Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:P22 3.2475415
2R:R:Q24 14.275415
3R:R:R25 5.925414
4R:R:G36 4.2275407
5R:R:I40 10.555415
6R:R:V44 4.89412
7R:R:P55 8.21254236
8R:R:Y63 11.012515
9R:R:N64 5.8325404
10R:R:F65 6.41667612
11R:R:R66 9.536515
12R:R:F68 11.065417
13R:R:W70 10.8275415
14R:R:Q72 4.885417
15R:R:E80 8.535498
16R:R:I81 5.655499
17R:R:N82 4.9025499
18R:R:L87 6.256596
19R:R:Y95 6.784448
20R:R:F98 3.21614
21R:R:K106 5.476514
22R:R:F114 4.7075405
23R:R:N118 6.85474
24R:R:K119 5.1625473
25R:R:L125 5.21333684
26R:R:D126 8.755483
27R:R:C129 4.335408
28R:R:I135 5.6875484
29R:R:F160 7.175477
30R:R:P163 4.194508
31R:R:Q164 4.536508
32R:R:Y167 6.1754458
33R:R:S169 5.355408
34R:R:R172 6.44134
35R:R:L174 5.814137
36R:R:F183 6.6165138
37R:R:R185 4.35754139
38R:R:Q193 8.09754389
39R:R:M197 6.064487
40R:R:Y203 10.74455
41R:R:W206 5.83571759
42R:R:W208 10.15867109
43R:R:V209 3.605458
44R:R:E229 5.285405
45R:R:D238 10.4945108
46R:R:F239 5.1256106
47R:R:Q245 9.8325404
48R:R:Q253 6.574243
49R:R:V256 6.69754245
50R:R:Q260 9.494245
51R:R:V266 4.895457
52R:R:F270 5.974387
53R:R:P274 4.61754463
54R:R:D275 2.864275
55R:R:L276 6.5525275
56R:R:E277 7.5445502
57R:R:E282 6.7525246
58R:R:R286 9.218336244
59R:R:S296 5.8725408
60R:R:W299 6.69254277
61R:R:Y310 10.0685503
62R:R:F320 4.992506
63R:R:F330 8.175418
64R:R:R331 10.485414
65R:R:F333 11.7725417
66R:R:F347 16.155415
67R:R:F351 10.206516
68R:R:W352 10.9985198
69R:R:E353 4.67254197
70R:R:C395 4.4054199
71R:R:G397 3.7254195
72R:R:E399 9.95754198
73R:R:T406 3.99514
74R:R:Y408 5.69714713
75R:R:Y411 11.464515
76R:R:L414 5.83416
77R:R:R415 6.6554515
78R:R:Y418 6.82667617
79R:R:Y421 10.81518
80R:R:Y425 9.125408
81R:R:I434 6.5154256
82R:R:Y435 6.604593
83R:R:F444 3.215253
84R:R:W458 10.45836254
85R:R:Q459 5.237147257
86R:R:L461 4.48507
87R:R:H463 5.2845255
88R:R:F469 8.845408
89R:R:N471 7.09516
90R:R:N472 8.62414
91R:R:M473 6.93514
92R:R:Q476 4.61754393
93R:R:D480 7.8154547
94R:R:N488 12.03754304
95R:R:Y489 5.8125408
96R:R:N493 8.105409
97R:R:W494 10.835177
98R:R:F505 7.94174
99R:R:Y511 6.948505
100R:R:V513 5.8354303
101R:R:Y514 8.5085304
102R:R:K517 4.74254471
103R:R:W530 10.3683658
104R:R:P538 5.69458
105R:R:N541 14.37455
106R:R:T550 5.03754566
107R:R:R551 4.95317
108R:R:E558 6.1954105
109R:R:C562 4.42254109
110R:R:E572 9.7925317
111R:R:C582 6.7954319
112R:R:C585 4.424329
113R:R:E602 8.04254573
114R:R:L606 11.7754209
115R:R:G623 1.985406
116R:R:L654 5.388336148
117R:R:L658 8.334148
118R:R:F662 7.218336338
119R:R:E671 3.6525404
120R:R:P672 10.2265209
121R:R:R678 6.11435
122R:R:Q681 6.17439
123R:R:F684 6.5375438
124R:R:F688 16.37438
125R:R:L690 6.754147
126R:R:I692 7.81667637
127R:R:L696 8.056538
128R:R:T732 7.4075407
129R:R:Q735 18.045439
130R:R:W742 12.176539
131R:R:N753 8.94207
132R:R:I763 8.374207
133R:R:F775 12.448534
134R:R:Y779 14.0533639
135R:R:L783 9.805439
136R:R:R795 7.041676289
137R:R:F814 9.01509
138R:R:W818 10.7375439
139R:R:F821 6.4375409
140R:R:Y825 12.44754409
141R:R:L842 7.76754339
142R:R:C851 4.444608
143R:R:F853 5.3845149
144S:S:P22 3.2475425
145S:S:Q24 14.275425
146S:S:R25 5.925424
147S:S:G36 4.2275407
148S:S:I40 10.555425
149S:S:V44 4.89422
150S:S:P55 8.544256
151S:S:Y63 11.012525
152S:S:N64 5.8325404
153S:S:F65 6.41667622
154S:S:R66 9.536525
155S:S:F68 11.065427
156S:S:W70 10.8275425
157S:S:Q72 4.885427
158S:S:E80 8.5354118
159S:S:I81 5.6554119
160S:S:N82 4.90254119
161S:S:L87 6.2565116
162S:S:Y95 6.784618
163S:S:F98 3.21624
164S:S:K106 5.476524
165S:S:F114 4.7075405
166S:S:N118 6.85474
167S:S:K119 4.81473
168S:S:L125 5.23684
169S:S:D126 8.755483
170S:S:C129 4.3025408
171S:S:I135 5.33484
172S:S:F160 7.5025477
173S:S:P163 4.194508
174S:S:Q164 4.536508
175S:S:Y167 6.1754628
176S:S:S169 5.355408
177S:S:R172 6.44154
178S:S:L174 5.814157
179S:S:F183 6.6165158
180S:S:R185 4.35754159
181S:S:Q193 8.09754419
182S:S:M197 6.064657
183S:S:Y203 10.74465
184S:S:W206 5.83571769
185S:S:W208 10.15867129
186S:S:V209 3.605468
187S:S:E229 5.285405
188S:S:D238 10.4945128
189S:S:F239 5.1256126
190S:S:Q245 9.8325404
191S:S:Q253 6.574263
192S:S:V256 6.69754265
193S:S:Q260 9.494265
194S:S:V266 4.895467
195S:S:F270 5.63754417
196S:S:P274 4.61754633
197S:S:D275 2.864295
198S:S:L276 6.5525295
199S:S:E277 7.5445672
200S:S:E282 6.7525266
201S:S:R286 9.218336264
202S:S:S296 5.54408
203S:S:W299 6.69254297
204S:S:Y310 10.0685673
205S:S:F320 4.992506
206S:S:F330 7.9075428
207S:S:R331 10.2175424
208S:S:F333 11.7725427
209S:S:F347 16.155425
210S:S:F351 10.206526
211S:S:W352 10.9985218
212S:S:E353 4.67254217
213S:S:C395 4.4054219
214S:S:G397 3.7254215
215S:S:E399 9.95754218
216S:S:T406 3.99524
217S:S:Y408 5.69714723
218S:S:Y411 11.464525
219S:S:L414 5.83426
220S:S:R415 6.6554685
221S:S:Y418 6.82667627
222S:S:Y421 10.81528
223S:S:Y425 9.125408
224S:S:I434 6.5154236
225S:S:Y435 6.6045113
226S:S:F444 3.215233
227S:S:W458 8.963336234
228S:S:Q459 5.237147237
229S:S:L461 4.48507
230S:S:H463 5.2845235
231S:S:F469 8.845408
232S:S:N471 7.09526
233S:S:N472 8.62424
234S:S:M473 6.93524
235S:S:Q476 4.61754423
236S:S:D480 7.8154707
237S:S:N488 12.03754344
238S:S:Y489 5.8125408
239S:S:N493 8.105409
240S:S:W494 10.835187
241S:S:F505 7.94184
242S:S:Y511 6.948505
243S:S:V513 5.8354343
244S:S:Y514 8.5085344
245S:S:K517 4.74254641
246S:S:W530 10.3683668
247S:S:P538 5.69468
248S:S:N541 14.37465
249S:S:T550 5.03754726
250S:S:R551 4.95357
251S:S:E558 6.1954125
252S:S:C562 4.42254129
253S:S:E572 9.7925357
254S:S:C582 6.7954359
255S:S:C585 4.424369
256S:S:E602 8.04254733
257S:S:L606 11.7754229
258S:S:G623 1.985406
259S:S:L654 5.388336168
260S:S:L658 8.334168
261S:S:F662 7.218336378
262S:S:E671 3.6525404
263S:S:P672 10.2265229
264S:S:R678 6.11445
265S:S:Q681 6.17449
266S:S:F684 6.5375448
267S:S:F688 16.37448
268S:S:L690 6.754167
269S:S:I692 7.81667647
270S:S:L696 8.056548
271S:S:T732 7.4075407
272S:S:Q735 18.045449
273S:S:W742 12.176549
274S:S:N753 8.94227
275S:S:I763 8.374227
276S:S:F775 12.448544
277S:S:Y779 14.0533649
278S:S:L783 9.805449
279S:S:R795 7.041676289
280S:S:F814 9.01509
281S:S:W818 10.7375449
282S:S:F821 6.4375409
283S:S:Y825 12.44754439
284S:S:L842 7.76754379
285S:S:C851 4.444768
286S:S:F853 5.3845169
287H:H:?1 22.94300
288H:H:?3 25.3775450
289H:H:?5 22.94340
290H:H:?7 25.3775460
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F114 R:R:F98 11.63754.29YesYes054
2R:R:I32 R:R:L93 41.83114.28NoNo069
3R:R:F114 R:R:V141 15.81043.93YesNo057
4R:R:Q164 R:R:V141 15.9752.87YesNo087
5R:R:L157 R:R:Q164 96.16453.99NoYes078
6R:R:I162 R:R:L157 96.21415.71NoNo067
7R:R:I162 R:R:N118 1007.08NoYes064
8R:R:N118 R:R:S137 42.33364.47YesNo044
9R:R:I139 R:R:S137 51.11033.1NoNo054
10R:R:I139 R:R:I32 42.18425.89NoNo056
11S:S:I162 S:S:P163 13.34443.39NoYes068
12S:S:I162 S:S:N118 99.4667.08NoYes064
13S:S:F160 S:S:N118 76.90568.46YesYes774
14R:R:L112 S:S:F160 76.93922.44NoYes757
15R:R:L112 S:S:K119 76.76024.23NoYes753
16R:R:K119 S:S:K119 76.92815.75YesYes733
17R:R:K119 S:S:L112 76.7555.64YesNo735
18R:R:F160 S:S:L112 76.93192.44YesNo775
19R:R:F160 R:R:N118 76.90298.46YesYes774
20S:S:I139 S:S:S137 50.99733.1NoNo054
21S:S:N118 S:S:S137 41.82664.47YesNo044
22S:S:Q117 S:S:S137 72.39922.89NoNo064
23R:R:L125 S:S:Q117 71.58889.32YesNo846
24R:R:D126 R:R:L125 48.89714.07YesYes834
25R:R:D126 R:R:N130 24.53464.04YesNo032
26R:R:N130 S:S:L125 24.7078.24NoYes024
27R:R:Q117 S:S:L125 72.93147.99NoYes864
28R:R:Q117 R:R:S137 73.03792.89NoNo064
29R:R:D126 S:S:D126 24.62111.98YesYes833
30S:S:D126 S:S:L125 48.89614.07YesYes834
31R:R:L125 S:S:N130 24.70828.24YesNo042
32S:S:D126 S:S:N130 24.53484.04YesNo032
33R:R:E80 R:R:I81 32.38694.1YesYes989
34R:R:F183 R:R:Q164 85.93599.37YesYes088
35R:R:I162 R:R:P163 13.68143.39NoYes068
36R:R:F183 R:R:R185 82.67456.41YesYes1389
37R:R:I187 R:R:R185 83.85283.76NoYes069
38R:R:I187 R:R:P188 83.76523.39NoNo068
39R:R:P188 R:R:Y489 75.68038.34NoYes088
40R:R:F320 R:R:Q193 31.13417.03YesYes069
41R:R:F320 R:R:Y489 71.43285.16YesYes068
42R:R:F270 R:R:Q193 15.37753.51YesYes3879
43R:R:E297 R:R:Q193 15.183214.02NoYes089
44R:R:F320 R:R:M197 69.1744.98YesYes067
45R:R:Y489 R:R:Y511 10.22875.96YesYes085
46R:R:L294 R:R:M197 67.95528.48NoYes4877
47R:R:I200 R:R:L294 68.62584.28NoNo087
48R:R:I523 R:R:Y203 14.76333.63NoYes065
49R:R:I523 R:R:L521 11.15035.71NoNo065
50R:R:L521 R:R:Y511 11.05157.03NoYes055
51R:R:D238 R:R:W208 81.590530.15YesYes1089
52R:R:D238 R:R:F239 81.53145.97YesYes1086
53R:R:F239 R:R:G210 81.99819.03YesNo068
54R:R:G210 R:R:V209 82.02991.84NoYes088
55R:R:I235 R:R:V209 68.54186.14NoYes078
56R:R:I201 R:R:I235 68.56531.47NoNo067
57R:R:I200 R:R:I201 68.59221.47NoNo086
58R:R:E558 R:R:W208 79.91516.54YesYes1059
59R:R:L276 R:R:W299 20.87526.83YesYes2757
60R:R:S296 R:R:W299 25.45944.94YesYes087
61R:R:I280 R:R:L276 17.8199.99NoYes055
62R:R:E277 R:R:P278 11.89261.57YesNo022
63R:R:I252 R:R:P278 11.10061.69NoNo042
64H:H:?1 H:H:?2 17.48233.04YesNo000
65H:H:?2 R:R:Y510 16.85945.23NoNo003
66R:R:E507 R:R:Y510 14.98914.49NoNo053
67R:R:E507 R:R:S490 13.744211.5NoNo058
68R:R:I492 R:R:S490 13.12083.1NoNo058
69R:R:V513 R:R:Y489 20.26443.79YesYes038
70R:R:V513 R:R:Y514 18.46418.83YesYes3034
71R:R:I327 R:R:L414 16.77164.28NoYes166
72R:R:I327 R:R:Y421 17.003620.55NoYes168
73R:R:Y418 R:R:Y421 11.26594.96YesYes178
74R:R:Y421 R:R:Y425 32.077113.9YesYes088
75R:R:C568 R:R:E572 40.538615.19NoYes3197
76R:R:C568 R:R:R551 40.6152.79NoYes3197
77R:R:R551 R:R:V566 81.407711.77YesNo074
78R:R:E564 R:R:V566 81.4225.7NoNo064
79R:R:E564 R:R:I555 81.43912.3NoNo065
80R:R:E558 R:R:I555 81.462.73YesNo055
81R:R:C582 R:R:E572 40.538613.67YesYes3197
82R:R:C582 R:R:R551 40.75692.79YesYes3197
83R:R:E572 R:R:H595 80.48832.46YesNo075
84R:R:H595 R:R:P569 80.270518.3NoNo055
85R:R:D570 R:R:P569 80.05341.61NoNo055
86R:R:D570 R:R:W590 79.836712.28NoNo056
87R:R:E602 R:R:I761 76.919813.66YesNo5737
88R:R:I603 R:R:I761 77.6962.94NoNo047
89R:R:E759 R:R:I603 78.76014.1NoNo044
90R:R:D758 R:R:E759 79.18833.9NoNo044
91R:R:D758 R:R:W590 79.403910.05NoNo046
92R:R:E604 R:R:K601 75.14661.35NoNo068
93R:R:E602 R:R:K601 75.35911.35YesNo038
94R:R:E604 R:R:L606 74.935213.25NoYes069
95R:R:L606 R:R:P672 71.931314.78YesYes2099
96R:R:G670 R:R:I669 70.53541.76NoNo078
97R:R:E671 R:R:G670 70.7321.64YesNo047
98R:R:E671 R:R:P672 71.71913.14YesYes049
99R:R:F853 R:R:L658 12.53923.65YesYes1498
100R:R:C661 R:R:L658 17.13224.76NoYes078
101R:R:C661 R:R:S687 20.0363.44NoNo076
102R:R:F814 R:R:S687 20.45032.64YesNo096
103R:R:F814 R:R:W818 27.463622.05YesYes099
104R:R:I841 R:R:W818 64.84383.52NoYes099
105R:R:E837 R:R:I841 65.17454.1NoNo099
106R:R:E837 R:R:R680 67.28245.82NoNo098
107R:R:R680 R:R:V838 67.06485.23NoNo5887
108R:R:I669 R:R:V838 68.37214.61NoNo087
109R:R:L776 R:R:W818 54.248212.53NoYes389
110R:R:F684 R:R:L776 55.48634.87YesNo388
111R:R:F684 R:R:F775 53.617115YesYes384
112R:R:F688 R:R:Y779 29.318710.32YesYes389
113R:R:F775 R:R:Y779 55.561924.76YesYes349
114R:R:F688 R:R:I692 28.864310.05YesYes387
115R:R:Q735 R:R:Y779 29.318728.18YesYes399
116R:R:I692 R:R:Q735 28.86432.74YesYes379
117R:R:I692 R:R:L696 55.90955.71YesYes378
118R:R:K698 R:R:L696 56.05224.23NoYes098
119R:R:F790 R:R:K698 55.791721.09NoNo079
120R:R:A791 R:R:R795 54.33712.77NoYes099
121R:R:A791 R:R:S794 54.35391.71NoNo099
122R:R:F790 R:R:S794 55.69231.32NoNo079
123R:R:F792 R:R:R795 55.02098.55NoYes2889
124R:R:F792 S:S:F792 55.52644.29NoNo2888
125S:S:I162 S:S:L157 95.73485.71NoNo067
126S:S:L157 S:S:Q164 95.68573.99NoYes078
127S:S:Q164 S:S:V141 15.93212.87YesNo087
128S:S:F114 S:S:V141 15.7683.93YesNo057
129S:S:F114 S:S:F98 11.60374.29YesYes054
130S:S:I139 S:S:I32 42.15155.89NoNo056
131S:S:I32 S:S:L93 41.79834.28NoNo069
132S:S:I81 S:S:L93 35.70895.71YesNo1199
133S:S:E80 S:S:I81 32.35574.1YesYes1189
134S:S:E80 S:S:Y425 32.537613.47YesYes088
135S:S:Y421 S:S:Y425 32.045213.9YesYes088
136S:S:I327 S:S:Y421 16.958820.55NoYes268
137S:S:I327 S:S:L414 16.72664.28NoYes266
138S:S:Y418 S:S:Y421 11.27374.96YesYes278
139S:S:F183 S:S:Q164 85.5029.37YesYes088
140S:S:F183 S:S:R185 82.25466.41YesYes1589
141S:S:I187 S:S:R185 83.4363.76NoYes069
142S:S:I187 S:S:P188 83.34953.39NoNo068
143S:S:P188 S:S:Y489 75.29788.34NoYes088
144S:S:F320 S:S:Y489 71.12165.16YesYes068
145S:S:F320 S:S:Q193 31.06957.03YesYes069
146S:S:F270 S:S:Q193 15.34573.51YesYes4179
147S:S:E297 S:S:Q193 15.151914.02NoYes089
148S:S:F320 S:S:M197 68.92894.98YesYes067
149S:S:Y489 S:S:Y511 10.19035.96YesYes085
150S:S:L294 S:S:M197 67.71718.48NoYes6577
151S:S:I200 S:S:L294 68.38834.28NoNo087
152S:S:L521 S:S:Y511 11.02087.03NoYes055
153S:S:I523 S:S:L521 11.125.71NoNo065
154S:S:I523 S:S:Y203 14.74063.63NoYes065
155S:S:I200 S:S:I201 68.35511.47NoNo086
156S:S:I201 S:S:I235 68.32871.47NoNo067
157S:S:I235 S:S:V209 68.30586.14NoYes078
158S:S:G210 S:S:V209 81.79431.84NoYes088
159S:S:F239 S:S:G210 81.76319.03YesNo068
160S:S:D238 S:S:F239 81.30045.97YesYes1286
161S:S:D238 S:S:W208 81.360530.15YesYes1289
162S:S:E558 S:S:W208 79.69316.54YesYes1259
163S:S:F270 S:S:S296 15.03435.28YesYes078
164S:S:E297 S:S:S296 14.98374.31NoYes088
165S:S:S296 S:S:W299 25.4044.94YesYes087
166S:S:L276 S:S:W299 20.82586.83YesYes2957
167S:S:I280 S:S:L276 17.77369.99NoYes055
168S:S:E277 S:S:P278 11.86231.57YesNo022
169S:S:I252 S:S:P278 11.07231.69NoNo042
170H:H:?5 H:H:?6 17.425533.04YesNo000
171H:H:?6 S:S:Y510 16.80495.23NoNo003
172S:S:E507 S:S:Y510 14.94064.49NoNo053
173S:S:E507 S:S:S490 13.699811.5NoNo058
174S:S:I492 S:S:S490 13.07843.1NoNo058
175S:S:V513 S:S:Y489 20.23213.79YesYes038
176S:S:V513 S:S:Y514 18.43178.83YesYes3434
177S:S:E558 S:S:I555 81.2392.73YesNo055
178S:S:E564 S:S:I555 81.218512.3NoNo065
179S:S:E564 S:S:V566 81.20215.7NoNo064
180S:S:R551 S:S:V566 81.188311.77YesNo074
181S:S:C568 S:S:R551 40.50632.79NoYes3597
182S:S:C568 S:S:E572 40.430415.19NoYes3597
183S:S:C582 S:S:R551 40.64772.79YesYes3597
184S:S:C582 S:S:E572 40.430413.67YesYes3597
185S:S:E572 S:S:H595 80.27492.46YesNo075
186S:S:H595 S:S:P569 80.058218.3NoNo055
187S:S:D570 S:S:P569 79.84211.61NoNo055
188S:S:D570 S:S:W590 79.626412.28NoNo056
189S:S:D758 S:S:W590 79.195610.05NoNo046
190S:S:D758 S:S:E759 78.9813.9NoNo044
191S:S:E759 S:S:I603 78.55484.1NoNo044
192S:S:I603 S:S:I761 77.49582.94NoNo047
193S:S:E602 S:S:I761 76.722513.66YesNo7337
194S:S:E602 S:S:K601 75.16991.35YesNo038
195S:S:E604 S:S:K601 74.95851.35NoNo068
196S:S:E604 S:S:L606 74.748113.25NoYes069
197S:S:L606 S:S:P672 71.755214.78YesYes2299
198S:S:E671 S:S:P672 71.54813.14YesYes049
199S:S:E671 S:S:G670 70.5661.64YesNo047
200S:S:G670 S:S:I669 70.37051.76NoNo078
201S:S:I669 S:S:V838 68.21834.61NoNo087
202S:S:R680 S:S:V838 66.9165.23NoNo7487
203S:S:E837 S:S:R680 67.13465.82NoNo098
204S:S:E837 S:S:I841 65.03674.1NoNo099
205S:S:I841 S:S:W818 64.70813.52NoYes099
206S:S:F814 S:S:W818 27.39822.05YesYes099
207S:S:F814 S:S:S687 20.40092.64YesNo096
208S:S:C661 S:S:S687 19.98763.44NoNo076
209S:S:C661 S:S:L658 17.09084.76NoYes078
210S:S:F853 S:S:L658 12.50893.65YesYes1698
211S:S:L776 S:S:W818 54.188212.53NoYes489
212S:S:F684 S:S:L776 55.42724.87YesNo488
213S:S:F684 S:S:F775 53.568215YesYes484
214S:S:F775 S:S:Y779 55.52524.76YesYes449
215S:S:F688 S:S:Y779 29.303810.32YesYes489
216S:S:F688 S:S:I692 28.852410.05YesYes487
217S:S:Q735 S:S:Y779 29.303828.18YesYes499
218S:S:I692 S:S:Q735 28.85242.74YesYes479
219S:S:I692 S:S:L696 55.90195.71YesYes478
220S:S:F792 S:S:R795 55.0358.55NoYes2889
221S:S:A791 S:S:R795 54.36082.77NoYes099
222S:S:A791 S:S:S794 54.37461.71NoNo099
223S:S:F790 S:S:S794 55.69731.32NoNo079
224S:S:F790 S:S:K698 55.794221.09NoNo079
225S:S:K698 S:S:L696 56.05074.23NoYes098
226R:R:F270 R:R:S296 15.06516.61YesYes078
227R:R:E297 R:R:S296 15.01454.31NoYes088
228R:R:E80 R:R:Y425 32.569213.47YesYes088
229R:R:I81 R:R:L93 35.73885.71YesNo999
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7DTW
Class C
SubFamily Ion
Type Calcium-sensing
SubType CaS
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 4.5
Date 2021-03-10
D.O.I. 10.1038/s41422-021-00474-0
Net Summary
Imin 2.61
Number of Linked Nodes 1512
Number of Links 1835
Number of Hubs 290
Number of Links mediated by Hubs 1041
Number of Communities 76
Number of Nodes involved in Communities 531
Number of Links involved in Communities 734
Path Summary
Number Of Nodes in MetaPath 230
Number Of Links MetaPath 229
Number of Shortest Paths 4832338
Length Of Smallest Path 3
Average Path Length 46.3993
Length of Longest Path 93
Minimum Path Strength 1.325
Average Path Strength 6.95957
Maximum Path Strength 33.3
Minimum Path Correlation 0.7
Average Path Correlation 0.998507
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.38983
Average % Of Corr. Nodes 57.1311
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.6729
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3 H:H:?4 H:H:?5 H:H:?6 H:H:?7 H:H:?8 H:H:?9 H:H:?10 H:H:?11 H:H:?12 H:H:?13 H:H:?14
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetyl-D-glucosamine
IdentifierN-[(2R,3R,4R,5S,6R)-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl]ethanamide
FormulaC8 H15 N O6
Molecular Weight221.208
SMILESCC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP41180
Sequence
>7DTW_Chain_R
GPDQRAQKK GDIILGGLF PIHFGVAAK DQDLKSRPE SVECIRYNF 
RGFRWLQAM IFAIEEINS SPALLPNLT LGYRIFDTC NTVSKALEA 
TLSFVAQNK IDSLNLDEF CNCSEHIPS TIAVVGATG SGVSTAVAN 
LLGLFYIPQ VSYASSSRL LSNKNQFKS FLRTIPNDE HQATAMADI 
IEYFRWNWV GTIAADDDY GRPGIEKFR EEAEERDIC IDFSELISQ 
YSDEEEIQH VVEVIQNST AKVIVVFSS GPDLEPLIK EIVRRNITG 
KIWLASEAW ASSSLIAMP QYFHVVGGT IGFALKAGQ IPGFREFLK 
KVHPRKSVH NGFAKEFWE ETFNCHLQE FRPLCTGDE NISSVETPY 
IDYTHLRIS YNVYLAVYS IAHALQDIY TCLPGRGLF TNGSCADIK 
KVEAWQVLK HLRHLNFTN NMGEQVTFD ECGDLVGNY SIINWHLSP 
EDGSIVFKE VGYYNVYAK KGERLFINE EKILWSGFS REVPFSNCS 
RDCLAGTRK GIIEGEPTC CFECVECPD GEYSDETDA SACNKCPDD 
FWSNENHTS CIAKEIEFL SWTEPFGIA LTLFAVLGI FLTAFVLGV 
FIKFELSYL LLFSLLCCF SSSLFFIGE PQDWTCRLR QPAFGISFV 
LCISCILVK TNRQFLLVF LCTFMQIVI CVIWLYTAP PSSYRNQEL 
EDEIIFITC HEGSLMALG FLIGYTCLL AAICFFFAF KSRKLPENF 
NEAKFITFS MLIFFIVWI SFIPAYAST YGKFVSAVE VIAILAASF 
GLLACIFFN KIYI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtP41180
Sequence
>7DTW_Chain_S
GPDQRAQKK GDIILGGLF PIHFGVAAK DQDLKSRPE SVECIRYNF 
RGFRWLQAM IFAIEEINS SPALLPNLT LGYRIFDTC NTVSKALEA 
TLSFVAQNK IDSLNLDEF CNCSEHIPS TIAVVGATG SGVSTAVAN 
LLGLFYIPQ VSYASSSRL LSNKNQFKS FLRTIPNDE HQATAMADI 
IEYFRWNWV GTIAADDDY GRPGIEKFR EEAEERDIC IDFSELISQ 
YSDEEEIQH VVEVIQNST AKVIVVFSS GPDLEPLIK EIVRRNITG 
KIWLASEAW ASSSLIAMP QYFHVVGGT IGFALKAGQ IPGFREFLK 
KVHPRKSVH NGFAKEFWE ETFNCHLQE FRPLCTGDE NISSVETPY 
IDYTHLRIS YNVYLAVYS IAHALQDIY TCLPGRGLF TNGSCADIK 
KVEAWQVLK HLRHLNFTN NMGEQVTFD ECGDLVGNY SIINWHLSP 
EDGSIVFKE VGYYNVYAK KGERLFINE EKILWSGFS REVPFSNCS 
RDCLAGTRK GIIEGEPTC CFECVECPD GEYSDETDA SACNKCPDD 
FWSNENHTS CIAKEIEFL SWTEPFGIA LTLFAVLGI FLTAFVLGV 
FIKFELSYL LLFSLLCCF SSSLFFIGE PQDWTCRLR QPAFGISFV 
LCISCILVK TNRQFLLVF LCTFMQIVI CVIWLYTAP PSSYRNQEL 
EDEIIFITC HEGSLMALG FLIGYTCLL AAICFFFAF KSRKLPENF 
NEAKFITFS MLIFFIVWI SFIPAYAST YGKFVSAVE VIAILAASF 
GLLACIFFN KIYI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7DD5CIonCalcium-sensingCaSGallus gallusCaCa; Ca; Tryptophan; NPS-2143-3.22021-06-1610.1126/sciadv.abg1483
7DD6CIonCalcium-sensingCaSGallus gallusCaCa; Ca; Tryptophan-3.22021-06-1610.1126/sciadv.abg1483
7DD7CIonCalcium-sensingCaSGallus gallusCaCa; Ca; Tryptophan; Evocalcet-3.22021-06-1610.1126/sciadv.abg1483
7DTTCIonCalcium-sensingCaSHomo sapiensCaCa-3.82021-03-1010.1038/s41422-021-00474-0
7DTUCIonCalcium-sensingCaSHomo sapiens-Tryptophan-4.42021-03-1010.1038/s41422-021-00474-0
7DTVCIonCalcium-sensingCaSHomo sapiensCaCa; Tryptophan-3.52021-03-1010.1038/s41422-021-00474-0
7DTWCIonCalcium-sensingCaSHomo sapiens---4.52021-03-1010.1038/s41422-021-00474-0
7E6TCIonCalcium-sensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-32021-09-2210.7554/eLife.68578
7E6UCIonCalcium-sensingCaSHomo sapiens---62021-09-2210.7554/eLife.68578
7M3ECIonCalcium-sensingCaSHomo sapiens-Ca; Ca; Tryptophan; NPS-2143; PO4-3.22021-06-3010.1038/s41586-021-03691-0
7M3FCIonCalcium-sensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4-2.82021-06-3010.1038/s41586-021-03691-0
7M3GCIonCalcium-sensingCaSHomo sapiens-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4-2.52021-06-3010.1038/s41586-021-03691-0
7M3JCIonCalcium-sensingCaSHomo sapiens-NPS-2143; PO4-4.12021-06-3010.1038/s41586-021-03691-0
7SILCIonCalcium-sensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-2.72022-01-1910.1073/pnas.2115849118
7SIMCIonCalcium-sensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-2.72022-01-1910.1073/pnas.2115849118
7SINCIonCalcium-sensingCaSHomo sapiens-NPS-2143-5.92022-01-1910.1073/pnas.2115849118
8SZFCIonCalcium-sensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-2.82024-02-0710.1038/s41586-024-07055-2
8SZGCIonCalcium-sensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCWchim(NtGi1-Gq)/&β;1/&γ;23.62024-02-0710.1038/s41586-024-07055-2
8SZHCIonCalcium-sensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCWGi1/&β;1/&γ;23.12024-02-0710.1038/s41586-024-07055-2
8SZICIonCalcium-sensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCWGi3/&β;1/&γ;23.52024-02-0710.1038/s41586-024-07055-2
8WPGCIonCalcium-sensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca-2.72023-11-2210.1038/s41422-023-00892-2
8WPUCIonCalcium-sensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Cachim(NtGi2L-Gs-CtGq)/&β;1/&γ;23.12023-11-2210.1038/s41422-023-00892-2
9AXFCIonCalcium-sensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/&β;1/&γ;23.52024-04-1710.1038/s41586-024-07331-1
9AYFCIonCalcium-sensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4Gi1/&β;1/&γ;23.62024-04-1710.1038/s41586-024-07331-1




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