psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G22	R:R:P23	4.06	No	No	0	3	3
2	R:R:G22	R:R:S114	3.71	No	No	0	3	5
3	R:R:F99	R:R:P23	8.67	Yes	No	0	9	3
4	R:R:E110	R:R:P23	9.43	No	No	0	6	3
5	R:R:N24	R:R:Q25	2.64	No	No	0	4	3
6	R:R:Q28	R:R:R26	12.85	No	No	0	4	5
7	R:R:F99	R:R:R26	8.55	Yes	No	0	9	5
8	R:R:A27	R:R:F348	2.77	No	Yes	0	3	5
9	R:R:Q28	R:R:R97	7.01	No	Yes	0	4	8
10	R:R:K29	R:R:N83	2.8	No	No	0	2	4
11	R:R:K29	R:R:Y96	16.72	No	Yes	2	2	4
12	R:R:K29	R:R:N345	8.39	No	No	2	2	7
13	R:R:D32	R:R:M92	4.16	No	No	0	6	7
14	R:R:D32	R:R:T93	5.78	No	No	0	6	9
15	R:R:I33	R:R:L94	2.85	No	Yes	0	4	9
16	R:R:I140	R:R:I33	5.89	No	No	0	7	4
17	R:R:I33	R:R:L431	4.28	No	No	0	4	6
18	R:R:I34	R:R:R97	3.76	No	Yes	23	6	8
19	R:R:I34	R:R:T139	3.04	No	No	23	6	4
20	R:R:I79	R:R:L35	4.28	No	No	0	7	9
21	R:R:L35	R:R:L94	5.54	No	Yes	0	9	9
22	R:R:I427	R:R:L35	2.85	No	No	0	9	9
23	R:R:F115	R:R:G36	4.52	Yes	No	0	5	6
24	R:R:G37	R:R:M75	3.49	No	Yes	2	7	5
25	R:R:G37	R:R:I98	5.29	No	Yes	2	7	4
26	R:R:L38	R:R:T101	2.95	No	No	0	7	7
27	R:R:F115	R:R:L38	3.65	Yes	No	0	5	7
28	R:R:L38	R:R:V154	2.98	No	Yes	0	7	8
29	R:R:F39	R:R:P40	4.33	Yes	Yes	2	5	4
30	R:R:F39	R:R:L72	9.74	Yes	Yes	2	5	7
31	R:R:F39	R:R:M75	6.22	Yes	Yes	2	5	5
32	R:R:F39	R:R:I98	2.51	Yes	Yes	2	5	4
33	R:R:F39	R:R:Y168	10.32	Yes	Yes	2	5	5
34	R:R:F39	R:R:V420	3.93	Yes	No	2	5	8
35	R:R:N65	R:R:P40	3.26	Yes	Yes	0	1	4
36	R:R:P40	R:R:W71	5.4	Yes	Yes	2	4	4
37	R:R:N103	R:R:P40	3.26	No	Yes	0	4	4
38	R:R:P40	R:R:T146	8.74	Yes	Yes	2	4	3
39	R:R:I41	R:R:Y64	3.63	Yes	Yes	2	7	3
40	R:R:I41	R:R:L72	2.85	Yes	Yes	2	7	7
41	R:R:D100	R:R:I41	12.59	Yes	Yes	2	7	7
42	R:R:F348	R:R:I41	3.77	Yes	Yes	2	5	7
43	R:R:C61	R:R:H42	4.42	No	Yes	2	1	2
44	R:R:H42	R:R:Y64	4.36	Yes	Yes	2	2	3
45	R:R:D100	R:R:H42	5.04	Yes	Yes	2	7	2
46	R:R:C102	R:R:H42	5.9	No	Yes	2	2	2
47	R:R:E351	R:R:H42	8.62	No	Yes	2	6	2
48	R:R:F43	R:R:R63	6.41	Yes	No	0	3	5
49	R:R:F43	R:R:N65	18.12	Yes	Yes	0	3	1
50	R:R:F43	R:R:P275	5.78	Yes	Yes	2	3	4
51	R:R:F43	R:R:L305	8.53	Yes	No	2	3	4
52	R:R:V45	R:R:V59	4.81	No	No	0	1	1
53	R:R:C61	R:R:V45	5.12	No	No	0	1	1
54	R:R:A46	R:R:E60	4.53	No	No	0	1	6
55	R:R:K48	R:R:Q50	2.71	No	No	9	1	3
56	R:R:E57	R:R:K48	2.7	No	No	9	2	1
57	R:R:D49	R:R:D51	2.66	No	No	0	1	5
58	R:R:E57	R:R:Q50	5.1	No	No	9	2	3
59	R:R:L52	R:R:P56	4.93	Yes	Yes	0	2	1
60	R:R:L52	S:S:L461	4.15	Yes	No	0	2	3
61	R:R:L52	S:S:K462	5.64	Yes	No	0	2	5
62	R:R:L52	S:S:R465	6.07	Yes	No	0	2	4
63	R:R:P56	R:R:R55	2.88	Yes	Yes	9	1	5
64	R:R:R55	S:S:E456	8.14	Yes	No	9	5	6
65	R:R:R55	S:S:W458	5	Yes	Yes	9	5	7
66	R:R:P56	S:S:Y162	9.74	Yes	No	0	1	6
67	R:R:P56	S:S:W458	12.16	Yes	Yes	9	1	7
68	R:R:C102	R:R:C61	7.28	No	No	2	2	1
69	R:R:E278	R:R:R63	6.98	No	No	0	1	5
70	R:R:F66	R:R:Y64	5.16	Yes	Yes	2	5	3
71	R:R:E351	R:R:Y64	11.22	No	Yes	2	6	3
72	R:R:F352	R:R:Y64	5.16	Yes	Yes	2	8	3
73	R:R:E355	R:R:Y64	16.83	No	Yes	2	4	3
74	R:R:N65	R:R:R67	3.62	Yes	No	0	1	4
75	R:R:G68	R:R:N65	3.39	No	Yes	0	6	1
76	R:R:F352	R:R:F66	4.29	Yes	Yes	2	8	5
77	R:R:F66	R:R:T406	12.97	Yes	No	2	5	4
78	R:R:F66	R:R:P407	5.78	Yes	No	2	5	4
79	R:R:R67	R:R:R70	4.26	No	No	0	4	5
80	R:R:R67	R:R:W71	9	No	Yes	0	4	4
81	R:R:G68	R:R:W71	5.63	No	Yes	0	6	4
82	R:R:F69	R:R:Q73	10.54	Yes	Yes	2	7	7
83	R:R:F69	R:R:V338	2.62	Yes	Yes	2	7	4
84	R:R:F69	R:R:N346	6.04	Yes	Yes	2	7	1
85	R:R:F352	R:R:F69	9.65	Yes	Yes	2	8	7
86	R:R:F69	R:R:Y408	8.25	Yes	Yes	2	7	5
87	R:R:F411	R:R:R70	12.83	No	No	0	5	5
88	R:R:T146	R:R:W71	3.64	Yes	Yes	2	3	4
89	R:R:W71	R:R:Y168	2.89	Yes	Yes	2	4	5
90	R:R:I416	R:R:W71	17.62	No	Yes	0	6	4
91	R:R:I76	R:R:L72	2.85	Yes	Yes	2	7	7
92	R:R:I98	R:R:L72	4.28	Yes	Yes	2	4	7
93	R:R:L72	R:R:N346	4.12	Yes	Yes	2	7	1
94	R:R:F334	R:R:Q73	7.03	Yes	Yes	2	6	7
95	R:R:L335	R:R:Q73	2.66	Yes	Yes	2	4	7
96	R:R:N346	R:R:Q73	3.96	Yes	Yes	2	1	7
97	R:R:Q73	R:R:Y408	5.64	Yes	Yes	2	7	5
98	R:R:A74	R:R:F331	4.16	No	Yes	0	7	4
99	R:R:I98	R:R:M75	7.29	Yes	Yes	2	4	5
100	R:R:M75	R:R:V420	3.04	Yes	No	2	5	8
101	R:R:M75	R:R:V424	3.04	Yes	No	0	5	7
102	R:R:I76	R:R:Y96	7.25	Yes	Yes	2	7	4
103	R:R:F334	R:R:I76	2.51	Yes	Yes	2	6	7
104	R:R:I76	R:R:N346	4.25	Yes	Yes	2	7	1
105	R:R:F77	R:R:I328	2.51	No	Yes	2	8	3
106	R:R:F331	R:R:F77	9.65	Yes	No	2	4	8
107	R:R:F334	R:R:F77	10.72	Yes	No	2	6	8
108	R:R:A78	R:R:Y421	2.67	No	Yes	0	7	8
109	R:R:A78	R:R:V424	5.09	No	No	0	7	7
110	R:R:I79	R:R:Y96	6.04	No	Yes	0	7	4
111	R:R:E81	R:R:Y421	7.86	No	Yes	2	9	8
112	R:R:E81	R:R:Y425	11.22	No	No	2	9	8
113	R:R:I82	R:R:L94	4.28	No	Yes	0	9	9
114	R:R:I82	R:R:Y425	12.09	No	No	0	9	8
115	R:R:A428	R:R:I82	4.87	No	No	0	6	9
116	R:R:N83	R:R:T93	4.39	No	No	0	4	9
117	R:R:L94	R:R:N83	5.49	Yes	No	0	9	4
118	R:R:P86	R:R:S85	3.56	No	No	0	2	3
119	R:R:N87	R:R:S85	4.47	No	No	0	6	3
120	R:R:L88	R:R:N87	4.12	Yes	No	0	9	6
121	R:R:L88	R:R:L89	2.77	Yes	No	0	9	8
122	R:R:H429	R:R:L88	9	No	Yes	0	8	9
123	R:R:L88	R:R:Q432	6.65	Yes	No	0	9	5
124	R:R:L431	R:R:L89	6.92	No	No	0	6	8
125	R:R:N91	R:R:P90	3.26	No	No	0	5	9
126	R:R:P90	R:R:Y435	9.74	No	No	0	9	3
127	R:R:I452	R:R:M92	10.2	No	No	0	1	7
128	R:R:G95	R:R:Y96	2.9	No	Yes	0	7	4
129	R:R:I98	R:R:Y96	8.46	Yes	Yes	2	4	4
130	R:R:N345	R:R:Y96	3.49	No	Yes	2	7	4
131	R:R:R97	R:R:S114	2.64	Yes	No	0	8	5
132	R:R:F115	R:R:R97	3.21	Yes	Yes	23	5	8
133	R:R:P137	R:R:R97	4.32	No	Yes	0	3	8
134	R:R:R97	R:R:T139	2.59	Yes	No	23	8	4
135	R:R:A111	R:R:F99	4.16	No	Yes	0	6	9
136	R:R:F99	R:R:S114	5.28	Yes	No	0	9	5
137	R:R:F115	R:R:F99	5.36	Yes	Yes	0	5	9
138	R:R:D100	R:R:T101	2.89	Yes	No	0	7	7
139	R:R:C102	R:R:D100	6.22	No	Yes	2	2	7
140	R:R:D100	R:R:F348	4.78	Yes	Yes	2	7	5
141	I:I:?1104	R:R:T101	8.12	No	No	0	0	7
142	R:R:S106	R:R:T104	6.4	No	No	0	3	4
143	R:R:K107	R:R:T104	3	No	No	0	7	4
144	R:R:L109	R:R:V105	2.98	No	No	0	4	3
145	R:R:V105	S:S:N156	2.96	No	Yes	4	3	5
146	R:R:V105	S:S:Q180	2.87	No	Yes	4	3	6
147	R:R:E110	R:R:K107	5.4	No	No	0	6	7
148	R:R:A111	R:R:E110	3.02	No	No	0	6	6
149	R:R:F115	R:R:T112	2.59	Yes	No	0	5	5
150	R:R:T112	R:R:V154	4.76	No	Yes	0	5	8
151	R:R:L157	R:R:T112	2.95	No	No	0	7	5
152	R:R:L113	R:R:L157	2.77	No	No	0	3	7
153	R:R:L113	S:S:L157	2.77	No	No	0	3	7
154	R:R:F115	R:R:T139	2.59	Yes	No	23	5	4
155	R:R:F115	R:R:V142	3.93	Yes	No	0	5	7
156	R:R:F161	R:R:V116	9.18	No	No	0	4	7
157	R:R:I136	R:R:Q118	6.86	No	No	0	4	3
158	R:R:F161	R:R:N119	13.29	No	No	0	4	2
159	R:R:I136	R:R:P137	5.08	No	No	0	4	3
160	R:R:I140	R:R:V460	3.07	No	No	0	7	6
161	R:R:A141	R:R:I427	4.87	No	No	0	7	9
162	R:R:L158	R:R:V142	5.96	Yes	No	0	5	7
163	R:R:G144	R:R:Y168	5.79	No	Yes	0	6	5
164	R:R:T146	R:R:Y168	6.24	Yes	Yes	2	3	5
165	R:R:A169	R:R:T146	3.36	No	Yes	2	7	3
166	I:I:?1104	R:R:T146	2.71	No	Yes	0	0	3
167	R:R:G147	R:R:V150	3.68	No	No	0	9	8
168	R:R:S148	R:R:S172	4.89	No	No	0	5	6
169	R:R:S148	R:R:Y219	5.09	No	Yes	0	5	8
170	R:R:D218	R:R:G149	3.35	Yes	No	0	7	4
171	I:I:?1104	R:R:V150	8.21	No	No	0	0	8
172	R:R:S151	R:R:S170	6.52	No	Yes	7	5	7
173	R:R:F184	R:R:S151	2.64	Yes	No	7	6	5
174	R:R:L175	R:R:T152	2.95	Yes	No	7	8	5
175	R:R:F181	R:R:T152	3.89	Yes	No	7	7	5
176	R:R:D218	R:R:T152	4.34	Yes	No	0	7	5
177	R:R:A153	S:S:N156	3.13	No	Yes	0	6	5
178	R:R:L158	R:R:V154	2.98	Yes	Yes	7	5	8
179	R:R:Q165	R:R:V154	7.16	Yes	Yes	7	7	8
180	R:R:A155	R:R:Q165	3.03	No	Yes	0	6	7
181	R:R:A155	R:R:F181	5.55	No	Yes	0	6	7
182	R:R:F181	R:R:N156	3.62	Yes	No	0	7	5
183	R:R:N156	S:S:V105	4.43	No	No	0	5	3
184	R:R:N156	S:S:A153	3.13	No	No	0	5	5
185	R:R:L157	S:S:L113	2.77	No	No	0	7	3
186	R:R:I163	R:R:L158	4.28	No	Yes	0	8	5
187	R:R:L158	R:R:Q165	5.32	Yes	Yes	7	5	7
188	R:R:G159	R:R:S183	3.71	No	No	0	5	8
189	R:R:F161	R:R:L160	7.31	No	No	0	4	7
190	R:R:L160	S:S:E110	2.65	No	No	0	7	6
191	R:R:K182	R:R:Y162	10.75	No	No	0	7	6
192	R:R:Y162	S:S:P56	8.34	No	Yes	0	6	1
193	R:R:I163	R:R:P164	3.39	No	Yes	0	8	7
194	R:R:A457	R:R:I163	3.25	No	No	0	4	8
195	R:R:P164	R:R:V460	3.53	Yes	No	0	7	6
196	R:R:L461	R:R:P164	3.28	No	Yes	0	3	7
197	R:R:L464	R:R:P164	3.28	No	Yes	0	6	7
198	R:R:F184	R:R:Q165	10.54	Yes	Yes	7	6	7
199	R:R:A423	R:R:V166	3.39	No	No	0	8	8
200	R:R:I427	R:R:V166	4.61	No	No	0	9	8
201	R:R:S167	R:R:S170	6.52	No	Yes	7	8	7
202	R:R:F184	R:R:S167	3.96	Yes	No	7	6	8
203	R:R:R186	R:R:S167	2.64	Yes	No	7	9	8
204	R:R:A169	R:R:Y168	2.67	No	Yes	2	7	5
205	R:R:V420	R:R:Y168	10.09	No	Yes	2	8	5
206	R:R:A169	W:W:W1108	3.89	No	Yes	2	7	0
207	R:R:L175	R:R:S170	3	Yes	Yes	7	8	7
208	R:R:F184	R:R:S170	3.96	Yes	Yes	7	6	7
209	R:R:I188	R:R:S171	3.1	Yes	No	0	8	7
210	R:R:D191	R:R:S171	10.31	No	No	2	3	7
211	R:R:S171	R:R:Y219	2.54	No	Yes	2	7	8
212	R:R:L175	R:R:S172	7.51	Yes	No	0	8	6
213	R:R:L174	R:R:R173	7.29	Yes	Yes	7	8	3
214	R:R:N190	R:R:R173	3.62	Yes	Yes	7	9	3
215	R:R:E192	R:R:R173	4.65	No	Yes	7	4	3
216	R:R:P222	R:R:R173	2.88	Yes	Yes	7	7	3
217	R:R:R173	S:S:D216	9.53	Yes	No	0	3	6
218	R:R:D218	R:R:L174	2.71	Yes	Yes	0	7	8
219	R:R:L174	R:R:P222	6.57	Yes	Yes	7	8	7
220	R:R:L174	S:S:R221	7.29	Yes	No	0	8	4
221	R:R:F181	R:R:L175	7.31	Yes	Yes	7	7	8
222	R:R:F184	R:R:L175	14.61	Yes	Yes	7	6	8
223	R:R:L175	R:R:R186	6.07	Yes	Yes	7	8	9
224	R:R:R186	R:R:S176	3.95	Yes	No	7	9	6
225	R:R:N190	R:R:S176	4.47	Yes	No	7	9	6
226	R:R:N177	R:R:N179	5.45	No	No	0	7	6
227	R:R:N177	R:R:Q180	5.28	No	No	0	7	5
228	R:R:F184	R:R:K178	3.72	Yes	No	0	6	3
229	R:R:N179	S:S:Y247	13.96	No	No	0	6	3
230	R:R:F181	R:R:Q180	8.2	Yes	No	0	7	5
231	R:R:Q180	S:S:V105	5.73	No	No	0	5	3
232	R:R:L461	R:R:S183	3	No	No	0	3	8
233	R:R:F184	R:R:R186	4.28	Yes	Yes	7	6	9
234	R:R:L185	R:R:L464	2.77	No	No	0	9	6
235	R:R:F479	R:R:L185	8.53	No	No	0	8	9
236	R:R:G483	R:R:L185	3.42	No	No	0	7	9
237	R:R:I188	R:R:R186	2.51	Yes	Yes	0	8	9
238	R:R:N190	R:R:R186	4.82	Yes	Yes	7	9	9
239	R:R:D484	R:R:R186	3.57	No	Yes	0	4	9
240	R:R:N419	R:R:T187	5.85	No	No	0	8	7
241	R:R:I188	R:R:P189	3.39	Yes	No	0	8	7
242	R:R:I188	R:R:L323	4.28	Yes	No	0	8	5
243	R:R:I188	R:R:N419	4.25	Yes	No	0	8	8
244	R:R:E192	R:R:N190	5.26	No	Yes	7	4	9
245	R:R:D191	R:R:Q194	6.53	No	Yes	0	3	6
246	R:R:D191	R:R:Y219	5.75	No	Yes	2	3	8
247	R:R:E192	R:R:K226	16.2	No	Yes	7	4	6
248	R:R:H193	R:R:V513	8.3	No	Yes	0	9	3
249	R:R:F271	R:R:Q194	3.51	Yes	Yes	0	5	6
250	R:R:E298	R:R:Q194	5.1	No	Yes	0	6	6
251	R:R:F321	R:R:Q194	7.03	Yes	Yes	0	5	6
252	R:R:A195	R:R:K226	3.21	No	Yes	0	4	6
253	R:R:D200	R:R:T196	2.89	No	No	0	7	8
254	R:R:A197	R:R:F321	4.16	No	Yes	0	7	5
255	R:R:A197	R:R:Y511	9.34	No	Yes	0	7	5
256	R:R:M198	R:R:V269	3.04	No	Yes	3	7	5
257	R:R:F271	R:R:M198	7.46	Yes	No	3	5	7
258	R:R:F321	R:R:M198	8.71	Yes	No	3	5	7
259	R:R:A199	R:R:R234	5.53	No	Yes	0	6	5
260	R:R:D200	R:R:R234	10.72	No	Yes	0	7	5
261	R:R:D200	R:R:Y511	4.6	No	Yes	0	7	5
262	R:R:F205	R:R:I201	2.51	Yes	Yes	3	3	6
263	R:R:F321	R:R:I201	5.02	Yes	Yes	3	5	6
264	R:R:I201	R:R:I491	4.42	Yes	No	3	6	5
265	R:R:I201	R:R:L521	4.28	Yes	No	3	6	1
266	R:R:I201	R:R:I523	4.42	Yes	Yes	3	6	5
267	R:R:I202	R:R:V210	6.14	Yes	No	0	4	8
268	R:R:F227	R:R:I202	2.51	Yes	Yes	0	3	4
269	R:R:I202	R:R:I236	5.89	Yes	No	0	4	9
270	R:R:I202	R:R:L295	2.85	Yes	No	0	4	7
271	R:R:E203	R:R:R234	9.3	No	Yes	0	5	5
272	R:R:F205	R:R:Y204	9.28	Yes	No	3	3	7
273	R:R:I523	R:R:Y204	7.25	Yes	No	3	5	7
274	R:R:E525	R:R:Y204	12.35	No	No	3	3	7
275	R:R:F205	R:R:W207	11.02	Yes	Yes	3	3	7
276	R:R:F205	R:R:I523	3.77	Yes	Yes	3	3	5
277	R:R:E525	R:R:F205	7	No	Yes	3	3	3
278	R:R:F205	R:R:I528	3.77	Yes	Yes	3	3	3
279	R:R:F205	R:R:W530	7.02	Yes	Yes	3	3	3
280	R:R:F205	R:R:V537	5.24	Yes	Yes	3	3	8
281	H:H:?3	R:R:R206	8.67	Yes	No	8	0	9
282	H:H:?4	R:R:R206	10.84	No	No	8	0	9
283	R:R:V267	R:R:W207	9.81	Yes	Yes	3	6	7
284	R:R:W207	R:R:W530	3.75	Yes	Yes	3	7	3
285	R:R:V537	R:R:W207	3.68	Yes	Yes	3	8	7
286	R:R:S540	R:R:W207	8.65	No	Yes	3	5	7
287	R:R:N208	R:R:N541	12.26	No	No	8	9	9
288	R:R:C561	R:R:N208	4.72	No	No	8	9	9
289	H:H:?3	R:R:N208	11.02	Yes	No	8	0	9
290	R:R:C237	R:R:W209	2.61	Yes	Yes	8	5	7
291	R:R:D239	R:R:W209	16.75	Yes	Yes	8	7	7
292	R:R:T264	R:R:W209	4.85	No	Yes	0	7	7
293	R:R:A265	R:R:W209	3.89	No	Yes	8	6	7
294	R:R:C542	R:R:W209	18.28	No	Yes	8	8	7
295	R:R:P559	R:R:W209	4.05	Yes	Yes	8	3	7
296	R:R:C562	R:R:W209	5.22	No	Yes	8	8	7
297	R:R:G211	R:R:V210	3.68	No	No	0	5	8
298	R:R:V210	R:R:V267	8.02	No	Yes	0	8	6
299	R:R:F240	R:R:G211	7.53	Yes	No	0	4	5
300	R:R:I224	R:R:T212	7.6	No	Yes	0	5	6
301	R:R:F227	R:R:T212	2.59	Yes	Yes	3	3	6
302	R:R:I238	R:R:T212	4.56	No	Yes	3	8	6
303	R:R:I213	R:R:I244	4.42	No	No	30	5	3
304	R:R:I213	R:R:I268	2.94	No	No	0	5	6
305	R:R:I213	R:R:L280	2.85	No	No	30	5	4
306	R:R:A214	R:R:I224	6.5	No	No	0	5	5
307	R:R:A215	R:R:S272	3.42	No	No	0	7	4
308	R:R:D216	R:R:R221	7.15	No	Yes	0	6	4
309	R:R:D216	R:R:L243	5.43	No	No	0	6	5
310	R:R:D216	S:S:R173	9.53	No	Yes	0	6	4
311	R:R:D218	R:R:R221	5.96	Yes	Yes	0	7	4
312	R:R:G220	R:R:Y219	2.9	No	Yes	0	5	8
313	R:R:S297	R:R:Y219	5.09	No	Yes	0	8	8
314	R:R:A299	R:R:Y219	4	No	Yes	2	7	8
315	R:R:Y219	W:W:W1108	3.86	Yes	Yes	2	8	0
316	R:R:P222	R:R:R221	2.88	Yes	Yes	0	7	4
317	R:R:R221	S:S:L174	8.5	Yes	Yes	0	4	8
318	R:R:F271	R:R:I224	3.77	Yes	No	0	5	5
319	R:R:E225	R:R:R228	4.65	No	No	0	4	4
320	R:R:E225	S:S:E225	3.81	No	No	0	4	3
321	R:R:E229	R:R:K226	4.05	No	Yes	7	6	6
322	R:R:E230	R:R:K226	10.8	Yes	Yes	7	6	6
323	R:R:A231	R:R:F227	4.16	No	Yes	0	3	3
324	R:R:F227	R:R:I238	2.51	Yes	No	3	3	8
325	R:R:F227	R:R:V269	7.87	Yes	Yes	3	3	5
326	R:R:I238	R:R:R228	2.51	No	No	0	8	4
327	R:R:R228	S:S:R228	10.66	No	No	0	4	4
328	R:R:E229	R:R:E230	5.07	No	Yes	7	6	6
329	R:R:E230	R:R:E233	7.61	Yes	No	0	6	3
330	R:R:E230	R:R:R234	6.98	Yes	Yes	0	6	5
331	R:R:A231	R:R:I236	4.87	No	No	0	3	9
332	R:R:E232	R:R:E233	2.54	No	No	0	4	3
333	R:R:I236	R:R:R234	2.51	No	Yes	0	9	5
334	I:I:?1102	R:R:D235	4.98	No	No	0	0	6
335	R:R:C237	R:R:P559	3.77	Yes	Yes	8	5	3
336	R:R:C237	R:R:C561	7.28	Yes	No	8	5	9
337	R:R:D239	R:R:F240	3.58	Yes	Yes	8	7	4
338	R:R:D239	R:R:S263	4.42	Yes	No	8	7	5
339	R:R:A265	R:R:D239	3.09	No	Yes	8	6	7
340	R:R:F240	R:R:V259	2.62	Yes	No	0	4	5
341	R:R:F240	R:R:I260	2.51	Yes	No	0	4	3
342	R:R:F240	R:R:S263	5.28	Yes	No	8	4	5
343	R:R:E242	R:R:V256	8.56	No	No	0	4	3
344	R:R:E242	R:R:V259	7.13	No	No	0	4	5
345	R:R:I244	R:R:L280	2.85	No	No	30	3	4
346	R:R:Q246	R:R:Y247	13.53	No	No	0	3	1
347	R:R:D276	R:R:Q246	13.05	No	No	0	4	3
348	R:R:Y247	S:S:N179	13.96	No	No	0	1	5
349	R:R:I253	R:R:S248	4.64	No	No	0	3	3
350	R:R:D249	R:R:E252	15.59	No	No	0	1	4
351	R:R:E250	R:R:Q254	12.74	No	No	31	1	2
352	R:R:E250	R:R:E283	5.07	No	Yes	31	1	3
353	R:R:E251	R:R:E252	7.61	No	No	0	3	4
354	R:R:E283	R:R:I253	4.1	Yes	No	0	3	3
355	R:R:E283	R:R:Q254	10.19	Yes	No	31	3	2
356	R:R:Q254	R:R:R287	11.68	No	Yes	0	2	6
357	R:R:I260	R:R:V256	3.07	No	No	0	3	3
358	R:R:E283	R:R:V257	2.85	Yes	No	0	3	3
359	R:R:R287	R:R:V257	5.23	Yes	No	0	6	3
360	R:R:E258	R:R:R287	10.47	No	Yes	0	2	6
361	R:R:I289	R:R:Q261	10.98	No	No	0	6	3
362	R:R:P538	R:R:R266	2.88	Yes	No	0	3	8
363	R:R:R266	R:R:S540	2.64	No	No	0	8	5
364	R:R:L295	R:R:V267	2.98	No	Yes	0	7	6
365	R:R:S540	R:R:V267	4.85	No	Yes	3	5	6
366	R:R:I268	R:R:K292	7.27	No	No	0	6	8
367	R:R:I268	R:R:W294	10.57	No	No	0	6	7
368	R:R:F271	R:R:V269	2.62	Yes	Yes	3	5	5
369	R:R:L295	R:R:V269	4.47	No	Yes	0	7	5
370	R:R:L277	R:R:V270	2.98	Yes	No	11	3	6
371	R:R:V270	R:R:W300	9.81	No	Yes	11	6	5
372	R:R:F271	R:R:S297	3.96	Yes	No	0	5	8
373	R:R:L277	R:R:S272	3	Yes	No	0	3	4
374	R:R:G274	R:R:S273	3.71	Yes	No	2	1	4
375	R:R:P275	R:R:S273	5.34	Yes	No	2	4	4
376	R:R:G274	R:R:P275	4.06	Yes	Yes	2	1	4
377	R:R:G274	R:R:S303	3.71	Yes	No	2	1	3
378	L:L:?1103	R:R:G274	3.14	Yes	Yes	2	0	1
379	R:R:L305	R:R:P275	4.93	No	Yes	2	4	4
380	L:L:?1103	R:R:P275	3.02	Yes	Yes	2	0	4
381	R:R:I281	R:R:L277	2.85	No	Yes	11	2	3
382	R:R:L277	R:R:W300	10.25	Yes	Yes	11	3	5
383	R:R:I306	R:R:L277	2.85	Yes	Yes	11	4	3
384	R:R:E278	R:R:K282	6.75	No	No	0	1	6
385	R:R:I284	R:R:L280	7.14	No	No	0	3	4
386	R:R:I281	R:R:I306	4.42	No	Yes	11	2	4
387	R:R:F311	R:R:I281	8.79	No	No	0	4	2
388	R:R:E283	R:R:R286	11.63	Yes	No	0	3	3
389	R:R:I284	R:R:I289	2.94	No	No	0	3	6
390	R:R:F311	R:R:V285	9.18	No	No	0	4	4
391	R:R:V285	R:R:V314	6.41	No	No	0	4	6
392	R:R:R286	R:R:R287	5.33	No	Yes	0	3	6
393	R:R:N288	R:R:T290	4.39	No	No	32	3	4
394	H:H:?9	R:R:N288	30.62	No	No	32	0	3
395	R:R:I289	R:R:K292	2.91	No	No	0	6	8
396	H:H:?9	R:R:T290	6.57	No	No	32	0	4
397	R:R:I293	R:R:S317	6.19	No	No	0	8	7
398	R:R:I293	R:R:W530	3.52	No	Yes	3	8	3
399	R:R:I293	R:R:P538	5.08	No	Yes	3	8	3
400	R:R:I315	R:R:W294	7.05	Yes	No	11	5	7
401	R:R:T318	R:R:W294	3.64	No	No	11	6	7
402	R:R:A296	R:R:W300	9.08	No	Yes	0	8	5
403	R:R:S297	R:R:W300	3.71	No	Yes	0	8	5
404	R:R:E298	R:R:L323	6.63	No	No	0	6	5
405	R:R:E298	W:W:W1108	5.45	No	Yes	0	6	0
406	R:R:A299	W:W:W1108	3.89	No	Yes	2	7	0
407	R:R:I306	R:R:W300	5.87	Yes	Yes	11	4	5
408	R:R:W300	R:R:W494	2.81	Yes	Yes	11	5	7
409	R:R:L305	R:R:S303	3	No	No	2	4	3
410	L:L:?1103	R:R:S303	5.51	Yes	No	2	0	3
411	R:R:P407	R:R:S304	3.56	No	No	0	4	1
412	R:R:I306	R:R:W494	3.52	Yes	Yes	11	4	7
413	R:R:A307	R:R:W494	5.19	No	Yes	11	3	7
414	R:R:A307	R:R:V503	3.39	No	No	11	3	3
415	R:R:A307	R:R:F505	2.77	No	No	11	3	5
416	R:R:M308	R:R:P309	3.35	No	No	33	3	4
417	R:R:E310	R:R:M308	9.47	No	No	33	3	3
418	R:R:E310	R:R:P309	4.72	No	No	33	3	4
419	R:R:E310	R:R:F311	3.5	No	No	0	3	4
420	R:R:F312	R:R:L496	8.53	No	No	0	3	3
421	R:R:F312	R:R:V503	5.24	No	No	0	3	3
422	R:R:I315	R:R:T318	3.04	Yes	No	11	5	6
423	R:R:I315	R:R:W494	3.52	Yes	Yes	11	5	7
424	R:R:T318	R:R:W494	21.83	No	Yes	11	6	7
425	R:R:I319	R:R:N493	2.83	No	Yes	3	8	6
426	R:R:I319	R:R:I528	2.94	No	Yes	3	8	3
427	R:R:I319	R:R:W530	3.52	No	Yes	3	8	3
428	R:R:F321	R:R:I491	5.02	Yes	No	3	5	5
429	R:R:A322	R:R:R415	5.53	No	No	0	5	4
430	R:R:A322	R:R:I492	3.25	No	No	0	5	9
431	R:R:H510	R:R:K324	7.86	Yes	No	0	6	5
432	R:R:A325	R:R:H413	4.39	No	No	0	4	7
433	R:R:G326	R:R:Y418	8.69	No	Yes	0	4	7
434	R:R:M473	R:R:Q327	2.72	Yes	No	0	6	6
435	R:R:F331	R:R:I328	6.28	Yes	Yes	2	4	3
436	R:R:I328	R:R:L414	2.85	Yes	Yes	2	3	6
437	R:R:I328	R:R:Y421	9.67	Yes	Yes	2	3	8
438	R:R:F331	R:R:F334	3.22	Yes	Yes	2	4	6
439	R:R:F331	R:R:L335	10.96	Yes	Yes	2	4	4
440	R:R:F331	R:R:L414	3.65	Yes	Yes	2	4	6
441	R:R:F411	R:R:R332	18.17	No	No	0	5	3
442	R:R:L335	R:R:Y408	7.03	Yes	Yes	2	4	5
443	R:R:L335	R:R:M409	4.24	Yes	Yes	2	4	6
444	R:R:M409	R:R:Q336	6.8	Yes	No	0	6	4
445	R:R:F352	R:R:V338	3.93	Yes	Yes	2	8	4
446	R:R:I401	R:R:V338	3.07	Yes	Yes	2	3	4
447	R:R:V338	R:R:Y408	6.31	Yes	Yes	2	4	5
448	R:R:H339	R:R:P340	13.73	No	No	0	7	4
449	R:R:H339	R:R:K341	6.55	No	No	0	7	3
450	R:R:H339	R:R:K342	3.93	No	No	0	7	4
451	R:R:P340	R:R:W353	22.97	No	Yes	0	4	7
452	R:R:A349	R:R:S343	3.42	No	No	0	3	4
453	R:R:F348	R:R:N346	3.62	Yes	Yes	2	5	1
454	R:R:A349	R:R:N346	3.13	No	Yes	0	3	1
455	R:R:E351	R:R:E355	2.54	No	No	2	6	4
456	R:R:F352	R:R:I401	2.51	Yes	Yes	2	8	3
457	R:R:F352	R:R:Y408	13.41	Yes	Yes	2	8	5
458	R:R:F357	R:R:W353	14.03	No	Yes	2	4	7
459	R:R:G397	R:R:W353	4.22	No	Yes	2	4	7
460	R:R:E399	R:R:W353	8.72	Yes	Yes	2	5	7
461	R:R:I401	R:R:W353	4.7	Yes	Yes	2	3	7
462	R:R:C359	R:R:E354	4.56	No	No	0	3	3
463	R:R:F357	R:R:T356	11.67	No	No	0	4	8
464	R:R:E399	R:R:F357	16.32	Yes	No	2	5	4
465	R:R:C359	R:R:C395	7.28	No	No	0	3	6
466	R:R:C395	R:R:E399	6.08	No	Yes	0	6	5
467	R:R:G397	R:R:T396	3.64	No	No	2	4	5
468	R:R:D398	R:R:T396	13.01	No	No	0	8	5
469	R:R:E399	R:R:T396	8.47	Yes	No	2	5	5
470	R:R:E399	R:R:G397	4.91	Yes	No	2	5	4
471	R:R:I401	R:R:N400	2.83	Yes	Yes	2	3	6
472	R:R:N400	R:R:T402	14.62	Yes	No	2	6	1
473	R:R:N400	R:R:S403	4.47	Yes	No	2	6	3
474	H:H:?10	R:R:N400	33.07	No	Yes	2	0	6
475	R:R:M409	R:R:T402	3.01	Yes	No	2	6	1
476	H:H:?10	R:R:T402	9.2	No	No	2	0	1
477	H:H:?10	R:R:S403	4.02	No	No	2	0	3
478	R:R:D410	R:R:E405	11.69	No	No	0	5	3
479	R:R:P407	R:R:T406	3.5	No	No	2	4	4
480	R:R:M409	R:R:Y408	5.99	Yes	Yes	2	6	5
481	R:R:F411	R:R:L414	8.53	No	Yes	0	5	6
482	R:R:H413	R:R:T412	12.32	No	No	0	7	6
483	R:R:H413	R:R:R415	10.16	No	No	0	7	4
484	R:R:L414	R:R:S417	7.51	Yes	No	0	6	7
485	R:R:L422	R:R:Y418	19.93	No	Yes	0	9	7
486	R:R:S471	R:R:Y418	3.82	No	Yes	34	3	7
487	R:R:M473	R:R:Y418	8.38	Yes	Yes	34	6	7
488	R:R:Y421	R:R:Y425	14.89	Yes	No	2	8	8
489	R:R:N472	R:R:Y421	3.49	No	Yes	0	3	8
490	R:R:F479	R:R:S426	3.96	No	No	0	8	6
491	R:R:F469	R:R:H429	22.63	No	No	0	4	8
492	R:R:A430	R:R:L464	3.15	No	No	0	8	6
493	R:R:Q432	R:R:Y435	5.64	No	No	0	5	3
494	R:R:Q432	R:R:T436	2.83	No	No	0	5	4
495	R:R:D433	R:R:H463	11.35	No	Yes	0	5	7
496	R:R:H463	R:R:I434	15.91	Yes	No	0	7	2
497	R:R:I452	R:R:Y435	4.84	No	No	0	1	3
498	R:R:C437	R:R:C449	7.28	No	No	0	3	2
499	R:R:K441	R:R:T438	4.5	No	No	0	3	2
500	R:R:C449	R:R:G442	3.92	No	No	0	2	3
501	R:R:H463	R:R:L443	7.71	Yes	No	0	7	3
502	R:R:H466	R:R:L443	6.43	No	No	0	7	3
503	R:R:A450	R:R:F444	4.16	No	Yes	14	3	1
504	R:R:F444	R:R:W458	4.01	Yes	Yes	14	1	7
505	R:R:F444	R:R:Q459	4.68	Yes	Yes	14	1	7
506	R:R:F444	R:R:H463	4.53	Yes	Yes	0	1	7
507	R:R:N446	R:R:T445	5.85	No	No	0	1	4
508	R:R:A450	R:R:Q459	6.06	No	Yes	14	3	7
509	R:R:D451	R:R:K454	5.53	No	No	0	3	3
510	R:R:Q459	R:R:V455	2.87	Yes	No	0	7	4
511	R:R:E456	R:R:W458	9.81	No	Yes	14	5	7
512	R:R:E456	R:R:Q459	3.82	No	Yes	14	5	7
513	R:R:E456	S:S:R55	11.63	No	No	14	5	5
514	R:R:Q459	R:R:W458	17.52	Yes	Yes	14	7	7
515	R:R:W458	S:S:R55	7	Yes	No	14	7	5
516	R:R:W458	S:S:P56	8.11	Yes	Yes	14	7	1
517	R:R:L461	S:S:L52	4.15	No	Yes	0	3	2
518	R:R:H466	R:R:K462	9.17	No	No	0	7	6
519	R:R:K462	S:S:L52	4.23	No	Yes	0	6	2
520	R:R:R465	S:S:L52	3.64	No	Yes	0	5	2
521	R:R:F469	R:R:L467	3.65	No	No	0	4	5
522	R:R:N468	R:R:Q476	3.96	No	No	35	8	6
523	R:R:D478	R:R:N468	5.39	No	No	0	9	8
524	H:H:?11	R:R:N468	25.72	No	No	35	0	8
525	R:R:F469	R:R:V477	9.18	No	No	0	4	3
526	R:R:Q476	R:R:T470	5.67	No	No	0	6	7
527	R:R:M473	R:R:S471	3.07	Yes	No	34	6	3
528	R:R:E475	R:R:S471	2.87	No	No	0	3	3
529	R:R:M473	R:R:N472	2.8	Yes	No	0	6	3
530	H:H:?11	R:R:Q476	14.25	No	No	35	0	6
531	R:R:F479	R:R:L485	3.65	No	No	0	8	3
532	R:R:D480	R:R:E481	16.89	No	No	36	3	7
533	R:R:D480	R:R:F482	4.78	No	No	36	3	7
534	R:R:E481	R:R:F482	12.83	No	No	36	7	7
535	R:R:D484	R:R:F482	3.58	No	No	0	4	7
536	R:R:H510	R:R:N488	3.83	Yes	Yes	3	6	8
537	R:R:N488	R:R:N512	12.26	Yes	Yes	3	8	3
538	R:R:N488	R:R:V513	4.43	Yes	Yes	3	8	3
539	R:R:N488	R:R:Y514	8.14	Yes	Yes	3	8	5
540	H:H:?1	R:R:N488	24.5	Yes	Yes	3	0	8
541	R:R:G509	R:R:I491	3.53	No	No	0	2	5
542	R:R:F505	R:R:I492	6.28	No	No	0	5	9
543	R:R:H495	R:R:N493	7.65	No	Yes	0	4	6
544	R:R:N493	R:R:V508	2.96	Yes	No	3	6	9
545	R:R:I528	R:R:N493	2.83	Yes	Yes	3	3	6
546	R:R:V503	R:R:W494	7.36	No	Yes	11	3	7
547	R:R:F505	R:R:W494	10.02	No	Yes	11	5	7
548	R:R:E506	R:R:H495	11.08	No	No	0	5	4
549	R:R:H495	R:R:L529	3.86	No	No	0	4	8
550	R:R:P498	R:R:S497	3.56	No	Yes	37	7	3
551	R:R:E499	R:R:S497	4.31	No	Yes	37	4	3
552	R:R:S497	R:R:V504	4.85	Yes	No	0	3	4
553	R:R:E499	R:R:P498	14.15	No	No	37	4	7
554	R:R:D500	R:R:S502	5.89	No	No	0	5	3
555	R:R:E506	R:R:K527	6.75	No	No	0	5	7
556	R:R:K527	R:R:V508	3.04	No	No	0	7	9
557	R:R:I528	R:R:V508	4.61	Yes	No	3	3	9
558	R:R:H510	R:R:N512	2.55	Yes	Yes	3	6	3
559	H:H:?1	R:R:H510	13.76	Yes	Yes	3	0	6
560	R:R:V513	R:R:Y511	2.52	Yes	Yes	3	3	5
561	R:R:R520	R:R:Y511	9.26	No	Yes	3	6	5
562	R:R:L521	R:R:Y511	3.52	No	Yes	3	1	5
563	R:R:N512	R:R:Y514	8.14	Yes	Yes	3	3	5
564	H:H:?1	R:R:N512	17.15	Yes	Yes	3	0	3
565	R:R:R520	R:R:V513	3.92	No	Yes	3	6	3
566	H:H:?1	R:R:Y514	13.59	Yes	Yes	3	0	5
567	R:R:E519	R:R:K516	9.45	No	No	0	3	1
568	R:R:K517	R:R:R520	4.95	No	No	0	4	6
569	R:R:I523	R:R:L521	8.56	Yes	No	3	5	1
570	R:R:N524	R:R:N526	12.26	No	No	0	3	3
571	R:R:K527	R:R:N524	9.79	No	No	0	7	3
572	R:R:I528	R:R:W530	12.92	Yes	Yes	3	3	3
573	R:R:V537	R:R:W530	3.68	Yes	Yes	3	8	3
574	R:R:P538	R:R:W530	13.51	Yes	Yes	3	3	3
575	R:R:F533	R:R:S531	10.57	No	No	0	4	2
576	R:R:F533	R:R:S534	2.64	No	No	0	4	4
577	R:R:E536	R:R:S534	10.06	No	No	0	4	4
578	R:R:P538	R:R:V537	3.53	Yes	Yes	3	3	8
579	R:R:F539	R:R:N541	6.04	No	No	8	9	9
580	R:R:F539	R:R:R544	18.17	No	No	0	9	5
581	H:H:?3	R:R:F539	4.35	Yes	No	8	0	9
582	H:H:?3	R:R:N541	25.72	Yes	No	8	0	9
583	R:R:C542	R:R:C562	7.28	No	No	8	8	8
584	R:R:F563	R:R:S543	10.57	No	No	0	7	3
585	R:R:D545	R:R:T577	5.78	No	No	0	9	7
586	R:R:D545	R:R:D578	15.97	No	No	0	9	6
587	R:R:C546	R:R:T550	6.76	No	No	38	1	6
588	R:R:C546	R:R:C565	7.28	No	No	38	1	4
589	R:R:L547	R:R:P548	6.57	No	No	0	4	9
590	R:R:P548	R:R:T577	3.5	No	No	0	9	7
591	R:R:C565	R:R:T550	10.14	No	No	38	4	6
592	R:R:R551	R:R:V566	6.54	Yes	No	0	7	3
593	R:R:C582	R:R:R551	4.18	Yes	Yes	0	1	7
594	R:R:R551	S:S:R551	15.99	Yes	No	0	7	8
595	R:R:F563	R:R:K552	17.37	No	Yes	0	7	6
596	R:R:D578	R:R:K552	9.68	No	Yes	0	6	6
597	R:R:K552	S:S:I554	2.91	Yes	No	0	6	5
598	R:R:K552	S:S:E556	9.45	Yes	No	0	6	7
599	R:R:I554	S:S:I554	4.42	No	No	0	5	5
600	R:R:E558	R:R:I555	5.47	No	No	0	5	6
601	R:R:E564	R:R:I555	4.1	No	No	0	9	6
602	R:R:E556	S:S:S580	5.75	No	No	0	7	4
603	R:R:G557	S:S:D235	5.03	No	No	40	5	7
604	I:I:?1105	R:R:G557	3.14	No	No	40	0	5
605	R:R:E558	R:R:P559	6.29	No	Yes	0	5	3
606	R:R:C562	R:R:P559	3.77	No	Yes	8	8	3
607	R:R:C568	R:R:S574	5.16	No	Yes	39	4	7
608	R:R:C568	R:R:C582	7.28	No	Yes	39	4	1
609	R:R:C568	R:R:H595	2.95	No	No	0	4	5
610	R:R:E572	R:R:P569	12.58	No	No	0	7	5
611	R:R:D570	R:R:H595	12.61	No	No	0	7	5
612	R:R:G571	R:R:W590	8.44	No	Yes	41	7	8
613	R:R:G571	R:R:S591	3.71	No	No	41	7	8
614	R:R:C582	R:R:E572	6.08	Yes	No	0	1	7
615	R:R:E572	R:R:K584	6.75	No	No	0	7	9
616	R:R:D575	R:R:Y573	3.45	No	No	0	3	8
617	R:R:D583	R:R:Y573	6.9	No	No	0	3	8
618	R:R:C598	R:R:Y573	6.72	No	No	0	4	8
619	R:R:C582	R:R:S574	3.44	Yes	Yes	39	1	7
620	R:R:D575	R:R:E576	9.09	No	No	0	3	6
621	R:R:S580	S:S:I554	3.1	No	No	0	4	5
622	R:R:S580	S:S:E556	5.75	No	No	0	4	7
623	R:R:C585	R:R:Y589	2.69	No	Yes	0	5	7
624	R:R:C585	R:R:C598	7.28	No	No	0	5	4
625	R:R:P586	R:R:Y589	5.56	No	Yes	0	4	7
626	R:R:D588	R:R:Y589	8.05	No	Yes	0	4	7
627	R:R:P600	R:R:Y589	6.95	No	Yes	0	8	7
628	R:R:S591	R:R:W590	3.71	No	Yes	41	8	8
629	R:R:K601	R:R:W590	4.64	No	Yes	0	3	8
630	R:R:H595	R:R:S591	2.79	No	No	0	5	8
631	R:R:N592	R:R:N594	2.72	Yes	No	24	1	5
632	R:R:N592	R:R:T596	5.85	Yes	Yes	24	1	1
633	R:R:N592	R:R:S597	4.47	Yes	No	24	1	9
634	R:R:I599	R:R:N592	2.83	No	Yes	0	3	1
635	R:R:N594	R:R:T596	2.92	No	Yes	24	5	1
636	R:R:S597	R:R:T596	4.8	No	Yes	24	9	1
637	R:R:I599	R:R:P600	5.08	No	No	0	3	8
638	R:R:I760	R:R:Q602	12.35	No	No	0	8	5
639	R:R:I603	R:R:I761	2.94	No	No	0	6	7
640	R:R:E604	R:R:I760	2.73	No	No	0	6	8
641	R:R:E604	R:R:F762	8.16	No	No	0	6	7
642	R:R:E671	R:R:F605	5.83	No	No	0	9	9
643	R:R:K831	R:R:L606	4.23	No	No	0	6	7
644	R:R:L606	R:R:S834	4.5	No	No	0	7	8
645	R:R:S607	R:R:T609	3.2	No	No	0	6	7
646	R:R:E610	R:R:S607	2.87	Yes	No	0	4	6
647	R:R:I669	R:R:W608	17.62	No	No	0	8	4
648	R:R:G670	R:R:W608	5.63	No	No	0	5	4
649	R:R:E610	R:R:P611	11	Yes	No	0	4	6
650	R:R:E610	R:R:F612	8.16	Yes	No	0	4	8
651	R:R:I839	R:R:L616	4.28	No	No	0	8	4
652	R:R:F619	R:R:L842	4.87	No	No	0	7	7
653	R:R:A620	R:R:S665	3.42	No	No	0	4	7
654	R:R:G623	R:R:L622	3.42	Yes	No	0	7	7
655	R:R:F662	R:R:G623	4.52	Yes	Yes	42	6	7
656	R:R:F846	R:R:G623	3.01	No	Yes	42	9	7
657	R:R:I624	R:R:T627	3.04	No	No	0	1	2
658	R:R:F662	R:R:I624	5.02	Yes	No	0	6	1
659	R:R:L659	R:R:T627	4.42	No	No	0	6	2
660	R:R:F629	R:R:V633	3.93	No	Yes	0	7	9
661	R:R:F853	R:R:V630	2.62	Yes	No	0	3	4
662	R:R:L631	R:R:T635	2.95	No	No	0	3	4
663	R:R:G632	R:R:T635	3.64	No	No	0	5	4
664	R:R:G632	R:R:K636	3.49	No	No	0	5	5
665	R:R:F634	R:R:V633	3.93	No	Yes	0	4	9
666	R:R:K636	R:R:V633	3.04	No	Yes	43	5	9
667	R:R:F637	R:R:V633	2.62	No	Yes	43	5	9
668	R:R:F637	R:R:K636	12.41	No	No	43	5	5
669	R:R:N639	R:R:R638	20.49	No	No	0	9	5
670	R:R:R638	R:R:R648	3.2	No	Yes	44	5	7
671	R:R:R638	R:R:Y652	5.14	No	No	44	5	5
672	R:R:P641	R:R:T640	3.5	No	No	0	7	8
673	R:R:I642	R:R:T640	9.12	No	No	0	9	8
674	R:R:P641	R:R:R648	2.88	No	Yes	0	7	7
675	R:R:I642	R:R:K644	2.91	No	No	0	9	9
676	R:R:I642	R:R:R866	13.78	No	Yes	0	9	9
677	R:R:F801	R:R:V643	5.24	No	No	0	9	8
678	R:R:R866	R:R:V643	7.85	Yes	No	0	9	8
679	R:R:K644	R:R:R648	14.85	No	Yes	0	9	7
680	R:R:E649	R:R:N647	7.89	No	No	0	8	7
681	R:R:R648	R:R:Y652	9.26	Yes	No	44	7	5
682	R:R:E649	R:R:L721	9.28	No	Yes	0	8	3
683	R:R:L650	R:R:L654	2.77	Yes	Yes	13	9	9
684	R:R:C694	R:R:L650	3.17	No	Yes	13	7	9
685	R:R:K698	R:R:L650	11.28	No	Yes	13	9	9
686	R:R:S651	R:R:Y652	3.82	No	No	0	7	5
687	R:R:C694	R:R:L654	9.52	No	Yes	13	7	9
688	R:R:I695	R:R:L654	4.28	No	Yes	0	9	9
689	R:R:K698	R:R:L654	4.23	No	Yes	13	9	9
690	R:R:F853	R:R:L654	3.65	Yes	Yes	0	3	9
691	R:R:F853	R:R:L655	3.65	Yes	No	0	3	4
692	R:R:F656	R:R:L659	3.65	No	No	0	8	6
693	R:R:L690	R:R:S657	3	No	No	0	7	9
694	R:R:C691	R:R:S657	6.89	Yes	No	0	7	9
695	R:R:C691	R:R:L658	6.35	Yes	No	0	7	4
696	R:R:L658	R:R:L849	4.15	No	No	0	4	1
697	R:R:C660	R:R:S687	6.89	No	No	0	7	9
698	R:R:C661	R:R:S687	6.89	No	No	0	9	9
699	R:R:C661	R:R:F688	2.79	No	Yes	0	9	7
700	R:R:F662	R:R:S845	6.61	Yes	No	0	6	6
701	R:R:F662	R:R:F846	7.5	Yes	No	42	6	9
702	R:R:F684	R:R:S664	2.64	Yes	No	0	7	7
703	R:R:F667	R:R:L679	3.65	Yes	No	0	9	8
704	R:R:F667	R:R:R680	3.21	Yes	Yes	0	9	9
705	R:R:A683	R:R:F667	2.77	No	Yes	0	8	9
706	R:R:F668	R:R:R680	23.52	No	Yes	0	8	9
707	R:R:F668	R:R:V838	6.55	No	No	0	8	8
708	R:R:Q673	R:R:W675	9.86	No	No	0	3	5
709	R:R:Q673	R:R:T676	9.92	No	No	0	3	9
710	R:R:N674	R:R:R678	10.85	No	Yes	0	5	6
711	R:R:N674	R:R:S750	7.45	No	No	0	5	4
712	R:R:R678	R:R:W675	7	Yes	No	0	6	5
713	R:R:C677	R:R:R680	11.14	No	Yes	15	6	9
714	R:R:C677	R:R:P748	3.77	No	No	0	6	4
715	R:R:C677	R:R:C765	7.28	No	No	15	6	7
716	R:R:P747	R:R:R678	4.32	No	Yes	0	9	6
717	R:R:P748	R:R:R678	5.76	No	Yes	0	4	6
718	R:R:Q681	R:R:R680	16.35	Yes	Yes	15	5	9
719	R:R:C765	R:R:R680	4.18	No	Yes	15	7	9
720	R:R:Q681	R:R:W742	4.38	Yes	Yes	15	5	7
721	R:R:E767	R:R:Q681	6.37	Yes	Yes	15	8	5
722	R:R:L773	R:R:Q681	2.66	No	Yes	15	6	5
723	R:R:E837	R:R:Q681	6.37	No	Yes	0	6	5
724	R:R:F684	R:R:G685	3.01	Yes	No	0	7	7
725	R:R:F684	R:R:F688	5.36	Yes	Yes	0	7	7
726	R:R:F684	R:R:I841	16.33	Yes	No	0	7	8
727	R:R:F688	R:R:I692	12.56	Yes	No	0	7	9
728	R:R:F688	R:R:T780	3.89	Yes	No	0	7	6
729	R:R:F688	R:R:F814	6.43	Yes	Yes	0	7	7
730	R:R:Q735	R:R:V689	4.3	Yes	No	0	4	7
731	R:R:T780	R:R:V689	3.17	No	No	0	6	7
732	R:R:L690	R:R:T732	4.42	No	No	0	7	4
733	R:R:A784	R:R:I692	3.25	No	No	0	4	9
734	R:R:S693	R:R:V728	8.08	No	No	0	7	3
735	R:R:C787	R:R:L696	6.35	No	No	0	8	7
736	R:R:R701	R:R:V697	2.62	Yes	No	0	9	9
737	R:R:K698	R:R:K856	2.87	No	No	13	9	8
738	R:R:L704	R:R:R701	12.15	No	Yes	46	9	9
739	R:R:Q724	R:R:R701	5.84	No	Yes	46	6	9
740	R:R:L704	R:R:L723	2.77	No	No	0	9	8
741	R:R:L704	R:R:Q724	5.32	No	No	46	9	6
742	R:R:L721	R:R:N722	4.12	Yes	No	0	3	6
743	R:R:F725	R:R:L721	10.96	No	Yes	0	3	3
744	R:R:L726	R:R:L727	4.15	No	No	0	6	7
745	R:R:V734	R:R:Y779	10.09	No	No	0	9	7
746	R:R:I738	R:R:Q735	2.74	No	Yes	0	6	4
747	R:R:L776	R:R:Q735	11.98	No	Yes	0	8	4
748	R:R:Q735	R:R:Y779	14.65	Yes	No	0	4	7
749	R:R:I738	R:R:I741	2.94	No	No	0	6	9
750	R:R:V740	R:R:Y744	2.52	No	No	0	3	4
751	R:R:I741	R:R:T745	6.08	No	No	0	9	5
752	R:R:E767	R:R:W742	17.45	Yes	Yes	15	8	7
753	R:R:S769	R:R:W742	4.94	No	Yes	0	4	7
754	R:R:A772	R:R:W742	5.19	No	Yes	0	8	7
755	R:R:L773	R:R:W742	4.56	No	Yes	15	6	7
756	R:R:E767	R:R:P748	4.72	Yes	No	0	8	4
757	R:R:H766	R:R:S749	2.79	No	No	0	7	6
758	R:R:N753	R:R:Y751	3.49	No	No	0	4	3
759	R:R:H766	R:R:Y751	3.27	No	No	0	7	3
760	R:R:I761	R:R:R752	2.51	No	No	0	7	7
761	R:R:I763	R:R:R752	8.77	No	No	0	6	7
762	R:R:E755	R:R:N753	9.2	No	No	0	5	4
763	R:R:L756	R:R:N753	5.49	No	No	0	4	4
764	R:R:E755	R:R:H754	24.62	No	No	0	5	3
765	R:R:H754	R:R:I761	2.65	No	No	0	3	7
766	R:R:L756	R:R:Y829	3.52	No	No	0	4	8
767	R:R:E757	R:R:E759	5.07	No	No	0	4	6
768	R:R:D758	R:R:E759	3.9	No	No	0	5	6
769	R:R:E767	R:R:G768	3.27	Yes	No	0	8	9
770	R:R:E767	R:R:L773	9.28	Yes	No	15	8	6
771	R:R:F775	R:R:M771	6.22	No	No	0	7	7
772	R:R:G774	R:R:I777	3.53	No	No	0	4	6
773	R:R:I777	R:R:L776	2.85	No	No	0	6	8
774	R:R:I777	R:R:W818	7.05	No	No	0	6	5
775	R:R:L783	R:R:Y779	14.07	No	No	0	8	7
776	R:R:C781	R:R:F814	2.79	No	Yes	0	5	7
777	R:R:A784	R:R:F814	4.16	No	Yes	45	4	7
778	R:R:A784	R:R:F815	2.77	No	No	45	4	9
779	R:R:A785	R:R:F815	4.16	No	No	0	4	9
780	R:R:F790	R:R:I786	2.51	No	No	0	9	8
781	R:R:C787	R:R:M811	6.48	No	No	0	8	8
782	R:R:F789	R:R:F790	13.93	No	No	47	7	9
783	R:R:F789	R:R:K793	18.61	No	No	47	7	8
784	R:R:F790	R:R:K793	11.17	No	No	47	9	8
785	R:R:A791	R:R:I807	3.25	No	No	0	8	9
786	R:R:F792	R:R:R795	36.34	No	No	48	7	8
787	R:R:F792	R:R:K796	4.96	No	No	48	7	9
788	R:R:F792	R:R:T808	5.19	No	No	0	7	9
789	R:R:K796	R:R:R795	16.09	No	No	48	9	8
790	R:R:K805	R:R:R795	18.56	No	No	0	5	8
791	R:R:E799	R:R:P798	3.14	No	No	0	8	8
792	R:R:N802	R:R:P798	3.26	No	No	0	9	8
793	R:R:F801	R:R:I859	2.51	No	No	0	9	9
794	R:R:K805	R:R:N802	5.6	No	No	0	5	9
795	R:R:E803	R:R:F806	13.99	Yes	No	13	9	9
796	R:R:E803	R:R:N855	9.2	Yes	No	13	9	9
797	R:R:E803	R:R:K856	10.8	Yes	No	13	9	8
798	R:R:F806	R:R:N855	22.96	No	No	13	9	9
799	R:R:I807	R:R:M811	4.37	No	No	0	9	8
800	R:R:F809	R:R:I813	5.02	No	Yes	16	9	9
801	R:R:C851	R:R:F809	4.19	No	No	16	9	9
802	R:R:L848	R:R:S810	3	No	No	16	8	9
803	R:R:C851	R:R:S810	3.44	No	No	16	9	9
804	R:R:I852	R:R:S810	6.19	No	No	16	9	9
805	R:R:C851	R:R:I813	3.27	No	Yes	16	9	9
806	R:R:F814	R:R:F815	13.93	Yes	No	45	7	9
807	R:R:A844	R:R:V817	3.39	No	No	0	8	9
808	R:R:I819	R:R:W818	3.52	No	No	0	7	5
809	R:R:I822	R:R:W818	3.52	No	No	0	9	5
810	R:R:F821	R:R:Y825	11.35	Yes	No	0	8	6
811	R:R:F821	R:R:V836	7.87	Yes	No	0	8	9
812	R:R:E837	R:R:F821	4.66	No	Yes	0	6	8
813	R:R:A840	R:R:F821	5.55	No	Yes	0	9	8
814	R:R:I822	R:R:P823	3.39	No	No	0	9	8
815	R:R:V833	R:R:Y825	3.79	No	No	0	8	6
816	R:R:F832	R:R:T828	3.89	No	No	0	7	6
817	R:R:T828	R:R:V833	7.93	No	No	0	6	8
818	R:R:F832	R:R:K831	14.89	No	No	0	7	6
819	R:R:I852	R:R:L848	2.85	No	No	16	9	8
820	R:R:F853	R:R:I852	5.02	Yes	No	0	3	9
821	R:R:K856	R:R:N855	5.6	No	No	13	8	9
822	R:R:I859	R:R:Y858	3.63	No	No	0	9	8
823	R:R:F862	R:R:Y858	19.6	No	No	0	6	8
824	R:R:I859	R:R:K863	2.91	No	No	0	9	8
825	R:R:I860	R:R:R866	15.03	No	Yes	0	6	9
826	R:R:K863	R:R:S865	6.12	No	No	0	8	6
827	R:R:P864	R:R:R866	4.32	No	Yes	0	6	9
828	R:R:N867	R:R:T868	2.92	No	No	0	7	5
829	S:S:F99	S:S:P23	8.67	Yes	No	0	9	3
830	S:S:E110	S:S:P23	3.14	No	No	0	6	3
831	S:S:Q28	S:S:R26	10.51	No	No	0	4	5
832	S:S:F99	S:S:R26	6.41	Yes	No	0	9	5
833	S:S:A27	S:S:I98	3.25	No	Yes	0	3	4
834	S:S:A27	S:S:F348	2.77	No	Yes	0	3	5
835	S:S:K29	S:S:Y96	15.53	No	Yes	1	2	4
836	S:S:K29	S:S:N345	13.99	No	No	1	2	7
837	S:S:G31	S:S:T93	3.64	No	No	0	8	9
838	S:S:D32	S:S:M92	4.16	No	No	0	6	7
839	S:S:D32	S:S:T93	8.67	No	No	0	6	9
840	S:S:I33	S:S:L94	2.85	No	No	0	4	9
841	S:S:I140	S:S:I33	5.89	No	No	12	7	4
842	S:S:I33	S:S:L431	2.85	No	Yes	12	4	7
843	S:S:I34	S:S:R97	2.51	No	No	0	6	8
844	S:S:L35	S:S:L94	5.54	No	No	0	9	9
845	S:S:I427	S:S:L35	2.85	No	No	0	9	9
846	S:S:F115	S:S:G36	4.52	Yes	No	4	5	6
847	S:S:G36	S:S:V142	3.68	No	Yes	4	6	8
848	S:S:L38	S:S:T101	5.9	No	Yes	0	7	7
849	S:S:L38	S:S:V154	2.98	No	Yes	0	7	8
850	S:S:F39	S:S:L72	3.65	Yes	Yes	1	5	7
851	S:S:F39	S:S:M75	6.22	Yes	Yes	1	5	5
852	S:S:F39	S:S:I98	3.77	Yes	Yes	1	5	4
853	S:S:F39	S:S:Y168	11.35	Yes	Yes	1	5	5
854	S:S:F39	S:S:V420	3.93	Yes	No	1	5	8
855	S:S:N65	S:S:P40	3.26	No	Yes	0	1	4
856	S:S:P40	S:S:T101	3.5	Yes	Yes	1	4	7
857	S:S:P40	S:S:T146	10.49	Yes	Yes	1	4	4
858	I:I:?1106	S:S:P40	6.03	Yes	Yes	1	0	4
859	S:S:H42	S:S:I41	3.98	Yes	Yes	1	2	7
860	S:S:I41	S:S:Y64	3.63	Yes	Yes	1	7	3
861	S:S:I41	S:S:L72	2.85	Yes	Yes	1	7	7
862	S:S:D100	S:S:I41	12.59	Yes	Yes	1	7	7
863	S:S:F348	S:S:I41	7.54	Yes	Yes	1	5	7
864	S:S:C61	S:S:H42	8.85	No	Yes	1	1	2
865	S:S:H42	S:S:Y64	4.36	Yes	Yes	1	2	3
866	S:S:D100	S:S:H42	5.04	Yes	Yes	1	7	2
867	S:S:C102	S:S:H42	5.9	No	Yes	1	2	2
868	S:S:E351	S:S:H42	11.08	No	Yes	1	6	2
869	S:S:F43	S:S:R63	6.41	Yes	Yes	1	3	5
870	S:S:F43	S:S:N65	20.54	Yes	No	0	3	1
871	S:S:F43	S:S:P275	2.89	Yes	Yes	1	3	5
872	S:S:F43	S:S:L305	10.96	Yes	Yes	1	3	4
873	S:S:V45	S:S:V59	6.41	No	No	0	1	1
874	S:S:T104	S:S:V45	6.35	No	No	0	4	1
875	S:S:A46	S:S:E60	4.53	No	No	0	1	6
876	S:S:K48	S:S:Q50	8.14	No	No	0	1	3
877	S:S:D51	S:S:K53	12.44	No	No	0	5	2
878	S:S:L52	S:S:P56	3.28	Yes	Yes	0	2	1
879	S:S:P56	S:S:R55	2.88	Yes	No	14	1	5
880	S:S:K107	S:S:V59	3.04	No	No	0	7	1
881	S:S:C102	S:S:C61	7.28	No	No	1	2	1
882	S:S:I62	S:S:R63	6.26	No	Yes	0	2	5
883	S:S:E278	S:S:R63	9.3	No	Yes	1	1	5
884	S:S:L305	S:S:R63	4.86	Yes	Yes	1	4	5
885	S:S:F66	S:S:Y64	6.19	Yes	Yes	1	5	3
886	S:S:E351	S:S:Y64	8.98	No	Yes	1	6	3
887	S:S:F352	S:S:Y64	6.19	Yes	Yes	1	8	3
888	S:S:E355	S:S:Y64	11.22	No	Yes	0	4	3
889	S:S:G68	S:S:N65	3.39	No	No	0	6	1
890	S:S:F352	S:S:F66	4.29	Yes	Yes	1	8	5
891	S:S:F66	S:S:T356	3.89	Yes	No	1	5	8
892	S:S:F66	S:S:T406	9.08	Yes	No	1	5	3
893	S:S:F66	S:S:P407	10.11	Yes	No	1	5	4
894	S:S:R67	S:S:R70	5.33	Yes	No	0	4	5
895	S:S:R67	S:S:W71	7	Yes	Yes	1	4	4
896	S:S:R67	S:S:S302	3.95	Yes	No	0	4	5
897	S:S:R67	X:X:W1108	3	Yes	Yes	1	4	0
898	S:S:G68	S:S:W71	5.63	No	Yes	0	6	4
899	S:S:F69	S:S:Q73	4.68	Yes	Yes	1	7	7
900	S:S:F69	S:S:V338	2.62	Yes	Yes	1	7	4
901	S:S:F69	S:S:N346	3.62	Yes	Yes	1	7	2
902	S:S:F352	S:S:F69	13.93	Yes	Yes	1	8	7
903	S:S:F69	S:S:Y408	7.22	Yes	Yes	1	7	5
904	S:S:F411	S:S:R70	9.62	No	No	0	4	5
905	S:S:R70	S:S:S417	6.59	No	Yes	0	5	7
906	S:S:T146	S:S:W71	3.64	Yes	Yes	1	4	4
907	S:S:I416	S:S:W71	14.09	No	Yes	0	6	4
908	S:S:S417	S:S:W71	4.94	Yes	Yes	1	7	4
909	S:S:W71	X:X:W1108	2.81	Yes	Yes	1	4	0
910	S:S:I76	S:S:L72	2.85	Yes	Yes	1	7	7
911	S:S:I98	S:S:L72	4.28	Yes	Yes	1	4	7
912	S:S:L72	S:S:N346	2.75	Yes	Yes	1	7	2
913	S:S:F348	S:S:L72	3.65	Yes	Yes	1	5	7
914	S:S:I76	S:S:Q73	2.74	Yes	Yes	1	7	7
915	S:S:F334	S:S:Q73	9.37	No	Yes	0	6	7
916	S:S:L335	S:S:Q73	3.99	No	Yes	1	4	7
917	S:S:Q73	S:S:V338	2.87	Yes	Yes	1	7	4
918	S:S:N346	S:S:Q73	2.64	Yes	Yes	1	2	7
919	S:S:Q73	S:S:Y408	4.51	Yes	Yes	1	7	5
920	S:S:A74	S:S:F331	4.16	No	Yes	1	7	4
921	S:S:A74	S:S:S417	3.42	No	Yes	1	7	7
922	S:S:I79	S:S:M75	2.92	No	Yes	0	7	5
923	S:S:I98	S:S:M75	5.83	Yes	Yes	1	4	5
924	S:S:M75	S:S:V143	7.61	Yes	No	0	5	8
925	S:S:M75	S:S:V424	3.04	Yes	No	0	5	7
926	S:S:I76	S:S:Y96	8.46	Yes	Yes	1	7	4
927	S:S:I76	S:S:N346	4.25	Yes	Yes	1	7	2
928	S:S:E80	S:S:F77	4.66	No	Yes	1	8	8
929	S:S:E81	S:S:F77	3.5	Yes	Yes	1	9	8
930	S:S:F77	S:S:I328	2.51	Yes	Yes	1	8	4
931	S:S:F331	S:S:F77	9.65	Yes	Yes	1	4	8
932	S:S:F334	S:S:F77	12.86	No	Yes	0	6	8
933	S:S:A78	S:S:Y421	2.67	No	Yes	0	7	8
934	S:S:A78	S:S:V424	5.09	No	No	0	7	7
935	S:S:I79	S:S:Y96	8.46	No	Yes	0	7	4
936	S:S:E80	S:S:E81	2.54	No	Yes	1	8	9
937	S:S:E80	S:S:N84	3.94	No	No	0	8	6
938	S:S:E81	S:S:Y421	7.86	Yes	Yes	1	9	8
939	S:S:E81	S:S:Y425	11.22	Yes	No	1	9	7
940	S:S:I82	S:S:Y425	9.67	No	No	0	9	7
941	S:S:A428	S:S:I82	4.87	No	No	0	6	9
942	S:S:N83	S:S:T93	5.85	No	No	0	4	9
943	S:S:L94	S:S:N83	5.49	No	No	0	9	4
944	S:S:P86	S:S:S85	3.56	No	No	12	2	3
945	S:S:N87	S:S:S85	5.96	No	No	12	6	3
946	S:S:L88	S:S:S85	3	Yes	No	12	9	3
947	S:S:N87	S:S:P86	3.26	No	No	12	6	2
948	S:S:L88	S:S:L89	2.77	Yes	Yes	12	9	8
949	S:S:H429	S:S:L88	5.14	No	Yes	0	8	9
950	S:S:L88	S:S:Q432	7.99	Yes	Yes	12	9	4
951	S:S:L89	S:S:M92	5.65	Yes	No	0	8	7
952	S:S:L431	S:S:L89	2.77	Yes	Yes	12	7	8
953	S:S:L89	S:S:Q432	3.99	Yes	Yes	12	8	4
954	S:S:N91	S:S:P90	3.26	No	No	0	5	9
955	S:S:P90	S:S:Y435	11.13	No	No	0	9	3
956	S:S:I452	S:S:M92	4.37	Yes	No	0	1	7
957	S:S:G95	S:S:Y96	2.9	No	Yes	0	7	4
958	S:S:I98	S:S:Y96	6.04	Yes	Yes	1	4	4
959	S:S:N345	S:S:Y96	3.49	No	Yes	1	7	4
960	S:S:F99	S:S:R97	5.34	Yes	No	4	9	8
961	S:S:R97	S:S:S114	5.27	No	No	4	8	5
962	S:S:A111	S:S:F99	5.55	No	Yes	0	6	9
963	S:S:F99	S:S:S114	5.28	Yes	No	4	9	5
964	S:S:F115	S:S:F99	6.43	Yes	Yes	4	5	9
965	S:S:D100	S:S:T101	2.89	Yes	Yes	1	7	7
966	S:S:C102	S:S:D100	6.22	No	Yes	1	2	7
967	S:S:A108	S:S:T101	3.36	No	Yes	0	6	7
968	I:I:?1106	S:S:T101	8.12	Yes	Yes	1	0	7
969	S:S:K107	S:S:T104	3	No	No	0	7	4
970	S:S:L109	S:S:V105	2.98	No	No	0	4	3
971	S:S:E110	S:S:K107	5.4	No	No	0	6	7
972	S:S:T112	S:S:V154	4.76	No	Yes	4	5	8
973	S:S:L157	S:S:T112	5.9	No	No	0	7	5
974	S:S:L158	S:S:T112	2.95	Yes	No	4	5	5
975	S:S:L113	S:S:L157	2.77	No	No	0	3	7
976	S:S:F115	S:S:T139	6.49	Yes	No	0	5	4
977	S:S:F115	S:S:V142	6.55	Yes	Yes	4	5	8
978	S:S:F161	S:S:V116	6.55	Yes	No	0	4	7
979	S:S:Q118	S:S:S138	2.89	No	No	0	3	7
980	S:S:F161	S:S:N119	10.87	Yes	No	0	4	2
981	S:S:D122	S:S:I121	4.2	No	No	0	3	1
982	S:S:A141	S:S:I140	3.25	No	No	0	7	7
983	S:S:I140	S:S:L431	4.28	No	Yes	12	7	7
984	S:S:A141	S:S:P164	5.61	No	Yes	0	7	8
985	S:S:A141	S:S:I427	3.25	No	No	0	7	9
986	S:S:L158	S:S:V142	4.47	Yes	Yes	4	5	8
987	S:S:Q165	S:S:V142	2.87	Yes	Yes	4	6	8
988	S:S:G144	S:S:Y168	5.79	No	Yes	0	6	5
989	S:S:A145	S:S:V150	3.39	No	No	0	5	9
990	S:S:A145	S:S:S151	3.42	No	Yes	0	5	4
991	S:S:T146	S:S:Y168	12.48	Yes	Yes	1	4	5
992	I:I:?1106	S:S:T146	5.41	Yes	Yes	1	0	4
993	S:S:S148	S:S:S172	4.89	No	No	0	5	4
994	S:S:S148	S:S:Y219	5.09	No	Yes	0	5	8
995	I:I:?1106	S:S:V150	8.21	Yes	No	0	0	9
996	S:S:S151	S:S:S170	6.52	Yes	No	4	4	7
997	S:S:L175	S:S:S151	4.5	Yes	Yes	4	7	4
998	S:S:F184	S:S:S151	2.64	Yes	Yes	4	7	4
999	S:S:L175	S:S:T152	2.95	Yes	No	4	7	5
1000	S:S:F181	S:S:T152	5.19	Yes	No	4	6	5
1001	S:S:D218	S:S:T152	2.89	Yes	No	0	6	5
1002	S:S:L158	S:S:V154	2.98	Yes	Yes	4	5	8
1003	S:S:Q165	S:S:V154	7.16	Yes	Yes	4	6	8
1004	S:S:A155	S:S:Q165	3.03	No	Yes	0	5	6
1005	S:S:A155	S:S:F181	4.16	No	Yes	0	5	6
1006	S:S:N156	S:S:Q180	3.96	Yes	Yes	4	5	6
1007	S:S:F181	S:S:N156	6.04	Yes	Yes	4	6	5
1008	S:S:L158	S:S:Q165	3.99	Yes	Yes	4	5	6
1009	S:S:F161	S:S:L160	7.31	Yes	No	0	4	7
1010	S:S:F161	S:S:I163	2.51	Yes	No	0	4	9
1011	S:S:K182	S:S:Y162	9.55	No	No	0	7	6
1012	S:S:I163	S:S:P164	3.39	No	Yes	0	9	8
1013	S:S:A457	S:S:I163	3.25	No	No	0	5	9
1014	S:S:L461	S:S:P164	3.28	No	Yes	0	3	8
1015	S:S:L464	S:S:P164	3.28	Yes	Yes	0	6	8
1016	S:S:F184	S:S:Q165	10.54	Yes	Yes	4	7	6
1017	S:S:A423	S:S:V166	3.39	No	No	0	9	8
1018	S:S:I427	S:S:V166	3.07	No	No	0	9	8
1019	S:S:S167	S:S:S170	6.52	No	No	0	7	7
1020	S:S:F184	S:S:S167	3.96	Yes	No	0	7	7
1021	S:S:A169	S:S:Y168	2.67	No	Yes	0	7	5
1022	S:S:V420	S:S:Y168	10.09	No	Yes	1	8	5
1023	S:S:A169	X:X:W1108	5.19	No	Yes	0	7	0
1024	S:S:I188	S:S:S171	3.1	Yes	No	0	8	6
1025	S:S:D191	S:S:S171	4.42	No	No	0	1	6
1026	S:S:S171	S:S:Y219	2.54	No	Yes	0	6	8
1027	S:S:L174	S:S:S172	4.5	Yes	No	0	8	4
1028	S:S:L174	S:S:R173	6.07	Yes	Yes	10	8	4
1029	S:S:N190	S:S:R173	3.62	No	Yes	10	8	4
1030	S:S:E192	S:S:R173	4.65	No	Yes	10	4	4
1031	S:S:P222	S:S:R173	2.88	No	Yes	10	7	4
1032	S:S:D218	S:S:L174	2.71	Yes	Yes	0	6	8
1033	S:S:L174	S:S:P222	4.93	Yes	No	10	8	7
1034	S:S:F181	S:S:L175	7.31	Yes	Yes	4	6	7
1035	S:S:F184	S:S:L175	14.61	Yes	Yes	4	7	7
1036	S:S:L175	S:S:R186	4.86	Yes	Yes	4	7	8
1037	S:S:R186	S:S:S176	5.27	Yes	No	0	8	7
1038	S:S:N177	S:S:N179	5.45	No	No	0	7	5
1039	S:S:N177	S:S:Q180	5.28	No	Yes	0	7	6
1040	S:S:F181	S:S:Q180	5.86	Yes	Yes	4	6	6
1041	S:S:L461	S:S:S183	4.5	No	No	0	3	7
1042	S:S:F184	S:S:R186	6.41	Yes	Yes	4	7	8
1043	S:S:L185	S:S:L464	5.54	No	Yes	0	8	6
1044	S:S:I188	S:S:R186	3.76	Yes	Yes	0	8	8
1045	S:S:D484	S:S:R186	4.76	No	Yes	4	4	8
1046	S:S:N419	S:S:T187	5.85	No	No	0	7	7
1047	S:S:F479	S:S:T187	2.59	No	No	0	7	7
1048	S:S:I188	S:S:P189	3.39	Yes	No	0	8	8
1049	S:S:I188	S:S:L323	2.85	Yes	No	0	8	4
1050	S:S:I188	S:S:N419	2.83	Yes	No	0	8	7
1051	S:S:P189	S:S:Y489	4.17	No	No	0	8	8
1052	S:S:D191	S:S:N190	5.39	No	No	0	1	8
1053	S:S:E192	S:S:N190	3.94	No	No	10	4	8
1054	S:S:E192	S:S:K226	14.85	No	Yes	10	4	6
1055	S:S:H193	S:S:V513	5.54	No	No	0	8	3
1056	S:S:M198	S:S:Q194	4.08	Yes	Yes	5	6	6
1057	S:S:Q194	S:S:S297	5.78	Yes	No	0	6	7
1058	S:S:E298	S:S:Q194	5.1	No	Yes	0	6	6
1059	S:S:F321	S:S:Q194	4.68	Yes	Yes	5	5	6
1060	S:S:Q194	S:S:Y489	4.51	Yes	No	0	6	8
1061	S:S:A195	S:S:K226	3.21	No	Yes	0	4	6
1062	S:S:E230	S:S:T196	7.06	Yes	No	0	6	7
1063	S:S:A197	S:S:F321	2.77	No	Yes	0	6	5
1064	S:S:A197	S:S:Y511	9.34	No	Yes	0	6	6
1065	S:S:M198	S:S:V269	3.04	Yes	Yes	5	6	5
1066	S:S:F271	S:S:M198	8.71	Yes	Yes	0	5	6
1067	S:S:F321	S:S:M198	4.98	Yes	Yes	5	5	6
1068	S:S:A199	S:S:F227	2.77	No	Yes	0	5	3
1069	S:S:A199	S:S:R234	5.53	No	Yes	0	5	5
1070	S:S:D200	S:S:E203	2.6	No	No	10	8	5
1071	S:S:D200	S:S:R234	10.72	No	Yes	10	8	5
1072	S:S:D200	S:S:Y511	3.45	No	Yes	0	8	6
1073	S:S:F205	S:S:I201	2.51	Yes	Yes	5	4	6
1074	S:S:F321	S:S:I201	5.02	Yes	Yes	5	5	6
1075	S:S:I201	S:S:I491	2.94	Yes	No	5	6	4
1076	S:S:I201	S:S:L521	7.14	Yes	Yes	5	6	1
1077	S:S:I201	S:S:I523	4.42	Yes	Yes	5	6	5
1078	S:S:I202	S:S:V210	4.61	Yes	No	0	4	8
1079	S:S:F227	S:S:I202	2.51	Yes	Yes	0	3	4
1080	S:S:I202	S:S:I236	4.42	Yes	No	0	4	9
1081	S:S:I202	S:S:L295	2.85	Yes	Yes	0	4	7
1082	S:S:E203	S:S:R234	13.96	No	Yes	10	5	5
1083	S:S:F205	S:S:Y204	9.28	Yes	Yes	5	4	8
1084	S:S:L521	S:S:Y204	3.52	Yes	Yes	5	1	8
1085	S:S:I523	S:S:Y204	9.67	Yes	Yes	5	5	8
1086	S:S:E525	S:S:Y204	7.86	Yes	Yes	5	3	8
1087	S:S:F205	S:S:W207	11.02	Yes	Yes	5	4	6
1088	S:S:F205	S:S:I523	3.77	Yes	Yes	5	4	5
1089	S:S:E525	S:S:F205	12.83	Yes	Yes	5	3	4
1090	S:S:F205	S:S:I528	3.77	Yes	Yes	5	4	3
1091	S:S:F205	S:S:W530	10.02	Yes	Yes	5	4	4
1092	S:S:F205	S:S:V537	2.62	Yes	No	5	4	8
1093	H:H:?7	S:S:R206	4.33	Yes	No	6	0	9
1094	H:H:?8	S:S:R206	15.17	No	No	6	0	9
1095	S:S:V267	S:S:W207	13.48	Yes	Yes	5	6	6
1096	S:S:W207	S:S:W530	3.75	Yes	Yes	5	6	4
1097	S:S:S540	S:S:W207	11.12	No	Yes	5	5	6
1098	S:S:N208	S:S:N541	12.26	No	No	6	9	9
1099	S:S:C561	S:S:N208	4.72	Yes	No	6	9	9
1100	H:H:?7	S:S:N208	7.35	Yes	No	6	0	9
1101	S:S:C237	S:S:W209	5.22	Yes	Yes	6	6	8
1102	S:S:D239	S:S:W209	18.98	Yes	Yes	6	7	8
1103	S:S:T264	S:S:W209	6.06	No	Yes	0	6	8
1104	S:S:A265	S:S:W209	3.89	No	Yes	6	6	8
1105	S:S:C542	S:S:W209	18.28	No	Yes	6	8	8
1106	S:S:P559	S:S:W209	4.05	Yes	Yes	6	4	8
1107	S:S:C561	S:S:W209	2.61	Yes	Yes	6	9	8
1108	S:S:V210	S:S:V267	6.41	No	Yes	0	8	6
1109	S:S:F240	S:S:G211	9.03	Yes	No	0	5	5
1110	S:S:I224	S:S:T212	4.56	No	Yes	0	6	5
1111	S:S:F227	S:S:T212	2.59	Yes	Yes	5	3	5
1112	S:S:I238	S:S:T212	6.08	No	Yes	5	8	5
1113	S:S:T212	S:S:V269	3.17	Yes	Yes	5	5	5
1114	S:S:I213	S:S:I244	4.42	Yes	No	6	5	4
1115	S:S:I213	S:S:I260	2.94	Yes	No	0	5	5
1116	S:S:I213	S:S:I268	2.94	Yes	Yes	6	5	7
1117	S:S:I213	S:S:L280	2.85	Yes	No	6	5	4
1118	S:S:A214	S:S:I224	3.25	No	No	0	6	6
1119	S:S:A215	S:S:D217	4.63	No	No	0	7	6
1120	S:S:A215	S:S:S272	3.42	No	No	0	7	4
1121	S:S:A215	S:S:D276	4.63	No	No	0	7	4
1122	S:S:D216	S:S:R221	7.15	No	No	0	6	4
1123	S:S:D216	S:S:L243	5.43	No	No	0	6	5
1124	S:S:D217	S:S:Y219	3.45	No	Yes	0	6	8
1125	S:S:D218	S:S:R221	3.57	Yes	No	0	6	4
1126	S:S:S297	S:S:Y219	5.09	No	Yes	0	7	8
1127	S:S:A299	S:S:Y219	4	No	Yes	1	7	8
1128	S:S:Y219	X:X:W1108	3.86	Yes	Yes	1	8	0
1129	S:S:F271	S:S:G223	4.52	Yes	No	0	5	5
1130	S:S:F271	S:S:I224	7.54	Yes	No	0	5	6
1131	S:S:E225	S:S:R228	5.82	No	No	0	3	4
1132	S:S:E229	S:S:K226	8.1	No	Yes	10	5	6
1133	S:S:E230	S:S:K226	9.45	Yes	Yes	10	6	6
1134	S:S:A231	S:S:F227	4.16	No	Yes	0	4	3
1135	S:S:F227	S:S:I238	2.51	Yes	No	5	3	8
1136	S:S:F227	S:S:V269	6.55	Yes	Yes	5	3	5
1137	S:S:I238	S:S:R228	2.51	No	No	0	8	4
1138	S:S:E229	S:S:E230	5.07	No	Yes	10	5	6
1139	S:S:E230	S:S:E233	5.07	Yes	No	10	6	4
1140	S:S:E230	S:S:R234	6.98	Yes	Yes	10	6	5
1141	S:S:A231	S:S:I236	3.25	No	No	0	4	9
1142	S:S:E233	S:S:R234	12.79	No	Yes	10	4	5
1143	S:S:I236	S:S:R234	2.51	No	Yes	0	9	5
1144	I:I:?1105	S:S:D235	7.48	No	No	40	0	7
1145	S:S:C237	S:S:P559	3.77	Yes	Yes	6	6	4
1146	S:S:C237	S:S:C561	7.28	Yes	Yes	6	6	9
1147	S:S:D239	S:S:F240	3.58	Yes	Yes	6	7	5
1148	S:S:D239	S:S:S263	4.42	Yes	No	6	7	6
1149	S:S:A265	S:S:D239	3.09	No	Yes	6	6	7
1150	S:S:F240	S:S:V259	3.93	Yes	No	0	5	5
1151	S:S:F240	S:S:I260	2.51	Yes	No	0	5	5
1152	S:S:F240	S:S:S263	5.28	Yes	No	6	5	6
1153	S:S:F240	S:S:I268	2.51	Yes	Yes	6	5	7
1154	S:S:E242	S:S:V256	9.98	No	No	0	4	4
1155	S:S:E242	S:S:V259	8.56	No	No	0	4	5
1156	S:S:I244	S:S:S272	3.1	No	No	0	4	4
1157	S:S:I244	S:S:L280	4.28	No	No	6	4	4
1158	S:S:S245	S:S:S248	3.26	No	No	0	3	2
1159	S:S:Q246	S:S:Y247	12.4	No	No	0	3	3
1160	S:S:P275	S:S:Q246	3.16	Yes	No	0	5	3
1161	S:S:I253	S:S:S248	4.64	No	No	0	2	2
1162	S:S:D249	S:S:E250	5.2	No	No	0	1	2
1163	S:S:E283	S:S:I253	2.73	Yes	No	0	4	2
1164	S:S:E283	S:S:Q254	6.37	Yes	No	0	4	3
1165	S:S:Q254	S:S:R287	7.01	No	Yes	0	3	6
1166	S:S:E283	S:S:V257	2.85	Yes	No	0	4	2
1167	S:S:I284	S:S:V257	3.07	No	No	0	2	2
1168	S:S:R287	S:S:V257	3.92	Yes	No	0	6	2
1169	S:S:E258	S:S:N262	2.63	No	No	0	3	6
1170	S:S:E258	S:S:R287	8.14	No	Yes	0	3	6
1171	S:S:I260	S:S:I289	2.94	No	Yes	0	5	5
1172	S:S:I289	S:S:Q261	10.98	Yes	No	0	5	4
1173	S:S:P538	S:S:R266	4.32	No	No	0	2	8
1174	S:S:R266	S:S:S540	2.64	No	No	0	8	5
1175	S:S:L295	S:S:V267	2.98	Yes	Yes	0	7	6
1176	S:S:S540	S:S:V267	3.23	No	Yes	5	5	6
1177	S:S:I268	S:S:K292	5.82	Yes	No	6	7	8
1178	S:S:I268	S:S:W294	7.05	Yes	Yes	6	7	7
1179	S:S:L295	S:S:V269	5.96	Yes	Yes	0	7	5
1180	S:S:S272	S:S:V270	3.23	No	No	0	4	7
1181	S:S:L277	S:S:V270	4.47	Yes	No	19	1	7
1182	S:S:V270	S:S:W300	9.81	No	Yes	19	7	6
1183	S:S:F271	S:S:S297	6.61	Yes	No	0	5	7
1184	S:S:P275	S:S:S273	3.56	Yes	No	1	5	3
1185	S:S:D276	S:S:S273	7.36	No	No	1	4	3
1186	S:S:G274	S:S:P275	4.06	No	Yes	1	1	5
1187	S:S:G274	S:S:S303	3.71	No	No	1	1	1
1188	M:M:?1103	S:S:G274	3.14	No	No	1	0	1
1189	S:S:D276	S:S:P275	3.22	No	Yes	1	4	5
1190	S:S:L305	S:S:P275	3.28	Yes	Yes	1	4	5
1191	S:S:I281	S:S:L277	4.28	Yes	Yes	19	3	1
1192	S:S:L277	S:S:W300	11.39	Yes	Yes	19	1	6
1193	S:S:I306	S:S:L277	5.71	No	Yes	19	5	1
1194	S:S:E278	S:S:K282	5.4	No	No	0	1	6
1195	S:S:E278	S:S:L305	3.98	No	Yes	1	1	4
1196	S:S:I284	S:S:L280	2.85	No	No	0	2	4
1197	S:S:I281	S:S:I306	4.42	Yes	No	19	3	5
1198	S:S:F311	S:S:I281	8.79	No	Yes	0	4	3
1199	S:S:I281	S:S:I315	4.42	Yes	No	0	3	5
1200	S:S:E283	S:S:R286	10.47	Yes	No	0	4	4
1201	S:S:I284	S:S:I289	5.89	No	Yes	0	2	5
1202	S:S:F311	S:S:V285	6.55	No	No	0	4	3
1203	S:S:V285	S:S:V314	4.81	No	No	0	3	6
1204	S:S:R286	S:S:R287	4.26	No	Yes	0	4	6
1205	S:S:N288	S:S:T290	8.77	No	No	49	4	4
1206	H:H:?12	S:S:N288	29.4	No	No	49	0	4
1207	S:S:I289	S:S:K292	2.91	Yes	No	0	5	8
1208	S:S:T290	S:S:V314	7.93	No	No	0	4	6
1209	H:H:?12	S:S:T290	5.26	No	No	49	0	4
1210	S:S:K292	S:S:W294	3.48	No	Yes	6	8	7
1211	S:S:I293	S:S:S317	7.74	No	No	0	6	6
1212	S:S:I293	S:S:W530	3.52	No	Yes	5	6	4
1213	S:S:I293	S:S:P538	5.08	No	No	5	6	2
1214	S:S:I315	S:S:W294	8.22	No	Yes	0	5	7
1215	S:S:I319	S:S:L295	2.85	No	Yes	0	8	7
1216	S:S:A296	S:S:W300	9.08	No	Yes	0	8	6
1217	S:S:E298	S:S:L323	5.3	No	No	0	6	4
1218	S:S:E298	X:X:W1108	5.45	No	Yes	0	6	0
1219	S:S:A299	X:X:W1108	6.48	No	Yes	1	7	0
1220	S:S:I306	S:S:W300	5.87	No	Yes	19	5	6
1221	M:M:?1103	S:S:S303	5.51	No	No	1	0	1
1222	S:S:P407	S:S:S304	3.56	No	No	0	4	1
1223	S:S:A307	S:S:W494	3.89	No	Yes	20	3	6
1224	S:S:A307	S:S:V503	5.09	No	No	20	3	2
1225	S:S:A307	S:S:F505	2.77	No	No	20	3	5
1226	S:S:M308	S:S:P309	3.35	No	No	50	2	3
1227	S:S:E310	S:S:M308	4.06	No	No	50	2	2
1228	S:S:F311	S:S:M308	7.46	No	No	0	4	2
1229	S:S:E310	S:S:P309	6.29	No	No	50	2	3
1230	S:S:F312	S:S:G316	3.01	Yes	No	0	3	7
1231	S:S:F312	S:S:W494	3.01	Yes	Yes	20	3	6
1232	S:S:F312	S:S:L496	6.09	Yes	No	0	3	3
1233	S:S:F312	S:S:V503	3.93	Yes	No	20	3	2
1234	S:S:T318	S:S:W494	20.62	No	Yes	0	6	6
1235	S:S:I319	S:S:N493	7.08	No	Yes	5	8	5
1236	S:S:I319	S:S:I528	2.94	No	Yes	5	8	3
1237	S:S:F321	S:S:I491	5.02	Yes	No	5	5	4
1238	S:S:A322	S:S:R415	5.53	No	No	0	4	4
1239	S:S:K324	S:S:N488	2.8	No	Yes	17	5	8
1240	S:S:K324	S:S:S490	3.06	No	No	0	5	8
1241	S:S:H510	S:S:K324	6.55	Yes	No	17	5	5
1242	S:S:A325	S:S:H413	4.39	No	No	0	4	6
1243	S:S:G326	S:S:Y418	10.14	No	Yes	0	4	7
1244	S:S:M473	S:S:Q327	2.72	Yes	No	0	5	6
1245	S:S:F331	S:S:I328	8.79	Yes	Yes	1	4	4
1246	S:S:I328	S:S:L414	4.28	Yes	Yes	1	4	5
1247	S:S:I328	S:S:Y418	3.63	Yes	Yes	1	4	7
1248	S:S:I328	S:S:Y421	12.09	Yes	Yes	1	4	8
1249	S:S:F331	S:S:L335	9.74	Yes	No	1	4	4
1250	S:S:F331	S:S:L414	3.65	Yes	Yes	1	4	5
1251	S:S:F331	S:S:S417	2.64	Yes	Yes	1	4	7
1252	S:S:E333	S:S:R332	4.65	No	No	0	8	3
1253	S:S:Q336	S:S:R332	3.5	No	No	0	4	3
1254	S:S:F411	S:S:R332	12.83	No	No	0	4	3
1255	S:S:L335	S:S:Y408	9.38	No	Yes	1	4	5
1256	S:S:M409	S:S:Q336	6.8	No	No	0	6	4
1257	S:S:F352	S:S:V338	2.62	Yes	Yes	1	8	4
1258	S:S:V338	S:S:Y408	5.05	Yes	Yes	1	4	5
1259	S:S:H339	S:S:P340	10.68	Yes	No	1	7	4
1260	S:S:H339	S:S:K341	6.55	Yes	No	0	7	3
1261	S:S:H339	S:S:K342	18.34	Yes	No	0	7	4
1262	S:S:H339	S:S:W353	3.17	Yes	Yes	1	7	7
1263	S:S:G397	S:S:H339	3.18	No	Yes	1	3	7
1264	S:S:P340	S:S:W353	16.21	No	Yes	1	4	7
1265	S:S:L361	S:S:P340	3.28	No	No	0	2	4
1266	S:S:A349	S:S:S343	3.42	No	No	0	4	3
1267	S:S:F348	S:S:N346	4.83	Yes	Yes	1	5	2
1268	S:S:E354	S:S:K350	8.1	No	No	0	3	5
1269	S:S:F352	S:S:W353	4.01	Yes	Yes	1	8	7
1270	S:S:F352	S:S:T356	7.78	Yes	No	1	8	8
1271	S:S:F352	S:S:I401	5.02	Yes	No	0	8	4
1272	S:S:F352	S:S:Y408	9.28	Yes	Yes	1	8	5
1273	S:S:F357	S:S:W353	17.04	Yes	Yes	1	2	7
1274	S:S:G397	S:S:W353	2.81	No	Yes	1	3	7
1275	S:S:E399	S:S:W353	5.45	Yes	Yes	1	4	7
1276	S:S:F357	S:S:T356	11.67	Yes	No	1	2	8
1277	S:S:C359	S:S:F357	2.79	No	Yes	0	4	2
1278	S:S:E399	S:S:F357	13.99	Yes	Yes	1	4	2
1279	S:S:F357	S:S:V404	2.62	Yes	No	0	2	3
1280	S:S:C359	S:S:C395	7.28	No	No	0	4	6
1281	S:S:C395	S:S:L361	3.17	No	No	0	6	2
1282	S:S:D398	S:S:T396	7.23	No	No	1	8	6
1283	S:S:E399	S:S:T396	4.23	Yes	No	1	4	6
1284	S:S:D398	S:S:E399	3.9	No	Yes	1	8	4
1285	S:S:N400	S:S:T402	10.24	No	No	25	7	2
1286	S:S:N400	S:S:S403	7.45	No	No	25	7	4
1287	H:H:?13	S:S:N400	30.62	No	No	25	0	7
1288	H:H:?13	S:S:T402	14.46	No	No	25	0	2
1289	H:H:?13	S:S:S403	2.68	No	No	25	0	4
1290	S:S:P407	S:S:T406	3.5	No	No	1	4	3
1291	S:S:T406	S:S:Y408	3.75	No	Yes	1	3	5
1292	S:S:M409	S:S:Y408	4.79	No	Yes	0	6	5
1293	S:S:F411	S:S:L414	6.09	No	Yes	0	4	5
1294	S:S:H413	S:S:T412	8.21	No	No	0	6	6
1295	S:S:H413	S:S:R415	11.28	No	No	0	6	4
1296	S:S:L414	S:S:S417	4.5	Yes	Yes	1	5	7
1297	S:S:R415	S:S:S490	2.64	No	No	0	4	8
1298	S:S:L422	S:S:Y418	15.24	No	Yes	0	9	7
1299	S:S:S471	S:S:Y418	2.54	No	Yes	1	4	7
1300	S:S:N472	S:S:Y418	4.65	No	Yes	1	4	7
1301	S:S:M473	S:S:Y418	11.97	Yes	Yes	1	5	7
1302	S:S:Y421	S:S:Y425	10.92	Yes	No	1	8	7
1303	S:S:L467	S:S:S426	3	No	No	51	5	5
1304	S:S:F469	S:S:S426	2.64	Yes	No	51	5	5
1305	S:S:F479	S:S:S426	5.28	No	No	0	7	5
1306	S:S:F469	S:S:H429	22.63	Yes	No	0	5	8
1307	S:S:A430	S:S:L464	3.15	No	Yes	0	8	6
1308	S:S:I434	S:S:L431	2.85	Yes	Yes	0	4	7
1309	S:S:L431	S:S:V460	2.98	Yes	No	0	7	6
1310	S:S:Q432	S:S:Y435	5.64	Yes	No	0	4	3
1311	S:S:Q432	S:S:T436	2.83	Yes	No	0	4	5
1312	S:S:D433	S:S:H463	2.52	No	No	0	6	6
1313	S:S:I434	S:S:I452	2.94	Yes	Yes	0	4	1
1314	S:S:I434	S:S:V455	3.07	Yes	No	0	4	5
1315	S:S:H463	S:S:I434	2.65	No	Yes	0	6	4
1316	S:S:I452	S:S:Y435	6.04	Yes	No	0	1	3
1317	S:S:C437	S:S:C449	7.28	No	No	52	3	3
1318	S:S:P439	S:S:T438	5.25	No	No	0	2	3
1319	S:S:K441	S:S:T438	3	No	No	0	4	3
1320	S:S:H463	S:S:L443	3.86	No	No	0	6	3
1321	S:S:H466	S:S:L443	5.14	No	No	0	7	3
1322	S:S:A450	S:S:F444	4.16	No	Yes	9	3	1
1323	S:S:F444	S:S:W458	5.01	Yes	Yes	9	1	7
1324	S:S:F444	S:S:Q459	7.03	Yes	Yes	9	1	6
1325	S:S:N446	S:S:T445	7.31	No	No	9	1	5
1326	S:S:S448	S:S:T445	3.2	No	No	9	6	5
1327	S:S:N446	S:S:S448	8.94	No	No	9	1	6
1328	S:S:A450	S:S:Q459	4.55	No	Yes	9	3	6
1329	S:S:D451	S:S:K453	11.06	No	No	0	3	3
1330	S:S:D451	S:S:K454	2.77	No	No	0	3	2
1331	S:S:Q459	S:S:V455	2.87	Yes	No	0	6	5
1332	S:S:E456	S:S:W458	8.72	No	Yes	9	6	7
1333	S:S:E456	S:S:Q459	6.37	No	Yes	9	6	6
1334	S:S:Q459	S:S:W458	14.24	Yes	Yes	9	6	7
1335	S:S:H466	S:S:K462	9.17	No	No	0	7	5
1336	S:S:L464	S:S:L467	2.77	Yes	No	0	6	5
1337	S:S:F469	S:S:L467	6.09	Yes	No	51	5	5
1338	S:S:N468	S:S:Q476	6.6	No	No	26	8	6
1339	S:S:D478	S:S:N468	10.77	No	No	26	8	8
1340	H:H:?14	S:S:N468	29.4	No	No	26	0	8
1341	S:S:F469	S:S:V477	14.42	Yes	No	0	5	3
1342	S:S:Q476	S:S:T470	5.67	No	No	0	6	6
1343	S:S:M473	S:S:S471	3.07	Yes	No	1	5	4
1344	S:S:E475	S:S:S471	2.87	No	No	1	3	4
1345	S:S:M473	S:S:N472	5.61	Yes	No	1	5	4
1346	S:S:E475	S:S:M473	8.12	No	Yes	1	3	5
1347	S:S:E475	S:S:G474	3.27	No	No	0	3	5
1348	H:H:?14	S:S:Q476	14.25	No	No	26	0	6
1349	H:H:?14	S:S:D478	3.63	No	No	26	0	8
1350	S:S:D480	S:S:E481	6.5	No	No	4	4	7
1351	S:S:D480	S:S:F482	7.17	No	No	4	4	7
1352	S:S:D480	S:S:D484	2.66	No	No	4	4	4
1353	S:S:E481	S:S:F482	16.32	No	No	4	7	7
1354	S:S:D484	S:S:F482	3.58	No	No	4	4	7
1355	S:S:V486	S:S:Y514	3.79	No	No	0	5	5
1356	S:S:H510	S:S:N488	8.93	Yes	Yes	17	5	8
1357	S:S:N488	S:S:N512	6.81	Yes	Yes	17	8	3
1358	H:H:?5	S:S:N488	26.95	Yes	Yes	17	0	8
1359	S:S:E507	S:S:S490	10.06	No	No	0	7	8
1360	S:S:G509	S:S:I491	3.53	No	No	0	1	4
1361	S:S:F505	S:S:I492	6.28	No	No	0	5	9
1362	S:S:H495	S:S:N493	7.65	No	Yes	0	3	5
1363	S:S:N493	S:S:V508	2.96	Yes	No	5	5	9
1364	S:S:I528	S:S:N493	2.83	Yes	Yes	5	3	5
1365	S:S:V503	S:S:W494	7.36	No	Yes	20	2	6
1366	S:S:F505	S:S:W494	8.02	No	Yes	20	5	6
1367	S:S:E506	S:S:H495	24.62	No	No	0	5	3
1368	S:S:H495	S:S:L529	10.29	No	No	0	3	8
1369	S:S:D500	S:S:S497	10.31	No	No	0	4	3
1370	S:S:E499	S:S:P498	9.43	No	No	0	6	5
1371	S:S:D500	S:S:G501	5.03	No	No	0	4	4
1372	S:S:D500	S:S:S502	7.36	No	No	0	4	3
1373	S:S:E506	S:S:V504	2.85	No	No	0	5	5
1374	S:S:K527	S:S:V508	3.04	No	No	0	7	9
1375	S:S:I528	S:S:V508	4.61	Yes	No	5	3	9
1376	S:S:H510	S:S:N512	2.55	Yes	Yes	17	5	3
1377	H:H:?5	S:S:H510	12.62	Yes	Yes	17	0	5
1378	S:S:V513	S:S:Y511	2.52	No	Yes	0	3	6
1379	S:S:R520	S:S:Y511	9.26	No	Yes	0	6	6
1380	S:S:L521	S:S:Y511	3.52	Yes	Yes	0	1	6
1381	S:S:N512	S:S:Y514	5.81	Yes	No	17	3	5
1382	H:H:?5	S:S:N512	19.6	Yes	Yes	17	0	3
1383	H:H:?5	S:S:Y514	11.5	Yes	No	17	0	5
1384	S:S:E519	S:S:K516	17.55	No	No	0	4	1
1385	S:S:K517	S:S:R520	11.14	No	No	0	3	6
1386	S:S:E519	S:S:G518	4.91	No	No	0	4	4
1387	S:S:I523	S:S:L521	8.56	Yes	Yes	5	5	1
1388	S:S:E525	S:S:I523	4.1	Yes	Yes	5	3	5
1389	S:S:N524	S:S:N526	5.45	No	No	0	3	3
1390	S:S:K527	S:S:N524	6.99	No	No	0	7	3
1391	S:S:E525	S:S:I528	4.1	Yes	Yes	5	3	3
1392	S:S:I528	S:S:W530	11.74	Yes	Yes	5	3	4
1393	S:S:V537	S:S:W530	6.13	No	Yes	5	8	4
1394	S:S:P538	S:S:W530	10.81	No	Yes	5	2	4
1395	S:S:F533	S:S:S531	6.61	No	No	0	4	1
1396	S:S:F533	S:S:S534	2.64	No	No	0	4	3
1397	S:S:F539	S:S:N541	8.46	No	No	6	9	9
1398	S:S:F539	S:S:R544	14.97	No	No	0	9	6
1399	H:H:?7	S:S:F539	5.43	Yes	No	6	0	9
1400	H:H:?7	S:S:N541	25.72	Yes	No	6	0	9
1401	S:S:C542	S:S:C561	3.64	No	Yes	6	8	9
1402	S:S:C542	S:S:C562	7.28	No	Yes	6	8	8
1403	S:S:C562	S:S:S543	3.44	Yes	No	0	8	5
1404	S:S:F563	S:S:S543	10.57	No	No	0	6	5
1405	S:S:D545	S:S:D578	13.31	No	Yes	0	9	7
1406	H:H:?7	S:S:D545	6.05	Yes	No	0	0	9
1407	S:S:C546	S:S:K552	3.23	Yes	No	18	2	5
1408	S:S:C546	S:S:F563	2.79	Yes	No	18	2	6
1409	S:S:C546	S:S:C565	3.64	Yes	No	18	2	4
1410	S:S:C546	S:S:D578	4.67	Yes	Yes	18	2	7
1411	S:S:D567	S:S:T550	2.89	No	Yes	0	9	6
1412	S:S:R551	S:S:V566	7.85	No	No	0	8	3
1413	S:S:C582	S:S:R551	4.18	Yes	No	0	1	8
1414	S:S:F563	S:S:K552	22.33	No	No	18	6	5
1415	S:S:D578	S:S:K552	9.68	Yes	No	18	7	5
1416	S:S:E558	S:S:I555	6.83	Yes	No	0	5	7
1417	S:S:E558	S:S:P559	3.14	Yes	Yes	6	5	4
1418	S:S:C562	S:S:E558	3.04	Yes	Yes	6	8	5
1419	S:S:C561	S:S:P559	3.77	Yes	Yes	6	9	4
1420	S:S:C562	S:S:P559	3.77	Yes	Yes	6	8	4
1421	S:S:E564	S:S:V566	4.28	No	No	0	9	3
1422	S:S:C568	S:S:S574	5.16	No	Yes	53	5	8
1423	S:S:C568	S:S:C582	7.28	No	Yes	53	5	1
1424	S:S:E572	S:S:P569	12.58	No	No	0	8	6
1425	S:S:D570	S:S:H595	11.35	No	No	0	7	6
1426	S:S:G571	S:S:W590	8.44	No	No	0	7	8
1427	S:S:G571	S:S:S591	3.71	No	No	0	7	8
1428	S:S:C582	S:S:E572	6.08	Yes	No	0	1	8
1429	S:S:E572	S:S:K584	9.45	No	No	0	8	9
1430	S:S:D583	S:S:Y573	4.6	No	Yes	0	4	8
1431	S:S:C585	S:S:Y573	10.75	No	Yes	54	5	8
1432	S:S:C598	S:S:Y573	6.72	Yes	Yes	54	4	8
1433	S:S:C582	S:S:S574	3.44	Yes	Yes	53	1	8
1434	S:S:D578	S:S:T577	4.34	Yes	No	0	7	7
1435	S:S:C585	S:S:C598	7.28	No	Yes	54	5	4
1436	S:S:D588	S:S:P586	6.44	No	No	0	5	4
1437	S:S:E587	S:S:I761	4.1	No	Yes	0	6	6
1438	S:S:D588	S:S:Y589	13.79	No	No	0	5	6
1439	S:S:C598	S:S:Y589	2.69	Yes	No	0	4	6
1440	S:S:P600	S:S:Y589	19.47	No	No	0	8	6
1441	S:S:E759	S:S:W590	14.17	No	No	0	5	8
1442	S:S:N594	S:S:T596	4.39	No	No	0	5	3
1443	S:S:I599	S:S:P600	3.39	No	No	0	4	8
1444	S:S:H754	S:S:K601	2.62	No	No	55	4	2
1445	S:S:I761	S:S:K601	2.91	Yes	No	55	6	2
1446	S:S:I760	S:S:Q602	4.12	Yes	No	0	8	4
1447	S:S:I603	S:S:I761	4.42	No	Yes	0	6	6
1448	S:S:I603	S:S:I763	4.42	No	Yes	0	6	6
1449	S:S:E604	S:S:I760	2.73	No	Yes	56	7	8
1450	S:S:E604	S:S:F762	4.66	No	No	56	7	7
1451	S:S:E604	S:S:K831	4.05	No	No	0	7	5
1452	S:S:F605	S:S:G670	3.01	No	No	0	8	5
1453	S:S:E671	S:S:F605	7	No	No	0	9	8
1454	S:S:F605	S:S:I763	6.28	No	Yes	0	8	6
1455	S:S:E610	S:S:L606	3.98	Yes	No	0	4	7
1456	S:S:K831	S:S:L606	8.46	No	No	0	5	7
1457	S:S:S607	S:S:T609	4.8	No	No	0	5	7
1458	S:S:E610	S:S:S607	4.31	Yes	No	0	4	5
1459	S:S:L666	S:S:W608	5.69	No	No	57	5	4
1460	S:S:I669	S:S:W608	25.84	No	No	57	7	4
1461	S:S:G670	S:S:W608	5.63	No	No	0	5	4
1462	S:S:E610	S:S:P611	17.29	Yes	No	0	4	7
1463	S:S:E610	S:S:F612	3.5	Yes	No	0	4	8
1464	S:S:I839	S:S:L616	5.71	No	No	0	8	5
1465	S:S:L622	S:S:L626	2.77	No	No	0	6	8
1466	S:S:G623	S:S:L626	3.42	No	No	0	5	8
1467	S:S:F662	S:S:G623	3.01	Yes	No	21	7	5
1468	S:S:F846	S:S:G623	3.01	No	No	21	8	5
1469	S:S:I624	S:S:T627	3.04	No	Yes	21	3	2
1470	S:S:F662	S:S:I624	10.05	Yes	No	21	7	3
1471	S:S:F625	S:S:S628	3.96	No	No	0	3	3
1472	S:S:S628	S:S:T627	3.2	No	Yes	0	3	2
1473	S:S:F662	S:S:T627	2.59	Yes	Yes	21	7	2
1474	S:S:L849	S:S:T627	2.95	No	Yes	0	2	2
1475	S:S:F629	S:S:V633	3.93	No	No	0	7	9
1476	S:S:F853	S:S:V630	5.24	Yes	No	0	3	5
1477	S:S:L631	S:S:L655	6.92	No	No	0	1	4
1478	S:S:G632	S:S:T635	3.64	No	No	0	6	4
1479	S:S:G632	S:S:K636	3.49	No	No	0	6	4
1480	S:S:K636	S:S:V633	3.04	No	No	0	4	9
1481	S:S:F634	S:S:K644	16.13	No	No	0	4	9
1482	S:S:F634	S:S:S651	2.64	No	No	0	4	7
1483	S:S:F637	S:S:K636	11.17	No	No	0	6	4
1484	S:S:N639	S:S:R638	19.28	No	No	27	9	4
1485	S:S:R638	S:S:R648	8.53	No	Yes	27	4	7
1486	S:S:R638	S:S:Y652	3.09	No	Yes	27	4	6
1487	S:S:N639	S:S:R648	4.82	No	Yes	27	9	7
1488	S:S:I642	S:S:T640	6.08	No	No	0	9	8
1489	S:S:I642	S:S:R866	8.77	No	No	0	9	9
1490	S:S:K644	S:S:V643	3.04	No	No	0	9	8
1491	S:S:K644	S:S:R648	4.95	No	Yes	0	9	7
1492	S:S:L650	S:S:N647	9.61	Yes	No	0	9	8
1493	S:S:L721	S:S:N647	4.12	No	No	0	4	8
1494	S:S:R648	S:S:Y652	8.23	Yes	Yes	27	7	6
1495	S:S:E649	S:S:Y652	5.61	No	Yes	0	8	6
1496	S:S:E649	S:S:F725	3.5	No	Yes	0	8	4
1497	S:S:C694	S:S:L650	3.17	No	Yes	0	7	9
1498	S:S:L650	S:S:V697	4.47	Yes	Yes	58	9	9
1499	S:S:L650	S:S:Q724	11.98	Yes	No	58	9	6
1500	S:S:S651	S:S:Y652	5.09	No	Yes	0	7	6
1501	S:S:C694	S:S:L654	9.52	No	No	0	7	9
1502	S:S:I695	S:S:L654	2.85	No	No	0	8	9
1503	S:S:F853	S:S:L655	9.74	Yes	No	0	3	4
1504	S:S:F656	S:S:L659	12.18	No	No	0	8	6
1505	S:S:L690	S:S:S657	10.51	No	No	0	8	9
1506	S:S:C691	S:S:S657	6.89	Yes	No	0	6	9
1507	S:S:L658	S:S:L849	6.92	No	No	0	5	2
1508	S:S:C660	S:S:S687	6.89	No	No	0	7	9
1509	S:S:C661	S:S:S687	6.89	Yes	No	0	8	9
1510	S:S:C661	S:S:F688	6.98	Yes	Yes	0	8	8
1511	S:S:F662	S:S:S845	10.57	Yes	No	0	7	6
1512	S:S:F662	S:S:F846	6.43	Yes	No	21	7	8
1513	S:S:F684	S:S:S664	3.96	Yes	No	0	6	7
1514	S:S:I669	S:S:L666	2.85	No	No	57	7	5
1515	S:S:F667	S:S:L679	7.31	No	No	0	8	8
1516	S:S:F667	S:S:R680	3.21	No	Yes	0	8	9
1517	S:S:F668	S:S:R680	23.52	No	Yes	0	8	9
1518	S:S:E837	S:S:F668	9.33	No	No	0	7	8
1519	S:S:E671	S:S:Q673	15.29	No	No	0	9	3
1520	S:S:C677	S:S:P672	5.65	No	Yes	28	6	5
1521	S:S:P672	S:S:R680	2.88	Yes	Yes	28	5	9
1522	S:S:I763	S:S:P672	3.39	Yes	Yes	0	6	5
1523	S:S:C765	S:S:P672	3.77	No	Yes	28	6	5
1524	S:S:Q673	S:S:T676	5.67	No	No	0	3	9
1525	S:S:N674	S:S:R678	10.85	No	Yes	0	4	6
1526	S:S:N674	S:S:S750	7.45	No	No	0	4	3
1527	S:S:C677	S:S:R680	15.32	No	Yes	28	6	9
1528	S:S:C677	S:S:C765	7.28	No	No	28	6	6
1529	S:S:P747	S:S:R678	8.65	No	Yes	0	9	6
1530	S:S:P748	S:S:R678	5.76	No	Yes	0	5	6
1531	S:S:C765	S:S:R680	11.14	No	Yes	28	6	9
1532	S:S:E837	S:S:Q681	6.37	No	No	0	7	5
1533	S:S:F684	S:S:G685	3.01	Yes	No	0	6	6
1534	S:S:F684	S:S:F688	8.57	Yes	Yes	0	6	8
1535	S:S:F684	S:S:I841	15.07	Yes	No	0	6	8
1536	S:S:G685	S:S:L776	5.13	No	No	0	6	8
1537	S:S:F688	S:S:I692	5.02	Yes	No	0	8	9
1538	S:S:F688	S:S:F814	6.43	Yes	No	0	8	7
1539	S:S:A844	S:S:F688	2.77	No	Yes	0	8	8
1540	S:S:V689	S:S:Y779	5.05	No	No	0	6	8
1541	S:S:T780	S:S:V689	4.76	No	No	0	5	6
1542	S:S:I692	S:S:T780	4.56	No	No	0	9	5
1543	S:S:A784	S:S:I692	3.25	No	No	0	2	9
1544	S:S:C731	S:S:S693	3.44	No	No	0	7	7
1545	S:S:I695	S:S:I807	2.94	No	No	0	8	9
1546	S:S:I695	S:S:I852	2.94	No	Yes	0	8	9
1547	S:S:C787	S:S:L696	4.76	No	No	0	9	8
1548	S:S:R701	S:S:V697	2.62	No	Yes	0	9	9
1549	S:S:Q724	S:S:V697	4.3	No	Yes	58	6	9
1550	S:S:K698	S:S:K856	4.31	No	Yes	0	9	8
1551	S:S:N700	S:S:T699	5.85	No	No	0	7	6
1552	S:S:N700	S:S:V702	5.91	No	No	0	7	7
1553	S:S:L704	S:S:R701	10.93	No	No	0	9	9
1554	S:S:L704	S:S:L723	4.15	No	No	0	9	8
1555	S:S:F725	S:S:Q724	22.25	Yes	No	0	4	6
1556	S:S:L726	S:S:L727	5.54	No	No	0	7	7
1557	S:S:F729	S:S:V728	2.62	No	No	0	2	3
1558	S:S:L730	S:S:V734	2.98	No	No	0	5	9
1559	S:S:F733	S:S:T732	3.89	No	No	0	5	3
1560	S:S:F733	S:S:I736	3.77	No	No	0	5	3
1561	S:S:I738	S:S:Q735	8.23	No	No	0	8	4
1562	S:S:L776	S:S:Q735	7.99	No	No	0	8	4
1563	S:S:Q735	S:S:Y779	18.04	No	No	0	4	8
1564	S:S:C739	S:S:I736	4.91	No	No	0	3	3
1565	S:S:I741	S:S:V737	3.07	No	No	0	8	7
1566	S:S:F775	S:S:I738	7.54	No	No	0	8	8
1567	S:S:V740	S:S:Y744	2.52	No	No	0	4	4
1568	S:S:I741	S:S:T745	4.56	No	No	0	8	6
1569	S:S:T745	S:S:W742	4.85	No	Yes	0	6	7
1570	S:S:A746	S:S:W742	2.59	No	Yes	0	8	7
1571	S:S:E767	S:S:W742	7.63	No	Yes	0	7	7
1572	S:S:G768	S:S:W742	4.22	No	Yes	0	9	7
1573	S:S:S769	S:S:W742	11.12	No	Yes	61	3	7
1574	S:S:A772	S:S:W742	11.67	No	Yes	61	8	7
1575	S:S:L743	S:S:Y744	17.58	No	No	0	1	4
1576	S:S:E767	S:S:P748	6.29	No	No	0	7	5
1577	S:S:H766	S:S:S749	2.79	No	No	0	7	6
1578	S:S:H766	S:S:Y751	6.53	No	No	0	7	3
1579	S:S:I761	S:S:R752	2.51	Yes	No	0	6	7
1580	S:S:I763	S:S:R752	5.01	Yes	No	0	6	7
1581	S:S:E755	S:S:N753	6.57	No	No	0	6	4
1582	S:S:L756	S:S:N753	6.87	No	No	0	5	4
1583	S:S:E755	S:S:H754	19.69	No	No	0	6	4
1584	S:S:H754	S:S:I761	2.65	No	Yes	55	4	6
1585	S:S:F762	S:S:L756	6.09	No	No	0	7	5
1586	S:S:E757	S:S:E759	3.81	No	No	0	3	5
1587	S:S:E757	S:S:I760	2.73	No	Yes	0	3	8
1588	S:S:F762	S:S:I760	3.77	No	Yes	56	7	8
1589	S:S:G768	S:S:H766	3.18	No	No	0	9	7
1590	S:S:A772	S:S:S769	3.42	No	No	61	8	3
1591	S:S:L770	S:S:M771	2.83	No	No	0	3	7
1592	S:S:I777	S:S:L773	4.28	Yes	No	0	5	5
1593	S:S:G774	S:S:I777	3.53	No	Yes	0	4	5
1594	S:S:I777	S:S:W818	3.52	Yes	No	0	5	6
1595	S:S:C781	S:S:G778	3.92	No	No	0	4	9
1596	S:S:L783	S:S:Y779	15.24	No	No	0	8	8
1597	S:S:L782	S:S:L783	2.77	No	No	0	9	8
1598	S:S:A784	S:S:F814	4.16	No	No	59	2	7
1599	S:S:A784	S:S:F815	2.77	No	No	59	2	9
1600	S:S:A785	S:S:F815	4.16	No	No	0	5	9
1601	S:S:C787	S:S:M811	6.48	No	No	0	9	9
1602	S:S:F788	S:S:T808	3.89	No	No	0	4	9
1603	S:S:F788	S:S:M811	4.98	No	No	0	4	9
1604	S:S:F788	S:S:L812	9.74	No	No	0	4	8
1605	S:S:F789	S:S:F790	6.43	No	No	0	8	9
1606	S:S:A791	S:S:I807	3.25	No	No	0	8	9
1607	S:S:F792	S:S:R795	19.24	No	Yes	0	7	7
1608	S:S:K796	S:S:R795	8.66	No	Yes	29	9	7
1609	S:S:K805	S:S:R795	25.99	No	Yes	29	5	7
1610	S:S:R795	S:S:T808	18.11	Yes	No	29	7	9
1611	S:S:K796	S:S:K805	4.31	No	No	29	9	5
1612	S:S:E799	S:S:L797	2.65	No	No	0	8	9
1613	S:S:N802	S:S:P798	8.15	No	No	0	9	8
1614	S:S:E803	S:S:N800	5.26	Yes	Yes	22	9	9
1615	S:S:K856	S:S:N800	2.8	Yes	Yes	22	8	9
1616	S:S:E803	S:S:F801	3.5	Yes	No	0	9	9
1617	S:S:F801	S:S:I859	16.33	No	No	0	9	9
1618	S:S:F801	S:S:R866	4.28	No	No	0	9	9
1619	S:S:E803	S:S:F806	11.66	Yes	No	22	9	9
1620	S:S:E803	S:S:N855	9.2	Yes	No	22	9	9
1621	S:S:E803	S:S:K856	10.8	Yes	Yes	22	9	8
1622	S:S:K805	S:S:T808	4.5	No	No	29	5	9
1623	S:S:F806	S:S:N855	14.5	No	No	22	9	9
1624	S:S:I807	S:S:M811	2.92	No	No	0	9	9
1625	S:S:L848	S:S:S810	3	No	No	0	9	9
1626	S:S:C851	S:S:S810	5.16	No	No	60	9	9
1627	S:S:I852	S:S:S810	4.64	Yes	No	60	9	9
1628	S:S:I813	S:S:I816	2.94	No	No	0	9	9
1629	S:S:F814	S:S:F815	11.79	No	No	59	7	9
1630	S:S:A844	S:S:V817	5.09	No	No	0	8	9
1631	S:S:F821	S:S:W818	3.01	Yes	No	0	7	6
1632	S:S:I822	S:S:W818	4.7	No	No	0	8	6
1633	S:S:F821	S:S:Y825	3.09	Yes	No	0	7	7
1634	S:S:F821	S:S:V836	2.62	Yes	No	0	7	9
1635	S:S:A840	S:S:F821	4.16	No	Yes	0	9	7
1636	S:S:I822	S:S:P823	3.39	No	No	0	8	8
1637	S:S:A824	S:S:V836	3.39	No	No	0	9	9
1638	S:S:V833	S:S:Y825	2.52	No	No	0	8	7
1639	S:S:T828	S:S:Y829	3.75	No	Yes	62	5	7
1640	S:S:F832	S:S:T828	6.49	Yes	No	62	7	5
1641	S:S:F832	S:S:Y829	8.25	Yes	Yes	62	7	7
1642	S:S:F832	S:S:K831	3.72	Yes	No	0	7	5
1643	S:S:C851	S:S:I852	4.91	No	Yes	60	9	9
1644	S:S:F853	S:S:I852	5.02	Yes	Yes	0	3	9
1645	S:S:F853	S:S:V857	2.62	Yes	No	0	3	8
1646	S:S:F854	S:S:Y858	9.28	No	No	0	9	8
1647	S:S:K856	S:S:N855	9.79	Yes	No	22	8	9
1648	S:S:I859	S:S:K856	4.36	No	Yes	0	9	8
1649	S:S:F862	S:S:Y858	14.44	No	No	0	7	8
1650	S:S:K863	S:S:S865	4.59	No	No	0	9	6
1651	S:S:N867	S:S:T868	5.85	No	No	0	7	6
1652	L:L:?1103	W:W:W1108	4.18	Yes	Yes	2	0	0
1653	M:M:?1103	X:X:W1108	4.18	No	Yes	1	0	0
1654	H:H:?1	H:H:?2	30.84	Yes	No	0	0	0
1655	H:H:?3	H:H:?4	33.04	Yes	No	8	0	0
1656	H:H:?5	H:H:?6	29.74	Yes	No	0	0	0
1657	H:H:?7	H:H:?8	39.65	Yes	No	6	0	0
1658	R:R:F788	R:R:M811	2.49	No	No	0	4	8
1659	R:R:S607	R:R:W608	2.47	No	No	0	6	4
1660	R:R:F625	R:R:L626	2.44	No	No	0	4	8
1661	R:R:F667	R:R:L666	2.44	Yes	No	0	9	5
1662	R:R:F846	R:R:L849	2.44	No	No	0	9	1
1663	S:S:F479	S:S:L485	2.44	No	No	0	7	3
1664	S:S:F619	S:S:L842	2.44	No	No	0	7	6
1665	S:S:F725	S:S:L653	2.44	Yes	No	0	4	8
1666	S:S:T318	S:S:W294	2.43	No	Yes	0	6	7
1667	S:S:T318	S:S:W300	2.43	No	Yes	0	6	6
1668	R:R:N700	R:R:R701	2.41	No	Yes	0	8	9
1669	R:R:Q261	R:R:R287	2.34	No	Yes	0	3	6
1670	R:R:L323	R:R:Y489	2.34	No	No	0	5	7
1671	R:R:L743	R:R:Y744	2.34	No	No	0	3	4
1672	R:R:E333	R:R:R332	2.33	No	No	0	8	3
1673	R:R:E803	R:R:F801	2.33	Yes	No	0	9	9
1674	S:S:E837	S:S:F821	2.33	No	Yes	0	7	7
1675	S:S:L773	S:S:W742	2.28	No	Yes	0	5	7
1676	R:R:E354	R:R:Y360	2.24	No	No	0	3	3
1677	R:R:E759	R:R:W590	2.18	No	Yes	0	6	8
1678	R:R:G31	R:R:G95	2.11	No	No	0	8	7
1679	S:S:G36	S:S:G37	2.11	No	No	0	6	7
1680	R:R:F854	R:R:Y858	2.06	No	No	0	9	8
1681	R:R:G487	R:R:P189	2.03	No	No	0	4	7
1682	R:R:G223	R:R:P222	2.03	No	Yes	0	5	7
1683	S:S:G487	S:S:P189	2.03	No	No	0	4	8
1684	R:R:Y829	S:S:Y829	1.99	No	Yes	0	8	7
1685	R:R:C781	R:R:G778	1.96	No	No	0	5	9
1686	S:S:C437	S:S:G442	1.96	No	No	52	3	2
1687	S:S:C449	S:S:G442	1.96	No	No	52	3	2
1688	R:R:A145	R:R:G144	1.95	No	No	0	4	6
1689	R:R:A296	R:R:G320	1.95	No	No	0	8	7
1690	R:R:A301	R:R:G320	1.95	No	No	0	5	7
1691	R:R:P393	R:R:P394	1.95	No	No	0	1	9
1692	R:R:A746	R:R:G768	1.95	No	No	0	8	9
1693	S:S:A214	S:S:G220	1.95	No	No	0	6	5
1694	S:S:A296	S:S:G320	1.95	No	No	0	8	6
1695	S:S:A301	S:S:G320	1.95	No	No	0	5	6
1696	S:S:A325	S:S:G326	1.95	No	No	0	4	4
1697	S:S:P393	S:S:P394	1.95	No	No	0	1	9
1698	R:R:C765	R:R:P672	1.88	No	No	0	7	5
1699	R:R:C739	R:R:P682	1.88	No	No	0	3	5
1700	S:S:C739	S:S:P682	1.88	No	No	0	3	5
1701	R:R:A645	R:R:P641	1.87	No	No	0	9	7
1702	S:S:A645	S:S:P641	1.87	No	No	0	9	7
1703	R:R:G549	R:R:S574	1.86	No	Yes	0	6	7
1704	S:S:G147	S:S:S151	1.86	No	Yes	4	8	4
1705	S:S:G147	S:S:S170	1.86	No	No	4	8	7
1706	S:S:G159	S:S:S183	1.86	No	No	0	6	7
1707	S:S:G549	S:S:S574	1.86	No	Yes	0	6	8
1708	R:R:G291	R:R:T290	1.82	No	No	0	6	4
1709	R:R:G474	R:R:T470	1.82	No	No	0	6	7
1710	R:R:G549	R:R:T596	1.82	No	Yes	0	6	1
1711	R:R:C661	R:R:C691	1.82	No	Yes	0	9	7
1712	R:R:G830	R:R:T764	1.82	No	No	0	8	9
1713	S:S:C661	S:S:C691	1.82	Yes	Yes	0	8	6
1714	S:S:G830	S:S:T764	1.82	No	No	0	8	9
1715	S:S:P498	S:S:S497	1.78	No	No	0	5	3
1716	R:R:G316	R:R:I315	1.76	No	Yes	0	8	5
1717	R:R:G847	R:R:I813	1.76	No	Yes	0	7	9
1718	S:S:G778	S:S:I777	1.76	No	Yes	0	9	5
1719	R:R:P439	R:R:T438	1.75	No	No	0	3	2
1720	S:S:P641	S:S:T640	1.75	No	No	0	7	8
1721	R:R:G31	R:R:K30	1.74	No	No	0	8	8
1722	R:R:G440	R:R:K441	1.74	No	No	0	2	3
1723	R:R:G553	R:R:K552	1.74	No	Yes	0	3	6
1724	S:S:G31	S:S:K30	1.74	No	No	0	8	8
1725	R:R:C660	R:R:S663	1.72	No	No	0	7	6
1726	S:S:C598	S:S:S591	1.72	Yes	No	0	4	8
1727	S:S:C661	S:S:S845	1.72	Yes	No	0	8	6
1728	R:R:A301	R:R:S302	1.71	No	No	0	5	5
1729	R:R:G501	R:R:L496	1.71	No	No	0	3	3
1730	R:R:G532	R:R:L529	1.71	No	No	0	1	8
1731	R:R:A579	R:R:S574	1.71	No	Yes	0	3	7
1732	R:R:G623	R:R:L626	1.71	Yes	No	0	7	8
1733	R:R:A683	R:R:S664	1.71	No	No	0	8	7
1734	R:R:G720	R:R:L721	1.71	No	Yes	0	6	3
1735	R:R:C739	R:R:V740	1.71	No	No	0	3	3
1736	S:S:G483	S:S:L185	1.71	No	No	0	7	8
1737	S:S:G532	S:S:L529	1.71	No	No	0	1	8
1738	S:S:A579	S:S:S574	1.71	No	Yes	0	2	8
1739	S:S:A581	S:S:S580	1.71	No	No	0	9	4
1740	S:S:A620	S:S:S665	1.71	No	No	0	3	7
1741	S:S:A804	S:S:S794	1.71	No	No	0	9	9
1742	S:S:A826	S:S:S827	1.71	No	No	0	9	8
1743	R:R:A108	R:R:V150	1.7	No	No	0	6	8
1744	R:R:A108	R:R:V154	1.7	No	Yes	0	6	8
1745	R:R:A423	R:R:V143	1.7	No	No	0	8	9
1746	R:R:G347	R:R:N346	1.7	No	Yes	0	5	1
1747	S:S:A349	S:S:V338	1.7	No	Yes	0	4	4
1748	S:S:G347	S:S:N346	1.7	No	Yes	0	5	2
1749	S:S:G447	S:S:N446	1.7	No	No	0	3	1
1750	S:S:A840	S:S:V817	1.7	No	No	0	9	9
1751	S:S:A843	S:S:V817	1.7	No	No	0	9	9
1752	R:R:C237	R:R:T560	1.69	Yes	No	8	5	9
1753	R:R:I253	R:R:P279	1.69	No	No	0	3	5
1754	R:R:I328	R:R:P329	1.69	Yes	No	0	3	5
1755	R:R:C561	R:R:T560	1.69	No	No	8	9	9
1756	R:R:I763	R:R:P672	1.69	No	No	0	6	5
1757	S:S:C237	S:S:T560	1.69	Yes	No	0	6	9
1758	S:S:I253	S:S:P279	1.69	No	No	0	2	5
1759	S:S:I328	S:S:P329	1.69	Yes	No	0	4	5
1760	S:S:C546	S:S:T550	1.69	Yes	Yes	18	2	6
1761	S:S:C565	S:S:T550	1.69	No	Yes	18	4	6
1762	R:R:D217	R:R:G149	1.68	No	No	0	6	4
1763	R:R:D500	R:R:G501	1.68	No	No	0	5	3
1764	R:R:A791	R:R:T808	1.68	No	No	0	8	9
1765	S:S:D218	S:S:G149	1.68	Yes	No	0	6	4
1766	S:S:K863	S:S:P864	1.67	No	No	0	9	7
1767	R:R:G347	R:R:Q25	1.64	No	No	0	5	3
1768	R:R:E333	R:R:G330	1.64	No	No	0	8	8
1769	R:R:E519	R:R:G518	1.64	No	No	0	3	4
1770	R:R:E564	R:R:G553	1.64	No	No	0	9	3
1771	R:R:E558	R:R:G557	1.64	No	No	0	5	5
1772	R:R:E610	R:R:G613	1.64	Yes	No	0	4	6
1773	R:R:E671	R:R:G670	1.64	No	No	0	9	5
1774	R:R:C787	R:R:I695	1.64	No	No	0	8	9
1775	R:R:L797	R:R:P798	1.64	No	No	0	9	8
1776	S:S:E333	S:S:G330	1.64	No	No	0	8	8
1777	S:S:L547	S:S:P548	1.64	No	No	0	4	9
1778	S:S:E564	S:S:G553	1.64	No	No	0	9	3
1779	S:S:E556	S:S:G557	1.64	No	No	0	7	5
1780	S:S:E558	S:S:G557	1.64	Yes	No	0	5	5
1781	S:S:E610	S:S:G613	1.64	Yes	No	0	4	6
1782	S:S:L679	S:S:P682	1.64	No	No	0	8	5
1783	S:S:L797	S:S:P798	1.64	No	No	0	9	8
1784	R:R:S245	R:R:S248	1.63	No	No	0	4	3
1785	R:R:S497	R:R:S502	1.63	Yes	No	0	3	3
1786	R:R:S820	S:S:S820	1.63	No	No	0	9	9
1787	S:S:N103	S:S:P40	1.63	No	Yes	0	4	4
1788	R:R:A46	R:R:I62	1.62	No	No	0	1	2
1789	R:R:A840	R:R:I839	1.62	No	No	0	9	8
1790	S:S:A46	S:S:I62	1.62	No	No	0	1	2
1791	S:S:S497	S:S:V504	1.62	No	No	0	3	5
1792	S:S:S665	S:S:V838	1.62	No	No	0	7	8
1793	S:S:S693	S:S:V728	1.62	No	No	0	7	3
1794	R:R:A46	R:R:K48	1.61	No	No	0	1	1
1795	R:R:A804	R:R:K805	1.61	No	No	0	9	5
1796	R:R:S241	R:R:T212	1.6	No	Yes	0	5	6
1797	R:R:S448	R:R:T445	1.6	No	No	0	7	4
1798	R:R:S693	R:R:T732	1.6	No	No	0	7	4
1799	R:R:V697	R:R:V728	1.6	No	No	0	9	3
1800	S:S:S241	S:S:T212	1.6	No	Yes	0	5	5
1801	S:S:V697	S:S:V728	1.6	Yes	No	0	9	3
1802	R:R:T356	R:R:V404	1.59	No	No	0	8	3
1803	R:R:T406	R:R:V404	1.59	No	No	0	4	3
1804	R:R:T617	R:R:V621	1.59	No	No	0	1	2
1805	R:R:C694	R:R:L653	1.59	No	No	0	7	9
1806	R:R:C691	R:R:L848	1.59	Yes	No	0	7	8
1807	R:R:C731	R:R:L730	1.59	No	No	0	7	5
1808	S:S:G549	S:S:H595	1.59	No	No	0	6	6
1809	S:S:T617	S:S:V621	1.59	No	No	0	2	2
1810	S:S:T627	S:S:V630	1.59	Yes	No	0	2	5
1811	S:S:C691	S:S:L654	1.59	Yes	No	0	6	9
1812	S:S:C660	S:S:L659	1.59	No	No	0	7	6
1813	S:S:C691	S:S:L848	1.59	Yes	No	0	6	9
1814	R:R:P56	R:R:Q50	1.58	Yes	No	9	1	3
1815	R:R:A835	R:R:L606	1.58	No	No	0	9	7
1816	R:R:A620	R:R:L842	1.58	No	No	0	4	7
1817	R:R:P682	R:R:Q681	1.58	No	Yes	0	5	5
1818	S:S:P137	S:S:Q118	1.58	No	No	0	4	3
1819	S:S:A620	S:S:L842	1.58	No	No	0	3	6
1820	R:R:E587	R:R:P586	1.57	No	No	0	5	4
1821	R:R:E671	R:R:P672	1.57	No	No	0	9	5
1822	R:R:A515	R:R:N512	1.56	No	Yes	0	3	3
1823	S:S:A804	S:S:N802	1.56	No	No	0	9	9
1824	R:R:I492	R:R:S490	1.55	No	No	0	9	7
1825	S:S:I686	S:S:S687	1.55	No	No	0	7	9
1826	R:R:I736	R:R:V740	1.54	No	No	0	3	3
1827	R:R:I738	R:R:V737	1.54	No	No	0	6	7
1828	R:R:I813	R:R:V817	1.54	Yes	No	0	9	9
1829	R:R:I816	R:R:V817	1.54	No	No	0	9	9
1830	S:S:I860	S:S:V643	1.54	No	No	0	6	8
1831	S:S:I839	S:S:V838	1.54	No	No	0	8	8
1832	S:S:M771	S:S:S769	1.53	No	No	0	7	3
1833	S:S:I401	S:S:T402	1.52	No	No	0	4	2
1834	S:S:F846	S:S:G847	1.51	No	No	0	8	8
1835	R:R:L160	S:S:S106	1.5	No	No	0	7	3
1836	R:R:G553	R:R:R551	1.5	No	Yes	0	3	7
1837	R:R:L797	R:R:S794	1.5	No	No	0	9	9
1838	R:R:N119	R:R:S138	1.49	No	No	0	2	5
1839	R:R:L727	R:R:V697	1.49	No	No	0	7	9
1840	R:R:L730	R:R:V734	1.49	No	No	0	5	9
1841	R:R:N288	R:R:V314	1.48	No	No	0	3	6
1842	R:R:N700	R:R:V702	1.48	No	No	0	8	6
1843	S:S:N800	S:S:V643	1.48	Yes	No	0	9	8
1844	R:R:I686	R:R:I736	1.47	No	No	0	7	3
1845	R:R:I816	S:S:I816	1.47	No	No	0	9	9
1846	S:S:L547	S:S:T550	1.47	No	Yes	0	4	6
1847	S:S:D570	S:S:S591	1.47	No	No	0	7	8
1848	R:R:N800	R:R:T646	1.46	No	No	0	9	9
1849	S:S:N800	S:S:T646	1.46	Yes	No	0	9	9
1850	R:R:I452	R:R:K453	1.45	No	No	0	1	2
1851	R:R:G830	R:R:Y829	1.45	No	No	0	8	8
1852	S:S:I452	S:S:K453	1.45	Yes	No	0	1	3
1853	S:S:G830	S:S:Y829	1.45	No	Yes	0	8	7
1854	R:R:K462	S:S:K53	1.44	No	No	0	6	2
1855	R:R:E507	R:R:S490	1.44	No	No	0	8	7
1856	R:R:K516	R:R:K517	1.44	No	No	0	1	4
1857	S:S:E57	S:S:S54	1.44	No	No	0	2	2
1858	S:S:E252	S:S:S248	1.44	No	No	0	3	2
1859	S:S:P393	S:S:R392	1.44	No	No	0	1	2
1860	S:S:E536	S:S:S534	1.44	No	No	0	4	3
1861	R:R:I614	R:R:L618	1.43	No	No	0	4	3
1862	R:R:I786	R:R:L782	1.43	No	No	0	8	9
1863	R:R:I841	R:R:L842	1.43	No	No	0	8	7
1864	S:S:I614	S:S:L618	1.43	No	No	0	4	3
1865	S:S:K350	S:S:L361	1.41	No	No	0	5	2
1866	S:S:C851	S:S:F809	1.4	No	No	0	9	9
1867	S:S:P394	S:S:Y360	1.39	No	No	0	9	3
1868	S:S:A835	S:S:F832	1.39	No	Yes	0	8	7
1869	R:R:D51	S:S:K462	1.38	No	No	0	5	5
1870	R:R:L631	R:R:L655	1.38	No	No	0	3	4
1871	S:S:A515	S:S:R520	1.38	No	No	0	2	6
1872	R:R:E80	R:R:I76	1.37	No	Yes	0	8	7
1873	R:R:E556	R:R:I554	1.37	No	No	0	7	5
1874	R:R:L650	R:R:N647	1.37	Yes	No	0	9	7
1875	R:R:E757	R:R:I760	1.37	No	No	0	4	8
1876	R:R:E354	R:R:K350	1.35	No	No	0	3	4
1877	R:R:E767	R:R:L770	1.33	Yes	No	0	8	4
1878	R:R:A826	R:R:Y825	1.33	No	No	0	9	6
1879	S:S:L52	S:S:Q50	1.33	Yes	No	0	2	3
1880	R:R:R55	R:R:S54	1.32	Yes	No	0	5	2
1881	R:R:N262	R:R:Q261	1.32	No	No	0	7	3
1882	R:R:F444	R:R:S448	1.32	Yes	No	0	1	7
1883	S:S:N119	S:S:Q118	1.32	No	No	0	2	3
1884	S:S:F444	S:S:S448	1.32	Yes	No	9	1	6
1885	R:R:F729	R:R:V728	1.31	No	No	0	3	3
1886	R:R:E799	R:R:N800	1.31	No	No	0	8	9
1887	R:R:E803	R:R:N800	1.31	Yes	No	0	9	9
1888	R:R:F853	R:R:V857	1.31	Yes	No	0	3	8
1889	S:S:R313	S:S:V314	1.31	No	No	0	3	6
1890	S:S:E593	S:S:N592	1.31	No	No	0	3	3
1891	S:S:E593	S:S:N594	1.31	No	No	0	3	5
1892	S:S:F634	S:S:V633	1.31	No	No	0	4	9
1893	R:R:F733	R:R:T732	1.3	No	No	0	5	4
1894	S:S:D249	S:S:E252	1.3	No	No	0	1	3
1895	S:S:D575	S:S:E576	1.3	No	No	0	4	6
1896	S:S:D758	S:S:E759	1.3	No	No	0	4	5
1897	R:R:R701	R:R:T699	1.29	Yes	No	0	9	6
1898	S:S:E57	S:S:Q50	1.27	No	No	0	2	3
1899	S:S:E232	S:S:E233	1.27	No	No	0	3	4
1900	S:S:E242	S:S:Q255	1.27	No	No	0	4	5
1901	S:S:E251	S:S:E252	1.27	No	No	0	4	3
1902	R:R:V486	R:R:Y514	1.26	No	Yes	0	6	5
1903	S:S:F862	S:S:K863	1.24	No	No	0	7	9
1904	S:S:F619	S:S:L618	1.22	No	No	0	7	3
1905	R:R:I136	R:R:Y21	1.21	No	No	0	4	2
1906	S:S:N24	S:S:R26	1.21	No	No	0	4	5
1907	S:S:L743	S:S:R678	1.21	No	Yes	0	1	6
1908	S:S:F725	S:S:N722	1.21	Yes	No	0	4	6
1909	R:R:E707	R:R:F706	1.17	No	No	0	7	5
1910	S:S:E707	S:S:F706	1.17	No	No	0	7	6
1911	S:S:D575	S:S:Y573	1.15	No	Yes	0	4	8
1912	R:R:F522	R:R:H510	1.13	No	Yes	0	7	6
1913	S:S:F522	S:S:H510	1.13	No	Yes	0	6	5
1914	S:S:R678	S:S:W675	1	Yes	No	0	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F39	6.175	6	2	5
2	R:R:P40	4.998	5	2	4
3	R:R:I41	5.71	4	2	7
4	R:R:H42	5.668	5	2	2
5	R:R:F43	9.71	4	2	3
6	R:R:L52	5.1975	4	0	2
7	R:R:R55	4.335	4	9	5
8	R:R:P56	6.258	5	9	1
9	R:R:Y64	7.72667	6	2	3
10	R:R:N65	7.0975	4	0	1
11	R:R:F66	7.05	4	2	5
12	R:R:F69	7.42	5	2	7
13	R:R:W71	7.36333	6	2	4
14	R:R:L72	4.768	5	2	7
15	R:R:Q73	5.966	5	2	7
16	R:R:M75	4.616	5	2	5
17	R:R:I76	3.646	5	2	7
18	R:R:L88	5.635	4	0	9
19	R:R:L94	4.54	4	0	9
20	R:R:Y96	7.47667	6	2	4
21	R:R:R97	3.92167	6	23	8
22	R:R:I98	5.566	5	2	4
23	R:R:F99	6.404	5	0	9
24	R:R:D100	6.304	5	2	7
25	R:R:F115	3.69286	7	23	5
26	R:R:T146	4.938	5	2	3
27	R:R:V154	3.916	5	7	8
28	R:R:L158	4.635	4	7	5
29	R:R:P164	3.37	4	0	7
30	R:R:Q165	6.5125	4	7	7
31	R:R:Y168	6.33333	6	2	5
32	R:R:S170	5	4	7	7
33	R:R:R173	5.594	5	7	3
34	R:R:L174	5.965	4	7	8
35	R:R:L175	6.90833	6	7	8
36	R:R:F181	5.714	5	7	7
37	R:R:F184	6.24429	7	7	6
38	R:R:R186	3.97714	7	7	9
39	R:R:I188	3.506	5	0	8
40	R:R:N190	4.5425	4	7	9
41	R:R:Q194	5.5425	4	0	6
42	R:R:I201	4.13	5	3	6
43	R:R:I202	4.3475	4	0	4
44	R:R:F205	6.20125	8	3	3
45	R:R:W207	7.382	5	3	7
46	R:R:W209	7.95	7	8	7
47	R:R:T212	4.0875	4	3	6
48	R:R:D218	4.09	4	0	7
49	R:R:Y219	4.17571	7	2	8
50	R:R:R221	6.1225	4	0	4
51	R:R:P222	3.59	4	7	7
52	R:R:K226	8.565	4	7	6
53	R:R:F227	3.928	5	3	3
54	R:R:E230	7.615	4	7	6
55	R:R:R234	7.008	5	0	5
56	R:R:C237	3.8375	4	8	5
57	R:R:D239	6.96	4	8	7
58	R:R:F240	4.304	5	8	4
59	R:R:V267	6.415	4	3	6
60	R:R:V269	4.5	4	3	5
61	R:R:F271	4.264	5	3	5
62	R:R:G274	3.655	4	2	1
63	R:R:P275	4.626	5	2	4
64	R:R:L277	4.386	5	11	3
65	R:R:E283	6.768	5	31	3
66	R:R:R287	7.01	5	0	6
67	R:R:W300	6.92167	6	11	5
68	R:R:I306	4.165	4	11	4
69	R:R:I315	3.8425	4	11	5
70	R:R:F321	5.988	5	3	5
71	R:R:I328	4.6	5	2	3
72	R:R:F331	6.32	6	2	4
73	R:R:F334	5.87	4	2	6
74	R:R:L335	6.2225	4	2	4
75	R:R:V338	3.9825	4	2	4
76	R:R:N346	3.83143	7	2	1
77	R:R:F348	3.735	4	2	5
78	R:R:F352	6.49167	6	2	8
79	R:R:W353	10.928	5	2	7
80	R:R:E399	8.9	5	2	5
81	R:R:N400	13.7475	4	2	6
82	R:R:I401	3.2775	4	2	3
83	R:R:Y408	7.77167	6	2	5
84	R:R:M409	5.01	4	2	6
85	R:R:L414	5.635	4	2	6
86	R:R:Y418	10.205	4	34	7
87	R:R:Y421	7.716	5	2	8
88	R:R:F444	3.74	5	14	1
89	R:R:W458	9.29	5	14	7
90	R:R:Q459	6.99	5	14	7
91	R:R:H463	9.875	4	0	7
92	R:R:M473	4.2425	4	34	6
93	R:R:N488	10.632	5	3	8
94	R:R:N493	4.0675	4	3	6
95	R:R:W494	7.75	7	11	7
96	R:R:S497	3.5875	4	37	3
97	R:R:H510	5.826	5	3	6
98	R:R:Y511	5.848	5	3	5
99	R:R:N512	8.332	5	3	3
100	R:R:V513	4.7925	4	3	3
101	R:R:Y514	7.7825	4	3	5
102	R:R:I523	6	4	3	5
103	R:R:I528	5.414	5	3	3
104	R:R:W530	6.84571	7	3	3
105	R:R:V537	4.0325	4	3	8
106	R:R:P538	6.25	4	3	3
107	R:R:R551	7.0525	4	0	7
108	R:R:K552	8.23	5	0	6
109	R:R:P559	4.47	4	8	3
110	R:R:S574	3.0425	4	39	7
111	R:R:C582	5.245	4	39	1
112	R:R:Y589	5.8125	4	0	7
113	R:R:W590	4.7425	4	41	8
114	R:R:N592	3.9675	4	24	1
115	R:R:T596	3.8475	4	24	1
116	R:R:E610	5.9175	4	0	4
117	R:R:G623	3.165	4	42	7
118	R:R:V633	3.38	4	43	9
119	R:R:R648	7.5475	4	44	7
120	R:R:L650	4.6475	4	13	9
121	R:R:L654	4.89	5	13	9
122	R:R:F662	5.9125	4	42	6
123	R:R:F667	3.0175	4	0	9
124	R:R:R678	6.9825	4	0	6
125	R:R:R680	11.68	5	15	9
126	R:R:Q681	6.285	6	15	5
127	R:R:F684	6.835	4	0	7
128	R:R:F688	6.206	5	0	7
129	R:R:C691	4.1625	4	0	7
130	R:R:R701	4.862	5	46	9
131	R:R:L721	6.5175	4	0	3
132	R:R:Q735	8.4175	4	0	4
133	R:R:W742	7.304	5	15	7
134	R:R:E767	7.07	6	15	8
135	R:R:E803	7.526	5	13	9
136	R:R:I813	2.8975	4	16	9
137	R:R:F814	6.8275	4	45	7
138	R:R:F821	7.3575	4	0	8
139	R:R:F853	3.25	5	0	3
140	R:R:R866	10.245	4	0	9
141	S:S:F39	5.784	5	1	5
142	S:S:P40	4.982	5	1	4
143	S:S:I41	6.118	5	1	7
144	S:S:H42	6.535	6	1	2
145	S:S:F43	10.2	4	1	3
146	S:S:L52	3.326	5	0	2
147	S:S:P56	5.6525	4	14	1
148	S:S:R63	6.7075	4	1	5
149	S:S:Y64	6.76167	6	1	3
150	S:S:F66	6.712	5	1	5
151	S:S:R67	4.82	4	1	4
152	S:S:F69	6.414	5	1	7
153	S:S:W71	6.35167	6	1	4
154	S:S:L72	3.33833	6	1	7
155	S:S:Q73	4.4	7	1	7
156	S:S:M75	5.124	5	1	5
157	S:S:I76	4.575	4	1	7
158	S:S:F77	6.636	5	1	8
159	S:S:E81	6.28	4	1	9
160	S:S:L88	4.725	4	12	9
161	S:S:L89	3.795	4	12	8
162	S:S:Y96	7.48	6	1	4
163	S:S:I98	4.634	5	1	4
164	S:S:F99	6.28	6	4	9
165	S:S:D100	6.685	4	1	7
166	S:S:T101	4.754	5	1	7
167	S:S:F115	5.9975	4	4	5
168	S:S:V142	4.3925	4	4	8
169	S:S:T146	8.005	4	1	4
170	S:S:S151	3.788	5	4	4
171	S:S:V154	4.47	4	4	8
172	S:S:N156	4.0225	4	4	5
173	S:S:L158	3.5975	4	4	5
174	S:S:F161	6.81	4	0	4
175	S:S:P164	3.89	4	0	8
176	S:S:Q165	5.518	5	4	6
177	S:S:Y168	8.476	5	1	5
178	S:S:R173	5.35	5	10	4
179	S:S:L174	5.342	5	10	8
180	S:S:L175	6.846	5	4	7
181	S:S:Q180	4.4925	4	4	6
182	S:S:F181	5.712	5	4	6
183	S:S:F184	7.632	5	4	7
184	S:S:R186	5.012	5	4	8
185	S:S:I188	3.186	5	0	8
186	S:S:Q194	4.83	5	5	6
187	S:S:M198	5.2025	4	5	6
188	S:S:I201	4.406	5	5	6
189	S:S:I202	3.5975	4	0	4
190	S:S:Y204	7.5825	4	5	8
191	S:S:F205	6.9775	8	5	4
192	S:S:W207	9.8425	4	5	6
193	S:S:W209	8.44143	7	6	8
194	S:S:T212	3.6	5	5	5
195	S:S:I213	3.2875	4	6	5
196	S:S:D218	2.7125	4	0	6
197	S:S:Y219	4.005	6	1	8
198	S:S:K226	8.9025	4	10	6
199	S:S:F227	3.515	6	5	3
200	S:S:E230	6.726	5	10	6
201	S:S:R234	8.74833	6	10	5
202	S:S:C237	4.49	4	6	6
203	S:S:D239	7.5175	4	6	7
204	S:S:F240	4.47333	6	6	5
205	S:S:V267	6.525	4	5	6
206	S:S:I268	4.58	4	6	7
207	S:S:V269	4.68	4	5	5
208	S:S:F271	6.845	4	0	5
209	S:S:P275	3.36167	6	1	5
210	S:S:L277	6.4625	4	19	1
211	S:S:I281	5.4775	4	19	3
212	S:S:E283	5.605	4	0	4
213	S:S:R287	5.8325	4	0	6
214	S:S:I289	5.68	4	0	5
215	S:S:W294	5.295	4	6	7
216	S:S:L295	3.66	4	0	7
217	S:S:W300	7.716	5	19	6
218	S:S:L305	5.77	4	1	4
219	S:S:F312	4.01	4	20	3
220	S:S:F321	4.494	5	5	5
221	S:S:I328	5.49833	6	1	4
222	S:S:F331	6.43833	6	1	4
223	S:S:V338	2.972	5	1	4
224	S:S:H339	8.384	5	1	7
225	S:S:N346	3.29833	6	1	2
226	S:S:F348	4.6975	4	1	5
227	S:S:F352	6.64	8	1	8
228	S:S:W353	8.115	6	1	7
229	S:S:F357	9.622	5	1	2
230	S:S:E399	6.8925	4	1	4
231	S:S:Y408	6.28286	7	1	5
232	S:S:L414	4.63	4	1	5
233	S:S:S417	4.418	5	1	7
234	S:S:Y418	8.02833	6	1	7
235	S:S:Y421	8.385	4	1	8
236	S:S:L431	3.146	5	12	7
237	S:S:Q432	5.1125	4	12	4
238	S:S:I434	2.8775	4	0	4
239	S:S:F444	4.38	4	9	1
240	S:S:I452	3.7	4	0	1
241	S:S:W458	9.026	5	9	7
242	S:S:Q459	7.012	5	9	6
243	S:S:L464	3.685	4	0	6
244	S:S:F469	11.445	4	51	5
245	S:S:M473	6.298	5	1	5
246	S:S:N488	11.3725	4	17	8
247	S:S:N493	5.13	4	5	5
248	S:S:W494	8.58	5	20	6
249	S:S:H510	6.356	5	17	5
250	S:S:Y511	5.618	5	0	6
251	S:S:N512	8.6925	4	17	3
252	S:S:L521	5.685	4	5	1
253	S:S:I523	6.104	5	5	5
254	S:S:E525	7.2225	4	5	3
255	S:S:I528	4.99833	6	5	3
256	S:S:W530	7.66167	6	5	4
257	S:S:C546	3.204	5	18	2
258	S:S:T550	1.935	4	18	6
259	S:S:E558	3.6625	4	6	5
260	S:S:P559	3.7	5	6	4
261	S:S:C561	4.404	5	6	9
262	S:S:C562	4.3825	4	6	8
263	S:S:Y573	5.805	4	54	8
264	S:S:S574	3.0425	4	53	8
265	S:S:D578	8	4	18	7
266	S:S:C582	5.245	4	53	1
267	S:S:C598	4.6025	4	54	4
268	S:S:E610	6.144	5	0	4
269	S:S:T627	2.674	5	21	2
270	S:S:R648	6.6325	4	27	7
271	S:S:L650	7.3075	4	58	9
272	S:S:Y652	5.505	4	27	6
273	S:S:C661	4.3525	4	0	8
274	S:S:F662	6.53	5	21	7
275	S:S:P672	3.9225	4	28	5
276	S:S:R678	5.494	5	0	6
277	S:S:R680	11.214	5	28	9
278	S:S:F684	7.6525	4	0	6
279	S:S:F688	5.954	5	0	8
280	S:S:C691	2.9725	4	0	6
281	S:S:V697	3.2475	4	58	9
282	S:S:F725	7.35	4	0	4
283	S:S:W742	6.33714	7	61	7
284	S:S:I760	3.3375	4	56	8
285	S:S:I761	3.318	5	55	6
286	S:S:I763	4.775	4	0	6
287	S:S:I777	3.2725	4	0	5
288	S:S:R795	18	4	29	7
289	S:S:N800	2.75	4	22	9
290	S:S:E803	8.084	5	22	9
291	S:S:F821	3.042	5	0	7
292	S:S:Y829	3.86	4	62	7
293	S:S:F832	4.9625	4	62	7
294	S:S:I852	4.3775	4	60	9
295	S:S:F853	5.655	4	0	3
296	S:S:K856	6.412	5	22	8
297	L:L:?1103	3.9625	4	2	0
298	W:W:W1108	4.254	5	2	0
299	I:I:?1106	6.9425	4	1	0
300	X:X:W1108	4.42429	7	1	0
301	H:H:?1	19.968	5	3	0
302	H:H:?3	16.56	5	8	0
303	H:H:?5	20.082	5	17	0
304	H:H:?7	14.755	6	6	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F115	R:R:L38	20.7033	3.65	Yes	No	0	5	7
2	R:R:L38	R:R:T101	36.5054	2.95	No	No	0	7	7
3	R:R:D100	R:R:T101	28.7182	2.89	Yes	No	0	7	7
4	R:R:D100	R:R:F348	10.261	4.78	Yes	Yes	2	7	5
5	R:R:F348	R:R:N346	10.029	3.62	Yes	Yes	2	5	1
6	R:R:D100	R:R:I41	10.7707	12.59	Yes	Yes	2	7	7
7	R:R:I41	R:R:L72	12.9293	2.85	Yes	Yes	2	7	7
8	R:R:I98	R:R:Y96	11.6368	8.46	Yes	Yes	2	4	4
9	R:R:I163	R:R:L158	10.0937	4.28	No	Yes	0	8	5
10	R:R:F39	R:R:L72	23.7591	9.74	Yes	Yes	2	5	7
11	I:I:?1104	R:R:T101	12.4851	8.12	No	No	0	0	7
12	I:I:?1104	R:R:T146	15.5452	2.71	No	Yes	0	0	3
13	R:R:F39	R:R:Y168	40.2911	10.32	Yes	Yes	2	5	5
14	R:R:L38	R:R:V154	18.1597	2.98	No	Yes	0	7	8
15	R:R:F115	R:R:T112	17.5663	2.59	Yes	No	0	5	5
16	R:R:T112	R:R:V154	23.9165	4.76	No	Yes	0	5	8
17	R:R:I41	R:R:Y64	10.6658	3.63	Yes	Yes	2	7	3
18	R:R:A169	R:R:T146	12.5016	3.36	No	Yes	2	7	3
19	R:R:A169	W:W:W1108	60.4241	3.89	No	Yes	2	7	0
20	S:S:L464	S:S:P164	16.1095	3.28	Yes	Yes	0	6	8
21	S:S:L464	S:S:L467	17.3155	2.77	Yes	No	0	6	5
22	S:S:L467	S:S:S426	17.6079	3	No	No	51	5	5
23	S:S:F479	S:S:S426	29.7477	5.28	No	No	0	7	5
24	S:S:F479	S:S:T187	30.3475	2.59	No	No	0	7	7
25	S:S:N419	S:S:T187	30.6472	5.85	No	No	0	7	7
26	S:S:I188	S:S:N419	30.9469	2.83	Yes	No	0	8	7
27	S:S:I188	S:S:R186	23.0914	3.76	Yes	Yes	0	8	8
28	S:S:F184	S:S:R186	17.7716	6.41	Yes	Yes	4	7	8
29	S:S:F184	S:S:Q165	19.3388	10.54	Yes	Yes	4	7	6
30	S:S:T112	S:S:V154	28.3343	4.76	No	Yes	4	5	8
31	S:S:L157	S:S:T112	39.2147	5.9	No	No	0	7	5
32	R:R:L113	S:S:L157	19.5464	2.77	No	No	0	3	7
33	R:R:L113	R:R:L157	19.5578	2.77	No	No	0	3	7
34	R:R:L157	R:R:T112	39.0808	2.95	No	No	0	7	5
35	S:S:L158	S:S:T112	11.0246	2.95	Yes	No	4	5	5
36	S:S:L113	S:S:L157	19.5464	2.77	No	No	0	3	7
37	R:R:L157	S:S:L113	19.5578	2.77	No	No	0	7	3
38	R:R:F352	R:R:Y64	11.3374	5.16	Yes	Yes	2	8	3
39	R:R:F69	R:R:N346	10.8158	6.04	Yes	Yes	2	7	1
40	R:R:M75	R:R:V424	13.1937	3.04	Yes	No	0	5	7
41	R:R:A78	R:R:V424	12.2137	5.09	No	No	0	7	7
42	R:R:A78	R:R:Y421	11.2428	2.67	No	Yes	0	7	8
43	R:R:Y219	W:W:W1108	33.5305	3.86	Yes	Yes	2	8	0
44	R:R:D218	R:R:T152	11.1408	4.34	Yes	No	0	7	5
45	R:R:E298	W:W:W1108	30.4582	5.45	No	Yes	0	6	0
46	R:R:E298	R:R:Q194	31.3625	5.1	No	Yes	0	6	6
47	R:R:F271	R:R:Q194	31.1522	3.51	Yes	Yes	0	5	6
48	R:R:F271	R:R:S297	44.6161	3.96	Yes	No	0	5	8
49	R:R:S297	R:R:Y219	40.9864	5.09	No	Yes	0	8	8
50	R:R:F271	R:R:V269	70.2684	2.62	Yes	Yes	3	5	5
51	R:R:F227	R:R:V269	30.1208	7.87	Yes	Yes	3	3	5
52	R:R:F227	R:R:I202	32.5992	2.51	Yes	Yes	0	3	4
53	R:R:L295	R:R:V269	46.1287	4.47	No	Yes	0	7	5
54	R:R:I202	R:R:L295	24.2474	2.85	Yes	No	0	4	7
55	R:R:I202	R:R:V210	58.6891	6.14	Yes	No	0	4	8
56	R:R:L295	R:R:V267	26.408	2.98	No	Yes	0	7	6
57	R:R:V210	R:R:V267	25.5543	8.02	No	Yes	0	8	6
58	R:R:D239	R:R:W209	78.4262	16.75	Yes	Yes	8	7	7
59	R:R:D239	R:R:F240	78.6816	3.58	Yes	Yes	8	7	4
60	R:R:F240	R:R:G211	79.483	7.53	Yes	No	0	4	5
61	R:R:G211	R:R:V210	79.6139	3.68	No	No	0	5	8
62	R:R:P559	R:R:W209	76.0093	4.05	Yes	Yes	8	3	7
63	R:R:F227	R:R:I238	18.9461	2.51	Yes	No	3	3	8
64	R:R:S297	R:R:W300	22.6285	3.71	No	Yes	0	8	5
65	R:R:W300	R:R:W494	16.6234	2.81	Yes	Yes	11	5	7
66	R:R:I268	R:R:W294	11.7987	10.57	No	No	0	6	7
67	R:R:I238	R:R:R228	23.762	2.51	No	No	0	8	4
68	R:R:R228	S:S:R228	23.5677	10.66	No	No	0	4	4
69	R:R:N472	R:R:Y421	11.8719	3.49	No	Yes	0	3	8
70	R:R:M473	R:R:N472	10.3881	2.8	Yes	No	0	6	3
71	R:R:F352	R:R:I401	13.8749	2.51	Yes	Yes	2	8	3
72	R:R:I401	R:R:W353	14.4702	4.7	Yes	Yes	2	3	7
73	R:R:G553	R:R:K552	30.0944	1.74	No	Yes	0	3	6
74	R:R:E564	R:R:G553	75.729	1.64	No	No	0	9	3
75	R:R:E564	R:R:I555	75.7767	4.1	No	No	0	9	6
76	R:R:E558	R:R:I555	75.8346	5.47	No	No	0	5	6
77	R:R:E558	R:R:P559	76.329	6.29	No	Yes	0	5	3
78	R:R:G553	R:R:R551	100	1.5	No	Yes	0	3	7
79	R:R:R551	S:S:R551	95.388	15.99	Yes	No	0	7	8
80	R:R:K552	S:S:E556	28.9215	9.45	Yes	No	0	6	7
81	S:S:A215	S:S:S272	33.2165	3.42	No	No	0	7	4
82	S:S:I244	S:S:S272	31.4036	3.1	No	No	0	4	4
83	S:S:I213	S:S:I244	30.0815	4.42	Yes	No	6	5	4
84	S:S:I213	S:S:I260	15.0699	2.94	Yes	No	0	5	5
85	S:S:F240	S:S:I260	15.505	2.51	Yes	No	0	5	5
86	S:S:D239	S:S:F240	30.7326	3.58	Yes	Yes	6	7	5
87	S:S:D239	S:S:W209	30.563	18.98	Yes	Yes	6	7	8
88	S:S:P559	S:S:W209	28.1842	4.05	Yes	Yes	6	4	8
89	S:S:E558	S:S:P559	27.9831	3.14	Yes	Yes	6	5	4
90	S:S:E558	S:S:G557	28.9805	1.64	Yes	No	0	5	5
91	S:S:E556	S:S:G557	29.0199	1.64	No	No	0	7	5
92	S:S:I213	S:S:I268	15.0724	2.94	Yes	Yes	6	5	7
93	S:S:F240	S:S:I268	15.8593	2.51	Yes	Yes	6	5	7
94	S:S:C582	S:S:R551	94.9086	4.18	Yes	No	0	1	8
95	S:S:C582	S:S:S574	94.2837	3.44	Yes	Yes	53	1	8
96	S:S:G549	S:S:S574	94.0668	1.86	No	Yes	0	6	8
97	S:S:G549	S:S:H595	93.9463	1.59	No	No	0	6	6
98	S:S:D570	S:S:H595	93.8257	11.35	No	No	0	7	6
99	S:S:D570	S:S:S591	93.705	1.47	No	No	0	7	8
100	S:S:G571	S:S:S591	92.251	3.71	No	No	0	7	8
101	S:S:G571	S:S:W590	92.1293	8.44	No	No	0	7	8
102	S:S:E759	S:S:W590	92.0076	14.17	No	No	0	5	8
103	S:S:E757	S:S:E759	91.7639	3.81	No	No	0	3	5
104	S:S:E757	S:S:I760	91.642	2.73	No	Yes	0	3	8
105	S:S:E604	S:S:I760	35.6001	2.73	No	Yes	56	7	8
106	S:S:E604	S:S:K831	38.9166	4.05	No	No	0	7	5
107	S:S:F832	S:S:K831	37.7102	3.72	Yes	No	0	7	5
108	S:S:F832	S:S:Y829	37.248	8.25	Yes	Yes	62	7	7
109	R:R:Y829	S:S:Y829	36.8024	1.99	No	Yes	0	8	7
110	R:R:L756	R:R:Y829	36.3474	3.52	No	No	0	4	8
111	R:R:L756	R:R:N753	36.1956	5.49	No	No	0	4	4
112	R:R:E755	R:R:N753	35.5877	9.2	No	No	0	5	4
113	R:R:E755	R:R:H754	35.4356	24.62	No	No	0	5	3
114	R:R:H754	R:R:I761	35.2833	2.65	No	No	0	3	7
115	R:R:I763	R:R:P672	34.6736	1.69	No	No	0	6	5
116	R:R:I763	R:R:R752	34.8262	8.77	No	No	0	6	7
117	R:R:I761	R:R:R752	34.9786	2.51	No	No	0	7	7
118	R:R:C765	R:R:P672	32.8375	1.88	No	No	0	7	5
119	R:R:C765	R:R:R680	30.591	4.18	No	Yes	15	7	9
120	R:R:F684	R:R:S664	24.5789	2.64	Yes	No	0	7	7
121	R:R:A683	R:R:S664	24.736	1.71	No	No	0	8	7
122	R:R:A683	R:R:F667	24.8931	2.77	No	Yes	0	8	9
123	R:R:F667	R:R:R680	25.364	3.21	Yes	Yes	0	9	9
124	R:R:F684	R:R:F688	23.4766	5.36	Yes	Yes	0	7	7
125	R:R:C661	R:R:F688	19.0314	2.79	No	Yes	0	9	7
126	R:R:C661	R:R:C691	18.3916	1.82	No	Yes	0	9	7
127	R:R:F853	R:R:I852	11.4399	5.02	Yes	No	0	3	9
128	R:R:I852	R:R:L848	11.5773	2.85	No	No	16	9	8
129	R:R:C691	R:R:L848	13.3936	1.59	Yes	No	0	7	8
130	S:S:L38	S:S:V154	20.9256	2.98	No	Yes	0	7	8
131	S:S:L38	S:S:T101	20.8979	5.9	No	Yes	0	7	7
132	S:S:D100	S:S:T101	11.1973	2.89	Yes	Yes	1	7	7
133	S:S:F469	S:S:S426	11.8398	2.64	Yes	No	51	5	5
134	S:S:F469	S:S:H429	11.2423	22.63	Yes	No	0	5	8
135	S:S:H429	S:S:L88	10.9392	5.14	No	Yes	0	8	9
136	S:S:S417	S:S:W71	24.3018	4.94	Yes	Yes	1	7	4
137	S:S:W71	X:X:W1108	17.0073	2.81	Yes	Yes	1	4	0
138	S:S:F331	S:S:S417	14.8936	2.64	Yes	Yes	1	4	7
139	S:S:I188	S:S:S171	14.6781	3.1	Yes	No	0	8	6
140	S:S:S171	S:S:Y219	13.6961	2.54	No	Yes	0	6	8
141	S:S:I238	S:S:R228	23.5655	2.51	No	No	0	8	4
142	S:S:F227	S:S:I238	13.0585	2.51	Yes	No	5	3	8
143	S:S:I238	S:S:T212	10.4726	6.08	No	Yes	5	8	5
144	S:S:D217	S:S:Y219	27.1291	3.45	No	Yes	0	6	8
145	S:S:I328	S:S:Y418	14.3173	3.63	Yes	Yes	1	4	7
146	S:S:G326	S:S:Y418	10.3499	10.14	No	Yes	0	4	7
147	S:S:F762	S:S:I760	55.7978	3.77	No	Yes	56	7	8
148	S:S:F762	S:S:L756	59.1246	6.09	No	No	0	7	5
149	S:S:L756	S:S:N753	58.9843	6.87	No	No	0	5	4
150	S:S:E755	S:S:N753	58.8439	6.57	No	No	0	6	4
151	S:S:E755	S:S:H754	58.7035	19.69	No	No	0	6	4
152	S:S:H754	S:S:I761	58.4085	2.65	No	Yes	55	4	6
153	S:S:I603	S:S:I761	29.0705	4.42	No	Yes	0	6	6
154	S:S:I603	S:S:I763	28.9228	4.42	No	Yes	0	6	6
155	S:S:I761	S:S:R752	29.0705	2.51	Yes	No	0	6	7
156	S:S:I763	S:S:R752	28.9228	5.01	Yes	No	0	6	7
157	S:S:I763	S:S:P672	55.1205	3.39	Yes	Yes	0	6	5
158	S:S:P672	S:S:R680	54.198	2.88	Yes	Yes	28	5	9
159	S:S:F668	S:S:R680	51.7819	23.52	No	Yes	0	8	9
160	S:S:E837	S:S:F668	51.4779	9.33	No	No	0	7	8
161	S:S:E837	S:S:F821	50.8698	2.33	No	Yes	0	7	7
162	S:S:A840	S:S:F821	39.8731	4.16	No	Yes	0	9	7
163	S:S:A840	S:S:V817	39.5662	1.7	No	No	0	9	9
164	S:S:A844	S:S:V817	38.9524	5.09	No	No	0	8	9
165	S:S:A844	S:S:F688	38.6453	2.77	No	Yes	0	8	8
166	S:S:C661	S:S:F688	32.4888	6.98	Yes	Yes	0	8	8
167	S:S:C661	S:S:C691	25.0386	1.82	Yes	Yes	0	8	6
168	S:S:C691	S:S:L654	21.2966	1.59	Yes	No	0	6	9
169	S:S:C694	S:S:L654	15.0886	9.52	No	No	0	7	9
170	S:S:C694	S:S:L650	14.776	3.17	No	Yes	0	7	9
171	S:S:L650	S:S:Q724	11.3217	11.98	Yes	No	58	9	6
172	S:S:F725	S:S:Q724	11.0189	22.25	Yes	No	0	4	6
173	S:S:E649	S:S:F725	10.0779	3.5	No	Yes	0	8	4
174	R:R:L72	R:R:N346	13.8406	4.12	Yes	Yes	2	7	1
175	R:R:A169	R:R:Y168	47.7026	2.67	No	Yes	2	7	5
176	S:S:Y219	X:X:W1108	16.7687	3.86	Yes	Yes	1	8	0
177	R:R:F39	R:R:I98	11.2744	2.51	Yes	Yes	2	5	4
178	S:S:A215	S:S:D217	27.122	4.63	No	No	0	7	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:R67	S:S:W71	7	1	Yes	Yes	4	4	2	2
S:S:R67	X:X:W1108	3	1	Yes	Yes	4	0	2	1
S:S:W71	X:X:W1108	2.81	1	Yes	Yes	4	0	2	1
S:S:A169	X:X:W1108	5.19	0	No	Yes	7	0	2	1
S:S:A299	S:S:Y219	4	1	No	Yes	7	8	2	2
S:S:Y219	X:X:W1108	3.86	1	Yes	Yes	8	0	2	1
S:S:G274	S:S:P275	4.06	1	No	Yes	1	5	1	2
S:S:G274	S:S:S303	3.71	1	No	No	1	1	1	1
M:M:?1103	S:S:G274	3.14	1	No	No	0	1	0	1
S:S:E298	X:X:W1108	5.45	0	No	Yes	6	0	2	1
S:S:A299	X:X:W1108	6.48	1	No	Yes	7	0	2	1
M:M:?1103	S:S:S303	5.51	1	No	No	0	1	0	1
M:M:?1103	X:X:W1108	4.18	1	No	Yes	0	0	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
100.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
100.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
100.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
50.00	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
50.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
50.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
50.00	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
50.00	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
50.00	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
50.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
50.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
50.00	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
50.00	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
50.00	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
50.00	Single	7DD5	Ca3	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
50.00	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
50.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
50.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
50.00	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
50.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
50.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
50.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
50.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
50.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
50.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
50.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
50.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
50.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
50.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
50.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
50.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
50.00	Single	7EB2	Baclofen	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
50.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
50.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
50.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
50.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
50.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
50.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
50.00	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
50.00	Single	7FII	hCG	7FII-LH-hCG-6fuf
50.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
50.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
50.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
50.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
50.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
50.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
50.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
50.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
50.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
50.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
50.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
50.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
50.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
50.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
50.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
50.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
50.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
50.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
50.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
50.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
50.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
50.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
50.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
50.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
50.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
50.00	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
50.00	Single	7XW7	K1-70	7XW7-TSH-K1-70
50.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
50.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
50.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
50.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
50.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
50.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
50.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
50.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
50.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
50.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
50.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
50.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
50.00	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-J9R
50.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
50.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
50.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
50.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
50.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
50.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
50.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
50.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
50.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
50.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
50.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
50.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
50.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
50.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
50.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
50.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
50.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
50.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
50.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
50.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
50.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
50.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
50.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
50.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
50.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
50.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
50.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
50.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
50.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
50.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
50.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
50.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
50.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
50.00	Consensus	fsh_on_allo	Orthosteric Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
50.00	Consensus	gabab_off	Orthosteric Ligand	7C7S-GABA_B1, GABA_B2-CGP54626 7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid 6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
50.00	Consensus	gabab_on	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
50.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
50.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
50.00	Consensus	gi_gaba	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
50.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
50.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
50.00	Consensus	gphr_on	Orthosteric Ligand	lh_on tsh_on
50.00	Consensus	gs_gphr	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
50.00	Consensus	gs_protein	Orthosteric Ligand	gs_gphr
50.00	Consensus	lh_on	Orthosteric Ligand	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
50.00	Consensus	lh_on_allo	Orthosteric Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
50.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
50.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
50.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
50.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
50.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
50.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
50.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
50.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
50.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
50.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
50.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
50.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
50.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
50.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
50.00	Consensus	smo_off_allo	Other Ligand	6D32-SMO-Cyclopamine-Cyclopamine
50.00	Consensus	tsh_on	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2
50.00	Consensus	tsh_on_allo	Orthosteric Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
33.33	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
33.33	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
33.33	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
25.00	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
25.00	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
25.00	Single	8HS2	Fab046	8HS2-GPR20-Fab046
20.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
20.00	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
20.00	Single	7UTZ	TR1402	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
20.00	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
20.00	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
16.67	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
16.67	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/&β;1/&γ;2
16.67	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
16.67	Single	8I2G	Glycoprotein hormones alpha chain	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
14.29	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
14.29	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
12.50	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
12.50	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
12.50	Single	6LI0	GTPL9804	6LI0-GPR52-GTPL9804
12.50	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
12.50	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
12.50	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
11.11	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
11.11	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
11.11	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
11.11	Consensus	go_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Consensus	go_protein	Orthosteric Ligand	go_chemokine
11.11	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
10.00	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
10.00	Single	5U09	Taranabant	5U09-CB₁-Taranabant
10.00	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
10.00	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
10.00	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.00	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
10.00	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
10.00	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
10.00	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
10.00	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
10.00	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
10.00	Single	8HMP	PubChem 69921479	8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
10.00	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.00	Consensus	class-f_off	Orthosteric Ligand	smo_off
10.00	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
10.00	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
10.00	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
9.09	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
9.09	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.09	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
9.09	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
9.09	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
9.09	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
9.09	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
9.09	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
9.09	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
9.09	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
9.09	Consensus	gi_class-f	Orthosteric Ligand	gi_frizzled
9.09	Consensus	gi_frizzled	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.09	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
9.09	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
9.09	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
8.33	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
8.33	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
8.33	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
8.33	Single	6D27	CAY10471	6D27-DP₂-CAY10471
8.33	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
8.33	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
8.33	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
8.33	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
8.33	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
8.33	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
8.33	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
8.33	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
8.33	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
8.33	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
8.33	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
8.33	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
8.33	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
8.33	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
8.33	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
8.33	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
8.33	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
7.69	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
7.69	Single	5C1M	BU72	5C1M-μ-BU72
7.69	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
7.69	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
7.69	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
7.69	Single	7C4S	S1P	7C4S-S1P₃-S1P
7.69	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
7.69	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
7.69	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
7.69	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
7.69	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
7.69	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
7.69	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
7.14	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
7.14	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
7.14	Single	5V56	TC114	5V56-SMO-TC114
7.14	Single	5V57	TC114	5V57-SMO-TC114
7.14	Single	6OS1	TRV026	6OS1-AT₁-TRV026
7.14	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
7.14	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
7.14	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
7.14	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.14	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.14	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.14	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
7.14	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
7.14	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
7.14	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.14	Single	8E0G	BU72	8E0G-μ-BU72
7.14	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
7.14	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.14	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
7.14	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
7.14	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.14	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
7.14	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.14	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
7.14	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
7.14	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.14	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
6.67	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
6.67	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
6.67	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
6.67	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
6.67	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
6.67	Single	6OS2	TRV026	6OS2-AT₁-TRV026
6.67	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
6.67	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
6.67	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
6.67	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
6.67	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
6.67	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
6.67	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.67	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
6.67	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
6.67	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
6.67	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
6.67	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
6.67	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
6.67	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
6.67	Consensus	dp_off	Orthosteric Ligand	dp2_off
6.67	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
6.67	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
6.67	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Consensus	nts_on	Orthosteric Ligand	nts1_on
6.67	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
6.67	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.25	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
6.25	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
6.25	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
6.25	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
6.25	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.25	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
6.25	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
6.25	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6.25	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
6.25	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
6.25	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
6.25	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
6.25	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.25	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.25	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.25	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
5.88	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
5.88	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
5.88	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
5.88	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.88	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
5.88	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
5.88	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
5.88	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.88	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
5.88	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
5.88	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
5.88	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
5.88	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
5.88	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
5.56	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
5.56	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.56	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.56	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
5.56	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
5.56	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
5.56	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.56	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
5.56	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.56	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.56	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.56	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
5.56	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.56	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.56	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.56	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
5.56	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
5.26	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
5.26	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.26	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
5.26	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
5.26	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
5.26	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
5.26	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
5.26	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.26	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
5.26	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.26	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.26	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
5.26	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
5.00	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
5.00	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
5.00	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
5.00	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
5.00	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
5.00	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.00	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.00	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
5.00	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
5.00	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.00	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
5.00	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
5.00	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
5.00	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
5.00	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
4.76	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
4.76	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
4.76	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
4.76	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.76	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.76	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
4.76	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
4.76	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.76	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
4.76	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.76	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
4.76	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
4.76	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
4.76	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.76	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.76	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
4.76	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
4.76	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
4.76	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
4.76	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
4.76	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.55	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.55	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
4.55	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.55	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.55	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.55	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.55	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.55	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.55	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.55	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.55	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.55	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
4.55	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
4.55	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.55	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.55	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
4.55	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
4.35	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
4.35	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
4.35	Single	6FJ3	PTH	6FJ3-PTH1-PTH
4.35	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.35	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.35	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.35	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.35	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
4.35	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
4.35	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
4.35	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.35	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
4.35	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
4.35	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.35	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.35	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
4.35	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.35	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.17	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
4.17	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
4.17	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
4.17	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.17	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
4.17	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
4.17	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
4.17	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.17	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.17	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.17	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
4.17	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.17	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
4.17	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
4.17	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.17	Consensus	go_class-b1	Orthosteric Ligand	go_crf
4.17	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.17	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.00	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
4.00	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
4.00	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.00	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
4.00	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.00	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.00	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
4.00	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.00	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
4.00	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
4.00	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
4.00	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
4.00	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
4.00	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
4.00	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.00	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.00	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.00	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
4.00	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
4.00	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
4.00	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.00	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
3.85	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
3.85	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
3.85	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
3.85	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
3.85	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
3.85	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
3.85	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
3.85	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
3.85	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
3.85	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
3.85	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
3.85	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
3.85	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
3.70	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.70	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
3.70	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.70	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.70	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.70	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.70	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
3.70	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
3.57	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
3.57	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.57	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.57	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.57	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.57	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.57	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.57	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
3.45	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.45	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.45	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.45	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.45	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.45	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.45	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.45	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.45	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.45	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.45	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.45	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
3.45	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.33	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.33	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.33	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
3.33	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
3.23	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.23	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.12	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.12	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
3.12	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.03	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
3.03	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
3.03	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
2.94	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.94	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
2.94	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.86	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.86	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.78	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:R67	S:S:R70	5.33	1	Yes	No	4	5	1	2
S:S:R67	S:S:W71	7	1	Yes	Yes	4	4	1	1
S:S:R67	S:S:S302	3.95	1	Yes	No	4	5	1	2
S:S:R67	X:X:W1108	3	1	Yes	Yes	4	0	1	0
S:S:G68	S:S:W71	5.63	0	No	Yes	6	4	2	1
S:S:R70	S:S:S417	6.59	0	No	Yes	5	7	2	2
S:S:T146	S:S:W71	3.64	1	Yes	Yes	4	4	2	1
S:S:I416	S:S:W71	14.09	0	No	Yes	6	4	2	1
S:S:S417	S:S:W71	4.94	1	Yes	Yes	7	4	2	1
S:S:W71	X:X:W1108	2.81	1	Yes	Yes	4	0	1	0
S:S:T146	S:S:Y168	12.48	1	Yes	Yes	4	5	2	2
S:S:S148	S:S:Y219	5.09	0	No	Yes	5	8	2	1
S:S:A169	S:S:Y168	2.67	0	No	Yes	7	5	1	2
S:S:A169	X:X:W1108	5.19	0	No	Yes	7	0	1	0
S:S:S171	S:S:Y219	2.54	0	No	Yes	6	8	2	1
S:S:Q194	S:S:S297	5.78	5	Yes	No	6	7	2	2
S:S:E298	S:S:Q194	5.1	0	No	Yes	6	6	1	2
S:S:D217	S:S:Y219	3.45	0	No	Yes	6	8	2	1
S:S:S297	S:S:Y219	5.09	0	No	Yes	7	8	2	1
S:S:A299	S:S:Y219	4	1	No	Yes	7	8	1	1
S:S:Y219	X:X:W1108	3.86	1	Yes	Yes	8	0	1	0
S:S:G274	S:S:S303	3.71	1	No	No	1	1	2	2
M:M:?1103	S:S:G274	3.14	1	No	No	0	1	1	2
S:S:E298	S:S:L323	5.3	0	No	No	6	4	1	2
S:S:E298	X:X:W1108	5.45	0	No	Yes	6	0	1	0
S:S:A299	X:X:W1108	6.48	1	No	Yes	7	0	1	0
M:M:?1103	S:S:S303	5.51	1	No	No	0	1	1	2
M:M:?1103	X:X:W1108	4.18	1	No	Yes	0	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
100.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
100.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
100.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
50.00	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
50.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
50.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
50.00	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
50.00	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
50.00	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
50.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
50.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
50.00	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
50.00	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
50.00	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
50.00	Single	7DD5	Ca3	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
50.00	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
50.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
50.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
50.00	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
50.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
50.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
50.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
50.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
50.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
50.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
50.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
50.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
50.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
50.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
50.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
50.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
50.00	Single	7EB2	Baclofen	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
50.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
50.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
50.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
50.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
50.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
50.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
50.00	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
50.00	Single	7FII	hCG	7FII-LH-hCG-6fuf
50.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
50.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
50.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
50.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
50.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
50.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
50.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
50.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
50.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
50.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
50.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
50.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
50.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
50.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
50.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
50.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
50.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
50.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
50.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
50.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
50.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
50.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
50.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
50.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
50.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
50.00	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
50.00	Single	7XW7	K1-70	7XW7-TSH-K1-70
50.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
50.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
50.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
50.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
50.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
50.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
50.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
50.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
50.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
50.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
50.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
50.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
50.00	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-J9R
50.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
50.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
50.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
50.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
50.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
50.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
50.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
50.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
50.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
50.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
50.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
50.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
50.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
50.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
50.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
50.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
50.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
50.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
50.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
50.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
50.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
50.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
50.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
50.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
50.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
50.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
50.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
50.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
50.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
50.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
50.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
50.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
50.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
50.00	Consensus	fsh_on_allo	Orthosteric Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
50.00	Consensus	gabab_off	Orthosteric Ligand	7C7S-GABA_B1, GABA_B2-CGP54626 7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid 6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
50.00	Consensus	gabab_on	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
50.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
50.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
50.00	Consensus	gi_gaba	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
50.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
50.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
50.00	Consensus	gphr_on	Orthosteric Ligand	lh_on tsh_on
50.00	Consensus	gs_gphr	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
50.00	Consensus	gs_protein	Orthosteric Ligand	gs_gphr
50.00	Consensus	lh_on	Orthosteric Ligand	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
50.00	Consensus	lh_on_allo	Orthosteric Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
50.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
50.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
50.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
50.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
50.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
50.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
50.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
50.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
50.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
50.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
50.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
50.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
50.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
50.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
50.00	Consensus	smo_off_allo	Other Ligand	6D32-SMO-Cyclopamine-Cyclopamine
50.00	Consensus	tsh_on	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2
50.00	Consensus	tsh_on_allo	Orthosteric Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
33.33	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
33.33	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
33.33	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
25.00	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
25.00	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
25.00	Single	8HS2	Fab046	8HS2-GPR20-Fab046
20.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
20.00	Single	6W25	Ca	6W25-MC₄-SHU9119-Ca
20.00	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
20.00	Single	7UTZ	TR1402	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
20.00	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
20.00	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
16.67	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
16.67	Single	6VCB	LSN3160440	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
16.67	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/&β;1/&γ;2
16.67	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
16.67	Single	8I2G	Glycoprotein hormones alpha chain	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67	Consensus	glp1_on_allo	Other Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
14.29	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
14.29	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
12.50	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
12.50	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
12.50	Single	6LI0	GTPL9804	6LI0-GPR52-GTPL9804
12.50	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
12.50	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
12.50	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
11.11	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
11.11	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
11.11	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
11.11	Consensus	go_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Consensus	go_protein	Orthosteric Ligand	go_chemokine
11.11	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
10.00	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
10.00	Single	5U09	Taranabant	5U09-CB₁-Taranabant
10.00	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
10.00	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
10.00	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.00	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
10.00	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
10.00	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
10.00	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
10.00	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
10.00	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
10.00	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
10.00	Single	8HMP	PubChem 69921479	8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
10.00	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.00	Consensus	class-f_off	Orthosteric Ligand	smo_off
10.00	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
10.00	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
10.00	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
9.09	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
9.09	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.09	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
9.09	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
9.09	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
9.09	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
9.09	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
9.09	Single	8DWG	ML382	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
9.09	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
9.09	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
9.09	Consensus	gi_class-f	Orthosteric Ligand	gi_frizzled
9.09	Consensus	gi_frizzled	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.09	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
9.09	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
9.09	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
8.33	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
8.33	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
8.33	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
8.33	Single	6D27	CAY10471	6D27-DP₂-CAY10471
8.33	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
8.33	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
8.33	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
8.33	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
8.33	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
8.33	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
8.33	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
8.33	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
8.33	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
8.33	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
8.33	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
8.33	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
8.33	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
8.33	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
8.33	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
8.33	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
8.33	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
7.69	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
7.69	Single	5C1M	BU72	5C1M-μ-BU72
7.69	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
7.69	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
7.69	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
7.69	Single	7C4S	S1P	7C4S-S1P₃-S1P
7.69	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
7.69	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
7.69	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
7.69	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
7.69	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
7.69	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
7.69	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
7.14	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
7.14	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
7.14	Single	5V56	TC114	5V56-SMO-TC114
7.14	Single	5V57	TC114	5V57-SMO-TC114
7.14	Single	6OS1	TRV026	6OS1-AT₁-TRV026
7.14	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
7.14	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
7.14	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
7.14	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.14	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.14	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.14	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
7.14	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
7.14	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
7.14	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.14	Single	8E0G	BU72	8E0G-μ-BU72
7.14	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
7.14	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.14	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
7.14	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
7.14	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.14	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
7.14	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.14	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
7.14	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
7.14	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.14	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
6.67	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
6.67	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
6.67	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
6.67	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
6.67	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
6.67	Single	6OS2	TRV026	6OS2-AT₁-TRV026
6.67	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.67	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
6.67	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
6.67	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
6.67	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
6.67	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
6.67	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
6.67	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.67	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
6.67	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
6.67	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
6.67	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
6.67	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
6.67	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
6.67	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
6.67	Consensus	dp_off	Orthosteric Ligand	dp2_off
6.67	Consensus	gi_class-f	Other Ligand	gi_frizzled
6.67	Consensus	gi_frizzled	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.67	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
6.67	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
6.67	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Consensus	nts_on	Orthosteric Ligand	nts1_on
6.67	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
6.67	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.25	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
6.25	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
6.25	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
6.25	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
6.25	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.25	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
6.25	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
6.25	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6.25	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
6.25	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
6.25	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
6.25	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
6.25	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.25	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.25	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.25	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
5.88	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
5.88	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
5.88	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
5.88	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.88	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
5.88	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
5.88	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
5.88	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.88	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
5.88	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
5.88	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
5.88	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
5.88	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
5.88	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
5.56	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
5.56	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.56	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.56	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
5.56	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
5.56	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
5.56	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.56	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
5.56	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.56	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.56	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.56	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
5.56	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.56	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.56	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.56	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
5.56	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
5.26	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
5.26	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.26	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
5.26	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
5.26	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
5.26	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
5.26	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
5.26	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.26	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
5.26	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.26	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.26	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
5.26	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
5.00	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
5.00	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
5.00	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
5.00	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
5.00	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
5.00	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.00	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.00	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
5.00	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
5.00	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.00	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
5.00	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
5.00	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
5.00	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
5.00	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
4.76	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
4.76	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
4.76	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
4.76	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.76	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.76	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
4.76	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
4.76	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.76	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
4.76	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.76	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
4.76	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
4.76	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
4.76	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.76	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.76	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
4.76	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
4.76	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
4.76	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
4.76	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
4.76	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.55	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.55	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
4.55	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.55	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.55	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.55	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.55	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.55	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.55	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.55	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.55	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.55	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
4.55	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
4.55	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.55	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.55	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
4.55	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
4.35	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
4.35	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
4.35	Single	6FJ3	PTH	6FJ3-PTH1-PTH
4.35	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.35	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.35	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.35	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.35	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
4.35	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
4.35	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
4.35	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.35	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
4.35	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
4.35	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.35	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.35	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
4.35	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.35	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.17	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
4.17	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
4.17	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
4.17	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.17	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
4.17	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
4.17	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
4.17	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.17	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.17	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.17	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
4.17	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.17	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
4.17	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
4.17	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.17	Consensus	go_class-b1	Orthosteric Ligand	go_crf
4.17	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.17	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.00	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
4.00	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
4.00	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.00	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
4.00	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.00	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.00	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
4.00	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.00	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
4.00	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
4.00	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
4.00	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
4.00	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
4.00	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
4.00	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.00	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.00	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.00	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
4.00	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
4.00	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
4.00	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.00	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
3.85	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
3.85	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
3.85	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
3.85	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
3.85	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
3.85	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
3.85	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
3.85	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
3.85	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
3.85	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
3.85	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
3.85	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
3.85	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
3.70	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.70	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
3.70	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.70	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.70	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.70	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.70	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
3.70	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
3.57	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
3.57	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.57	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.57	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.57	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.57	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.57	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.57	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
3.45	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.45	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.45	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.45	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.45	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.45	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.45	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.45	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.45	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.45	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.45	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.45	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
3.45	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.33	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.33	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.33	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
3.33	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
3.23	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.23	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.12	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.12	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
3.12	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.03	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
3.03	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
3.03	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
2.94	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.94	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
2.94	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.86	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.86	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.78	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F43	R:R:P275	5.78	2	Yes	Yes	3	4	2	1
R:R:F43	R:R:L305	8.53	2	Yes	No	3	4	2	2
R:R:A169	W:W:W1108	3.89	2	No	Yes	7	0	2	1
R:R:A299	R:R:Y219	4	2	No	Yes	7	8	2	2
R:R:Y219	W:W:W1108	3.86	2	Yes	Yes	8	0	2	1
R:R:G274	R:R:S273	3.71	2	Yes	No	1	4	1	2
R:R:P275	R:R:S273	5.34	2	Yes	No	4	4	1	2
R:R:G274	R:R:P275	4.06	2	Yes	Yes	1	4	1	1
R:R:G274	R:R:S303	3.71	2	Yes	No	1	3	1	1
L:L:?1103	R:R:G274	3.14	2	Yes	Yes	0	1	0	1
R:R:L305	R:R:P275	4.93	2	No	Yes	4	4	2	1
L:L:?1103	R:R:P275	3.02	2	Yes	Yes	0	4	0	1
R:R:E298	W:W:W1108	5.45	0	No	Yes	6	0	2	1
R:R:A299	W:W:W1108	3.89	2	No	Yes	7	0	2	1
R:R:L305	R:R:S303	3	2	No	No	4	3	2	1
L:L:?1103	R:R:S303	5.51	2	Yes	No	0	3	0	1
L:L:?1103	W:W:W1108	4.18	2	Yes	Yes	0	0	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
100.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
100.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
100.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
50.00	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
50.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
50.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
50.00	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
50.00	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
50.00	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
50.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
50.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
50.00	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
50.00	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
50.00	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
50.00	Single	7DD5	Ca3	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
50.00	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
50.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
50.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
50.00	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
50.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
50.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
50.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
50.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
50.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
50.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
50.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
50.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
50.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
50.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
50.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
50.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
50.00	Single	7EB2	Baclofen	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
50.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
50.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
50.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
50.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
50.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
50.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
50.00	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
50.00	Single	7FII	hCG	7FII-LH-hCG-6fuf
50.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
50.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
50.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
50.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
50.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
50.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
50.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
50.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
50.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
50.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
50.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
50.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
50.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
50.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
50.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
50.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
50.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
50.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
50.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
50.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
50.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
50.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
50.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
50.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
50.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
50.00	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
50.00	Single	7XW7	K1-70	7XW7-TSH-K1-70
50.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
50.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
50.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
50.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
50.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
50.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
50.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
50.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
50.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
50.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
50.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
50.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
50.00	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-J9R
50.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
50.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
50.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
50.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
50.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
50.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
50.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
50.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
50.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
50.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
50.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
50.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
50.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
50.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
50.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
50.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
50.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
50.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
50.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
50.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
50.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
50.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
50.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
50.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
50.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
50.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
50.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
50.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
50.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
50.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
50.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
50.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
50.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
50.00	Consensus	fsh_on_allo	Orthosteric Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
50.00	Consensus	gabab_off	Orthosteric Ligand	7C7S-GABA_B1, GABA_B2-CGP54626 7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid 6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
50.00	Consensus	gabab_on	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
50.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
50.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
50.00	Consensus	gi_gaba	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
50.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
50.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
50.00	Consensus	gphr_on	Orthosteric Ligand	lh_on tsh_on
50.00	Consensus	gs_gphr	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
50.00	Consensus	gs_protein	Orthosteric Ligand	gs_gphr
50.00	Consensus	lh_on	Orthosteric Ligand	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
50.00	Consensus	lh_on_allo	Orthosteric Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
50.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
50.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
50.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
50.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
50.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
50.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
50.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
50.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
50.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
50.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
50.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
50.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
50.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
50.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
50.00	Consensus	smo_off_allo	Other Ligand	6D32-SMO-Cyclopamine-Cyclopamine
50.00	Consensus	tsh_on	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2
50.00	Consensus	tsh_on_allo	Orthosteric Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
33.33	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
33.33	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
33.33	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
25.00	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
25.00	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
25.00	Single	8HS2	Fab046	8HS2-GPR20-Fab046
20.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
20.00	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
20.00	Single	7UTZ	TR1402	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
20.00	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
20.00	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
16.67	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
16.67	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/&β;1/&γ;2
16.67	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
16.67	Single	8I2G	Glycoprotein hormones alpha chain	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
14.29	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
14.29	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
12.50	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
12.50	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
12.50	Single	6LI0	GTPL9804	6LI0-GPR52-GTPL9804
12.50	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
12.50	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
12.50	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
11.11	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
11.11	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
11.11	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
11.11	Consensus	go_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Consensus	go_protein	Orthosteric Ligand	go_chemokine
11.11	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
10.00	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
10.00	Single	5U09	Taranabant	5U09-CB₁-Taranabant
10.00	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
10.00	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
10.00	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.00	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
10.00	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
10.00	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
10.00	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
10.00	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
10.00	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
10.00	Single	8HMP	PubChem 69921479	8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
10.00	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.00	Consensus	class-f_off	Orthosteric Ligand	smo_off
10.00	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
10.00	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
10.00	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
9.09	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
9.09	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.09	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
9.09	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
9.09	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
9.09	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
9.09	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
9.09	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
9.09	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
9.09	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
9.09	Consensus	gi_class-f	Orthosteric Ligand	gi_frizzled
9.09	Consensus	gi_frizzled	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.09	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
9.09	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
9.09	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
8.33	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
8.33	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
8.33	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
8.33	Single	6D27	CAY10471	6D27-DP₂-CAY10471
8.33	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
8.33	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
8.33	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
8.33	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
8.33	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
8.33	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
8.33	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
8.33	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
8.33	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
8.33	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
8.33	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
8.33	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
8.33	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
8.33	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
8.33	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
8.33	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
8.33	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
7.69	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
7.69	Single	5C1M	BU72	5C1M-μ-BU72
7.69	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
7.69	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
7.69	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
7.69	Single	7C4S	S1P	7C4S-S1P₃-S1P
7.69	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
7.69	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
7.69	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
7.69	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
7.69	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
7.69	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
7.69	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
7.14	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
7.14	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
7.14	Single	5V56	TC114	5V56-SMO-TC114
7.14	Single	5V57	TC114	5V57-SMO-TC114
7.14	Single	6OS1	TRV026	6OS1-AT₁-TRV026
7.14	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
7.14	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
7.14	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
7.14	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.14	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.14	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.14	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
7.14	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
7.14	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
7.14	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.14	Single	8E0G	BU72	8E0G-μ-BU72
7.14	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
7.14	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.14	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
7.14	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
7.14	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.14	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
7.14	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.14	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
7.14	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
7.14	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.14	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
6.67	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
6.67	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
6.67	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
6.67	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
6.67	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
6.67	Single	6OS2	TRV026	6OS2-AT₁-TRV026
6.67	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
6.67	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
6.67	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
6.67	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
6.67	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
6.67	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
6.67	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.67	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
6.67	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
6.67	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
6.67	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
6.67	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
6.67	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
6.67	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
6.67	Consensus	dp_off	Orthosteric Ligand	dp2_off
6.67	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
6.67	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
6.67	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Consensus	nts_on	Orthosteric Ligand	nts1_on
6.67	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
6.67	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.25	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
6.25	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
6.25	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
6.25	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
6.25	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.25	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
6.25	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
6.25	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6.25	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
6.25	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
6.25	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
6.25	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
6.25	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.25	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.25	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.25	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
5.88	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
5.88	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
5.88	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
5.88	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.88	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
5.88	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
5.88	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
5.88	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.88	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
5.88	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
5.88	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
5.88	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
5.88	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
5.88	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
5.56	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
5.56	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.56	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.56	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
5.56	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
5.56	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
5.56	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.56	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
5.56	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.56	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.56	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.56	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
5.56	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.56	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.56	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.56	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
5.56	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
5.26	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
5.26	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.26	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
5.26	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
5.26	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
5.26	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
5.26	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
5.26	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.26	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
5.26	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.26	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.26	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
5.26	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
5.00	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
5.00	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
5.00	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
5.00	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
5.00	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
5.00	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.00	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.00	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
5.00	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
5.00	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.00	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
5.00	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
5.00	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
5.00	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
5.00	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
4.76	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
4.76	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
4.76	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
4.76	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.76	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.76	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
4.76	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
4.76	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.76	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
4.76	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.76	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
4.76	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
4.76	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
4.76	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.76	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.76	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
4.76	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
4.76	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
4.76	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
4.76	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
4.76	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.55	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.55	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
4.55	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.55	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.55	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.55	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.55	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.55	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.55	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.55	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.55	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.55	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
4.55	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
4.55	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.55	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.55	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
4.55	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
4.35	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
4.35	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
4.35	Single	6FJ3	PTH	6FJ3-PTH1-PTH
4.35	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.35	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.35	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.35	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.35	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
4.35	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
4.35	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
4.35	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.35	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
4.35	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
4.35	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.35	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.35	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
4.35	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.35	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.17	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
4.17	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
4.17	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
4.17	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.17	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
4.17	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
4.17	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
4.17	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.17	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.17	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.17	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
4.17	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.17	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
4.17	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
4.17	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.17	Consensus	go_class-b1	Orthosteric Ligand	go_crf
4.17	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.17	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.00	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
4.00	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
4.00	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.00	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
4.00	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.00	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.00	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
4.00	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.00	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
4.00	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
4.00	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
4.00	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
4.00	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
4.00	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
4.00	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.00	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.00	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.00	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
4.00	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
4.00	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
4.00	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.00	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
3.85	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
3.85	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
3.85	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
3.85	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
3.85	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
3.85	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
3.85	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
3.85	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
3.85	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
3.85	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
3.85	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
3.85	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
3.85	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
3.70	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.70	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
3.70	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.70	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.70	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.70	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.70	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
3.70	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
3.57	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
3.57	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.57	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.57	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.57	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.57	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.57	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.57	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
3.45	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.45	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.45	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.45	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.45	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.45	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.45	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.45	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.45	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.45	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.45	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.45	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
3.45	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.33	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.33	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.33	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
3.33	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
3.23	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.23	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.12	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.12	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
3.12	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.03	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
3.03	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
3.03	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
2.94	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.94	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
2.94	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.86	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.86	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.78	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:T146	R:R:Y168	6.24	2	Yes	Yes	3	5	2	2
R:R:A169	R:R:T146	3.36	2	No	Yes	7	3	1	2
R:R:S148	R:R:Y219	5.09	0	No	Yes	5	8	2	1
R:R:A169	R:R:Y168	2.67	2	No	Yes	7	5	1	2
R:R:A169	W:W:W1108	3.89	2	No	Yes	7	0	1	0
R:R:D191	R:R:S171	10.31	2	No	No	3	7	2	2
R:R:S171	R:R:Y219	2.54	2	No	Yes	7	8	2	1
R:R:D191	R:R:Q194	6.53	2	No	Yes	3	6	2	2
R:R:D191	R:R:Y219	5.75	2	No	Yes	3	8	2	1
R:R:E298	R:R:Q194	5.1	0	No	Yes	6	6	1	2
R:R:G220	R:R:Y219	2.9	0	No	Yes	5	8	2	1
R:R:S297	R:R:Y219	5.09	0	No	Yes	8	8	2	1
R:R:A299	R:R:Y219	4	2	No	Yes	7	8	1	1
R:R:Y219	W:W:W1108	3.86	2	Yes	Yes	8	0	1	0
R:R:G274	R:R:P275	4.06	2	Yes	Yes	1	4	2	2
R:R:G274	R:R:S303	3.71	2	Yes	No	1	3	2	2
L:L:?1103	R:R:G274	3.14	2	Yes	Yes	0	1	1	2
L:L:?1103	R:R:P275	3.02	2	Yes	Yes	0	4	1	2
R:R:E298	R:R:L323	6.63	0	No	No	6	5	1	2
R:R:E298	W:W:W1108	5.45	0	No	Yes	6	0	1	0
R:R:A299	W:W:W1108	3.89	2	No	Yes	7	0	1	0
L:L:?1103	R:R:S303	5.51	2	Yes	No	0	3	1	2
L:L:?1103	W:W:W1108	4.18	2	Yes	Yes	0	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
100.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
100.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
100.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
50.00	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
50.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
50.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
50.00	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
50.00	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
50.00	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
50.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
50.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
50.00	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
50.00	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
50.00	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
50.00	Single	7DD5	Ca3	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
50.00	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
50.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
50.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
50.00	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
50.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
50.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
50.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
50.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
50.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
50.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
50.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
50.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
50.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
50.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
50.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
50.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
50.00	Single	7EB2	Baclofen	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
50.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
50.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
50.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
50.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
50.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
50.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
50.00	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
50.00	Single	7FII	hCG	7FII-LH-hCG-6fuf
50.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
50.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
50.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
50.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
50.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
50.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
50.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
50.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
50.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
50.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
50.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
50.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
50.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
50.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
50.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
50.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
50.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
50.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
50.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
50.00	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
50.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
50.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
50.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
50.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
50.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
50.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
50.00	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
50.00	Single	7XW7	K1-70	7XW7-TSH-K1-70
50.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
50.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
50.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
50.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
50.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
50.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
50.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
50.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
50.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
50.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
50.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
50.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
50.00	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-J9R
50.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
50.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
50.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
50.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
50.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
50.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
50.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
50.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
50.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
50.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
50.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
50.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
50.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
50.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
50.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
50.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
50.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
50.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
50.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
50.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
50.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
50.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
50.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
50.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
50.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
50.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
50.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
50.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
50.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
50.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
50.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
50.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
50.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
50.00	Consensus	fsh_on_allo	Orthosteric Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
50.00	Consensus	gabab_off	Orthosteric Ligand	7C7S-GABA_B1, GABA_B2-CGP54626 7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid 6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
50.00	Consensus	gabab_on	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
50.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
50.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
50.00	Consensus	gi_gaba	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
50.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
50.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
50.00	Consensus	gphr_on	Orthosteric Ligand	lh_on tsh_on
50.00	Consensus	gs_gphr	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
50.00	Consensus	gs_protein	Orthosteric Ligand	gs_gphr
50.00	Consensus	lh_on	Orthosteric Ligand	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
50.00	Consensus	lh_on_allo	Orthosteric Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
50.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
50.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
50.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
50.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
50.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
50.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
50.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
50.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
50.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
50.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
50.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
50.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
50.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
50.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
50.00	Consensus	smo_off_allo	Other Ligand	6D32-SMO-Cyclopamine-Cyclopamine
50.00	Consensus	tsh_on	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2
50.00	Consensus	tsh_on_allo	Orthosteric Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
33.33	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
33.33	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
33.33	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
25.00	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
25.00	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
25.00	Single	8HS2	Fab046	8HS2-GPR20-Fab046
20.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
20.00	Single	6W25	Ca	6W25-MC₄-SHU9119-Ca
20.00	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
20.00	Single	7UTZ	TR1402	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
20.00	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
20.00	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
16.67	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
16.67	Single	6VCB	LSN3160440	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
16.67	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/&β;1/&γ;2
16.67	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
16.67	Single	8I2G	Glycoprotein hormones alpha chain	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67	Consensus	glp1_on_allo	Other Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
14.29	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
14.29	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
12.50	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
12.50	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
12.50	Single	6LI0	GTPL9804	6LI0-GPR52-GTPL9804
12.50	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
12.50	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
12.50	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
11.11	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
11.11	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
11.11	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
11.11	Consensus	go_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Consensus	go_protein	Orthosteric Ligand	go_chemokine
11.11	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
10.00	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
10.00	Single	5U09	Taranabant	5U09-CB₁-Taranabant
10.00	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
10.00	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
10.00	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.00	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
10.00	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
10.00	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
10.00	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
10.00	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
10.00	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
10.00	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
10.00	Single	8HMP	PubChem 69921479	8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
10.00	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.00	Consensus	class-f_off	Orthosteric Ligand	smo_off
10.00	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
10.00	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
10.00	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
9.09	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
9.09	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.09	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
9.09	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
9.09	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
9.09	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
9.09	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
9.09	Single	8DWG	ML382	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
9.09	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
9.09	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
9.09	Consensus	gi_class-f	Orthosteric Ligand	gi_frizzled
9.09	Consensus	gi_frizzled	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.09	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
9.09	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
9.09	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
8.33	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
8.33	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
8.33	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
8.33	Single	6D27	CAY10471	6D27-DP₂-CAY10471
8.33	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
8.33	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
8.33	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
8.33	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
8.33	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
8.33	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
8.33	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
8.33	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
8.33	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
8.33	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
8.33	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
8.33	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
8.33	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
8.33	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
8.33	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
8.33	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
8.33	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
7.69	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
7.69	Single	5C1M	BU72	5C1M-μ-BU72
7.69	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
7.69	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
7.69	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
7.69	Single	7C4S	S1P	7C4S-S1P₃-S1P
7.69	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
7.69	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
7.69	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
7.69	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
7.69	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
7.69	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
7.69	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
7.14	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
7.14	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
7.14	Single	5V56	TC114	5V56-SMO-TC114
7.14	Single	5V57	TC114	5V57-SMO-TC114
7.14	Single	6OS1	TRV026	6OS1-AT₁-TRV026
7.14	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
7.14	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
7.14	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
7.14	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.14	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.14	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.14	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
7.14	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
7.14	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
7.14	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.14	Single	8E0G	BU72	8E0G-μ-BU72
7.14	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
7.14	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.14	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
7.14	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
7.14	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.14	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
7.14	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.14	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
7.14	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
7.14	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.14	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
6.67	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
6.67	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
6.67	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
6.67	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
6.67	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
6.67	Single	6OS2	TRV026	6OS2-AT₁-TRV026
6.67	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.67	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
6.67	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
6.67	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
6.67	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
6.67	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
6.67	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
6.67	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.67	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
6.67	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
6.67	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
6.67	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
6.67	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
6.67	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
6.67	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
6.67	Consensus	dp_off	Orthosteric Ligand	dp2_off
6.67	Consensus	gi_class-f	Other Ligand	gi_frizzled
6.67	Consensus	gi_frizzled	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.67	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
6.67	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
6.67	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Consensus	nts_on	Orthosteric Ligand	nts1_on
6.67	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
6.67	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.25	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
6.25	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
6.25	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
6.25	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
6.25	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.25	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
6.25	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
6.25	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6.25	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
6.25	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
6.25	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
6.25	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
6.25	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.25	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.25	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.25	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
5.88	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
5.88	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
5.88	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
5.88	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.88	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
5.88	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
5.88	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
5.88	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.88	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
5.88	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
5.88	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
5.88	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
5.88	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
5.88	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
5.56	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
5.56	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.56	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.56	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
5.56	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
5.56	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
5.56	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.56	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
5.56	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.56	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.56	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.56	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
5.56	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.56	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.56	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.56	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
5.56	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
5.26	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
5.26	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.26	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
5.26	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
5.26	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
5.26	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
5.26	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
5.26	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.26	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
5.26	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.26	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.26	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
5.26	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
5.00	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
5.00	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
5.00	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
5.00	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
5.00	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
5.00	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.00	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.00	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
5.00	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
5.00	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.00	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
5.00	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
5.00	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
5.00	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
5.00	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
4.76	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
4.76	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
4.76	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
4.76	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.76	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.76	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
4.76	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
4.76	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.76	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
4.76	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.76	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
4.76	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
4.76	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
4.76	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.76	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.76	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
4.76	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
4.76	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
4.76	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
4.76	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
4.76	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.55	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.55	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
4.55	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.55	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.55	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.55	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.55	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.55	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.55	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.55	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.55	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.55	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
4.55	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
4.55	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.55	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.55	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
4.55	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
4.35	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
4.35	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
4.35	Single	6FJ3	PTH	6FJ3-PTH1-PTH
4.35	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.35	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.35	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.35	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.35	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
4.35	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
4.35	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
4.35	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.35	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
4.35	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
4.35	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.35	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.35	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
4.35	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.35	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.17	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
4.17	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
4.17	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
4.17	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.17	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
4.17	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
4.17	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
4.17	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.17	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.17	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.17	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
4.17	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.17	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
4.17	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
4.17	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.17	Consensus	go_class-b1	Orthosteric Ligand	go_crf
4.17	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.17	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.00	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
4.00	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
4.00	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.00	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
4.00	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.00	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.00	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
4.00	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.00	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
4.00	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
4.00	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
4.00	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
4.00	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
4.00	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
4.00	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.00	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.00	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.00	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
4.00	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
4.00	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
4.00	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.00	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
3.85	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
3.85	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
3.85	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
3.85	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
3.85	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
3.85	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
3.85	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
3.85	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
3.85	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
3.85	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
3.85	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
3.85	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
3.85	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
3.70	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.70	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
3.70	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.70	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.70	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.70	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.70	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
3.70	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
3.57	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
3.57	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.57	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.57	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.57	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.57	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.57	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.57	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
3.45	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.45	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.45	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.45	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.45	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.45	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.45	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.45	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.45	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.45	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.45	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.45	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
3.45	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.33	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.33	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.33	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
3.33	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
3.23	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.23	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.12	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.12	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
3.12	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.03	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
3.03	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
3.03	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
2.94	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.94	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
2.94	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.86	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.86	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.78	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB	7DD6
Class	C
SubFamily	Ion
Type	Calcium-sensing
SubType	CaS
Species	Gallus gallus
Ligand	Ca
Other Ligand(s)	Ca; Ca; Tryptophan
Protein Partners	-
PDB Resolution	3.2
Date	2021-06-16
D.O.I.	10.1126/sciadv.abg1483

Net Summary
I_min	2.51
Number of Linked Nodes	1545
Number of Links	1914
Number of Hubs	304
Number of Links mediated by Hubs	1103
Number of Communities	62
Number of Nodes involved in Communities	512
Number of Links involved in Communities	743

Path Summary
Number Of Nodes in MetaPath	179
Number Of Links MetaPath	178
Number of Shortest Paths	5820884
Length Of Smallest Path	3
Average Path Length	38.8765
Length of Longest Path	83
Minimum Path Strength	1.105
Average Path Strength	5.40371
Maximum Path Strength	32.685
Minimum Path Correlation	0.7
Average Path Correlation	0.998554
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	1.63934
Average % Of Corr. Nodes	62.5645
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.4407
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CA
PDB Residues	I:I:?1102 L:L:?1103 I:I:?1104 I:I:?1105 M:M:?1103 I:I:?1106
Environment Details	Open EMBL-EBI Page
Code	CA
Name	CALCIUM ION
Synonyms
Identifier	calcium(+2) cation
Formula	Ca
Molecular Weight	40.078
SMILES	[Ca+2]
PubChem
Formal Charge	2
Total Atoms	1
Total Chiral Atoms	0
Total Bonds	0
Total Aromatic Bonds	0


Code	NAG
PDB Residues	H:H:?1 H:H:?2 H:H:?3 H:H:?4 H:H:?5 H:H:?6 H:H:?7 H:H:?8 H:H:?9 H:H:?10 H:H:?11 H:H:?12 H:H:?13 H:H:?14
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetyl-D-glucosamine
Identifier	N-[(2R,3R,4R,5S,6R)-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl]ethanamide
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES	CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	XP_040517477
Sequence	>7DD6_Chain_R Y G P N Q R A Q K K G D I I L G G L F P I H F G V A A K D Q D L K S R P E S V E C I R Y N F R G F R W L Q A M I F A I E E I N N S P N L L P N M T L G Y R I F D T C N T V S K A L E A T L S F V A Q N K H I P S T I A V V G A T G S G V S T A V A N L L G L F Y I P Q V S Y A S S S R L L S N K N Q F K S F L R T I P N D E H Q A T A M A D I I E Y F R W N W V G T I A A D D D Y G R P G I E K F R E E A E E R D I C I D F S E L I S Q Y S D E E E I Q Q V V E V I Q N S T A R V I V V F S S G P D L E P L I K E I V R R N I T G K I W L A S E A W A S S S L I A M P E F F R V I G S T I G F A L K A G Q I P G F R E F L Q K V H P K K S A N N G F A K E F W E E T F N C Y P P C T G D E N I T S V E T P Y M D F T H L R I S Y N V Y L A V Y S I A H A L Q D I Y T C T P G K G L F T N G S C A D I K K V E A W Q V L K H L R H L N F T S N M G E Q V D F D E F G D L V G N Y S I I N W H L S P E D G S V V F E E V G H Y N V Y A K K G E R L F I N E N K I L W S G F S K E V P F S N C S R D C L P G T R K G I I E G E P T C C F E C V D C P D G E Y S D E T D A S A C D K C P E D Y W S N E N H T S C I P K Q I E F L S W T E P F G I A L T L F A V L G I F L T S F V L G V F T K F R N T P I V K A T N R E L S Y L L L F S L L C C F S S S L F F I G E P Q N W T C R L R Q P A F G I S F V L C I S C I L V K T N R V L L V F E W G L N L Q F L L V F L C T F V Q I V I C V I W L Y T A P P S S Y R N H E L E D E I I F I T C H E G S L M A L G F L I G Y T C L L A A I C F F F A F K S R K L P E N F N E A K F I T F S M L I F F I V W I S F I P A Y A S T Y G K F V S A V E V I A I L A A S F G L L A C I F F N K V Y I I L F K P S R N T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7DD5	C	Ion	Calcium-sensing	CaS	Gallus gallus	Ca	Ca; Ca; Tryptophan; NPS-2143	-	3.2	2021-06-16	10.1126/sciadv.abg1483
	7DD6	C	Ion	Calcium-sensing	CaS	Gallus gallus	Ca	Ca; Ca; Tryptophan	-	3.2	2021-06-16	10.1126/sciadv.abg1483
	7DD7	C	Ion	Calcium-sensing	CaS	Gallus gallus	Ca	Ca; Ca; Tryptophan; Evocalcet	-	3.2	2021-06-16	10.1126/sciadv.abg1483
	7DTT	C	Ion	Calcium-sensing	CaS	Homo sapiens	Ca	Ca	-	3.8	2021-03-10	10.1038/s41422-021-00474-0
	7DTU	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Tryptophan	-	4.4	2021-03-10	10.1038/s41422-021-00474-0
	7DTV	C	Ion	Calcium-sensing	CaS	Homo sapiens	Ca	Ca; Tryptophan	-	3.5	2021-03-10	10.1038/s41422-021-00474-0
	7DTW	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	-	-	4.5	2021-03-10	10.1038/s41422-021-00474-0
	7E6T	C	Ion	Calcium-sensing	CaS	Homo sapiens	Ca	Ca; Ca; Cyclomethyltryptophan; PO4	-	3	2021-09-22	10.7554/eLife.68578
	7E6U	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	-	-	6	2021-09-22	10.7554/eLife.68578
	7M3E	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; NPS-2143; PO4	-	3.2	2021-06-30	10.1038/s41586-021-03691-0
	7M3F	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4	-	2.8	2021-06-30	10.1038/s41586-021-03691-0
	7M3G	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	-	2.5	2021-06-30	10.1038/s41586-021-03691-0
	7M3J	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	NPS-2143; PO4	-	4.1	2021-06-30	10.1038/s41586-021-03691-0
	7SIL	C	Ion	Calcium-sensing	CaS	Homo sapiens	Ca	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	-	2.7	2022-01-19	10.1073/pnas.2115849118
	7SIM	C	Ion	Calcium-sensing	CaS	Homo sapiens	Ca	Ca; Ca; Cyclomethyltryptophan; PO4	-	2.7	2022-01-19	10.1073/pnas.2115849118
	7SIN	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	NPS-2143	-	5.9	2022-01-19	10.1073/pnas.2115849118
	8SZF	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	-	2.8	2024-02-07	10.1038/s41586-024-07055-2
	8SZG	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	chim(NtGi1-Gq)/&β;1/&γ;2	3.6	2024-02-07	10.1038/s41586-024-07055-2
	8SZH	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	Gi1/&β;1/&γ;2	3.1	2024-02-07	10.1038/s41586-024-07055-2
	8SZI	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	Gi3/&β;1/&γ;2	3.5	2024-02-07	10.1038/s41586-024-07055-2
	8WPG	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Tryptophan; Cinacalcet; PO4; Ca	-	2.7	2023-11-22	10.1038/s41422-023-00892-2
	8WPU	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Tryptophan; Cinacalcet; PO4; Ca	chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2	3.1	2023-11-22	10.1038/s41422-023-00892-2
	9AXF	C	Ion	Calcium-sensing	CaS	Homo sapiens	Ca	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	chim(NtGi1-Gs-CtGq)/&β;1/&γ;2	3.5	2024-04-17	10.1038/s41586-024-07331-1
	9AYF	C	Ion	Calcium-sensing	CaS	Homo sapiens	Ca	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	Gi1/&β;1/&γ;2	3.6	2024-04-17	10.1038/s41586-024-07331-1

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