psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	S:S:I360	S:S:N41	4.25	No	No	0	3	5
2	S:S:R44	S:S:S42	5.27	No	No	0	4	3
3	S:S:I43	S:S:N359	4.25	No	Yes	3	4	7
4	S:S:I43	S:S:W361	5.87	No	Yes	3	4	5
5	S:S:R104	S:S:R44	17.06	No	No	0	5	4
6	S:S:A103	S:S:I45	4.87	No	No	0	7	4
7	S:S:I45	S:S:R358	3.76	No	Yes	0	4	4
8	S:S:D48	S:S:I99	5.6	No	Yes	0	8	5
9	S:S:D48	S:S:L434	10.86	No	No	0	8	3
10	S:S:I49	S:S:I99	4.42	No	Yes	0	6	5
11	S:S:I49	S:S:V151	4.61	No	Yes	0	6	4
12	S:S:G102	S:S:T50	3.64	No	No	0	9	4
13	S:S:L101	S:S:L51	4.15	Yes	No	0	9	7
14	S:S:L51	S:S:M416	4.24	No	Yes	0	7	6
15	S:S:L54	S:S:T108	4.42	No	No	0	6	6
16	S:S:F122	S:S:L54	4.87	Yes	No	0	5	6
17	S:S:L54	S:S:V165	4.47	No	No	0	6	5
18	S:S:F55	S:S:L79	7.31	Yes	No	2	9	5
19	S:S:F55	S:S:M82	4.98	Yes	Yes	2	9	8
20	S:S:F55	S:S:I105	6.28	Yes	No	2	9	8
21	S:S:F55	S:S:Y179	10.32	Yes	Yes	2	9	8
22	S:S:K71	S:S:P56	10.04	No	No	0	5	5
23	S:S:G75	S:S:P56	4.06	No	No	0	5	5
24	S:S:P56	S:S:S157	7.13	No	Yes	0	5	5
25	S:S:H58	S:S:V57	6.92	Yes	No	3	8	6
26	S:S:D107	S:S:V57	10.22	Yes	No	3	9	6
27	S:S:V57	S:S:W361	18.39	No	Yes	3	6	5
28	S:S:D107	S:S:H58	8.82	Yes	Yes	3	9	8
29	S:S:C109	S:S:H58	4.42	Yes	Yes	3	7	8
30	S:S:H58	S:S:W361	4.23	Yes	Yes	3	8	5
31	S:S:E364	S:S:H58	3.69	Yes	Yes	3	5	8
32	S:S:G59	S:S:S110	3.71	No	No	0	3	4
33	S:S:R60	S:S:S110	3.95	No	No	0	2	4
34	S:S:R111	S:S:R60	11.73	No	No	0	5	2
35	S:S:K65	S:S:P66	6.69	No	No	0	1	1
36	S:S:C109	S:S:P66	3.77	Yes	No	0	7	1
37	S:S:P66	S:S:R111	7.21	No	No	0	1	5
38	S:S:E364	S:S:L70	5.3	Yes	No	0	5	5
39	S:S:D368	S:S:L70	5.43	No	No	0	3	5
40	S:S:K71	S:S:K74	10.06	No	Yes	0	5	5
41	S:S:F365	S:S:K72	7.44	No	No	0	6	4
42	S:S:D368	S:S:K72	13.83	No	No	0	3	4
43	S:S:A319	S:S:E73	6.03	No	No	0	1	2
44	S:S:K74	S:S:R78	14.85	Yes	Yes	2	5	4
45	S:S:E287	S:S:K74	13.5	Yes	Yes	0	3	5
46	S:S:E403	S:S:K74	8.1	Yes	Yes	2	5	5
47	M:M:?1	S:S:K74	10.77	Yes	Yes	2	0	5
48	S:S:F365	S:S:I76	15.07	No	No	0	6	5
49	S:S:R78	S:S:S157	3.95	Yes	Yes	2	4	5
50	S:S:R78	S:S:Y179	9.26	Yes	Yes	2	4	8
51	S:S:A180	S:S:R78	4.15	No	Yes	2	6	4
52	S:S:E403	S:S:R78	13.96	Yes	Yes	2	5	4
53	S:S:K405	S:S:R78	9.9	Yes	Yes	2	4	4
54	S:S:R78	S:S:V409	3.92	Yes	No	2	4	7
55	M:M:?1	S:S:R78	10.31	Yes	Yes	2	0	4
56	S:S:I105	S:S:L79	8.56	No	No	2	8	5
57	S:S:E80	S:S:F348	7	No	No	0	8	7
58	S:S:E80	S:S:N359	7.89	No	Yes	3	8	7
59	S:S:E80	S:S:F362	7	No	Yes	3	8	5
60	S:S:A81	S:S:F344	4.16	No	Yes	0	7	8
61	S:S:L86	S:S:M82	4.24	No	Yes	0	7	8
62	S:S:I105	S:S:M82	5.83	No	Yes	2	8	8
63	S:S:I154	S:S:M82	4.37	No	Yes	0	8	8
64	S:S:L83	S:S:R358	7.29	No	Yes	0	5	4
65	S:S:F84	S:S:G343	4.52	No	No	0	7	5
66	S:S:F84	S:S:Y347	15.47	No	No	0	7	7
67	S:S:A85	S:S:I410	4.87	No	No	0	8	7
68	S:S:A85	S:S:V413	5.09	No	No	0	8	9
69	S:S:L101	S:S:L86	4.15	Yes	No	0	9	7
70	S:S:D87	S:S:R358	10.72	No	Yes	0	7	4
71	S:S:R88	S:S:Y414	9.26	No	No	0	8	8
72	S:S:I89	S:S:L101	7.14	No	Yes	0	9	9
73	S:S:N90	S:S:T100	8.77	No	No	0	9	7
74	S:S:L101	S:S:N90	8.24	Yes	No	0	9	9
75	S:S:D92	S:S:P93	6.44	No	No	0	7	3
76	S:S:D92	S:S:L95	6.79	No	No	0	7	7
77	S:S:D94	S:S:H421	3.78	No	No	0	3	7
78	S:S:H418	S:S:L95	6.43	No	No	0	6	7
79	S:S:I99	S:S:L96	11.42	Yes	No	0	5	9
80	S:S:L101	S:S:L96	4.15	Yes	No	0	9	9
81	S:S:L420	S:S:L96	6.92	No	No	0	8	9
82	S:S:H421	S:S:P97	6.1	No	No	0	7	8
83	S:S:N98	S:S:V432	4.43	No	No	0	8	3
84	S:S:H424	S:S:I99	3.98	No	Yes	0	5	5
85	S:S:F122	S:S:R104	4.28	Yes	No	0	5	5
86	S:S:L106	S:S:Q118	17.3	No	No	0	5	5
87	S:S:F122	S:S:L106	7.31	Yes	No	0	5	5
88	S:S:C109	S:S:D107	6.22	Yes	Yes	3	7	9
89	S:S:D107	S:S:W361	4.47	Yes	Yes	3	9	5
90	S:S:T108	S:S:V161	4.76	No	Yes	0	6	4
91	S:S:C109	S:S:H114	7.37	Yes	No	0	7	3
92	S:S:E259	S:S:R111	5.82	No	No	0	3	5
93	S:S:D112	S:S:V161	5.84	No	Yes	0	4	4
94	S:S:D112	S:S:M164	19.41	No	Yes	0	4	5
95	R:R:R170	S:S:T113	5.17	No	No	0	5	3
96	S:S:E117	S:S:H114	3.69	No	No	0	4	3
97	S:S:H114	S:S:Q118	12.36	No	No	0	3	5
98	S:S:A115	S:S:V161	5.09	No	Yes	0	7	4
99	S:S:L116	S:S:M164	4.24	Yes	Yes	11	5	5
100	R:R:N167	S:S:L116	5.49	No	Yes	11	5	5
101	R:R:I168	S:S:L116	5.71	No	Yes	11	5	5
102	R:R:L171	S:S:L116	4.15	Yes	Yes	0	5	5
103	R:R:L171	S:S:E117	6.63	Yes	No	0	5	4
104	S:S:I168	S:S:S119	4.64	Yes	No	0	5	6
105	S:S:L169	S:S:S119	4.5	No	No	0	6	6
106	R:R:L171	S:S:L120	5.54	Yes	No	0	5	5
107	R:R:F172	S:S:L120	8.53	No	No	0	6	5
108	S:S:F122	S:S:V153	3.93	Yes	No	0	5	6
109	S:S:F172	S:S:V123	18.35	No	No	0	6	5
110	S:S:R149	S:S:V151	5.23	No	Yes	28	3	4
111	S:S:R149	S:S:V441	9.15	No	No	28	3	3
112	S:S:L420	S:S:V151	4.47	No	Yes	0	8	4
113	S:S:V151	S:S:V441	6.41	Yes	No	28	4	3
114	S:S:G155	S:S:Q176	4.93	No	Yes	0	8	8
115	S:S:G155	S:S:S178	3.71	No	No	0	8	9
116	S:S:G158	S:S:S157	3.71	No	Yes	0	4	5
117	S:S:S157	S:S:Y179	3.82	Yes	Yes	2	5	8
118	S:S:S159	S:S:S181	4.89	No	No	0	9	8
119	S:S:S159	S:S:Y230	5.09	No	Yes	2	9	7
120	M:M:?1	S:S:S159	3.82	Yes	No	2	0	9
121	S:S:Q176	S:S:S162	4.33	Yes	No	7	8	7
122	S:S:S162	S:S:S181	6.52	No	No	0	7	8
123	S:S:F195	S:S:S162	6.61	Yes	No	7	8	7
124	S:S:D185	S:S:I163	4.2	Yes	No	7	4	6
125	S:S:I163	S:S:L186	5.71	No	No	7	6	8
126	S:S:I163	S:S:Y192	10.88	No	Yes	0	6	5
127	S:S:M164	S:S:N167	4.21	Yes	Yes	11	5	5
128	R:R:N167	S:S:M164	11.22	No	Yes	11	5	5
129	S:S:Q176	S:S:V165	7.16	Yes	No	0	8	5
130	S:S:A166	S:S:Q176	4.55	No	Yes	0	7	8
131	S:S:A166	S:S:Y192	4	No	Yes	0	7	5
132	S:S:I168	S:S:N167	4.25	Yes	Yes	11	5	5
133	S:S:N167	S:S:Y192	4.65	Yes	Yes	0	5	5
134	R:R:L116	S:S:N167	4.12	Yes	Yes	11	5	5
135	R:R:M164	S:S:N167	7.01	Yes	Yes	11	5	5
136	R:R:L116	S:S:I168	4.28	Yes	Yes	11	5	5
137	R:R:I168	S:S:I168	4.42	No	Yes	11	5	5
138	S:S:I174	S:S:L169	11.42	No	No	0	6	6
139	S:S:L171	S:S:R170	3.64	No	Yes	0	5	5
140	S:S:D193	S:S:R170	4.76	No	Yes	0	6	5
141	R:R:T113	S:S:R170	6.47	No	Yes	0	3	5
142	R:R:E117	S:S:R170	5.82	No	Yes	0	4	5
143	R:R:L116	S:S:L171	8.3	Yes	No	0	5	5
144	R:R:L120	S:S:L171	6.92	No	No	0	5	5
145	S:S:F194	S:S:K173	9.93	No	No	0	7	4
146	S:S:L446	S:S:P175	8.21	No	No	0	6	8
147	S:S:F195	S:S:Q176	8.2	Yes	Yes	7	8	8
148	S:S:I177	S:S:M416	7.29	No	Yes	0	7	6
149	S:S:I177	S:S:I450	7.36	No	Yes	0	7	7
150	S:S:S178	S:S:S181	4.89	No	No	0	9	8
151	S:S:F195	S:S:S178	5.28	Yes	No	0	8	9
152	S:S:V409	S:S:Y179	8.83	No	Yes	2	7	8
153	S:S:A180	S:S:K405	6.42	No	Yes	2	6	4
154	M:M:?1	S:S:A180	5.35	Yes	No	2	0	6
155	S:S:D202	S:S:T182	10.12	Yes	No	2	8	8
156	S:S:Q205	S:S:T182	5.67	Yes	No	2	9	8
157	S:S:D312	S:S:T182	7.23	Yes	No	2	8	8
158	S:S:A183	S:S:D185	4.63	No	Yes	0	7	4
159	S:S:P184	S:S:S201	5.34	No	No	0	5	8
160	S:S:D202	S:S:P184	4.83	Yes	No	0	8	5
161	S:S:P184	S:S:S233	7.13	No	No	0	5	4
162	S:S:D185	S:S:L186	5.43	Yes	No	7	4	8
163	S:S:D185	S:S:S229	7.36	Yes	No	0	4	6
164	S:S:F195	S:S:L186	13.4	Yes	No	7	8	8
165	S:S:R197	S:S:S187	6.59	Yes	No	7	9	8
166	S:S:D470	S:S:S187	8.83	Yes	No	7	7	8
167	S:S:D188	S:S:S190	4.42	No	No	0	6	2
168	S:S:D188	S:S:R191	4.76	No	Yes	0	6	5
169	S:S:D193	S:S:N189	5.39	No	No	0	6	7
170	S:S:N189	S:S:R451	7.23	No	Yes	0	7	6
171	R:R:E259	S:S:S190	5.75	No	No	0	3	2
172	S:S:R191	S:S:Y192	20.58	Yes	Yes	0	5	5
173	R:R:D112	S:S:R191	10.72	Yes	Yes	11	4	5
174	R:R:M164	S:S:R191	3.72	Yes	Yes	11	5	5
175	R:R:R258	S:S:R191	9.6	No	Yes	0	4	5
176	S:S:F194	S:S:L447	9.74	No	No	0	7	6
177	S:S:F195	S:S:R197	12.83	Yes	Yes	7	8	9
178	S:S:I450	S:S:S196	4.64	Yes	No	29	7	6
179	S:S:R451	S:S:S196	6.59	Yes	No	0	6	6
180	S:S:F465	S:S:S196	6.61	No	No	29	8	6
181	S:S:R197	S:S:V199	3.92	Yes	No	0	9	7
182	S:S:R197	S:S:S201	3.95	Yes	No	0	9	8
183	S:S:D470	S:S:R197	10.72	Yes	Yes	7	7	9
184	S:S:D411	S:S:V198	5.84	No	No	0	8	9
185	S:S:F408	S:S:V199	7.87	Yes	No	0	7	7
186	S:S:A471	S:S:P200	3.74	No	No	0	4	7
187	S:S:G473	S:S:P200	4.06	No	No	0	5	7
188	S:S:P200	S:S:Y475	9.74	No	Yes	0	7	8
189	S:S:S201	S:S:T203	7.99	No	No	0	8	3
190	S:S:D202	S:S:Q205	13.05	Yes	Yes	2	8	9
191	S:S:D202	S:S:Y230	6.9	Yes	Yes	2	8	7
192	S:S:T203	S:S:Y204	6.24	No	Yes	0	3	4
193	S:S:G473	S:S:Y204	4.35	No	Yes	0	5	4
194	S:S:Y204	S:S:Y475	3.97	Yes	Yes	0	4	8
195	S:S:W495	S:S:Y204	3.86	Yes	Yes	0	5	4
196	S:S:D312	S:S:Q205	11.75	Yes	Yes	2	8	9
197	S:S:Q205	S:S:Y475	12.4	Yes	Yes	0	9	8
198	S:S:Q207	S:S:V210	4.3	Yes	Yes	0	4	6
199	S:S:D211	S:S:Q207	7.83	No	Yes	16	5	4
200	S:S:K241	S:S:Q207	12.2	No	Yes	0	5	4
201	S:S:Q207	S:S:W495	4.38	Yes	Yes	16	4	5
202	S:S:A208	S:S:W495	10.37	No	Yes	0	7	5
203	S:S:F238	S:S:M209	3.73	No	No	0	7	7
204	S:S:F284	S:S:M209	6.22	Yes	No	0	8	7
205	S:S:R214	S:S:V210	7.85	No	Yes	0	4	6
206	S:S:F238	S:S:V210	3.93	No	Yes	0	7	6
207	S:S:D211	S:S:W495	6.7	No	Yes	16	5	5
208	S:S:D211	S:S:L499	4.07	No	Yes	16	5	7
209	S:S:I212	S:S:I477	8.83	No	No	0	8	7
210	S:S:I212	S:S:L499	7.14	No	Yes	16	8	7
211	S:S:I212	S:S:L501	5.71	No	Yes	16	8	7
212	S:S:V213	S:S:W218	7.36	No	Yes	0	6	9
213	S:S:D245	S:S:R214	14.29	No	No	0	4	4
214	S:S:G246	S:S:R214	7.51	No	No	0	7	4
215	S:S:L216	S:S:W218	15.94	No	Yes	0	8	9
216	S:S:L216	S:S:M506	4.24	No	No	0	8	7
217	S:S:A280	S:S:W218	5.19	No	Yes	0	8	9
218	S:S:F307	S:S:W218	9.02	No	Yes	0	7	9
219	S:S:S518	S:S:W218	12.36	No	Yes	0	9	9
220	S:S:I519	S:S:N219	8.5	No	No	0	5	6
221	S:S:A251	S:S:Y220	8.01	No	Yes	0	8	9
222	S:S:C520	S:S:Y220	14.79	No	Yes	30	9	9
223	S:S:C539	S:S:Y220	4.03	No	Yes	30	9	9
224	S:S:I282	S:S:V221	4.61	No	No	0	7	7
225	S:S:L272	S:S:S222	4.5	Yes	No	20	8	8
226	S:S:S222	S:S:V281	8.08	No	Yes	20	8	6
227	S:S:I250	S:S:T223	7.6	No	No	0	6	5
228	S:S:V224	S:S:V254	4.81	No	No	0	5	5
229	S:S:L272	S:S:V224	4.47	Yes	No	0	8	5
230	S:S:I283	S:S:V224	4.61	No	No	0	5	5
231	S:S:A225	S:S:V235	5.09	No	No	0	5	5
232	S:S:I256	S:S:S226	4.64	Yes	No	0	5	7
233	S:S:E227	S:S:K255	10.8	No	No	0	7	4
234	S:S:E227	S:S:R258	5.82	No	No	0	7	4
235	S:S:G228	S:S:R258	4.5	No	No	0	6	4
236	S:S:G231	S:S:Y230	4.35	No	Yes	0	8	7
237	S:S:S311	S:S:Y230	3.82	No	Yes	0	8	7
238	S:S:S313	S:S:Y230	3.82	No	Yes	2	6	7
239	M:M:?1	S:S:Y230	26.87	Yes	Yes	2	0	7
240	S:S:E232	S:S:K255	12.15	No	No	0	5	4
241	S:S:G234	S:S:S233	3.71	No	No	0	7	4
242	S:S:F284	S:S:G234	6.02	Yes	No	0	8	7
243	S:S:F284	S:S:V235	5.24	Yes	No	0	8	5
244	S:S:E236	S:S:Q240	12.74	No	No	0	5	4
245	S:S:F238	S:S:I282	5.02	No	No	0	7	7
246	R:R:R271	S:S:R243	17.06	No	No	0	3	3
247	S:S:C249	S:S:M536	9.73	No	No	0	9	6
248	S:S:C249	S:S:C538	5.46	No	No	0	9	9
249	S:S:E274	S:S:Q252	11.47	No	No	0	4	6
250	S:S:I268	S:S:V254	6.14	No	No	0	5	5
251	S:S:R271	S:S:V254	6.54	No	No	0	3	5
252	R:R:E236	S:S:K255	6.75	No	No	0	5	4
253	S:S:F265	S:S:I256	3.77	Yes	Yes	21	4	5
254	S:S:I256	S:S:I268	5.89	Yes	No	0	5	5
255	S:S:D289	S:S:I256	7	Yes	Yes	21	4	5
256	S:S:E264	S:S:P257	11	No	No	0	3	4
257	R:R:R191	S:S:R258	6.4	No	No	0	5	4
258	S:S:E259	S:S:K261	4.05	No	No	0	3	3
259	S:S:F265	S:S:P260	7.22	Yes	No	21	4	2
260	S:S:P260	S:S:R292	12.97	No	No	21	2	1
261	S:S:D266	S:S:G263	5.03	No	No	0	3	1
262	S:S:D289	S:S:F265	4.78	Yes	Yes	21	4	4
263	S:S:F265	S:S:R292	22.45	Yes	No	21	4	1
264	S:S:F265	S:S:V293	5.24	Yes	No	0	4	5
265	S:S:D266	S:S:R270	4.76	No	No	0	3	1
266	S:S:K267	S:S:R270	8.66	No	No	0	2	1
267	S:S:F306	S:S:I269	3.77	Yes	Yes	0	7	4
268	R:R:R243	S:S:R271	15.99	No	No	0	3	3
269	S:S:L272	S:S:V281	4.47	Yes	Yes	20	8	6
270	S:S:F306	S:S:L272	3.65	Yes	Yes	20	7	8
271	S:S:L273	S:S:Q302	11.98	No	No	0	5	4
272	S:S:F306	S:S:L273	4.87	Yes	No	0	7	5
273	S:S:H305	S:S:R279	6.77	Yes	No	0	3	6
274	S:S:F307	S:S:R279	9.62	No	No	0	7	6
275	S:S:F306	S:S:V281	3.93	Yes	Yes	20	7	6
276	S:S:V281	S:S:W308	4.9	Yes	Yes	20	6	7
277	S:S:I282	S:S:M309	4.37	No	No	0	7	6
278	S:S:I283	S:S:W308	4.7	No	Yes	0	5	7
279	S:S:I283	S:S:W314	5.87	No	Yes	0	5	7
280	S:S:F284	S:S:S311	7.93	Yes	No	0	8	8
281	S:S:A285	S:S:D289	4.63	No	Yes	0	4	4
282	S:S:D289	S:S:N286	5.39	Yes	No	0	4	5
283	S:S:E287	S:S:S313	4.31	Yes	No	0	3	6
284	S:S:E287	S:S:K317	5.4	Yes	No	0	3	6
285	S:S:E287	S:S:P320	9.43	Yes	No	0	3	5
286	S:S:D288	S:S:R292	11.91	No	No	0	1	1
287	S:S:I290	S:S:W314	16.44	No	Yes	0	4	7
288	S:S:L322	S:S:R291	3.64	No	No	0	3	1
289	S:S:H323	S:S:R291	14.67	Yes	No	0	1	1
290	S:S:H323	S:S:L294	9	Yes	No	0	1	5
291	S:S:L294	S:S:V327	4.47	No	No	0	5	3
292	S:S:E295	S:S:R298	11.63	No	Yes	31	2	3
293	S:S:E295	S:S:H323	11.08	No	Yes	31	2	1
294	S:S:A296	S:S:R299	4.15	No	No	0	5	3
295	S:S:H323	S:S:R298	12.41	Yes	Yes	31	1	3
296	S:S:E326	S:S:R298	4.65	No	Yes	0	3	3
297	S:S:R298	S:S:V327	9.15	Yes	No	0	3	3
298	S:S:H305	S:S:Q302	12.36	Yes	No	0	3	4
299	S:S:E329	S:S:T303	4.23	Yes	No	0	5	6
300	S:S:E329	S:S:G304	6.55	Yes	No	0	5	3
301	S:S:F306	S:S:H305	11.31	Yes	Yes	0	7	3
302	S:S:F306	S:S:W308	9.02	Yes	Yes	20	7	7
303	S:S:F307	S:S:P516	5.78	No	No	0	7	8
304	S:S:M309	S:S:V332	6.09	No	No	0	6	5
305	S:S:G310	S:S:W314	7.04	No	Yes	0	7	7
306	S:S:D312	S:S:P336	9.66	Yes	Yes	0	8	5
307	S:S:D312	S:S:K405	11.06	Yes	Yes	2	8	4
308	M:M:?1	S:S:S313	10.2	Yes	No	2	0	6
309	S:S:P320	S:S:W314	8.11	No	Yes	0	5	7
310	S:S:G315	S:S:L335	6.84	No	No	0	5	5
311	S:S:S316	S:S:Y489	11.45	No	Yes	0	5	5
312	S:S:E403	S:S:K317	5.4	Yes	No	0	5	6
313	S:S:V321	S:S:Y480	17.66	No	No	32	4	6
314	S:S:V321	S:S:Y489	5.05	No	Yes	32	4	5
315	S:S:E326	S:S:L324	11.93	No	No	0	3	4
316	S:S:E325	S:S:E326	3.81	No	No	0	4	3
317	S:S:E325	S:S:E329	5.07	No	Yes	0	4	5
318	S:S:E325	S:S:L482	14.58	No	No	0	4	3
319	S:S:E329	S:S:W508	4.36	Yes	No	0	5	8
320	S:S:G330	S:S:Q479	4.93	No	Yes	0	8	8
321	S:S:T333	S:S:Y489	6.24	No	Yes	0	7	5
322	S:S:I334	S:S:Y475	7.25	No	Yes	0	7	8
323	S:S:L335	S:S:P336	4.93	No	Yes	0	5	5
324	S:S:F408	S:S:P336	5.78	Yes	Yes	0	7	5
325	S:S:P336	S:S:Y475	9.74	Yes	Yes	0	5	8
326	S:S:K337	S:S:R474	7.43	Yes	No	0	5	4
327	S:S:D476	S:S:K337	15.21	No	Yes	0	8	5
328	S:S:K337	S:S:S494	4.59	Yes	No	0	5	3
329	S:S:G404	S:S:R338	9.01	No	No	0	5	5
330	S:S:A459	S:S:M339	4.83	No	No	0	4	3
331	S:S:Q402	S:S:S340	8.66	Yes	No	0	6	3
332	S:S:F344	S:S:V341	3.93	Yes	No	0	8	6
333	S:S:I458	S:S:V341	4.61	No	No	0	3	6
334	S:S:G343	S:S:R346	7.51	No	No	0	5	3
335	S:S:F344	S:S:F348	6.43	Yes	No	0	8	7
336	S:S:F344	S:S:Q402	7.03	Yes	Yes	0	8	6
337	S:S:D345	S:S:Y400	5.75	No	No	0	4	5
338	S:S:D345	S:S:Q402	5.22	No	Yes	0	4	6
339	S:S:R351	S:S:Y347	21.61	Yes	No	0	5	7
340	S:S:R358	S:S:Y347	5.14	Yes	No	0	4	7
341	S:S:F348	S:S:Y400	7.22	No	No	0	7	5
342	S:S:R351	S:S:S350	3.95	Yes	No	0	5	4
343	S:S:N355	S:S:R351	8.44	No	Yes	0	4	5
344	S:S:N356	S:S:R351	6.03	No	Yes	0	4	5
345	S:S:N355	S:S:T352	4.39	No	No	0	4	4
346	S:S:L353	S:S:W366	6.83	No	Yes	0	6	6
347	S:S:N359	S:S:W361	4.52	Yes	Yes	3	7	5
348	S:S:F362	S:S:N359	7.25	Yes	Yes	3	5	7
349	S:S:I360	S:S:W361	8.22	No	Yes	0	3	5
350	S:S:E364	S:S:W361	9.81	Yes	Yes	3	5	5
351	S:S:F362	S:S:F365	7.5	Yes	No	0	5	6
352	S:S:F362	S:S:W366	5.01	Yes	Yes	3	5	6
353	S:S:F370	S:S:W366	10.02	Yes	Yes	3	8	6
354	S:S:E392	S:S:W366	14.17	Yes	Yes	3	7	6
355	S:S:I394	S:S:W366	7.05	Yes	Yes	3	5	6
356	S:S:E367	S:S:K373	8.1	No	No	0	6	4
357	S:S:F370	S:S:N369	21.75	Yes	No	3	8	3
358	S:S:N369	S:S:S398	8.94	No	No	3	3	3
359	S:S:E392	S:S:F370	19.82	Yes	Yes	3	7	8
360	S:S:F370	S:S:I394	3.77	Yes	Yes	3	8	5
361	S:S:D397	S:S:F370	7.17	No	Yes	0	3	8
362	S:S:F370	S:S:S398	3.96	Yes	No	3	8	3
363	S:S:C372	S:S:C388	7.28	No	No	0	8	8
364	S:S:C388	S:S:E392	6.08	No	Yes	0	8	7
365	S:S:I394	S:S:R393	8.77	Yes	No	0	5	4
366	S:S:Q402	S:S:V406	5.73	Yes	No	0	6	6
367	S:S:E403	S:S:G404	4.91	Yes	No	0	5	5
368	S:S:E403	S:S:K405	8.1	Yes	Yes	2	5	4
369	S:S:F408	S:S:K405	4.96	Yes	Yes	0	7	4
370	M:M:?1	S:S:K405	7.18	Yes	Yes	2	0	4
371	S:S:F408	S:S:Q407	8.2	Yes	No	0	7	7
372	S:S:I458	S:S:Q407	4.12	No	No	0	3	7
373	S:S:N461	S:S:Q407	3.96	Yes	No	0	5	7
374	S:S:D411	S:S:V463	11.69	No	No	0	8	6
375	S:S:F455	S:S:Y414	5.16	Yes	No	0	9	8
376	S:S:F455	S:S:H418	23.76	Yes	No	0	9	6
377	S:S:H421	S:S:R425	6.77	No	No	0	7	3
378	S:S:L446	S:S:M423	4.24	No	No	0	6	6
379	S:S:M423	S:S:Y449	8.38	No	Yes	0	6	4
380	S:S:C428	S:S:H424	5.9	No	No	0	7	5
381	S:S:D426	S:S:Y449	8.05	No	Yes	0	4	4
382	S:S:L427	S:S:M438	4.24	No	No	0	3	4
383	S:S:L427	S:S:Q445	6.65	No	No	0	3	6
384	S:S:C428	S:S:C435	7.28	No	No	0	7	6
385	S:S:C428	S:S:M438	4.86	No	No	0	7	4
386	S:S:P429	S:S:R431	4.32	No	No	0	2	3
387	S:S:C435	S:S:P429	3.77	No	No	0	6	2
388	S:S:L434	S:S:M438	7.07	No	No	0	3	4
389	S:S:D439	S:S:P440	8.05	No	No	0	1	3
390	S:S:D442	S:S:T444	5.78	No	No	0	4	3
391	S:S:Q445	S:S:Y449	4.51	No	Yes	0	6	4
392	S:S:I450	S:S:L446	5.71	Yes	No	0	7	6
393	S:S:L447	S:S:R451	3.64	No	Yes	0	6	6
394	S:S:K448	S:S:N452	9.79	No	No	0	3	4
395	S:S:F465	S:S:I450	3.77	No	Yes	29	8	7
396	S:S:G469	S:S:R451	6	No	Yes	0	7	6
397	S:S:F455	S:S:V463	10.49	Yes	No	0	9	6
398	S:S:N466	S:S:N468	5.45	No	No	7	7	7
399	S:S:D470	S:S:N466	5.39	Yes	No	7	7	7
400	S:S:D470	S:S:N468	4.04	Yes	No	7	7	7
401	S:S:P472	S:S:R474	7.21	No	No	0	3	4
402	S:S:D476	S:S:Y478	9.2	No	No	0	8	4
403	S:S:V491	S:S:Y478	6.31	No	No	0	5	4
404	S:S:Q479	S:S:Q481	6.4	Yes	No	0	8	7
405	S:S:H507	S:S:Q479	7.42	No	Yes	0	4	8
406	S:S:Y480	S:S:Y489	7.94	No	Yes	32	6	5
407	S:S:Q481	S:S:R483	7.01	No	No	0	7	3
408	S:S:Q481	S:S:W508	9.86	No	No	0	7	8
409	S:S:E488	S:S:R483	6.98	No	No	0	4	3
410	S:S:E488	S:S:S486	4.31	No	No	0	4	4
411	S:S:K490	S:S:R505	8.66	No	No	0	5	3
412	S:S:L499	S:S:W495	6.83	Yes	Yes	16	7	5
413	S:S:D497	S:S:T496	5.78	No	No	0	2	5
414	S:S:D497	S:S:H498	13.87	No	No	0	2	4
415	S:S:H498	S:S:H500	13.14	No	No	0	4	1
416	S:S:L499	S:S:L501	4.15	Yes	Yes	16	7	7
417	S:S:L501	S:S:M506	7.07	Yes	No	0	7	7
418	S:S:E504	S:S:R502	8.14	No	No	33	3	5
419	S:S:R502	S:S:R505	8.53	No	No	33	5	3
420	S:S:E504	S:S:R505	5.82	No	No	33	3	3
421	S:S:H507	S:S:P516	15.25	No	No	0	4	8
422	S:S:L515	S:S:P516	4.93	No	No	0	4	8
423	S:S:C520	S:S:C539	7.28	No	No	30	9	9
424	S:S:C524	S:S:C542	7.28	No	No	0	9	9
425	S:S:P526	S:S:Q525	4.74	No	Yes	24	6	1
426	S:S:E528	S:S:Q525	14.02	Yes	Yes	24	5	1
427	S:S:Q525	S:S:R529	8.18	Yes	Yes	24	1	6
428	S:S:E528	S:S:P526	14.15	Yes	No	24	5	6
429	S:S:G527	S:S:Q551	4.93	No	No	0	9	8
430	S:S:E528	S:S:R529	4.65	Yes	Yes	24	5	6
431	S:S:E528	S:S:N569	5.26	Yes	No	0	5	4
432	S:S:P544	S:S:R529	7.21	No	Yes	0	4	6
433	S:S:R529	S:S:R570	11.73	Yes	No	0	6	6
434	S:S:K530	S:S:T532	4.5	No	No	0	8	3
435	S:S:E543	S:S:K530	5.4	No	No	0	4	8
436	S:S:C545	S:S:K530	4.85	No	No	0	9	8
437	S:S:K531	S:S:R554	8.66	No	No	0	6	7
438	S:S:H541	S:S:T532	4.11	No	No	0	6	3
439	S:S:E543	S:S:P544	7.86	No	No	0	4	4
440	S:S:C545	S:S:Q549	4.58	No	Yes	34	9	7
441	S:S:C545	S:S:C557	7.28	No	No	34	9	9
442	S:S:G547	S:S:T546	5.46	No	No	0	5	5
443	S:S:Q549	S:S:T546	4.25	Yes	No	0	7	5
444	S:S:G547	S:S:R570	6	No	No	0	5	6
445	S:S:T559	S:S:Y548	6.24	No	No	0	3	8
446	S:S:Q732	S:S:Y548	5.64	No	No	0	6	8
447	S:S:R738	S:S:Y548	7.2	No	No	0	4	8
448	S:S:C557	S:S:Q549	6.1	No	Yes	34	9	7
449	S:S:Q549	S:S:T559	4.25	Yes	No	0	7	3
450	S:S:V552	S:S:Y550	8.83	No	Yes	0	6	7
451	S:S:C560	S:S:Y550	6.72	Yes	Yes	35	9	7
452	S:S:C573	S:S:Y550	10.75	No	Yes	35	9	7
453	S:S:K558	S:S:V552	4.55	No	No	0	1	6
454	S:S:D553	S:S:T556	4.34	No	No	0	7	4
455	S:S:T556	S:S:Y555	6.24	No	No	0	4	3
456	S:S:C560	S:S:M564	4.86	Yes	No	0	9	5
457	S:S:C560	S:S:C573	7.28	Yes	No	35	9	9
458	S:S:D563	S:S:I576	11.2	No	Yes	25	6	8
459	S:S:D563	S:S:D728	10.65	No	No	25	6	6
460	S:S:D563	S:S:D731	9.31	No	Yes	25	6	6
461	S:S:R565	S:S:R574	7.46	No	No	0	7	4
462	S:S:I576	S:S:R565	7.52	Yes	No	0	8	7
463	S:S:P566	S:S:R738	7.21	No	No	0	8	4
464	S:S:R574	S:S:T567	7.76	No	Yes	0	4	7
465	S:S:N569	S:S:T571	8.77	No	No	0	4	6
466	S:S:D731	S:S:I576	11.2	Yes	Yes	25	6	8
467	S:S:I578	S:S:K580	4.36	No	No	0	5	6
468	S:S:I579	S:S:R741	5.01	No	Yes	0	5	5
469	S:S:I579	S:S:Y816	8.46	No	No	0	5	5
470	S:S:L581	S:S:S585	4.5	No	No	0	8	7
471	S:S:E582	S:S:W583	4.36	No	No	0	6	5
472	S:S:A645	S:S:E582	4.53	No	No	0	7	6
473	S:S:E582	S:S:E646	5.07	No	No	0	6	5
474	S:S:G584	S:S:W583	5.63	No	No	0	4	5
475	S:S:I817	S:S:W587	8.22	No	No	0	5	5
476	S:S:L590	S:S:P591	4.93	No	No	0	4	8
477	S:S:L590	X:X:?1	8.25	No	Yes	0	4	0
478	S:S:P591	S:S:V824	5.3	No	No	0	8	7
479	S:S:F593	S:S:L594	6.09	No	No	0	2	4
480	S:S:F593	S:S:V597	6.55	No	No	0	2	2
481	S:S:A595	S:S:F641	8.32	No	Yes	0	7	7
482	S:S:F641	S:S:V596	3.93	Yes	No	0	7	3
483	S:S:G598	S:S:Y637	8.69	No	Yes	0	7	8
484	S:S:F641	S:S:I599	3.77	Yes	Yes	0	7	6
485	S:S:F604	S:S:T608	6.49	No	No	0	4	6
486	S:S:L630	S:S:V605	5.96	No	No	37	9	6
487	S:S:V605	S:S:Y838	7.57	No	Yes	37	6	9
488	S:S:I607	S:S:R611	3.76	No	No	0	1	4
489	S:S:F609	S:S:K619	14.89	No	Yes	0	8	7
490	S:S:F609	S:S:Y838	7.22	No	Yes	0	8	9
491	S:S:F609	S:S:K841	4.96	No	No	0	8	9
492	S:S:V610	S:S:Y627	3.79	No	No	0	4	7
493	S:S:R611	S:S:Y612	12.35	No	No	0	4	5
494	S:S:D614	S:S:N613	5.39	No	No	0	5	6
495	S:S:K619	S:S:N613	13.99	Yes	No	0	7	6
496	S:S:P616	S:S:T615	5.25	No	No	0	8	9
497	S:S:I617	S:S:T615	4.56	No	No	0	7	9
498	S:S:K619	S:S:T615	4.5	Yes	No	0	7	9
499	S:S:K841	S:S:V618	9.11	No	No	0	9	9
500	S:S:K619	S:S:Y627	4.78	Yes	No	0	7	7
501	S:S:A620	S:S:R623	4.15	No	No	0	9	8
502	S:S:G622	S:S:S621	3.71	No	No	0	9	9
503	S:S:N782	S:S:S621	5.96	No	No	38	9	9
504	S:S:E783	S:S:S621	5.75	Yes	No	38	9	9
505	S:S:G622	S:S:S626	3.71	No	No	0	9	8
506	S:S:L625	S:S:T672	4.42	No	Yes	39	8	7
507	S:S:K673	S:S:L625	7.05	No	No	0	9	8
508	S:S:L625	S:S:Q699	6.65	No	Yes	39	8	8
509	S:S:S626	S:S:Y838	7.63	No	Yes	0	8	9
510	S:S:L629	S:S:Y838	5.86	No	Yes	0	8	9
511	S:S:L630	S:S:Y838	11.72	No	Yes	37	9	9
512	S:S:A830	S:S:I633	4.87	No	Yes	0	8	9
513	S:S:S827	S:S:Y637	5.09	No	Yes	0	9	8
514	S:S:A830	S:S:Y637	4	No	Yes	0	8	8
515	S:S:S831	S:S:Y637	5.09	No	Yes	0	5	8
516	S:S:T640	S:S:T823	4.71	No	No	0	7	7
517	S:S:S827	S:S:T640	7.99	No	No	0	9	7
518	S:S:L642	S:S:R655	8.5	No	Yes	0	5	8
519	S:S:M643	S:S:R655	4.96	No	Yes	0	7	8
520	S:S:M643	S:S:T823	4.52	No	No	0	7	7
521	S:S:L744	S:S:P647	13.14	No	No	0	7	9
522	S:S:D648	S:S:T651	7.23	No	No	0	5	6
523	S:S:R655	S:S:T651	7.76	Yes	No	0	8	6
524	S:S:C652	S:S:R655	4.18	No	Yes	0	9	8
525	S:S:C652	S:S:C746	7.28	No	No	0	9	9
526	S:S:R656	S:S:W717	17.99	No	Yes	0	8	8
527	S:S:F718	S:S:R656	4.28	Yes	No	0	7	8
528	S:S:F658	S:S:I657	5.02	No	No	0	6	5
529	S:S:L659	S:S:M663	4.24	No	No	0	8	8
530	S:S:M663	S:S:V826	6.09	No	Yes	0	8	8
531	S:S:I665	S:S:S664	4.64	No	No	0	7	7
532	S:S:Q710	S:S:S664	12.99	No	No	0	9	7
533	S:S:I665	S:S:I707	8.83	No	No	0	7	7
534	S:S:T794	S:S:Y667	7.49	No	No	0	8	6
535	S:S:I787	S:S:L670	11.42	No	No	0	9	7
536	S:S:L671	S:S:T766	5.9	No	No	0	8	4
537	S:S:Q699	S:S:T672	8.5	Yes	Yes	39	8	7
538	S:S:I702	S:S:T672	4.56	No	Yes	0	6	7
539	S:S:T672	S:S:T703	6.28	Yes	Yes	0	7	7
540	S:S:I787	S:S:K673	4.36	No	No	0	9	9
541	S:S:I677	S:S:T674	4.56	No	No	0	9	9
542	S:S:T674	S:S:Y770	6.24	No	No	0	9	7
543	S:S:N675	S:S:R679	9.64	No	No	0	6	7
544	S:S:N675	S:S:Y770	15.12	No	No	0	6	7
545	S:S:I680	S:S:R676	7.52	No	No	0	9	8
546	S:S:Q699	S:S:R676	11.68	Yes	No	0	8	8
547	S:S:I677	S:S:T774	6.08	No	No	0	9	8
548	S:S:E682	S:S:Y678	15.71	No	No	0	6	6
549	S:S:K773	S:S:Y678	23.89	No	No	0	7	6
550	S:S:R679	S:S:R692	5.33	No	No	0	7	5
551	S:S:I680	S:S:I694	8.83	No	No	0	9	7
552	S:S:F781	S:S:I680	3.77	No	No	0	9	9
553	S:S:F681	S:S:V777	7.87	No	Yes	0	9	8
554	S:S:F693	S:S:R692	31	No	No	0	5	5
555	S:S:F704	S:S:L700	12.18	No	No	0	4	5
556	S:S:Q710	S:S:Y759	6.76	No	Yes	0	9	8
557	S:S:F718	S:S:I714	3.77	Yes	No	0	7	6
558	S:S:S752	S:S:W717	4.94	No	Yes	0	6	8
559	S:S:D721	S:S:S723	5.89	Yes	No	40	6	8
560	S:S:D721	S:S:D747	17.3	Yes	No	40	6	5
561	S:S:D747	S:S:S723	8.83	No	No	40	5	8
562	S:S:L744	S:S:S725	4.5	No	No	0	7	5
563	S:S:D728	S:S:V727	10.22	No	No	0	6	4
564	S:S:D728	S:S:D731	10.65	No	Yes	25	6	6
565	S:S:F729	S:S:Q730	26.94	No	No	0	4	3
566	S:S:Q730	S:S:R733	14.02	No	No	0	3	6
567	S:S:L735	S:S:T734	5.9	No	No	0	6	4
568	R:R:D736	S:S:L735	4.07	No	No	0	3	6
569	S:S:D736	S:S:P737	4.83	No	No	0	3	5
570	S:S:F739	S:S:P737	7.22	No	No	0	3	5
571	S:S:A740	S:S:R741	4.15	No	Yes	0	4	5
572	S:S:L815	S:S:V743	7.45	No	No	0	6	6
573	S:S:V743	S:S:Y816	8.83	No	No	0	6	5
574	S:S:K745	S:S:L815	8.46	No	No	0	7	6
575	S:S:I748	S:S:S752	7.74	No	No	0	5	6
576	S:S:D750	S:S:I754	8.4	No	No	41	3	5
577	S:S:D750	S:S:F805	5.97	No	No	41	3	8
578	S:S:L753	S:S:L757	5.54	No	No	0	7	8
579	S:S:L753	S:S:L822	6.92	No	No	0	7	8
580	S:S:F805	S:S:I754	3.77	No	No	41	8	5
581	S:S:L757	S:S:M761	4.24	No	Yes	0	8	6
582	S:S:F801	S:S:L757	7.31	Yes	No	0	9	8
583	S:S:L763	S:S:Y759	15.24	No	Yes	0	9	8
584	S:S:M761	S:S:S760	4.6	Yes	No	0	6	8
585	S:S:M761	S:S:W798	15.12	Yes	Yes	0	6	9
586	S:S:M764	S:S:T794	7.53	No	No	0	8	8
587	S:S:M764	S:S:W798	4.65	No	Yes	0	8	9
588	S:S:C767	S:S:M791	6.48	No	Yes	0	8	9
589	S:S:M791	S:S:T768	6.02	Yes	No	0	9	8
590	S:S:K773	S:S:Y770	4.78	No	No	0	7	7
591	S:S:F781	S:S:V777	6.55	No	Yes	0	9	8
592	S:S:E783	S:S:N782	3.94	Yes	No	38	9	9
593	S:S:E783	S:S:L837	7.95	Yes	No	0	9	8
594	S:S:E783	S:S:K841	9.45	Yes	No	0	9	9
595	S:S:K785	S:S:P786	5.02	No	No	0	9	5
596	S:S:F789	S:S:K785	12.41	No	No	0	9	9
597	R:R:K785	S:S:K785	4.31	No	No	0	9	9
598	S:S:F789	S:S:M836	6.22	No	No	4	9	7
599	R:R:F789	S:S:F789	13.93	No	No	4	9	9
600	S:S:T793	S:S:V832	11.11	Yes	No	4	8	7
601	R:R:F789	S:S:T793	3.89	No	Yes	4	9	8
602	R:R:Y792	S:S:T793	3.75	Yes	Yes	4	9	8
603	R:R:T793	S:S:I796	4.56	No	No	0	8	8
604	R:R:Y792	S:S:V797	3.79	Yes	No	4	9	8
605	R:R:I796	S:S:V797	4.61	No	No	4	8	8
606	S:S:F801	S:S:W798	10.02	Yes	Yes	4	9	9
607	S:S:S825	S:S:W798	4.94	No	Yes	4	8	9
608	S:S:F801	S:S:I802	3.77	Yes	No	0	9	7
609	S:S:F801	S:S:S825	7.93	Yes	No	4	9	8
610	S:S:F806	S:S:I802	3.77	No	No	0	6	7
611	S:S:F806	S:S:P803	7.22	No	No	0	6	9
612	S:S:I804	S:S:T821	9.12	No	No	4	7	8
613	S:S:I804	X:X:?1	5.32	No	Yes	4	7	0
614	S:S:I817	S:S:T808	6.08	No	No	0	5	8
615	S:S:Q810	S:S:S809	5.78	No	No	0	8	6
616	S:S:D813	S:S:Y816	6.9	No	No	0	4	5
617	S:S:K814	S:S:Q818	5.42	No	No	0	6	6
618	S:S:T821	X:X:?1	4.4	No	Yes	4	8	0
619	S:S:V824	X:X:?1	18.88	No	Yes	0	7	0
620	S:S:S825	X:X:?1	6.72	No	Yes	4	8	0
621	R:R:Y792	S:S:L828	5.86	Yes	No	4	9	6
622	R:R:I796	S:S:L828	4.28	No	No	4	8	6
623	S:S:L828	X:X:?1	4.13	No	Yes	4	6	0
624	R:R:Y792	S:S:V832	5.05	Yes	No	4	9	7
625	S:S:L834	S:S:Y838	4.69	No	Yes	0	8	9
626	R:R:F789	S:S:M836	6.22	No	No	4	9	7
627	S:S:F847	S:S:Y843	14.44	No	No	0	5	8
628	R:R:R775	S:S:Y843	11.32	No	No	0	9	8
629	R:R:N41	R:R:R44	7.23	No	No	0	5	4
630	R:R:R44	R:R:S42	11.86	No	No	0	4	3
631	R:R:L106	R:R:S42	4.5	No	No	0	5	3
632	R:R:I105	R:R:I43	5.89	No	No	1	8	4
633	R:R:I43	R:R:N359	8.5	No	Yes	1	4	7
634	R:R:I43	R:R:W361	4.7	No	Yes	1	4	5
635	R:R:R104	R:R:R44	6.4	Yes	No	0	5	4
636	R:R:A103	R:R:I45	4.87	No	No	0	7	4
637	R:R:I45	R:R:R358	3.76	No	No	0	4	4
638	R:R:G47	R:R:T100	3.64	No	No	0	9	7
639	R:R:D48	R:R:I99	5.6	No	Yes	0	8	5
640	R:R:D48	R:R:T100	7.23	No	No	0	8	7
641	R:R:D48	R:R:L434	4.07	No	No	0	8	3
642	R:R:I49	R:R:L101	5.71	Yes	Yes	0	6	9
643	R:R:I49	R:R:V151	7.68	Yes	No	0	6	4
644	R:R:I49	R:R:L420	5.71	Yes	No	0	6	8
645	R:R:R104	R:R:T50	3.88	Yes	No	0	5	4
646	R:R:E148	R:R:T50	7.06	No	No	0	4	4
647	R:R:T50	R:R:V150	4.76	No	No	0	4	5
648	R:R:F122	R:R:G52	4.52	Yes	No	42	5	8
649	R:R:G52	R:R:V153	5.52	No	No	42	8	6
650	R:R:L54	R:R:T108	5.9	No	No	0	6	6
651	R:R:F55	R:R:L79	8.53	Yes	No	0	9	5
652	R:R:F55	R:R:M82	4.98	Yes	No	1	9	8
653	R:R:F55	R:R:I105	5.02	Yes	No	1	9	8
654	R:R:F55	R:R:Y179	10.32	Yes	Yes	1	9	8
655	R:R:K74	R:R:P56	8.36	Yes	No	1	5	5
656	R:R:P56	R:R:S157	7.13	No	Yes	1	5	5
657	R:R:H58	R:R:V57	4.15	Yes	Yes	1	8	6
658	R:R:L79	R:R:V57	5.96	No	Yes	0	5	6
659	R:R:D107	R:R:V57	8.76	Yes	Yes	1	9	6
660	R:R:V57	R:R:W361	9.81	Yes	Yes	1	6	5
661	R:R:C67	R:R:H58	4.42	No	Yes	1	9	8
662	R:R:H58	R:R:L70	10.29	Yes	No	0	8	5
663	R:R:D107	R:R:H58	10.08	Yes	Yes	1	9	8
664	R:R:C109	R:R:H58	5.9	Yes	Yes	1	7	8
665	R:R:G59	R:R:S110	3.71	No	No	0	3	4
666	R:R:N286	R:R:R60	7.23	No	No	0	5	2
667	R:R:E63	R:R:S62	5.75	No	No	0	1	1
668	R:R:C109	R:R:C67	7.28	Yes	No	1	7	9
669	R:R:D368	R:R:E69	3.9	No	No	0	3	4
670	R:R:F365	R:R:K72	9.93	Yes	No	1	6	4
671	R:R:D368	R:R:K72	15.21	No	No	0	3	4
672	R:R:K72	R:R:N369	9.79	No	Yes	1	4	3
673	R:R:E73	R:R:H77	11.08	Yes	Yes	1	2	6
674	R:R:E403	R:R:E73	5.07	Yes	Yes	1	5	2
675	R:R:K74	R:R:R78	9.9	Yes	Yes	1	5	4
676	R:R:K74	R:R:S157	4.59	Yes	Yes	1	5	5
677	R:R:E287	R:R:K74	6.75	No	Yes	0	3	5
678	L:L:?1	R:R:K74	4.79	Yes	Yes	1	0	5
679	R:R:F365	R:R:I76	16.33	Yes	No	0	6	5
680	R:R:F348	R:R:H77	7.92	Yes	Yes	1	7	6
681	R:R:H77	R:R:Y400	4.36	Yes	No	1	6	5
682	R:R:E403	R:R:H77	8.62	Yes	Yes	1	5	6
683	R:R:R78	R:R:S157	9.22	Yes	Yes	1	4	5
684	R:R:R78	R:R:Y179	9.26	Yes	Yes	1	4	8
685	R:R:E403	R:R:R78	6.98	Yes	Yes	1	5	4
686	R:R:K405	R:R:R78	9.9	Yes	Yes	1	4	4
687	L:L:?1	R:R:R78	5.16	Yes	Yes	1	0	4
688	R:R:L79	R:R:N359	6.87	No	Yes	0	5	7
689	R:R:E80	R:R:L83	3.98	Yes	No	0	8	5
690	R:R:E80	R:R:Y347	7.86	Yes	No	1	8	7
691	R:R:E80	R:R:F348	7	Yes	Yes	1	8	7
692	R:R:E80	R:R:R351	4.65	Yes	Yes	1	8	5
693	R:R:E80	R:R:N356	5.26	Yes	No	1	8	4
694	R:R:E80	R:R:F362	8.16	Yes	Yes	1	8	5
695	R:R:A81	R:R:F344	4.16	No	No	26	7	8
696	R:R:A81	R:R:V406	5.09	No	No	26	7	6
697	R:R:I105	R:R:M82	4.37	No	No	1	8	8
698	R:R:L83	R:R:R358	15.79	No	No	0	5	4
699	R:R:F84	R:R:R88	8.55	No	No	0	7	8
700	R:R:F84	R:R:Y347	9.28	No	No	0	7	7
701	R:R:A85	R:R:V413	5.09	No	No	0	8	9
702	R:R:L101	R:R:L86	4.15	Yes	No	0	9	7
703	R:R:D87	R:R:R358	9.53	No	No	0	7	4
704	R:R:R88	R:R:Y414	5.14	No	No	0	8	8
705	R:R:I458	R:R:R88	7.52	No	No	0	3	8
706	R:R:I89	R:R:L95	5.71	No	Yes	0	9	7
707	R:R:I89	R:R:L101	4.28	No	Yes	0	9	9
708	R:R:N90	R:R:T100	8.77	No	No	0	9	7
709	R:R:L101	R:R:N90	6.87	Yes	No	0	9	9
710	R:R:D92	R:R:P93	6.44	No	No	0	7	3
711	R:R:D92	R:R:D94	3.99	No	No	0	7	3
712	R:R:D92	R:R:L95	4.07	No	Yes	0	7	7
713	R:R:H418	R:R:L95	6.43	No	Yes	0	6	7
714	R:R:H421	R:R:L95	3.86	No	Yes	0	7	7
715	R:R:I99	R:R:L96	9.99	Yes	No	0	5	9
716	R:R:F122	R:R:R104	5.34	Yes	Yes	0	5	5
717	R:R:L106	R:R:Q118	13.31	No	No	0	5	5
718	R:R:F122	R:R:L106	7.31	Yes	No	0	5	5
719	R:R:C109	R:R:D107	4.67	Yes	Yes	1	7	9
720	R:R:D107	R:R:W361	7.82	Yes	Yes	1	9	5
721	R:R:C109	R:R:H114	8.85	Yes	No	0	7	3
722	R:R:R111	R:R:T113	5.17	No	No	0	5	3
723	R:R:D112	R:R:S160	8.83	Yes	No	0	4	5
724	R:R:D112	R:R:M164	12.48	Yes	Yes	11	4	5
725	R:R:H114	R:R:Q118	11.13	No	No	0	3	5
726	R:R:A115	R:R:V161	5.09	No	Yes	0	7	4
727	R:R:L116	R:R:M164	7.07	Yes	Yes	11	5	5
728	R:R:S119	R:R:V165	4.85	No	No	0	6	5
729	R:R:L120	R:R:Q124	9.32	No	No	0	5	7
730	R:R:F122	R:R:V153	7.87	Yes	No	42	5	6
731	R:R:F172	R:R:V123	18.35	No	No	0	6	5
732	R:R:G152	R:R:V151	3.68	No	No	0	8	4
733	R:R:L169	R:R:V153	5.96	No	No	0	6	6
734	R:R:G155	R:R:Q176	4.93	No	Yes	0	8	8
735	R:R:G155	R:R:S178	3.71	No	No	0	8	9
736	R:R:S157	R:R:Y179	7.63	Yes	Yes	1	5	8
737	R:R:S159	R:R:S181	6.52	Yes	No	0	9	8
738	R:R:S159	R:R:Y230	6.36	Yes	Yes	1	9	7
739	L:L:?1	R:R:S159	8.92	Yes	Yes	1	0	9
740	R:R:S162	R:R:S181	6.52	No	No	0	7	8
741	R:R:L186	R:R:S162	4.5	Yes	No	43	8	7
742	R:R:F195	R:R:S162	5.28	Yes	No	43	8	7
743	R:R:I163	R:R:L186	4.28	No	Yes	0	6	8
744	R:R:I163	R:R:Y192	9.67	No	No	0	6	5
745	R:R:I163	R:R:S229	4.64	No	No	0	6	6
746	R:R:Q176	R:R:V165	5.73	Yes	No	0	8	5
747	R:R:A166	R:R:Y192	4	No	No	0	7	5
748	R:R:A166	R:R:F195	4.16	No	Yes	0	7	8
749	R:R:I168	R:R:N167	5.66	No	No	11	5	5
750	R:R:L169	R:R:Q176	7.99	No	Yes	0	6	8
751	R:R:L171	R:R:R170	4.86	Yes	No	0	5	5
752	R:R:D193	R:R:R170	19.06	No	No	0	6	5
753	R:R:F194	R:R:K173	6.2	Yes	No	0	7	4
754	R:R:F194	R:R:P175	4.33	Yes	Yes	0	7	8
755	R:R:L446	R:R:P175	6.57	No	Yes	0	6	8
756	R:R:F195	R:R:Q176	11.71	Yes	Yes	0	8	8
757	R:R:I177	R:R:M416	4.37	No	No	0	7	6
758	R:R:I177	R:R:I450	7.36	No	No	0	7	7
759	R:R:S178	R:R:S181	6.52	No	No	0	9	8
760	R:R:F195	R:R:S178	5.28	Yes	No	0	8	9
761	R:R:V409	R:R:Y179	8.83	No	Yes	0	7	8
762	R:R:A180	R:R:K405	6.42	No	Yes	0	6	4
763	R:R:D202	R:R:T182	8.67	Yes	Yes	1	8	8
764	R:R:T182	R:R:Y230	3.75	Yes	Yes	1	8	7
765	R:R:D312	R:R:T182	5.78	Yes	Yes	1	8	8
766	L:L:?1	R:R:T182	5.01	Yes	Yes	1	0	8
767	R:R:P184	R:R:S201	5.34	No	No	0	5	8
768	R:R:D202	R:R:P184	6.44	Yes	No	0	8	5
769	R:R:P184	R:R:S233	5.34	No	No	0	5	4
770	R:R:F195	R:R:L186	21.92	Yes	Yes	43	8	8
771	R:R:L186	R:R:R197	6.07	Yes	No	0	8	9
772	R:R:N468	R:R:S187	4.47	Yes	No	44	7	8
773	R:R:D470	R:R:S187	8.83	Yes	No	44	7	8
774	R:R:D188	R:R:S190	8.83	No	No	0	6	2
775	R:R:D188	R:R:R191	8.34	No	No	0	6	5
776	R:R:N189	R:R:N468	4.09	No	Yes	0	7	7
777	R:R:R191	R:R:Y192	20.58	No	No	0	5	5
778	R:R:D193	R:R:F194	9.55	No	Yes	0	6	7
779	R:R:F194	R:R:L447	12.18	Yes	No	0	7	6
780	R:R:R451	R:R:S196	7.91	No	No	0	6	6
781	R:R:R197	R:R:S201	9.22	No	No	0	9	8
782	R:R:D470	R:R:R197	14.29	Yes	No	0	7	9
783	R:R:F408	R:R:V199	9.18	Yes	No	0	7	7
784	R:R:P200	R:R:Y204	5.56	Yes	No	0	7	4
785	R:R:P200	R:R:P336	7.79	Yes	Yes	1	7	5
786	R:R:A471	R:R:P200	5.61	No	Yes	0	4	7
787	R:R:G473	R:R:P200	4.06	No	Yes	0	5	7
788	R:R:P200	R:R:Y475	12.52	Yes	Yes	1	7	8
789	R:R:D202	R:R:Q205	10.44	Yes	Yes	1	8	9
790	R:R:D202	R:R:Y230	6.9	Yes	Yes	1	8	7
791	R:R:D202	R:R:G234	5.03	Yes	No	0	8	7
792	R:R:T203	R:R:Y204	8.74	No	No	0	3	4
793	R:R:D470	R:R:Y204	4.6	Yes	No	0	7	4
794	R:R:F284	R:R:Q205	7.03	Yes	Yes	1	8	9
795	R:R:D312	R:R:Q205	7.83	Yes	Yes	1	8	9
796	R:R:I334	R:R:Q205	4.12	No	Yes	1	7	9
797	R:R:Q205	R:R:Y475	9.02	Yes	Yes	1	9	8
798	R:R:D211	R:R:Q207	7.83	No	Yes	1	5	4
799	R:R:K241	R:R:Q207	12.2	No	Yes	1	5	4
800	R:R:E244	R:R:Q207	5.1	No	Yes	1	4	4
801	R:R:Q207	R:R:W495	5.48	Yes	Yes	1	4	5
802	R:R:A208	R:R:W495	10.37	No	Yes	0	7	5
803	R:R:F284	R:R:M209	3.73	Yes	No	0	8	7
804	R:R:D211	R:R:W495	7.82	No	Yes	1	5	5
805	R:R:I212	R:R:M309	4.37	No	No	0	8	6
806	R:R:V213	R:R:W218	3.68	No	Yes	0	6	9
807	R:R:V213	R:R:V248	4.81	No	No	0	6	7
808	R:R:N219	R:R:R214	4.82	No	No	0	6	4
809	R:R:L216	R:R:W218	12.53	No	Yes	0	8	9
810	R:R:K217	R:R:R517	7.43	No	No	0	4	1
811	R:R:A280	R:R:W218	5.19	No	Yes	0	8	9
812	R:R:F307	R:R:W218	6.01	Yes	Yes	14	7	9
813	R:R:W218	R:R:W508	5.62	Yes	Yes	14	9	8
814	R:R:P516	R:R:W218	6.76	Yes	Yes	14	8	9
815	R:R:S518	R:R:W218	11.12	No	Yes	0	9	9
816	R:R:I519	R:R:N219	4.25	No	No	0	5	6
817	R:R:A251	R:R:Y220	8.01	No	Yes	0	8	9
818	R:R:T275	R:R:Y220	3.75	No	Yes	0	3	9
819	R:R:C520	R:R:Y220	12.1	No	Yes	0	9	9
820	R:R:L272	R:R:S222	4.5	Yes	No	8	8	8
821	R:R:S222	R:R:V281	4.85	No	Yes	8	8	6
822	R:R:T223	R:R:V235	4.76	No	No	0	5	5
823	R:R:I250	R:R:T223	4.56	No	No	0	6	5
824	R:R:S253	R:R:T223	7.99	No	No	0	4	5
825	R:R:V224	R:R:V254	4.81	No	No	0	5	5
826	R:R:I283	R:R:V224	10.75	No	No	0	5	5
827	R:R:A225	R:R:V235	5.09	No	No	0	5	5
828	R:R:A225	R:R:K255	4.82	No	No	0	5	4
829	R:R:E227	R:R:R258	17.45	No	No	0	7	4
830	R:R:G228	R:R:R258	4.5	No	No	0	6	4
831	R:R:G231	R:R:Y230	4.35	No	Yes	0	8	7
832	R:R:F284	R:R:Y230	4.13	Yes	Yes	1	8	7
833	R:R:S311	R:R:Y230	5.09	No	Yes	1	8	7
834	R:R:S313	R:R:Y230	3.82	No	Yes	1	6	7
835	L:L:?1	R:R:Y230	31.85	Yes	Yes	1	0	7
836	R:R:E232	R:R:K255	12.15	No	No	0	5	4
837	R:R:F284	R:R:G234	6.02	Yes	No	0	8	7
838	R:R:F284	R:R:V235	3.93	Yes	No	0	8	5
839	R:R:F238	R:R:I282	5.02	No	No	0	7	7
840	R:R:I239	R:R:R243	3.76	No	No	0	4	3
841	R:R:I239	R:R:I250	5.89	No	No	0	4	6
842	R:R:Q240	R:R:R243	11.68	No	No	0	4	3
843	R:R:E244	R:R:K241	4.05	No	No	1	4	5
844	R:R:C249	R:R:C538	7.28	No	No	0	9	9
845	R:R:L272	R:R:Q252	3.99	Yes	No	0	8	6
846	R:R:Q252	R:R:T275	5.67	No	No	0	6	3
847	R:R:I268	R:R:V254	4.61	No	No	0	5	5
848	R:R:R271	R:R:V254	6.54	No	No	0	3	5
849	R:R:F265	R:R:I256	3.77	Yes	No	17	4	5
850	R:R:D289	R:R:I256	11.2	Yes	No	17	4	5
851	R:R:E264	R:R:P257	9.43	Yes	No	0	3	4
852	R:R:E264	R:R:P260	4.72	Yes	No	0	3	2
853	R:R:F265	R:R:P260	4.33	Yes	No	0	4	2
854	R:R:K261	R:R:K267	4.31	No	No	45	3	2
855	R:R:D266	R:R:G263	5.03	No	No	0	3	1
856	R:R:E264	R:R:I268	8.2	Yes	No	0	3	5
857	R:R:D289	R:R:F265	4.78	Yes	Yes	17	4	4
858	R:R:F265	R:R:R292	17.1	Yes	Yes	17	4	1
859	R:R:F265	R:R:V293	3.93	Yes	No	0	4	5
860	R:R:D266	R:R:R299	5.96	No	No	0	3	3
861	R:R:K267	R:R:R270	8.66	No	No	0	2	1
862	R:R:L272	R:R:V281	4.47	Yes	Yes	8	8	6
863	R:R:F306	R:R:L272	9.74	Yes	Yes	8	7	8
864	R:R:L273	R:R:Q302	13.31	No	No	0	5	4
865	R:R:H305	R:R:S276	5.58	Yes	No	0	3	7
866	R:R:H305	R:R:R279	4.51	Yes	No	0	3	6
867	R:R:F307	R:R:R279	4.28	Yes	No	0	7	6
868	R:R:F306	R:R:V281	5.24	Yes	Yes	8	7	6
869	R:R:V281	R:R:W308	4.9	Yes	Yes	8	6	7
870	R:R:I282	R:R:M309	10.2	No	No	0	7	6
871	R:R:I283	R:R:I290	5.89	No	No	0	5	4
872	R:R:F284	R:R:S311	13.21	Yes	No	1	8	8
873	R:R:A285	R:R:D289	4.63	No	Yes	0	4	4
874	R:R:D288	R:R:N286	13.46	No	No	17	1	5
875	R:R:D289	R:R:N286	10.77	Yes	No	17	4	5
876	R:R:E287	R:R:K317	4.05	No	No	0	3	6
877	R:R:E287	R:R:P320	7.86	No	No	0	3	5
878	R:R:D288	R:R:D289	3.99	No	Yes	17	1	4
879	R:R:D288	R:R:R292	7.15	No	Yes	17	1	1
880	R:R:D289	R:R:R292	4.76	Yes	Yes	17	4	1
881	R:R:I290	R:R:W314	5.87	No	Yes	0	4	7
882	R:R:R291	R:R:R292	4.26	No	Yes	0	1	1
883	R:R:E295	R:R:R291	4.65	No	No	0	2	1
884	R:R:L324	R:R:R291	3.64	Yes	No	0	4	1
885	R:R:L294	R:R:W308	7.97	Yes	Yes	8	5	7
886	R:R:L294	R:R:L324	8.3	Yes	Yes	8	5	4
887	R:R:L294	R:R:V327	8.94	Yes	Yes	8	5	3
888	R:R:E295	R:R:R299	15.12	No	No	0	2	3
889	R:R:A296	R:R:R299	5.53	No	No	0	5	3
890	R:R:L324	R:R:R298	4.86	Yes	No	8	4	3
891	R:R:E326	R:R:R298	9.3	No	No	0	3	3
892	R:R:R298	R:R:V327	14.38	No	Yes	8	3	3
893	R:R:H305	R:R:Q302	14.84	Yes	No	8	3	4
894	R:R:F306	R:R:Q302	4.68	Yes	No	8	7	4
895	R:R:E329	R:R:G304	4.91	No	No	0	5	3
896	R:R:F306	R:R:H305	9.05	Yes	Yes	8	7	3
897	R:R:F306	R:R:W308	14.03	Yes	Yes	8	7	7
898	R:R:F307	R:R:W508	8.02	Yes	Yes	14	7	8
899	R:R:F307	R:R:P516	7.22	Yes	Yes	14	7	8
900	R:R:V327	R:R:W308	3.68	Yes	Yes	8	3	7
901	R:R:M309	R:R:V332	6.09	No	No	0	6	5
902	R:R:G310	R:R:W314	5.63	No	Yes	0	7	7
903	R:R:D312	R:R:P336	9.66	Yes	Yes	1	8	5
904	R:R:D312	R:R:Y475	4.6	Yes	Yes	1	8	8
905	R:R:S313	R:R:W314	6.18	No	Yes	1	6	7
906	L:L:?1	R:R:S313	3.82	Yes	No	1	0	6
907	R:R:P320	R:R:W314	5.4	No	Yes	0	5	7
908	R:R:V321	R:R:W314	3.68	No	Yes	1	4	7
909	R:R:T333	R:R:W314	3.64	No	Yes	0	7	7
910	R:R:W314	R:R:Y489	5.79	Yes	Yes	1	7	5
911	R:R:G315	R:R:L335	5.13	No	No	0	5	5
912	R:R:S316	R:R:Y489	6.36	No	Yes	0	5	5
913	R:R:E403	R:R:K317	10.8	Yes	No	0	5	6
914	R:R:V321	R:R:Y480	8.83	No	No	1	4	6
915	R:R:V321	R:R:Y489	5.05	No	Yes	1	4	5
916	R:R:E325	R:R:H323	8.62	Yes	No	0	4	1
917	R:R:L324	R:R:V327	4.47	Yes	Yes	8	4	3
918	R:R:E325	R:R:E326	3.81	Yes	No	0	4	3
919	R:R:E325	R:R:L482	5.3	Yes	No	0	4	3
920	R:R:G330	R:R:Q479	4.93	No	Yes	0	8	8
921	R:R:I334	R:R:Y475	8.46	No	Yes	1	7	8
922	R:R:L335	R:R:P336	4.93	No	Yes	0	5	5
923	R:R:L335	R:R:Y478	7.03	No	No	0	5	4
924	R:R:F408	R:R:P336	7.22	Yes	Yes	0	7	5
925	R:R:P336	R:R:Y475	9.74	Yes	Yes	1	5	8
926	R:R:K337	R:R:R474	12.38	No	No	0	5	4
927	R:R:D476	R:R:K337	15.21	No	No	0	8	5
928	R:R:G404	R:R:R338	6	No	No	0	5	5
929	R:R:R342	R:R:S340	7.91	No	No	0	4	3
930	R:R:G343	R:R:R346	4.5	No	No	0	5	3
931	R:R:F344	R:R:Q402	9.37	No	Yes	26	8	6
932	R:R:F344	R:R:V406	14.42	No	No	26	8	6
933	R:R:D345	R:R:Y400	8.05	No	No	0	4	5
934	R:R:D345	R:R:Q402	6.53	No	Yes	0	4	6
935	R:R:R351	R:R:Y347	20.58	Yes	No	1	5	7
936	R:R:F348	R:R:F365	4.29	Yes	Yes	1	7	6
937	R:R:F348	R:R:I394	11.3	Yes	No	1	7	5
938	R:R:F348	R:R:Y400	6.19	Yes	No	1	7	5
939	R:R:N355	R:R:R351	4.82	No	Yes	0	4	5
940	R:R:N356	R:R:R351	14.46	No	Yes	1	4	5
941	R:R:N355	R:R:T352	8.77	No	No	0	4	4
942	R:R:R393	R:R:T352	3.88	No	No	0	4	4
943	R:R:L353	R:R:W366	17.08	Yes	No	0	6	6
944	R:R:F362	R:R:N356	12.08	Yes	No	1	5	4
945	R:R:N359	R:R:W361	6.78	Yes	Yes	1	7	5
946	R:R:F362	R:R:N359	4.83	Yes	Yes	1	5	7
947	R:R:I360	R:R:W361	9.4	No	Yes	0	3	5
948	R:R:F362	R:R:F365	8.57	Yes	Yes	1	5	6
949	R:R:F365	R:R:N369	15.71	Yes	Yes	1	6	3
950	R:R:F365	R:R:I394	3.77	Yes	No	1	6	5
951	R:R:F370	R:R:W366	18.04	Yes	No	0	8	6
952	R:R:E367	R:R:K373	17.55	No	No	0	6	4
953	R:R:F370	R:R:N369	7.25	Yes	Yes	1	8	3
954	R:R:D397	R:R:N369	6.73	No	Yes	1	3	3
955	R:R:E392	R:R:F370	16.32	No	Yes	0	7	8
956	R:R:F370	R:R:I394	3.77	Yes	No	1	8	5
957	R:R:D397	R:R:F370	8.36	No	Yes	1	3	8
958	R:R:C372	R:R:C388	5.46	No	No	0	8	8
959	R:R:K387	R:R:V385	7.59	No	No	0	1	1
960	R:R:R391	R:R:R393	9.6	No	No	0	3	4
961	R:R:E392	R:R:Q396	6.37	No	No	0	7	1
962	R:R:Q402	R:R:V406	4.3	Yes	No	26	6	6
963	R:R:F408	R:R:K405	6.2	Yes	Yes	0	7	4
964	L:L:?1	R:R:K405	8.38	Yes	Yes	1	0	4
965	R:R:D411	R:R:Q407	11.75	No	Yes	0	8	7
966	R:R:A459	R:R:Q407	6.06	No	Yes	46	4	7
967	R:R:N461	R:R:Q407	3.96	Yes	Yes	46	5	7
968	R:R:D411	R:R:V463	5.84	No	No	0	8	6
969	R:R:F455	R:R:H418	13.58	Yes	No	0	9	6
970	R:R:L420	R:R:L446	4.15	No	No	0	8	6
971	R:R:H421	R:R:R425	6.77	No	No	0	7	3
972	R:R:L427	R:R:M423	4.24	No	No	0	3	6
973	R:R:M423	R:R:M438	4.33	No	No	0	6	4
974	R:R:M423	R:R:Y449	9.58	No	Yes	0	6	4
975	R:R:C428	R:R:H424	7.37	Yes	Yes	47	7	5
976	R:R:C435	R:R:H424	4.42	No	Yes	47	6	5
977	R:R:H424	R:R:M438	3.94	Yes	No	0	5	4
978	R:R:D426	R:R:Y449	10.34	No	Yes	0	4	4
979	R:R:L427	R:R:R437	4.86	No	No	0	3	3
980	R:R:L427	R:R:Q445	3.99	No	No	0	3	6
981	R:R:C428	R:R:C435	7.28	Yes	No	47	7	6
982	R:R:C428	R:R:R437	4.18	Yes	No	0	7	3
983	R:R:D442	R:R:Q445	6.53	No	No	0	4	6
984	R:R:Q445	R:R:Y449	6.76	No	Yes	0	6	4
985	R:R:L447	R:R:R451	4.86	No	No	0	6	6
986	R:R:G469	R:R:R451	4.5	No	No	0	7	6
987	R:R:F455	R:R:V453	5.24	Yes	No	0	9	7
988	R:R:F465	R:R:V453	5.24	No	No	0	8	7
989	R:R:N454	R:R:T464	5.85	No	No	0	5	3
990	R:R:F455	R:R:V463	6.55	Yes	No	0	9	6
991	R:R:A459	R:R:N461	4.69	No	Yes	46	4	5
992	R:R:N461	R:R:R474	6.03	Yes	No	0	5	4
993	R:R:N466	R:R:N468	4.09	No	Yes	0	7	7
994	R:R:D470	R:R:N468	14.81	Yes	Yes	44	7	7
995	R:R:W495	R:R:Y475	6.75	Yes	Yes	1	5	8
996	R:R:D476	R:R:Y478	9.2	No	No	0	8	4
997	R:R:I477	R:R:I492	4.42	No	No	0	7	7
998	R:R:I477	R:R:L501	4.28	No	No	0	7	7
999	R:R:V491	R:R:Y478	7.57	No	No	0	5	4
1000	R:R:Q479	R:R:Q481	10.24	Yes	No	0	8	7
1001	R:R:I492	R:R:Q479	8.23	No	Yes	14	7	8
1002	R:R:M506	R:R:Q479	6.8	No	Yes	14	7	8
1003	R:R:Q479	R:R:W508	14.24	Yes	Yes	14	8	8
1004	R:R:Y480	R:R:Y489	18.86	No	Yes	1	6	5
1005	R:R:K490	R:R:Q481	4.07	No	No	0	5	7
1006	R:R:H507	R:R:Q481	4.95	No	No	0	4	7
1007	R:R:H507	R:R:R483	7.9	No	No	0	4	3
1008	R:R:K490	R:R:R505	3.71	No	No	0	5	3
1009	R:R:I492	R:R:M506	7.29	No	No	14	7	7
1010	R:R:H500	R:R:S494	6.97	No	No	0	1	3
1011	R:R:H498	R:R:H500	13.14	No	No	0	4	1
1012	R:R:L499	R:R:L501	4.15	No	No	48	7	7
1013	R:R:E504	R:R:R502	15.12	No	No	0	3	5
1014	R:R:R502	R:R:R505	29.85	No	No	0	5	3
1015	R:R:P516	R:R:W508	16.21	Yes	Yes	14	8	8
1016	R:R:C520	R:R:C539	7.28	No	No	0	9	9
1017	R:R:C539	R:R:S521	5.16	No	No	0	9	8
1018	R:R:C524	R:R:C542	5.46	No	No	0	9	9
1019	R:R:E528	R:R:R529	17.45	No	No	0	5	6
1020	R:R:E528	R:R:R570	25.59	No	No	0	5	6
1021	R:R:P544	R:R:R529	10.09	No	No	0	4	6
1022	R:R:K530	R:R:T532	7.51	Yes	No	0	8	3
1023	R:R:E543	R:R:K530	21.6	No	Yes	0	4	8
1024	R:R:K530	R:R:T556	4.5	Yes	No	0	8	4
1025	R:R:K531	R:R:W540	32.49	No	No	0	6	8
1026	R:R:K534	R:R:M536	4.32	No	No	0	6	6
1027	R:R:C538	R:R:C539	3.64	No	No	0	9	9
1028	R:R:C545	R:R:Q549	4.58	No	No	0	9	7
1029	R:R:C545	R:R:C557	7.28	No	No	0	9	9
1030	R:R:Q549	R:R:T546	11.34	No	No	0	7	5
1031	R:R:L735	R:R:Y548	18.76	No	No	0	6	8
1032	R:R:D736	R:R:Y548	18.39	No	No	0	3	8
1033	R:R:V552	R:R:Y550	10.09	No	Yes	12	6	7
1034	R:R:K558	R:R:Y550	4.78	No	Yes	12	1	7
1035	R:R:C560	R:R:Y550	16.13	Yes	Yes	12	9	7
1036	R:R:G572	R:R:Y550	5.79	No	Yes	0	1	7
1037	R:R:C573	R:R:Y550	8.06	No	Yes	12	9	7
1038	R:R:K558	R:R:V552	7.59	No	No	12	1	6
1039	R:R:T556	R:R:Y555	4.99	No	No	0	4	3
1040	R:R:K558	R:R:T556	6.01	No	No	0	1	4
1041	R:R:C560	R:R:P561	3.77	Yes	No	12	9	4
1042	R:R:C560	R:R:M564	6.48	Yes	Yes	12	9	5
1043	R:R:C560	R:R:C573	7.28	Yes	No	12	9	9
1044	R:R:M564	R:R:P561	15.09	Yes	No	12	5	4
1045	R:R:D728	R:R:Y562	10.34	Yes	Yes	27	6	3
1046	R:R:Q730	R:R:Y562	10.15	Yes	Yes	27	3	3
1047	R:R:R733	R:R:Y562	7.2	No	Yes	0	6	3
1048	R:R:D563	R:R:D728	7.98	No	Yes	27	6	6
1049	R:R:D563	R:R:Q730	3.92	No	Yes	27	6	3
1050	R:R:C573	R:R:M564	11.35	No	Yes	12	9	5
1051	R:R:M564	R:R:R574	3.72	Yes	No	12	5	4
1052	R:R:M564	R:R:P575	5.03	Yes	No	12	5	3
1053	R:R:I576	R:R:R565	7.52	No	No	0	8	7
1054	R:R:R565	R:R:R738	17.06	No	No	0	7	4
1055	R:R:R565	R:R:R741	34.12	No	No	0	7	5
1056	R:R:P566	R:R:R738	5.76	No	No	0	8	4
1057	R:R:E568	R:R:T567	4.23	No	No	0	1	7
1058	R:R:P575	R:R:R574	5.76	No	No	12	3	4
1059	R:R:E582	R:R:I579	20.5	No	No	0	6	5
1060	R:R:K580	R:R:P647	5.02	No	Yes	0	6	9
1061	R:R:K580	R:R:L815	12.69	No	No	0	6	6
1062	R:R:K580	R:R:T819	9.01	No	No	0	6	8
1063	R:R:L581	R:R:Y816	9.38	No	No	0	8	5
1064	R:R:I644	R:R:W583	4.7	No	No	0	8	5
1065	R:R:I817	R:R:W587	5.87	No	No	0	5	5
1066	R:R:P591	R:R:V824	5.3	Yes	No	0	8	7
1067	R:R:I644	R:R:L592	8.56	No	No	0	8	6
1068	R:R:A595	R:R:T640	5.03	No	No	0	7	7
1069	R:R:A595	R:R:F641	4.16	No	No	0	7	7
1070	R:R:G598	R:R:Y637	10.14	No	Yes	0	7	8
1071	R:R:F634	R:R:I599	8.79	No	No	0	4	6
1072	R:R:I599	R:R:Y637	6.04	No	Yes	0	6	8
1073	R:R:T602	R:R:Y637	4.99	No	Yes	0	7	8
1074	R:R:L834	R:R:T602	7.37	No	No	0	8	7
1075	R:R:F604	R:R:T608	6.49	No	No	0	4	6
1076	R:R:F604	R:R:L846	4.87	No	No	0	4	6
1077	R:R:L630	R:R:V605	5.96	No	No	22	9	6
1078	R:R:V605	R:R:Y838	3.79	No	Yes	22	6	9
1079	R:R:L630	R:R:V606	4.47	No	No	0	9	5
1080	R:R:T608	R:R:V842	11.11	No	No	0	6	8
1081	R:R:F609	R:R:S626	5.28	No	No	22	8	8
1082	R:R:F609	R:R:Y838	9.28	No	Yes	22	8	9
1083	R:R:V610	R:R:Y627	3.79	No	No	0	4	7
1084	R:R:R611	R:R:Y612	12.35	No	No	0	4	5
1085	R:R:T615	R:R:Y612	4.99	Yes	No	0	9	5
1086	R:R:I845	R:R:Y612	4.84	No	No	0	8	5
1087	R:R:N613	R:R:R623	9.64	No	No	0	6	8
1088	R:R:N613	R:R:Y627	4.65	No	No	0	6	7
1089	R:R:D614	R:R:K619	4.15	No	No	0	5	7
1090	R:R:I617	R:R:T615	4.56	No	Yes	0	7	9
1091	R:R:N852	R:R:T615	10.24	No	Yes	0	9	9
1092	R:R:K619	R:R:R623	8.66	No	No	0	7	8
1093	A:A:Y354	R:R:K619	5.97	Yes	No	0	5	7
1094	R:R:A620	R:R:F781	5.55	No	Yes	0	9	9
1095	R:R:K841	R:R:S621	7.65	Yes	No	0	9	9
1096	R:R:E624	R:R:R623	4.65	No	No	0	6	8
1097	R:R:E624	R:R:R676	9.3	No	Yes	0	6	8
1098	R:R:E624	R:R:P696	14.15	No	No	0	6	6
1099	R:R:L625	R:R:T672	4.42	No	Yes	5	8	7
1100	R:R:K673	R:R:L625	7.05	No	No	0	9	8
1101	R:R:L625	R:R:T703	4.42	No	Yes	5	8	7
1102	R:R:S626	R:R:Y838	5.09	No	Yes	22	8	9
1103	R:R:L629	R:R:Y838	8.21	No	Yes	0	8	9
1104	R:R:L630	R:R:Y838	5.86	No	Yes	22	9	9
1105	R:R:I633	R:R:Y637	4.84	Yes	Yes	0	9	8
1106	R:R:I633	R:R:S666	4.64	Yes	No	0	9	7
1107	R:R:I633	R:R:L834	8.56	Yes	No	0	9	8
1108	R:R:F658	R:R:L635	6.09	Yes	No	0	6	6
1109	R:R:S831	R:R:Y637	7.63	No	Yes	0	5	8
1110	R:R:F658	R:R:T639	3.89	Yes	No	0	6	7
1111	R:R:L659	R:R:T639	4.42	No	No	0	8	7
1112	R:R:T640	R:R:T823	9.42	No	No	0	7	7
1113	R:R:S827	R:R:T640	4.8	No	No	0	9	7
1114	R:R:L642	R:R:L654	4.15	No	No	0	5	5
1115	R:R:F658	R:R:L642	4.87	Yes	No	0	6	5
1116	R:R:M643	R:R:R655	6.2	No	Yes	0	7	8
1117	R:R:P647	R:R:R655	7.21	Yes	Yes	0	9	8
1118	R:R:L744	R:R:P647	6.57	No	Yes	0	7	9
1119	R:R:D648	R:R:T651	4.34	No	No	0	5	6
1120	R:R:R655	R:R:T651	7.76	Yes	No	0	8	6
1121	R:R:C652	R:R:S725	5.16	No	No	0	9	5
1122	R:R:C652	R:R:C746	7.28	No	No	0	9	9
1123	R:R:L654	R:R:S653	4.5	No	Yes	0	5	5
1124	R:R:F718	R:R:S653	5.28	No	Yes	0	7	5
1125	R:R:C746	R:R:R655	5.57	No	Yes	0	9	8
1126	R:R:R656	R:R:W717	5	No	No	0	8	8
1127	R:R:R656	R:R:S752	7.91	No	No	0	8	6
1128	R:R:M663	R:R:V826	6.09	No	No	0	8	8
1129	R:R:Q710	R:R:S664	10.11	No	No	49	9	7
1130	R:R:S664	R:R:Y759	5.09	No	Yes	49	7	8
1131	R:R:I665	R:R:I707	7.36	No	No	0	7	7
1132	R:R:M791	R:R:Y667	5.99	No	Yes	0	9	6
1133	R:R:T794	R:R:Y667	11.24	No	Yes	0	8	6
1134	R:R:S833	R:R:Y667	5.09	No	Yes	0	7	6
1135	R:R:I787	R:R:L670	11.42	Yes	No	0	9	7
1136	R:R:L671	R:R:T766	7.37	No	No	0	8	4
1137	R:R:C767	R:R:L671	6.35	No	No	0	8	8
1138	R:R:L671	R:R:Y770	4.69	No	No	0	8	7
1139	R:R:Q699	R:R:T672	4.25	No	Yes	5	8	7
1140	R:R:I702	R:R:T672	4.56	No	Yes	0	6	7
1141	R:R:T672	R:R:T703	6.28	Yes	Yes	5	7	7
1142	R:R:K673	R:R:R676	3.71	No	Yes	0	9	8
1143	R:R:T674	R:R:Y770	3.75	No	No	0	9	7
1144	R:R:N675	R:R:R679	16.87	No	Yes	0	6	7
1145	R:R:N675	R:R:Y770	20.93	No	No	0	6	7
1146	R:R:R676	R:R:R679	4.26	Yes	Yes	5	8	7
1147	R:R:I680	R:R:R676	3.76	Yes	Yes	5	9	8
1148	R:R:I694	R:R:R676	3.76	Yes	Yes	5	7	8
1149	R:R:Q699	R:R:R676	23.36	No	Yes	5	8	8
1150	A:A:L353	R:R:R676	4.86	No	Yes	0	7	8
1151	R:R:F681	R:R:I677	3.77	Yes	No	0	9	9
1152	A:A:L353	R:R:I677	4.28	No	No	0	7	9
1153	R:R:K773	R:R:Y678	8.36	No	No	0	7	6
1154	R:R:T774	R:R:Y678	8.74	No	No	0	8	6
1155	R:R:P691	R:R:R679	5.76	Yes	Yes	5	7	7
1156	R:R:I694	R:R:R679	5.01	Yes	Yes	5	7	7
1157	R:R:Q699	R:R:R679	7.01	No	Yes	5	8	7
1158	R:R:F681	R:R:I680	5.02	Yes	Yes	5	9	9
1159	R:R:I680	R:R:I694	5.89	Yes	Yes	5	9	7
1160	A:A:N347	R:R:I680	4.25	No	Yes	0	7	9
1161	A:A:L348	R:R:I680	4.28	Yes	Yes	5	8	9
1162	R:R:F681	R:R:V777	13.11	Yes	Yes	5	9	8
1163	R:R:F681	R:R:P778	4.33	Yes	No	5	9	9
1164	R:R:F681	R:R:F781	7.5	Yes	Yes	5	9	9
1165	A:A:I344	R:R:F681	6.28	No	Yes	0	6	9
1166	A:A:L348	R:R:F681	4.87	Yes	Yes	5	8	9
1167	R:R:E682	R:R:K685	8.1	No	No	0	6	5
1168	R:R:E682	R:R:R686	8.14	No	No	0	6	6
1169	R:R:G684	R:R:Q683	4.93	No	Yes	0	7	5
1170	R:R:Q683	R:R:S687	7.22	Yes	No	0	5	4
1171	R:R:P691	R:R:Q683	15.79	Yes	Yes	0	7	5
1172	A:A:N347	R:R:Q683	3.96	No	Yes	0	7	5
1173	A:A:D193	R:R:R686	8.34	No	No	0	3	6
1174	A:A:T219	R:R:V688	6.35	No	No	0	8	6
1175	A:A:I343	R:R:V688	6.14	No	No	0	7	6
1176	R:R:I694	R:R:P691	5.08	Yes	Yes	5	7	7
1177	R:R:F693	R:R:S698	7.93	No	No	0	5	7
1178	A:A:C351	R:R:I694	4.91	Yes	Yes	0	4	7
1179	A:A:C351	R:R:P696	5.65	Yes	No	0	4	6
1180	R:R:L709	R:R:Y759	5.86	No	Yes	0	5	8
1181	R:R:Q710	R:R:Y759	9.02	No	Yes	49	9	8
1182	R:R:G713	R:R:V716	3.68	No	No	0	7	4
1183	R:R:F718	R:R:S723	3.96	No	No	0	7	8
1184	R:R:D721	R:R:H724	6.3	Yes	No	50	6	4
1185	R:R:D721	R:R:D747	3.99	Yes	No	50	6	5
1186	R:R:D747	R:R:H724	21.43	No	No	50	5	4
1187	R:R:L744	R:R:V727	4.47	No	No	0	7	4
1188	R:R:D728	R:R:Q730	11.75	Yes	Yes	27	6	3
1189	R:R:F729	R:R:V743	22.28	No	No	0	4	6
1190	R:R:F729	R:R:K745	27.3	No	No	0	4	7
1191	R:R:Q730	R:R:R741	5.84	Yes	No	0	3	5
1192	R:R:L735	R:R:R733	7.29	No	No	0	6	6
1193	R:R:R733	R:R:R741	11.73	No	No	0	6	5
1194	R:R:F739	R:R:P737	5.78	No	No	0	3	5
1195	R:R:S749	R:R:S752	6.52	No	No	0	8	6
1196	R:R:D750	R:R:F805	4.78	No	Yes	0	3	8
1197	R:R:F805	R:R:L753	3.65	Yes	Yes	0	8	7
1198	R:R:L753	R:R:L822	4.15	Yes	No	0	7	8
1199	R:R:F806	R:R:I754	6.28	No	No	0	6	5
1200	R:R:L757	R:R:W798	12.53	No	No	51	8	9
1201	R:R:F801	R:R:L757	3.65	Yes	No	51	9	8
1202	R:R:L763	R:R:Y759	10.55	No	Yes	0	9	8
1203	R:R:M761	R:R:M764	4.33	No	No	52	6	8
1204	R:R:C767	R:R:M791	4.86	No	No	0	8	9
1205	R:R:M791	R:R:T768	4.52	No	No	0	9	8
1206	R:R:T774	R:R:V777	4.76	No	Yes	0	8	8
1207	R:R:P778	R:R:V777	5.3	No	Yes	5	9	8
1208	R:R:F781	R:R:V777	3.93	Yes	Yes	5	9	8
1209	R:R:E779	R:R:T780	5.64	No	No	0	8	7
1210	R:R:F781	R:R:T780	7.78	Yes	No	0	9	7
1211	A:A:L348	R:R:F781	8.53	Yes	Yes	5	8	9
1212	R:R:E783	R:R:I787	6.83	No	Yes	0	9	9
1213	R:R:E783	R:R:L837	3.98	No	No	0	9	8
1214	R:R:E783	R:R:K841	4.05	No	Yes	0	9	9
1215	R:R:M836	R:R:T790	6.02	No	No	0	7	9
1216	R:R:I796	R:R:Y792	13.3	No	Yes	4	8	9
1217	R:R:T793	R:R:V832	7.93	No	No	0	8	7
1218	R:R:S829	R:R:T794	6.4	No	No	0	9	8
1219	R:R:F801	R:R:W798	11.02	Yes	No	51	9	9
1220	R:R:L799	X:X:?1	7.22	No	Yes	0	6	0
1221	R:R:F801	R:R:I802	3.77	Yes	No	0	9	7
1222	R:R:F801	R:R:F805	20.36	Yes	Yes	0	9	8
1223	R:R:F801	R:R:T821	3.89	Yes	No	0	9	8
1224	R:R:F801	R:R:L822	8.53	Yes	No	0	9	8
1225	R:R:F801	R:R:S825	7.93	Yes	No	0	9	8
1226	R:R:I802	X:X:?1	5.32	No	Yes	0	7	0
1227	R:R:P803	X:X:?1	17.14	No	Yes	0	9	0
1228	R:R:I804	R:R:T821	13.68	No	No	0	7	8
1229	R:R:F805	R:R:F806	7.5	Yes	No	0	8	6
1230	R:R:F805	R:R:Q818	28.11	Yes	No	0	8	6
1231	R:R:I817	R:R:T808	10.64	No	No	0	5	8
1232	R:R:Q810	R:R:S809	4.33	No	No	0	8	6
1233	R:R:D813	R:R:Y816	13.79	No	No	0	4	5
1234	R:R:K814	R:R:Q818	8.14	No	No	0	6	6
1235	R:R:M836	R:R:V832	4.56	No	No	0	7	7
1236	R:R:K841	R:R:Y838	4.78	Yes	Yes	0	9	9
1237	R:R:L846	R:R:V842	4.47	No	No	0	6	8
1238	R:R:F847	R:R:Y843	9.28	No	No	0	5	8
1239	R:R:H848	R:R:Y843	10.89	No	No	0	7	8
1240	R:R:I844	R:R:Q851	6.86	No	No	0	8	4
1241	R:R:I845	R:R:N852	12.74	No	No	0	8	9
1242	R:R:F847	R:R:L846	4.87	No	No	0	5	6
1243	R:R:E850	R:R:H848	3.69	No	No	0	6	7
1244	B:B:D254	G:G:K29	8.3	Yes	No	0	9	4
1245	B:B:N237	G:G:K32	25.18	No	No	0	5	5
1246	G:G:A39	G:G:D36	6.18	No	No	0	3	5
1247	B:B:D323	G:G:Y40	17.24	No	No	0	7	6
1248	B:B:M325	G:G:Y40	9.58	No	No	0	5	6
1249	B:B:R283	G:G:E42	4.65	No	No	0	9	1
1250	B:B:M325	G:G:H44	9.19	No	No	0	5	6
1251	B:B:N340	G:G:H44	7.65	Yes	No	0	9	6
1252	B:B:M325	G:G:K46	5.76	No	No	0	5	1
1253	B:B:R49	G:G:E47	11.63	No	No	0	7	3
1254	B:B:G41	B:B:V40	3.68	No	No	0	1	3
1255	B:B:D298	B:B:V40	5.84	No	No	0	9	3
1256	B:B:Q44	B:B:R42	10.51	No	No	0	4	2
1257	B:B:M45	B:B:W339	8.14	No	Yes	0	4	9
1258	B:B:N340	B:B:R46	7.23	Yes	No	0	9	5
1259	B:B:K337	B:B:T47	6.01	Yes	No	18	6	3
1260	B:B:T47	B:B:W339	4.85	No	Yes	18	3	9
1261	B:B:N340	B:B:R48	21.69	Yes	No	0	9	7
1262	B:B:R49	B:B:T87	9.06	No	No	0	7	5
1263	B:B:I338	B:B:R49	5.01	No	No	0	5	7
1264	B:B:K337	B:B:T50	15.02	Yes	No	0	6	3
1265	B:B:L51	B:B:W82	12.53	Yes	Yes	0	9	9
1266	B:B:L51	B:B:T87	4.42	Yes	No	0	9	5
1267	B:B:L336	B:B:L51	6.92	No	Yes	0	7	9
1268	B:B:I338	B:B:L51	4.28	No	Yes	0	5	9
1269	B:B:F335	B:B:R52	7.48	No	No	0	4	7
1270	B:B:H54	B:B:I58	11.93	Yes	No	0	9	9
1271	B:B:H54	B:B:S72	5.58	Yes	No	0	9	9
1272	B:B:H54	B:B:S74	5.58	Yes	No	0	9	9
1273	B:B:H54	B:B:I80	5.3	Yes	Yes	0	9	8
1274	B:B:D76	B:B:L55	4.07	No	No	0	9	6
1275	B:B:K57	B:B:Y59	15.53	No	Yes	23	9	8
1276	B:B:K57	B:B:W332	19.73	No	Yes	23	9	9
1277	B:B:I58	B:B:L336	4.28	No	No	0	9	7
1278	B:B:Q75	B:B:Y59	11.27	No	Yes	0	9	8
1279	B:B:W332	B:B:Y59	8.68	Yes	Yes	23	9	8
1280	A:A:C214	B:B:Y59	9.41	No	Yes	0	8	8
1281	B:B:L70	B:B:M61	7.07	No	No	0	5	6
1282	B:B:C317	B:B:M61	4.86	No	No	0	7	6
1283	B:B:H62	B:B:R150	11.28	No	No	0	6	6
1284	B:B:L70	B:B:W63	9.11	No	No	0	5	7
1285	B:B:S84	B:B:W63	4.94	No	No	0	5	7
1286	B:B:T321	B:B:W63	13.34	No	No	0	7	7
1287	B:B:G64	B:B:Y105	4.35	No	Yes	0	5	6
1288	B:B:D66	B:B:L69	6.79	No	No	0	8	5
1289	B:B:S67	B:B:T321	9.59	No	No	0	5	7
1290	B:B:R68	B:B:Y85	21.61	No	No	0	5	4
1291	B:B:L69	B:B:Y105	9.38	No	Yes	0	5	6
1292	B:B:L70	B:B:W82	5.69	No	Yes	0	5	9
1293	B:B:C103	B:B:V71	5.12	No	No	0	8	8
1294	B:B:V71	B:B:Y105	8.83	No	Yes	0	8	6
1295	B:B:D76	B:B:S74	8.83	No	No	0	9	9
1296	B:B:Q75	B:B:W99	8.76	No	Yes	0	9	9
1297	B:B:D76	B:B:K78	8.3	No	No	0	9	8
1298	B:B:K78	B:B:P94	10.04	No	No	0	8	5
1299	A:A:D26	B:B:K78	4.15	No	No	0	5	8
1300	B:B:I93	B:B:L79	4.28	Yes	No	0	7	7
1301	B:B:L79	B:B:L95	8.3	No	No	0	7	8
1302	B:B:I80	B:B:W82	8.22	Yes	Yes	54	8	9
1303	B:B:I80	B:B:K89	7.27	Yes	Yes	54	8	9
1304	A:A:L23	B:B:I80	4.28	No	Yes	0	5	8
1305	B:B:H91	B:B:I81	10.61	Yes	No	55	5	7
1306	B:B:I81	B:B:Y105	10.88	No	Yes	0	7	6
1307	B:B:I81	B:B:L126	4.28	No	No	55	7	5
1308	B:B:K89	B:B:W82	12.76	Yes	Yes	54	9	9
1309	B:B:D83	B:B:N88	9.42	No	Yes	0	8	7
1310	B:B:I338	B:B:S84	4.64	No	No	0	5	5
1311	B:B:N88	B:B:T86	10.24	Yes	No	0	7	6
1312	A:A:S16	B:B:K89	6.12	No	Yes	0	7	9
1313	A:A:I19	B:B:K89	8.72	No	Yes	0	9	9
1314	A:A:D20	B:B:K89	8.3	No	Yes	0	6	9
1315	B:B:H91	B:B:V90	9.69	Yes	No	0	5	5
1316	B:B:H91	B:B:L126	3.86	Yes	No	55	5	5
1317	B:B:H91	B:B:V133	4.15	Yes	No	0	5	4
1318	B:B:I93	B:B:P94	5.08	Yes	No	0	7	5
1319	B:B:I93	B:B:Y124	7.25	Yes	Yes	0	7	6
1320	B:B:I93	B:B:V133	10.75	Yes	No	0	7	4
1321	B:B:L95	B:B:V100	7.45	No	No	0	8	9
1322	B:B:E138	B:B:R96	6.98	No	No	0	6	6
1323	B:B:D118	B:B:S97	8.83	No	No	0	9	8
1324	B:B:S98	B:B:W99	6.18	No	Yes	0	8	9
1325	B:B:L117	B:B:W99	4.56	No	Yes	6	9	9
1326	A:A:F199	B:B:W99	18.04	Yes	Yes	6	6	9
1327	A:A:F215	B:B:W99	12.03	Yes	Yes	6	9	9
1328	B:B:C114	B:B:V100	6.83	No	No	0	8	9
1329	B:B:M101	B:B:S147	10.73	No	No	0	9	9
1330	B:B:A104	B:B:F151	4.16	No	Yes	0	7	9
1331	B:B:N110	B:B:S108	7.45	No	No	0	4	6
1332	B:B:D154	B:B:S108	8.83	No	No	0	6	6
1333	B:B:K127	B:B:N110	11.19	No	No	0	4	4
1334	B:B:D154	B:B:Y111	5.75	No	No	0	6	4
1335	B:B:V112	B:B:Y124	3.79	No	Yes	0	8	6
1336	B:B:A113	B:B:F151	4.16	No	Yes	0	9	9
1337	B:B:C114	B:B:Y124	5.38	No	Yes	0	8	6
1338	B:B:G115	B:B:L146	5.13	No	No	0	9	7
1339	A:A:I184	B:B:L117	5.71	No	No	6	8	9
1340	A:A:Q204	B:B:L117	3.99	Yes	No	6	9	9
1341	B:B:D118	B:B:I120	7	No	No	0	9	6
1342	A:A:G183	B:B:N119	5.09	No	No	0	8	9
1343	B:B:C121	B:B:L139	4.76	No	Yes	0	8	9
1344	B:B:C121	B:B:C149	3.64	No	No	15	8	8
1345	B:B:C121	B:B:T159	6.76	No	Yes	15	8	9
1346	B:B:S122	B:B:Y124	6.36	No	Yes	0	8	6
1347	B:B:I123	B:B:L139	4.28	Yes	Yes	0	6	9
1348	B:B:F151	B:B:I123	3.77	Yes	Yes	0	9	6
1349	B:B:I123	B:B:I171	4.42	Yes	No	0	6	6
1350	B:B:V135	B:B:Y124	5.05	No	Yes	0	4	6
1351	B:B:N125	B:B:T128	5.85	No	No	0	4	3
1352	B:B:N125	B:B:S136	5.96	No	No	0	4	4
1353	B:B:N132	B:B:R134	14.46	No	No	0	3	3
1354	B:B:L139	B:B:W169	27.33	Yes	Yes	0	9	8
1355	B:B:H142	B:B:T159	8.21	No	Yes	15	9	9
1356	B:B:H142	B:B:S161	12.55	No	No	0	9	9
1357	B:B:H142	B:B:W169	14.81	No	Yes	15	9	8
1358	B:B:D163	B:B:G144	5.03	Yes	No	0	9	8
1359	B:B:S147	B:B:Y145	6.36	No	Yes	0	9	8
1360	B:B:G162	B:B:Y145	5.79	No	Yes	0	9	8
1361	B:B:D186	B:B:Y145	9.2	No	Yes	0	9	8
1362	B:B:M188	B:B:Y145	10.78	No	Yes	0	8	8
1363	A:A:S206	B:B:Y145	5.09	No	Yes	0	8	8
1364	B:B:L146	B:B:S161	6.01	No	No	0	7	9
1365	B:B:C148	B:B:L190	4.76	No	No	0	6	5
1366	B:B:C149	B:B:T159	6.76	No	Yes	15	8	9
1367	B:B:L192	B:B:R150	4.86	No	No	0	5	6
1368	B:B:F151	B:B:I157	6.28	Yes	No	0	9	7
1369	B:B:L152	B:B:Q156	3.99	Yes	No	0	3	5
1370	B:B:L152	B:B:L192	6.92	Yes	No	0	3	5
1371	B:B:L152	B:B:V213	4.47	Yes	No	0	3	4
1372	B:B:D170	B:B:N155	5.39	No	No	0	9	3
1373	B:B:I171	B:B:N155	5.66	No	No	0	6	3
1374	B:B:E172	B:B:N155	7.89	No	No	0	6	3
1375	B:B:L168	B:B:Q156	3.99	No	No	0	6	5
1376	B:B:I157	B:B:T159	4.56	No	Yes	0	7	9
1377	B:B:L192	B:B:V158	4.47	No	No	0	5	5
1378	B:B:F199	B:B:V158	7.87	No	No	0	9	5
1379	B:B:T159	B:B:W169	7.28	Yes	Yes	15	9	8
1380	B:B:L190	B:B:S160	9.01	No	No	0	5	6
1381	B:B:D163	B:B:S161	4.42	Yes	No	0	9	9
1382	B:B:D163	B:B:T165	7.23	Yes	No	0	9	7
1383	B:B:G185	B:B:T164	3.64	No	No	0	5	6
1384	B:B:T165	B:B:T181	6.28	No	No	0	7	2
1385	B:B:C166	B:B:F180	4.19	No	Yes	0	8	7
1386	B:B:A167	B:B:W169	3.89	No	Yes	15	4	8
1387	B:B:A167	B:B:Q176	6.06	No	No	15	4	4
1388	B:B:L168	B:B:T177	4.42	No	No	13	6	4
1389	B:B:L168	B:B:T178	7.37	No	No	13	6	4
1390	B:B:Q176	B:B:W169	10.95	No	Yes	15	4	8
1391	B:B:D170	B:B:T173	4.34	No	No	0	9	5
1392	B:B:D170	B:B:T177	4.34	No	No	0	9	4
1393	B:B:Q175	B:B:T173	9.92	No	No	0	4	5
1394	B:B:T177	B:B:T178	4.71	No	No	13	4	4
1395	B:B:F180	B:B:T178	10.38	Yes	No	13	7	4
1396	B:B:F180	B:B:F199	8.57	Yes	No	13	7	9
1397	B:B:F180	B:B:W211	11.02	Yes	Yes	13	7	8
1398	B:B:H183	B:B:S201	6.97	Yes	No	13	9	9
1399	B:B:A203	B:B:H183	4.39	No	Yes	0	8	9
1400	B:B:H183	B:B:S207	5.58	Yes	No	0	9	5
1401	B:B:H183	B:B:K209	15.72	Yes	Yes	13	9	6
1402	B:B:H183	B:B:W211	8.46	Yes	Yes	13	9	8
1403	B:B:D205	B:B:T184	4.34	No	No	0	9	3
1404	B:B:S207	B:B:T184	4.8	No	No	0	5	3
1405	B:B:C204	B:B:D186	4.67	No	No	0	7	9
1406	B:B:S201	B:B:V187	6.46	No	No	0	9	9
1407	B:B:M188	B:B:N230	5.61	No	No	0	8	9
1408	A:A:K210	B:B:M188	4.32	Yes	No	0	9	8
1409	B:B:I232	B:B:S189	6.19	No	No	0	8	7
1410	B:B:F234	B:B:S191	5.28	Yes	No	0	5	8
1411	B:B:A193	B:B:F234	4.16	No	Yes	0	4	5
1412	B:B:D195	B:B:R197	17.87	No	No	0	5	5
1413	B:B:L198	B:B:L210	6.92	No	No	0	3	5
1414	B:B:L198	B:B:R219	3.64	No	No	0	3	5
1415	B:B:F199	B:B:W211	6.01	No	Yes	13	9	8
1416	B:B:F234	B:B:V200	3.93	Yes	No	0	5	6
1417	B:B:F241	B:B:V200	14.42	Yes	No	0	6	6
1418	B:B:S201	B:B:W211	7.41	No	Yes	13	9	8
1419	B:B:C204	B:B:D228	4.67	No	No	56	7	9
1420	A:A:K210	B:B:C204	4.85	Yes	No	56	9	7
1421	B:B:K209	B:B:W211	12.76	Yes	Yes	13	6	8
1422	B:B:C218	B:B:K209	9.7	No	Yes	0	5	6
1423	B:B:L210	B:B:Q220	10.65	No	No	0	5	7
1424	B:B:D212	B:B:E215	14.29	Yes	No	0	9	3
1425	B:B:E215	B:B:M217	9.47	No	No	0	3	3
1426	B:B:C218	B:B:T221	5.07	No	No	0	5	7
1427	B:B:Q220	B:B:R219	11.68	No	No	0	7	5
1428	B:B:F222	B:B:F241	6.43	Yes	Yes	9	8	6
1429	B:B:F222	B:B:F253	6.43	Yes	Yes	9	8	6
1430	B:B:G224	B:B:T223	3.64	No	No	0	6	2
1431	B:B:E226	B:B:H225	9.85	Yes	Yes	9	3	9
1432	B:B:H225	B:B:I229	3.98	Yes	No	0	9	7
1433	B:B:H225	B:B:S245	11.16	Yes	No	9	9	9
1434	B:B:H225	B:B:T249	5.48	Yes	Yes	9	9	6
1435	B:B:H225	B:B:R251	11.28	Yes	Yes	9	9	8
1436	B:B:D247	B:B:E226	7.8	No	Yes	9	9	3
1437	B:B:E226	B:B:T249	9.88	Yes	Yes	9	3	6
1438	B:B:E226	B:B:R251	4.65	Yes	Yes	9	3	8
1439	B:B:D247	B:B:S227	5.89	No	No	0	9	6
1440	A:A:K210	B:B:D228	4.15	Yes	No	56	9	9
1441	B:B:D246	B:B:N230	5.39	No	No	0	9	9
1442	B:B:N230	B:B:T274	5.85	No	No	0	9	8
1443	B:B:F241	B:B:I232	3.77	Yes	No	0	6	8
1444	B:B:C233	B:B:F278	9.78	No	Yes	0	3	7
1445	B:B:F235	B:B:P236	7.22	Yes	No	0	6	7
1446	B:B:A240	B:B:F235	5.55	No	Yes	0	6	6
1447	B:B:F235	B:B:F278	9.65	Yes	Yes	0	6	7
1448	B:B:F235	B:B:G282	4.52	Yes	No	0	6	9
1449	B:B:L255	B:B:N239	4.12	No	No	0	6	2
1450	B:B:F241	B:B:T243	3.89	Yes	No	9	6	8
1451	B:B:F241	B:B:F253	9.65	Yes	Yes	9	6	6
1452	B:B:A242	B:B:F278	4.16	No	Yes	0	4	7
1453	B:B:F253	B:B:T243	7.78	Yes	No	9	6	8
1454	B:B:G244	B:B:I273	5.29	No	No	0	5	6
1455	B:B:S245	B:B:T249	4.8	No	Yes	9	9	6
1456	B:B:D246	B:B:G272	5.03	No	No	0	9	4
1457	B:B:D247	B:B:T249	8.67	No	Yes	9	9	6
1458	B:B:A248	B:B:H266	5.85	No	No	0	5	4
1459	B:B:A248	B:B:Y289	4	No	Yes	0	5	7
1460	B:B:R251	B:B:T249	5.17	Yes	Yes	9	8	6
1461	B:B:F253	B:B:R251	6.41	Yes	Yes	9	6	8
1462	B:B:E260	B:B:R251	4.65	No	Yes	0	6	8
1463	B:B:R251	B:B:T263	11.64	Yes	No	0	8	1
1464	B:B:L252	B:B:L261	8.3	No	No	0	7	5
1465	B:B:L252	B:B:Y264	11.72	No	No	0	7	5
1466	B:B:A257	B:B:Q259	4.55	No	No	0	7	6
1467	B:B:L285	B:B:Y264	8.21	No	No	0	6	5
1468	B:B:A302	B:B:Y264	4	No	No	0	2	5
1469	B:B:H266	B:B:I269	6.63	No	No	0	4	4
1470	B:B:I269	B:B:Y289	4.84	No	Yes	0	4	7
1471	B:B:C271	B:B:G272	3.92	No	No	0	5	4
1472	B:B:C271	B:B:Y289	4.03	No	Yes	0	5	7
1473	B:B:I273	B:B:Y289	13.3	No	Yes	0	6	7
1474	B:B:R314	B:B:T274	6.47	No	No	0	8	8
1475	B:B:G319	B:B:S277	3.71	No	No	0	5	5
1476	B:B:F278	B:B:L285	4.87	Yes	No	0	7	6
1477	B:B:S279	B:B:S281	4.89	No	No	0	9	9
1478	B:B:G282	B:B:S281	3.71	No	No	0	9	9
1479	B:B:R283	B:B:S281	6.59	No	No	0	9	9
1480	B:B:L284	B:B:L286	4.15	No	No	57	5	7
1481	B:B:L284	B:B:V296	4.47	No	No	57	5	5
1482	B:B:L285	B:B:W297	10.25	No	No	0	6	8
1483	B:B:L286	B:B:V296	4.47	No	No	57	7	5
1484	B:B:C294	B:B:G288	3.92	No	No	0	5	7
1485	B:B:W297	B:B:Y289	7.72	No	Yes	0	8	7
1486	B:B:D290	B:B:R314	19.06	No	No	0	6	8
1487	B:B:N293	B:B:N295	5.45	No	No	0	5	6
1488	B:B:N293	B:B:V307	4.43	No	No	0	5	3
1489	B:B:C294	B:B:L308	4.76	No	No	0	5	7
1490	B:B:C294	B:B:V315	5.12	No	No	0	5	7
1491	B:B:N295	B:B:W297	5.65	No	No	0	6	8
1492	B:B:D298	B:B:K301	16.59	No	No	0	9	5
1493	B:B:D303	B:B:R304	8.34	No	No	0	2	5
1494	B:B:L308	B:B:W339	15.94	No	Yes	0	7	9
1495	B:B:H311	B:B:S331	16.74	No	No	18	9	9
1496	B:B:D333	B:B:H311	16.39	Yes	No	18	9	9
1497	B:B:H311	B:B:K337	14.41	No	Yes	18	9	6
1498	B:B:N313	B:B:W332	6.78	No	Yes	0	7	9
1499	B:B:D333	B:B:N313	5.39	Yes	No	0	9	7
1500	B:B:R314	B:B:W332	28.99	No	Yes	0	8	9
1501	B:B:T329	B:B:V315	4.76	No	No	0	8	7
1502	B:B:S331	B:B:V315	8.08	No	No	0	9	7
1503	B:B:S316	B:B:W332	4.94	No	Yes	0	9	9
1504	B:B:C317	B:B:G330	3.92	No	No	0	7	5
1505	B:B:A326	B:B:N340	4.69	No	Yes	0	7	9
1506	B:B:T329	B:B:W339	7.28	No	Yes	0	8	9
1507	B:B:D333	B:B:S331	4.42	Yes	No	18	9	9
1508	A:A:H213	B:B:W332	8.46	No	Yes	23	8	9
1509	A:A:W258	B:B:W332	4.69	Yes	Yes	23	5	9
1510	B:B:D333	B:B:F335	13.14	Yes	No	0	9	4
1511	B:B:F335	B:B:K337	3.72	No	Yes	0	4	6
1512	B:B:K337	B:B:W339	9.28	Yes	Yes	18	6	9
1513	A:A:K10	A:A:S6	10.71	No	No	0	3	8
1514	A:A:D20	A:A:K17	8.3	No	No	0	6	4
1515	A:A:E25	A:A:R21	20.93	No	No	0	4	4
1516	A:A:E28	A:A:R24	12.79	No	No	0	4	4
1517	A:A:D26	A:A:K29	4.15	No	No	0	5	2
1518	A:A:E33	A:A:H188	6.15	No	Yes	6	6	3
1519	A:A:E33	A:A:Y195	12.35	No	Yes	6	6	4
1520	A:A:E33	A:A:K197	24.3	No	Yes	6	6	7
1521	A:A:F196	A:A:V34	5.24	Yes	No	0	7	5
1522	A:A:T219	A:A:V34	4.76	No	No	0	8	5
1523	A:A:K197	A:A:K35	8.62	Yes	No	6	7	9
1524	A:A:F199	A:A:K35	6.2	Yes	No	6	6	9
1525	A:A:K35	A:A:V218	6.07	No	No	0	9	9
1526	A:A:F196	A:A:L36	4.87	Yes	No	0	7	7
1527	A:A:L36	A:A:M198	4.24	No	Yes	0	7	7
1528	A:A:L37	A:A:L39	5.54	No	Yes	0	9	9
1529	A:A:F215	A:A:L37	7.31	Yes	No	0	9	9
1530	A:A:I221	A:A:L37	8.56	No	No	0	7	9
1531	A:A:L38	A:A:M198	4.24	No	Yes	0	9	7
1532	A:A:F223	A:A:L39	10.96	No	Yes	0	9	9
1533	A:A:I253	A:A:L39	4.28	No	Yes	0	8	9
1534	A:A:G40	A:A:K46	6.97	No	Yes	0	9	9
1535	A:A:K46	A:A:S44	4.59	Yes	No	0	9	9
1536	A:A:G45	A:A:T48	5.46	No	No	58	9	9
1537	A:A:G45	A:A:N269	5.09	No	Yes	58	9	9
1538	A:A:K46	A:A:N47	5.6	Yes	No	0	9	9
1539	A:A:D200	A:A:K46	6.91	No	Yes	0	9	9
1540	A:A:N269	A:A:T48	5.85	Yes	No	58	9	9
1541	A:A:C224	A:A:I49	6.55	No	No	59	7	7
1542	A:A:F267	A:A:I49	10.05	Yes	No	59	9	7
1543	A:A:T187	A:A:V50	4.76	No	No	0	7	7
1544	A:A:N331	A:A:Q52	3.96	No	No	0	8	9
1545	A:A:F189	A:A:M53	12.44	Yes	No	19	9	9
1546	A:A:M53	A:A:V332	4.56	No	Yes	19	9	7
1547	A:A:I56	A:A:V332	4.61	No	Yes	0	8	7
1548	A:A:G183	A:A:Q204	6.58	No	Yes	0	8	9
1549	A:A:I184	A:A:Q204	4.12	No	Yes	6	8	9
1550	A:A:D200	A:A:V185	4.38	No	No	0	9	5
1551	A:A:E186	A:A:H188	16	No	Yes	6	9	3
1552	A:A:E186	A:A:K197	5.4	No	Yes	6	9	7
1553	A:A:E186	A:A:F199	4.66	No	Yes	6	9	6
1554	A:A:M198	A:A:T187	4.52	Yes	No	0	7	7
1555	A:A:H188	A:A:Y195	23.96	Yes	Yes	6	3	4
1556	A:A:H188	A:A:K197	5.24	Yes	Yes	6	3	7
1557	A:A:F189	A:A:F196	13.93	Yes	Yes	0	9	7
1558	A:A:F189	A:A:M198	6.22	Yes	Yes	0	9	7
1559	A:A:F189	A:A:V332	3.93	Yes	Yes	19	9	7
1560	A:A:D191	A:A:K192	12.44	No	No	19	5	4
1561	A:A:D191	A:A:V332	5.84	No	Yes	19	5	7
1562	A:A:D191	A:A:F336	4.78	No	No	19	5	8
1563	A:A:K192	A:A:Q333	6.78	No	No	0	4	5
1564	A:A:F336	A:A:K192	16.13	No	No	19	8	4
1565	A:A:F196	A:A:L194	8.53	Yes	No	0	7	4
1566	A:A:F196	A:A:V335	3.93	Yes	No	0	7	8
1567	A:A:F196	A:A:V339	3.93	Yes	No	0	7	8
1568	A:A:F199	A:A:K197	11.17	Yes	Yes	6	6	7
1569	A:A:F199	A:A:F215	7.5	Yes	Yes	6	6	9
1570	A:A:Q204	A:A:W211	4.38	Yes	Yes	0	9	9
1571	A:A:E207	A:A:K209	5.4	No	No	0	9	8
1572	A:A:E207	A:A:K210	5.4	No	Yes	0	9	9
1573	A:A:K209	A:A:R208	6.19	No	No	0	8	9
1574	A:A:R208	A:A:W211	5	No	Yes	0	9	9
1575	A:A:R208	A:A:S252	5.27	No	No	0	9	7
1576	A:A:I212	A:A:W211	5.87	No	Yes	0	9	9
1577	A:A:F215	A:A:W211	6.01	Yes	Yes	0	9	9
1578	A:A:F259	A:A:I212	7.54	Yes	No	0	9	9
1579	A:A:C214	A:A:H213	7.37	No	No	0	8	8
1580	A:A:H213	A:A:W258	6.35	No	Yes	23	8	5
1581	A:A:E216	A:A:W258	4.36	No	Yes	0	8	5
1582	A:A:F259	A:A:I221	6.28	Yes	No	0	9	7
1583	A:A:I221	A:A:I264	5.89	No	Yes	0	7	6
1584	A:A:F267	A:A:I222	7.54	Yes	No	0	9	7
1585	A:A:F223	A:A:F250	18.22	No	Yes	10	9	9
1586	A:A:F223	A:A:L266	3.65	No	Yes	10	9	9
1587	A:A:C224	A:A:F267	4.19	No	Yes	59	7	9
1588	A:A:S246	A:A:V225	4.85	No	No	10	9	7
1589	A:A:F307	A:A:V225	10.49	Yes	No	10	8	7
1590	A:A:A226	A:A:K270	8.03	No	No	0	8	9
1591	A:A:L227	A:A:L268	4.15	No	No	0	7	8
1592	A:A:F274	A:A:L227	8.53	No	No	0	8	7
1593	A:A:I303	A:A:L227	11.42	No	No	0	8	7
1594	A:A:K270	A:A:S228	9.18	No	No	0	9	9
1595	A:A:D229	A:A:R242	13.1	No	No	0	8	9
1596	A:A:F274	A:A:Y230	7.22	No	Yes	0	8	9
1597	A:A:K277	A:A:Y230	14.33	No	Yes	0	9	9
1598	A:A:L283	A:A:Y230	8.21	No	Yes	0	7	9
1599	A:A:C286	A:A:Y230	5.38	No	Yes	0	6	9
1600	A:A:D231	A:A:K277	8.3	No	No	0	9	9
1601	A:A:L232	A:A:R242	17.01	No	No	0	8	9
1602	A:A:D237	A:A:E238	9.09	No	No	0	8	4
1603	A:A:E238	A:A:M240	6.77	No	No	0	4	6
1604	A:A:K248	A:A:M240	5.76	No	No	0	5	6
1605	A:A:H244	A:A:N241	16.58	No	No	0	4	9
1606	A:A:M243	A:A:Y287	5.99	No	Yes	0	8	8
1607	A:A:H244	A:A:K248	3.93	No	No	0	4	5
1608	A:A:H244	A:A:Y287	5.44	No	Yes	0	4	8
1609	A:A:F307	A:A:S246	3.96	Yes	No	10	8	9
1610	A:A:M247	A:A:Y287	7.18	No	Yes	0	6	8
1611	A:A:F307	A:A:M247	6.22	Yes	No	0	8	6
1612	A:A:F250	A:A:I264	3.77	Yes	Yes	10	9	6
1613	A:A:F250	A:A:L266	9.74	Yes	Yes	10	9	9
1614	A:A:F250	A:A:F307	11.79	Yes	Yes	10	9	8
1615	A:A:F250	A:A:L310	3.65	Yes	No	0	9	4
1616	A:A:F250	A:A:I319	5.02	Yes	Yes	10	9	6
1617	A:A:D251	A:A:N255	10.77	No	No	0	5	8
1618	A:A:D251	A:A:L310	4.07	No	No	0	5	4
1619	A:A:F259	A:A:I253	5.02	Yes	No	0	9	8
1620	A:A:C254	A:A:N255	4.72	No	No	0	5	8
1621	A:A:C254	A:A:K317	4.85	No	No	0	5	7
1622	A:A:N255	A:A:R312	8.44	No	No	0	8	5
1623	A:A:F259	A:A:N256	7.25	Yes	No	0	9	8
1624	A:A:K257	A:A:W258	10.44	No	Yes	0	5	5
1625	A:A:R313	A:A:T260	16.82	No	No	0	4	3
1626	A:A:K317	A:A:T260	6.01	No	No	0	7	3
1627	A:A:N346	A:A:T262	8.77	No	No	0	4	8
1628	A:A:S263	A:A:V342	8.08	No	No	0	7	6
1629	A:A:I264	A:A:K317	7.27	Yes	No	0	6	7
1630	A:A:I264	A:A:I319	4.42	Yes	Yes	10	6	6
1631	A:A:F307	A:A:L266	4.87	Yes	Yes	10	8	9
1632	A:A:L266	A:A:T321	5.9	Yes	No	10	9	4
1633	A:A:F267	A:A:T324	5.19	Yes	No	0	9	9
1634	A:A:F267	A:A:F334	7.5	Yes	Yes	0	9	4
1635	A:A:F267	A:A:V335	3.93	Yes	No	0	9	8
1636	A:A:F323	A:A:L268	3.65	No	No	0	5	8
1637	A:A:N269	A:A:T324	10.24	Yes	No	0	9	9
1638	A:A:D272	A:A:K271	8.3	No	No	0	9	5
1639	A:A:F323	A:A:K271	6.2	No	No	0	5	5
1640	A:A:D272	A:A:S326	8.83	No	No	0	9	9
1641	A:A:E275	A:A:E276	3.81	No	No	0	5	5
1642	A:A:E275	A:A:Y296	4.49	No	No	0	5	4
1643	A:A:K279	A:A:R280	9.9	No	No	0	3	3
1644	A:A:P282	A:A:T284	5.25	No	No	0	5	4
1645	A:A:L283	A:A:Y290	5.86	No	No	0	7	7
1646	A:A:C286	A:A:Y287	10.75	No	Yes	0	6	8
1647	A:A:Y287	A:A:Y302	9.93	Yes	Yes	60	8	6
1648	A:A:Q306	A:A:Y287	19.16	No	Yes	60	5	8
1649	A:A:E289	A:A:P288	7.86	No	No	0	6	6
1650	A:A:E298	A:A:Y290	5.61	No	No	0	5	7
1651	A:A:Y290	A:A:Y302	10.92	No	Yes	0	7	6
1652	A:A:E298	A:A:G292	4.91	No	No	0	5	7
1653	A:A:S293	A:A:T295	4.8	No	No	0	3	5
1654	A:A:E298	A:A:S293	4.31	No	No	0	5	3
1655	A:A:T295	A:A:Y296	4.99	No	No	61	5	4
1656	A:A:E297	A:A:T295	9.88	No	No	61	4	5
1657	A:A:E297	A:A:Y296	37.04	No	No	61	4	4
1658	A:A:Q306	A:A:Y302	15.78	No	Yes	60	5	6
1659	A:A:I303	A:A:Q306	10.98	No	No	0	8	5
1660	A:A:E308	A:A:Q304	12.74	No	No	10	3	5
1661	A:A:Q304	A:A:T321	7.09	No	No	10	5	4
1662	A:A:E308	A:A:I319	12.3	No	Yes	10	3	6
1663	A:A:E308	A:A:T321	8.47	No	No	10	3	4
1664	A:A:K314	A:A:N311	4.2	No	No	0	3	7
1665	A:A:I319	A:A:N311	8.5	Yes	No	0	6	7
1666	A:A:D315	A:A:T316	7.23	No	No	0	1	3
1667	A:A:E318	A:A:Y320	16.83	No	Yes	0	4	8
1668	A:A:E318	A:A:K345	12.15	No	No	0	4	5
1669	A:A:A338	A:A:Y320	5.34	No	Yes	0	7	8
1670	A:A:D341	A:A:Y320	9.2	No	Yes	0	7	8
1671	A:A:F334	A:A:H322	32.81	Yes	No	0	4	9
1672	A:A:N331	A:A:T324	5.85	No	No	0	8	9
1673	A:A:C325	A:A:N331	11.02	No	No	0	7	8
1674	A:A:D328	A:A:K330	13.83	No	No	0	9	4
1675	A:A:A338	A:A:F334	4.16	No	Yes	0	7	4
1676	A:A:F336	A:A:T340	7.78	No	No	0	8	6
1677	A:A:D341	A:A:K345	9.68	No	No	0	7	5
1678	A:A:N346	A:A:V342	4.43	No	No	0	4	6
1679	A:A:K345	A:A:Y354	9.55	No	Yes	0	5	5
1680	A:A:L348	A:A:Y354	4.69	Yes	Yes	0	8	5
1681	A:A:K349	A:A:Y354	5.97	No	Yes	0	4	5
1682	S:S:I89	S:S:Y414	3.63	No	No	0	9	8
1683	S:S:I599	S:S:Y637	3.63	Yes	Yes	0	6	8
1684	S:S:I845	S:S:Y612	3.63	No	No	0	8	5
1685	S:S:I772	S:S:Y792	3.63	No	No	0	8	9
1686	R:R:I410	R:R:Y414	3.63	No	No	0	7	8
1687	B:B:I123	B:B:Y111	3.63	Yes	No	0	6	4
1688	A:A:I265	A:A:Y320	3.63	No	Yes	0	9	8
1689	S:S:N461	S:S:R474	3.62	Yes	No	0	5	4
1690	B:B:A60	B:B:C103	3.61	No	No	0	7	8
1691	R:R:M764	R:R:Y667	3.59	No	Yes	0	8	6
1692	B:B:Y85	G:G:K46	3.58	No	No	0	4	1
1693	S:S:D426	S:S:R425	3.57	No	No	0	4	3
1694	B:B:D83	B:B:R68	3.57	No	No	0	8	5
1695	S:S:P586	S:S:S585	3.56	No	No	0	4	7
1696	S:S:P696	S:S:S695	3.56	No	No	0	6	7
1697	R:R:P56	R:R:S110	3.56	No	No	0	5	4
1698	S:S:G102	S:S:I45	3.53	No	No	0	9	4
1699	S:S:G493	S:S:I492	3.53	No	No	0	9	7
1700	S:S:G632	S:S:I665	3.53	No	No	0	8	7
1701	S:S:P778	S:S:V777	3.53	No	Yes	0	9	8
1702	R:R:G102	R:R:I45	3.53	No	No	0	9	4
1703	R:R:G433	R:R:I99	3.53	No	Yes	0	3	5
1704	R:R:G493	R:R:I477	3.53	No	No	0	9	7
1705	B:B:G202	B:B:I232	3.53	No	No	0	6	8
1706	S:S:L762	S:S:Y759	3.52	No	Yes	0	4	8
1707	S:S:P472	S:S:T464	3.5	No	No	0	3	3
1708	R:R:Q402	R:R:R338	3.5	Yes	No	0	6	5
1709	R:R:Q551	R:R:R570	3.5	No	No	0	8	6
1710	R:R:P591	R:R:T820	3.5	Yes	No	0	8	8
1711	R:R:P591	R:R:T823	3.5	Yes	No	0	8	7
1712	R:R:P616	R:R:T615	3.5	No	Yes	0	8	9
1713	S:S:G152	S:S:M416	3.49	No	Yes	0	8	6
1714	S:S:E295	S:S:R299	3.49	No	No	0	2	3
1715	S:S:G835	S:S:M839	3.49	No	No	0	3	3
1716	R:R:G59	R:R:K71	3.49	No	No	0	3	5
1717	R:R:E148	R:R:R149	3.49	No	No	0	4	3
1718	R:R:G535	R:R:K534	3.49	No	No	0	7	6
1719	R:R:G835	R:R:M839	3.49	No	No	0	3	3
1720	B:B:G53	B:B:K89	3.49	No	Yes	0	9	9
1721	B:B:N125	B:B:Y111	3.49	No	No	0	4	4
1722	A:A:G202	A:A:K46	3.49	No	Yes	0	9	9
1723	R:R:D731	R:R:Y562	3.45	No	Yes	0	6	3
1724	S:S:C520	S:S:S521	3.44	No	No	0	9	8
1725	A:A:C351	R:R:S695	3.44	Yes	No	0	4	7
1726	B:B:C166	B:B:S160	3.44	No	No	0	8	6
1727	S:S:C636	S:S:V826	3.42	No	Yes	0	6	8
1728	R:R:A183	R:R:S159	3.42	No	Yes	0	7	9
1729	R:R:A285	R:R:S226	3.42	No	No	0	4	7
1730	R:R:C636	R:R:V826	3.42	No	No	0	6	8
1731	R:R:G660	R:R:L756	3.42	No	No	0	6	7
1732	A:A:A31	R:R:S689	3.42	No	No	0	4	5
1733	R:R:G835	R:R:L834	3.42	No	No	0	3	8
1734	A:A:A41	A:A:S44	3.42	No	No	0	8	9
1735	S:S:A412	S:S:V198	3.39	No	No	0	9	9
1736	S:S:I256	S:S:P257	3.39	Yes	No	0	5	4
1737	S:S:I576	S:S:P577	3.39	Yes	No	0	8	3
1738	S:S:I644	S:S:P591	3.39	No	No	0	8	8
1739	R:R:A156	R:R:V161	3.39	No	Yes	0	6	4
1740	R:R:I174	R:R:P175	3.39	No	Yes	0	6	8
1741	R:R:I450	R:R:P175	3.39	No	Yes	0	7	8
1742	R:R:A280	R:R:V221	3.39	No	No	0	8	7
1743	R:R:I576	R:R:P577	3.39	No	No	0	8	3
1744	B:B:G144	B:B:N119	3.39	No	No	0	8	9
1745	B:B:A231	B:B:V276	3.39	No	No	0	5	6
1746	B:B:A287	B:B:V276	3.39	No	No	0	6	6
1747	R:R:E682	R:R:Y678	3.37	No	No	0	6	6
1748	S:S:D442	S:S:G443	3.35	No	No	0	4	5
1749	S:S:D731	S:S:G742	3.35	Yes	No	0	6	7
1750	R:R:D46	R:R:G47	3.35	No	No	0	4	9
1751	R:R:K65	R:R:P66	3.35	No	No	0	1	1
1752	R:R:D245	R:R:G246	3.35	No	No	0	4	7
1753	R:R:M536	R:R:P537	3.35	No	No	0	6	4
1754	B:B:D205	B:B:G185	3.35	No	No	0	9	5
1755	B:B:K280	B:B:P236	3.35	No	No	0	1	7
1756	S:S:T820	X:X:?1	3.3	No	Yes	0	8	0
1757	S:S:G395	S:S:Q396	3.29	No	No	0	3	1
1758	S:S:G660	S:S:Q710	3.29	No	No	0	6	9
1759	R:R:G742	R:R:Q730	3.29	No	Yes	0	7	3
1760	S:S:L522	S:S:P523	3.28	No	No	0	4	5
1761	R:R:L522	R:R:P523	3.28	No	No	0	4	5
1762	R:R:L590	R:R:P591	3.28	No	Yes	0	4	8
1763	S:S:E528	S:S:G527	3.27	Yes	No	0	5	9
1764	S:S:C746	S:S:I748	3.27	No	No	0	9	5
1765	R:R:C746	R:R:I748	3.27	No	No	0	9	5
1766	B:B:C250	B:B:I273	3.27	No	No	0	8	6
1767	S:S:S695	S:S:S698	3.26	No	No	0	7	7
1768	R:R:S811	S:S:S811	3.26	No	No	53	8	8
1769	S:S:A81	S:S:I410	3.25	No	No	0	7	7
1770	S:S:A297	S:S:I269	3.25	No	Yes	0	4	4
1771	S:S:A419	S:S:I450	3.25	No	Yes	0	8	7
1772	S:S:A588	S:S:I644	3.25	No	No	0	8	8
1773	R:R:A800	S:S:I804	3.25	No	No	0	7	7
1774	R:R:A412	R:R:I177	3.25	No	No	0	9	7
1775	R:R:A297	R:R:I269	3.25	No	No	0	4	4
1776	R:R:A419	R:R:I450	3.25	No	No	0	8	7
1777	R:R:A830	R:R:I633	3.25	No	Yes	0	8	9
1778	R:R:A771	R:R:I787	3.25	No	Yes	0	9	9
1779	A:A:I19	B:B:A92	3.25	No	No	0	9	6
1780	A:A:A220	A:A:I265	3.25	No	No	0	8	9
1781	A:A:A299	A:A:I278	3.25	No	No	0	7	6
1782	S:S:C795	S:S:M764	3.24	No	No	0	6	8
1783	R:R:C538	R:R:M536	3.24	No	No	0	9	6
1784	R:R:C795	R:R:M761	3.24	No	No	52	6	6
1785	R:R:C795	R:R:M764	3.24	No	No	52	6	8
1786	R:R:S242	R:R:V248	3.23	No	No	0	7	7
1787	R:R:S825	R:R:V797	3.23	No	No	0	8	8
1788	B:B:S279	B:B:V320	3.23	No	No	0	9	7
1789	S:S:D721	S:S:P722	3.22	Yes	No	0	6	7
1790	S:S:A771	S:S:M791	3.22	No	Yes	0	9	9
1791	R:R:A459	R:R:M339	3.22	No	No	0	4	3
1792	R:R:D721	R:R:P722	3.22	Yes	No	0	6	7
1793	B:B:A328	B:B:M61	3.22	No	No	0	5	6
1794	A:A:A245	A:A:M240	3.22	No	No	0	9	6
1795	S:S:F84	S:S:R88	3.21	No	No	0	7	8
1796	S:S:A206	S:S:K241	3.21	No	No	0	6	5
1797	S:S:V213	S:S:V248	3.21	No	No	0	6	7
1798	R:R:V151	R:R:V441	3.21	No	No	0	4	3
1799	B:B:V320	B:B:V327	3.21	No	No	0	7	6
1800	S:S:R342	S:S:R346	3.2	No	No	0	4	3
1801	S:S:R733	S:S:R741	3.2	No	Yes	0	6	5
1802	R:R:T808	S:S:S811	3.2	No	No	53	8	8
1803	R:R:S833	R:R:T790	3.2	No	No	0	7	9
1804	R:R:S811	R:R:T808	3.2	No	No	53	8	8
1805	B:B:S275	B:B:T274	3.2	No	No	0	8	8
1806	S:S:T223	S:S:V235	3.17	No	No	0	5	5
1807	S:S:C767	S:S:L670	3.17	No	No	0	8	7
1808	S:S:C767	S:S:L671	3.17	No	No	0	8	8
1809	S:S:C715	S:S:L711	3.17	No	No	0	3	4
1810	R:R:T108	R:R:V161	3.17	No	Yes	0	6	4
1811	R:R:T303	R:R:V327	3.17	No	Yes	0	6	3
1812	R:R:T615	R:R:V618	3.17	Yes	No	0	9	9
1813	R:R:C767	R:R:L670	3.17	No	No	0	8	7
1814	R:R:C755	R:R:L751	3.17	No	No	0	4	3
1815	R:R:C795	R:R:L799	3.17	No	No	0	6	6
1816	R:R:P526	R:R:Q525	3.16	No	No	0	6	1
1817	S:S:A328	S:S:L294	3.15	No	No	0	7	5
1818	S:S:A668	S:S:L706	3.15	No	No	0	9	5
1819	R:R:A328	R:R:L294	3.15	No	Yes	0	7	5
1820	R:R:A668	R:R:L706	3.15	No	No	0	9	5
1821	S:S:T567	S:S:T571	3.14	Yes	No	36	7	6
1822	S:S:E783	S:S:P786	3.14	Yes	No	0	9	5
1823	S:S:T790	S:S:T793	3.14	No	Yes	0	9	8
1824	R:R:E543	R:R:P544	3.14	No	No	0	4	4
1825	S:S:A459	S:S:N461	3.13	No	Yes	0	4	5
1826	B:B:C271	B:B:D291	3.11	No	No	0	5	8
1827	A:A:C325	A:A:D328	3.11	No	No	0	7	9
1828	S:S:I633	S:S:S666	3.1	Yes	No	0	9	7
1829	S:S:I633	S:S:S833	3.1	Yes	No	0	9	7
1830	R:R:I702	R:R:S698	3.1	No	No	0	6	7
1831	R:R:A399	R:R:D397	3.09	No	No	0	2	3
1832	B:B:A193	B:B:D195	3.09	No	No	0	4	5
1833	A:A:A235	A:A:D237	3.09	No	No	0	5	8
1834	S:S:I845	S:S:V618	3.07	No	No	0	8	9
1835	R:R:I282	R:R:V221	3.07	No	No	0	7	7
1836	R:R:I665	R:R:V628	3.07	No	No	0	7	6
1837	R:R:M663	R:R:S760	3.07	No	No	0	8	8
1838	A:A:K32	R:R:S687	3.06	No	No	0	4	4
1839	S:S:C524	S:S:Q525	3.05	No	Yes	0	9	1
1840	S:S:I633	S:S:T602	3.04	Yes	No	0	9	7
1841	S:S:I817	S:S:T820	3.04	No	No	0	5	8
1842	R:R:C388	R:R:E392	3.04	No	No	0	8	7
1843	R:R:M839	R:R:V605	3.04	No	No	0	3	6
1844	R:R:I707	R:R:T703	3.04	No	Yes	0	7	7
1845	G:G:K29	G:G:V30	3.04	No	No	0	4	8
1846	A:A:I56	A:A:T329	3.04	No	No	0	8	9
1847	R:R:A319	R:R:E73	3.02	No	Yes	0	1	2
1848	S:S:F194	S:S:G443	3.01	No	No	0	7	5
1849	S:S:M643	S:S:T819	3.01	No	No	0	7	8
1850	S:S:M791	S:S:T790	3.01	Yes	No	0	9	9
1851	R:R:F55	R:R:G53	3.01	Yes	No	0	9	7
1852	R:R:F194	R:R:G443	3.01	Yes	No	0	7	5
1853	R:R:F455	R:R:G457	3.01	Yes	No	0	9	6
1854	R:R:M643	R:R:T823	3.01	No	No	0	7	7
1855	B:B:F180	B:B:G216	3.01	Yes	No	0	7	4
1856	B:B:F234	B:B:G238	3.01	Yes	No	0	5	7
1857	S:S:R517	S:S:W218	3	No	Yes	0	1	9
1858	S:S:K337	S:S:T496	3	Yes	No	0	5	5
1859	S:S:L594	S:S:S827	3	No	No	0	4	9
1860	S:S:L629	S:S:S666	3	No	No	0	8	7
1861	S:S:L661	S:S:S664	3	No	No	0	6	7
1862	S:S:G742	S:S:R741	3	No	Yes	0	7	5
1863	R:R:G247	R:R:R214	3	No	No	0	5	4
1864	R:R:K337	R:R:T496	3	No	No	0	5	5
1865	R:R:L594	R:R:S827	3	No	No	0	4	9
1866	R:R:L649	R:R:S723	3	No	No	0	3	8
1867	B:B:L318	B:B:S277	3	No	No	0	6	5
1868	B:B:L284	B:B:S279	3	No	No	0	5	9
1869	A:A:L273	A:A:S228	3	No	No	0	6	9
1870	A:A:L249	A:A:S252	3	No	No	0	8	7
1871	S:S:Y478	S:S:Y489	2.98	No	Yes	0	4	5
1872	S:S:L630	S:S:V606	2.98	No	No	0	9	5
1873	S:S:L822	S:S:V826	2.98	No	Yes	0	8	8
1874	R:R:L712	R:R:V716	2.98	No	No	0	1	4
1875	R:R:L815	R:R:V743	2.98	No	No	0	6	6
1876	R:R:L828	R:R:V797	2.98	No	No	0	6	8
1877	A:A:S16	B:B:N88	2.98	No	Yes	0	7	7
1878	A:A:L39	A:A:V201	2.98	Yes	No	0	9	9
1879	S:S:L106	S:S:T121	2.95	No	No	0	5	3
1880	S:S:L659	S:S:T639	2.95	No	No	0	8	7
1881	S:S:L700	S:S:T703	2.95	No	Yes	0	5	7
1882	B:B:L318	B:B:T329	2.95	No	No	0	6	8
1883	S:S:D112	S:S:S160	2.94	No	No	0	4	5
1884	S:S:I239	S:S:I250	2.94	No	No	0	4	6
1885	R:R:D185	R:R:S233	2.94	No	No	0	4	4
1886	R:R:I804	R:R:I817	2.94	No	No	0	7	5
1887	R:R:I154	R:R:M82	2.92	No	No	0	8	8
1888	R:R:D112	R:R:V161	2.92	Yes	Yes	0	4	4
1889	R:R:N569	R:R:T567	2.92	No	No	0	4	7
1890	B:B:D212	B:B:V213	2.92	Yes	No	0	9	4
1891	S:S:I748	S:S:K745	2.91	No	No	0	5	7
1892	R:R:I617	R:R:K841	2.91	No	Yes	0	7	9
1893	L:L:?1	R:R:G158	2.9	Yes	No	0	0	4
1894	B:B:G324	G:G:Y40	2.9	No	No	0	9	6
1895	B:B:G109	B:B:Y105	2.9	No	Yes	0	5	6
1896	S:S:Q699	S:S:S698	2.89	Yes	No	0	8	7
1897	R:R:D442	R:R:T444	2.89	No	No	0	4	3
1898	B:B:D322	B:B:T65	2.89	No	No	0	1	1
1899	B:B:D163	B:B:T143	2.89	Yes	No	0	9	5
1900	S:S:P575	S:S:R574	2.88	No	No	0	3	4
1901	R:R:P66	R:R:R111	2.88	No	No	0	1	5
1902	R:R:P472	R:R:R474	2.88	No	No	0	3	4
1903	S:S:E63	S:S:S62	2.87	No	No	0	1	1
1904	S:S:K373	S:S:K387	2.87	No	No	0	4	1
1905	R:R:Q407	R:R:V341	2.87	Yes	No	0	7	6
1906	A:A:K29	A:A:K32	2.87	No	No	0	2	4
1907	A:A:E318	A:A:S263	2.87	No	No	0	4	7
1908	S:S:I503	S:S:L501	2.85	No	Yes	0	4	7
1909	S:S:I599	S:S:L603	2.85	Yes	No	0	6	2
1910	R:R:I49	R:R:L51	2.85	Yes	No	0	6	7
1911	R:R:I174	R:R:L126	2.85	No	No	0	6	4
1912	R:R:I269	R:R:L273	2.85	No	No	0	4	5
1913	R:R:I714	R:R:L711	2.85	No	No	0	6	4
1914	R:R:I748	R:R:L753	2.85	No	Yes	0	5	7
1915	A:A:I278	A:A:L283	2.85	No	No	0	6	7
1916	S:S:Q124	S:S:T121	2.83	No	No	0	7	3
1917	S:S:Q252	S:S:T275	2.83	No	No	0	6	3
1918	S:S:Q818	S:S:T808	2.83	No	No	0	6	8
1919	S:S:L834	S:S:M839	2.83	No	No	0	8	3
1920	R:R:Q118	R:R:T121	2.83	No	No	0	5	3
1921	R:R:L659	R:R:M663	2.83	No	No	0	8	8
1922	B:B:L300	B:B:M262	2.83	No	No	0	6	4
1923	S:S:E392	S:S:T389	2.82	Yes	No	0	7	6
1924	S:S:K580	S:S:L744	2.82	No	No	0	6	7
1925	B:B:E130	B:B:T128	2.82	No	No	0	3	3
1926	R:R:G807	S:S:W587	2.81	No	No	0	8	5
1927	R:R:C428	R:R:R431	2.79	Yes	No	0	7	3
1928	R:R:C542	R:R:R529	2.79	No	No	0	9	6
1929	S:S:P566	S:S:Y550	2.78	No	Yes	0	8	7
1930	S:S:A415	S:S:F455	2.77	No	Yes	0	8	9
1931	S:S:L635	S:S:L661	2.77	No	No	0	6	6
1932	S:S:A638	S:S:F658	2.77	No	No	0	6	6
1933	R:R:A415	R:R:F455	2.77	No	Yes	0	8	9
1934	R:R:A415	R:R:F465	2.77	No	No	0	8	8
1935	B:B:K280	G:G:D36	2.77	No	No	0	1	5
1936	B:B:A106	B:B:F151	2.77	No	Yes	0	6	9
1937	B:B:A208	B:B:F222	2.77	No	Yes	9	6	8
1938	B:B:A208	B:B:F241	2.77	No	Yes	9	6	6
1939	B:B:L210	B:B:L255	2.77	No	No	0	5	6
1940	A:A:A300	A:A:F323	2.77	No	No	0	5	5
1941	A:A:D309	A:A:K314	2.77	No	No	0	4	3
1942	R:R:L353	R:R:N390	2.75	Yes	No	0	6	4
1943	S:S:I492	S:S:Q479	2.74	No	Yes	0	7	8
1944	R:R:H500	R:R:T496	2.74	No	No	0	1	5
1945	S:S:E401	S:S:I318	2.73	No	No	0	5	4
1946	B:B:E138	B:B:I120	2.73	No	No	0	6	6
1947	S:S:D354	S:S:L353	2.71	No	No	0	4	6
1948	B:B:D212	B:B:L198	2.71	Yes	No	0	9	3
1949	S:S:E73	S:S:K72	2.7	No	No	0	2	4
1950	S:S:P523	S:S:W540	2.7	No	No	0	5	8
1951	R:R:E264	R:R:K261	2.7	Yes	No	45	3	3
1952	R:R:E264	R:R:K267	2.7	Yes	No	45	3	2
1953	R:R:E488	R:R:K490	2.7	No	No	0	4	5
1954	S:S:C249	S:S:Y220	2.69	No	Yes	0	9	9
1955	B:B:D254	B:B:N239	2.69	Yes	No	0	9	2
1956	A:A:C305	A:A:Y302	2.69	No	Yes	0	3	6
1957	S:S:A278	S:S:Y220	2.67	No	Yes	0	7	9
1958	S:S:A422	S:S:Y449	2.67	No	Yes	0	4	4
1959	R:R:A278	R:R:Y220	2.67	No	Yes	0	7	9
1960	R:R:A422	R:R:Y449	2.67	No	Yes	0	4	4
1961	B:B:A287	B:B:Y289	2.67	No	Yes	0	6	7
1962	R:R:H424	R:R:I99	2.65	Yes	Yes	0	5	5
1963	A:A:E239	A:A:L234	2.65	No	No	0	4	8
1964	R:R:E467	R:R:N466	2.63	No	No	0	4	7
1965	S:S:F455	S:S:V453	2.62	Yes	No	0	9	7
1966	S:S:F465	S:S:V453	2.62	No	No	0	8	7
1967	S:S:F604	S:S:V842	2.62	No	No	0	4	8
1968	R:R:F408	R:R:V198	2.62	Yes	No	0	7	9
1969	R:R:F465	R:R:V198	2.62	No	No	0	8	9
1970	R:R:F238	R:R:V210	2.62	No	No	0	7	6
1971	R:R:R214	R:R:V248	2.62	No	No	0	4	7
1972	R:R:H371	R:R:K386	2.62	No	No	0	3	3
1973	R:R:F609	R:R:V842	2.62	No	No	0	8	8
1974	B:B:R283	B:B:V40	2.62	No	No	0	9	3
1975	R:R:D245	R:R:E244	2.6	No	No	0	4	4
1976	A:A:D9	A:A:E8	2.6	No	No	0	4	4
1977	B:B:R150	B:B:T102	2.59	No	No	0	6	8
1978	S:S:H724	S:S:L649	2.57	No	No	0	4	3
1979	A:A:E238	A:A:E239	2.54	No	No	0	4	4
1980	R:R:D368	R:R:H371	2.52	No	No	0	3	3
1981	S:S:I519	S:S:R517	2.51	No	No	0	5	1
1982	S:S:F634	S:S:I599	2.51	No	Yes	0	4	6
1983	S:S:F718	S:S:I657	2.51	Yes	No	0	7	5
1984	S:S:I694	S:S:R679	2.51	No	No	0	7	7
1985	S:S:F704	S:S:I707	2.51	No	No	0	4	7
1986	R:R:F172	R:R:I127	2.51	No	No	0	6	4
1987	R:R:F704	R:R:I707	2.51	No	No	0	4	7
1988	B:B:I43	B:B:R46	2.51	No	No	0	3	5
1989	B:B:I93	B:B:R134	2.51	Yes	No	0	7	3
1990	A:A:T190	A:A:Y195	2.5	No	Yes	0	3	4
1991	S:S:E403	S:S:H77	2.46	Yes	No	0	5	6
1992	R:R:V826	R:R:W798	2.45	No	No	0	8	9
1993	S:S:F172	S:S:L126	2.44	No	No	0	6	4
1994	R:R:L120	S:S:F172	2.44	No	No	0	5	6
1995	S:S:F641	S:S:L592	2.44	Yes	No	0	7	6
1996	R:R:F641	R:R:L592	2.44	No	No	0	7	6
1997	R:R:F634	R:R:L603	2.44	No	No	0	4	2
1998	B:B:F234	B:B:L255	2.44	Yes	No	0	5	6
1999	S:S:L427	S:S:R437	2.43	No	No	0	3	3
2000	B:B:F235	B:B:N237	2.42	Yes	No	0	6	5
2001	B:B:F292	B:B:N313	2.42	No	No	0	4	7
2002	R:R:D731	R:R:F729	2.39	No	No	0	6	4
2003	B:B:D258	B:B:F222	2.39	No	Yes	0	7	8
2004	B:B:D312	B:B:F292	2.39	No	No	0	5	4
2005	A:A:K32	A:A:Y195	2.39	No	Yes	0	4	4
2006	A:A:D337	A:A:F334	2.39	No	Yes	0	4	4
2007	S:S:D354	S:S:R357	2.38	No	No	0	4	3
2008	R:R:D553	R:R:R554	2.38	No	No	0	7	7
2009	B:B:D212	B:B:R214	2.38	Yes	No	0	9	9
2010	S:S:Q252	S:S:R271	2.34	No	No	0	6	3
2011	S:S:F805	S:S:Q818	2.34	No	No	0	8	6
2012	R:R:Q551	R:R:R554	2.34	No	No	0	8	7
2013	S:S:N277	S:S:Y220	2.33	No	Yes	0	6	9
2014	S:S:E624	S:S:R623	2.33	No	No	0	6	8
2015	R:R:N277	R:R:Y220	2.33	No	Yes	0	6	9
2016	B:B:E130	B:B:R129	2.33	No	No	0	3	3
2017	S:S:K531	S:S:W540	2.32	No	No	0	6	8
2018	S:S:H500	S:S:R502	2.26	No	No	0	1	5
2019	S:S:F847	S:S:H848	2.26	No	No	0	5	7
2020	R:R:D497	R:R:W495	2.23	No	Yes	0	2	5
2021	A:A:R21	A:A:R24	2.13	No	No	0	4	4
2022	S:S:G102	S:S:G47	2.11	No	No	0	9	9
2023	S:S:G52	S:S:G53	2.11	No	No	0	8	7
2024	S:S:G59	S:S:G68	2.11	No	No	0	3	4
2025	S:S:G61	S:S:G68	2.11	No	No	0	2	4
2026	S:S:G246	S:S:G247	2.11	No	No	0	7	5
2027	R:R:G61	R:R:G68	2.11	No	No	0	2	4
2028	B:B:G115	B:B:G116	2.11	No	No	0	9	9
2029	S:S:G430	S:S:P429	2.03	No	No	0	4	2
2030	R:R:G584	R:R:P586	2.03	No	No	0	4	4
2031	R:R:R517	R:R:W218	2	No	Yes	0	1	9
2032	S:S:C636	S:S:G662	1.96	No	No	0	6	6
2033	R:R:C636	R:R:G662	1.96	No	No	0	6	6
2034	S:S:A262	S:S:G263	1.95	No	No	0	2	1
2035	S:S:A601	S:S:G598	1.95	No	No	0	5	7
2036	S:S:A771	S:S:G788	1.95	No	No	0	9	8
2037	R:R:A237	R:R:G234	1.95	No	No	0	4	7
2038	R:R:A601	R:R:G598	1.95	No	No	0	5	7
2039	B:B:A140	B:B:G141	1.95	No	No	0	5	5
2040	A:A:A30	A:A:G27	1.95	No	No	0	3	5
2041	A:A:A41	A:A:G42	1.95	No	No	0	8	7
2042	R:R:W587	R:R:Y816	1.93	No	No	0	5	5
2043	S:S:C435	S:S:P436	1.88	No	No	0	6	3
2044	S:S:C560	S:S:P561	1.88	Yes	No	0	9	4
2045	R:R:C428	R:R:P429	1.88	Yes	No	0	7	2
2046	R:R:C435	R:R:P436	1.88	No	No	0	6	3
2047	R:R:A690	R:R:P691	1.87	No	Yes	0	5	7
2048	B:B:A106	B:B:P107	1.87	No	No	0	6	6
2049	B:B:A193	B:B:P194	1.87	No	No	0	4	4
2050	S:S:G650	S:S:S653	1.86	No	No	0	3	5
2051	R:R:G64	R:R:S62	1.86	No	No	0	1	1
2052	R:R:G632	R:R:S666	1.86	No	No	0	8	7
2053	R:R:G650	R:R:S653	1.86	No	Yes	0	3	5
2054	B:B:G77	B:B:S98	1.86	No	No	0	8	8
2055	S:S:G53	S:S:V153	1.84	No	No	0	7	6
2056	S:S:G713	S:S:V716	1.84	No	No	0	7	4
2057	R:R:G598	R:R:V597	1.84	No	No	0	7	2
2058	A:A:G202	A:A:V201	1.84	No	No	0	9	9
2059	S:S:G572	S:S:T567	1.82	No	Yes	36	1	7
2060	S:S:G572	S:S:T571	1.82	No	No	36	1	6
2061	R:R:G304	R:R:T303	1.82	No	No	0	3	6
2062	R:R:G547	R:R:T546	1.82	No	No	0	5	5
2063	R:R:G572	R:R:T567	1.82	No	No	0	1	7
2064	B:B:G131	B:B:T128	1.82	No	No	0	4	3
2065	B:B:A73	B:B:C103	1.81	No	No	0	9	8
2066	S:S:A206	S:S:A237	1.79	No	No	0	6	4
2067	R:R:A800	S:S:A800	1.79	No	No	0	7	7
2068	R:R:A206	R:R:A237	1.79	No	No	0	6	4
2069	B:B:A299	G:G:A33	1.79	No	No	0	5	7
2070	R:R:P462	R:R:S456	1.78	No	No	0	1	5
2071	R:R:P586	R:R:S585	1.78	No	No	0	4	7
2072	A:A:P282	A:A:S281	1.78	No	No	0	5	7
2073	S:S:G395	S:S:I394	1.76	No	Yes	0	3	5
2074	R:R:I804	S:S:G807	1.76	No	No	0	7	8
2075	R:R:G417	R:R:I89	1.76	No	No	0	9	9
2076	R:R:G788	R:R:I787	1.76	No	Yes	0	8	9
2077	S:S:G417	S:S:M416	1.75	No	Yes	0	9	6
2078	S:S:G758	S:S:M761	1.75	No	Yes	0	5	6
2079	S:S:P778	S:S:T780	1.75	No	No	0	9	7
2080	R:R:P737	R:R:T734	1.75	No	No	0	5	4
2081	R:R:G758	R:R:M761	1.75	No	No	0	5	6
2082	B:B:P107	B:B:T65	1.75	No	No	0	6	1
2083	S:S:G535	S:S:K534	1.74	No	No	0	7	6
2084	R:R:G64	R:R:K65	1.74	No	No	0	1	1
2085	R:R:G75	R:R:K74	1.74	No	Yes	0	5	5
2086	R:R:G622	R:R:K673	1.74	No	No	0	9	9
2087	B:B:G182	B:B:K209	1.74	No	Yes	0	6	6
2088	S:S:C746	S:S:S725	1.72	No	No	0	9	5
2089	S:S:A278	S:S:S222	1.71	No	No	0	7	8
2090	S:S:A588	S:S:S585	1.71	No	No	0	8	7
2091	S:S:G650	S:S:L649	1.71	No	No	0	3	3
2092	S:S:G660	S:S:L756	1.71	No	No	0	6	7
2093	S:S:A697	S:S:S695	1.71	No	No	0	3	7
2094	S:S:G713	S:S:L712	1.71	No	No	0	7	1
2095	R:R:G660	R:R:L659	1.71	No	No	0	6	8
2096	R:R:G662	R:R:L661	1.71	No	No	0	6	6
2097	B:B:V327	G:G:C41	1.71	No	No	0	6	7
2098	A:A:G27	B:B:L55	1.71	No	No	0	5	6
2099	B:B:A56	B:B:S74	1.71	No	No	0	7	9
2100	B:B:G174	B:B:L139	1.71	No	Yes	0	4	9
2101	S:S:A156	S:S:V161	1.7	No	Yes	0	6	4
2102	S:S:G457	S:S:N461	1.7	No	Yes	0	6	5
2103	S:S:G460	S:S:N461	1.7	No	Yes	0	5	5
2104	S:S:A669	S:S:V628	1.7	No	No	0	7	6
2105	S:S:A784	S:S:V777	1.7	No	Yes	0	9	8
2106	R:R:A669	R:R:V628	1.7	No	No	0	7	6
2107	B:B:A305	B:B:V296	1.7	No	No	0	4	5
2108	B:B:A309	B:B:V307	1.7	No	No	0	3	3
2109	S:S:M536	S:S:P537	1.68	No	No	0	6	4
2110	S:S:A645	S:S:T651	1.68	No	No	0	7	6
2111	S:S:D648	S:S:G650	1.68	No	No	0	5	3
2112	S:S:A668	S:S:T703	1.68	No	Yes	0	9	7
2113	S:S:A669	S:S:T703	1.68	No	Yes	0	7	7
2114	S:S:M839	S:S:P840	1.68	No	No	0	3	9
2115	R:R:A668	R:R:T703	1.68	No	Yes	0	9	7
2116	R:R:M839	R:R:P840	1.68	No	No	0	3	9
2117	B:B:A206	B:B:T223	1.68	No	No	0	4	2
2118	R:R:K785	R:R:P786	1.67	No	No	0	9	5
2119	S:S:E63	S:S:G64	1.64	No	No	0	1	1
2120	R:R:L96	R:R:P97	1.64	No	No	0	9	8
2121	R:R:L515	R:R:P516	1.64	No	Yes	0	4	8
2122	R:R:G527	R:R:Q551	1.64	No	No	0	9	8
2123	R:R:G660	R:R:Q710	1.64	No	No	0	6	9
2124	R:R:G742	R:R:Q732	1.64	No	No	0	7	6
2125	B:B:G141	B:B:Q176	1.64	No	No	0	5	4
2126	B:B:E260	B:B:G224	1.64	No	No	0	6	6
2127	A:A:E43	A:A:G42	1.64	No	No	0	9	7
2128	A:A:E216	A:A:G217	1.64	No	No	0	8	6
2129	S:S:N461	S:S:P462	1.63	Yes	No	0	5	1
2130	S:S:S749	S:S:S752	1.63	No	No	0	8	6
2131	R:R:N98	R:R:P97	1.63	No	No	0	8	8
2132	R:R:N461	R:R:P462	1.63	Yes	No	0	5	1
2133	R:R:S687	R:R:S689	1.63	No	No	0	4	5
2134	A:A:N294	A:A:P282	1.63	No	No	0	4	5
2135	S:S:C67	S:S:K65	1.62	No	No	0	9	1
2136	S:S:S242	S:S:V210	1.62	No	Yes	0	7	6
2137	S:S:S242	S:S:V248	1.62	No	No	0	7	7
2138	S:S:A300	S:S:I269	1.62	No	Yes	0	4	4
2139	S:S:S829	S:S:V826	1.62	No	Yes	0	9	8
2140	R:R:A85	R:R:I410	1.62	No	No	0	8	7
2141	R:R:A300	R:R:I269	1.62	No	No	0	4	4
2142	R:R:C557	R:R:K530	1.62	No	Yes	0	9	8
2143	R:R:A588	R:R:I644	1.62	No	No	0	8	8
2144	B:B:S97	B:B:V100	1.62	No	No	0	8	9
2145	B:B:A140	B:B:I120	1.62	No	No	0	5	6
2146	R:R:D439	R:R:P440	1.61	No	No	0	1	3
2147	R:R:D736	R:R:P737	1.61	No	No	0	3	5
2148	B:B:D153	B:B:P107	1.61	No	No	0	5	6
2149	S:S:S253	S:S:T223	1.6	No	No	0	4	5
2150	S:S:V605	S:S:V842	1.6	No	No	0	6	8
2151	S:S:V765	S:S:V769	1.6	No	No	0	4	5
2152	R:R:V716	R:R:V720	1.6	No	No	0	4	4
2153	B:B:S265	B:B:T263	1.6	No	No	0	2	1
2154	A:A:S326	A:A:T327	1.6	No	No	0	9	9
2155	S:S:T50	S:S:V150	1.59	No	No	0	4	5
2156	S:S:G433	S:S:H424	1.59	No	No	0	3	5
2157	S:S:T556	S:S:V552	1.59	No	No	0	4	6
2158	R:R:C372	R:R:L374	1.59	No	No	0	8	3
2159	S:S:A215	S:S:L499	1.58	No	Yes	0	5	7
2160	S:S:A363	S:S:L353	1.58	No	No	0	3	6
2161	S:S:A487	S:S:L482	1.58	No	No	0	3	3
2162	R:R:A215	R:R:L499	1.58	No	No	48	5	7
2163	R:R:A215	R:R:L501	1.58	No	No	48	5	7
2164	R:R:A363	R:R:L353	1.58	No	Yes	0	3	6
2165	G:G:A34	G:G:L37	1.58	No	No	0	6	7
2166	B:B:A299	B:B:L300	1.58	No	No	0	5	6
2167	R:R:E646	R:R:P647	1.57	No	Yes	0	5	9
2168	B:B:T179	B:B:T181	1.57	No	No	0	4	2
2169	R:R:A784	R:R:N782	1.56	No	No	0	9	9
2170	A:A:A12	B:B:N88	1.56	No	Yes	0	4	7
2171	A:A:A226	A:A:N269	1.56	No	Yes	0	8	9
2172	R:R:I657	R:R:S653	1.55	No	Yes	0	5	5
2173	A:A:I285	A:A:S281	1.55	No	No	0	3	7
2174	R:R:A812	R:R:D813	1.54	No	No	0	3	4
2175	B:B:A257	B:B:D254	1.54	No	Yes	0	7	9
2176	B:B:A299	B:B:D298	1.54	No	No	0	5	9
2177	R:R:H848	R:R:P849	1.53	No	No	0	7	8
2178	S:S:K745	S:S:V726	1.52	No	No	0	7	3
2179	S:S:I772	S:S:T768	1.52	No	No	0	8	8
2180	R:R:Q810	S:S:A812	1.52	No	No	0	8	3
2181	R:R:K373	R:R:V385	1.52	No	No	0	4	1
2182	R:R:I772	R:R:T768	1.52	No	No	0	8	8
2183	R:R:K773	R:R:V769	1.52	No	No	0	7	5
2184	A:A:K51	A:A:V50	1.52	No	No	0	9	7
2185	A:A:C351	A:A:E350	1.52	Yes	No	0	4	4
2186	R:R:F84	R:R:G343	1.51	No	No	0	7	5
2187	R:R:A487	R:R:E325	1.51	No	Yes	0	3	4
2188	R:R:A363	R:R:E364	1.51	No	No	0	3	5
2189	R:R:A645	R:R:E646	1.51	No	No	0	7	5
2190	A:A:A7	A:A:E8	1.51	No	No	0	1	4
2191	S:S:G622	S:S:R623	1.5	No	No	0	9	8
2192	S:S:L654	S:S:S653	1.5	No	No	0	5	5
2193	S:S:L751	S:S:S749	1.5	No	No	0	3	8
2194	R:R:G61	R:R:R111	1.5	No	No	0	2	5
2195	R:R:L751	R:R:S749	1.5	No	No	0	3	8
2196	R:R:L753	R:R:S752	1.5	Yes	No	0	7	6
2197	R:R:G776	R:R:R775	1.5	No	No	0	7	9
2198	A:A:G27	A:A:R24	1.5	No	No	0	5	4
2199	A:A:K349	A:A:T316	1.5	No	No	0	4	3
2200	S:S:L846	S:S:V842	1.49	No	No	0	6	8
2201	R:R:L700	R:R:V628	1.49	No	No	0	5	6
2202	A:A:L234	A:A:V233	1.49	No	No	0	8	4
2203	R:R:N98	R:R:V432	1.48	No	No	0	8	3
2204	S:S:I617	S:S:I844	1.47	No	No	0	7	8
2205	B:B:L152	B:B:T196	1.47	Yes	No	0	3	1
2206	A:A:D9	A:A:S6	1.47	No	No	0	4	8
2207	A:A:I55	A:A:I56	1.47	No	No	0	8	8
2208	S:S:N454	S:S:T464	1.46	No	No	0	5	3
2209	R:R:N466	R:R:T464	1.46	No	No	0	7	3
2210	R:R:I503	R:R:M506	1.46	No	No	0	4	7
2211	R:R:N569	R:R:T571	1.46	No	No	0	4	6
2212	R:R:D721	R:R:V720	1.46	Yes	No	0	6	4
2213	R:R:D728	R:R:V726	1.46	Yes	No	0	6	3
2214	R:R:G547	R:R:Y548	1.45	No	No	0	5	8
2215	R:R:K534	S:S:K534	1.44	No	No	0	6	6
2216	R:R:I318	R:R:L322	1.43	No	No	0	4	3
2217	R:R:I578	R:R:L744	1.43	No	No	0	5	7
2218	R:R:I714	R:R:L756	1.43	No	No	0	6	7
2219	A:A:I278	A:A:N294	1.42	No	No	0	6	4
2220	S:S:E568	S:S:T567	1.41	No	Yes	0	1	7
2221	R:R:E274	R:R:T275	1.41	No	No	0	4	3
2222	R:R:K387	R:R:L374	1.41	No	No	0	1	3
2223	A:A:E261	A:A:T260	1.41	No	No	0	4	3
2224	A:A:E261	A:A:T262	1.41	No	No	0	4	8
2225	S:S:D266	S:S:I269	1.4	No	Yes	0	3	4
2226	S:S:C715	S:S:F718	1.4	No	Yes	0	3	7
2227	R:R:K448	R:R:N452	1.4	No	No	0	3	4
2228	S:S:H305	S:S:S276	1.39	Yes	No	0	3	7
2229	S:S:P561	S:S:Y562	1.39	No	No	0	4	3
2230	R:R:A638	R:R:F658	1.39	No	Yes	0	6	6
2231	B:B:H54	B:B:S334	1.39	Yes	No	0	9	4
2232	A:A:D229	A:A:M243	1.39	No	No	0	8	8
2233	A:A:P288	A:A:Y287	1.39	No	Yes	0	6	8
2234	R:R:A125	R:R:R104	1.38	No	Yes	0	4	5
2235	R:R:H724	R:R:V726	1.38	No	No	0	4	3
2236	S:S:N90	S:S:N91	1.36	No	No	0	9	5
2237	R:R:D354	R:R:L353	1.36	No	Yes	0	4	6
2238	B:B:M45	B:B:Q44	1.36	No	No	0	4	4
2239	S:S:D485	S:S:N484	1.35	No	No	0	4	3
2240	R:R:D87	R:R:N91	1.35	No	No	0	7	5
2241	B:B:D267	B:B:N268	1.35	No	No	0	3	4
2242	R:R:R351	R:R:S350	1.32	Yes	No	0	5	4
2243	S:S:H371	S:S:K386	1.31	No	No	0	3	3
2244	S:S:E467	S:S:N466	1.31	No	No	0	4	7
2245	S:S:C755	S:S:W717	1.31	No	Yes	0	4	8
2246	R:R:F593	R:R:V596	1.31	No	No	0	2	3
2247	R:R:F641	R:R:V596	1.31	No	No	0	7	3
2248	A:A:E25	A:A:N22	1.31	No	No	0	4	4
2249	A:A:R205	A:A:V201	1.31	No	No	0	9	9
2250	S:S:D245	S:S:E244	1.3	No	No	0	4	4
2251	S:S:A331	S:S:W308	1.3	No	Yes	0	7	7
2252	R:R:A331	R:R:W308	1.3	No	Yes	0	7	7
2253	R:R:A331	R:R:W314	1.3	No	Yes	0	7	7
2254	R:R:R391	R:R:T389	1.29	No	No	0	3	6
2255	R:R:E227	S:S:E236	1.27	No	No	0	7	5
2256	S:S:E364	S:S:E367	1.27	Yes	No	0	5	6
2257	S:S:E682	S:S:Q683	1.27	No	No	0	6	5
2258	R:R:E401	R:R:E73	1.27	No	Yes	0	5	2
2259	R:R:E401	R:R:Q402	1.27	No	Yes	0	5	6
2260	R:R:E850	R:R:Q851	1.27	No	No	0	6	4
2261	S:S:I772	S:S:R775	1.25	No	No	0	8	9
2262	S:S:K217	S:S:R517	1.24	No	No	0	4	1
2263	R:R:K531	R:R:R554	1.24	No	No	0	6	7
2264	R:R:V533	R:R:W540	1.23	No	No	0	5	8
2265	S:S:N452	S:S:R451	1.21	No	Yes	0	4	6
2266	R:R:I318	R:R:Y480	1.21	No	No	0	4	6
2267	B:B:N295	B:B:R304	1.21	No	No	0	6	5
2268	S:S:K531	S:S:Y555	1.19	No	No	0	6	3
2269	R:R:H541	S:S:H541	1.19	No	No	0	6	6
2270	S:S:D553	S:S:R554	1.19	No	No	0	7	7
2271	S:S:D736	S:S:R733	1.19	No	No	0	3	6
2272	B:B:D254	B:B:R256	1.19	Yes	No	0	9	9
2273	S:S:L709	S:S:Y759	1.17	No	Yes	0	5	8
2274	S:S:D721	S:S:W717	1.12	Yes	Yes	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	S:S:F55	7.2225	4	2	9
2	S:S:H58	5.616	5	3	8
3	S:S:K74	11.456	5	2	5
4	S:S:R78	8.7875	8	2	4
5	S:S:M82	4.855	4	2	8
6	S:S:I99	6.355	4	0	5
7	S:S:L101	5.566	5	0	9
8	S:S:D107	7.4325	4	3	9
9	S:S:C109	5.445	4	3	7
10	S:S:L116	4.8975	4	11	5
11	S:S:F122	5.0975	4	0	5
12	S:S:V151	5.18	4	28	4
13	S:S:S157	4.6525	4	2	5
14	S:S:V161	4.3475	4	0	4
15	S:S:M164	9.77	4	11	5
16	S:S:N167	4.848	5	11	5
17	S:S:I168	4.3975	4	11	5
18	S:S:R170	5.1725	4	0	5
19	S:S:Q176	5.834	5	7	8
20	S:S:Y179	8.0575	4	2	8
21	S:S:D185	5.405	4	7	4
22	S:S:R191	9.876	5	11	5
23	S:S:Y192	10.0275	4	0	5
24	S:S:F195	9.264	5	7	8
25	S:S:R197	7.602	5	7	9
26	S:S:D202	8.725	4	2	8
27	S:S:Y204	4.605	4	0	4
28	S:S:Q205	10.7175	4	2	9
29	S:S:Q207	7.1775	4	16	4
30	S:S:V210	4.425	4	0	6
31	S:S:W218	8.81167	6	0	9
32	S:S:Y220	5.75333	6	30	9
33	S:S:Y230	8.475	6	2	7
34	S:S:I256	4.938	5	21	5
35	S:S:F265	8.692	5	21	4
36	S:S:I269	2.51	4	0	4
37	S:S:L272	4.2725	4	20	8
38	S:S:V281	5.345	4	20	6
39	S:S:F284	6.3525	4	0	8
40	S:S:E287	8.16	4	0	3
41	S:S:D289	5.45	4	21	4
42	S:S:R298	9.46	4	31	3
43	S:S:H305	7.9575	4	0	3
44	S:S:F306	6.09167	6	20	7
45	S:S:W308	4.98	4	20	7
46	S:S:D312	9.925	4	2	8
47	S:S:W314	9.365	4	0	7
48	S:S:H323	11.79	4	31	1
49	S:S:E329	5.0525	4	0	5
50	S:S:P336	7.5275	4	0	5
51	S:S:K337	7.5575	4	0	5
52	S:S:F344	5.3875	4	0	8
53	S:S:R351	10.0075	4	0	5
54	S:S:R358	6.7275	4	0	4
55	S:S:N359	5.9775	4	3	7
56	S:S:W361	7.93	7	3	5
57	S:S:F362	6.69	4	3	5
58	S:S:E364	5.0175	4	3	5
59	S:S:W366	8.616	5	3	6
60	S:S:F370	11.0817	6	3	8
61	S:S:E392	10.7225	4	3	7
62	S:S:I394	5.3375	4	3	5
63	S:S:Q402	6.66	4	0	6
64	S:S:E403	7.155	6	2	5
65	S:S:K405	7.93667	6	2	4
66	S:S:F408	6.7025	4	0	7
67	S:S:M416	4.1925	4	0	6
68	S:S:Y449	5.9025	4	0	4
69	S:S:I450	4.946	5	29	7
70	S:S:R451	4.934	5	0	6
71	S:S:F455	8.96	5	0	9
72	S:S:N461	2.62333	6	0	5
73	S:S:D470	7.245	4	7	7
74	S:S:Y475	8.62	5	0	8
75	S:S:Q479	5.3725	4	0	8
76	S:S:Y489	6.732	5	32	5
77	S:S:W495	6.428	5	16	5
78	S:S:L499	4.754	5	16	7
79	S:S:L501	4.945	4	16	7
80	S:S:Q525	7.4975	4	24	1
81	S:S:E528	8.27	5	24	5
82	S:S:R529	7.9425	4	24	6
83	S:S:Q549	4.795	4	34	7
84	S:S:Y550	7.27	4	35	7
85	S:S:C560	5.185	4	35	9
86	S:S:T567	3.5325	4	36	7
87	S:S:I576	8.3275	4	25	8
88	S:S:I599	3.19	4	0	6
89	S:S:K619	9.54	4	0	7
90	S:S:I633	3.5275	4	0	9
91	S:S:Y637	5.3	5	0	8
92	S:S:F641	4.615	4	0	7
93	S:S:R655	6.35	4	0	8
94	S:S:T672	5.94	4	39	7
95	S:S:Q699	7.43	4	39	8
96	S:S:T703	3.1475	4	0	7
97	S:S:W717	6.34	4	0	8
98	S:S:F718	2.99	4	0	7
99	S:S:D721	6.8825	4	40	6
100	S:S:D731	8.6275	4	25	6
101	S:S:R741	3.84	4	0	5
102	S:S:Y759	6.6725	4	0	8
103	S:S:M761	6.4275	4	0	6
104	S:S:V777	4.9125	4	0	8
105	S:S:E783	6.046	5	38	9
106	S:S:M791	4.6825	4	0	9
107	S:S:T793	5.4725	4	4	8
108	S:S:W798	8.6825	4	4	9
109	S:S:F801	7.2575	4	4	9
110	S:S:V826	3.5275	4	0	8
111	S:S:Y838	7.44833	6	37	9
112	R:R:I49	5.4875	4	0	6
113	R:R:F55	6.372	5	1	9
114	R:R:V57	7.17	4	1	6
115	R:R:H58	6.968	5	1	8
116	R:R:E73	5.11	4	1	2
117	R:R:K74	6.02167	6	1	5
118	R:R:H77	7.995	4	1	6
119	R:R:R78	8.40333	6	1	4
120	R:R:E80	6.15167	6	1	8
121	R:R:L95	5.0175	4	0	7
122	R:R:I99	5.4425	4	0	5
123	R:R:L101	5.2525	4	0	9
124	R:R:R104	4.25	4	0	5
125	R:R:D107	7.8325	4	1	9
126	R:R:C109	6.675	4	1	7
127	R:R:D112	8.7375	4	11	4
128	R:R:L116	5.9425	4	11	5
129	R:R:F122	6.26	4	42	5
130	R:R:S157	7.1425	4	1	5
131	R:R:S159	6.305	4	1	9
132	R:R:V161	3.6425	4	0	4
133	R:R:M164	7.57	4	11	5
134	R:R:L171	5.295	4	0	5
135	R:R:P175	4.42	4	0	8
136	R:R:Q176	7.59	4	0	8
137	R:R:Y179	9.01	4	1	8
138	R:R:T182	5.8025	4	1	8
139	R:R:L186	9.1925	4	43	8
140	R:R:F194	7.054	5	0	7
141	R:R:F195	9.67	5	43	8
142	R:R:P200	7.108	5	1	7
143	R:R:D202	7.496	5	1	8
144	R:R:Q205	7.688	5	1	9
145	R:R:Q207	7.6525	4	1	4
146	R:R:W218	6.61375	8	14	9
147	R:R:Y220	5.772	5	0	9
148	R:R:Y230	8.28125	8	1	7
149	R:R:E264	5.55	5	45	3
150	R:R:F265	6.782	5	17	4
151	R:R:L272	5.675	4	8	8
152	R:R:V281	4.865	4	8	6
153	R:R:F284	6.34167	6	1	8
154	R:R:D289	6.68833	6	17	4
155	R:R:R292	8.3175	4	17	1
156	R:R:L294	7.09	4	8	5
157	R:R:H305	8.495	4	8	3
158	R:R:F306	8.548	5	8	7
159	R:R:F307	6.3825	4	14	7
160	R:R:W308	6.376	5	8	7
161	R:R:D312	6.9675	4	1	8
162	R:R:W314	4.68625	8	1	7
163	R:R:L324	5.3175	4	8	4
164	R:R:E325	4.81	4	0	4
165	R:R:V327	6.928	5	8	3
166	R:R:P336	7.868	5	1	5
167	R:R:F348	7.34	5	1	7
168	R:R:R351	9.166	5	1	5
169	R:R:L353	5.6925	4	0	6
170	R:R:N359	6.745	4	1	7
171	R:R:W361	7.702	5	1	5
172	R:R:F362	8.41	4	1	5
173	R:R:F365	9.76667	6	1	6
174	R:R:N369	9.87	4	1	3
175	R:R:F370	10.748	5	1	8
176	R:R:Q402	4.994	5	26	6
177	R:R:E403	7.8675	4	1	5
178	R:R:K405	7.725	4	1	4
179	R:R:Q407	6.16	4	46	7
180	R:R:F408	6.305	4	0	7
181	R:R:H424	4.595	4	47	5
182	R:R:C428	4.7	5	47	7
183	R:R:Y449	7.3375	4	0	4
184	R:R:F455	6.23	5	0	9
185	R:R:N461	4.0775	4	46	5
186	R:R:N468	6.865	4	44	7
187	R:R:D470	10.6325	4	44	7
188	R:R:Y475	8.515	6	1	8
189	R:R:Q479	8.888	5	14	8
190	R:R:Y489	9.015	4	1	5
191	R:R:W495	6.53	5	1	5
192	R:R:W508	11.0225	4	14	8
193	R:R:P516	7.9575	4	14	8
194	R:R:K530	8.8075	4	0	8
195	R:R:Y550	8.97	5	12	7
196	R:R:C560	8.415	4	12	9
197	R:R:Y562	7.785	4	27	3
198	R:R:M564	8.334	5	12	5
199	R:R:P591	3.895	4	0	8
200	R:R:T615	5.292	5	0	9
201	R:R:I633	5.3225	4	0	9
202	R:R:Y637	6.728	5	0	8
203	R:R:P647	5.0925	4	0	9
204	R:R:S653	3.2975	4	0	5
205	R:R:R655	6.685	4	0	8
206	R:R:F658	4.06	4	0	6
207	R:R:Y667	6.4775	4	0	6
208	R:R:T672	4.8775	4	5	7
209	R:R:R676	7.57286	7	5	8
210	R:R:R679	7.782	5	5	7
211	R:R:I680	4.64	5	5	9
212	R:R:F681	6.41143	7	5	9
213	R:R:Q683	7.975	4	0	5
214	R:R:P691	7.125	4	5	7
215	R:R:I694	4.93	5	5	7
216	R:R:T703	3.855	4	5	7
217	R:R:D721	3.7425	4	50	6
218	R:R:D728	7.8825	4	27	6
219	R:R:Q730	6.99	5	27	3
220	R:R:L753	3.0375	4	0	7
221	R:R:Y759	7.63	4	49	8
222	R:R:V777	6.775	4	5	8
223	R:R:F781	6.658	5	5	9
224	R:R:I787	5.815	4	0	9
225	R:R:Y792	6.35	5	4	9
226	R:R:F801	8.45	7	51	9
227	R:R:F805	12.88	5	0	8
228	R:R:Y838	6.16833	6	22	9
229	R:R:K841	4.8475	4	0	9
230	B:B:L51	7.0375	4	0	9
231	B:B:H54	5.956	5	0	9
232	B:B:Y59	11.2225	4	23	8
233	B:B:I80	6.2675	4	54	8
234	B:B:W82	9.8	4	54	9
235	B:B:N88	6.05	4	0	7
236	B:B:K89	7.77667	6	54	9
237	B:B:H91	7.0775	4	55	5
238	B:B:I93	5.974	5	0	7
239	B:B:W99	9.914	5	6	9
240	B:B:Y105	7.268	5	0	6
241	B:B:I123	4.025	4	0	6
242	B:B:Y124	5.566	5	0	6
243	B:B:L139	9.52	4	0	9
244	B:B:Y145	7.444	5	0	8
245	B:B:F151	4.228	5	0	9
246	B:B:L152	4.2125	4	0	3
247	B:B:T159	6.714	5	15	9
248	B:B:D163	4.8925	4	0	9
249	B:B:W169	12.852	5	15	8
250	B:B:F180	7.434	5	13	7
251	B:B:H183	8.224	5	13	9
252	B:B:K209	9.98	4	13	6
253	B:B:W211	9.132	5	13	8
254	B:B:D212	5.575	4	0	9
255	B:B:F222	4.505	4	9	8
256	B:B:H225	8.35	5	9	9
257	B:B:E226	8.045	4	9	3
258	B:B:F234	3.764	5	0	5
259	B:B:F235	5.872	5	0	6
260	B:B:F241	6.82167	6	9	6
261	B:B:T249	6.8	5	9	6
262	B:B:R251	7.3	6	9	8
263	B:B:F253	7.5675	4	9	6
264	B:B:D254	3.43	4	0	9
265	B:B:F278	7.115	4	0	7
266	B:B:Y289	6.09333	6	0	7
267	B:B:W332	11.7529	7	23	9
268	B:B:D333	9.835	4	18	9
269	B:B:K337	9.688	5	18	6
270	B:B:W339	9.098	5	18	9
271	B:B:N340	10.315	4	0	9
272	A:A:L39	5.94	4	0	9
273	A:A:K46	5.512	5	0	9
274	A:A:H188	12.8375	4	6	3
275	A:A:F189	9.13	4	19	9
276	A:A:Y195	10.3	4	6	4
277	A:A:F196	6.73833	6	0	7
278	A:A:K197	10.946	5	6	7
279	A:A:M198	4.805	4	0	7
280	A:A:F199	9.514	5	6	6
281	A:A:Q204	4.7675	4	6	9
282	A:A:K210	4.68	4	56	9
283	A:A:W211	5.315	4	0	9
284	A:A:F215	8.2125	4	6	9
285	A:A:Y230	8.785	4	0	9
286	A:A:F250	8.69833	6	10	9
287	A:A:W258	6.46	4	23	5
288	A:A:F259	6.5225	4	0	9
289	A:A:I264	5.3375	4	10	6
290	A:A:L266	6.04	4	10	9
291	A:A:F267	6.4	6	59	9
292	A:A:N269	5.685	4	58	9
293	A:A:Y287	8.54857	7	60	8
294	A:A:Y302	9.83	4	60	6
295	A:A:F307	7.466	5	10	8
296	A:A:I319	7.56	4	10	6
297	A:A:Y320	8.75	4	0	8
298	A:A:V332	4.735	4	19	7
299	A:A:F334	11.715	4	0	4
300	A:A:L348	5.5925	4	5	8
301	A:A:C351	3.88	4	0	4
302	A:A:Y354	6.545	4	0	5
303	X:X:?1	8.068	10	4	0
304	M:M:?1	10.6429	7	2	0
305	L:L:?1	8.85375	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	S:S:F408	S:S:K405	13.9057	4.96	Yes	Yes	0	7	4
2	S:S:F408	S:S:Q407	12.7563	8.2	Yes	No	0	7	7
3	S:S:E287	S:S:K74	14.1961	13.5	Yes	Yes	0	3	5
4	R:R:L171	R:R:R170	12.217	4.86	Yes	No	0	5	5
5	S:S:I283	S:S:V224	22.6267	4.61	No	No	0	5	5
6	S:S:I283	S:S:W314	24.7723	5.87	No	Yes	0	5	7
7	S:S:P320	S:S:W314	24.8191	8.11	No	Yes	0	5	7
8	S:S:E287	S:S:P320	24.8492	9.43	Yes	No	0	3	5
9	S:S:V224	S:S:V254	26.1274	4.81	No	No	0	5	5
10	R:R:F408	R:R:K405	12.7768	6.2	Yes	Yes	0	7	4
11	R:R:F408	R:R:V198	15.9076	2.62	Yes	No	0	7	9
12	R:R:F465	R:R:V198	15.8257	2.62	No	No	0	8	9
13	R:R:F455	R:R:H418	15.4531	13.58	Yes	No	0	9	6
14	R:R:H418	R:R:L95	15.3849	6.43	No	Yes	0	6	7
15	R:R:I89	R:R:L95	15.0127	5.71	No	Yes	0	9	7
16	R:R:I89	R:R:L101	14.8915	4.28	No	Yes	0	9	9
17	R:R:I49	R:R:L101	12.7366	5.71	Yes	Yes	0	6	9
18	R:R:I49	R:R:L420	12.5228	5.71	Yes	No	0	6	8
19	R:R:L420	R:R:L446	12.4948	4.15	No	No	0	8	6
20	R:R:L446	R:R:P175	12.4744	6.57	No	Yes	0	6	8
21	R:R:F194	R:R:P175	12.3549	4.33	Yes	Yes	0	7	8
22	R:R:D193	R:R:F194	12.2569	9.55	No	Yes	0	6	7
23	R:R:D193	R:R:R170	12.2434	19.06	No	No	0	6	5
24	R:R:S313	R:R:W314	17.9753	6.18	No	Yes	1	6	7
25	S:S:R271	S:S:V254	25.8939	6.54	No	No	0	3	5
26	R:R:R243	S:S:R271	25.8354	15.99	No	No	0	3	3
27	R:R:A331	R:R:W308	16.0416	1.3	No	Yes	0	7	7
28	R:R:A331	R:R:W314	16.1443	1.3	No	Yes	0	7	7
29	R:R:F284	R:R:V235	25.7834	3.93	Yes	No	0	8	5
30	R:R:T223	R:R:V235	25.7834	4.76	No	No	0	5	5
31	R:R:I250	R:R:T223	25.7957	4.56	No	No	0	6	5
32	R:R:I239	R:R:I250	25.8043	5.89	No	No	0	4	6
33	R:R:I239	R:R:R243	25.8137	3.76	No	No	0	4	3
34	R:R:F284	R:R:Y230	20.8324	4.13	Yes	Yes	1	8	7
35	R:R:S313	R:R:Y230	11.0985	3.82	No	Yes	1	6	7
36	S:S:D731	S:S:G742	10.3839	3.35	Yes	No	0	6	7
37	S:S:G742	S:S:R741	10.5658	3	No	Yes	0	7	5
38	S:S:I579	S:S:R741	12.0163	5.01	No	Yes	0	5	5
39	S:S:I579	S:S:Y816	12.1971	8.46	No	No	0	5	5
40	S:S:V743	S:S:Y816	12.5582	8.83	No	No	0	6	5
41	S:S:L815	S:S:V743	12.7386	7.45	No	No	0	6	6
42	S:S:K745	S:S:L815	12.9189	8.46	No	No	0	7	6
43	S:S:I748	S:S:K745	13.279	2.91	No	No	0	5	7
44	S:S:C746	S:S:I748	16.498	3.27	No	No	0	9	5
45	S:S:C652	S:S:C746	17.562	7.28	No	No	0	9	9
46	S:S:C652	S:S:R655	17.7389	4.18	No	Yes	0	9	8
47	S:S:M643	S:S:R655	20.2025	4.96	No	Yes	0	7	8
48	S:S:M643	S:S:T823	20.5524	4.52	No	No	0	7	7
49	S:S:T640	S:S:T823	20.7272	4.71	No	No	0	7	7
50	S:S:S827	S:S:T640	20.9019	7.99	No	No	0	9	7
51	S:S:S827	S:S:Y637	21.5993	5.09	No	Yes	0	9	8
52	S:S:A830	S:S:Y637	23.5069	4	No	Yes	0	8	8
53	S:S:A830	S:S:I633	23.6796	4.87	No	Yes	0	8	9
54	S:S:I633	S:S:S666	24.1968	3.1	Yes	No	0	9	7
55	S:S:L629	S:S:S666	24.369	3	No	No	0	8	7
56	S:S:L629	S:S:Y838	24.5411	5.86	No	Yes	0	8	9
57	S:S:F609	S:S:Y838	26.535	7.22	No	Yes	0	8	9
58	S:S:F609	S:S:K841	28.2268	4.96	No	No	0	8	9
59	S:S:E783	S:S:K841	29.239	9.45	Yes	No	0	9	9
60	S:S:E783	S:S:P786	30.8086	3.14	Yes	No	0	9	5
61	S:S:K785	S:S:P786	30.9759	5.02	No	No	0	9	5
62	S:S:F789	S:S:K785	31.4769	12.41	No	No	0	9	9
63	R:R:F789	S:S:F789	31.6326	13.93	No	No	4	9	9
64	R:R:F789	S:S:T793	31.9768	3.89	No	Yes	4	9	8
65	R:R:Y792	S:S:T793	42.3595	3.75	Yes	Yes	4	9	8
66	R:R:Y792	S:S:L828	42.8342	5.86	Yes	No	4	9	6
67	S:S:L828	X:X:?1	43.3389	4.13	No	Yes	4	6	0
68	S:S:T790	S:S:T793	11.6505	3.14	No	Yes	0	9	8
69	S:S:M791	S:S:T790	11.4694	3.01	Yes	No	0	9	9
70	S:S:C767	S:S:M791	10.1984	6.48	No	Yes	0	8	9
71	R:R:I802	X:X:?1	50.4661	5.32	No	Yes	0	7	0
72	R:R:F801	R:R:I802	50.3139	3.77	Yes	No	0	9	7
73	R:R:F801	R:R:F805	22.0244	20.36	Yes	Yes	0	9	8
74	R:R:F805	R:R:L753	21.0291	3.65	Yes	Yes	0	8	7
75	R:R:I748	R:R:L753	39.6386	2.85	No	Yes	0	5	7
76	R:R:C746	R:R:I748	39.2979	3.27	No	No	0	9	5
77	R:R:C746	R:R:R655	38.2751	5.57	No	Yes	0	9	8
78	R:R:P647	R:R:R655	31.428	7.21	Yes	Yes	0	9	8
79	R:R:K580	R:R:P647	29.3642	5.02	No	Yes	0	6	9
80	R:R:K580	R:R:L815	28.6752	12.69	No	No	0	6	6
81	R:R:L815	R:R:V743	28.3306	2.98	No	No	0	6	6
82	R:R:F729	R:R:V743	27.9858	22.28	No	No	0	4	6
83	R:R:D731	R:R:F729	27.2958	2.39	No	No	0	6	4
84	R:R:D731	R:R:Y562	26.9507	3.45	No	Yes	0	6	3
85	R:R:R733	R:R:Y562	19.2996	7.2	No	Yes	0	6	3
86	R:R:L735	R:R:R733	16.881	7.29	No	No	0	6	6
87	R:R:L735	R:R:Y548	16.5323	18.76	No	No	0	6	8
88	R:R:F801	R:R:L822	21.1573	8.53	Yes	No	0	9	8
89	R:R:L753	R:R:L822	20.9914	4.15	Yes	No	0	7	8
90	R:R:M764	R:R:Y667	91.4025	3.59	No	Yes	0	8	6
91	R:R:C795	R:R:M764	90.9859	3.24	No	No	52	6	8
92	R:R:C795	R:R:L799	90.9465	3.17	No	No	0	6	6
93	R:R:L799	X:X:?1	90.8322	7.22	No	Yes	0	6	0
94	R:R:C557	R:R:K530	12.3374	1.62	No	Yes	0	9	8
95	R:R:C545	R:R:C557	12.6877	7.28	No	No	0	9	9
96	R:R:C545	R:R:Q549	13.0378	4.58	No	No	0	9	7
97	R:R:Q549	R:R:T546	13.3878	11.34	No	No	0	7	5
98	R:R:G547	R:R:T546	13.7377	1.82	No	No	0	5	5
99	R:R:G547	R:R:Y548	14.0874	1.45	No	No	0	5	8
100	R:R:E783	R:R:K841	10.2019	4.05	No	Yes	0	9	9
101	R:R:E783	R:R:I787	10.5658	6.83	No	Yes	0	9	9
102	R:R:I787	R:R:L670	11.1106	11.42	Yes	No	0	9	7
103	R:R:C767	R:R:L670	11.292	3.17	No	No	0	8	7
104	R:R:C767	R:R:M791	92.7584	4.86	No	No	0	8	9
105	R:R:M791	R:R:Y667	92.4211	5.99	No	Yes	0	9	6
106	R:R:N675	R:R:R679	100	16.87	No	Yes	0	6	7
107	R:R:N675	R:R:Y770	99.896	20.93	No	No	0	6	7
108	R:R:L671	R:R:Y770	99.6877	4.69	No	No	0	8	7
109	R:R:C767	R:R:L671	99.4789	6.35	No	No	0	8	8
110	A:A:L348	A:A:Y354	12.9973	4.69	Yes	Yes	0	8	5
111	A:A:L348	R:R:I680	13.4999	4.28	Yes	Yes	5	8	9
112	R:R:P691	R:R:R679	88.8955	5.76	Yes	Yes	5	7	7
113	R:R:P691	R:R:Q683	90.7289	15.79	Yes	Yes	0	7	5
114	R:R:Q683	R:R:S687	95.6161	7.22	Yes	No	0	5	4
115	A:A:F267	A:A:F334	11.1599	7.5	Yes	Yes	0	9	4
116	A:A:A338	A:A:F334	11.8629	4.16	No	Yes	0	7	4
117	A:A:A338	A:A:Y320	12.097	5.34	No	Yes	0	7	8
118	A:A:K345	A:A:Y354	12.2846	9.55	No	Yes	0	5	5
119	B:B:L210	B:B:L255	14.4625	2.77	No	No	0	5	6
120	B:B:L198	B:B:L210	15.1429	6.92	No	No	0	3	5
121	B:B:D212	B:B:L198	16.1696	2.71	Yes	No	0	9	3
122	B:B:D212	B:B:V213	17.5331	2.92	Yes	No	0	9	4
123	B:B:L152	B:B:V213	17.8736	4.47	Yes	No	0	3	4
124	B:B:L152	B:B:Q156	19.8336	3.99	Yes	No	0	3	5
125	B:B:L168	B:B:Q156	20.1728	3.99	No	No	0	6	5
126	B:B:L168	B:B:T177	20.4853	4.42	No	No	13	6	4
127	B:B:D170	B:B:T177	28.6742	4.34	No	No	0	9	4
128	B:B:D170	B:B:N155	29.6821	5.39	No	No	0	9	3
129	B:B:I171	B:B:N155	30.3533	5.66	No	No	0	6	3
130	B:B:I123	B:B:I171	30.6888	4.42	Yes	No	0	6	6
131	B:B:I123	B:B:L139	34.7402	4.28	Yes	Yes	0	6	9
132	B:B:L139	B:B:W169	35.3978	27.33	Yes	Yes	0	9	8
133	B:B:H142	B:B:W169	34.9608	14.81	No	Yes	15	9	8
134	B:B:H142	B:B:S161	39.198	12.55	No	No	0	9	9
135	B:B:D163	B:B:S161	40.431	4.42	Yes	No	0	9	9
136	B:B:D163	B:B:G144	42.1412	5.03	Yes	No	0	9	8
137	B:B:G144	B:B:N119	42.4834	3.39	No	No	0	8	9
138	A:A:G183	B:B:N119	42.8339	5.09	No	No	0	8	9
139	A:A:G183	A:A:Q204	43.1865	6.58	No	Yes	0	8	9
140	A:A:Q204	B:B:L117	19.7758	3.99	Yes	No	6	9	9
141	B:B:L117	B:B:W99	20.1431	4.56	No	Yes	6	9	9
142	A:A:F199	B:B:W99	37.6945	18.04	Yes	Yes	6	6	9
143	A:A:E186	A:A:F199	32.1768	4.66	No	Yes	6	9	6
144	A:A:E186	A:A:H188	32.1987	16	No	Yes	6	9	3
145	A:A:H188	A:A:Y195	64.5035	23.96	Yes	Yes	6	3	4
146	A:A:K32	A:A:Y195	96.7341	2.39	No	Yes	0	4	4
147	A:A:K32	R:R:S687	95.8284	3.06	No	No	0	4	4
148	A:A:Q204	A:A:W211	23.7894	4.38	Yes	Yes	0	9	9
149	A:A:F215	A:A:W211	26.3532	6.01	Yes	Yes	0	9	9
150	A:A:F199	A:A:F215	58.735	7.5	Yes	Yes	6	6	9
151	A:A:F199	A:A:K197	64.3134	11.17	Yes	Yes	6	6	7
152	A:A:H188	A:A:K197	32.3224	5.24	Yes	Yes	6	3	7
153	A:A:E33	A:A:K197	32.3224	24.3	No	Yes	6	6	7
154	A:A:E33	A:A:Y195	32.3445	12.35	No	Yes	6	6	4
155	B:B:C271	B:B:Y289	12.0224	4.03	No	Yes	0	5	7
156	B:B:C271	B:B:G272	12.4607	3.92	No	No	0	5	4
157	B:B:D246	B:B:G272	12.6796	5.03	No	No	0	9	4
158	B:B:D246	B:B:N230	12.8985	5.39	No	No	0	9	9
159	B:B:N230	B:B:T274	10.978	5.85	No	No	0	9	8
160	B:B:R314	B:B:T274	11.3571	6.47	No	No	0	8	8
161	B:B:R314	B:B:W332	11.7365	28.99	No	Yes	0	8	9
162	B:B:W332	B:B:Y59	19.0314	8.68	Yes	Yes	23	9	8
163	B:B:Q75	B:B:Y59	19.7852	11.27	No	Yes	0	9	8
164	B:B:Q75	B:B:W99	19.97	8.76	No	Yes	0	9	9
165	B:B:D76	B:B:K78	10.011	8.3	No	No	0	9	8
166	A:A:D26	B:B:K78	13.3618	4.15	No	No	0	5	8
167	A:A:D26	A:A:K29	13.4684	4.15	No	No	0	5	2
168	A:A:K29	A:A:K32	13.5798	2.87	No	No	0	2	4
169	B:B:F234	B:B:L255	11.7247	2.44	Yes	No	0	5	6
170	A:A:F215	A:A:L37	42.0799	7.31	Yes	No	0	9	9
171	A:A:L37	A:A:L39	26.4001	5.54	No	Yes	0	9	9
172	A:A:I221	A:A:L37	15.6359	8.56	No	No	0	7	9
173	A:A:F223	A:A:L39	23.9649	10.96	No	Yes	0	9	9
174	A:A:I221	A:A:I264	17.052	5.89	No	Yes	0	7	6
175	A:A:F223	A:A:F250	11.929	18.22	No	Yes	10	9	9
176	A:A:F250	A:A:I264	13.2548	3.77	Yes	Yes	10	9	6
177	A:A:F223	A:A:L266	11.868	3.65	No	Yes	10	9	9
178	A:A:F250	A:A:F307	23.9656	11.79	Yes	Yes	10	9	8
179	A:A:F307	A:A:L266	11.3456	4.87	Yes	Yes	10	8	9
180	A:A:M247	A:A:Y287	33.1193	7.18	No	Yes	0	6	8
181	A:A:F307	A:A:M247	33.6675	6.22	Yes	No	0	8	6
182	A:A:Y287	A:A:Y302	10.5102	9.93	Yes	Yes	60	8	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:K71	S:S:K74	10.06	0	No	Yes	5	5	2	1
S:S:K74	S:S:R78	14.85	2	Yes	Yes	5	4	1	1
S:S:E287	S:S:K74	13.5	0	Yes	Yes	3	5	2	1
S:S:E403	S:S:K74	8.1	2	Yes	Yes	5	5	2	1
M:M:?1	S:S:K74	10.77	2	Yes	Yes	0	5	0	1
S:S:R78	S:S:S157	3.95	2	Yes	Yes	4	5	1	2
S:S:R78	S:S:Y179	9.26	2	Yes	Yes	4	8	1	2
S:S:A180	S:S:R78	4.15	2	No	Yes	6	4	1	1
S:S:E403	S:S:R78	13.96	2	Yes	Yes	5	4	2	1
S:S:K405	S:S:R78	9.9	2	Yes	Yes	4	4	1	1
S:S:R78	S:S:V409	3.92	2	Yes	No	4	7	1	2
M:M:?1	S:S:R78	10.31	2	Yes	Yes	0	4	0	1
S:S:S157	S:S:Y179	3.82	2	Yes	Yes	5	8	2	2
S:S:S159	S:S:S181	4.89	2	No	No	9	8	1	2
S:S:S159	S:S:Y230	5.09	2	No	Yes	9	7	1	1
M:M:?1	S:S:S159	3.82	2	Yes	No	0	9	0	1
S:S:V409	S:S:Y179	8.83	2	No	Yes	7	8	2	2
S:S:A180	S:S:K405	6.42	2	No	Yes	6	4	1	1
M:M:?1	S:S:A180	5.35	2	Yes	No	0	6	0	1
S:S:D202	S:S:Y230	6.9	2	Yes	Yes	8	7	2	1
S:S:G231	S:S:Y230	4.35	0	No	Yes	8	7	2	1
S:S:S311	S:S:Y230	3.82	0	No	Yes	8	7	2	1
S:S:S313	S:S:Y230	3.82	2	No	Yes	6	7	1	1
M:M:?1	S:S:Y230	26.87	2	Yes	Yes	0	7	0	1
S:S:E287	S:S:S313	4.31	0	Yes	No	3	6	2	1
S:S:D312	S:S:K405	11.06	2	Yes	Yes	8	4	2	1
M:M:?1	S:S:S313	10.2	2	Yes	No	0	6	0	1
S:S:E403	S:S:K405	8.1	2	Yes	Yes	5	4	2	1
S:S:F408	S:S:K405	4.96	0	Yes	Yes	7	4	2	1
M:M:?1	S:S:K405	7.18	2	Yes	Yes	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
100.00	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
100.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
100.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
100.00	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
100.00	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
100.00	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
100.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
100.00	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
100.00	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
100.00	Single	7DD5	Ca3	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
100.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
100.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
100.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
100.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
100.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00	Single	7EB2	Baclofen	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
100.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
100.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
100.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
100.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
100.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
100.00	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00	Single	7FII	hCG	7FII-LH-hCG-6fuf
100.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
100.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
100.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
100.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
100.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
100.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
100.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
100.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
100.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
100.00	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
100.00	Single	7XW7	K1-70	7XW7-TSH-K1-70
100.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
100.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
100.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
100.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
100.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
100.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
100.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
100.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
100.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
100.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
100.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
100.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
100.00	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-J9R
100.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
100.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
100.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
100.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
100.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
100.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
100.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
100.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
100.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
100.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
100.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
100.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
100.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
100.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
100.00	Consensus	fsh_on_allo	Orthosteric Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
100.00	Consensus	gabab_off	Orthosteric Ligand	7C7S-GABA_B1, GABA_B2-CGP54626 7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid 6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
100.00	Consensus	gabab_on	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
100.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
100.00	Consensus	gi_gaba	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	gphr_on	Orthosteric Ligand	lh_on tsh_on
100.00	Consensus	gs_gphr	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00	Consensus	gs_protein	Orthosteric Ligand	gs_gphr
100.00	Consensus	lh_on	Orthosteric Ligand	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00	Consensus	lh_on_allo	Orthosteric Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
100.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
100.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
100.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
100.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
100.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
100.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
100.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
100.00	Consensus	smo_off_allo	Other Ligand	6D32-SMO-Cyclopamine-Cyclopamine
100.00	Consensus	tsh_on	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2
100.00	Consensus	tsh_on_allo	Orthosteric Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
50.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
33.33	Single	8HS2	Fab046	8HS2-GPR20-Fab046
25.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
25.00	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00	Single	7UTZ	TR1402	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
25.00	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
25.00	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
20.00	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
20.00	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/&β;1/&γ;2
20.00	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
20.00	Single	8I2G	Glycoprotein hormones alpha chain	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
14.29	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
14.29	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
14.29	Single	6LI0	GTPL9804	6LI0-GPR52-GTPL9804
14.29	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
14.29	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
14.29	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
12.50	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
12.50	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
12.50	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
12.50	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50	Consensus	go_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.50	Consensus	go_protein	Orthosteric Ligand	go_chemokine
12.50	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
11.11	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
11.11	Single	5U09	Taranabant	5U09-CB₁-Taranabant
11.11	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.11	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
11.11	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
11.11	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
11.11	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
11.11	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
11.11	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
11.11	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
11.11	Single	8HMP	PubChem 69921479	8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Consensus	class-f_off	Orthosteric Ligand	smo_off
11.11	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
11.11	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
11.11	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
10.00	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
10.00	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
10.00	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.00	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
10.00	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
10.00	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
10.00	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
10.00	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
10.00	Consensus	gi_class-f	Orthosteric Ligand	gi_frizzled
10.00	Consensus	gi_frizzled	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
10.00	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
10.00	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
9.09	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
9.09	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
9.09	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
9.09	Single	6D27	CAY10471	6D27-DP₂-CAY10471
9.09	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.09	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
9.09	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
9.09	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
9.09	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
9.09	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
9.09	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
9.09	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
9.09	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
9.09	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.09	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
9.09	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
9.09	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.33	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
8.33	Single	5C1M	BU72	5C1M-μ-BU72
8.33	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.33	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.33	Single	7C4S	S1P	7C4S-S1P₃-S1P
8.33	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
8.33	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
8.33	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.33	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
8.33	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
8.33	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
8.33	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.69	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
7.69	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
7.69	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
7.69	Single	5V56	TC114	5V56-SMO-TC114
7.69	Single	5V57	TC114	5V57-SMO-TC114
7.69	Single	6OS1	TRV026	6OS1-AT₁-TRV026
7.69	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
7.69	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.69	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
7.69	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
7.69	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.69	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.69	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.69	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
7.69	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
7.69	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
7.69	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Single	8E0G	BU72	8E0G-μ-BU72
7.69	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
7.69	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
7.69	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.69	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
7.69	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
7.69	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
7.69	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.69	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
7.14	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
7.14	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
7.14	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
7.14	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
7.14	Single	6OS2	TRV026	6OS2-AT₁-TRV026
7.14	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.14	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
7.14	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
7.14	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.14	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
7.14	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
7.14	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.14	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
7.14	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
7.14	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
7.14	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
7.14	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
7.14	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
7.14	Consensus	dp_off	Orthosteric Ligand	dp2_off
7.14	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
7.14	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
7.14	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.14	Consensus	nts_on	Orthosteric Ligand	nts1_on
7.14	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
7.14	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.67	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
6.67	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
6.67	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
6.67	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
6.67	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
6.67	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
6.67	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6.67	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
6.67	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
6.67	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
6.67	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.67	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.67	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
6.25	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
6.25	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
6.25	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
6.25	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
6.25	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
6.25	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
6.25	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
6.25	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
6.25	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
6.25	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
6.25	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
6.25	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
5.88	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
5.88	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.88	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.88	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
5.88	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
5.88	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
5.88	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.88	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
5.88	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.88	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.88	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.88	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
5.88	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.88	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.88	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.88	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
5.88	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
5.56	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
5.56	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.56	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
5.56	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
5.56	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
5.56	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
5.56	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
5.56	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.56	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
5.56	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.56	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.56	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
5.56	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
5.26	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
5.26	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
5.26	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
5.26	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
5.26	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
5.26	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.26	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
5.26	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
5.26	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.26	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
5.26	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
5.26	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
5.26	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
5.26	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
5.00	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
5.00	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
5.00	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
5.00	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
5.00	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.00	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
5.00	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
5.00	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
5.00	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
5.00	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
5.00	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
5.00	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
5.00	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
5.00	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.00	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
5.00	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
5.00	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.76	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.76	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
4.76	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.76	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.76	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.76	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.76	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.76	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.76	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.76	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.76	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
4.76	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
4.76	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.76	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
4.76	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
4.55	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
4.55	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
4.55	Single	6FJ3	PTH	6FJ3-PTH1-PTH
4.55	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.55	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.55	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
4.55	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
4.55	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
4.55	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.55	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
4.55	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
4.55	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.55	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.55	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
4.55	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.55	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.35	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
4.35	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
4.35	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
4.35	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.35	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
4.35	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
4.35	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
4.35	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.35	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.35	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.35	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
4.35	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.35	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
4.35	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
4.35	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.35	Consensus	go_class-b1	Orthosteric Ligand	go_crf
4.35	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.35	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.17	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
4.17	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
4.17	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.17	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
4.17	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.17	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
4.17	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.17	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
4.17	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
4.17	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
4.17	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
4.17	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
4.17	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
4.17	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.17	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.17	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.17	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
4.17	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
4.17	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
4.17	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.00	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
4.00	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.00	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
4.00	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
4.00	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.00	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
4.00	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.00	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
4.00	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
4.00	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.00	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
4.00	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.00	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
3.85	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.85	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
3.85	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.85	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.85	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.85	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.85	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
3.85	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
3.70	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
3.70	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.70	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.70	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.70	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.70	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
3.57	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.57	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.57	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.57	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.57	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.57	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.57	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.57	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.57	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
3.57	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.45	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.45	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.45	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
3.45	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
3.33	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.33	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.23	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.23	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
3.23	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.12	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
3.12	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
3.12	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.03	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
3.03	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
3.03	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.94	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.94	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.86	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:L590	S:S:P591	4.93	0	No	No	4	8	1	2
S:S:L590	X:X:?1	8.25	0	No	Yes	4	0	1	0
S:S:P591	S:S:V824	5.3	0	No	No	8	7	2	1
S:S:F801	S:S:W798	10.02	4	Yes	Yes	9	9	2	2
S:S:S825	S:S:W798	4.94	4	No	Yes	8	9	1	2
S:S:F801	S:S:S825	7.93	4	Yes	No	9	8	2	1
S:S:I804	S:S:T821	9.12	4	No	No	7	8	1	1
S:S:I804	X:X:?1	5.32	4	No	Yes	7	0	1	0
S:S:T821	X:X:?1	4.4	4	No	Yes	8	0	1	0
S:S:V824	X:X:?1	18.88	0	No	Yes	7	0	1	0
S:S:S825	X:X:?1	6.72	4	No	Yes	8	0	1	0
R:R:Y792	S:S:L828	5.86	4	Yes	No	9	6	2	1
R:R:I796	S:S:L828	4.28	4	No	No	8	6	2	1
S:S:L828	X:X:?1	4.13	4	No	Yes	6	0	1	0
R:R:I796	R:R:Y792	13.3	4	No	Yes	8	9	2	2
R:R:L799	X:X:?1	7.22	0	No	Yes	6	0	1	0
R:R:F801	R:R:I802	3.77	51	Yes	No	9	7	2	1
R:R:I802	X:X:?1	5.32	0	No	Yes	7	0	1	0
R:R:P803	X:X:?1	17.14	0	No	Yes	9	0	1	0
S:S:T820	X:X:?1	3.3	0	No	Yes	8	0	1	0
R:R:A800	S:S:I804	3.25	0	No	No	7	7	2	1
R:R:C795	R:R:L799	3.17	52	No	No	6	6	2	1
S:S:I817	S:S:T820	3.04	0	No	No	5	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
53.33	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
22.22	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
20.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
15.38	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.38	Consensus	class-d_on	Orthosteric Ligand	ste2_on
15.38	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
15.38	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.79	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
13.33	Single	7F61	Cholesterol	7F61-H₃-PF-03654746-Cholesterol
13.33	Consensus	adgrg3_on	Orthosteric Ligand	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
13.33	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
13.33	Consensus	gip_on_allo	Other Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
13.33	Consensus	h3_on_allo	Other Ligand	7F61-H₃-PF-03654746-Cholesterol
13.04	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
12.90	Consensus	gs_crf	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
12.50	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
12.50	Single	7XKF	Betahydroxyandrosterone	7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
12.50	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
12.50	Consensus	go_adhesion	Orthosteric Ligand	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
12.50	Consensus	go_class-b2	Orthosteric Ligand	go_adhesion
12.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
11.54	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
11.11	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
11.11	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
11.11	Single	6WJC	Atropine	6WJC-M₁-Atropine-Muscarinic toxin 7
11.11	Single	7ZBE	11-cis-Retinal	7ZBE-Rhodopsin-11-cis-Retinal
11.11	Single	8GGL	Epinephrine	8GGL-β₂-Epinephrine
11.11	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
11.11	Consensus	5ht2a_on	Orthosteric Ligand	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11	Consensus	ghrelin_off	Orthosteric Ligand	6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
11.11	Consensus	m1_off_allo	Orthosteric Ligand	6WJC-M₁-Atropine-Muscarinic toxin 7
10.71	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
10.71	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
10.71	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
10.53	Single	4DAJ	Tiotropium	4DAJ-M₃-Tiotropium
10.53	Single	4MQS	Iperoxo	4MQS-M₂-Iperoxo
10.53	Single	4U14	Tiotropium	4U14-M₃-Tiotropium
10.53	Single	4U16	N-Methyl Scopolamine	4U16-M₃-N-Methyl Scopolamine
10.53	Single	5DSG	Tiotropium	5DSG-M₄-Tiotropium
10.53	Single	5YC8	N-Methyl Scopolamine	5YC8-M₂-N-Methyl Scopolamine
10.53	Single	5ZK8	N-Methyl Scopolamine	5ZK8-M₂-N-Methyl Scopolamine
10.53	Single	5ZKC	N-Methyl Scopolamine	5ZKC-M₂-N-Methyl Scopolamine
10.53	Single	6WHA	DB13948	6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
10.53	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
10.53	Single	7TRP	Iperoxo	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
10.53	Single	8J18	(3R)-3-hydroxydodecanoic acid	8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
10.53	Consensus	cck_off	Orthosteric Ligand	ccka_off
10.53	Consensus	ccka_off	Orthosteric Ligand	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
10.53	Consensus	go_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
10.53	Consensus	histamine_on	Orthosteric Ligand	h1_on h4_on
10.53	Consensus	m4_off	Orthosteric Ligand	5DSG-M₄-Tiotropium
10.53	Consensus	m4_on_allo	Orthosteric Ligand	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
10.53	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
10.34	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
10.34	Consensus	class-d_on	Orthosteric Ligand	ste2_on
10.00	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
10.00	Single	5ZK3	Quinuclidinyl benzilate hydrobromide	5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
10.00	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
10.00	Single	6OIK	Iperoxo	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
10.00	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
10.00	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.00	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
10.00	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
10.00	Single	7TRK	Iperoxo	7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2
10.00	Single	8E9Z	Iperoxo	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00	Single	8EA0	Iperoxo	8EA0-M₃-Iperoxo
10.00	Single	8EFB	Oliceridine	8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
10.00	Single	8J19	PubChem 127045422	8J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
10.00	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
10.00	Consensus	a2a_on	Orthosteric Ligand	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
10.00	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
10.00	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.00	Consensus	go_class-b1	Orthosteric Ligand	go_crf
10.00	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
10.00	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.00	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
10.00	Consensus	gs_muscarinic	Orthosteric Ligand	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00	Consensus	m2_off	Orthosteric Ligand	5ZKB-M₂-AF-DX 384 5ZKC-M₂-N-Methyl Scopolamine 5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
10.00	Consensus	m3_on	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.68	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
9.68	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
9.68	Consensus	crf1_on	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
9.52	Single	2YDV	NECA	2YDV-A_2A-NECA
9.52	Single	3UON	Quinuclidinyl benzilate hydrobromide	3UON-M₂-Quinuclidinyl benzilate hydrobromide
9.52	Single	4U15	Tiotropium	4U15-M₃-Tiotropium
9.52	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
9.52	Single	5G53	NECA	5G53-A_2A-NECA-Gs
9.52	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
9.52	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
9.52	Single	5ZKB	AF-DX 384	5ZKB-M₂-AF-DX 384
9.52	Single	6OL9	Tiotropium	6OL9-M₅-Tiotropium
9.52	Single	7EPE	NAM563	7EPE-mGlu-NAM563
9.52	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
9.52	Single	7TRQ	Iperoxo	7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
9.52	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
9.52	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.52	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
9.52	Consensus	m3_off	Orthosteric Ligand	4U15-M₃-Tiotropium 4U16-M₃-N-Methyl Scopolamine 5ZHP-M₃-PubChem 134828589
9.52	Consensus	m5_off	Orthosteric Ligand	6OL9-M₅-Tiotropium
9.52	Consensus	muscarinic_off	Orthosteric Ligand	m2_off m3_off m4_off m5_off m1_off
9.52	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
9.52	Consensus	npy_off	Orthosteric Ligand	npy2_off npy1_off
9.38	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
9.38	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
9.09	Single	5CXV	Tiotropium	5CXV-M₁-Tiotropium
9.09	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
9.09	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
9.09	Single	8W8R	AA-14	8W8R-GPR101-AA-14-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg3_on
9.09	Consensus	class-b2_on	Orthosteric Ligand	adgrg_on
9.09	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
9.09	Consensus	m1_off	Orthosteric Ligand	5CXV-M₁-Tiotropium
8.82	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
8.70	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
8.70	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
8.70	Single	8E9Y	PubChem 446603	8E9Y-M₃-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
8.70	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
8.70	Consensus	adgrg2_on	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
8.33	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
8.33	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
8.33	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
8.33	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
8.33	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
8.33	Consensus	gs_adgr	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
8.33	Consensus	gs_class-b2	Orthosteric Ligand	gs_adgr
8.00	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
7.69	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
7.69	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
7.69	Single	8WCB	Cyclohexylammonium ion	8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
7.41	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
7.41	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
7.41	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
7.14	Single	7XKE	Betahydroxyandrosterone	7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
7.14	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
6.90	Single	7KH0	Acyclovir triphosphate	7KH0-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
6.90	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
6.90	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
6.67	Single	6FJ3	PTH	6FJ3-PTH1-PTH
6.67	Single	6OY9	All-trans-retinal	6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
6.67	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
6.67	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
6.67	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
6.67	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Single	7XKD	Betahydroxyandrosterone	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.67	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
6.67	Consensus	ghrh_on	Orthosteric Ligand	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
6.67	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
6.45	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
6.45	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
6.45	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
6.25	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
6.25	Single	3UZA	GTPL9236	3UZA-A_2A-GTPL9236
6.25	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
6.25	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
6.25	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
6.25	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
6.25	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
6.25	Single	8DPI	Lorcaserin	8DPI-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25	Single	8FEG	PRD_002517	8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
6.25	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
6.25	Single	8IW7	2-Phenylethylamine	8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	8JXT	Histamine	8JXT-H₄-Histamine-PO4-Gi1/&β;1/&γ;2
6.25	Single	8POK	Histamine	8POK-H₂-Histamine-Gs/&β;1/&γ;2
6.25	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	8WC9	ZH8651	8WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
6.25	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
6.25	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
6.06	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Single	1U19	11-cis-Retinal	1U19-Rhodopsin-11-cis-Retinal
5.88	Single	2G87	All-trans-retinal	2G87-Rhodopsin-All-trans-retinal
5.88	Single	2I35	11-cis-Retinal	2I35-Rhodopsin-11-cis-Retinal
5.88	Single	3AYM	All-trans-retinal	3AYM-Rhodopsin-All-trans-retinal
5.88	Single	3PBL	Eticlopride	3PBL-D₃-Eticlopride
5.88	Single	5OLV	LUAA41063	5OLV-A_2A-LUAA41063-Na
5.88	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
5.88	Single	6TP4	ACT-462206	6TP4-OX₁-ACT-462206
5.88	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.88	Single	7DFL	Histamine	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
5.88	Single	7E2Y	Serotonin	7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2
5.88	Single	7LD3	PubChem 25263603	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
5.88	Single	7UL2	SR48692	7UL2-NTS₁-SR48692-Na
5.88	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/&β;1/&γ;2
5.88	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2
5.88	Single	7XTB	Serotonin	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2
5.88	Single	7YFC	Histamine	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Single	7YFD	Imetit	7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Single	7YS6	Serotonin	7YS6-5-HT₆-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Single	8A2P	LUAA47070	8A2P-A_2A-LUAA47070-Na
5.88	Single	8DPF	Lorcaserin	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88	Single	8EF6	Morphine	8EF6-μ-Morphine-Gi1/&β;1/&γ;2
5.88	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
5.88	Single	8GGS	Epinephrine	8GGS-β₂-Epinephrine
5.88	Single	8GGY	Epinephrine	8GGY-β₂-Epinephrine
5.88	Single	8HN8	Histamine	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2
5.88	Single	8ITF	DMCHA	8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
5.88	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.88	Single	8UNV	Epinephrine	8UNV-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.88	Single	8UNX	Epinephrine	8UNX-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.88	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
5.88	Single	8W8B	SEP-363856	8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2
5.88	Single	8WC3	SEP-363856	8WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Consensus	5ht4_on	Orthosteric Ligand	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
5.88	Consensus	a1_on_allo	Other Ligand	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
5.88	Consensus	d3_off	Orthosteric Ligand	3PBL-D₃-Eticlopride
5.88	Consensus	gq_histamine	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
5.88	Consensus	h1_on	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
5.88	Consensus	nts1_off_allo	Orthosteric Ligand	7UL2-NTS₁-SR48692-Na
5.88	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.71	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
5.71	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
5.56	Single	2PED	9-cis-Retinal	2PED-Rhodopsin-9-cis-Retinal
5.56	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
5.56	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
5.56	Single	3VG9	ZM241385	3VG9-A_2A-ZM241385-Antibody
5.56	Single	3VGA	ZM241385	3VGA-A_2A-ZM241385-Antibody
5.56	Single	4S0V	Suvorexant	4S0V-OX₂-Suvorexant
5.56	Single	5DHH	SB-612111	5DHH-NOP-SB-612111
5.56	Single	5K2D	ZM241385	5K2D-A_2A-ZM241385
5.56	Single	5OLH	Vipadenant	5OLH-A_2A-Vipadenant-Na
5.56	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
5.56	Single	5U09	Taranabant	5U09-CB₁-Taranabant
5.56	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/&β;1/&γ;2
5.56	Single	6JZH	ZM241385	6JZH-A_2A-ZM241385-Na
5.56	Single	6KUX	RS-79948	6KUX-α_2a-RS-79948
5.56	Single	6KUY	PubChem 145704643	6KUY-α_2a-PubChem 145704643
5.56	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
5.56	Single	6NWE	Octyl Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
5.56	Single	6OBA	(S)-Alprenolol	6OBA-β₂-(S)-Alprenolol-GTPL11074
5.56	Single	6PS7	ZM241385	6PS7-A_2A-ZM241385-Na
5.56	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
5.56	Single	6TPJ	Suvorexant	6TPJ-OX₂-Suvorexant
5.56	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
5.56	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56	Single	7DHR	Isoprenaline	7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2
5.56	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
5.56	Single	7F24	Dopamine	7F24-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
5.56	Single	7F8U	Lintitript	7F8U-CCK_A-Lintitript
5.56	Single	7F8Y	Devazepide	7F8Y-CCK_A-Devazepide
5.56	Single	7LJD	Dopamine	7LJD-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;1
5.56	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
5.56	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
5.56	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.56	Single	7SRS	LSD	7SRS-5-HT_2B-LSD-Arrestin2
5.56	Single	7T6S	PubChem 24776341	7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
5.56	Single	7T8X	Acetylcholine	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
5.56	Single	7T90	Acetylcholine	7T90-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
5.56	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
5.56	Single	7X2F	Dopamine	7X2F-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
5.56	Single	7X5H	5-CT	7X5H-5-HT_5A-5-CT-Gi1/&β;1/&γ;2
5.56	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
5.56	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
5.56	Single	7YM8	Oxymetazoline	7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
5.56	Single	7YMH	Norepinephrine	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
5.56	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
5.56	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
5.56	Single	8GEA	Epinephrine	8GEA-β₂-Epinephrine-Gs/&β;1/&γ;2
5.56	Single	8GEC	Epinephrine	8GEC-β₂-Epinephrine-Gs/&β;1/&γ;2
5.56	Single	8GED	Epinephrine	8GED-β₂-Epinephrine-Gs/&β;1/&γ;2
5.56	Single	8GEF	Epinephrine	8GEF-β₂-Epinephrine-Gs/&β;1/&γ;2
5.56	Single	8GG7	Epinephrine	8GG7-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56	Single	8GG9	Epinephrine	8GG9-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56	Single	8GGA	Epinephrine	8GGA-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56	Single	8GGV	Epinephrine	8GGV-β₂-Epinephrine
5.56	Single	8GGX	Epinephrine	8GGX-β₂-Epinephrine
5.56	Single	8GH0	Epinephrine	8GH0-β₂-Epinephrine
5.56	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2
5.56	Single	8HOC	Imetit	8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
5.56	Single	8IW4	Spermidine	8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Single	8IWE	Spermidine	8IWE-TAAR9-Spermidine
5.56	Single	8UNL	Epinephrine	8UNL-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56	Single	8UNO	Epinephrine	8UNO-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56	Single	8UNT	Epinephrine	8UNT-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56	Single	8UNU	Epinephrine	8UNU-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56	Single	8UNW	Epinephrine	8UNW-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56	Single	8UO1	Epinephrine	8UO1-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
5.56	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.56	Consensus	5ht2_on	Orthosteric Ligand	5ht2a_on 5ht2c_on
5.56	Consensus	5ht2c_on	Orthosteric Ligand	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56	Consensus	5ht_on	Orthosteric Ligand	5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
5.56	Consensus	a2a_off_allo	Orthosteric Ligand	6ZDR-A_2A-HMS1413f12-Na 6GT3-A_2A-Imaradenant-Na 8CU7-A_2A-LJ-4517-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PubChem 92460631; psb36-Na 5MZJ-A_2A-Theophylline-Na 5OLO-A_2A-Tozadenant-Na 5OLH-A_2A-Vipadenant-Na 5NM4-A_2A-ZM241385-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5MZP-A_2A-Caffeine-Na 8CIC-A_2A-Etrumadenant-Na
5.56	Consensus	alpha1_on	Orthosteric Ligand	alpha1a_on
5.56	Consensus	alpha1a_on	Orthosteric Ligand	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56	Consensus	alpha2_off	Orthosteric Ligand	alpha2a_off alpha2c_off
5.56	Consensus	alpha2a_off	Orthosteric Ligand	6KUX-α_2a-RS-79948
5.56	Consensus	beta2_off_allo	Orthosteric Ligand	6OBA-β₂-(S)-Alprenolol-GTPL11074
5.56	Consensus	gi_histamine	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2 8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
5.56	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
5.56	Consensus	gs_5ht	Orthosteric Ligand	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56	Consensus	gs_histamine	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
5.56	Consensus	h4_on	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Consensus	m2_on	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
5.56	Consensus	opsin_off	Orthosteric Ligand	1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
5.56	Consensus	smo_on_allo	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.41	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
5.41	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
5.26	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
5.26	Single	3REY	PubChem 5697	3REY-A_2A-PubChem 5697
5.26	Single	3RZE	Cidoxepin	3RZE-H₁-Cidoxepin
5.26	Single	3UZC	PubChem 135566609	3UZC-A_2A-PubChem 135566609
5.26	Single	4LDO	L-Epinephrine	4LDO-β₂-L-Epinephrine
5.26	Single	4MQT	Iperoxo	4MQT-M₂-Iperoxo-LY2119620
5.26	Single	5IU4	ZM241385	5IU4-A_2A-ZM241385-Na
5.26	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
5.26	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
5.26	Single	5JTB	ZM241385	5JTB-A_2A-ZM241385
5.26	Single	5K2B	ZM241385	5K2B-A_2A-ZM241385-Na
5.26	Single	5K2C	ZM241385	5K2C-A_2A-ZM241385-Na
5.26	Single	5NLX	ZM241385	5NLX-A_2A-ZM241385-Na
5.26	Single	5NM4	ZM241385	5NM4-A_2A-ZM241385-Na
5.26	Single	5TE3	Octyl Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
5.26	Single	5UVI	ZM241385	5UVI-A_2A-ZM241385
5.26	Single	6A94	Zotepine	6A94-5-HT_2A-Zotepine
5.26	Single	6AQF	ZM241385	6AQF-A_2A-ZM241385
5.26	Single	6FFI	MMPEP	6FFI-mGlu₅-MMPEP
5.26	Single	6IQL	L745870	6IQL-D₄-L745870
5.26	Single	6K41	Dexmedetomidine	6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2
5.26	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
5.26	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
5.26	Single	6PS4	ICI 118-551	6PS4-β₂-ICI 118-551
5.26	Single	6PS5	(S)-Propranolol	6PS5-β₂-(S)-Propranolol
5.26	Single	6TOS	GSK1059865	6TOS-OX₁-GSK1059865-Na
5.26	Single	6TP3	Nemorexant	6TP3-OX₁-Nemorexant
5.26	Single	6TPG	EMPA	6TPG-OX₂-EMPA
5.26	Single	6TPN	HTL6641	6TPN-OX₂-HTL6641
5.26	Single	6WH4	Methiothepin	6WH4-5-HT_2A-Methiothepin
5.26	Single	6ZA8	RTI-3a	6ZA8-NTS₁-RTI-3a
5.26	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
5.26	Single	6ZDV	PubChem 984073	6ZDV-A_2A-PubChem 984073-Na
5.26	Single	6ZIN	SR48692	6ZIN-NTS₁-SR48692
5.26	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/&β;1/&γ;2
5.26	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
5.26	Single	7CMU	Pramipexole	7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
5.26	Single	7CMV	PD128907	7CMV-D₃-PD128907-Gi1/&β;1/&γ;2
5.26	Single	7DHI	Salbutamol	7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2
5.26	Single	7E33	BRL-54443	7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2
5.26	Single	7EJ8	Brimonidine	7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2
5.26	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2
5.26	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/&β;1/&γ;2
5.26	Single	7RAN	PubChem 164575847	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26	Single	7T32	ZM241385	7T32-A_2A-ZM241385
5.26	Single	7T94	Acetylcholine	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
5.26	Single	7TRS	Acetylcholine	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2
5.26	Single	7UM7	Methylergometrine	7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
5.26	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
5.26	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
5.26	Single	7VVO	PTH	7VVO-PTH1-PTH-Gs/&β;1/&γ;2
5.26	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
5.26	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
5.26	Single	8FCZ	11-cis-Retinal	8FCZ-Rhodopsin-11-cis-Retinal
5.26	Single	8GCM	L902688	8GCM-EP₄-L902688-Gi1/&β;1/&γ;2
5.26	Single	8GDZ	Epinephrine	8GDZ-β₂-Epinephrine-Gs/&β;1/&γ;2
5.26	Single	8GE1	Epinephrine	8GE1-β₂-Epinephrine-Gs/&β;1/&γ;2
5.26	Single	8GE4	Epinephrine	8GE4-β₂-Epinephrine-Gs/&β;1/&γ;2
5.26	Single	8GE6	Epinephrine	8GE6-β₂-Epinephrine-Gs/&β;1/&γ;2
5.26	Single	8GE7	Epinephrine	8GE7-β₂-Epinephrine-Gs/&β;1/&γ;2
5.26	Single	8GE8	Epinephrine	8GE8-β₂-Epinephrine-Gs/&β;1/&γ;2
5.26	Single	8GE9	Epinephrine	8GE9-β₂-Epinephrine-Gs/&β;1/&γ;2
5.26	Single	8GEG	Epinephrine	8GEG-β₂-Epinephrine-Gs/&β;1/&γ;2
5.26	Single	8GFV	Epinephrine	8GFV-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26	Single	8GG3	Epinephrine	8GG3-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26	Single	8GG4	Epinephrine	8GG4-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26	Single	8GG5	Epinephrine	8GG5-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26	Single	8GG8	Epinephrine	8GG8-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26	Single	8GGI	Epinephrine	8GGI-β₂-Epinephrine
5.26	Single	8GGK	Epinephrine	8GGK-β₂-Epinephrine
5.26	Single	8GGM	Epinephrine	8GGM-β₂-Epinephrine
5.26	Single	8GGP	Epinephrine	8GGP-β₂-Epinephrine
5.26	Single	8GGQ	Epinephrine	8GGQ-β₂-Epinephrine
5.26	Single	8GGT	Epinephrine	8GGT-β₂-Epinephrine
5.26	Single	8HNM	VUF11222	8HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
5.26	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Single	8JLN	T1AM	8JLN-TA1-T1AM-Gs/&β;1/&γ;2
5.26	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
5.26	Single	8JSP	Ulotaront	8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2
5.26	Single	8THK	A61603	8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26	Single	8THL	Epinephrine	8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/&β;1/&γ;2
5.26	Single	8UNQ	Epinephrine	8UNQ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26	Single	8UNR	Epinephrine	8UNR-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26	Single	8UNS	Epinephrine	8UNS-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26	Single	8UNZ	Epinephrine	8UNZ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2
5.26	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.26	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	5ht1e_on	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2
5.26	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6WH4-5-HT_2A-Methiothepin 7VOE-5-HT_2A-Aripiprazole 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 6A93-5-HT_2A-Risperidone
5.26	Consensus	5ht5_on	Orthosteric Ligand	5ht5a_on
5.26	Consensus	5ht5a_on	Orthosteric Ligand	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
5.26	Consensus	alpha2b_on	Orthosteric Ligand	6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2
5.26	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
5.26	Consensus	d1_on_allo	Orthosteric Ligand	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
5.26	Consensus	d3_on	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
5.26	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
5.26	Consensus	gs_tar	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
5.26	Consensus	sensory_off	Orthosteric Ligand	opsin_off
5.13	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
5.00	Single	1HZX	11-cis-Retinal	1HZX-Rhodopsin-11-cis-Retinal
5.00	Single	2VT4	Cyanopindolol	2VT4-β₁-Cyanopindolol
5.00	Single	2Y01	Dobutamine	2Y01-β₁-Dobutamine
5.00	Single	2Y02	Carmoterol	2Y02-β₁-Carmoterol
5.00	Single	2Y04	Salbutamol	2Y04-β₁-Salbutamol
5.00	Single	2YCY	Cyanopindolol	2YCY-β₁-Cyanopindolol
5.00	Single	3EML	ZM241385	3EML-A_2A-ZM241385
5.00	Single	3NY8	ICI 118-551	3NY8-β₂-ICI 118-551
5.00	Single	3NYA	(S)-Alprenolol	3NYA-β₂-(S)-Alprenolol
5.00	Single	3ZPQ	4-(piperazin-1- yl)-1H-indole	3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na
5.00	Single	3ZPR	4-methyl-2-(piperazin-1-yl)	3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
5.00	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
5.00	Single	4EIY	ZM241385	4EIY-A_2A-ZM241385-Na
5.00	Single	4GBR	(S)-Carazolol	4GBR-β₂-(S)-Carazolol
5.00	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
5.00	Single	5DHG	PubChem 25001412	5DHG-NOP-PubChem 25001412
5.00	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
5.00	Single	5JQH	(S)-Carazolol	5JQH-β₂-(S)-Carazolol
5.00	Single	5K2A	ZM241385	5K2A-A_2A-ZM241385-Na
5.00	Single	5OLG	ZM241385	5OLG-A_2A-ZM241385-Na
5.00	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
5.00	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
5.00	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
5.00	Single	5UEN	DU172	5UEN-A₁-DU172
5.00	Single	5UIG	J3.651.884G	5UIG-A_2A-J3.651.884G
5.00	Single	5VRA	ZM241385	5VRA-A_2A-ZM241385-Na
5.00	Single	6DRX	Lisuride	6DRX-5-HT_2B-Lisuride
5.00	Single	6DRZ	Methysergide	6DRZ-5-HT_2B-Methysergide
5.00	Single	6FFH	Fenobam	6FFH-mGlu₅-Fenobam
5.00	Single	6GPS	MK0812	6GPS-CCR2-MK0812
5.00	Single	6H7M	Salbutamol	6H7M-β₁-Salbutamol
5.00	Single	6K42	Dexmedetomidine	6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
5.00	Single	6LPJ	ZM241385	6LPJ-A_2A-ZM241385-Na
5.00	Single	6LPK	ZM241385	6LPK-A_2A-ZM241385-Na
5.00	Single	6PRZ	(S)-Alprenolol	6PRZ-β₂-(S)-Alprenolol
5.00	Single	6PS0	(S)-Carazolol	6PS0-β₂-(S)-Carazolol
5.00	Single	6PS1	Timolol	6PS1-β₂-Timolol
5.00	Single	6PS2	(S)-Alprenolol	6PS2-β₂-(S)-Alprenolol
5.00	Single	6S0L	ZM241385	6S0L-A_2A-ZM241385
5.00	Single	6TOT	Lemborexant	6TOT-OX₁-Lemborexant
5.00	Single	7BTS	L-Epinephrine	7BTS-β₁-L-Epinephrine
5.00	Single	7BU6	L-Norepinephrine	7BU6-β₁-L-Norepinephrine
5.00	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/&β;1/&γ;2
5.00	Single	7E32	Serotonin	7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2
5.00	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.00	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
5.00	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
5.00	Single	7LJC	PubChem 86764103	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
5.00	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
5.00	Single	7RBT	PubChem 163183774	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	7S0G	Isoprenaline	7S0G-β₁-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
5.00	Single	7T2G	Mitragynine pseudoindoxyl	7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
5.00	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
5.00	Single	7UM5	5-CT	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
5.00	Single	7UM6	Lisuride	7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
5.00	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/&β;1/&γ;2
5.00	Single	7VH0	Ramelteon	7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
5.00	Single	7WC7	Lisuride	7WC7-5-HT_2A-Lisuride
5.00	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
5.00	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
5.00	Single	7XJH	Isoproterenol	7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
5.00	Single	7XTC	5-CT	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
5.00	Single	8CIC	Etrumadenant	8CIC-A_2A-Etrumadenant-Na
5.00	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
5.00	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
5.00	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
5.00	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
5.00	Single	8GE3	Epinephrine	8GE3-β₂-Epinephrine-Gs/&β;1/&γ;2
5.00	Single	8GEB	Epinephrine	8GEB-β₂-Epinephrine-Gs/&β;1/&γ;2
5.00	Single	8GEE	Epinephrine	8GEE-β₂-Epinephrine-Gs/&β;1/&γ;2
5.00	Single	8GEH	Epinephrine	8GEH-β₂-Epinephrine-Gs/&β;1/&γ;2
5.00	Single	8GFW	Epinephrine	8GFW-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GFX	Epinephrine	8GFX-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GFY	Epinephrine	8GFY-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GFZ	Epinephrine	8GFZ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GG0	Epinephrine	8GG0-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GG1	Epinephrine	8GG1-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GG2	Epinephrine	8GG2-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GG6	Epinephrine	8GG6-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GGB	Epinephrine	8GGB-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GGJ	Epinephrine	8GGJ-β₂-Epinephrine
5.00	Single	8GGN	Epinephrine	8GGN-β₂-Epinephrine
5.00	Single	8GGO	Epinephrine	8GGO-β₂-Epinephrine
5.00	Single	8GGU	Epinephrine	8GGU-β₂-Epinephrine
5.00	Single	8IRT	Rotigotine	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2
5.00	Single	8JJO	Alprenolol	8JJO-β₂-Alprenolol
5.00	Single	8JLJ	T1AM	8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
5.00	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
5.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
5.00	Single	8UNM	Epinephrine	8UNM-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8UNN	Epinephrine	8UNN-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8UNP	Epinephrine	8UNP-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
5.00	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
5.00	Single	8WC7	ZH8667	8WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	8X63	Mepyramine	8X63-H₁-Mepyramine
5.00	Single	8X64	Desloratadine	8X64-H₁-Desloratadine
5.00	Consensus	5ht1a_on	Orthosteric Ligand	8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2
5.00	Consensus	5ht1d_on	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2
5.00	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
5.00	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
5.00	Consensus	5ht7_on	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
5.00	Consensus	a2_off	Orthosteric Ligand	a2a_off
5.00	Consensus	a2a_off	Orthosteric Ligand	8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 5UIG-A_2A-J3.651.884G 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-PubChem 168451710 5K2D-A_2A-ZM241385
5.00	Consensus	adrenergic_on	Orthosteric Ligand	beta_on alpha_on
5.00	Consensus	alpha2_on	Orthosteric Ligand	alpha2a_on alpha2b_on
5.00	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
5.00	Consensus	alpha_on	Orthosteric Ligand	alpha1_on alpha2_on
5.00	Consensus	amine_on	Orthosteric Ligand	adrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
5.00	Consensus	d5_on	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Consensus	dopamine_on	Orthosteric Ligand	d3_on d2_on d5_on d1_on
5.00	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
5.00	Consensus	gi_5ht	Orthosteric Ligand	7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT_5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2
5.00	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.00	Consensus	gq_amine	Orthosteric Ligand	gq_muscarinic gq_histamine
5.00	Consensus	m2_on_allo	Orthosteric Ligand	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.00	Consensus	muscarinic_on	Orthosteric Ligand	m2_on m3_on m4_on m1_on
5.00	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
5.00	Consensus	tar_on	Orthosteric Ligand	ta1_on
4.88	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
4.76	Single	2RH1	(S)-Carazolol	2RH1-β₂-(S)-Carazolol
4.76	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
4.76	Single	2Y03	Isoprenaline	2Y03-β₁-Isoprenaline
4.76	Single	2YCW	(S)-Carazolol	2YCW-β₁-(S)-Carazolol
4.76	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
4.76	Single	4WW3	All-trans-retinal	4WW3-Rhodopsin-All-trans-retinal
4.76	Single	4ZJ8	Suvorexant	4ZJ8-OX₁-Suvorexant
4.76	Single	5C1M	BU72	5C1M-μ-BU72
4.76	Single	5D6L	(S)-Carazolol	5D6L-β₂-(S)-Carazolol
4.76	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
4.76	Single	5NM2	ZM241385	5NM2-A_2A-ZM241385-Na
4.76	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
4.76	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
4.76	Single	5TVN	LSD	5TVN-5-HT_2B-LSD
4.76	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
4.76	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
4.76	Single	5WQC	EMPA	5WQC-OX₂-EMPA
4.76	Single	5X7D	(S)-Carazolol	5X7D-β₂-(S)-Carazolol-PubChem 129318963
4.76	Single	5XPR	Bosentan	5XPR-ET_B-Bosentan
4.76	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
4.76	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
4.76	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/&β;1/&γ;2
4.76	Single	6E67	BI167107	6E67-β₂-BI167107-Gs (fused)
4.76	Single	6GPX	MK0812	6GPX-CCR2-MK0812
4.76	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
4.76	Single	6LPL	ZM241385	6LPL-A_2A-ZM241385-Na
4.76	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
4.76	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
4.76	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
4.76	Single	6PS3	(S)-Carvedilol	6PS3-β₂-(S)-Carvedilol
4.76	Single	6PS6	Timolol	6PS6-β₂-Timolol
4.76	Single	6S0Q	ZM241385	6S0Q-A_2A-ZM241385
4.76	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
4.76	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
4.76	Single	6WQA	ZM241385	6WQA-A_2A-ZM241385-Na
4.76	Single	6Z4S	SR48692	6Z4S-NTS₁-SR48692
4.76	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
4.76	Single	7BVQ	(S)-Carazolol	7BVQ-β₁-(S)-Carazolol
4.76	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
4.76	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/&β;1/&γ;2
4.76	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
4.76	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
4.76	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.76	Single	7RM5	ZM241385	7RM5-A_2A-ZM241385-Na
4.76	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2
4.76	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/&β;1/&γ;2
4.76	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
4.76	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
4.76	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
4.76	Single	7WC6	LSD	7WC6-5-HT_2A-LSD
4.76	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
4.76	Single	7XKA	Epinephrine	7XKA-β₂-Epinephrine
4.76	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
4.76	Single	8DZR	GR89,696	8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
4.76	Single	8FYN	ZM241385	8FYN-A_2A-ZM241385-Na
4.76	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
4.76	Single	8QOT	Nanobody E	8QOT-μ-Nanobody E
4.76	Single	8UNY	Epinephrine	8UNY-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.76	Consensus	5ht1_on	Orthosteric Ligand	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
4.76	Consensus	5ht2b_off	Orthosteric Ligand	6DRZ-5-HT_2B-Methysergide 6DRX-5-HT_2B-Lisuride
4.76	Consensus	a1_on_allo	Orthosteric Ligand	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
4.76	Consensus	adrenergic_off	Orthosteric Ligand	beta_off alpha_off
4.76	Consensus	alpha2a_on	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
4.76	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
4.76	Consensus	amine_off	Orthosteric Ligand	adrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
4.76	Consensus	beta2_off	Orthosteric Ligand	6PS2-β₂-(S)-Alprenolol 6PS3-β₂-(S)-Carvedilol 6PS5-β₂-(S)-Propranolol 6PS6-β₂-Timolol 2RH1-β₂-(S)-Carazolol 6PS4-β₂-ICI 118-551 3NY9-β₂-PubChem 913103
4.76	Consensus	beta2_on	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2
4.76	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
4.76	Consensus	beta_off	Orthosteric Ligand	beta1_off beta2_off
4.76	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
4.76	Consensus	ccr2_off_allo	Other Ligand	5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
4.76	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
4.76	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
4.76	Consensus	d4_off	Orthosteric Ligand	5WIU-D₄-Nemonapride
4.76	Consensus	d4_off_allo	Orthosteric Ligand	5WIV-D₄-Nemonapride-Na
4.76	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
4.76	Consensus	ep_off	Orthosteric Ligand	ep4_off
4.76	Consensus	gi_adrenergic	Orthosteric Ligand	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
4.76	Consensus	go_amine	Orthosteric Ligand	go_adrenergic go_muscarinic go_5ht
4.76	Consensus	gq_muscarinic	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
4.76	Consensus	gs_adrenergic	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJI-β₃-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
4.76	Consensus	m1_on	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
4.76	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	3P0G	BI167107	3P0G-β₂-BI167107
4.55	Single	3PDS	Hydroxybenzylisoproterenol	3PDS-β₂-Hydroxybenzylisoproterenol
4.55	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/&β;1/&γ;2
4.55	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
4.55	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
4.55	Single	4IAQ	Dihydroergotamine	4IAQ-5-HT_1B-Dihydroergotamine
4.55	Single	4LDL	Hydroxybenzylisoproterenol	4LDL-β₂-Hydroxybenzylisoproterenol
4.55	Single	4OO9	Mavoglurant	4OO9-mGlu₅-Mavoglurant
4.55	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
4.55	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
4.55	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
4.55	Single	5D5A	(S)-Carazolol	5D5A-β₂-(S)-Carazolol
4.55	Single	5D5B	(S)-Carazolol	5D5B-β₂-(S)-Carazolol
4.55	Single	5V54	Methiothepin	5V54-5-HT_1B-Methiothepin
4.55	Single	5X93	K-8794	5X93-ET_B-K-8794
4.55	Single	5XRA	AM11542	5XRA-CB₁-AM11542
4.55	Single	6E59	L-760735	6E59-NK₁-L-760735
4.55	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
4.55	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
4.55	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
4.55	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
4.55	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
4.55	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
4.55	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/&β;1/&γ;2
4.55	Single	6OIJ	Iperoxo	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
4.55	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
4.55	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
4.55	Single	6Z4Q	SR142948A	6Z4Q-NTS₁-SR142948A
4.55	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
4.55	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/&β;1/&γ;2
4.55	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2
4.55	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
4.55	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2
4.55	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/&β;1/&γ;2
4.55	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/&β;1/&γ;2
4.55	Single	7P2L	4YI	7P2L-mGlu₅-4YI
4.55	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
4.55	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
4.55	Single	7U2L	PubChem 163201242	7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
4.55	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2
4.55	Single	7W41	PD176252	7W41-BB₂-PD176252
4.55	Single	7W6P	W96	7W6P-α_2a-W96-Go/&β;1/&γ;2
4.55	Single	7W7E	W58	7W7E-α_2a-W58-Go/&β;1/&γ;2
4.55	Single	7WV9	PubMed 104895	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
4.55	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
4.55	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2
4.55	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/&β;1/&γ;2
4.55	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/&β;1/&γ;2
4.55	Single	8E0G	BU72	8E0G-μ-BU72
4.55	Single	8EF5	Fentanyl	8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
4.55	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/&β;1/&γ;2
4.55	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2
4.55	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
4.55	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
4.55	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2
4.55	Single	8IRU	Rotigotine	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
4.55	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	8JD0	J9R	8JD0-mGlu2; mGlu3-Glutamate-J9R
4.55	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.55	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
4.55	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
4.55	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/&β;1/&γ;2
4.55	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/&β;1/&γ;2
4.55	Single	8JXX	Clobenpropit	8JXX-H₄-Clobenpropit-Gi1/&β;1/&γ;2
4.55	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
4.55	Single	8TAO	CDPPB	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.55	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/&β;1/&γ;2
4.55	Consensus	5ht1_off	Orthosteric Ligand	5ht1b_off
4.55	Consensus	5ht1b_off	Orthosteric Ligand	5V54-5-HT_1B-Methiothepin
4.55	Consensus	5ht1b_on	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
4.55	Consensus	5ht5_off	Orthosteric Ligand	5ht5a_off
4.55	Consensus	5ht_off	Orthosteric Ligand	5ht2_off 5ht5_off 5ht1_off
4.55	Consensus	a2_on	Orthosteric Ligand	a2a_on a2b_on
4.55	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
4.55	Consensus	alpha1b_off	Orthosteric Ligand	7B6W-α_1b-Cyclazosin
4.55	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
4.55	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
4.55	Consensus	beta1_off	Orthosteric Ligand	2VT4-β₁-Cyanopindolol 2YCZ-β₁-Iodocyanopindolol
4.55	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
4.55	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
4.55	Consensus	dopamine_off	Orthosteric Ligand	d3_off d2_off d4_off
4.55	Consensus	gi_dopamine	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
4.55	Consensus	gi_muscarinic	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
4.55	Consensus	go_adrenergic	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
4.55	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A_2A-NECA-Gs/&β;1/&γ;1 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2
4.55	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
4.55	Consensus	h1_off	Orthosteric Ligand	3RZE-H₁-Cidoxepin 8X5Y-H₁-Astemizole 8X63-H₁-Mepyramine 8X64-H₁-Desloratadine
4.55	Consensus	histamine_off	Orthosteric Ligand	h1_off
4.55	Consensus	nk1_off	Orthosteric Ligand	6J20-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
4.55	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
4.55	Consensus	sst4_on	Orthosteric Ligand	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
4.35	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
4.35	Single	3D4S	Timolol Maleate	3D4S-β₂-Timolol Maleate
4.35	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
4.35	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
4.35	Single	4LDE	BI167107	4LDE-β₂-BI167107
4.35	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
4.35	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
4.35	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
4.35	Single	6C1R	PMX53	6C1R-C5a₁-PMX53-Avacopan; Na
4.35	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
4.35	Single	6DRY	Methylergonovine	6DRY-5-HT_2B-Methylergonovine
4.35	Single	6H7N	(S)-Xamoterol	6H7N-β₁-(S)-Xamoterol
4.35	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
4.35	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
4.35	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
4.35	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
4.35	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
4.35	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
4.35	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.35	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
4.35	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2
4.35	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
4.35	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
4.35	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
4.35	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
4.35	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
4.35	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
4.35	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
4.35	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.35	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2
4.35	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
4.35	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
4.35	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
4.35	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
4.35	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
4.35	Single	8JWY	PubChem 168451710	8JWY-A_2A-PubChem 168451710
4.35	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
4.35	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
4.35	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
4.35	Consensus	beta1_on	Orthosteric Ligand	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
4.35	Consensus	blt1_off	Orthosteric Ligand	7K15-BLT₁-MKD046-Na
4.35	Consensus	blt_off	Orthosteric Ligand	blt1_off
4.35	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
4.35	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
4.35	Consensus	go_5ht	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
4.35	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
4.35	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
4.35	Consensus	nts1_off	Orthosteric Ligand	6Z4Q-NTS₁-SR142948A 6Z4S-NTS₁-SR48692
4.35	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
4.35	Consensus	nts_off	Orthosteric Ligand	nts1_off
4.35	Consensus	nts_on	Orthosteric Ligand	nts1_on
4.35	Consensus	opioid_off	Orthosteric Ligand	kop_off mop_off nop_off dop_off
4.35	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.17	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
4.17	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
4.17	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
4.17	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
4.17	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
4.17	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
4.17	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
4.17	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
4.17	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/&β;1/&γ;2
4.17	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
4.17	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
4.17	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
4.17	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
4.17	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
4.17	Single	7EZC	UKA	7EZC-A_2A-UKA
4.17	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2
4.17	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
4.17	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
4.17	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.17	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
4.17	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
4.17	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
4.17	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2
4.17	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/&β;1/&γ;2
4.17	Single	8ID8	TUG-891	8ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
4.17	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
4.17	Consensus	5ht5a_off	Orthosteric Ligand	7UM4-5-HT_5A-AS2674723
4.17	Consensus	beta1_off_allo	Orthosteric Ligand	4BVN-β₁-Cyanopindolol-Na
4.17	Consensus	c5a1_off_ortoallo	Orthosteric Ligand	6C1Q-C5a₁-PMX53-NDT9513727 6C1R-C5a₁-PMX53-Avacopan; Na
4.17	Consensus	cckb_on	Orthosteric Ligand	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
4.17	Consensus	endothelin_off	Orthosteric Ligand	etb_off
4.17	Consensus	etb_off	Orthosteric Ligand	5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500 5X93-ET_B-K-8794
4.17	Consensus	ffa4_on_allo	Orthosteric Ligand	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
4.17	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
4.17	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00	Single	3NY9	PubChem 913103	3NY9-β₂-PubChem 913103
4.00	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
4.00	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
4.00	Single	6PT3	DPI-287	6PT3-δ-DPI-287
4.00	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
4.00	Single	7XY6	PubChem 11717831	7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
4.00	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
4.00	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
4.00	Consensus	class-d_off	Orthosteric Ligand	ste2_off
4.00	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
4.00	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
4.00	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
4.00	Consensus	gs_bombesin	Orthosteric Ligand	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85	Single	4AMJ	(S)-Carvedilol	4AMJ-β₁-(S)-Carvedilol
3.85	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
3.85	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
3.85	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
3.85	Single	7QA8	Peptide	7QA8-STE2-Peptide
3.85	Single	7QA8	Peptide	7QA8-STE2-Peptide
3.85	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
3.85	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
3.85	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
3.85	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
3.85	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
3.85	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
3.85	Single	8G59	TUG-891	8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
3.85	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
3.85	Consensus	class-d_off	Orthosteric Ligand	ste2_off
3.85	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
3.85	Consensus	mop_off	Orthosteric Ligand	7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
3.85	Consensus	nmur1_on	Orthosteric Ligand	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
3.85	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
3.70	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
3.70	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
3.70	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.70	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
3.70	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
3.70	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
3.70	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
3.70	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off alpha1b_off
3.70	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
3.70	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
3.70	Consensus	sst_off	Orthosteric Ligand	sst2_off
3.57	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.57	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1
3.57	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
3.57	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
3.57	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;2
3.57	Consensus	gi_formylpeptide	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
3.57	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
3.57	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
3.57	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
3.45	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
3.45	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
3.45	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
3.45	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
3.45	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
3.45	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
3.45	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.45	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
3.45	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
3.45	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
3.45	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
3.45	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
3.45	Consensus	nmur2_on	Orthosteric Ligand	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45	Consensus	nmur_on	Orthosteric Ligand	nmur1_on nmur2_on
3.45	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
3.45	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.33	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
3.33	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
3.33	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
3.33	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
3.33	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
3.33	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
3.33	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
3.33	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
3.33	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
3.33	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.33	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
3.33	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Consensus	bk1_on	Orthosteric Ligand	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.33	Consensus	bombesin_on	Orthosteric Ligand	bb2_on bb1_on
3.33	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
3.33	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
3.33	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.33	Consensus	gs_neuromedin	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.33	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.23	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.23	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.23	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
3.23	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
3.23	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
3.23	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
3.23	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
3.23	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.23	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
3.23	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
3.23	Consensus	bb1_on	Orthosteric Ligand	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.23	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
3.23	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
3.23	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
3.23	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
3.12	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
3.12	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
3.12	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.12	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
3.12	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
3.12	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.12	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
3.12	Consensus	etb_on	Orthosteric Ligand	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
3.12	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
3.12	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.03	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
3.03	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.03	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
3.03	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
3.03	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
3.03	Single	7VGX	Neuropeptide Y	7VGX-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.03	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
3.03	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
3.03	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
3.03	Consensus	gs_endothelin	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.94	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
2.94	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
2.94	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
2.94	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
2.94	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
2.86	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
2.86	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
2.86	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.86	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
2.86	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
2.86	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
2.86	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
2.78	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
2.78	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
2.78	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
2.70	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
2.70	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
2.70	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
2.70	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.70	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
2.70	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
2.70	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
2.50	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
2.50	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
2.44	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
2.38	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K74	R:R:P56	8.36	1	Yes	No	5	5	1	2
R:R:P56	R:R:S157	7.13	1	No	Yes	5	5	2	2
R:R:K74	R:R:R78	9.9	1	Yes	Yes	5	4	1	1
R:R:K74	R:R:S157	4.59	1	Yes	Yes	5	5	1	2
R:R:E287	R:R:K74	6.75	0	No	Yes	3	5	2	1
L:L:?1	R:R:K74	4.79	1	Yes	Yes	0	5	0	1
R:R:R78	R:R:S157	9.22	1	Yes	Yes	4	5	1	2
R:R:R78	R:R:Y179	9.26	1	Yes	Yes	4	8	1	2
R:R:E403	R:R:R78	6.98	1	Yes	Yes	5	4	2	1
R:R:K405	R:R:R78	9.9	1	Yes	Yes	4	4	1	1
L:L:?1	R:R:R78	5.16	1	Yes	Yes	0	4	0	1
R:R:S157	R:R:Y179	7.63	1	Yes	Yes	5	8	2	2
R:R:S159	R:R:S181	6.52	1	Yes	No	9	8	1	2
R:R:S159	R:R:Y230	6.36	1	Yes	Yes	9	7	1	1
L:L:?1	R:R:S159	8.92	1	Yes	Yes	0	9	0	1
R:R:A180	R:R:K405	6.42	0	No	Yes	6	4	2	1
R:R:D202	R:R:T182	8.67	1	Yes	Yes	8	8	2	1
R:R:T182	R:R:Y230	3.75	1	Yes	Yes	8	7	1	1
R:R:D312	R:R:T182	5.78	1	Yes	Yes	8	8	2	1
L:L:?1	R:R:T182	5.01	1	Yes	Yes	0	8	0	1
R:R:D202	R:R:Y230	6.9	1	Yes	Yes	8	7	2	1
R:R:G231	R:R:Y230	4.35	0	No	Yes	8	7	2	1
R:R:F284	R:R:Y230	4.13	1	Yes	Yes	8	7	2	1
R:R:S311	R:R:Y230	5.09	1	No	Yes	8	7	2	1
R:R:S313	R:R:Y230	3.82	1	No	Yes	6	7	1	1
L:L:?1	R:R:Y230	31.85	1	Yes	Yes	0	7	0	1
R:R:F284	R:R:S311	13.21	1	Yes	No	8	8	2	2
R:R:S313	R:R:W314	6.18	1	No	Yes	6	7	1	2
L:L:?1	R:R:S313	3.82	1	Yes	No	0	6	0	1
R:R:F408	R:R:K405	6.2	0	Yes	Yes	7	4	2	1
L:L:?1	R:R:K405	8.38	1	Yes	Yes	0	4	0	1
R:R:A183	R:R:S159	3.42	0	No	Yes	7	9	2	1
L:L:?1	R:R:G158	2.9	1	Yes	No	0	4	0	1
R:R:G75	R:R:K74	1.74	0	No	Yes	5	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
100.00	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
100.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
100.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
100.00	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
100.00	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
100.00	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
100.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
100.00	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
100.00	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
100.00	Single	7DD5	Ca3	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
100.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
100.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
100.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
100.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
100.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00	Single	7EB2	Baclofen	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
100.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
100.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
100.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
100.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
100.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
100.00	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00	Single	7FII	hCG	7FII-LH-hCG-6fuf
100.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
100.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
100.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
100.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
100.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
100.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
100.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
100.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
100.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
100.00	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
100.00	Single	7XW7	K1-70	7XW7-TSH-K1-70
100.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
100.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
100.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
100.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
100.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
100.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
100.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
100.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
100.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
100.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
100.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
100.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
100.00	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-J9R
100.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
100.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
100.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
100.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
100.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
100.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
100.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
100.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
100.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
100.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
100.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
100.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
100.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
100.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
100.00	Consensus	fsh_on_allo	Orthosteric Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
100.00	Consensus	gabab_off	Orthosteric Ligand	7C7S-GABA_B1, GABA_B2-CGP54626 7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid 6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
100.00	Consensus	gabab_on	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
100.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
100.00	Consensus	gi_gaba	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	gphr_on	Orthosteric Ligand	lh_on tsh_on
100.00	Consensus	gs_gphr	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00	Consensus	gs_protein	Orthosteric Ligand	gs_gphr
100.00	Consensus	lh_on	Orthosteric Ligand	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00	Consensus	lh_on_allo	Orthosteric Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
100.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
100.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
100.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
100.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
100.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
100.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
100.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
100.00	Consensus	smo_off_allo	Other Ligand	6D32-SMO-Cyclopamine-Cyclopamine
100.00	Consensus	tsh_on	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2
100.00	Consensus	tsh_on_allo	Orthosteric Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
50.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
33.33	Single	8HS2	Fab046	8HS2-GPR20-Fab046
25.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
25.00	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00	Single	7UTZ	TR1402	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
25.00	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
25.00	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
20.00	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
20.00	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/&β;1/&γ;2
20.00	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
20.00	Single	8I2G	Glycoprotein hormones alpha chain	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
14.29	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
14.29	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
14.29	Single	6LI0	GTPL9804	6LI0-GPR52-GTPL9804
14.29	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
14.29	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
14.29	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
12.50	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
12.50	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
12.50	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
12.50	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50	Consensus	go_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.50	Consensus	go_protein	Orthosteric Ligand	go_chemokine
12.50	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
11.11	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
11.11	Single	5U09	Taranabant	5U09-CB₁-Taranabant
11.11	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.11	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
11.11	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
11.11	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
11.11	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
11.11	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
11.11	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
11.11	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
11.11	Single	8HMP	PubChem 69921479	8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Consensus	class-f_off	Orthosteric Ligand	smo_off
11.11	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
11.11	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
11.11	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
10.00	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
10.00	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
10.00	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.00	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
10.00	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
10.00	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
10.00	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
10.00	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
10.00	Consensus	gi_class-f	Orthosteric Ligand	gi_frizzled
10.00	Consensus	gi_frizzled	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
10.00	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
10.00	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
9.09	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
9.09	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
9.09	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
9.09	Single	6D27	CAY10471	6D27-DP₂-CAY10471
9.09	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.09	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
9.09	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
9.09	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
9.09	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
9.09	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
9.09	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
9.09	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
9.09	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
9.09	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.09	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
9.09	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
9.09	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.33	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
8.33	Single	5C1M	BU72	5C1M-μ-BU72
8.33	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.33	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.33	Single	7C4S	S1P	7C4S-S1P₃-S1P
8.33	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
8.33	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
8.33	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.33	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
8.33	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
8.33	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
8.33	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.69	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
7.69	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
7.69	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
7.69	Single	5V56	TC114	5V56-SMO-TC114
7.69	Single	5V57	TC114	5V57-SMO-TC114
7.69	Single	6OS1	TRV026	6OS1-AT₁-TRV026
7.69	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
7.69	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.69	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
7.69	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
7.69	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.69	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.69	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.69	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
7.69	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
7.69	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
7.69	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Single	8E0G	BU72	8E0G-μ-BU72
7.69	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
7.69	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
7.69	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.69	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
7.69	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
7.69	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
7.69	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.69	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
7.14	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
7.14	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
7.14	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
7.14	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
7.14	Single	6OS2	TRV026	6OS2-AT₁-TRV026
7.14	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.14	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
7.14	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
7.14	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.14	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
7.14	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
7.14	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.14	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
7.14	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
7.14	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
7.14	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
7.14	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
7.14	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
7.14	Consensus	dp_off	Orthosteric Ligand	dp2_off
7.14	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
7.14	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
7.14	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.14	Consensus	nts_on	Orthosteric Ligand	nts1_on
7.14	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
7.14	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.67	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
6.67	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
6.67	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
6.67	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
6.67	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
6.67	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
6.67	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6.67	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
6.67	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
6.67	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
6.67	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.67	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.67	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
6.25	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
6.25	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
6.25	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
6.25	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
6.25	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
6.25	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
6.25	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
6.25	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
6.25	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
6.25	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
6.25	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
6.25	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
5.88	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
5.88	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.88	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.88	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
5.88	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
5.88	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
5.88	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.88	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
5.88	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.88	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.88	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.88	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
5.88	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.88	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.88	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.88	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
5.88	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
5.56	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
5.56	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.56	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
5.56	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
5.56	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
5.56	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
5.56	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
5.56	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.56	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
5.56	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.56	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.56	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
5.56	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
5.26	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
5.26	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
5.26	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
5.26	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
5.26	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
5.26	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.26	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
5.26	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
5.26	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.26	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
5.26	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
5.26	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
5.26	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
5.26	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
5.00	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
5.00	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
5.00	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
5.00	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
5.00	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.00	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
5.00	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
5.00	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
5.00	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
5.00	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
5.00	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
5.00	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
5.00	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
5.00	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.00	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
5.00	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
5.00	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.76	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.76	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
4.76	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.76	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.76	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.76	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.76	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.76	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.76	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.76	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.76	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
4.76	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
4.76	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.76	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
4.76	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
4.55	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
4.55	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
4.55	Single	6FJ3	PTH	6FJ3-PTH1-PTH
4.55	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.55	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.55	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
4.55	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
4.55	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
4.55	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.55	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
4.55	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
4.55	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.55	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.55	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
4.55	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.55	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.35	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
4.35	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
4.35	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
4.35	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.35	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
4.35	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
4.35	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
4.35	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.35	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.35	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.35	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
4.35	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.35	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
4.35	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
4.35	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.35	Consensus	go_class-b1	Orthosteric Ligand	go_crf
4.35	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.35	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.17	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
4.17	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
4.17	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.17	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
4.17	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.17	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
4.17	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.17	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
4.17	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
4.17	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
4.17	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
4.17	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
4.17	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
4.17	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.17	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.17	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.17	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
4.17	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
4.17	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
4.17	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.00	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
4.00	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.00	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
4.00	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
4.00	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.00	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
4.00	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.00	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
4.00	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
4.00	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.00	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
4.00	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.00	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
3.85	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.85	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
3.85	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.85	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.85	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.85	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.85	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
3.85	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
3.70	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
3.70	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.70	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.70	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.70	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.70	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
3.57	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.57	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.57	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.57	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.57	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.57	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.57	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.57	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.57	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
3.57	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.45	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.45	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.45	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
3.45	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
3.33	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.33	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.23	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.23	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
3.23	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.12	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
3.12	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
3.12	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.03	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
3.03	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
3.03	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.94	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.94	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.86	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB	8JD6
Class	C
SubFamily	Aminoacid
Type	Metabotropic glutamate
SubType	mGlu4; mGlu4
Species	Homo sapiens
Ligand	Phosphoserine
Other Ligand(s)	N-(3-chlorophenyl)pyridine-2-carboxamide
Protein Partners	Gi3/Beta1/Gamma2
PDB Resolution	3.4
Date	2023-06-21
D.O.I.	10.1038/s41422-023-00830-2

Net Summary
I_min	3.64
Number of Linked Nodes	2015
Number of Links	2274
Number of Hubs	305
Number of Links mediated by Hubs	1146
Number of Communities	61
Number of Nodes involved in Communities	381
Number of Links involved in Communities	513

Path Summary
Number Of Nodes in MetaPath	183
Number Of Links MetaPath	182
Number of Shortest Paths	3378065
Length Of Smallest Path	3
Average Path Length	35.8398
Length of Longest Path	108
Minimum Path Strength	1.215
Average Path Strength	7.07899
Maximum Path Strength	25.59
Minimum Path Correlation	0.8
Average Path Correlation	0.999466
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	10.7143
Average % Of Corr. Nodes	75.2167
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.8382
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	BK0
PDB Residues	X:X:?1
Environment Details	Open EMBL-EBI Page
Code	BK0
Name	N-(3-chlorophenyl)pyridine-2-carboxamide
Synonyms
Identifier	~{N}-(3-chlorophenyl)pyridine-2-carboxamide
Formula	C12 H9 Cl N2 O
Molecular Weight	232.666
SMILES	c1ccnc(c1)C(=O)Nc2cccc(c2)Cl
PubChem	836002
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	0
Total Bonds	26
Total Aromatic Bonds	12


Code	SEP
PDB Residues	M:M:?1 L:L:?1
Environment Details	Open EMBL-EBI Page
Code	SEP
Name	Dexfosfoserine
Synonyms	PHOSPHONOSERINE
Identifier	(2S)-2-amino-3-phosphonooxy-propanoic acid
Formula	C3 H8 N O6 P
Molecular Weight	185.072
SMILES	C([C@@H](C(=O)O)N)OP(=O)(O)O
PubChem	68841
Formal Charge	0
Total Atoms	19
Total Chiral Atoms	1
Total Bonds	18
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	S
Protein	Receptor
UniProt	Q14833
Sequence	>8JD6_Chain_S N S I R I D G D I T L G G L F P V H G R G S E G K P C G E L K K E K G I H R L E A M L F A L D R I N N D P D L L P N I T L G A R I L D T C S R D T H A L E Q S L T F V Q A L E R V V G V I G A S G S S V S I M V A N I L R L F K I P Q I S Y A S T A P D L S D N S R Y D F F S R V V P S D T Y Q A Q A M V D I V R A L K W N Y V S T V A S E G S Y G E S G V E A F I Q K S R E D G G V C I A Q S V K I P R E P K A G E F D K I I R R L L E T S N A R A V I I F A N E D D I R R V L E A A R R A N Q T G H F F W M G S D S W G S K I A P V L H L E E V A E G A V T I L P K R M S V R G F D R Y F S S R T L D N N R R N I W F A E F W E D N F H C K K K C T N R E R I G Q D S A Y E Q E G K V Q F V I D A V Y A M G H A L H A M H R D L C P G R V G L C P R M D P V D G T Q L L K Y I R N V N F S G I A G N P V T F N E N G D A P G R Y D I Y Q Y Q L R N D S A E Y K V I G S W T D H L H L R I E R M H W L P R S I C S L P C Q P G E R K K T V K G M P C C W H C E P C T G Y Q Y Q V D R Y T C K T C P Y D M R P T E N R T G C R P I P I I K L E W G S P W A V L P L F L A V V G I A A T L F V V I T F V R Y N D T P I V K A S G R E L S Y V L L A G I F L C Y A T T F L M I A E P D L G T C S L R R I F L G L G M S I S Y A A L L T K T N R I Y R I F E Q R F I S P A S Q L A I T F S L I S L Q L L G I C V W F V V D P S H S V V D F Q D Q R T L D P R F A R G V L K C D I S D L S L I C L L G Y S M L L M V T C T V Y A I K T R G V P E T F N E A K P I G F T M Y T T C I V W L A F I P I F F G T S Q S A D K L Y I Q T T T L T V S V S L S A S V S L G M L Y M P K V Y I I L F H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	Q14833
Sequence	>8JD6_Chain_R N S I R I D G D I T L G G L F P V H G R G S E G K P C G E L K K E K G I H R L E A M L F A L D R I N N D P D L L P N I T L G A R I L D T C S R D T H A L E Q S L T F V Q A L I E R V V G V I G A S G S S V S I M V A N I L R L F K I P Q I S Y A S T A P D L S D N S R Y D F F S R V V P S D T Y Q A Q A M V D I V R A L K W N Y V S T V A S E G S Y G E S G V E A F I Q K S R E D G G V C I A Q S V K I P R E P K A G E F D K I I R R L L E T S N A R A V I I F A N E D D I R R V L E A A R R A N Q T G H F F W M G S D S W G S K I A P V L H L E E V A E G A V T I L P K R M S V R G F D R Y F S S R T L D N N R R N I W F A E F W E D N F H C K L V K K C T N R E R I G Q D S A Y E Q E G K V Q F V I D A V Y A M G H A L H A M H R D L C P G R V G L C P R M D P V D G T Q L L K Y I R N V N F S G I A G N P V T F N E N G D A P G R Y D I Y Q Y Q L R A E Y K V I G S W T D H L H L R I E R M H W L P R S I C S L P C Q P G E R K K T V K G M P C C W H C E P C T G Y Q Y Q V D R Y T C K T C P Y D M R P T E N R T G C R P I P I I K L E W G S P W A V L P L F L A V V G I A A T L F V V I T F V R Y N D T P I V K A S G R E L S Y V L L A G I F L C Y A T T F L M I A E P D L G T C S L R R I F L G L G M S I S Y A A L L T K T N R I Y R I F E Q G K R S V S A P R F I S P A S Q L A I T F S L I S L Q L L G I C V W F V V D P S H S V V D F Q D Q R T L D P R F A R G V L K C D I S D L S L I C L L G Y S M L L M V T C T V Y A I K T R G V P E T F N E A K P I G F T M Y T T C I V W L A F I P I F F G T S Q S A D K L Y I Q T T T L T V S V S L S A S V S L G M L Y M P K V Y I I L F H P E Q N V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	G
Protein	G Protein γ Sub unit
UniProt	P59768
Sequence	>8JD6_Chain_G K V S K A A A D L M A Y C E A H A K E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	B
Protein	G Protein β Sub unit
UniProt	P62873
Sequence	>8JD6_Chain_B V G R I Q M R T R R T L R G H L A K I Y A M H W G T D S R L L V S A S Q D G K L I I W D S Y T T N K V H A I P L R S S W V M T C A Y A P S G N Y V A C G G L D N I C S I Y N L K T R E G N V R V S R E L A G H T G Y L S C C R F L D D N Q I V T S S G D T T C A L W D I E T G Q Q T T T F T G H T G D V M S L S L A P D T R L F V S G A C D A S A K L W D V R E G M C R Q T F T G H E S D I N A I C F F P N G N A F A T G S D D A T C R L F D L R A D Q E L M T Y S H D N I I C G I T S V S F S K S G R L L L A G Y D D F N C N V W D A L K A D R A G V L A G H D N R V S C L G V T D D G M A V A T G S W D S F L K I W N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	A
Protein	G Protein α Sub unit
UniProt	P08754
Sequence	>8JD6_Chain_A S A E D K A A V E R S K M I D R N L R E D G E K A A K E V K L L L L G A G E S G K N T I V K Q M K I I G I V E T H F T D K D L Y F K M F D V G A Q R S E R K K W I H C F E G V T A I I F C V A L S D Y D L V L A E D E E M N R M H A S M K L F D S I C N N K W F T E T S I I L F L N K K D L F E E K I K R S P L T I C Y P E Y T G S N T Y E E A A A Y I Q C Q F E D L N R R K D T K E I Y T H F T C S T D T K N V Q F V F D A V T D V I I K N N L K E C G L Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This network is also present in following consensuses:
	Id	Components
	mglu4_on	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
	gi_mglu	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JD4	C	Aminoacid	Metabotropic glutamate	mGlu2; mGlu4	Homo sapiens	Glutamate	-	-	2.9	2023-06-21	10.1038/s41422-023-00830-2
	8JD5	C	Aminoacid	Metabotropic glutamate	mGlu2; mGlu4	Homo sapiens	Glutamate	BQI; HZE; PEF	Gi1/&β;1/&γ;2	3.6	2023-06-21	10.1038/s41422-023-00830-2
	7E9H	C	Aminoacid	Metabotropic glutamate	mGlu4; mGlu4	Homo sapiens	Phosphoserine	-	Gi3/&β;1/&γ;2	4	2021-06-23	10.1038/s41586-021-03495-2
	8JD6	C	Aminoacid	Metabotropic glutamate	mGlu4; mGlu4	Homo sapiens	Phosphoserine	N-(3-chlorophenyl)pyridine-2-carboxamide	Gi3/&β;1/&γ;2	3.4	2023-06-21	10.1038/s41422-023-00830-2

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