Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1H:H:?1 22.984250
2H:H:?5 22.984260
3H:H:?7 19.694560
4R:R:P22 3.6425415
5R:R:Q24 7.57415
6R:R:G36 4.2275407
7R:R:H41 9.775417
8R:R:V44 4.095412
9R:R:P55 8.21254276
10R:R:Y63 11.012515
11R:R:F65 6.41667612
12R:R:R66 9.536515
13R:R:F68 10.782517
14R:R:W70 10.8275415
15R:R:Q72 7.26167617
16R:R:I81 5.08754109
17R:R:N82 4.7625109
18R:R:L87 5.6854106
19R:R:Y95 8.27254108
20R:R:F98 3.29414
21R:R:K106 5.06667614
22R:R:L112 4.2254205
23R:R:F114 4.7075405
24R:R:N118 7.98754214
25R:R:L125 9.46754394
26R:R:C129 4.5254228
27R:R:I135 4.7425224
28R:R:P163 4.041676178
29R:R:Q164 4.536508
30R:R:S169 5.355408
31R:R:L174 5.81477
32R:R:F183 7.61478
33R:R:R185 4.79333679
34R:R:Q193 8.09754409
35R:R:M197 5.70754497
36R:R:Y203 8.082585
37R:R:F204 15.6825487
38R:R:W206 6.09833689
39R:R:W208 10.547119
40R:R:V209 4.0975488
41R:R:K225 10.455473
42R:R:E229 6.928575
43R:R:D238 10.444118
44R:R:F239 4.931437116
45R:R:I252 3.9325404
46R:R:V266 5.695487
47R:R:F270 6.634407
48R:R:S271 3.82754234
49R:R:P274 5.70254483
50R:R:L276 4.876235
51R:R:E277 9.03754512
52R:R:E282 7.4854296
53R:R:R286 9.7454294
54R:R:Y310 10.315513
55R:R:F320 4.992506
56R:R:I327 9.5675416
57R:R:F330 11.306518
58R:R:F333 14.7417
59R:R:L334 9.514516
60R:R:N345 5.244518
61R:R:F347 8.34857715
62R:R:F351 10.206516
63R:R:W352 10.9985158
64R:R:C395 4.80254159
65R:R:G397 3.7254155
66R:R:E399 9.6054158
67R:R:T406 3.99514
68R:R:Y408 5.4425813
69R:R:I409 5.0875405
70R:R:Y411 11.052515
71R:R:L414 9.79416
72R:R:R415 6.6554525
73R:R:Y418 6.82667617
74R:R:Y421 10.81518
75R:R:Y425 9.125408
76R:R:Y435 6.6045283
77R:R:F444 6.3454303
78R:R:W458 10.27676304
79R:R:Q459 6.2525307
80R:R:L461 3.77754177
81R:R:L464 3.41754177
82R:R:L467 4.79754177
83R:R:N471 7.09516
84R:R:N472 8.62414
85R:R:M473 6.93514
86R:R:N488 12.0554254
87R:R:Y489 5.8125408
88R:R:N493 8.105409
89R:R:W494 10.835147
90R:R:S497 4.2854413
91R:R:F505 7.94144
92R:R:Y511 6.948505
93R:R:V513 5.8354253
94R:R:Y514 8.5165254
95R:R:W530 10.035688
96R:R:V537 9.4325484
97R:R:T550 5.03754566
98R:R:R551 6.85254317
99R:R:E558 6.744115
100R:R:C562 5.734119
101R:R:E572 9.2865317
102R:R:C582 7.434319
103R:R:C585 3.954329
104R:R:F589 5.83254325
105R:R:E649 7.7885187
106R:R:L654 7.24188
107R:R:S657 4.64254189
108R:R:C661 4.195407
109R:R:F662 6.45408
110R:R:P672 5.43754429
111R:R:R678 5.178545
112R:R:R680 10.7875408
113R:R:Q681 11.626549
114R:R:F684 7.99167648
115R:R:I686 5.2254187
116R:R:S687 4.6325406
117R:R:F688 9.34167648
118R:R:L690 3.6775407
119R:R:C691 2.7375408
120R:R:I692 9.4375447
121R:R:T732 8.4525447
122R:R:Q735 9.505449
123R:R:W742 12.684549
124R:R:I761 4.7754577
125R:R:M771 6.0625403
126R:R:F775 9.24167644
127R:R:Y779 12.7683649
128R:R:L783 4.8125449
129R:R:F814 6.26509
130R:R:F815 4.9525407
131R:R:Y825 9.674439
132R:R:E837 9.9175409
133R:R:F853 4.9625409
134S:S:P22 4.825425
135S:S:G36 4.2275407
136S:S:P55 8.544306
137S:S:Y63 11.012525
138S:S:F65 6.41667622
139S:S:R66 9.536525
140S:S:F68 10.566527
141S:S:R69 7.69428
142S:S:W70 10.8275425
143S:S:Q72 10.39427
144S:S:I81 4.37254249
145S:S:N82 4.54754249
146S:S:Y95 7.084588
147S:S:F98 3.29424
148S:S:C101 4.9475428
149S:S:K106 5.06667624
150S:S:F114 4.7075405
151S:S:N118 8.35754204
152S:S:K119 5.51754203
153S:S:D126 5.4525223
154S:S:C129 4.09254228
155S:S:I135 5.5765394
156S:S:F160 9.01254207
157S:S:P163 4.041676388
158S:S:Q164 4.536508
159S:S:S169 5.355408
160S:S:L174 5.81457
161S:S:F183 7.61458
162S:S:R185 5.25667659
163S:S:Q193 8.09754449
164S:S:M197 6.064607
165S:S:Y203 8.67754125
166S:S:F204 15.36254127
167S:S:W206 5.931676129
168S:S:N207 5.8466
169S:S:W208 11.58769
170S:S:V209 4.09754128
171S:S:E229 6.658555
172S:S:D238 10.44468
173S:S:F239 5.125666
174S:S:Q245 9.51404
175S:S:I252 2.9075404
176S:S:Q260 7.8954355
177S:S:V266 5.6954127
178S:S:F270 6.634447
179S:S:S271 4.2054344
180S:S:P274 8.59254593
181S:S:L276 6.0965345
182S:S:E277 9.03754622
183S:S:E282 7.4854356
184S:S:R286 9.7454354
185S:S:K291 5.885496
186S:S:Y310 10.315623
187S:S:F320 4.992506
188S:S:I327 12.0775426
189S:S:F330 8.12857728
190S:S:F333 13.82407
191S:S:L334 8.00833626
192S:S:N345 5.5525428
193S:S:F347 6.90857725
194S:S:F351 10.206526
195S:S:W352 10.9985168
196S:S:E353 6.02754167
197S:S:C395 5.59754169
198S:S:G397 3.7254165
199S:S:E399 9.95754168
200S:S:T406 3.99524
201S:S:Y408 5.30125823
202S:S:I409 5.0875405
203S:S:Y411 9.166525
204S:S:L414 9.18426
205S:S:R415 6.6554635
206S:S:Y418 6.82667627
207S:S:Y421 10.81528
208S:S:Y425 9.125408
209S:S:Y435 6.6045333
210S:S:L443 3.4475403
211S:S:F444 6.65754273
212S:S:W458 8.781676274
213S:S:Q459 7.82754277
214S:S:L461 3.77754387
215S:S:L464 3.41754387
216S:S:N471 7.09526
217S:S:N472 8.62424
218S:S:M473 6.93524
219S:S:Q476 4.624373
220S:S:N488 12.0554264
221S:S:Y489 5.8125408
222S:S:N493 8.4725409
223S:S:W494 10.83597
224S:S:F505 7.9494
225S:S:Y511 6.948505
226S:S:V513 5.8354263
227S:S:Y514 8.5165264
228S:S:I528 4.54754127
229S:S:W530 10.0356128
230S:S:V537 9.1054124
231S:S:P538 5.694128
232S:S:T550 3.97754666
233S:S:E558 6.74465
234S:S:E572 10.0245197
235S:S:C582 6.3854199
236S:S:C585 3.4745139
237S:S:D588 3.91754136
238S:S:E602 8.4054133
239S:S:F605 7.045407
240S:S:E610 6.3956457
241S:S:F634 5.07754469
242S:S:E649 7.1525707
243S:S:L650 5.6754468
244S:S:C661 4.22407
245S:S:F662 8.21254688
246S:S:R680 7.08438
247S:S:Q681 7.1625439
248S:S:F684 8.0925438
249S:S:I686 6.8154717
250S:S:F688 9.416538
251S:S:I692 9.955437
252S:S:I695 6.3675437
253S:S:Q735 6.652539
254S:S:W742 6.7775439
255S:S:F775 10.894534
256S:S:Y779 13.324539
257S:S:T780 9.695437
258S:S:L783 7.2075439
259S:S:F814 6.95509
260S:S:W818 8.87333639
261S:S:Y825 8.404539
262S:S:K831 8.18254459
263S:S:E837 8.9975439
264S:S:I841 4.066509
265S:S:L842 5.54754689
266S:S:K856 7.1854469
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:Y489 R:R:Y511 91.87495.96YesYes085
2R:R:L521 R:R:Y511 99.9777.03NoYes055
3R:R:I523 R:R:L521 1005.71NoNo065
4R:R:I523 R:R:Y203 99.99853.63NoYes865
5R:R:F204 R:R:Y203 50.011820.63YesYes875
6R:R:F204 R:R:W206 49.98798.02YesYes879
7R:R:V266 R:R:W206 50.1333.68YesYes879
8R:R:V209 R:R:V266 49.91766.41YesYes887
9R:R:I235 R:R:V209 49.19743.07NoYes078
10R:R:I235 R:R:N207 48.92462.83NoNo076
11R:R:W530 R:R:Y203 50.03595.79YesYes885
12R:R:W206 R:R:W530 50.01234.69YesYes898
13R:R:S540 R:R:W206 49.892111.12NoYes899
14R:R:S540 R:R:V209 49.85623.23NoYes898
15R:R:I187 R:R:P188 85.01723.39NoNo068
16R:R:I187 R:R:R185 84.95113.76NoYes069
17R:R:F183 R:R:R185 81.7976.41YesYes789
18R:R:F183 R:R:Q164 82.08319.37YesYes088
19R:R:L157 R:R:Q164 76.24213.99NoYes078
20R:R:I162 R:R:L157 76.20415.71NoNo067
21R:R:I162 R:R:N118 75.33957.08NoYes064
22R:R:N118 R:R:S137 74.84862.98YesNo044
23R:R:Q117 R:R:S137 74.55182.89NoNo064
24R:R:Q117 S:S:L125 74.32439.32NoNo2264
25S:S:D126 S:S:L125 76.99665.43YesNo2234
26R:R:D126 S:S:D126 76.58811.98NoYes033
27R:R:D126 R:R:L125 76.341717.64NoYes034
28R:R:L125 S:S:Q117 75.920810.65YesNo3946
29S:S:Q117 S:S:S137 75.9862.89NoNo064
30S:S:N118 S:S:S137 68.93382.98YesNo044
31S:S:I162 S:S:N118 68.2437.08NoYes064
32S:S:I162 S:S:L157 64.95215.71NoNo067
33S:S:L157 S:S:Q164 64.90783.99NoYes078
34S:S:F183 S:S:Q164 58.69599.37YesYes088
35S:S:F183 S:S:R185 57.14466.41YesYes589
36S:S:I187 S:S:R185 56.86673.76NoYes069
37S:S:I187 S:S:P188 56.76833.39NoNo068
38R:R:P188 R:R:Y489 82.97128.34NoYes088
39S:S:P188 S:S:Y489 50.18998.34NoYes088
40H:H:?5 H:H:?6 12.891633.21YesNo000
41H:H:?6 S:S:Y510 12.63945.24NoNo003
42S:S:F320 S:S:Y489 42.15825.16YesYes068
43S:S:F320 S:S:M197 35.13664.98YesYes067
44S:S:L294 S:S:M197 34.40318.48NoYes6077
45S:S:I200 S:S:L294 34.41385.71NoNo087
46S:S:I200 S:S:I201 34.35611.47NoNo086
47S:S:I201 S:S:I235 34.29841.47NoNo067
48S:S:I235 S:S:N207 33.94922.83NoYes076
49R:R:F320 R:R:Y489 11.25615.16YesYes068
50R:R:F320 R:R:Q193 16.14627.03YesYes069
51R:R:S296 R:R:Y218 15.21536.36NoNo087
52R:R:D216 R:R:Y218 14.74865.75NoNo067
53R:R:A214 R:R:D216 14.28174.63NoNo056
54R:R:A214 R:R:D275 14.04833.09NoNo055
55R:R:D238 R:R:F239 49.14145.97YesYes1186
56R:R:D238 R:R:W208 49.060922.33YesYes1189
57R:R:C561 R:R:W208 48.01693.92NoYes1199
58R:R:C561 R:R:N207 48.202311.02NoNo096
59R:R:C562 R:R:W208 92.82247.84YesYes1199
60R:R:F239 R:R:G210 50.41989.03YesNo068
61R:R:G210 R:R:V209 50.50943.68NoYes088
62R:R:C562 R:R:S543 92.65091.72YesNo098
63R:R:C546 R:R:S543 91.51971.72NoNo098
64R:R:C546 R:R:T550 91.13723.38NoYes5696
65R:R:E567 R:R:T550 90.76557.06NoYes046
66R:R:E567 R:R:H595 90.5773.69NoNo045
67R:R:H595 R:R:P569 89.91054.58NoNo055
68R:R:D570 R:R:P569 89.72151.61NoNo055
69R:R:D570 R:R:W590 89.532514.52NoNo056
70R:R:D758 R:R:W590 89.15457.82NoNo046
71R:R:D758 R:R:E759 88.96541.3NoNo044
72R:R:E759 R:R:I603 88.776421.86NoNo044
73R:R:F762 R:R:I603 82.52422.51NoNo074
74R:R:F605 R:R:F762 81.954622.51NoNo077
75R:R:F605 R:R:I763 80.434610.05NoNo077
76R:R:I763 R:R:P672 80.244513.55NoYes079
77R:R:P672 R:R:S750 78.91321.78YesNo096
78R:R:C677 R:R:S750 78.72291.72NoNo096
79R:R:C677 R:R:C765 78.53267.28NoNo099
80R:R:C765 R:R:R680 78.34232.79NoYes098
81R:R:E837 R:R:R680 77.19994.65YesYes098
82R:R:E837 R:R:V838 74.91275.7YesNo097
83R:R:L842 R:R:V838 74.72192.98NoNo097
84R:R:F662 R:R:L842 38.04649.74YesNo089
85R:R:F662 R:R:S845 36.11617.93YesNo088
86R:R:C661 R:R:S845 35.9233.44YesNo078
87R:R:L842 R:R:S665 36.48557.51NoNo098
88R:R:I841 R:R:S665 36.29249.29NoNo098
89R:R:C661 R:R:I841 35.90633.27YesNo079
90R:R:C661 R:R:S687 63.64675.16YesYes076
91R:R:L690 R:R:S687 14.09013YesYes076
92R:R:S687 R:R:Y779 32.05455.09YesYes069
93R:R:F775 R:R:Y779 10.18316.5YesYes449
94R:R:F814 R:R:S687 17.20085.28YesYes096
95R:R:F688 R:R:Y779 12.52415.47YesYes489
96R:R:I695 R:R:L783 11.73442.85NoYes079
97S:S:C561 S:S:N207 32.821912.6NoYes696
98S:S:C561 S:S:W208 32.69713.92NoYes699
99S:S:E558 S:S:W208 32.7918.72YesYes659
100S:S:E507 S:S:Y510 11.88214.49NoNo053
101S:S:E507 S:S:S490 11.37811.5NoNo058
102S:S:I492 S:S:S490 11.12563.1NoNo058
103S:S:E558 S:S:I555 32.68122.73YesNo055
104S:S:E564 S:S:I555 32.620612.3NoNo065
105S:S:E564 S:S:V566 32.49945.7NoNo064
106S:S:R551 S:S:V566 32.438710.46NoNo074
107S:S:C568 S:S:R551 16.08979.75NoNo1997
108S:S:C568 S:S:E572 16.02639.12NoYes1997
109S:S:C582 S:S:R551 16.28834.18YesNo1997
110S:S:C582 S:S:E572 16.026210.64YesYes1997
111S:S:E572 S:S:G549 31.26854.91YesNo1979
112S:S:A548 S:S:G549 31.15191.95NoNo049
113S:S:A548 S:S:D575 31.0221.54NoNo048
114S:S:D575 S:S:T596 30.89214.34NoNo085
115S:S:S597 S:S:T596 30.50211.6NoNo015
116S:S:S597 S:S:Y573 30.372117.8NoNo016
117S:S:N583 S:S:Y573 30.24219.3NoNo016
118S:S:C585 S:S:N583 29.98191.57YesNo091
119S:S:C585 S:S:F589 29.32862.79YesNo1395
120S:S:D588 S:S:F589 29.20092.39YesNo1365
121S:S:D588 S:S:E602 28.67487.8YesYes1363
122S:S:E602 S:S:I761 28.28388.2YesNo1337
123S:S:I603 S:S:I761 28.15822.94NoNo047
124S:S:F605 S:S:I603 27.76682.51YesNo074
125S:S:F605 S:S:K831 26.46089.93YesYes079
126S:S:E610 S:S:K831 25.93116.75YesYes4579
127S:S:E610 S:S:G613 25.54523.27YesNo078
128S:S:G613 S:S:L616 25.41435.13NoNo088
129S:S:I839 S:S:L616 25.28345.71NoNo078
130S:S:I839 S:S:L842 25.15252.85NoYes079
131S:S:F662 S:S:L842 24.757514.61YesYes6889
132S:S:F662 S:S:S845 17.8917.93YesNo088
133S:S:I841 S:S:S845 17.75913.1YesNo098
134S:S:I841 S:S:W818 16.30074.7YesYes099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7DTW
Class C
SubFamily Ion
Type Calcium Sensing
SubType CaS
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 4.5
Date 2021-03-10
D.O.I. 10.1038/s41422-021-00474-0
Net Summary
Imin 2.77
Number of Linked Nodes 1516
Number of Links 1822
Number of Hubs 266
Number of Links mediated by Hubs 943
Number of Communities 72
Number of Nodes involved in Communities 488
Number of Links involved in Communities 674
Path Summary
Number Of Nodes in MetaPath 135
Number Of Links MetaPath 134
Number of Shortest Paths 11101919
Length Of Smallest Path 3
Average Path Length 64.981
Length of Longest Path 130
Minimum Path Strength 1.07
Average Path Strength 7.33006
Maximum Path Strength 33.435
Minimum Path Correlation 0.7
Average Path Correlation 0.999656
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.75439
Average % Of Corr. Nodes 55.2512
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 37.9413
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • amino acid binding   • identical protein binding   • protein binding   • cation binding   • ion binding   • calcium ion binding   • metal ion binding   • small molecule binding   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • phosphoric ester hydrolase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • phospholipase C activity   • hydrolase activity   • phosphatidylinositol-4,5-bisphosphate phospholipase C activity   • catalytic activity   • phospholipase activity   • lipase activity   • transmembrane transporter binding   • cell adhesion molecule binding   • protein-containing complex binding   • integrin binding   • signaling receptor binding   • protein homodimerization activity   • protein dimerization activity   • kinase binding   • enzyme binding   • protein kinase binding   • biological regulation   • regulation of biological quality   • regulation of presynaptic membrane potential   • regulation of membrane potential   • regulation of calcium ion transport   • regulation of localization   • regulation of biological process   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • metal ion transport   • calcium ion transport   • localization
Gene OntologyBiological Process• biological regulation   • regulation of biological quality   • regulation of presynaptic membrane potential   • regulation of membrane potential   • regulation of calcium ion transport   • regulation of localization   • regulation of biological process   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • metal ion transport   • calcium ion transport   • localization   • monoatomic ion transport   • regulation of metal ion transport   • monoatomic cation transport   • developmental process   • multicellular organismal process   • epithelium development   • tube development   • branching morphogenesis of an epithelial tube   • morphogenesis of an epithelium   • tissue development   • tissue morphogenesis   • anatomical structure morphogenesis   • multicellular organism development   • tube morphogenesis   • morphogenesis of a branching structure   • anatomical structure development   • epithelial tube morphogenesis   • morphogenesis of a branching epithelium   • regulation of tube diameter   • system process   • regulation of tube size   • regulation of system process   • positive regulation of biological process   • positive regulation of vasoconstriction   • circulatory system process   • regulation of blood circulation   • vascular process in circulatory system   • regulation of vasoconstriction   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • blood vessel diameter maintenance   • vasoconstriction   • blood circulation   • regulation of anatomical structure size   • monoatomic ion transmembrane transport   • inorganic ion transmembrane transport   • inorganic anion transmembrane transport   • chloride transport   • transmembrane transport   • chloride transmembrane transport   • monoatomic anion transport   • monoatomic anion transmembrane transport   • cellular process   • inorganic anion transport   • regulation of biosynthetic process   • regulation of cellular process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • biosynthetic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • response to stimulus   • response to stress   • response to ischemia   • response to decreased oxygen levels   • cellular response to stimulus   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to chemical stimulus   • cellular response to stress   • response to hypoxia   • response to chemical   • response to oxygen levels   • response to abiotic stimulus   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • calcium ion homeostasis   • cellular homeostasis   • chemical homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis   • organic acid transport   • bile acid secretion   • organic anion transport   • monocarboxylic acid transport   • carboxylic acid transport   • secretion   • acid secretion   • response to peptide   • cellular response to peptide   • behavior   • chemosensory behavior   • signaling   • intracellular signal transduction   • cell communication   • JNK cascade   • intracellular signaling cassette   • MAPK cascade   • signal transduction   • cellular response to low-density lipoprotein particle stimulus   • response to endogenous stimulus   • response to lipoprotein particle   • response to nitrogen compound   • cellular response to lipoprotein particle stimulus   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • regulation of calcium ion import   • positive regulation of calcium ion transport   • positive regulation of calcium ion import   • positive regulation of transport   • positive regulation of monoatomic ion transport   • calcium ion import   • ossification   • connective tissue development   • adipose tissue development   • fat pad development   • animal organ development   • response to fibroblast growth factor   • response to growth factor   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • regulation of cell communication   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • response to oxygen-containing compound   • cellular response to glucose stimulus   • intracellular glucose homeostasis   • cellular response to oxygen-containing compound   • response to hexose   • cellular response to carbohydrate stimulus   • response to monosaccharide   • response to carbohydrate   • response to glucose   • glucose homeostasis   • carbohydrate homeostasis   • cellular response to hexose stimulus   • cellular response to monosaccharide stimulus   • response to nutrient levels   • response to lipid   • response to nutrient   • response to vitamin   • cellular response to vitamin D   • cellular response to nutrient levels   • response to vitamin D   • cellular response to vitamin   • cellular response to lipid   • cellular response to nutrient   • cell population proliferation   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • vasodilation   • positive chemotaxis   • chemotaxis   • positive regulation of locomotion   • regulation of response to external stimulus   • positive regulation of positive chemotaxis   • response to external stimulus   • regulation of chemotaxis   • positive regulation of chemotaxis   • regulation of positive chemotaxis   • positive regulation of response to external stimulus   • taxis   • regulation of locomotion   • locomotion   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • cellular response to endogenous stimulus   • response to hepatocyte growth factor   • cellular response to growth factor stimulus   • cellular response to hepatocyte growth factor stimulus   • protein localization   • establishment of protein localization   • nitrogen compound transport   • positive regulation of establishment of protein localization   • cellular macromolecule localization   • positive regulation of insulin secretion   • regulation of peptide hormone secretion   • regulation of hormone levels   • positive regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • protein secretion   • regulation of protein secretion   • regulation of secretion   • positive regulation of protein localization   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • positive regulation of secretion by cell   • hormone secretion   • protein localization to extracellular region   • positive regulation of protein transport   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • positive regulation of hormone secretion   • positive regulation of secretion   • amide transport   • signal release   • positive regulation of peptide secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • positive regulation of protein secretion   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • detection of stimulus   • response to metal ion   • detection of chemical stimulus   • detection of calcium ion   • response to calcium ion   • cell periphery   • presynapse   • cellular anatomical structure   • synapse   • cell junction   • membrane   • plasma membrane   • presynaptic membrane   • plasma membrane region   • synaptic membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • glutamatergic synapse
Gene OntologyCellular Component• cell periphery   • presynapse   • cellular anatomical structure   • synapse   • cell junction   • membrane   • plasma membrane   • presynaptic membrane   • plasma membrane region   • synaptic membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • glutamatergic synapse   • somatodendritic compartment   • cell body   • neuronal cell body   • apical part of cell   • apical plasma membrane   • cell surface   • axon   • neuron projection   • axon terminus   • plasma membrane bounded cell projection   • cell projection   • distal axon   • neuron projection terminus
SCOP2Domain Identifier• Type 1 solute binding protein-like   • TNF receptor-like
SCOP2Family Identifier• Type 1 solute binding protein-like   • TNF receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3 H:H:?4 H:H:?5 H:H:?6 H:H:?7 H:H:?8 H:H:?9 H:H:?10 H:H:?11 H:H:?12 H:H:?13 H:H:?14
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetyl-D-glucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP41180
Sequence
>7DTW_Chain_R
GPDQRAQKK GDIILGGLF PIHFGVAAK DQDLKSRPE SVECIRYNF 
RGFRWLQAM IFAIEEINS SPALLPNLT LGYRIFDTC NTVSKALEA 
TLSFVAQNK IDSLNLDEF CNCSEHIPS TIAVVGATG SGVSTAVAN 
LLGLFYIPQ VSYASSSRL LSNKNQFKS FLRTIPNDE HQATAMADI 
IEYFRWNWV GTIAADDDY GRPGIEKFR EEAEERDIC IDFSELISQ 
YSDEEEIQH VVEVIQNST AKVIVVFSS GPDLEPLIK EIVRRNITG 
KIWLASEAW ASSSLIAMP QYFHVVGGT IGFALKAGQ IPGFREFLK 
KVHPRKSVH NGFAKEFWE ETFNCHLQE FRPLCTGDE NISSVETPY 
IDYTHLRIS YNVYLAVYS IAHALQDIY TCLPGRGLF TNGSCADIK 
KVEAWQVLK HLRHLNFTN NMGEQVTFD ECGDLVGNY SIINWHLSP 
EDGSIVFKE VGYYNVYAK KGERLFINE EKILWSGFS REVPFSNCS 
RDCLAGTRK GIIEGEPTC CFECVECPD GEYSDETDA SACNKCPDD 
FWSNENHTS CIAKEIEFL SWTEPFGIA LTLFAVLGI FLTAFVLGV 
FIKFELSYL LLFSLLCCF SSSLFFIGE PQDWTCRLR QPAFGISFV 
LCISCILVK TNRQFLLVF LCTFMQIVI CVIWLYTAP PSSYRNQEL 
EDEIIFITC HEGSLMALG FLIGYTCLL AAICFFFAF KSRKLPENF 
NEAKFITFS MLIFFIVWI SFIPAYAST YGKFVSAVE VIAILAASF 
GLLACIFFN KIYI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtP41180
Sequence
>7DTW_Chain_S
GPDQRAQKK GDIILGGLF PIHFGVAAK DQDLKSRPE SVECIRYNF 
RGFRWLQAM IFAIEEINS SPALLPNLT LGYRIFDTC NTVSKALEA 
TLSFVAQNK IDSLNLDEF CNCSEHIPS TIAVVGATG SGVSTAVAN 
LLGLFYIPQ VSYASSSRL LSNKNQFKS FLRTIPNDE HQATAMADI 
IEYFRWNWV GTIAADDDY GRPGIEKFR EEAEERDIC IDFSELISQ 
YSDEEEIQH VVEVIQNST AKVIVVFSS GPDLEPLIK EIVRRNITG 
KIWLASEAW ASSSLIAMP QYFHVVGGT IGFALKAGQ IPGFREFLK 
KVHPRKSVH NGFAKEFWE ETFNCHLQE FRPLCTGDE NISSVETPY 
IDYTHLRIS YNVYLAVYS IAHALQDIY TCLPGRGLF TNGSCADIK 
KVEAWQVLK HLRHLNFTN NMGEQVTFD ECGDLVGNY SIINWHLSP 
EDGSIVFKE VGYYNVYAK KGERLFINE EKILWSGFS REVPFSNCS 
RDCLAGTRK GIIEGEPTC CFECVECPD GEYSDETDA SACNKCPDD 
FWSNENHTS CIAKEIEFL SWTEPFGIA LTLFAVLGI FLTAFVLGV 
FIKFELSYL LLFSLLCCF SSSLFFIGE PQDWTCRLR QPAFGISFV 
LCISCILVK TNRQFLLVF LCTFMQIVI CVIWLYTAP PSSYRNQEL 
EDEIIFITC HEGSLMALG FLIGYTCLL AAICFFFAF KSRKLPENF 
NEAKFITFS MLIFFIVWI SFIPAYAST YGKFVSAVE VIAILAASF 
GLLACIFFN KIYI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9C2FCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Tryptophan; '6218; PO4-2.82024-10-0210.1126/science.ado1868
9C1PCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan; '6218; PO4-2.82024-10-0210.1126/science.ado1868
9AXFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.52024-04-1710.1038/s41586-024-07331-1
9AXF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.52024-04-1710.1038/s41586-024-07331-1
9ASBCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.42024-04-1710.1038/s41586-024-07331-1
9ASB (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.42024-04-1710.1038/s41586-024-07331-1
9AVGCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs)/β1/γ23.62024-04-1710.1038/s41586-024-07331-1
9AVG (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-1710.1038/s41586-024-07331-1
9AYFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4Gi1/β1/γ23.62024-04-1710.1038/s41586-024-07331-1
9AYF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-1710.1038/s41586-024-07331-1
9AVLCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4Gi3/β2/γ23.82024-04-1710.1038/s41586-024-07331-1
9AVL (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.82024-04-1710.1038/s41586-024-07331-1
8SZFCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-2.82024-02-0710.1038/s41586-024-07055-2
8SZGCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCWchim(NtGi1-Gq)/β1/γ23.62024-02-0710.1038/s41586-024-07055-2
8SZG (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW3.62024-02-0710.1038/s41586-024-07055-2
8SZHCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCWGi1/β1/γ23.12024-02-0710.1038/s41586-024-07055-2
8SZH (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW3.12024-02-0710.1038/s41586-024-07055-2
8SZICIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCWGi3/β1/γ23.52024-02-0710.1038/s41586-024-07055-2
8SZI (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW3.52024-02-0710.1038/s41586-024-07055-2
8WPGCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca-2.72023-11-2210.1038/s41422-023-00892-2
8WPUCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Cachim(NtGi2L-Gs-CtGq)/β1/γ23.12023-11-2210.1038/s41422-023-00892-2
8WPU (No Gprot) CIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca3.12023-11-2210.1038/s41422-023-00892-2
7SINCIonCalcium SensingCaSHomo sapiens-NPS-2143-5.92022-01-1910.1073/pnas.2115849118
7SIMCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-2.72022-01-1910.1073/pnas.2115849118
7SILCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-2.72022-01-1910.1073/pnas.2115849118
7E6UCIonCalcium SensingCaSHomo sapiens---62021-09-2210.7554/eLife.68578
7E6TCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-32021-09-2210.7554/eLife.68578
7M3JCIonCalcium SensingCaSHomo sapiens-NPS-2143; PO4-4.12021-06-3010.1038/s41586-021-03691-0
7M3GCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4-2.52021-06-3010.1038/s41586-021-03691-0
7M3FCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4-2.82021-06-3010.1038/s41586-021-03691-0
7M3ECIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; NPS-2143-3.22021-06-3010.1038/s41586-021-03691-0
7DD7CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; Evocalcet-3.22021-06-1610.1126/sciadv.abg1483
7DD6CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan-3.22021-06-1610.1126/sciadv.abg1483
7DD5CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; NPS-2143-3.22021-06-1610.1126/sciadv.abg1483
7DTWCIonCalcium SensingCaSHomo sapiens---4.52021-03-1010.1038/s41422-021-00474-0
7DTVCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan-3.52021-03-1010.1038/s41422-021-00474-0
7DTUCIonCalcium SensingCaSHomo sapiens-Tryptophan-4.42021-03-1010.1038/s41422-021-00474-0
7DTTCIonCalcium SensingCaSHomo sapiensCaCa-3.82021-03-1010.1038/s41422-021-00474-0




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