C237	B:B:Q75	6.1	No	Yes	2	8	9
98	A:A:F238	A:A:V241	3.93	Yes	No	0	9	9
99	A:A:F238	B:B:W99	9.02	Yes	Yes	0	9	9
100	A:A:D240	A:A:N239	5.39	No	No	2	6	8
101	A:A:N239	B:B:K57	5.6	No	Yes	2	8	9
102	A:A:N239	B:B:W332	4.52	No	Yes	2	8	9
103	A:A:D240	B:B:K57	5.53	No	Yes	2	6	9
104	A:A:I285	A:A:V241	3.07	No	No	0	7	9
105	A:A:I244	A:A:I285	2.94	No	No	0	8	7
106	A:A:D272	A:A:F246	8.36	No	No	0	8	9
107	A:A:F246	A:A:L289	3.65	No	No	0	9	9
108	A:A:N292	A:A:V247	2.96	Yes	No	0	9	7
109	A:A:F345	A:A:V248	6.55	Yes	No	0	8	7
110	A:A:D249	A:A:S251	7.36	No	No	0	9	9
111	A:A:D249	A:A:K293	17.97	No	No	0	9	9
112	A:A:D252	A:A:S251	2.94	No	No	0	8	9
113	A:A:D252	A:A:R265	5.96	No	Yes	24	8	9
114	A:A:K300	A:A:Y253	15.53	No	No	0	9	8
115	A:A:I308	A:A:Y253	13.3	No	No	0	7	8
116	A:A:Y253	A:A:Y311	7.94	No	No	0	8	6
117	A:A:E268	A:A:R265	6.98	No	Yes	0	9	9
118	A:A:F312	A:A:L266	3.65	No	No	0	8	8
119	A:A:I341	A:A:L266	2.85	No	No	0	8	8
120	A:A:L270	A:A:Q267	5.32	Yes	No	0	6	4
121	A:A:N271	A:A:Q267	5.28	No	No	0	5	4
122	A:A:E344	A:A:L270	3.98	No	Yes	0	5	6
123	A:A:F345	A:A:L270	9.74	Yes	Yes	0	8	6
124	A:A:I348	A:A:L270	2.85	No	Yes	0	4	6
125	A:A:F273	A:A:F345	5.36	No	Yes	0	9	8
126	A:A:F273	A:A:I348	6.28	No	No	0	9	4
127	A:A:C359	A:A:F273	2.79	No	No	0	5	9
128	A:A:K274	A:A:N278	4.2	No	No	0	5	8
129	A:A:I348	A:A:K274	4.36	No	No	0	4	5
130	A:A:N278	A:A:W277	5.65	No	Yes	25	8	6
131	A:A:V287	A:A:W277	3.68	No	Yes	0	6	6
132	A:A:S349	A:A:W277	3.71	No	Yes	0	7	6
133	A:A:S352	A:A:W277	4.94	No	Yes	25	5	6
134	A:A:H357	A:A:W277	20.1	No	Yes	0	7	6
135	A:A:N278	A:A:S352	5.96	No	No	25	8	5
136	A:A:L282	A:A:N279	10.98	No	No	0	9	8
137	A:A:R280	A:A:W281	16.99	No	Yes	0	5	5
138	A:A:R280	A:A:R283	5.33	No	No	0	5	3
139	A:A:W281	B:B:D290	4.47	Yes	Yes	2	5	6
140	A:A:W281	B:B:R314	9	Yes	Yes	2	5	8
141	A:A:R283	A:A:R356	6.4	No	No	0	3	2
142	A:A:R356	A:A:T284	7.76	No	No	0	2	4
143	A:A:I382	A:A:S286	7.74	No	No	0	6	8
144	A:A:D378	A:A:I288	11.2	Yes	No	0	7	9
145	A:A:L289	A:A:L291	2.77	No	No	0	9	8
146	A:A:F345	A:A:L289	4.87	Yes	No	0	8	9
147	A:A:F290	A:A:H362	5.66	No	No	0	9	9
148	A:A:F290	A:A:T364	11.67	No	Yes	0	9	9
149	A:A:F363	A:A:L291	3.65	Yes	No	0	5	8
150	A:A:K293	A:A:N292	4.2	No	Yes	0	9	9
151	A:A:N292	A:A:T364	4.39	Yes	Yes	0	9	9
152	A:A:N292	A:A:S366	7.45	Yes	No	0	9	9
153	A:A:K338	A:A:Q294	2.71	No	No	26	5	6
154	A:A:F363	A:A:Q294	9.37	Yes	No	26	5	6
155	A:A:D295	A:A:L296	2.71	No	No	0	9	6
156	A:A:D295	A:A:E299	3.9	No	No	0	9	6
157	A:A:L297	A:A:V334	2.98	No	Yes	0	8	4
158	A:A:K300	A:A:S306	9.18	No	No	0	9	7
159	A:A:D331	A:A:L302	5.43	Yes	No	0	4	2
160	A:A:K305	A:A:S306	3.06	No	No	0	3	7
161	A:A:E309	A:A:K307	9.45	No	No	0	4	6
162	A:A:F315	A:A:I308	7.54	No	No	0	6	7
163	A:A:D310	A:A:Y311	6.9	No	No	0	3	6
164	A:A:E314	A:A:P313	6.29	No	No	0	6	6
165	A:A:E314	A:A:R317	5.82	No	No	0	6	2
166	A:A:F315	A:A:R336	12.83	No	No	0	6	5
167	A:A:F315	A:A:F340	13.93	No	No	0	6	7
168	A:A:P321	A:A:Y318	5.56	No	No	0	5	6
169	A:A:F340	A:A:Y318	5.16	No	No	0	7	6
170	A:A:D343	A:A:Y318	9.2	No	No	0	3	6
171	A:A:P321	A:A:T320	3.5	No	No	0	5	1
172	A:A:R336	A:A:T320	3.88	No	No	0	5	1
173	A:A:A324	A:A:Y339	6.67	No	Yes	0	3	3
174	A:A:P326	A:A:T335	8.74	No	No	0	1	4
175	A:A:E327	A:A:P328	14.15	No	No	0	4	1
176	A:A:D331	A:A:P332	3.22	Yes	No	0	4	1
177	A:A:D331	A:A:R333	10.72	Yes	No	0	4	5
178	A:A:K338	A:A:Y339	3.58	No	Yes	0	5	3
179	A:A:F363	A:A:K338	12.41	Yes	No	26	5	5
180	A:A:R342	A:A:Y339	7.2	Yes	Yes	0	4	3
181	A:A:E344	A:A:F340	4.66	No	No	0	5	7
182	A:A:P361	A:A:R342	5.76	No	Yes	0	5	4
183	A:A:F363	A:A:R342	3.21	Yes	Yes	0	5	4
184	A:A:D343	A:A:R347	3.57	No	No	0	3	4
185	A:A:E344	A:A:R347	10.47	No	No	0	5	4
186	A:A:S349	A:A:T350	3.2	No	No	0	7	4
187	A:A:C359	A:A:S349	3.44	No	No	0	5	7
188	A:A:G355	A:A:Y358	2.9	No	Yes	0	2	4
189	A:A:Y358	A:A:Y360	2.98	Yes	Yes	14	4	8
190	A:A:R385	A:A:Y358	9.26	Yes	Yes	14	5	4
191	A:A:R389	A:A:Y358	3.09	No	Yes	0	4	4
192	A:A:Y358	R:R:L226	5.86	Yes	Yes	14	4	5
193	A:A:D378	A:A:Y360	8.05	Yes	Yes	0	7	8
194	A:A:I382	A:A:Y360	4.84	No	Yes	0	6	8
195	A:A:R385	A:A:Y360	6.17	Yes	Yes	14	5	8
196	A:A:H362	A:A:R374	6.77	No	Yes	0	9	4
197	A:A:D378	A:A:H362	8.82	Yes	No	0	7	9
198	A:A:N371	A:A:T364	2.92	Yes	Yes	12	9	9
199	A:A:R374	A:A:T364	6.47	Yes	Yes	12	4	9
200	A:A:C365	A:A:D368	7.78	No	No	0	8	9
201	A:A:D368	A:A:N371	4.04	No	Yes	12	9	9
202	A:A:D368	A:A:R374	4.76	No	Yes	12	9	4
203	A:A:E370	A:A:R373	6.98	No	No	0	4	5
204	A:A:N371	A:A:R374	3.62	Yes	Yes	12	9	4
205	A:A:F376	R:R:L137	4.87	No	No	0	8	7
206	A:A:Q384	A:A:R380	3.5	Yes	No	27	6	7
207	A:A:R380	R:R:P136	7.21	No	No	27	7	9
208	A:A:I383	R:R:P136	3.39	No	No	0	8	9
209	A:A:Q384	R:R:P136	4.74	Yes	No	27	6	9
210	A:A:Q384	R:R:Q222	5.12	Yes	No	0	6	8
211	A:A:R385	R:R:Q222	11.68	Yes	No	0	5	8
212	A:A:R385	R:R:L226	6.07	Yes	Yes	14	5	5
213	A:A:L388	A:A:L393	2.77	No	Yes	0	8	8
214	A:A:L388	R:R:I133	4.28	No	No	0	8	8
215	A:A:L394	A:A:R389	4.86	No	No	0	8	4
216	A:A:Q390	R:R:K459	5.42	No	No	0	4	4
217	A:A:Q390	R:R:T460	4.25	No	No	0	4	8
218	A:A:Y391	R:R:R129	12.35	No	Yes	0	4	9
219	A:A:Y391	R:R:H458	7.62	No	Yes	0	4	9
220	A:A:E392	R:R:M457	2.71	No	No	0	6	9
221	A:A:E392	R:R:K462	4.05	No	No	0	6	9
222	A:A:L393	R:R:V215	2.98	Yes	No	0	8	9
223	A:A:L393	R:R:A397	3.15	Yes	No	0	8	8
224	A:A:L393	R:R:I401	2.85	Yes	No	0	8	9
225	A:A:L394	R:R:L226	4.15	No	Yes	0	8	5
226	B:B:L7	B:B:Q6	6.65	Yes	No	0	8	1
227	B:B:L7	G:G:A12	3.15	Yes	No	0	8	5
228	B:B:Q9	B:B:R8	4.67	No	No	0	3	3
229	B:B:E10	G:G:K20	2.7	No	No	0	8	6
230	B:B:L14	G:G:L19	2.77	No	Yes	0	8	9
231	B:B:L14	G:G:K20	8.46	No	No	0	8	6
232	B:B:K15	G:G:L19	2.82	No	Yes	0	6	9
233	B:B:N16	B:B:R19	13.26	No	No	0	1	4
234	B:B:I18	B:B:R22	5.01	No	No	0	7	6
235	B:B:I18	G:G:A23	3.25	No	No	0	7	8
236	B:B:A21	G:G:R27	2.77	No	Yes	0	4	8
237	B:B:D258	B:B:R22	7.15	Yes	No	0	7	6
238	B:B:R22	G:G:R27	3.2	No	Yes	0	6	8
239	B:B:A26	B:B:Q259	4.55	No	No	0	3	6
240	B:B:A28	B:B:D27	3.09	No	No	0	4	8
241	B:B:D27	G:G:K29	11.06	No	No	0	8	4
242	B:B:D27	G:G:S31	8.83	No	No	0	8	9
243	B:B:Q32	B:B:T29	9.92	No	No	0	1	3
244	B:B:L30	B:B:T34	4.42	Yes	No	0	5	5
245	B:B:L261	B:B:L30	4.15	No	Yes	0	5	5
246	B:B:L30	B:B:M262	4.24	Yes	Yes	0	5	4
247	B:B:L30	G:G:A34	4.73	Yes	No	0	5	6
248	B:B:M262	B:B:S31	3.07	Yes	No	0	4	1
249	B:B:I37	B:B:T34	3.04	No	No	0	2	5
250	B:B:L300	B:B:T34	4.42	Yes	No	0	6	5
251	B:B:N35	B:B:N36	2.72	No	No	0	1	1
252	B:B:I37	G:G:M38	2.92	No	No	0	2	4
253	B:B:D38	B:B:P39	4.83	No	No	0	1	1
254	B:B:R283	B:B:V40	7.85	No	Yes	15	9	3
255	B:B:D298	B:B:V40	7.3	Yes	Yes	15	9	3
256	B:B:V40	G:G:L51	2.98	Yes	Yes	0	3	6
257	B:B:I43	B:B:M45	2.92	No	No	0	3	4
258	B:B:M45	B:B:W339	3.49	No	Yes	0	4	9
259	B:B:M45	G:G:L50	2.83	No	No	0	4	9
260	B:B:R46	B:B:R48	7.46	No	No	0	5	7
261	B:B:T47	B:B:W339	7.28	No	Yes	0	3	9
262	B:B:N340	B:B:R48	9.64	No	No	0	9	7
263	B:B:I338	B:B:R49	5.01	No	No	0	5	7
264	B:B:R52	B:B:T50	3.88	No	No	0	7	3
265	B:B:K337	B:B:T50	4.5	Yes	No	0	6	3
266	B:B:L51	B:B:W82	9.11	No	Yes	5	9	9
267	B:B:L336	B:B:L51	5.54	Yes	No	5	7	9
268	B:B:F335	B:B:R52	8.55	No	No	0	4	7
269	B:B:H54	B:B:I58	5.3	Yes	No	0	9	9
270	B:B:H54	B:B:S72	6.97	Yes	No	5	9	9
271	B:B:H54	B:B:S74	12.55	Yes	No	0	9	9
272	B:B:H54	B:B:I80	10.61	Yes	No	5	9	8
273	B:B:H54	B:B:W82	3.17	Yes	Yes	5	9	9
274	B:B:D76	B:B:L55	14.93	Yes	No	0	9	6
275	B:B:K57	B:B:Y59	4.78	Yes	Yes	2	9	8
276	B:B:K57	B:B:Q75	6.78	Yes	Yes	2	9	9
277	B:B:K57	B:B:W332	13.92	Yes	Yes	2	9	9
278	B:B:I58	B:B:L336	2.85	No	Yes	0	9	7
279	B:B:Q75	B:B:Y59	11.27	Yes	Yes	2	9	8
280	B:B:M101	B:B:Y59	3.59	No	Yes	0	9	8
281	B:B:W332	B:B:Y59	3.86	Yes	Yes	2	9	8
282	B:B:C317	B:B:M61	4.86	No	No	0	7	6
283	B:B:A328	B:B:M61	3.22	No	No	0	5	6
284	B:B:H62	B:B:R150	12.41	No	No	0	6	6
285	B:B:L70	B:B:W63	6.83	No	Yes	0	5	7
286	B:B:S84	B:B:W63	6.18	No	Yes	0	5	7
287	B:B:T321	B:B:W63	3.64	No	Yes	0	7	7
288	B:B:A328	B:B:W63	3.89	No	Yes	0	5	7
289	B:B:G64	B:B:Y105	4.35	No	Yes	0	5	6
290	B:B:D66	B:B:R68	3.57	No	No	0	8	5
291	B:B:D66	B:B:L69	5.43	No	No	0	8	5
292	B:B:S67	B:B:T321	4.8	No	No	30	5	7
293	B:B:D323	B:B:S67	4.42	No	No	30	7	5
294	B:B:D83	B:B:R68	14.29	No	No	0	8	5
295	B:B:R68	B:B:Y85	21.61	No	No	0	5	4
296	B:B:D83	B:B:L69	4.07	No	No	0	8	5
297	B:B:L70	B:B:W82	4.56	No	Yes	0	5	9
298	B:B:I81	B:B:V71	3.07	No	No	0	7	8
299	B:B:S72	B:B:W82	6.18	No	Yes	5	9	9
300	B:B:L336	B:B:S72	3	Yes	No	5	7	9
301	B:B:A73	B:B:V100	3.39	No	No	0	9	9
302	B:B:A73	B:B:C103	3.61	No	No	0	9	8
303	B:B:D76	B:B:S74	7.36	Yes	No	0	9	9
304	B:B:Q75	B:B:W99	5.48	Yes	Yes	0	9	9
305	B:B:D76	B:B:G77	3.35	Yes	No	0	9	8
306	B:B:D76	B:B:K78	6.91	Yes	No	0	9	8
307	B:B:K78	B:B:P94	3.35	No	No	0	8	5
308	B:B:I93	B:B:L79	4.28	No	No	0	7	7
309	B:B:L79	B:B:L95	2.77	No	Yes	16	7	8
310	B:B:C114	B:B:L79	3.17	No	No	16	8	7
311	B:B:I80	B:B:W82	15.27	No	Yes	5	8	9
312	B:B:H91	B:B:I81	5.3	Yes	No	0	5	7
313	B:B:I81	B:B:L126	2.85	No	No	0	7	5
314	B:B:K89	B:B:W82	9.28	Yes	Yes	5	9	9
315	B:B:L336	B:B:W82	3.42	Yes	Yes	5	7	9
316	B:B:D83	B:B:T86	7.23	No	No	0	8	6
317	B:B:I338	B:B:S84	3.1	No	No	0	5	5
318	B:B:S84	G:G:F61	3.96	No	Yes	0	5	8
319	B:B:Y85	G:G:P60	12.52	No	No	31	4	9
320	B:B:Y85	G:G:F61	6.19	No	Yes	31	4	8
321	B:B:N88	B:B:T86	7.31	Yes	No	0	7	6
322	B:B:H91	B:B:V90	5.54	Yes	No	0	5	5
323	B:B:H91	B:B:V133	5.54	Yes	No	0	5	4
324	B:B:I93	B:B:P94	3.39	No	No	0	7	5
325	B:B:I93	B:B:V133	4.61	No	No	0	7	4
326	B:B:L95	B:B:V100	4.47	Yes	No	0	8	9
327	B:B:C114	B:B:L95	3.17	No	Yes	16	8	8
328	B:B:L95	B:B:Y124	5.86	Yes	Yes	16	8	6
329	B:B:E138	B:B:R96	4.65	No	No	0	6	6
330	B:B:D118	B:B:S97	8.83	No	No	0	9	8
331	B:B:L117	B:B:W99	5.69	No	Yes	0	9	9
332	B:B:G116	B:B:M101	3.49	No	No	0	9	9
333	B:B:M101	B:B:Y145	3.59	No	Yes	0	9	8
334	B:B:C149	B:B:T102	3.38	No	No	0	8	8
335	B:B:G109	B:B:Y105	4.35	No	Yes	0	5	6
336	B:B:F151	B:B:P107	2.89	No	No	0	9	6
337	B:B:N110	B:B:S108	7.45	No	No	32	4	6
338	B:B:D154	B:B:S108	8.83	No	No	32	6	6
339	B:B:K127	B:B:N110	9.79	No	No	0	4	4
340	B:B:D154	B:B:N110	4.04	No	No	32	6	4
341	B:B:I123	B:B:Y111	3.63	Yes	No	0	6	4
342	B:B:N125	B:B:Y111	12.79	No	No	0	4	4
343	B:B:D154	B:B:Y111	3.45	No	No	0	6	4
344	B:B:L126	B:B:V112	2.98	No	No	0	5	8
345	B:B:C114	B:B:Y124	5.38	No	Yes	16	8	6
346	B:B:L117	B:B:Y145	3.52	No	Yes	4	9	8
347	B:B:D118	B:B:I120	8.4	No	No	0	9	6
348	B:B:G144	B:B:N119	5.09	No	Yes	0	8	9
349	B:B:E138	B:B:I120	5.47	No	No	0	6	6
350	B:B:C121	B:B:L139	3.17	No	Yes	0	8	9
351	B:B:S122	B:B:Y124	5.09	No	Yes	0	8	6
352	B:B:E138	B:B:S122	4.31	No	No	0	6	8
353	B:B:I123	B:B:S136	3.1	Yes	No	0	6	4
354	B:B:I123	B:B:R137	3.76	Yes	No	33	6	5
355	B:B:I123	B:B:L139	4.28	Yes	Yes	0	6	9
356	B:B:I123	B:B:I171	4.42	Yes	No	33	6	6
357	B:B:V135	B:B:Y124	5.05	No	Yes	0	4	6
358	B:B:N125	B:B:T128	5.85	No	Yes	0	4	3
359	B:B:L126	B:B:V133	2.98	No	No	0	5	4
360	B:B:E130	B:B:T128	4.23	No	Yes	17	3	3
361	B:B:N132	B:B:T128	2.92	No	Yes	17	3	3
362	B:B:R134	B:B:T128	6.47	No	Yes	17	3	3
363	B:B:E130	B:B:N132	5.26	No	No	17	3	3
364	B:B:E130	B:B:R134	6.98	No	No	17	3	3
365	B:B:I171	B:B:R137	3.76	No	No	33	6	5
366	B:B:L139	B:B:W169	11.39	Yes	Yes	0	9	8
367	B:B:H142	B:B:L146	5.14	Yes	No	6	9	7
368	B:B:H142	B:B:T159	5.48	Yes	No	6	9	9
369	B:B:H142	B:B:S161	13.95	Yes	No	6	9	9
370	B:B:D163	B:B:H142	5.04	Yes	Yes	6	9	9
371	B:B:H142	B:B:T165	2.74	Yes	No	6	9	7
372	B:B:A167	B:B:H142	2.93	No	Yes	6	4	9
373	B:B:H142	B:B:W169	4.23	Yes	Yes	6	9	8
374	B:B:D163	B:B:T143	5.78	Yes	No	0	9	5
375	B:B:G162	B:B:Y145	5.79	No	Yes	0	9	8
376	B:B:D186	B:B:Y145	6.9	Yes	Yes	4	9	8
377	B:B:L146	B:B:T159	4.42	No	No	6	7	9
378	B:B:S147	B:B:S160	3.26	No	No	0	9	6
379	B:B:C148	B:B:R150	2.79	No	No	0	6	6
380	B:B:C148	B:B:L190	3.17	No	No	0	6	5
381	B:B:F151	B:B:I171	3.77	No	No	0	9	6
382	B:B:D153	B:B:L152	6.79	No	No	0	5	3
383	B:B:L152	B:B:L192	4.15	No	No	0	3	5
384	B:B:L152	B:B:T196	4.42	No	No	0	3	1
385	B:B:D153	B:B:Q156	13.05	No	No	0	5	5
386	B:B:D170	B:B:N155	4.04	No	No	0	9	3
387	B:B:E172	B:B:N155	5.26	No	No	0	6	3
388	B:B:I157	B:B:W169	3.52	No	Yes	0	7	8
389	B:B:L190	B:B:V158	2.98	No	No	3	5	5
390	B:B:F199	B:B:V158	3.93	Yes	No	3	9	5
391	B:B:T159	B:B:W169	8.49	No	Yes	6	9	8
392	B:B:S160	B:B:V187	6.46	No	No	0	6	9
393	B:B:G162	B:B:S161	3.71	No	No	0	9	9
394	B:B:D163	B:B:S161	8.83	Yes	No	6	9	9
395	B:B:D163	B:B:T165	11.56	Yes	No	6	9	7
396	B:B:T165	B:B:T181	3.14	No	No	0	7	2
397	B:B:C166	B:B:F180	4.19	No	Yes	0	8	7
398	B:B:A167	B:B:W169	3.89	No	Yes	6	4	8
399	B:B:A167	B:B:Q176	4.55	No	No	6	4	4
400	B:B:L168	B:B:T177	4.42	No	No	3	6	4
401	B:B:L168	B:B:T178	5.9	No	No	3	6	4
402	B:B:Q176	B:B:W169	12.05	No	Yes	6	4	8
403	B:B:D170	B:B:T173	5.78	No	No	0	9	5
404	B:B:D170	B:B:T177	4.34	No	No	0	9	4
405	B:B:E172	B:B:T173	2.82	No	No	0	6	5
406	B:B:Q176	B:B:T179	8.5	No	No	0	4	4
407	B:B:T177	B:B:T178	4.71	No	No	3	4	4
408	B:B:F180	B:B:T178	6.49	Yes	No	3	7	4
409	B:B:F180	B:B:F199	9.65	Yes	Yes	3	7	9
410	B:B:F180	B:B:W211	14.03	Yes	Yes	3	7	8
411	B:B:F180	B:B:G216	3.01	Yes	No	0	7	4
412	B:B:G182	B:B:T181	3.64	No	No	0	6	2
413	B:B:H183	B:B:V187	4.15	Yes	No	3	9	9
414	B:B:H183	B:B:S201	5.58	Yes	Yes	3	9	9
415	B:B:A203	B:B:H183	8.78	No	Yes	0	8	9
416	B:B:H183	B:B:S207	2.79	Yes	No	0	9	5
417	B:B:H183	B:B:K209	14.41	Yes	Yes	3	9	6
418	B:B:G185	B:B:T184	3.64	No	No	0	5	3
419	B:B:D205	B:B:T184	2.89	No	No	0	9	3
420	B:B:D186	B:B:M188	4.16	Yes	No	4	9	8
421	B:B:C204	B:B:D186	6.22	Yes	Yes	4	7	9
422	B:B:S201	B:B:V187	3.23	Yes	No	3	9	9
423	B:B:C204	B:B:M188	3.24	Yes	No	4	7	8
424	B:B:I232	B:B:S189	3.1	Yes	No	0	8	7
425	B:B:F199	B:B:L190	3.65	Yes	No	3	9	5
426	B:B:S191	B:B:V200	4.85	No	Yes	1	8	6
427	B:B:I232	B:B:S191	3.1	Yes	No	1	8	8
428	B:B:F234	B:B:S191	3.96	Yes	No	1	5	8
429	B:B:A193	B:B:D195	3.09	No	No	0	4	5
430	B:B:A193	B:B:L198	3.15	No	Yes	0	4	3
431	B:B:A193	B:B:F234	4.16	No	Yes	0	4	5
432	B:B:D195	B:B:P194	3.22	No	No	0	5	4
433	B:B:G238	B:B:P194	4.06	No	No	0	7	4
434	B:B:D195	B:B:R197	15.48	No	No	0	5	5
435	B:B:L198	B:B:R197	4.86	Yes	No	0	3	5
436	B:B:R197	B:B:R214	3.2	No	No	0	5	9
437	B:B:L198	B:B:L210	5.54	Yes	No	0	3	5
438	B:B:D212	B:B:L198	2.71	No	Yes	0	9	3
439	B:B:F199	B:B:W211	15.03	Yes	Yes	3	9	8
440	B:B:L210	B:B:V200	2.98	No	Yes	0	5	6
441	B:B:I232	B:B:V200	3.07	Yes	Yes	1	8	6
442	B:B:F234	B:B:V200	5.24	Yes	Yes	1	5	6
443	B:B:G202	B:B:S201	3.71	No	Yes	0	6	9
444	B:B:S201	B:B:W211	7.41	Yes	Yes	3	9	8
445	B:B:A203	B:B:D205	3.09	No	No	0	8	9
446	B:B:C204	B:B:D228	6.22	Yes	Yes	4	7	9
447	B:B:D205	B:B:S207	7.36	No	No	0	9	5
448	B:B:A208	B:B:F241	2.77	No	Yes	0	6	6
449	B:B:K209	B:B:W211	5.8	Yes	Yes	3	6	8
450	B:B:C218	B:B:K209	4.85	No	Yes	3	5	6
451	B:B:K209	B:B:T221	12.01	Yes	No	0	6	7
452	B:B:L210	B:B:R219	7.29	No	No	0	5	5
453	B:B:C218	B:B:W211	5.22	No	Yes	3	5	8
454	B:B:D212	B:B:E215	7.8	No	No	0	9	3
455	B:B:D212	B:B:R219	11.91	No	No	0	9	5
456	B:B:E215	B:B:M217	6.77	No	No	0	3	3
457	B:B:M217	B:B:R219	4.96	No	No	0	3	5
458	B:B:C218	G:G:Q18	4.58	No	No	0	5	9
459	B:B:F222	B:B:Q220	7.03	Yes	No	1	8	7
460	B:B:D258	B:B:Q220	13.05	Yes	No	1	7	7
461	B:B:Q220	G:G:I25	5.49	No	No	1	7	2
462	B:B:T221	G:G:E22	8.47	No	No	0	7	9
463	B:B:F222	B:B:F241	8.57	Yes	Yes	1	8	6
464	B:B:F222	B:B:F253	6.43	Yes	Yes	1	8	6
465	B:B:D258	B:B:F222	4.78	Yes	Yes	1	7	8
466	B:B:H225	B:B:I229	3.98	Yes	No	1	9	7
467	B:B:H225	B:B:T243	5.48	Yes	Yes	1	9	8
468	B:B:H225	B:B:S245	12.55	Yes	No	1	9	9
469	B:B:D247	B:B:H225	7.56	Yes	Yes	1	9	9
470	B:B:H225	B:B:T249	2.74	Yes	Yes	1	9	6
471	B:B:H225	B:B:R251	12.41	Yes	Yes	1	9	8
472	B:B:D228	B:B:S227	4.42	Yes	No	4	9	6
473	B:B:D246	B:B:S227	2.94	No	No	4	9	6
474	B:B:D228	B:B:D246	9.31	Yes	No	4	9	9
475	B:B:I229	B:B:T243	3.04	No	Yes	1	7	8
476	B:B:D246	B:B:N230	8.08	No	No	0	9	9
477	B:B:A231	B:B:V276	3.39	No	No	0	5	6
478	B:B:F241	B:B:I232	3.77	Yes	Yes	1	6	8
479	B:B:I232	B:B:T243	4.56	Yes	Yes	1	8	8
480	B:B:F235	B:B:P236	7.22	Yes	Yes	7	6	7
481	B:B:F235	B:B:N237	7.25	Yes	No	7	6	5
482	B:B:F235	B:B:F278	6.43	Yes	Yes	7	6	7
483	B:B:F235	B:B:G282	4.52	Yes	No	7	6	9
484	B:B:F235	G:G:L37	3.65	Yes	No	0	6	7
485	B:B:F235	G:G:Y40	4.13	Yes	Yes	7	6	6
486	B:B:F235	G:G:C41	2.79	Yes	No	0	6	7
487	B:B:F278	B:B:P236	2.89	Yes	Yes	7	7	7
488	B:B:G282	B:B:P236	4.06	No	Yes	7	9	7
489	B:B:P236	G:G:Y40	4.17	Yes	Yes	7	7	6
490	B:B:N237	B:B:N239	12.26	No	No	0	5	2
491	B:B:N237	G:G:Y40	8.14	No	Yes	7	5	6
492	B:B:N239	B:B:R256	12.05	No	No	0	2	9
493	B:B:F241	B:B:F253	10.72	Yes	Yes	1	6	6
494	B:B:A242	B:B:F278	2.77	No	Yes	0	4	7
495	B:B:G244	B:B:T243	3.64	No	Yes	0	5	8
496	B:B:F253	B:B:T243	3.89	Yes	Yes	1	6	8
497	B:B:G244	B:B:I273	3.53	No	No	0	5	6
498	B:B:D247	B:B:S245	10.31	Yes	No	1	9	9
499	B:B:D247	B:B:T249	5.78	Yes	Yes	1	9	6
500	B:B:R251	B:B:T249	5.17	Yes	Yes	1	8	6
501	B:B:S265	B:B:T249	4.8	No	Yes	0	2	6
502	B:B:C250	B:B:Y264	4.03	No	Yes	0	8	5
503	B:B:C250	B:B:I273	4.91	No	No	0	8	6
504	B:B:F253	B:B:R251	3.21	Yes	Yes	1	6	8
505	B:B:E260	B:B:R251	12.79	No	Yes	1	6	8
506	B:B:R251	B:B:T263	10.35	Yes	No	1	8	1
507	B:B:L252	B:B:L261	5.54	No	No	0	7	5
508	B:B:L252	B:B:Y264	3.52	No	Yes	0	7	5
509	B:B:E260	B:B:F253	4.66	No	Yes	1	6	6
510	B:B:A257	B:B:D254	4.63	No	Yes	0	7	9
511	B:B:D254	B:B:L261	13.57	Yes	No	0	9	5
512	B:B:R256	G:G:I28	6.26	No	No	0	9	4
513	B:B:R256	G:G:D36	4.76	No	No	0	9	5
514	B:B:D258	G:G:I25	4.2	Yes	No	1	7	2
515	B:B:Q259	G:G:V30	2.87	No	No	0	6	8
516	B:B:E260	B:B:T263	4.23	No	No	1	6	1
517	B:B:M262	B:B:Y264	9.58	Yes	Yes	0	4	5
518	B:B:A302	B:B:M262	4.83	No	Yes	0	2	4
519	B:B:L285	B:B:Y264	4.69	No	Yes	0	6	5
520	B:B:W297	B:B:Y264	5.79	No	Yes	0	8	5
521	B:B:H266	B:B:N268	8.93	No	No	0	4	4
522	B:B:H266	B:B:R304	16.93	No	No	0	4	5
523	B:B:I269	B:B:Y289	3.63	No	Yes	0	4	7
524	B:B:C271	B:B:Y289	4.03	Yes	Yes	2	5	7
525	B:B:C271	B:B:D290	3.11	Yes	Yes	2	5	6
526	B:B:C271	B:B:D291	6.22	Yes	No	2	5	8
527	B:B:I273	B:B:Y289	10.88	No	Yes	0	6	7
528	B:B:S275	B:B:T274	3.2	No	No	0	8	8
529	B:B:D290	B:B:T274	2.89	Yes	No	2	6	8
530	B:B:R314	B:B:T274	3.88	Yes	No	2	8	8
531	B:B:L318	B:B:S275	3	No	No	0	6	8
532	B:B:L318	B:B:S277	3	No	No	0	6	5
533	B:B:S277	B:B:V320	4.85	No	No	0	5	7
534	B:B:F278	B:B:L285	4.87	Yes	No	0	7	6
535	B:B:S279	G:G:D48	4.42	No	No	0	9	9
536	B:B:G324	B:B:K280	3.49	No	No	0	9	1
537	B:B:S281	G:G:D48	10.31	No	No	0	9	9
538	B:B:D298	B:B:R283	11.91	Yes	No	15	9	9
539	B:B:L300	B:B:R283	13.36	Yes	No	15	6	9
540	B:B:L284	B:B:V296	4.47	No	No	0	5	5
541	B:B:L284	G:G:L51	4.15	No	Yes	0	5	6
542	B:B:L286	B:B:V296	5.96	No	No	0	7	5
543	B:B:L286	B:B:L318	2.77	No	No	0	7	6
544	B:B:A287	B:B:Y289	4	No	Yes	0	6	7
545	B:B:D291	B:B:Y289	3.45	No	Yes	2	8	7
546	B:B:N295	B:B:Y289	5.81	No	Yes	2	6	7
547	B:B:W297	B:B:Y289	2.89	No	Yes	2	8	7
548	B:B:D290	B:B:R314	8.34	Yes	Yes	2	6	8
549	B:B:D291	B:B:N293	4.04	No	No	0	8	5
550	B:B:N293	B:B:V307	2.96	No	No	0	5	3
551	B:B:C294	B:B:L308	9.52	No	No	0	5	7
552	B:B:N295	B:B:W297	5.65	No	No	2	6	8
553	B:B:N295	B:B:R304	7.23	No	No	0	6	5
554	B:B:D298	B:B:L300	2.71	Yes	Yes	15	9	6
555	B:B:D298	B:B:K301	5.53	Yes	No	0	9	5
556	B:B:L300	G:G:C41	6.35	Yes	No	0	6	7
557	B:B:L308	B:B:W339	20.5	No	Yes	0	7	9
558	B:B:G310	B:B:K337	3.49	No	Yes	0	5	6
559	B:B:H311	B:B:V315	4.15	Yes	No	9	9	7
560	B:B:H311	B:B:T329	5.48	Yes	No	9	9	8
561	B:B:H311	B:B:S331	16.74	Yes	No	9	9	9
562	B:B:D333	B:B:H311	5.04	No	Yes	9	9	9
563	B:B:H311	B:B:K337	6.55	Yes	Yes	0	9	6
564	B:B:D312	R:R:K59	5.53	No	No	0	5	7
565	B:B:N313	B:B:W332	5.65	No	Yes	0	7	9
566	B:B:R314	B:B:W332	12	Yes	Yes	2	8	9
567	B:B:T329	B:B:V315	3.17	No	No	9	8	7
568	B:B:S331	B:B:V315	3.23	No	No	9	9	7
569	B:B:S316	B:B:W332	4.94	No	Yes	0	9	9
570	B:B:V320	B:B:V327	3.21	No	No	0	7	6
571	B:B:D323	B:B:T321	4.34	No	No	30	7	7
572	B:B:D323	B:B:M325	8.32	No	No	0	7	5
573	B:B:M325	G:G:P49	6.71	No	No	0	5	7
574	B:B:A326	G:G:F61	4.16	No	Yes	0	7	8
575	B:B:V327	B:B:W339	3.68	No	Yes	0	6	9
576	B:B:T329	B:B:W339	4.85	No	Yes	0	8	9
577	B:B:D333	B:B:S331	7.36	No	No	9	9	9
578	B:B:D333	B:B:F335	5.97	No	No	0	9	4
579	B:B:K337	B:B:W339	6.96	Yes	Yes	0	6	9
580	B:B:N340	G:G:N59	4.09	No	No	0	9	9
581	B:B:N340	G:G:F61	6.04	No	Yes	0	9	8
582	G:G:N5	G:G:T6	4.39	No	No	0	4	3
583	G:G:I9	G:G:T6	7.6	No	No	0	2	3
584	G:G:M21	G:G:Q18	4.08	No	No	0	1	9
585	G:G:E22	G:G:Q18	7.65	No	No	0	9	9
586	G:G:I25	G:G:R27	8.77	No	Yes	0	2	8
587	G:G:I28	G:G:K32	5.82	No	No	0	4	5
588	G:G:H44	G:G:Y40	8.71	No	Yes	0	6	6
589	G:G:A43	G:G:H44	2.93	No	No	0	4	6
590	G:G:E47	G:G:H44	7.39	No	No	0	3	6
591	G:G:D48	G:G:L51	10.86	No	Yes	0	9	6
592	G:G:P49	G:G:V54	3.53	No	No	0	7	6
593	G:G:L51	G:G:T52	4.42	Yes	No	0	6	4
594	G:G:P55	G:G:V54	5.3	No	No	0	5	6
595	G:G:N59	G:G:V54	4.43	No	No	0	9	6
596	G:G:E58	G:G:P55	6.29	No	No	0	5	5
597	G:G:E58	G:G:S57	7.19	No	No	0	5	6
598	G:G:F61	G:G:P60	5.78	Yes	No	31	8	9
599	R:R:L28	R:R:P94	6.57	Yes	Yes	10	6	6
600	R:R:L28	R:R:W97	3.42	Yes	Yes	10	6	9
601	R:R:H30	R:R:T437	5.48	No	No	0	5	6
602	R:R:L181	R:R:R34	6.07	No	No	0	4	5
603	R:R:R34	R:R:T437	6.47	No	No	11	5	6
604	R:R:R34	R:R:W441	4	No	Yes	11	5	8
605	R:R:S35	R:R:S92	6.52	No	No	0	6	6
606	R:R:V37	R:R:W441	9.81	Yes	Yes	11	6	8
607	R:R:V37	W:W:?1	3.73	Yes	No	11	6	0
608	R:R:F444	R:R:L38	4.87	No	No	0	8	6
609	R:R:F41	R:R:L445	6.09	No	No	0	7	7
610	R:R:L42	R:R:S45	3	No	No	34	8	9
611	R:R:I81	R:R:L42	7.14	No	No	34	8	8
612	R:R:I81	R:R:S45	4.64	No	No	34	8	9
613	R:R:C448	R:R:S45	5.16	No	No	0	8	9
614	R:R:F46	R:R:L78	4.87	No	No	0	7	8
615	R:R:L74	R:R:N49	2.75	No	Yes	0	9	9
616	R:R:D77	R:R:N49	2.69	Yes	Yes	0	9	9
617	R:R:L78	R:R:N49	5.49	No	Yes	0	8	9
618	R:R:N49	R:R:P451	8.15	Yes	No	0	9	9
619	R:R:L52	R:R:L74	5.54	No	No	0	9	9
620	R:R:A53	R:R:L74	4.73	No	No	0	7	9
621	R:R:I465	R:R:V55	6.14	Yes	No	0	8	9
622	R:R:M468	R:R:V55	3.04	No	No	0	7	9
623	R:R:L56	R:R:N67	6.87	Yes	No	0	8	9
624	R:R:I70	R:R:L56	2.85	No	Yes	0	8	8
625	R:R:F71	R:R:L56	3.65	No	Yes	0	8	8
626	R:R:I461	R:R:L56	2.85	Yes	Yes	0	8	8
627	R:R:P60	R:R:Q57	3.16	No	No	0	8	4
628	R:R:F71	R:R:Q57	3.51	No	No	0	8	4
629	R:R:E464	R:R:K59	13.5	No	No	0	9	7
630	R:R:Q61	R:R:Q64	5.12	No	No	20	6	8
631	R:R:L62	R:R:L63	2.77	No	Yes	0	9	8
632	R:R:E464	R:R:L62	5.3	No	No	0	9	9
633	R:R:L63	R:R:T66	4.42	Yes	No	0	8	8
634	R:R:L63	R:R:N67	5.49	Yes	No	0	8	9
635	R:R:H458	R:R:L63	3.86	Yes	Yes	28	9	8
636	R:R:I461	R:R:L63	2.85	Yes	Yes	28	8	8
637	R:R:Q145	R:R:V65	4.3	No	No	0	4	7
638	R:R:D128	R:R:T66	4.34	No	No	0	9	8
639	R:R:N67	R:R:R68	4.82	No	No	0	9	7
640	R:R:R68	R:R:Y149	4.12	No	No	0	7	4
641	R:R:F69	R:R:V124	7.87	Yes	No	0	8	8
642	R:R:F71	R:R:V75	3.93	No	No	0	8	7
643	R:R:N72	R:R:T121	7.31	No	No	0	9	9
644	R:R:L152	R:R:N72	6.87	No	No	0	9	9
645	R:R:N72	R:R:W156	9.04	No	No	0	9	9
646	R:R:L73	R:R:T121	2.95	Yes	No	0	9	9
647	R:R:I122	R:R:L73	2.85	No	Yes	8	8	9
648	R:R:H450	R:R:L73	5.14	Yes	Yes	8	9	9
649	R:R:L73	R:R:Y454	4.69	Yes	Yes	8	9	9
650	R:R:D77	R:R:T76	4.34	Yes	No	0	9	9
651	R:R:C447	R:R:D77	3.11	No	Yes	0	9	9
652	R:R:D77	R:R:H450	6.3	Yes	Yes	0	9	9
653	R:R:F114	R:R:L79	6.09	Yes	No	0	6	7
654	R:R:Q80	R:R:T111	2.83	No	No	0	8	9
655	R:R:F114	R:R:Q80	9.37	Yes	No	0	6	8
656	R:R:C447	R:R:Q80	3.05	No	No	0	9	8
657	R:R:C447	R:R:I81	6.55	No	No	0	9	8
658	R:R:L83	R:R:S82	6.01	No	No	0	6	5
659	R:R:T111	R:R:V84	4.76	No	No	0	9	9
660	R:R:P94	R:R:V93	3.53	Yes	No	10	6	6
661	R:R:L95	R:R:V93	7.45	No	No	10	6	6
662	R:R:L95	R:R:P94	4.93	No	Yes	10	6	6
663	R:R:P94	R:R:W97	4.05	Yes	Yes	10	6	9
664	R:R:F96	R:R:L99	3.65	No	No	0	4	7
665	R:R:F96	W:W:?2	48.84	No	No	0	4	0
666	R:R:A180	R:R:W97	3.89	No	Yes	0	4	9
667	R:R:F175	R:R:L99	9.74	No	No	0	5	7
668	R:R:N100	W:W:?2	10.33	No	No	0	8	0
669	R:R:F103	W:W:?2	7.63	No	No	0	6	0
670	R:R:C104	R:R:C182	7.28	No	No	0	9	9
671	R:R:H112	R:R:V108	5.54	No	No	0	8	7
672	R:R:A173	R:R:V108	3.39	No	No	0	5	7
673	R:R:M184	R:R:V108	3.04	No	No	0	7	7
674	R:R:P166	R:R:S109	3.56	No	No	0	8	8
675	R:R:F114	R:R:L110	4.87	Yes	No	0	6	6
676	R:R:H112	R:R:Y415	5.44	No	No	0	8	9
677	R:R:L113	R:R:S163	9.01	No	No	0	8	8
678	R:R:A115	R:R:F200	2.77	No	Yes	0	8	8
679	R:R:F116	R:R:Q162	5.86	No	Yes	0	9	8
680	R:R:F116	R:R:F200	13.93	No	Yes	0	9	8
681	R:R:A117	R:R:W156	3.89	No	No	0	9	9
682	R:R:Q446	R:R:S118	5.78	No	No	8	9	9
683	R:R:H450	R:R:S118	2.79	Yes	No	8	9	9
684	R:R:N120	R:R:V119	2.96	Yes	No	0	8	9
685	R:R:P204	R:R:V119	3.53	Yes	No	0	9	9
686	R:R:N120	R:R:T155	2.92	Yes	No	0	8	8
687	R:R:N120	R:R:V158	2.96	Yes	No	36	8	5
688	R:R:N120	R:R:Q162	3.96	Yes	Yes	36	8	8
689	R:R:H450	R:R:I122	5.3	Yes	No	8	9	8
690	R:R:I122	R:R:Y454	8.46	No	Yes	8	8	9
691	R:R:P204	R:R:V123	3.53	Yes	No	0	9	7
692	R:R:D128	R:R:Y139	5.75	No	Yes	35	9	8
693	R:R:D128	R:R:M143	4.16	No	No	35	9	8
694	R:R:R129	R:R:Y212	5.14	Yes	No	0	9	9
695	R:R:R129	R:R:Y454	5.14	Yes	Yes	0	9	9
696	R:R:I134	R:R:Y130	3.63	Yes	No	37	8	8
697	R:R:C211	R:R:Y130	5.38	No	No	0	8	8
698	R:R:V214	R:R:Y130	3.79	No	No	37	7	8
699	R:R:K142	R:R:L131	5.64	No	No	0	6	6
700	R:R:S132	R:R:Y139	7.63	No	Yes	0	8	8
701	R:R:I133	R:R:I134	2.94	No	Yes	0	8	8
702	R:R:I133	R:R:V215	6.14	No	No	0	8	9
703	R:R:H135	R:R:I134	7.95	No	Yes	0	7	8
704	R:R:I134	R:R:V214	3.07	Yes	No	37	8	7
705	R:R:K142	R:R:S138	3.06	No	No	0	6	6
706	R:R:P140	R:R:Y139	4.17	No	Yes	0	7	8
707	R:R:M143	R:R:Y139	9.58	No	Yes	35	8	8
708	R:R:L150	R:R:R146	3.64	No	No	0	4	6
709	R:R:G148	R:R:L151	3.42	No	No	0	8	8
710	R:R:Q162	R:R:V158	7.16	Yes	No	36	8	5
711	R:R:Q162	R:R:S199	5.78	Yes	No	0	8	7
712	R:R:P165	R:R:T164	3.5	Yes	No	0	9	7
713	R:R:T164	R:R:Y168	4.99	No	No	0	7	6
714	R:R:P165	R:R:P166	5.84	Yes	No	18	9	8
715	R:R:P165	R:R:W170	6.76	Yes	Yes	18	9	6
716	R:R:P165	R:R:Y192	4.17	Yes	Yes	18	9	8
717	R:R:P166	R:R:Y192	8.34	No	Yes	18	8	8
718	R:R:L167	R:R:Y168	3.52	No	No	0	8	6
719	R:R:S191	R:R:W170	6.18	No	Yes	0	6	6
720	R:R:W170	R:R:Y192	2.89	Yes	Yes	18	6	8
721	R:R:G171	R:R:S189	3.71	No	No	0	7	6
722	R:R:I185	R:R:Q172	4.12	No	No	0	7	6
723	R:R:A188	R:R:Q172	3.03	No	No	0	5	6
724	R:R:C182	R:R:F175	6.98	No	No	0	9	5
725	R:R:D176	R:R:N179	5.39	No	Yes	0	5	4
726	R:R:N179	R:R:R178	9.64	Yes	No	38	4	3
727	R:R:Q433	R:R:R178	14.02	No	No	38	4	3
728	R:R:N179	R:R:Q433	9.24	Yes	No	38	4	4
729	R:R:I436	R:R:N179	7.08	No	Yes	0	5	4
730	R:R:I440	R:R:L181	2.85	No	No	0	8	4
731	R:R:M184	R:R:Y192	3.59	No	Yes	0	7	8
732	R:R:T193	R:R:W186	12.13	No	Yes	0	8	7
733	R:R:S196	R:R:W186	4.94	No	Yes	0	8	7
734	R:R:W186	R:R:Y415	5.79	Yes	No	0	7	9
735	R:R:A419	R:R:W186	10.37	No	Yes	0	8	7
736	R:R:V197	R:R:V420	4.81	No	No	0	8	7
737	R:R:F200	R:R:L412	4.87	Yes	No	0	8	9
738	R:R:C416	R:R:F200	4.19	No	Yes	0	8	8
739	R:R:C416	R:R:I201	4.91	No	No	0	8	8
740	R:R:I203	R:R:P204	3.39	No	Yes	0	6	9
741	R:R:P204	R:R:Y408	4.17	Yes	No	0	9	9
742	R:R:L205	R:R:V409	2.98	Yes	No	0	7	7
743	R:R:I405	R:R:M208	2.92	No	No	0	8	9
744	R:R:I401	R:R:Y212	6.04	No	No	0	9	9
745	R:R:I404	R:R:Y212	3.63	No	No	0	9	9
746	R:R:S213	R:R:V214	3.23	No	No	0	4	7
747	R:R:F216	R:R:R220	3.21	No	No	0	7	7
748	R:R:L225	R:R:R221	4.86	No	No	0	5	5
749	R:R:H223	R:R:Y227	9.8	No	No	0	6	4
750	R:R:I403	R:R:K399	4.36	No	No	0	8	6
751	R:R:F402	R:R:F406	4.29	No	No	0	7	8
752	R:R:I403	R:R:M457	2.92	No	No	0	8	9
753	R:R:I449	R:R:S407	3.1	No	No	0	7	7
754	R:R:L410	R:R:L442	2.77	No	No	0	5	9
755	R:R:Q446	R:R:S411	2.89	No	No	0	9	9
756	R:R:G413	R:R:P414	4.06	No	No	0	7	9
757	R:R:I439	R:R:P414	3.39	No	No	0	7	9
758	R:R:L442	R:R:P414	3.28	No	No	0	9	9
759	R:R:F443	R:R:Y415	12.38	No	No	0	8	9
760	R:R:L418	R:R:V427	4.47	No	No	0	6	4
761	R:R:I439	R:R:L418	5.71	No	No	0	7	6
762	R:R:L421	R:R:V425	2.98	No	No	0	7	8
763	R:R:V423	R:R:W424	19.61	No	No	0	8	7
764	R:R:V427	R:R:V431	4.81	No	Yes	0	4	6
765	R:R:P432	R:R:V431	3.53	No	Yes	19	7	6
766	R:R:V431	R:R:V435	3.21	Yes	No	19	6	5
767	R:R:P432	R:R:W434	9.46	No	No	19	7	4
768	R:R:P432	R:R:V435	5.3	No	No	19	7	5
769	R:R:V435	R:R:W434	8.58	No	No	19	5	4
770	R:R:T437	R:R:W441	4.85	No	Yes	11	6	8
771	R:R:I438	R:R:L442	2.85	No	No	0	6	9
772	R:R:W441	W:W:?1	11.42	Yes	No	11	8	0
773	R:R:I449	R:R:L445	2.85	No	No	0	7	7
774	R:R:H450	R:R:Q446	11.13	Yes	No	8	9	9
775	R:R:Y452	R:R:Y456	7.94	No	Yes	0	7	7
776	R:R:V453	R:R:Y454	10.09	No	Yes	0	9	9
777	R:R:K462	R:R:Y456	4.78	No	Yes	29	9	7
778	R:R:Q466	R:R:Y456	4.51	No	Yes	29	7	7
779	R:R:H458	R:R:T460	9.58	Yes	No	0	9	8
780	R:R:H458	R:R:I461	5.3	Yes	Yes	28	9	8
781	R:R:I461	R:R:I465	2.94	Yes	Yes	0	8	8
782	R:R:K462	R:R:Q466	5.42	No	No	29	9	7
783	R:R:D467	R:R:K463	4.15	No	No	0	6	6
784	R:R:F472	R:R:F473	13.93	No	No	0	2	4
785	A:A:L388	A:A:Q384	2.66	No	Yes	0	8	6
786	A:A:H387	A:A:I383	2.65	No	No	0	8	8
787	R:R:F200	R:R:S196	2.64	Yes	No	0	8	8
788	B:B:F199	B:B:V213	2.62	Yes	No	0	9	4
789	R:R:F41	R:R:V37	2.62	No	Yes	0	7	6
790	R:R:F69	R:R:V65	2.62	Yes	No	0	8	7
791	R:R:F69	R:R:V125	2.62	Yes	No	0	8	9
792	R:R:R129	R:R:V125	2.62	Yes	No	0	9	9
793	A:A:D381	R:R:Q222	2.61	No	No	0	8	8
794	B:B:D247	B:B:E226	2.6	Yes	No	0	9	3
795	B:B:R49	B:B:T87	2.59	No	No	0	7	5
796	R:R:F175	R:R:T91	2.59	No	No	0	5	7
797	R:R:F443	R:R:T111	2.59	No	No	0	8	9
798	R:R:R147	R:R:T144	2.59	No	No	0	8	9
799	B:B:S147	B:B:Y145	2.54	No	Yes	0	9	8
800	B:B:V71	B:B:Y105	2.52	No	Yes	0	8	6
801	B:B:V112	B:B:Y105	2.52	No	Yes	0	8	6
802	A:A:I62	A:A:R61	2.51	No	No	0	9	8
803	A:A:I276	A:A:R231	2.51	No	No	0	8	9
804	A:A:F345	A:A:I341	2.51	Yes	No	0	8	8
805	R:R:F46	R:R:I50	2.51	No	No	0	7	6
806	R:R:F216	R:R:I401	2.51	No	No	0	7	9
807	A:A:T335	A:A:Y339	2.5	No	Yes	0	4	3
808	A:A:K307	A:A:R333	2.48	No	No	0	6	5
809	R:R:M468	R:R:R58	2.48	No	No	0	7	8
810	R:R:S189	R:R:W170	2.47	No	Yes	0	6	6
811	B:B:F222	B:B:L255	2.44	Yes	No	1	8	6
812	B:B:F234	B:B:L255	2.44	Yes	No	1	5	6
813	B:B:F241	B:B:L255	2.44	Yes	No	1	6	6
814	R:R:F114	R:R:L113	2.44	Yes	No	0	6	8
815	R:R:F406	R:R:L410	2.44	No	No	0	8	5
816	R:R:F473	R:R:L469	2.44	No	No	0	4	8
817	A:A:L346	A:A:R342	2.43	No	Yes	0	4	4
818	B:B:L7	G:G:R13	2.43	Yes	No	0	8	6
819	B:B:L192	B:B:R150	2.43	No	No	0	5	6
820	R:R:I465	R:R:Y456	2.42	Yes	Yes	0	8	7
821	G:G:N59	G:G:R62	2.41	No	No	0	9	7
822	R:R:M208	R:R:Y408	2.39	No	No	0	9	9
823	A:A:R228	B:B:D186	2.38	No	Yes	0	9	9
824	R:R:L226	R:R:Y227	2.34	Yes	No	0	5	4
825	A:A:N264	A:A:Y311	2.33	No	No	0	9	6
826	R:R:L38	R:R:W441	2.28	No	Yes	0	6	8
827	R:R:L107	R:R:W87	2.28	No	No	0	7	6
828	R:R:L195	R:R:W170	2.28	No	Yes	0	6	6
829	A:A:N279	A:A:W281	2.26	No	Yes	0	8	5
830	B:B:G115	B:B:G116	2.11	No	No	0	9	9
831	B:B:G324	G:G:P49	2.03	No	No	0	9	7
832	B:B:C271	B:B:G272	1.96	Yes	No	0	5	4
833	B:B:C317	B:B:G330	1.96	No	No	0	7	5
834	A:A:A303	A:A:G304	1.95	No	No	0	5	5
835	B:B:A106	B:B:G109	1.95	No	No	0	6	5
836	B:B:A140	B:B:G141	1.95	No	No	0	5	5
837	B:B:A309	B:B:G310	1.95	No	No	0	3	5
838	A:A:A39	R:R:P140	1.87	No	No	0	5	7
839	R:R:A85	R:R:P86	1.87	No	No	0	8	9
840	A:A:G52	A:A:S51	1.86	No	No	0	9	9
841	A:A:G52	A:A:S366	1.86	No	No	0	9	9
842	A:A:G353	A:A:S352	1.86	No	No	0	4	5
843	B:B:G77	B:B:S98	1.86	No	No	0	8	8
844	B:B:G288	B:B:S275	1.86	No	No	0	7	8
845	B:B:G319	B:B:S277	1.86	No	No	0	5	5
846	R:R:G31	R:R:S92	1.86	No	No	0	5	6
847	B:B:G244	B:B:V276	1.84	No	No	0	5	6
848	B:B:G306	B:B:V296	1.84	No	No	0	4	5
849	R:R:G48	R:R:V47	1.84	No	No	0	9	6
850	B:B:G115	B:B:T102	1.82	No	No	0	9	8
851	B:B:A60	B:B:C103	1.81	No	No	0	7	8
852	B:B:A104	B:B:C149	1.81	No	No	0	7	8
853	B:B:A113	B:B:C149	1.81	No	No	0	9	8
854	R:R:A398	R:R:C395	1.81	No	No	0	8	7
855	R:R:A117	R:R:A159	1.79	No	No	0	9	9
856	R:R:A219	R:R:A397	1.79	No	No	0	8	8
857	R:R:P190	R:R:S189	1.78	No	No	0	5	6
858	R:R:G154	R:R:I157	1.76	No	No	0	5	5
859	R:R:G413	R:R:I201	1.76	No	No	0	7	8
860	R:R:G455	R:R:I461	1.76	No	Yes	0	9	8
861	A:A:P326	A:A:T325	1.75	No	No	0	1	2
862	B:B:P107	B:B:T65	1.75	No	No	0	6	1
863	G:G:P53	G:G:T52	1.75	No	No	0	8	4
864	B:B:G53	B:B:K89	1.74	No	Yes	0	9	9
865	A:A:G47	A:A:L46	1.71	No	Yes	0	9	8
866	B:B:A56	B:B:S74	1.71	No	No	0	7	9
867	B:B:G174	B:B:L139	1.71	No	Yes	0	4	9
868	B:B:C233	B:B:V276	1.71	No	No	0	3	6
869	R:R:C211	R:R:V127	1.71	No	No	0	8	7
870	R:R:C416	R:R:V197	1.71	No	No	0	8	8
871	R:R:C211	R:R:V207	1.71	No	No	0	8	7
872	A:A:A269	A:A:V248	1.7	No	No	0	9	7
873	A:A:A298	A:A:V334	1.7	No	Yes	0	4	4
874	A:A:A337	A:A:V301	1.7	No	No	0	8	7
875	B:B:A11	G:G:V16	1.7	No	No	0	5	7
876	B:B:A305	B:B:V40	1.7	No	Yes	0	4	3
877	B:B:A257	G:G:V30	1.7	No	No	0	7	8
878	A:A:D354	A:A:G353	1.68	No	No	0	3	4
879	A:A:D354	A:A:G355	1.68	No	No	0	3	2
880	R:R:A173	R:R:T105	1.68	No	No	0	5	7
881	A:A:C379	A:A:I375	1.64	No	No	0	8	9
882	R:R:G171	R:R:Q172	1.64	No	No	0	7	6
883	R:R:S138	R:R:S141	1.63	No	No	0	6	5
884	A:A:I26	B:B:A92	1.62	No	No	0	9	6
885	A:A:A243	A:A:I288	1.62	No	No	0	8	9
886	A:A:A243	A:A:I382	1.62	No	No	0	8	6
887	A:A:A337	A:A:I308	1.62	No	No	0	8	7
888	B:B:A28	B:B:I33	1.62	No	No	0	4	3
889	B:B:I33	G:G:A34	1.62	No	No	0	3	6
890	B:B:A140	B:B:I120	1.62	No	No	0	5	6
891	B:B:A248	B:B:I269	1.62	No	No	0	5	4
892	R:R:S126	R:R:V127	1.62	No	No	0	9	7
893	R:R:S126	R:R:V207	1.62	No	No	0	9	7
894	R:R:A218	R:R:I134	1.62	No	Yes	0	7	8
895	R:R:S407	R:R:V453	1.62	No	No	0	7	9
896	A:A:S54	A:A:T55	1.6	No	No	0	9	9
897	B:B:S31	B:B:T29	1.6	No	No	0	1	3
898	B:B:S207	B:B:T223	1.6	No	No	0	5	2
899	R:R:V39	R:R:V89	1.6	No	No	0	5	7
900	R:R:V47	R:R:V51	1.6	No	No	0	6	8
901	A:A:T55	A:A:V367	1.59	No	No	0	9	9
902	A:A:T210	A:A:V57	1.59	No	No	0	7	7
903	A:A:T335	A:A:V334	1.59	No	Yes	0	4	4
904	R:R:G31	R:R:H30	1.59	No	No	0	5	5
905	B:B:A11	G:G:L19	1.58	No	Yes	0	5	9
906	R:R:A85	R:R:L42	1.58	No	No	0	8	8
907	A:A:T204	B:B:T143	1.57	No	No	0	9	5
908	A:A:A19	B:B:N88	1.56	No	Yes	0	4	7
909	A:A:A226	B:B:N119	1.56	No	Yes	0	9	9
910	G:G:A23	G:G:N24	1.56	No	No	0	8	1
911	B:B:A240	B:B:D254	1.54	No	Yes	0	6	9
912	B:B:D254	G:G:A33	1.54	Yes	No	0	9	7
913	R:R:I33	R:R:V37	1.54	No	Yes	0	4	6
914	R:R:I465	R:R:V51	1.54	Yes	No	0	8	8
915	R:R:I203	R:R:V198	1.54	No	No	0	6	6
916	R:R:I206	R:R:V202	1.54	No	No	0	4	6
917	R:R:I404	R:R:V400	1.54	No	No	0	9	9
918	R:R:I436	R:R:V431	1.54	No	Yes	0	5	6
919	B:B:Q17	G:G:A23	1.52	No	No	0	4	8
920	R:R:I32	R:R:T36	1.52	No	No	0	6	5
921	R:R:I160	R:R:T164	1.52	No	No	0	5	7
922	B:B:F253	B:B:G224	1.51	Yes	No	0	6	6
923	R:R:F69	R:R:G148	1.51	Yes	No	0	8	8
924	A:A:L291	A:A:S250	1.5	No	No	0	8	6
925	A:A:L296	A:A:S251	1.5	No	No	0	6	9
926	R:R:L28	R:R:S92	1.5	Yes	No	0	6	6
927	B:B:L7	G:G:V16	1.49	Yes	No	0	8	7
928	R:R:L38	R:R:V88	1.49	No	No	0	6	8
929	R:R:L107	R:R:V84	1.49	No	No	0	7	9
930	R:R:L421	R:R:V427	1.49	No	No	0	7	4
931	B:B:D322	B:B:S67	1.47	No	No	0	1	5
932	R:R:I209	R:R:I405	1.47	No	No	39	7	8
933	A:A:N218	A:A:T40	1.46	No	No	0	4	7
934	A:A:D331	A:A:V334	1.46	Yes	Yes	0	4	4
935	B:B:A206	B:B:H225	1.46	No	Yes	0	4	9
936	R:R:G154	R:R:Y153	1.45	No	No	0	5	6
937	R:R:G169	R:R:Y168	1.45	No	No	0	7	6
938	A:A:F312	A:A:P313	1.44	No	No	0	8	6
939	B:B:I18	G:G:L19	1.43	No	Yes	0	7	9
940	R:R:I32	R:R:L28	1.43	No	Yes	0	6	6
941	R:R:I50	R:R:L54	1.43	No	No	0	6	5
942	R:R:I157	R:R:L161	1.43	No	No	0	5	6
943	R:R:I201	R:R:L205	1.43	No	Yes	0	8	7
944	R:R:I209	R:R:L205	1.43	No	Yes	39	7	7
945	R:R:I405	R:R:L205	1.43	No	Yes	39	8	7
946	R:R:I465	R:R:L469	1.43	Yes	No	0	8	8
947	B:B:Q175	B:B:T173	1.42	No	No	0	4	5
948	A:A:R232	B:B:C204	1.39	No	Yes	0	8	7
949	B:B:C25	G:G:R27	1.39	No	Yes	0	3	8
950	B:B:H54	B:B:S334	1.39	Yes	No	0	9	4
951	B:B:A299	B:B:F278	1.39	No	Yes	0	5	7
952	A:A:A48	A:A:R265	1.38	No	Yes	0	8	9
953	A:A:A316	A:A:R336	1.38	No	No	0	2	5
954	B:B:I37	G:G:E42	1.37	No	No	0	2	1
955	A:A:K216	A:A:Q213	1.36	No	No	0	4	3
956	A:A:D378	A:A:N377	1.35	Yes	No	0	7	4
957	B:B:D267	B:B:N268	1.35	No	No	0	3	4
958	R:R:P98	R:R:W97	1.35	No	Yes	0	4	9
959	R:R:H135	R:R:L131	1.29	No	No	0	7	6
960	R:R:R146	R:R:T144	1.29	No	No	0	6	9
961	B:B:E12	B:B:Q9	1.27	No	No	0	4	3
962	R:R:V425	R:R:W424	1.23	No	No	0	8	7
963	R:R:F114	R:R:L83	1.22	Yes	No	0	6	6
964	B:B:F292	B:B:N313	1.21	No	No	0	4	7
965	A:A:D49	A:A:R265	1.19	No	Yes	0	8	9
966	A:A:D381	R:R:R221	1.19	No	No	0	8	5
967	A:A:Q59	A:A:Y63	1.13	No	No	0	9	9
968	R:R:F103	R:R:W87	1	No	No	0	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	A:A:K34	4.46	4	20	4
2	A:A:H41	4.1375	4	22	6
3	A:A:L46	3.4375	4	23	8
4	A:A:F212	5.55	4	0	9
5	A:A:F219	5.63	5	22	8
6	A:A:Q227	3.8325	4	4	9
7	A:A:K233	4.7125	4	4	9
8	A:A:W234	4.942	5	0	9
9	A:A:F238	5.942	5	0	9
10	A:A:R265	5.03	5	24	9
11	A:A:L270	5.4725	4	0	6
12	A:A:W277	7.616	5	25	6
13	A:A:W281	8.296	5	2	5
14	A:A:N292	4.65	5	0	9
15	A:A:D331	5.2075	4	0	4
16	A:A:V334	1.9325	4	0	4
17	A:A:Y339	4.9875	4	0	3
18	A:A:R342	4.65	4	0	4
19	A:A:F345	5.806	5	0	8
20	A:A:Y358	4.818	5	14	4
21	A:A:Y360	5.51	4	14	8
22	A:A:F363	7.16	4	26	5
23	A:A:T364	6.3625	4	12	9
24	A:A:N371	3.635	4	12	9
25	A:A:R374	5.405	4	12	4
26	A:A:D378	7.355	4	0	7
27	A:A:Q384	4.005	4	27	6
28	A:A:R385	8.295	4	14	5
29	A:A:L393	2.9375	4	0	8
30	B:B:L7	3.43	4	0	8
31	B:B:L30	4.385	4	0	5
32	B:B:V40	4.9575	4	15	3
33	B:B:H54	6.665	6	5	9
34	B:B:K57	7.322	5	2	9
35	B:B:Y59	5.238	5	2	8
36	B:B:W63	5.135	4	0	7
37	B:B:Q75	7.4075	4	2	9
38	B:B:D76	8.1375	4	0	9
39	B:B:W82	7.28429	7	5	9
40	B:B:N88	4.075	4	0	7
41	B:B:K89	5.552	5	5	9
42	B:B:H91	4.9425	4	0	5
43	B:B:L95	4.0675	4	16	8
44	B:B:W99	6.746	5	0	9
45	B:B:Y105	3.435	4	0	6
46	B:B:N119	3.925	4	0	9
47	B:B:I123	3.838	5	33	6
48	B:B:Y124	5.345	4	16	6
49	B:B:T128	4.8675	4	17	3
50	B:B:L139	5.1375	4	0	9
51	B:B:H142	5.64429	7	6	9
52	B:B:Y145	4.52429	7	4	8
53	B:B:D163	7.8025	4	6	9
54	B:B:W169	7.26167	6	6	8
55	B:B:F180	7.474	5	3	7
56	B:B:H183	7.142	5	3	9
57	B:B:D186	4.762	5	4	9
58	B:B:L198	4.065	4	0	3
59	B:B:F199	6.976	5	3	9
60	B:B:V200	4.035	4	1	6
61	B:B:S201	4.9825	4	3	9
62	B:B:C204	4.384	5	4	7
63	B:B:K209	9.2675	4	3	6
64	B:B:W211	9.498	5	3	8
65	B:B:F222	5.85	5	1	8
66	B:B:H225	6.59714	7	1	9
67	B:B:D228	6.37	4	4	9
68	B:B:I232	3.52	5	1	8
69	B:B:F234	3.95	4	1	5
70	B:B:F235	5.14143	7	7	6
71	B:B:P236	4.585	4	7	7
72	B:B:F241	5.654	5	1	6
73	B:B:T243	4.122	5	1	8
74	B:B:D247	6.5625	4	1	9
75	B:B:T249	4.6225	4	1	6
76	B:B:R251	8.786	5	1	8
77	B:B:F253	5.07	6	1	6
78	B:B:D254	5.32	4	0	9
79	B:B:D258	7.295	4	1	7
80	B:B:M262	5.43	4	0	4
81	B:B:Y264	5.522	5	0	5
82	B:B:C271	3.83	4	2	5
83	B:B:F278	3.67	5	7	7
84	B:B:Y289	4.95571	7	2	7
85	B:B:D290	4.7025	4	2	6
86	B:B:D298	6.8625	4	15	9
87	B:B:L300	6.71	4	15	6
88	B:B:H311	7.592	5	9	9
89	B:B:R314	8.305	4	2	8
90	B:B:W332	7.48167	6	2	9
91	B:B:L336	3.7025	4	5	7
92	B:B:K337	5.375	4	0	6
93	B:B:W339	7.79333	6	0	9
94	G:G:L19	2.15	4	0	9
95	G:G:R27	4.0325	4	0	8
96	G:G:Y40	6.2875	4	7	6
97	G:G:L51	5.6025	4	0	6
98	G:G:F61	5.226	5	31	8
99	R:R:L28	3.23	4	10	6
100	R:R:V37	4.425	4	11	6
101	R:R:N49	4.77	4	0	9
102	R:R:L56	4.055	4	0	8
103	R:R:L63	3.878	5	28	8
104	R:R:F69	3.655	4	0	8
105	R:R:L73	3.9075	4	8	9
106	R:R:D77	4.11	4	0	9
107	R:R:P94	4.77	4	10	6
108	R:R:W97	3.1775	4	10	9
109	R:R:F114	4.798	5	0	6
110	R:R:N120	3.2	4	36	8
111	R:R:R129	6.3125	4	0	9
112	R:R:I134	3.842	5	37	8
113	R:R:Y139	6.7825	4	35	8
114	R:R:Q162	5.69	4	36	8
115	R:R:P165	5.0675	4	18	9
116	R:R:W170	4.116	5	18	6
117	R:R:N179	7.8375	4	38	4
118	R:R:W186	8.3075	4	0	7
119	R:R:Y192	4.7475	4	18	8
120	R:R:F200	5.68	5	0	8
121	R:R:P204	3.655	4	0	9
122	R:R:L205	1.8175	4	39	7
123	R:R:L226	4.605	4	14	5
124	R:R:V431	3.2725	4	19	6
125	R:R:W441	6.472	5	11	8
126	R:R:H450	6.132	5	8	9
127	R:R:Y454	7.095	4	8	9
128	R:R:Y456	4.9125	4	29	7
129	R:R:H458	6.59	4	28	9
130	R:R:I461	3.14	5	28	8
131	R:R:I465	2.894	5	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	B:B:S84	B:B:W63	10.6317	6.18	No	Yes	0	5	7
2	B:B:L70	B:B:W63	16.9606	6.83	No	Yes	0	5	7
3	B:B:L70	B:B:W82	17.3237	4.56	No	Yes	0	5	9
4	B:B:H54	B:B:W82	20.5139	3.17	Yes	Yes	5	9	9
5	B:B:H54	B:B:S74	23.0695	12.55	Yes	No	0	9	9
6	B:B:D76	B:B:S74	23.7751	7.36	Yes	No	0	9	9
7	B:B:D76	B:B:K78	17.7003	6.91	Yes	No	0	9	8
8	B:B:K78	B:B:P94	16.2457	3.35	No	No	0	8	5
9	B:B:I93	B:B:P94	15.8805	3.39	No	No	0	7	5
10	B:B:D76	B:B:L55	40.6337	14.93	Yes	No	0	9	6
11	A:A:K34	B:B:L55	80.8983	5.64	Yes	No	0	4	6
12	A:A:K34	R:R:Q64	80.4793	2.71	Yes	No	20	4	8
13	A:A:Y37	B:B:L55	87.4416	3.52	No	No	0	4	6
14	A:A:R42	A:A:Y37	87.5827	12.35	No	No	0	9	4
15	A:A:R38	R:R:Q64	80.538	21.03	No	No	0	4	8
16	A:A:R38	R:R:P140	80.4483	2.88	No	No	0	4	7
17	A:A:F212	A:A:M60	16.2381	4.98	Yes	No	0	9	9
18	A:A:M60	A:A:Q59	16.789	8.16	No	No	0	9	9
19	A:A:N371	A:A:Q59	17.8891	3.96	Yes	No	0	9	9
20	A:A:N371	A:A:R374	18.1699	3.62	Yes	Yes	12	9	4
21	A:A:H362	A:A:R374	33.0193	6.77	No	Yes	0	9	4
22	A:A:D378	A:A:H362	47.3007	8.82	Yes	No	0	7	9
23	A:A:D378	A:A:Y360	48.8429	8.05	Yes	Yes	0	7	8
24	A:A:R385	A:A:Y360	13.8864	6.17	Yes	Yes	14	5	8
25	A:A:R385	R:R:Q222	42.2669	11.68	Yes	No	0	5	8
26	A:A:Q384	R:R:Q222	41.1578	5.12	Yes	No	0	6	8
27	A:A:L388	A:A:Q384	39.7926	2.66	No	Yes	0	8	6
28	A:A:L388	A:A:L393	34.9066	2.77	No	Yes	0	8	8
29	A:A:L393	R:R:I401	37.6244	2.85	Yes	No	0	8	9
30	R:R:I401	R:R:Y212	38.2431	6.04	No	No	0	9	9
31	R:R:R129	R:R:Y212	38.8744	5.14	Yes	No	0	9	9
32	A:A:Y391	R:R:R129	75.2022	12.35	No	Yes	0	4	9
33	A:A:Y391	R:R:H458	75.2534	7.62	No	Yes	0	4	9
34	R:R:H458	R:R:L63	71.8082	3.86	Yes	Yes	28	9	8
35	R:R:L63	R:R:T66	79.8305	4.42	Yes	No	0	8	8
36	R:R:D128	R:R:T66	79.9169	4.34	No	No	0	9	8
37	R:R:D128	R:R:Y139	79.8555	5.75	No	Yes	35	9	8
38	R:R:P140	R:R:Y139	80.2694	4.17	No	Yes	0	7	8
39	A:A:F222	A:A:R42	87.9874	3.21	No	No	0	7	9
40	A:A:F222	B:B:W99	88.724	10.02	No	Yes	0	7	9
41	A:A:F238	A:A:L44	40.075	10.96	Yes	No	0	9	9
42	A:A:L44	A:A:L46	39.7173	5.54	No	Yes	23	9	8
43	A:A:F246	A:A:L46	39.969	3.65	No	Yes	0	9	8
44	A:A:D249	A:A:K293	13.3914	17.97	No	No	0	9	9
45	A:A:K293	A:A:N292	14.5035	4.2	No	Yes	0	9	9
46	A:A:N292	A:A:T364	25.591	4.39	Yes	Yes	0	9	9
47	A:A:F290	A:A:T364	13.2259	11.67	No	Yes	0	9	9
48	A:A:F290	A:A:H362	13.7584	5.66	No	No	0	9	9
49	A:A:R374	A:A:T364	13.2298	6.47	Yes	Yes	12	4	9
50	B:B:L117	B:B:W99	17.7479	5.69	No	Yes	0	9	9
51	B:B:L117	B:B:Y145	16.8173	3.52	No	Yes	4	9	8
52	A:A:R231	A:A:W234	19.9991	6	No	Yes	0	9	9
53	A:A:D272	A:A:R231	19.6704	10.72	No	No	0	8	9
54	B:B:Q75	B:B:W99	64.3372	5.48	Yes	Yes	0	9	9
55	B:B:K57	B:B:Q75	32.3098	6.78	Yes	Yes	2	9	9
56	B:B:K57	B:B:W332	31.0809	13.92	Yes	Yes	2	9	9
57	B:B:R314	B:B:W332	100	12	Yes	Yes	2	8	9
58	B:B:Q75	B:B:Y59	32.1493	11.27	Yes	Yes	2	9	8
59	B:B:W332	B:B:Y59	70.6441	3.86	Yes	Yes	2	9	8
60	A:A:C237	A:A:F238	32.9465	2.79	No	Yes	0	8	9
61	A:A:F246	A:A:L289	59.6342	3.65	No	No	0	9	9
62	A:A:F345	A:A:L289	68.4004	4.87	Yes	No	0	8	9
63	A:A:F345	A:A:L270	25.9899	9.74	Yes	Yes	0	8	6
64	A:A:I348	A:A:L270	25.3686	2.85	No	Yes	0	4	6
65	A:A:F273	A:A:I348	22.0799	6.28	No	No	0	9	4
66	A:A:F273	A:A:F345	44.5109	5.36	No	Yes	0	9	8
67	A:A:C359	A:A:F273	22.5926	2.79	No	No	0	5	9
68	A:A:I348	A:A:K274	47.1926	4.36	No	No	0	4	5
69	A:A:K274	A:A:N278	46.9957	4.2	No	No	0	5	8
70	A:A:C359	A:A:S349	22.5541	3.44	No	No	0	5	7
71	A:A:S349	A:A:W277	22.4776	3.71	No	Yes	0	7	6
72	A:A:N278	A:A:S352	46.775	5.96	No	No	25	8	5
73	A:A:S352	A:A:W277	22.4039	4.94	No	Yes	25	5	6
74	B:B:D290	B:B:R314	73.1226	8.34	Yes	Yes	2	6	8
75	A:A:L289	A:A:L291	20.5046	2.77	No	No	0	9	8
76	A:A:F363	A:A:L291	19.3859	3.65	Yes	No	0	5	8
77	A:A:T335	A:A:Y339	13.7166	2.5	No	Yes	0	4	3
78	A:A:T335	A:A:V334	10.2955	1.59	No	Yes	0	4	4
79	A:A:D354	A:A:G355	68.0954	1.68	No	No	0	3	2
80	A:A:D354	A:A:G353	68.4558	1.68	No	No	0	3	4
81	A:A:G353	A:A:S352	68.8167	1.86	No	No	0	4	5
82	A:A:R385	A:A:Y358	28.1779	9.26	Yes	Yes	14	5	4
83	A:A:G355	A:A:Y358	67.7372	2.9	No	Yes	0	2	4
84	B:B:C271	B:B:D290	74.4433	3.11	Yes	Yes	2	5	6
85	B:B:C271	B:B:Y289	72.0521	4.03	Yes	Yes	2	5	7
86	B:B:I273	B:B:Y289	42.4255	10.88	No	Yes	0	6	7
87	B:B:G244	B:B:I273	43.2269	3.53	No	No	0	5	6
88	B:B:G244	B:B:T243	41.2388	3.64	No	Yes	0	5	8
89	B:B:F253	B:B:T243	20.9847	3.89	Yes	Yes	1	6	8
90	B:B:F222	B:B:F253	16.4121	6.43	Yes	Yes	1	8	6
91	B:B:D258	B:B:F222	12.8893	4.78	Yes	Yes	1	7	8
92	B:B:D258	B:B:R22	10.2193	7.15	Yes	No	0	7	6
93	B:B:W297	B:B:Y289	25.6585	2.89	No	Yes	2	8	7
94	B:B:W297	B:B:Y264	25.2647	5.79	No	Yes	0	8	5
95	B:B:R314	B:B:T274	22.7233	3.88	Yes	No	2	8	8
96	B:B:S275	B:B:T274	23.7179	3.2	No	No	0	8	8
97	B:B:L318	B:B:S275	22.6889	3	No	No	0	6	8
98	B:B:L318	B:B:S277	15.2989	3	No	No	0	6	5
99	B:B:S277	B:B:V320	14.2217	4.85	No	No	0	5	7
100	B:B:V320	B:B:V327	13.6822	3.21	No	No	0	7	6
101	B:B:V327	B:B:W339	13.1422	3.68	No	Yes	0	6	9
102	B:B:M101	B:B:Y145	10.2256	3.59	No	Yes	0	9	8
103	B:B:S147	B:B:Y145	18.9102	2.54	No	Yes	0	9	8
104	B:B:S147	B:B:S160	18.5387	3.26	No	No	0	9	6
105	B:B:S160	B:B:V187	18.1666	6.46	No	No	0	6	9
106	B:B:S201	B:B:V187	11.6044	3.23	Yes	No	3	9	9
107	B:B:S201	B:B:W211	10.9253	7.41	Yes	Yes	3	9	8
108	B:B:I93	B:B:L79	10.3307	4.28	No	No	0	7	7
109	B:B:G162	B:B:Y145	15.922	5.79	No	Yes	0	9	8
110	B:B:G162	B:B:S161	15.5457	3.71	No	No	0	9	9
111	B:B:H142	B:B:S161	12.8351	13.95	Yes	No	6	9	9
112	B:B:I232	B:B:T243	14.7263	4.56	Yes	Yes	1	8	8
113	B:B:L285	B:B:Y264	12.5142	4.69	No	Yes	0	6	5
114	B:B:F278	B:B:L285	11.9973	4.87	Yes	No	0	7	6
115	R:R:R129	R:R:Y454	91.9633	5.14	Yes	Yes	0	9	9
116	R:R:V453	R:R:Y454	11.7158	10.09	No	Yes	0	9	9
117	R:R:S407	R:R:V453	11.3202	1.62	No	No	0	7	9
118	R:R:I449	R:R:S407	10.9241	3.1	No	No	0	7	7
119	R:R:I449	R:R:L445	10.5273	2.85	No	No	0	7	7
120	R:R:F41	R:R:L445	10.1299	6.09	No	No	0	7	7
121	R:R:L73	R:R:Y454	43.1962	4.69	Yes	Yes	8	9	9
122	R:R:H450	R:R:L73	41.0889	5.14	Yes	Yes	8	9	9
123	R:R:D77	R:R:H450	79.391	6.3	Yes	Yes	0	9	9
124	R:R:C447	R:R:D77	72.2779	3.11	No	Yes	0	9	9
125	R:R:I122	R:R:Y454	41.1714	8.46	No	Yes	8	8	9
126	R:R:H450	R:R:I122	40.87	5.3	Yes	No	8	9	8
127	R:R:C447	R:R:Q80	67.7134	3.05	No	No	0	9	8
128	R:R:Q80	R:R:T111	62.4608	2.83	No	No	0	8	9
129	R:R:F443	R:R:T111	53.8424	2.59	No	No	0	8	9
130	R:R:F443	R:R:Y415	53.1753	12.38	No	No	0	8	9
131	R:R:H112	R:R:Y415	16.2571	5.44	No	No	0	8	9
132	R:R:H112	R:R:V108	15.5572	5.54	No	No	0	8	7
133	R:R:M184	R:R:V108	13.4528	3.04	No	No	0	7	7
134	R:R:M184	R:R:Y192	12.7502	3.59	No	Yes	0	7	8
135	R:R:W186	R:R:Y415	36.9841	5.79	Yes	No	0	7	9
136	R:R:S196	R:R:W186	34.9358	4.94	No	Yes	0	8	7
137	R:R:F200	R:R:S196	34.2518	2.64	Yes	No	0	8	8
138	R:R:I133	R:R:I134	10.6612	2.94	No	Yes	0	8	8
139	R:R:C416	R:R:F200	23.866	4.19	No	Yes	0	8	8
140	R:R:C416	R:R:I201	21.7879	4.91	No	No	0	8	8
141	R:R:G413	R:R:I201	16.957	1.76	No	No	0	7	8
142	R:R:G413	R:R:P414	16.2574	4.06	No	No	0	7	9
143	R:R:I439	R:R:P414	12.047	3.39	No	No	0	7	9
144	R:R:I439	R:R:L418	11.3431	5.71	No	No	0	7	6
145	R:R:L418	R:R:V427	10.6387	4.47	No	No	0	6	4
146	A:A:Y358	A:A:Y360	37.0681	2.98	Yes	Yes	14	4	8
147	A:A:D272	A:A:F246	19.5108	8.36	No	No	0	8	9
148	A:A:W234	B:B:Y145	18.6703	4.82	Yes	Yes	0	9	8
149	A:A:C237	B:B:Y59	32.1246	2.69	No	Yes	2	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:R34	R:R:T437	6.47	11	No	No	5	6	2	2
R:R:R34	R:R:W441	4	11	No	Yes	5	8	2	1
R:R:V37	R:R:W441	9.81	11	Yes	Yes	6	8	1	1
R:R:V37	W:W:?1	3.73	11	Yes	No	6	0	1	0
R:R:T437	R:R:W441	4.85	11	No	Yes	6	8	2	1
R:R:W441	W:W:?1	11.42	11	Yes	No	8	0	1	0
R:R:F41	R:R:V37	2.62	0	No	Yes	7	6	2	1
R:R:L38	R:R:W441	2.28	0	No	Yes	6	8	2	1
R:R:I33	R:R:V37	1.54	0	No	Yes	4	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
50.00	Single	8W8S	AA-14	8W8S-GPR101-AA-14
28.57	Single	7F61	Cholesterol	7F61-H₃-PF-03654746-Cholesterol
16.67	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
16.67	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
16.67	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
16.67	Consensus	ep_off	Orthosteric Ligand	ep4_off
15.38	Single	9BJK	NAM	9BJK-μ-Naloxone-NAM
11.11	Single	9B9Y	7DY	9B9Y-CB₁-7DY
10.00	Single	5U09	Taranabant	5U09-CB₁-Taranabant
10.00	Single	9BA0	A1AKN	9BA0-CB₁-A1AKN
9.09	Single	8JD6	N-(3-chlorophenyl)pyridine-2-carboxamide	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
9.09	Single	8K2W	AMG487	8K2W-CXCR3-AMG487
9.09	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/β1/γ2
9.09	Consensus	cb1_off	Orthosteric Ligand	5U09-CB₁-Taranabant 5TGZ-CB₁-AM6538
9.09	Consensus	cxcr3_off	Orthosteric Ligand	8K2W-CXCR3-AMG487
8.33	Single	2Y01	Dobutamine	2Y01-β₁-Dobutamine
8.33	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
8.33	Single	6IIV	Daltroban	6IIV-TP-Daltroban
8.33	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
8.33	Single	8GCM	L902688	8GCM-EP₄-L902688-Gi1/β1/γ2
8.33	Single	9B9Z	A1AKO	9B9Z-CB₁-A1AKO
8.33	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
7.69	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
7.69	Single	4JKV	Taladegib	4JKV-SMO-Taladegib
7.69	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
7.69	Single	6GPX	MK0812	6GPX-CCR2-MK0812
7.69	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
7.69	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/β1/γ2
7.69	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/β1/γ2
7.69	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/β1/γ2
7.69	Consensus	s1p5_off	Orthosteric Ligand	7YXA-S1P₅-ONO-5430608
7.14	Single	3PDS	Hydroxybenzylisoproterenol	3PDS-β₂-Hydroxybenzylisoproterenol
7.14	Single	5V56	TC114	5V56-SMO-TC114
7.14	Single	5V57	TC114	5V57-SMO-TC114
7.14	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
7.14	Single	7R0C	AVP	7R0C-V₂-AVP-Arrestin2
7.14	Single	8GDB	PGE2	8GDB-EP₄-PGE2-Gs/β1/γ2
7.14	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
7.14	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/β1/γ2
7.14	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
6.67	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
6.67	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
6.67	Single	6H7N	S-Xamoterol	6H7N-β₁-S-Xamoterol
6.67	Single	6IIU	Ramatroban	6IIU-TP-Ramatroban
6.67	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/β1/γ2
6.67	Single	8XJN	Cloprosetnol	8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Consensus	cannabinoid_off	Orthosteric Ligand	cb2_off cb1_off
6.67	Consensus	lipid_offon	Orthosteric Ligand	lipid_off lipid_on
6.67	Consensus	lipid_offon_gp	Orthosteric Ligand	lipid_on_gp lipid_off
6.25	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
6.25	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/β1/γ2
6.25	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/β1/γ1
6.25	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
6.25	Single	8XJK	Cloprosetnol	8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25	Single	8XJO	U46619	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25	Consensus	beta1_on	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
6.25	Consensus	beta1_on_gp	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
6.25	Consensus	fp-alpha_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25	Consensus	fp-alpha_on_gp	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25	Consensus	prostanoid_off	Orthosteric Ligand	ep_off dp_off
6.25	Consensus	prostanoid_on	Orthosteric Ligand	tp_on fp-alpha_on
6.25	Consensus	prostanoid_on_gp	Orthosteric Ligand	tp_on_gp fp-alpha_on_gp
6.25	Consensus	tp_on	Orthosteric Ligand	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25	Consensus	tp_on_gp	Orthosteric Ligand	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/β1/γ2
5.88	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/β1/γ2
5.88	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	4AMJ	S-Carvedilol	4AMJ-β₁-S-Carvedilol
5.56	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/β1/γ2
5.56	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/β1/γ2
5.56	Single	8FYL	Vilazodone	8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
4.76	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
4.76	Single	7KH0	AVP	7KH0-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.55	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/β1/γ2
4.55	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/β1/γ2
4.55	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
4.35	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
4.17	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
4.17	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Consensus	bk2_on	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
4.00	Consensus	bk2_on_gp	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
4.00	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on
4.00	Consensus	bradykinin_on_gp	Orthosteric Ligand	bk2_on_gp
4.00	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
3.70	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F96	R:R:L99	3.65	No	No	4	7	1	2
R:R:F96	W:W:?2	48.84	No	No	4	0	1	0
R:R:N100	W:W:?2	10.33	No	No	8	0	1	0
R:R:F103	W:W:?2	7.63	No	No	6	0	1	0
R:R:F103	R:R:W87	1	No	No	6	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
66.67	Single	8W8S	AA-14	8W8S-GPR101-AA-14
20.00	Single	8TLM	Anti-murine CCR8 antibody	8TLM-CCR8-Anti-murine CCR8 antibody
11.11	Single	8WKY	PG-934	8WKY-MC₄-PG-934
9.09	Single	4XNV	BPTU	4XNV-P2Y₁-BPTU
7.69	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
7.69	Single	8YIC	SAR247799	8YIC-S1P₁-SAR247799-Gi1/β1/γ2
7.69	Single	9IMA	Talquetamab	9IMA-GPRC5D-Talquetamab
6.67	Single	7XBD	Galanin	7XBD-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.45	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
6.45	Consensus	mc2_on_gp	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
6.25	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
6.25	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
6.25	Single	8XQN	Cholesterol	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
6.25	Consensus	galanin_on	Orthosteric Ligand	gal2_on gal1_on
6.25	Consensus	galanin_on_gp	Orthosteric Ligand	gal2_on_gp gal1_on_gp
6.25	Consensus	gi_p2y	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
6.25	Consensus	p2y12_on_gp	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
5.88	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
5.88	Single	8XWV	CXCL1	8XWV-CXCR2-CXCL1-Go/β1/γ2
5.88	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88	Consensus	gal2_on_gp	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56	Single	5VBL	Apelin mimetic peptide agonist	5VBL-Apelin-Apelin mimetic peptide agonist
5.56	Consensus	kiss1_on	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
5.56	Consensus	kisspeptin_on	Orthosteric Ligand	kiss1_on
5.26	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
5.26	Single	8KIG	SHU9119	8KIG-MC₃-SHU9119-Ca
5.26	Single	8ZJD	Kisspeptin-10	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
5.26	Consensus	gq_kisspeptin	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
5.26	Consensus	kiss1_on_gp	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
5.26	Consensus	kisspeptin_on_gp	Orthosteric Ligand	kiss1_on_gp
5.00	Single	8IOC	Gamma-MSH	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.00	Single	9EAI	Nanobody AT209	9EAI-AT₁-Losartan-Nanobody AT209
5.00	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
4.76	Single	7F4D	Alpha-MSH	7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2
4.76	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.76	Consensus	mc3_on_gp	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.55	Single	7DW9	AVP	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.55	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
4.55	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
4.55	Consensus	gs_vasop-oxy	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.55	Consensus	mc5_on_gp	Orthosteric Ligand	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
4.55	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.55	Consensus	v2_on_gp	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.55	Consensus	vasop-oxy_on	Orthosteric Ligand	v2_on
4.55	Consensus	vasop-oxy_on_gp	Orthosteric Ligand	v2_on_gp
4.35	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
4.35	Single	8XGO	TAK448	8XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
4.35	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
4.35	Consensus	mc1_on_gp	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
4.00	Single	7F53	Alpha-MSH	7F53-MC₄-α-MSH-Gs/β1/γ2
4.00	Single	8ZJG	Chemerin	8ZJG-CML1-Chemerin-Gi1/β1/γ2
3.85	Single	8Y52	BA1	8Y52-BB₃-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85	Consensus	etb_on	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
3.85	Consensus	gs_melanocortin	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2 8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2
3.70	Single	8ZJE	TAK-448	8ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
3.57	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/β1/γ2
3.57	Consensus	etb_on_gp	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
3.57	Consensus	melanocortin_on	Orthosteric Ligand	mc1_on mc4_on mc2_on mc3_on mc5_on
3.57	Consensus	melanocortin_on_gp	Orthosteric Ligand	mc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
3.45	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
2.63	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

PDB Summary
PDB	8W8R
Class	A
SubFamily	Orphan
Type	Orphan
SubType	GPR101
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	AA-14
Protein Partners	chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution	3.3
Date	2024-01-03
D.O.I.	10.1038/s41589-023-01456-6

Net Summary
I_min	2.69
Number of Linked Nodes	844
Number of Links	968
Number of Hubs	131
Number of Links mediated by Hubs	489
Number of Communities	39
Number of Nodes involved in Communities	196
Number of Links involved in Communities	254

Path Summary
Number Of Nodes in MetaPath	150
Number Of Links MetaPath	149
Number of Shortest Paths	786027
Length Of Smallest Path	3
Average Path Length	28.5858
Length of Longest Path	59
Minimum Path Strength	1.285
Average Path Strength	5.65941
Maximum Path Strength	29.585
Minimum Path Correlation	0.7
Average Path Correlation	0.976825
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.94118
Average % Of Corr. Nodes	45.8862
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.4835
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • D1 dopamine receptor binding • molecular function activator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase activator activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • establishment of protein localization • nitrogen compound transport • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • regulation of hormone secretion • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • receptor complex • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	U7D
PDB Residues	W:W:?1 W:W:?2
Environment Details	Open EMBL-EBI Page
Code	U7D
Name	1-(4-methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea
Synonyms	CHEMBL2134995
Identifier
Formula	C14 H12 F3 N3 S
Molecular Weight	311.325
SMILES
PubChem	848971
Formal Charge	0
Total Atoms	33
Total Chiral Atoms	0
Total Bonds	34
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	A
Protein	G Protein α Sub unit
UniProt	P63092
Sequence	>8W8R_Chain_A T L S A E D K A A V E R S K M I E K Q L Q K D K Q V Y R A T H R L L L L G A D N S G K S T I V K Q M R I Y V K T S G I F E T K F Q V D K V N F H M F D V G A Q R D E R R K W I Q C F N D V T A I I F V V D S S D Y N R L Q E A L N D F K S I W N N R W L R T I S V I L F L N K Q D L L A E K V L A G K S K I E D Y F P E F A R Y T T P E D A T P E P G E D P R V T R A K Y F I R D E F L R I S T A S G D G R H Y C Y P H F T C S V D T E N A R R I F N D C R D I I Q R M H L R Q Y E L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	B
Protein	G Protein β Sub unit
UniProt	P62873
Sequence	>8W8R_Chain_B Q L R Q E A E Q L K N Q I R D A R K A C A D A T L S Q I T N N I D P V G R I Q M R T R R T L R G H L A K I Y A M H W G T D S R L L V S A S Q D G K L I I W D S Y T T N K V H A I P L R S S W V M T C A Y A P S G N Y V A C G G L D N I C S I Y N L K T R E G N V R V S R E L A G H T G Y L S C C R F L D D N Q I V T S S G D T T C A L W D I E T G Q Q T T T F T G H T G D V M S L S L A P D T R L F V S G A C D A S A K L W D V R E G M C R Q T F T G H E S D I N A I C F F P N G N A F A T G S D D A T C R L F D L R A D Q E L M T Y S H D N I I C G I T S V S F S K S G R L L L A G Y D D F N C N V W D A L K A D R A G V L A G H D N R V S C L G V T D D G M A V A T G S W D S F L K I W N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	G
Protein	G Protein γ Sub unit
UniProt	P59768
Sequence	>8W8R_Chain_G N T A S I A Q A R K L V E Q L K M E A N I D R I K V S K A A A D L M A Y C E A H A K E D P L L T P V P A S E N P F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	Q96P66
Sequence	>8W8R_Chain_R L A H G I I R S T V L V I F L A A S F V G N I V L A L V L Q R K P Q L L Q V T N R F I F N L L V T D L L Q I S L V A P W V V A T S V P L F W P L N S H F C T A L V S L T H L F A F A S V N T I V V V S V D R Y L S I I H P L S Y P S K M T Q R R G Y L L L Y G T W I V A I L Q S T P P L Y G W G Q A A F D E R N A L C S M I W G A S P S Y T I L S V V S F I V I P L I V M I A C Y S V V F C A A R R Q H A L L Y N C K A A K V I F I I I F S Y V L S L G P Y C F L A V L A V W V D V E T Q V P Q W V I T I I I W L F F L Q C C I H P Y V Y G Y M H K T I K K E I Q D M L K K F F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8W8S	A	Orphan	Orphan	GPR101	Homo sapiens	-	AA-14	-	3.3	2024-01-03	10.1038/s41589-023-01456-6
	8W8R	A	Orphan	Orphan	GPR101	Homo sapiens	-	AA-14	chim(NtGi1-Gs)/β1/γ2	3.3	2024-01-03	10.1038/s41589-023-01456-6
	8W8R (No Gprot)	A	Orphan	Orphan	GPR101	Homo sapiens	-	AA-14		3.3	2024-01-03	10.1038/s41589-023-01456-6
	8W8Q	A	Orphan	Orphan	GPR101	Homo sapiens	-	-	Gs/β1/γ2	2.89	2024-01-03	10.1038/s41589-023-01456-6
	8W8Q (No Gprot)	A	Orphan	Orphan	GPR101	Homo sapiens	-	-		2.89	2024-01-03	10.1038/s41589-023-01456-6

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