psnGPCR

Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetyl-D-glucosamine
Identifier	N-[(2R,3R,4R,5S,6R)-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl]ethanamide
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES	CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0
Networks	170

This ligand is also present in the following 170 networks:

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

1F88

Sensory

Opsins

Rhodopsin

Bos taurus

11-cis-Retinal

2.8

2000-08-04

10.1126/science.289.5480.739

A 2D representation of the interactions of NAG in 1F88
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	7.31	2	Yes	No	7	6	1	1
R:R:T4	R:R:V20	12.69	2	No	Yes	6	6	1	2
H:H:?1	R:R:T4	5.26	2	Yes	No	0	6	0	1
R:R:G18	R:R:N15	5.09	2	No	Yes	3	7	1	1
R:R:N15	R:R:V20	8.87	2	Yes	Yes	7	6	1	2
H:H:?1	R:R:N15	24.5	2	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	0	1
H:H:?1	R:R:R21	14.09	2	Yes	No	0	4	0	1
H:H:?2	R:R:R21	14.09	2	No	No	0	4	1	1
H:H:?1	H:H:?2	35.24	2	Yes	No	0	0	0	1
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	17.04
Average Nodes In Shell	8.00
Average Hubs In Shell	3.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 1F88
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	7.31	2	Yes	No	7	6	2	2
H:H:?1	R:R:T4	5.26	2	Yes	No	0	6	1	2
R:R:G18	R:R:N15	5.09	2	No	Yes	3	7	2	2
H:H:?1	R:R:N15	24.5	2	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	1	2
H:H:?1	R:R:R21	14.09	2	Yes	No	0	4	1	1
H:H:?2	R:R:R21	14.09	2	No	No	0	4	0	1
H:H:?1	H:H:?2	35.24	2	Yes	No	0	0	1	0
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	24.66
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 1F88
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:M1	5.04	1	Yes	No	0	6	0	1
R:R:D282	R:R:N2	13.46	1	No	No	2	6	1	1
H:H:?3	R:R:N2	25.72	1	Yes	No	0	6	0	1
R:R:F283	R:R:S281	3.96	1	Yes	No	4	4	2	1
H:H:?3	R:R:D282	4.84	1	Yes	No	0	2	0	1
H:H:?3	H:H:?4	33.04	1	Yes	No	0	0	0	1
H:H:?3	R:R:S281	2.68	1	Yes	No	0	4	0	1
H:H:?4	R:R:S281	2.68	1	No	No	0	4	1	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.26
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 1F88
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:M1	5.04	1	Yes	No	0	6	1	2
R:R:D282	R:R:N2	13.46	1	No	No	2	6	2	2
H:H:?3	R:R:N2	25.72	1	Yes	No	0	6	1	2
R:R:F283	R:R:S281	3.96	1	Yes	No	4	4	2	1
H:H:?3	R:R:D282	4.84	1	Yes	No	0	2	1	2
H:H:?3	H:H:?4	33.04	1	Yes	No	0	0	1	0
H:H:?3	R:R:S281	2.68	1	Yes	No	0	4	1	1
H:H:?4	R:R:S281	2.68	1	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	17.86
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

1GZM

Sensory

Opsins

Rhodopsin

Bos taurus

11-cis-Retinal

2.65

2003-11-20

10.1016/j.jmb.2004.08.090

A 2D representation of the interactions of NAG in 1GZM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	5.85	2	Yes	No	7	6	1	2
R:R:T4	R:R:V20	12.69	2	No	Yes	6	6	2	2
R:R:G18	R:R:N15	5.09	2	No	Yes	3	7	1	1
R:R:N15	R:R:V20	10.35	2	Yes	Yes	7	6	1	2
H:H:?1	R:R:N15	22.05	2	No	Yes	0	7	0	1
H:H:?1	R:R:G18	7.63	2	No	No	0	3	0	1
H:H:?2	R:R:R21	5.42	0	No	No	0	4	1	2
H:H:?1	H:H:?2	28.63	2	No	No	0	0	0	1
H:H:?2	H:H:?3	32.02	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	19.44
Average Nodes In Shell	8.00
Average Hubs In Shell	2.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 1GZM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:G18	R:R:N15	5.09	2	No	Yes	3	7	2	2
H:H:?1	R:R:N15	22.05	2	No	Yes	0	7	1	2
H:H:?1	R:R:G18	7.63	2	No	No	0	3	1	2
R:R:E25	R:R:R21	8.14	0	No	No	7	4	2	1
H:H:?2	R:R:R21	5.42	0	No	No	0	4	0	1
H:H:?1	H:H:?2	28.63	2	No	No	0	0	1	0
H:H:?2	H:H:?3	32.02	0	No	No	0	0	0	1
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	22.02
Average Nodes In Shell	8.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	2.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 1GZM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	16.16	4	No	No	2	6	1	1
H:H:?4	R:R:N2	29.4	4	No	No	0	6	0	1
H:H:?4	R:R:D282	9.68	4	No	No	0	2	0	1
H:H:?4	H:H:?5	38.55	4	No	No	0	0	0	1
H:H:?5	H:H:?6	28.17	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	25.88
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 1GZM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	16.16	4	No	No	2	6	2	2
H:H:?4	R:R:N2	29.4	4	No	No	0	6	1	2
H:H:?4	R:R:D282	9.68	4	No	No	0	2	1	2
H:H:?4	H:H:?5	38.55	4	No	No	0	0	1	0
H:H:?5	H:H:?6	28.17	0	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	33.36
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

1HZX

Sensory

Opsins

Rhodopsin

Bos taurus

11-cis-Retinal

2.8

2001-07-04

10.1021/bi0155091

A 2D representation of the interactions of NAG in 1HZX
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:T4	R:R:V20	9.52	1	No	Yes	6	6	1	1
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	0	1
R:R:V11	R:R:V20	4.81	1	No	Yes	8	6	2	1
R:R:V11	R:R:Y30	3.79	1	No	Yes	8	4	2	2
R:R:F13	R:R:V20	5.24	1	No	Yes	4	6	2	1
R:R:F13	R:R:Y30	8.25	1	No	Yes	4	4	2	2
R:R:G18	R:R:N15	5.09	1	No	No	3	7	1	1
R:R:N15	R:R:V20	11.82	1	No	Yes	7	6	1	1
H:H:?1	R:R:N15	28.17	1	Yes	No	0	7	0	1
H:H:?1	R:R:G18	7.63	1	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	10.09	1	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	6.64	1	Yes	Yes	0	6	0	1
H:H:?1	H:H:?2	36.34	1	Yes	No	0	0	0	1
H:H:?2	H:H:?3	36.82	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	16.81
Average Nodes In Shell	10.00
Average Hubs In Shell	3.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 1HZX
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:T4	R:R:V20	9.52	1	No	Yes	6	6	2	2
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	1	2
R:R:G18	R:R:N15	5.09	1	No	No	3	7	2	2
R:R:N15	R:R:V20	11.82	1	No	Yes	7	6	2	2
H:H:?1	R:R:N15	28.17	1	Yes	No	0	7	1	2
H:H:?1	R:R:G18	7.63	1	Yes	No	0	3	1	2
H:H:?1	R:R:V20	6.64	1	Yes	Yes	0	6	1	2
H:H:?1	H:H:?2	36.34	1	Yes	No	0	0	1	0
H:H:?2	H:H:?3	36.82	0	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	36.58
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 1HZX
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	10.77	4	No	No	2	6	1	1
H:H:?4	R:R:N2	28.17	4	Yes	No	0	6	0	1
H:H:?4	R:R:G280	4.58	4	Yes	No	0	1	0	1
R:R:F283	R:R:S281	3.96	1	Yes	No	4	4	2	1
H:H:?4	R:R:S281	5.36	4	Yes	No	0	4	0	1
H:H:?4	R:R:D282	4.84	4	Yes	No	0	2	0	1
H:H:?4	H:H:?5	42.95	4	Yes	No	0	0	0	1
H:H:?4	R:R:M1	2.52	4	Yes	No	0	6	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.74
Average Nodes In Shell	8.00
Average Hubs In Shell	2.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 1HZX
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	10.77	4	No	No	2	6	2	2
H:H:?4	R:R:N2	28.17	4	Yes	No	0	6	1	2
H:H:?4	R:R:G280	4.58	4	Yes	No	0	1	1	2
H:H:?4	R:R:S281	5.36	4	Yes	No	0	4	1	2
H:H:?4	R:R:D282	4.84	4	Yes	No	0	2	1	2
H:H:?4	H:H:?5	42.95	4	Yes	No	0	0	1	0
H:H:?4	R:R:M1	2.52	4	Yes	No	0	6	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	42.95
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

1L9H

Sensory

Opsins

Rhodopsin

Bos taurus

11-cis-Retinal

2.6

2002-05-15

10.1073/pnas.082666399

A 2D representation of the interactions of NAG in 1L9H
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:T4	R:R:V20	9.52	0	No	Yes	6	6	1	2
H:H:?1	R:R:T4	6.57	1	Yes	No	0	6	0	1
R:R:G18	R:R:N15	5.09	1	No	No	3	7	1	1
R:R:N15	R:R:V20	8.87	1	No	Yes	7	6	1	2
H:H:?1	R:R:N15	23.27	1	Yes	No	0	7	0	1
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	0	1
H:H:?1	H:H:?2	42.95	1	Yes	No	0	0	0	1
H:H:?2	H:H:?3	46.97	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	19.72
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 1L9H
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:T4	6.57	1	Yes	No	0	6	1	2
R:R:G18	R:R:N15	5.09	1	No	No	3	7	2	2
H:H:?1	R:R:N15	23.27	1	Yes	No	0	7	1	2
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	1	2
H:H:?1	H:H:?2	42.95	1	Yes	No	0	0	1	0
H:H:?2	H:H:?3	46.97	0	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	44.96
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 1L9H
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	12.12	4	No	No	2	6	1	1
H:H:?4	R:R:N2	24.5	4	Yes	No	0	6	0	1
H:H:?4	R:R:D282	6.05	4	Yes	No	0	2	0	1
H:H:?4	H:H:?5	50.66	4	Yes	No	0	0	0	1
H:H:?4	R:R:G280	3.05	4	Yes	No	0	1	0	1
H:H:?4	R:R:M1	2.52	4	Yes	No	0	6	0	1
R:R:G280	R:R:Y10	1.45	0	No	No	1	7	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	17.36
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 1L9H
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	12.12	4	No	No	2	6	2	2
H:H:?4	R:R:N2	24.5	4	Yes	No	0	6	1	2
H:H:?4	R:R:D282	6.05	4	Yes	No	0	2	1	2
H:H:?4	H:H:?5	50.66	4	Yes	No	0	0	1	0
H:H:?4	R:R:G280	3.05	4	Yes	No	0	1	1	2
H:H:?4	R:R:M1	2.52	4	Yes	No	0	6	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	50.66
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

1U19

Sensory

Opsins

Rhodopsin

Bos taurus

11-cis-Retinal

2.2

2004-10-12

10.1016/j.jmb.2004.07.044

A 2D representation of the interactions of NAG in 1U19
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	4.39	2	Yes	No	7	6	1	1
R:R:T4	R:R:V20	12.69	2	No	Yes	6	6	1	1
H:H:?1	R:R:T4	5.26	2	Yes	No	0	6	0	1
R:R:V11	R:R:V20	4.81	0	No	Yes	8	6	2	1
R:R:F13	R:R:V20	5.24	2	Yes	Yes	4	6	2	1
R:R:F13	R:R:Y30	8.25	2	Yes	Yes	4	4	2	2
R:R:G18	R:R:N15	6.79	2	No	Yes	3	7	1	1
R:R:N15	R:R:V20	10.35	2	Yes	Yes	7	6	1	1
H:H:?1	R:R:N15	24.5	2	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	11.36	2	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	3.99	2	Yes	Yes	0	6	0	1
H:H:?1	H:H:?2	41.85	2	Yes	No	0	0	0	1
H:H:?2	H:H:?3	31.74	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	16.34
Average Nodes In Shell	10.00
Average Hubs In Shell	5.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	13.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 1U19
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	4.39	2	Yes	No	7	6	2	2
R:R:T4	R:R:V20	12.69	2	No	Yes	6	6	2	2
H:H:?1	R:R:T4	5.26	2	Yes	No	0	6	1	2
R:R:G18	R:R:N15	6.79	2	No	Yes	3	7	2	2
R:R:N15	R:R:V20	10.35	2	Yes	Yes	7	6	2	2
H:H:?1	R:R:N15	24.5	2	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	1	2
H:H:?1	R:R:V20	3.99	2	Yes	Yes	0	6	1	2
H:H:?1	H:H:?2	41.85	2	Yes	No	0	0	1	0
H:H:?2	H:H:?3	31.74	0	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	36.80
Average Nodes In Shell	7.00
Average Hubs In Shell	3.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 1U19
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	13.46	8	No	No	2	6	1	1
H:H:?4	R:R:N2	26.95	8	Yes	No	0	6	0	1
H:H:?4	R:R:D282	6.05	8	Yes	No	0	2	0	1
H:H:?4	H:H:?5	39.65	8	Yes	No	0	0	0	1
R:R:H278	R:R:S281	2.79	0	No	No	3	4	2	1
H:H:?4	R:R:S281	2.68	8	Yes	No	0	4	0	1
H:H:?4	R:R:M1	2.52	8	Yes	No	0	6	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.57
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 1U19
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	13.46	8	No	No	2	6	2	2
H:H:?4	R:R:N2	26.95	8	Yes	No	0	6	1	2
H:H:?4	R:R:D282	6.05	8	Yes	No	0	2	1	2
H:H:?4	H:H:?5	39.65	8	Yes	No	0	0	1	0
H:H:?4	R:R:S281	2.68	8	Yes	No	0	4	1	2
H:H:?4	R:R:M1	2.52	8	Yes	No	0	6	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	39.65
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

2G87

Sensory

Opsins

Rhodopsin

Bos taurus

All-trans-retinal

2.6

2006-09-02

10.1002/anie.200600595

A 2D representation of the interactions of NAG in 2G87
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	5.85	1	Yes	No	7	6	1	1
R:R:T4	R:R:V20	12.69	1	No	Yes	6	6	1	1
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	0	1
R:R:V11	R:R:V20	4.81	1	Yes	Yes	8	6	2	1
R:R:V11	R:R:Y30	3.79	1	Yes	Yes	8	4	2	2
R:R:F13	R:R:V20	5.24	1	No	Yes	4	6	2	1
R:R:F13	R:R:Y30	8.25	1	No	Yes	4	4	2	2
R:R:G18	R:R:N15	5.09	1	No	Yes	3	7	1	1
R:R:N15	R:R:V20	10.35	1	Yes	Yes	7	6	1	1
H:H:?1	R:R:N15	24.5	1	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	4.58	1	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	11.36	1	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	5.32	1	Yes	Yes	0	6	0	1
H:H:?1	H:H:?2	40.75	1	Yes	No	0	0	0	1
H:H:?2	H:H:?3	31.74	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	16.08
Average Nodes In Shell	10.00
Average Hubs In Shell	5.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	14.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 2G87
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	5.85	1	Yes	No	7	6	2	2
R:R:T4	R:R:V20	12.69	1	No	Yes	6	6	2	2
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	1	2
R:R:G18	R:R:N15	5.09	1	No	Yes	3	7	2	2
R:R:N15	R:R:V20	10.35	1	Yes	Yes	7	6	2	2
H:H:?1	R:R:N15	24.5	1	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	4.58	1	Yes	No	0	3	1	2
H:H:?1	R:R:V20	5.32	1	Yes	Yes	0	6	1	2
H:H:?1	H:H:?2	40.75	1	Yes	No	0	0	1	0
H:H:?2	H:H:?3	31.74	0	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	36.24
Average Nodes In Shell	7.00
Average Hubs In Shell	3.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 2G87
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	13.46	9	No	No	2	6	1	1
H:H:?4	R:R:N2	25.72	9	Yes	No	0	6	0	1
H:H:?4	R:R:D282	6.05	9	Yes	No	0	2	0	1
H:H:?4	H:H:?5	41.85	9	Yes	No	0	0	0	1
R:R:H278	R:R:S281	2.79	0	No	No	3	4	2	1
H:H:?4	R:R:S281	2.68	9	Yes	No	0	4	0	1
H:H:?4	R:R:M1	2.52	9	Yes	No	0	6	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.76
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 2G87
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	13.46	9	No	No	2	6	2	2
H:H:?4	R:R:N2	25.72	9	Yes	No	0	6	1	2
H:H:?4	R:R:D282	6.05	9	Yes	No	0	2	1	2
H:H:?4	H:H:?5	41.85	9	Yes	No	0	0	1	0
H:H:?4	R:R:S281	2.68	9	Yes	No	0	4	1	2
H:H:?4	R:R:M1	2.52	9	Yes	No	0	6	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	41.85
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

2HPY

Sensory

Opsins

Rhodopsin

Bos taurus

All-trans-retinal

2.8

2006-08-22

10.1073/pnas.0601765103

A 2D representation of the interactions of NAG in 2HPY
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	7.31	2	Yes	No	7	6	1	2
R:R:T4	R:R:V20	12.69	2	No	Yes	6	6	2	1
R:R:V11	R:R:V20	4.81	0	No	Yes	8	6	2	1
R:R:F13	R:R:V20	5.24	2	No	Yes	4	6	2	1
R:R:F13	R:R:Y30	7.22	2	No	Yes	4	4	2	2
R:R:G18	R:R:N15	5.09	2	No	Yes	3	7	1	1
R:R:N15	R:R:V20	10.35	2	Yes	Yes	7	6	1	1
H:H:?6	R:R:N15	29.4	2	Yes	Yes	0	7	0	1
H:H:?6	R:R:G18	7.63	2	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	10.09	2	Yes	Yes	6	4	1	2
H:H:?6	R:R:V20	7.97	2	Yes	Yes	0	6	0	1
H:H:?6	H:H:?7	42.95	2	Yes	No	0	0	0	1
H:H:?7	H:H:?8	26.89	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	21.99
Average Nodes In Shell	10.00
Average Hubs In Shell	4.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 2HPY
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:G18	R:R:N15	5.09	2	No	Yes	3	7	2	2
R:R:N15	R:R:V20	10.35	2	Yes	Yes	7	6	2	2
H:H:?6	R:R:N15	29.4	2	Yes	Yes	0	7	1	2
H:H:?6	R:R:G18	7.63	2	Yes	No	0	3	1	2
H:H:?6	R:R:V20	7.97	2	Yes	Yes	0	6	1	2
H:H:?6	H:H:?7	42.95	2	Yes	No	0	0	1	0
H:H:?7	H:H:?8	26.89	0	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	34.92
Average Nodes In Shell	6.00
Average Hubs In Shell	3.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 2HPY
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	6.73	10	No	No	2	6	1	1
H:H:?9	R:R:N2	30.62	10	Yes	No	0	6	0	1
R:R:S281	R:R:Y274	5.09	0	No	No	4	4	1	2
H:H:?9	R:R:D282	6.05	10	Yes	No	0	2	0	1
H:H:?10	H:H:?9	36.34	0	No	Yes	0	0	1	0
H:H:?9	R:R:S281	2.68	10	Yes	No	0	4	0	1
H:H:?9	R:R:M1	2.52	10	Yes	No	0	6	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.64
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 2HPY
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	6.73	10	No	No	2	6	2	2
H:H:?9	R:R:N2	30.62	10	Yes	No	0	6	1	2
H:H:?9	R:R:D282	6.05	10	Yes	No	0	2	1	2
H:H:?10	H:H:?9	36.34	0	No	Yes	0	0	0	1
H:H:?9	R:R:S281	2.68	10	Yes	No	0	4	1	2
H:H:?9	R:R:M1	2.52	10	Yes	No	0	6	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	36.34
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

2I35

Sensory

Opsins

Rhodopsin

Bos taurus

11-cis-Retinal

3.8

2006-10-17

10.1073/pnas.0608022103

A 2D representation of the interactions of NAG in 2I35
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	5.85	2	Yes	Yes	7	6	1	1
R:R:T4	R:R:V20	7.93	2	Yes	Yes	6	6	1	2
H:H:?1	R:R:T4	3.94	2	Yes	Yes	0	6	0	1
R:R:G18	R:R:N15	5.09	2	No	Yes	3	7	1	1
R:R:N15	R:R:V20	11.82	2	Yes	Yes	7	6	1	2
H:H:?1	R:R:N15	24.5	2	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	7.63	2	Yes	No	0	3	0	1
R:R:A26	R:R:R21	4.15	0	No	No	2	4	2	1
H:H:?1	R:R:R21	5.42	2	Yes	No	0	4	0	1
H:H:?1	H:H:?2	33.04	2	Yes	No	0	0	0	1
H:H:?2	H:H:?3	30.74	0	No	No	0	0	1	2
R:R:G3	R:R:T4	1.82	0	No	Yes	6	6	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	14.91
Average Nodes In Shell	10.00
Average Hubs In Shell	4.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 2I35
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	5.85	2	Yes	Yes	7	6	2	2
H:H:?1	R:R:T4	3.94	2	Yes	Yes	0	6	1	2
R:R:G18	R:R:N15	5.09	2	No	Yes	3	7	2	2
H:H:?1	R:R:N15	24.5	2	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	7.63	2	Yes	No	0	3	1	2
H:H:?1	R:R:R21	5.42	2	Yes	No	0	4	1	2
H:H:?1	H:H:?2	33.04	2	Yes	No	0	0	1	0
H:H:?2	H:H:?3	30.74	0	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	31.89
Average Nodes In Shell	7.00
Average Hubs In Shell	3.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 2I35
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	8.08	6	No	No	2	6	1	1
H:H:?4	R:R:N2	25.72	6	No	No	0	6	0	1
H:H:?4	R:R:D282	13.32	6	No	No	0	2	0	1
H:H:?4	H:H:?5	37.44	6	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	25.49
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 2I35
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	8.08	6	No	No	2	6	2	2
H:H:?4	R:R:N2	25.72	6	No	No	0	6	1	2
H:H:?4	R:R:D282	13.32	6	No	No	0	2	1	2
H:H:?4	H:H:?5	37.44	6	No	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	37.44
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

2I36

Sensory

Opsins

Rhodopsin

Bos taurus

4.1

2006-10-17

10.1073/pnas.0608022103

A 2D representation of the interactions of NAG in 2I36
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:G6	R:R:P7	4.06	2	No	No	6	6	2	2
R:R:F9	R:R:G6	9.03	2	Yes	No	7	6	1	2
R:R:F9	R:R:P7	7.22	2	Yes	No	7	6	1	2
R:R:F9	R:R:S22	6.61	2	Yes	Yes	7	5	1	2
R:R:F9	R:R:P23	7.22	2	Yes	Yes	7	5	1	2
R:R:F24	R:R:F9	5.36	2	Yes	Yes	5	7	2	1
H:H:?1	R:R:F9	3.26	2	Yes	Yes	0	7	0	1
R:R:G18	R:R:N15	3.39	2	No	No	3	7	1	1
R:R:N15	R:R:V20	5.91	2	No	Yes	7	6	1	2
H:H:?1	R:R:N15	28.17	2	Yes	No	0	7	0	1
H:H:?1	R:R:G18	3.05	2	Yes	No	0	3	0	1
R:R:P23	R:R:S22	5.34	2	Yes	Yes	5	5	2	2
R:R:F24	R:R:S22	5.28	2	Yes	Yes	5	5	2	2
R:R:F24	R:R:P23	8.67	2	Yes	Yes	5	5	2	2
H:H:?1	H:H:?2	36.34	2	Yes	No	0	0	0	1
H:H:?2	H:H:?3	33.01	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	17.70
Average Nodes In Shell	12.00
Average Hubs In Shell	6.00
Average Links In Shell	16.00
Average Links Mediated by Hubs In Shell	13.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 2I36
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:F9	3.26	2	Yes	Yes	0	7	1	2
R:R:G18	R:R:N15	3.39	2	No	No	3	7	2	2
H:H:?1	R:R:N15	28.17	2	Yes	No	0	7	1	2
H:H:?1	R:R:G18	3.05	2	Yes	No	0	3	1	2
H:H:?1	H:H:?2	36.34	2	Yes	No	0	0	1	0
H:H:?2	H:H:?3	33.01	0	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	34.67
Average Nodes In Shell	6.00
Average Hubs In Shell	2.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 2I36
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	10.77	6	No	No	2	6	1	1
H:H:?4	R:R:N2	30.62	6	Yes	No	0	6	0	1
H:H:?4	R:R:D282	7.26	6	Yes	No	0	2	0	1
H:H:?4	H:H:?5	35.24	6	Yes	No	0	0	0	1
H:H:?4	R:R:G280	1.53	6	Yes	No	0	1	0	1
R:R:G280	R:R:Y10	1.45	0	No	No	1	7	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.66
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 2I36
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	10.77	6	No	No	2	6	2	2
H:H:?4	R:R:N2	30.62	6	Yes	No	0	6	1	2
H:H:?4	R:R:D282	7.26	6	Yes	No	0	2	1	2
H:H:?4	H:H:?5	35.24	6	Yes	No	0	0	1	0
H:H:?4	R:R:G280	1.53	6	Yes	No	0	1	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	35.24
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

2I37

Sensory

Opsins

Rhodopsin

Bos taurus

4.15

2006-10-17

10.1073/pnas.0608022103

A 2D representation of the interactions of NAG in 2I37
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	2.92	2	Yes	No	7	6	1	2
R:R:T4	R:R:V20	9.52	2	No	No	6	6	2	2
R:R:G18	R:R:N15	3.39	2	No	Yes	3	7	1	1
R:R:N15	R:R:V20	8.87	2	Yes	No	7	6	1	2
H:H:?1	R:R:N15	29.4	2	No	Yes	0	7	0	1
H:H:?1	R:R:G18	3.05	2	No	No	0	3	0	1
H:H:?1	H:H:?2	34.14	2	No	No	0	0	0	1
H:H:?2	H:H:?3	30.47	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	22.20
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 2I37
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:G18	R:R:N15	3.39	2	No	Yes	3	7	2	2
H:H:?1	R:R:N15	29.4	2	No	Yes	0	7	1	2
H:H:?1	R:R:G18	3.05	2	No	No	0	3	1	2
H:H:?1	H:H:?2	34.14	2	No	No	0	0	1	0
H:H:?2	H:H:?3	30.47	0	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	32.30
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	2.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 2I37
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	13.46	4	No	No	2	6	1	1
H:H:?4	R:R:N2	30.62	4	Yes	No	0	6	0	1
H:H:?5	R:R:H278	3.44	4	No	No	0	3	1	2
H:H:?4	R:R:S281	4.02	4	Yes	No	0	4	0	1
H:H:?5	R:R:S281	4.02	4	No	No	0	4	1	1
H:H:?4	R:R:D282	4.84	4	Yes	No	0	2	0	1
H:H:?4	H:H:?5	30.84	4	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	17.58
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 2I37
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	13.46	4	No	No	2	6	2	2
H:H:?4	R:R:N2	30.62	4	Yes	No	0	6	1	2
R:R:H278	R:R:Y274	25.04	0	No	No	3	4	1	2
R:R:H278	R:R:T277	5.48	0	No	No	3	5	1	2
H:H:?5	R:R:H278	3.44	4	No	No	0	3	0	1
H:H:?4	R:R:S281	4.02	4	Yes	No	0	4	1	1
H:H:?5	R:R:S281	4.02	4	No	No	0	4	0	1
H:H:?4	R:R:D282	4.84	4	Yes	No	0	2	1	2
H:H:?4	H:H:?5	30.84	4	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	12.77
Average Nodes In Shell	8.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

2J4Y

Sensory

Opsins

Rhodopsin

Bos taurus

11-cis-Retinal

3.4

2007-09-25

10.1016/j.jmb.2007.03.007

A 2D representation of the interactions of NAG in 2J4Y
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	8.77	2	Yes	No	7	6	1	2
R:R:T4	R:R:V20	14.28	2	No	No	6	6	2	2
R:R:G18	R:R:N15	5.09	0	No	Yes	3	7	2	1
R:R:N15	R:R:V20	8.87	2	Yes	No	7	6	1	2
H:H:?2	R:R:N15	22.05	0	No	Yes	0	7	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	22.05
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

2PED

Sensory

Opsins

Rhodopsin

Bos taurus

9-cis-Retinal

2.95

2007-10-30

10.1529/biophysj.107.108225

A 2D representation of the interactions of NAG in 2PED
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	8.77	1	Yes	No	7	6	1	1
R:R:T4	R:R:V20	11.11	1	No	Yes	6	6	1	1
H:H:?6	R:R:T4	3.94	1	Yes	No	0	6	0	1
R:R:V11	R:R:V20	4.81	0	No	Yes	8	6	2	1
R:R:F13	R:R:V20	5.24	1	No	Yes	4	6	2	1
R:R:F13	R:R:Y30	6.19	1	No	Yes	4	4	2	2
R:R:G18	R:R:N15	5.09	1	No	Yes	3	7	1	1
R:R:N15	R:R:V20	13.3	1	Yes	Yes	7	6	1	1
H:H:?6	R:R:N15	29.4	1	Yes	Yes	0	7	0	1
H:H:?6	R:R:G18	7.63	1	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	10.09	1	Yes	Yes	6	4	1	2
H:H:?6	R:R:V20	9.3	1	Yes	Yes	0	6	0	1
H:H:?6	H:H:?7	46.25	1	Yes	No	0	0	0	1
H:H:?7	H:H:?8	26.89	0	No	No	0	0	1	2
H:H:?7	R:R:R21	3.25	0	No	No	0	4	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	19.30
Average Nodes In Shell	11.00
Average Hubs In Shell	4.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	13.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 2PED
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	8.77	1	Yes	No	7	6	2	2
R:R:T4	R:R:V20	11.11	1	No	Yes	6	6	2	2
H:H:?6	R:R:T4	3.94	1	Yes	No	0	6	1	2
R:R:G18	R:R:N15	5.09	1	No	Yes	3	7	2	2
R:R:N15	R:R:V20	13.3	1	Yes	Yes	7	6	2	2
H:H:?6	R:R:N15	29.4	1	Yes	Yes	0	7	1	2
H:H:?6	R:R:G18	7.63	1	Yes	No	0	3	1	2
H:H:?6	R:R:V20	9.3	1	Yes	Yes	0	6	1	2
R:R:A26	R:R:R21	6.91	0	No	No	2	4	2	1
H:H:?6	H:H:?7	46.25	1	Yes	No	0	0	1	0
H:H:?7	H:H:?8	26.89	0	No	No	0	0	0	1
H:H:?7	R:R:R21	3.25	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	25.46
Average Nodes In Shell	9.00
Average Hubs In Shell	3.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 2PED
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	14.81	10	No	No	2	6	1	1
H:H:?9	R:R:N2	28.17	10	Yes	No	0	6	0	1
H:H:?9	R:R:D282	7.26	10	Yes	No	0	2	0	1
H:H:?10	H:H:?9	34.14	0	No	Yes	0	0	1	0
R:R:H278	R:R:S281	2.79	0	No	No	3	4	2	1
H:H:?9	R:R:S281	2.68	10	Yes	No	0	4	0	1
H:H:?9	R:R:G280	1.53	10	Yes	No	0	1	0	1
H:H:?9	R:R:M1	1.26	10	Yes	No	0	6	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	12.51
Average Nodes In Shell	8.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 2PED
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	14.81	10	No	No	2	6	2	2
H:H:?9	R:R:N2	28.17	10	Yes	No	0	6	1	2
H:H:?9	R:R:D282	7.26	10	Yes	No	0	2	1	2
H:H:?10	H:H:?9	34.14	0	No	Yes	0	0	0	1
H:H:?9	R:R:S281	2.68	10	Yes	No	0	4	1	2
H:H:?9	R:R:G280	1.53	10	Yes	No	0	1	1	2
H:H:?9	R:R:M1	1.26	10	Yes	No	0	6	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	34.14
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

2X72

Sensory

Opsins

Rhodopsin

Bos taurus

All-trans-retinal

Gt(CT)

2011-03-16

10.1038/nature09795

A 2D representation of the interactions of NAG in 2X72
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	8.77	1	Yes	No	7	6	1	1
R:R:T4	R:R:V20	12.69	1	No	Yes	6	6	1	1
H:H:?1	R:R:T4	6.57	1	Yes	No	0	6	0	1
R:R:V11	R:R:V20	4.81	0	Yes	Yes	8	6	2	1
R:R:F13	R:R:V20	3.93	1	No	Yes	4	6	2	1
R:R:F13	R:R:Y30	11.35	1	No	No	4	4	2	2
R:R:G18	R:R:N15	3.39	1	No	Yes	3	7	1	1
R:R:N15	R:R:V20	10.35	1	Yes	Yes	7	6	1	1
H:H:?1	R:R:N15	24.5	1	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	8.83	1	Yes	No	6	4	1	2
H:H:?1	R:R:V20	6.64	1	Yes	Yes	0	6	0	1
H:H:?1	R:R:R21	6.5	1	Yes	No	0	4	0	1
H:H:?2	R:R:R21	8.67	1	Yes	No	0	4	1	1
H:H:?1	H:H:?2	39.65	1	Yes	Yes	0	0	0	1
H:H:?2	H:H:?3	30.74	1	Yes	No	0	0	1	2
H:H:?2	H:H:?5	11.43	1	Yes	No	0	0	1	2
H:H:?3	H:H:?5	28.05	1	No	No	0	0	2	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	14.99
Average Nodes In Shell	13.00
Average Hubs In Shell	5.00
Average Links In Shell	19.00
Average Links Mediated by Hubs In Shell	16.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 2X72
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	8.77	1	Yes	No	7	6	2	2
R:R:T4	R:R:V20	12.69	1	No	Yes	6	6	2	2
H:H:?1	R:R:T4	6.57	1	Yes	No	0	6	1	2
R:R:G18	R:R:N15	3.39	1	No	Yes	3	7	2	2
R:R:N15	R:R:V20	10.35	1	Yes	Yes	7	6	2	2
H:H:?1	R:R:N15	24.5	1	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	1	2
H:H:?1	R:R:V20	6.64	1	Yes	Yes	0	6	1	2
H:H:?1	R:R:R21	6.5	1	Yes	No	0	4	1	1
H:H:?2	R:R:R21	8.67	1	Yes	No	0	4	0	1
H:H:?1	H:H:?2	39.65	1	Yes	Yes	0	0	1	0
H:H:?2	H:H:?3	30.74	1	Yes	No	0	0	0	1
H:H:?2	H:H:?5	11.43	1	Yes	No	0	0	0	1
H:H:?3	H:H:?4	47.24	1	No	No	0	0	1	2
H:H:?3	H:H:?5	28.05	1	No	No	0	0	1	1
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	22.62
Average Nodes In Shell	11.00
Average Hubs In Shell	4.00
Average Links In Shell	16.00
Average Links Mediated by Hubs In Shell	13.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

3C9L

Sensory

Opsins

Rhodopsin

Bos taurus

11-cis-Retinal

2.65

2008-08-05

10.1107/S0907444908017162

A 2D representation of the interactions of NAG in 3C9L
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	5.85	2	Yes	No	7	6	1	2
R:R:T4	R:R:V20	12.69	2	No	Yes	6	6	2	2
R:R:G18	R:R:N15	5.09	2	No	Yes	3	7	1	1
R:R:N15	R:R:V20	10.35	2	Yes	Yes	7	6	1	2
H:H:?1	R:R:N15	24.5	2	No	Yes	0	7	0	1
H:H:?1	R:R:G18	7.63	2	No	No	0	3	0	1
H:H:?2	R:R:R21	5.42	0	No	No	0	4	1	2
H:H:?1	H:H:?2	28.63	2	No	No	0	0	0	1
H:H:?2	H:H:?3	32.02	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	20.25
Average Nodes In Shell	8.00
Average Hubs In Shell	2.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 3C9L
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:G18	R:R:N15	5.09	2	No	Yes	3	7	2	2
H:H:?1	R:R:N15	24.5	2	No	Yes	0	7	1	2
H:H:?1	R:R:G18	7.63	2	No	No	0	3	1	2
R:R:E25	R:R:R21	8.14	0	No	No	7	4	2	1
H:H:?2	R:R:R21	5.42	0	No	No	0	4	0	1
H:H:?1	H:H:?2	28.63	2	No	No	0	0	1	0
H:H:?2	H:H:?3	32.02	0	No	No	0	0	0	1
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	22.02
Average Nodes In Shell	8.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	2.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 3C9L
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	16.16	4	No	No	2	6	1	1
H:H:?4	R:R:N2	29.4	4	No	No	0	6	0	1
H:H:?4	R:R:D282	9.68	4	No	No	0	2	0	1
H:H:?4	H:H:?5	38.55	4	No	No	0	0	0	1
H:H:?5	H:H:?6	28.17	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	25.88
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 3C9L
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	16.16	4	No	No	2	6	2	2
H:H:?4	R:R:N2	29.4	4	No	No	0	6	1	2
H:H:?4	R:R:D282	9.68	4	No	No	0	2	1	2
H:H:?4	H:H:?5	38.55	4	No	No	0	0	1	0
H:H:?5	H:H:?6	28.17	0	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	33.36
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

3C9M

Sensory

Opsins

Rhodopsin

Bos taurus

11-cis-Retinal

3.4

2008-08-05

10.1107/S0907444908017162

A 2D representation of the interactions of NAG in 3C9M
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	7.31	1	Yes	No	7	6	1	1
R:R:T4	R:R:V20	12.69	1	No	Yes	6	6	1	2
H:H:?1	R:R:T4	3.94	1	No	No	0	6	0	1
R:R:G18	R:R:N15	5.09	0	No	Yes	3	7	2	1
R:R:N15	R:R:V20	10.35	1	Yes	Yes	7	6	1	2
H:H:?1	R:R:N15	24.5	1	No	Yes	0	7	0	1
R:R:E25	R:R:R21	8.14	0	No	No	7	4	2	1
H:H:?1	R:R:R21	4.33	1	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	10.92
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

3CAP

Sensory

Opsins

Rhodopsin

Bos taurus

2.9

2008-06-24

10.1038/nature07063

A 2D representation of the interactions of NAG in 3CAP
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	5.85	1	Yes	No	7	6	1	2
R:R:T4	R:R:V20	12.69	1	No	Yes	6	6	2	1
R:R:V11	R:R:V20	4.81	1	Yes	Yes	8	6	2	1
R:R:V11	R:R:Y30	5.05	1	Yes	Yes	8	4	2	2
R:R:G18	R:R:N15	5.09	1	No	Yes	3	7	1	1
R:R:N15	R:R:V20	10.35	1	Yes	Yes	7	6	1	1
H:H:?1	R:R:N15	26.95	1	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	11.36	1	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	7.97	1	Yes	Yes	0	6	0	1
H:H:?1	R:R:R21	4.33	1	Yes	No	0	4	0	1
H:H:?2	R:R:R21	8.67	1	No	No	0	4	1	1
H:H:?1	H:H:?2	37.44	1	Yes	No	0	0	0	1
H:H:?2	H:H:?3	32.02	1	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	16.56
Average Nodes In Shell	11.00
Average Hubs In Shell	5.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 3CAP
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:G18	R:R:N15	5.09	1	No	Yes	3	7	2	2
R:R:N15	R:R:V20	10.35	1	Yes	Yes	7	6	2	2
H:H:?1	R:R:N15	26.95	1	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	1	2
H:H:?1	R:R:V20	7.97	1	Yes	Yes	0	6	1	2
H:H:?1	R:R:R21	4.33	1	Yes	No	0	4	1	1
H:H:?2	R:R:R21	8.67	1	No	No	0	4	0	1
H:H:?1	H:H:?2	37.44	1	Yes	No	0	0	1	0
H:H:?2	H:H:?3	32.02	1	No	No	0	0	0	1
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	26.04
Average Nodes In Shell	8.00
Average Hubs In Shell	3.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 3CAP
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?4	R:R:M1	3.78	7	Yes	No	0	6	0	1
R:R:D282	R:R:N2	18.85	7	No	No	2	6	1	1
H:H:?4	R:R:N2	36.74	7	Yes	No	0	6	0	1
H:H:?4	R:R:D282	12.11	7	Yes	No	0	2	0	1
H:H:?4	H:H:?5	36.34	7	Yes	No	0	0	0	1
H:H:?4	R:R:S281	1.34	7	Yes	No	0	4	0	1
R:R:F283	R:R:S281	1.32	0	Yes	No	4	4	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.06
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 3CAP
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?4	R:R:M1	3.78	7	Yes	No	0	6	1	2
R:R:D282	R:R:N2	18.85	7	No	No	2	6	2	2
H:H:?4	R:R:N2	36.74	7	Yes	No	0	6	1	2
H:H:?4	R:R:D282	12.11	7	Yes	No	0	2	1	2
H:H:?4	H:H:?5	36.34	7	Yes	No	0	0	1	0
H:H:?4	R:R:S281	1.34	7	Yes	No	0	4	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	36.34
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

3CAP_poly

Sensory

Opsins

Rhodopsin

Bos taurus

2.9

2008-06-24

10.1038/nature07063

A 2D representation of the interactions of NAG in 3CAP_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	5.85	2	Yes	No	7	6	1	2
R:R:T4	R:R:V20	12.69	2	No	Yes	6	6	2	1
R:R:V11	R:R:V20	4.81	2	Yes	Yes	8	6	2	1
R:R:V11	R:R:Y30	5.05	2	Yes	Yes	8	4	2	2
R:R:G18	R:R:N15	5.09	2	No	Yes	3	7	1	1
R:R:N15	R:R:V20	10.35	2	Yes	Yes	7	6	1	1
H:H:?1	R:R:N15	26.95	2	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	11.36	2	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	7.97	2	Yes	Yes	0	6	0	1
H:H:?1	R:R:R21	4.33	2	Yes	No	0	4	0	1
H:H:?2	R:R:R21	8.67	2	No	No	0	4	1	1
H:H:?1	H:H:?2	37.44	2	Yes	No	0	0	0	1
H:H:?2	H:H:?3	32.02	2	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	16.56
Average Nodes In Shell	11.00
Average Hubs In Shell	5.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 3CAP_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:G18	R:R:N15	5.09	2	No	Yes	3	7	2	2
R:R:N15	R:R:V20	10.35	2	Yes	Yes	7	6	2	2
H:H:?1	R:R:N15	26.95	2	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	1	2
H:H:?1	R:R:V20	7.97	2	Yes	Yes	0	6	1	2
H:H:?1	R:R:R21	4.33	2	Yes	No	0	4	1	1
H:H:?2	R:R:R21	8.67	2	No	No	0	4	0	1
H:H:?1	H:H:?2	37.44	2	Yes	No	0	0	1	0
H:H:?2	H:H:?3	32.02	2	No	No	0	0	0	1
H:H:?3	H:H:?4	40.21	0	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	26.04
Average Nodes In Shell	9.00
Average Hubs In Shell	3.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 3CAP_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?5	R:R:M1	3.78	12	Yes	No	0	6	0	1
R:R:D282	R:R:N2	18.85	12	No	No	2	6	1	1
H:H:?5	R:R:N2	36.74	12	Yes	No	0	6	0	1
H:H:?5	R:R:D282	12.11	12	Yes	No	0	2	0	1
H:H:?5	H:H:?6	36.34	12	Yes	No	0	0	0	1
H:H:?5	R:R:S281	1.34	12	Yes	No	0	4	0	1
R:R:F283	R:R:S281	1.32	0	Yes	No	4	4	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.06
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 3CAP_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?5	R:R:M1	3.78	12	Yes	No	0	6	1	2
R:R:D282	R:R:N2	18.85	12	No	No	2	6	2	2
H:H:?5	R:R:N2	36.74	12	Yes	No	0	6	1	2
H:H:?5	R:R:D282	12.11	12	Yes	No	0	2	1	2
H:H:?5	H:H:?6	36.34	12	Yes	No	0	0	1	0
H:H:?5	R:R:S281	1.34	12	Yes	No	0	4	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	36.34
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 3CAP_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N15	S:S:T4	4.39	1	Yes	No	7	6	1	1
S:S:T4	S:S:V20	12.69	1	No	Yes	6	6	1	2
H:H:?7	S:S:T4	3.94	1	Yes	No	0	6	0	1
S:S:G18	S:S:N15	5.09	1	No	Yes	3	7	1	1
S:S:N15	S:S:V20	10.35	1	Yes	Yes	7	6	1	2
H:H:?7	S:S:N15	26.95	1	Yes	Yes	0	7	0	1
H:H:?7	S:S:G18	6.1	1	Yes	No	0	3	0	1
H:H:?7	S:S:R21	3.25	1	Yes	No	0	4	0	1
H:H:?8	S:S:R21	5.42	1	No	No	0	4	1	1
H:H:?7	H:H:?8	38.55	1	Yes	No	0	0	0	1
H:H:?8	H:H:?9	32.02	1	No	No	0	0	1	2
S:S:A26	S:S:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	15.76
Average Nodes In Shell	9.00
Average Hubs In Shell	3.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 3CAP_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N15	S:S:T4	4.39	1	Yes	No	7	6	2	2
H:H:?7	S:S:T4	3.94	1	Yes	No	0	6	1	2
S:S:G18	S:S:N15	5.09	1	No	Yes	3	7	2	2
H:H:?7	S:S:N15	26.95	1	Yes	Yes	0	7	1	2
H:H:?7	S:S:G18	6.1	1	Yes	No	0	3	1	2
H:H:?7	S:S:R21	3.25	1	Yes	No	0	4	1	1
H:H:?8	S:S:R21	5.42	1	No	No	0	4	0	1
H:H:?7	H:H:?8	38.55	1	Yes	No	0	0	1	0
H:H:?8	H:H:?9	32.02	1	No	No	0	0	0	1
H:H:?10	H:H:?9	49.14	0	No	No	0	0	2	1
S:S:A26	S:S:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	25.33
Average Nodes In Shell	9.00
Average Hubs In Shell	2.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 3CAP_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?11	S:S:M1	3.78	20	Yes	No	0	6	0	1
S:S:D282	S:S:N2	20.2	20	No	No	2	6	1	1
H:H:?11	S:S:N2	34.3	20	Yes	No	0	6	0	1
H:H:?12	S:S:S281	4.02	0	No	No	0	4	1	2
H:H:?11	S:S:D282	9.68	20	Yes	No	0	2	0	1
H:H:?11	H:H:?12	35.24	20	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	20.75
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 3CAP_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?11	S:S:M1	3.78	20	Yes	No	0	6	1	2
S:S:D282	S:S:N2	20.2	20	No	No	2	6	2	2
H:H:?11	S:S:N2	34.3	20	Yes	No	0	6	1	2
H:H:?12	S:S:S281	4.02	0	No	No	0	4	0	1
H:H:?11	S:S:D282	9.68	20	Yes	No	0	2	1	2
H:H:?11	H:H:?12	35.24	20	Yes	No	0	0	1	0
S:S:F283	S:S:S281	1.32	0	Yes	No	4	4	2	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	19.63
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

3DQB

Sensory

Opsins

Rhodopsin

Bos taurus

Gt(CT)

3.2

2008-09-23

10.1038/nature07330

A 2D representation of the interactions of NAG in 3DQB
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	5.85	2	Yes	No	7	6	1	1
R:R:T4	R:R:V20	12.69	2	No	Yes	6	6	1	2
H:H:?1	R:R:T4	5.26	2	Yes	No	0	6	0	1
R:R:G18	R:R:N15	5.09	2	No	Yes	3	7	1	1
R:R:N15	R:R:V20	10.35	2	Yes	Yes	7	6	1	2
H:H:?1	R:R:N15	26.95	2	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	0	1
H:H:?1	R:R:R21	4.33	2	Yes	No	0	4	0	1
H:H:?2	R:R:R21	7.59	2	No	No	0	4	1	1
H:H:?1	H:H:?2	35.24	2	Yes	No	0	0	0	1
H:H:?2	H:H:?3	33.3	2	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	15.58
Average Nodes In Shell	9.00
Average Hubs In Shell	3.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 3DQB
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	5.85	2	Yes	No	7	6	2	2
H:H:?1	R:R:T4	5.26	2	Yes	No	0	6	1	2
R:R:G18	R:R:N15	5.09	2	No	Yes	3	7	2	2
H:H:?1	R:R:N15	26.95	2	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	1	2
H:H:?1	R:R:R21	4.33	2	Yes	No	0	4	1	1
H:H:?2	R:R:R21	7.59	2	No	No	0	4	0	1
H:H:?1	H:H:?2	35.24	2	Yes	No	0	0	1	0
H:H:?2	H:H:?3	33.3	2	No	No	0	0	0	1
H:H:?3	H:H:?8	31	0	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	25.38
Average Nodes In Shell	9.00
Average Hubs In Shell	2.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 3DQB
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	20.2	6	No	No	2	6	1	1
H:H:?4	R:R:N2	22.05	6	Yes	No	0	6	0	1
H:H:?4	R:R:D282	15.74	6	Yes	No	0	2	0	1
H:H:?4	H:H:?5	28.63	6	Yes	No	0	0	0	1
R:R:H278	R:R:S281	2.79	0	No	No	3	4	2	1
H:H:?4	R:R:S281	1.34	6	Yes	No	0	4	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	16.94
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 3DQB
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	20.2	6	No	No	2	6	2	2
H:H:?4	R:R:N2	22.05	6	Yes	No	0	6	1	2
H:H:?4	R:R:D282	15.74	6	Yes	No	0	2	1	2
H:H:?4	H:H:?5	28.63	6	Yes	No	0	0	1	0
H:H:?4	R:R:S281	1.34	6	Yes	No	0	4	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	28.63
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

3OAX

Sensory

Opsins

Rhodopsin

Bos taurus

11-cis-Retinal

2.6

2011-01-19

10.1016/j.bpj.2010.08.003

A 2D representation of the interactions of NAG in 3OAX
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	5.85	1	Yes	No	7	6	1	1
R:R:T4	R:R:V20	12.69	1	No	Yes	6	6	1	2
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	0	1
R:R:G18	R:R:N15	5.09	1	No	Yes	3	7	1	1
R:R:N15	R:R:V20	10.35	1	Yes	Yes	7	6	1	2
H:H:?1	R:R:N15	23.27	1	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	0	1
H:H:?1	H:H:?2	41.85	1	Yes	No	0	0	0	1
H:H:?2	H:H:?3	28.17	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	19.12
Average Nodes In Shell	7.00
Average Hubs In Shell	3.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 3OAX
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	5.85	1	Yes	No	7	6	2	2
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	1	2
R:R:G18	R:R:N15	5.09	1	No	Yes	3	7	2	2
H:H:?1	R:R:N15	23.27	1	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	1	2
H:H:?1	H:H:?2	41.85	1	Yes	No	0	0	1	0
H:H:?2	H:H:?3	28.17	0	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	35.01
Average Nodes In Shell	6.00
Average Hubs In Shell	2.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 3OAX
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	14.81	7	No	No	2	6	1	1
H:H:?4	R:R:N2	26.95	7	Yes	No	0	6	0	1
R:R:H278	R:R:S281	4.18	0	No	No	3	4	2	1
H:H:?4	R:R:D282	6.05	7	Yes	No	0	2	0	1
H:H:?4	H:H:?5	38.55	7	Yes	No	0	0	0	1
H:H:?4	R:R:S281	2.68	7	Yes	No	0	4	0	1
H:H:?4	R:R:M1	1.26	7	Yes	No	0	6	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.10
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 3OAX
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	14.81	7	No	No	2	6	2	2
H:H:?4	R:R:N2	26.95	7	Yes	No	0	6	1	2
H:H:?4	R:R:D282	6.05	7	Yes	No	0	2	1	2
H:H:?4	H:H:?5	38.55	7	Yes	No	0	0	1	0
H:H:?4	R:R:S281	2.68	7	Yes	No	0	4	1	2
H:H:?4	R:R:M1	1.26	7	Yes	No	0	6	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	38.55
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

3PQR

Sensory

Opsins

Rhodopsin

Bos taurus

All-trans-retinal

Gt(CT)

2.85

2011-03-09

10.1038/nature09789

A 2D representation of the interactions of NAG in 3PQR
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	7.31	2	Yes	No	7	6	1	1
R:R:T4	R:R:V20	12.69	2	No	Yes	6	6	1	1
H:H:?1	R:R:T4	5.26	2	Yes	No	0	6	0	1
R:R:V11	R:R:V20	4.81	2	Yes	Yes	8	6	2	1
R:R:V11	R:R:Y30	5.05	2	Yes	Yes	8	4	2	2
R:R:G18	R:R:N15	5.09	2	No	Yes	3	7	1	1
R:R:N15	R:R:V20	10.35	2	Yes	Yes	7	6	1	1
H:H:?1	R:R:N15	25.72	2	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	12.62	2	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	3.99	2	Yes	Yes	0	6	0	1
H:H:?2	R:R:R21	6.5	0	No	No	0	4	1	2
H:H:?1	H:H:?2	38.55	2	Yes	No	0	0	0	1
H:H:?2	H:H:?3	25.61	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	15.92
Average Nodes In Shell	10.00
Average Hubs In Shell	5.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 3PQR
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	7.31	2	Yes	No	7	6	2	2
R:R:T4	R:R:V20	12.69	2	No	Yes	6	6	2	2
H:H:?1	R:R:T4	5.26	2	Yes	No	0	6	1	2
R:R:G18	R:R:N15	5.09	2	No	Yes	3	7	2	2
R:R:N15	R:R:V20	10.35	2	Yes	Yes	7	6	2	2
H:H:?1	R:R:N15	25.72	2	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	1	2
H:H:?1	R:R:V20	3.99	2	Yes	Yes	0	6	1	2
H:H:?2	R:R:R21	6.5	0	No	No	0	4	0	1
H:H:?1	H:H:?2	38.55	2	Yes	No	0	0	1	0
H:H:?2	H:H:?3	25.61	0	No	No	0	0	0	1
H:H:?3	H:H:?6	39.86	0	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	23.55
Average Nodes In Shell	10.00
Average Hubs In Shell	3.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 3PQR
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	13.46	5	No	No	2	6	1	1
H:H:?4	R:R:N2	29.4	5	No	No	0	6	0	1
H:H:?4	R:R:D282	21.79	5	No	No	0	2	0	1
R:R:G280	R:R:S281	1.86	0	No	No	1	4	1	2
H:H:?4	R:R:G280	1.53	5	No	No	0	1	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	17.57
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

3PXO

Sensory

Opsins

Rhodopsin

Bos taurus

All-trans-retinal

2011-03-09

10.1038/nature09789

A 2D representation of the interactions of NAG in 3PXO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	7.31	1	Yes	No	7	6	1	1
R:R:T4	R:R:V20	11.11	1	No	Yes	6	6	1	1
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	0	1
R:R:V11	R:R:V20	4.81	0	No	Yes	8	6	2	1
R:R:G18	R:R:N15	5.09	1	No	Yes	3	7	1	1
R:R:N15	R:R:V20	10.35	1	Yes	Yes	7	6	1	1
H:H:?1	R:R:N15	26.95	1	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	12.62	1	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	3.99	1	Yes	Yes	0	6	0	1
H:H:?2	R:R:R21	6.5	0	No	No	0	4	1	2
H:H:?1	H:H:?2	36.34	1	Yes	No	0	0	0	1
H:H:?2	H:H:?3	28.17	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	15.73
Average Nodes In Shell	10.00
Average Hubs In Shell	4.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 3PXO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	7.31	1	Yes	No	7	6	2	2
R:R:T4	R:R:V20	11.11	1	No	Yes	6	6	2	2
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	1	2
R:R:G18	R:R:N15	5.09	1	No	Yes	3	7	2	2
R:R:N15	R:R:V20	10.35	1	Yes	Yes	7	6	2	2
H:H:?1	R:R:N15	26.95	1	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	1	2
H:H:?1	R:R:V20	3.99	1	Yes	Yes	0	6	1	2
H:H:?2	R:R:R21	6.5	0	No	No	0	4	0	1
H:H:?1	H:H:?2	36.34	1	Yes	No	0	0	1	0
H:H:?2	H:H:?3	28.17	0	No	No	0	0	0	1
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	23.67
Average Nodes In Shell	9.00
Average Hubs In Shell	3.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 3PXO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	18.85	6	No	No	2	6	1	1
H:H:?4	R:R:N2	36.74	6	No	No	0	6	0	1
H:H:?4	R:R:D282	12.11	6	No	No	0	2	0	1
H:H:?4	H:H:?5	40.75	6	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	29.87
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 3PXO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	18.85	6	No	No	2	6	2	2
H:H:?4	R:R:N2	36.74	6	No	No	0	6	1	2
H:H:?4	R:R:D282	12.11	6	No	No	0	2	1	2
H:H:?4	H:H:?5	40.75	6	No	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	40.75
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

3V2W

Lipid

Lysophospholipid (S1P)

S1P1

Homo sapiens

PubChem 51892645

3.35

2012-02-15

10.1126/science.1215904

A 2D representation of the interactions of NAG in 3V2W
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L35	R:R:N30	5.49	0	Yes	No	6	9	2	1
H:H:?1	R:R:N30	28.17	0	No	No	0	9	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	28.17
Average Nodes In Shell	3.00
Average Hubs In Shell	1.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

3V2Y

Lipid

Lysophospholipid (S1P)

S1P1

Homo sapiens

PubChem 51892645

2.8

2012-02-15

10.1126/science.1215904

A 2D representation of the interactions of NAG in 3V2Y
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L35	R:R:N30	6.87	0	No	No	6	9	2	1
H:H:?1	R:R:N30	31.85	0	No	No	0	9	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	31.85
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

4A4M

Sensory

Opsins

Rhodopsin

Bos taurus

All-trans-retinal

Gt(CT)

3.3

2012-01-25

10.1073/pnas.1114089108

A 2D representation of the interactions of NAG in 4A4M
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:T4	R:R:V11	4.76	1	No	No	6	8	1	2
R:R:T4	R:R:V20	12.69	1	No	Yes	6	6	1	1
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	0	1
R:R:V11	R:R:V20	4.81	1	No	Yes	8	6	2	1
R:R:F13	R:R:V20	3.93	1	No	Yes	4	6	2	1
R:R:F13	R:R:Y30	12.38	1	No	Yes	4	4	2	2
R:R:G18	R:R:N15	5.09	1	No	No	3	7	1	1
R:R:N15	R:R:V20	13.3	1	No	Yes	7	6	1	1
H:H:?1	R:R:N15	29.4	1	Yes	No	0	7	0	1
H:H:?1	R:R:G18	7.63	1	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	7.57	1	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	6.64	1	Yes	Yes	0	6	0	1
H:H:?1	R:R:R21	7.59	1	Yes	No	0	4	0	1
H:H:?2	R:R:R21	9.75	1	No	No	0	4	1	1
H:H:?1	H:H:?2	35.24	1	Yes	No	0	0	0	1
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	15.29
Average Nodes In Shell	11.00
Average Hubs In Shell	3.00
Average Links In Shell	16.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 4A4M
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:T4	R:R:V20	12.69	1	No	Yes	6	6	2	2
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	1	2
R:R:G18	R:R:N15	5.09	1	No	No	3	7	2	2
R:R:N15	R:R:V20	13.3	1	No	Yes	7	6	2	2
H:H:?1	R:R:N15	29.4	1	Yes	No	0	7	1	2
H:H:?1	R:R:G18	7.63	1	Yes	No	0	3	1	2
H:H:?1	R:R:V20	6.64	1	Yes	Yes	0	6	1	2
H:H:?1	R:R:R21	7.59	1	Yes	No	0	4	1	1
H:H:?2	R:R:R21	9.75	1	No	No	0	4	0	1
H:H:?1	H:H:?2	35.24	1	Yes	No	0	0	1	0
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	22.50
Average Nodes In Shell	8.00
Average Hubs In Shell	2.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

4BEY

Sensory

Opsins

Rhodopsin

Bos taurus

Gt(CT)

2.9

2013-05-08

10.1038/embor.2013.44

A 2D representation of the interactions of NAG in 4BEY
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	5.85	1	No	No	7	6	1	1
R:R:T4	R:R:V20	9.52	1	No	Yes	6	6	1	1
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	0	1
R:R:V11	R:R:V20	4.81	1	No	Yes	8	6	2	1
R:R:F13	R:R:V20	5.24	1	No	Yes	4	6	2	1
R:R:F13	R:R:Y30	11.35	1	No	Yes	4	4	2	2
R:R:N15	R:R:V20	10.35	1	No	Yes	7	6	1	1
H:H:?1	R:R:N15	25.72	1	Yes	No	0	7	0	1
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	12.62	1	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	5.32	1	Yes	Yes	0	6	0	1
H:H:?1	R:R:R21	5.42	1	Yes	No	0	4	0	1
H:H:?2	R:R:R21	8.67	1	No	No	0	4	1	1
H:H:?1	H:H:?2	37.44	1	Yes	No	0	0	0	1
H:H:?2	H:H:?3	30.74	1	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	14.21
Average Nodes In Shell	12.00
Average Hubs In Shell	3.00
Average Links In Shell	16.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 4BEY
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	5.85	1	No	No	7	6	2	2
R:R:T4	R:R:V20	9.52	1	No	Yes	6	6	2	2
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	1	2
R:R:N15	R:R:V20	10.35	1	No	Yes	7	6	2	2
H:H:?1	R:R:N15	25.72	1	Yes	No	0	7	1	2
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	1	2
H:H:?1	R:R:V20	5.32	1	Yes	Yes	0	6	1	2
H:H:?1	R:R:R21	5.42	1	Yes	No	0	4	1	1
H:H:?2	R:R:R21	8.67	1	No	No	0	4	0	1
H:H:?1	H:H:?2	37.44	1	Yes	No	0	0	1	0
H:H:?2	H:H:?3	30.74	1	No	No	0	0	0	1
H:H:?3	H:H:?5	48.72	0	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	25.62
Average Nodes In Shell	10.00
Average Hubs In Shell	2.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

4BEZ

Sensory

Opsins

Rhodopsin

Bos taurus

3.3

2013-04-24

10.1038/embor.2013.44

A 2D representation of the interactions of NAG in 4BEZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	4.39	1	No	No	7	6	1	1
R:R:T4	R:R:V20	9.52	1	No	Yes	6	6	1	1
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	0	1
R:R:V11	R:R:V20	4.81	1	No	Yes	8	6	2	1
R:R:F13	R:R:V20	5.24	1	No	Yes	4	6	2	1
R:R:F13	R:R:Y30	13.41	1	No	Yes	4	4	2	2
R:R:N15	R:R:V20	10.35	1	No	Yes	7	6	1	1
H:H:?1	R:R:N15	28.17	1	Yes	No	0	7	0	1
H:H:?1	R:R:G18	7.63	1	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	12.62	1	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	7.97	1	Yes	Yes	0	6	0	1
H:H:?1	R:R:R21	6.5	1	Yes	No	0	4	0	1
H:H:?2	R:R:R21	7.59	1	No	No	0	4	1	1
H:H:?1	H:H:?2	37.44	1	Yes	No	0	0	0	1
H:H:?2	H:H:?3	34.58	1	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	15.49
Average Nodes In Shell	12.00
Average Hubs In Shell	3.00
Average Links In Shell	16.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 4BEZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	4.39	1	No	No	7	6	2	2
R:R:T4	R:R:V20	9.52	1	No	Yes	6	6	2	2
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	1	2
R:R:N15	R:R:V20	10.35	1	No	Yes	7	6	2	2
H:H:?1	R:R:N15	28.17	1	Yes	No	0	7	1	2
H:H:?1	R:R:G18	7.63	1	Yes	No	0	3	1	2
H:H:?1	R:R:V20	7.97	1	Yes	Yes	0	6	1	2
H:H:?1	R:R:R21	6.5	1	Yes	No	0	4	1	1
H:H:?2	R:R:R21	7.59	1	No	No	0	4	0	1
H:H:?1	H:H:?2	37.44	1	Yes	No	0	0	1	0
H:H:?2	H:H:?3	34.58	1	No	No	0	0	0	1
H:H:?3	H:H:?5	44.29	0	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	26.54
Average Nodes In Shell	10.00
Average Hubs In Shell	2.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

4J4Q

Sensory

Opsins

Rhodopsin

Bos taurus

Octyl Beta-D-Glucopyranoside

Gt(CT)

2.65

2013-10-30

10.1002/anie.201302374

A 2D representation of the interactions of NAG in 4J4Q
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	8.77	4	Yes	No	7	6	1	1
R:R:T4	R:R:V20	9.52	4	No	Yes	6	6	1	1
H:H:?1	R:R:T4	5.26	4	Yes	No	0	6	0	1
R:R:V11	R:R:V20	4.81	0	No	Yes	8	6	2	1
R:R:G18	R:R:N15	5.09	4	No	Yes	3	7	1	1
R:R:N15	R:R:V20	10.35	4	Yes	Yes	7	6	1	1
H:H:?1	R:R:N15	24.5	4	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	6.1	4	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	12.62	4	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	5.32	4	Yes	Yes	0	6	0	1
H:H:?2	R:R:R21	6.5	0	No	No	0	4	1	2
H:H:?1	H:H:?2	33.04	4	Yes	No	0	0	0	1
H:H:?2	H:H:?3	28.17	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	14.84
Average Nodes In Shell	10.00
Average Hubs In Shell	4.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 4J4Q
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	8.77	4	Yes	No	7	6	2	2
R:R:T4	R:R:V20	9.52	4	No	Yes	6	6	2	2
H:H:?1	R:R:T4	5.26	4	Yes	No	0	6	1	2
R:R:G18	R:R:N15	5.09	4	No	Yes	3	7	2	2
R:R:N15	R:R:V20	10.35	4	Yes	Yes	7	6	2	2
H:H:?1	R:R:N15	24.5	4	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	6.1	4	Yes	No	0	3	1	2
H:H:?1	R:R:V20	5.32	4	Yes	Yes	0	6	1	2
H:H:?2	R:R:R21	6.5	0	No	No	0	4	0	1
H:H:?1	H:H:?2	33.04	4	Yes	No	0	0	1	0
H:H:?2	H:H:?3	28.17	0	No	No	0	0	0	1
H:H:?3	H:H:?5	29.52	0	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	22.57
Average Nodes In Shell	10.00
Average Hubs In Shell	3.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

4N4W

Protein

Frizzled

SMO

Homo sapiens

SANT-1

2.8

2014-01-22

10.1038/ncomms5355

A 2D representation of the interactions of NAG in 4N4W
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?2	R:R:D209	7.26	No	No	4	1	2
H:H:?1	R:R:A492	4.22	No	No	5	0	1
H:H:?1	H:H:?2	26.43	No	No	0	0	1
H:H:?2	H:H:?3	28.17	No	No	0	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.32
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 4N4W
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?2	R:R:D209	7.26	No	No	0	4	0	1
H:H:?1	R:R:A492	4.22	No	No	0	5	1	2
H:H:?1	H:H:?2	26.43	No	No	0	0	1	0
H:H:?2	H:H:?3	28.17	No	No	0	0	0	1
H:H:?3	H:H:?4	29.52	No	No	0	0	1	2
R:R:D209	R:R:E208	2.6	No	No	4	4	1	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	20.62
Average Nodes In Shell	7.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

4PXF

Sensory

Opsins

Rhodopsin

Bos taurus

Octyl Beta-D-Glucopyranoside

Arrestin1_Finger_loop

2.75

2014-09-17

10.1038/ncomms5801

A 2D representation of the interactions of NAG in 4PXF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	7.31	2	No	No	7	6	1	1
R:R:T4	R:R:V20	12.69	2	No	Yes	6	6	1	1
H:H:?1	R:R:T4	5.26	2	Yes	No	0	6	0	1
R:R:V11	R:R:V20	4.81	2	Yes	Yes	8	6	2	1
R:R:N15	R:R:V20	10.35	2	No	Yes	7	6	1	1
H:H:?1	R:R:N15	28.17	2	Yes	No	0	7	0	1
H:H:?1	R:R:G18	7.63	2	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	12.62	2	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	6.64	2	Yes	Yes	0	6	0	1
H:H:?2	R:R:R21	5.42	0	No	No	0	4	1	2
H:H:?1	H:H:?2	37.44	2	Yes	No	0	0	0	1
H:H:?2	H:H:?3	29.45	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	17.03
Average Nodes In Shell	10.00
Average Hubs In Shell	4.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 4PXF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	7.31	2	No	No	7	6	2	2
R:R:T4	R:R:V20	12.69	2	No	Yes	6	6	2	2
H:H:?1	R:R:T4	5.26	2	Yes	No	0	6	1	2
R:R:N15	R:R:V20	10.35	2	No	Yes	7	6	2	2
H:H:?1	R:R:N15	28.17	2	Yes	No	0	7	1	2
H:H:?1	R:R:G18	7.63	2	Yes	No	0	3	1	2
H:H:?1	R:R:V20	6.64	2	Yes	Yes	0	6	1	2
H:H:?2	R:R:R21	5.42	0	No	No	0	4	0	1
H:H:?1	H:H:?2	37.44	2	Yes	No	0	0	1	0
H:H:?2	H:H:?3	29.45	0	No	No	0	0	0	1
H:H:?3	H:H:?5	36.91	0	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	24.10
Average Nodes In Shell	10.00
Average Hubs In Shell	2.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

4X1H

Sensory

Opsins

Rhodopsin

Bos taurus

Nonyl Beta-D-Glucopyranoside

Gt(CT)

2.29

2015-11-04

10.1016/j.str.2015.09.015

A 2D representation of the interactions of NAG in 4X1H
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	8.77	2	Yes	No	7	6	1	1
R:R:T4	R:R:V20	12.69	2	No	Yes	6	6	1	1
H:H:?1	R:R:T4	5.26	2	Yes	No	0	6	0	1
R:R:V11	R:R:V20	4.81	2	No	Yes	8	6	2	1
R:R:V11	R:R:Y30	5.05	2	No	Yes	8	4	2	2
R:R:F13	R:R:V20	3.93	2	No	Yes	4	6	2	1
R:R:F13	R:R:Y30	7.22	2	No	Yes	4	4	2	2
R:R:G18	R:R:N15	5.09	2	No	Yes	3	7	1	1
R:R:N15	R:R:V20	10.35	2	Yes	Yes	7	6	1	1
H:H:?1	R:R:N15	25.72	2	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	11.36	2	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	3.99	2	Yes	Yes	0	6	0	1
H:H:?2	R:R:R21	6.5	0	No	No	0	4	1	2
H:H:?1	H:H:?2	38.55	2	Yes	No	0	0	0	1
H:H:?2	H:H:?3	34.58	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	15.92
Average Nodes In Shell	11.00
Average Hubs In Shell	4.00
Average Links In Shell	16.00
Average Links Mediated by Hubs In Shell	14.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 4X1H
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	8.77	2	Yes	No	7	6	2	2
R:R:T4	R:R:V20	12.69	2	No	Yes	6	6	2	2
H:H:?1	R:R:T4	5.26	2	Yes	No	0	6	1	2
R:R:G18	R:R:N15	5.09	2	No	Yes	3	7	2	2
R:R:N15	R:R:V20	10.35	2	Yes	Yes	7	6	2	2
H:H:?1	R:R:N15	25.72	2	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	1	2
H:H:?1	R:R:V20	3.99	2	Yes	Yes	0	6	1	2
H:H:?2	R:R:R21	6.5	0	No	No	0	4	0	1
H:H:?1	H:H:?2	38.55	2	Yes	No	0	0	1	0
H:H:?2	H:H:?3	34.58	0	No	No	0	0	0	1
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	26.54
Average Nodes In Shell	9.00
Average Hubs In Shell	3.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 4X1H
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	21.54	5	No	No	2	6	1	1
H:H:?4	R:R:N2	30.62	5	No	No	0	6	0	1
H:H:?4	R:R:D282	14.53	5	No	No	0	2	0	1
H:H:?4	H:H:?5	38.55	5	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	27.90
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 4X1H
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	21.54	5	No	No	2	6	2	2
H:H:?4	R:R:N2	30.62	5	No	No	0	6	1	2
H:H:?4	R:R:D282	14.53	5	No	No	0	2	1	2
H:H:?4	H:H:?5	38.55	5	No	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	38.55
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

4XT3

Other

Unclassified

US28

Human cytomegalovirus (strain AD169)

Fractalkine

3.8

2015-03-04

10.1126/science.aaa5026

A 2D representation of the interactions of NAG in 4XT3
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
L:L:I34	R:R:V24	3.07	8	Yes	No	2	1	2
L:L:Q55	R:R:Q172	6.4	8	No	No	3	1	2
L:L:I34	L:L:N33	4.25	8	Yes	Yes	0	1	1
L:L:N33	L:L:Q55	6.6	8	Yes	No	0	1	1
H:H:?1	L:L:N33	23.27	8	Yes	Yes	0	0	1
L:L:I34	L:L:N54	4.25	8	Yes	No	0	1	2
L:L:I34	L:L:I64	7.36	8	Yes	No	0	1	2
H:H:?1	L:L:I34	6.37	8	Yes	Yes	0	0	1
H:H:?2	L:L:Q52	16.62	0	No	No	0	1	2
H:H:?1	L:L:Q55	7.12	8	Yes	No	0	0	1
H:H:?1	H:H:?2	48.46	8	Yes	No	0	0	1
H:H:?2	H:H:?3	38.55	0	No	No	0	1	2
L:L:N33	R:R:T26	2.92	8	Yes	No	4	1	2
L:L:N33	R:R:L29	1.37	8	Yes	No	3	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	21.30
Average Nodes In Shell	13.00
Average Hubs In Shell	3.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 4XT3
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
L:L:I34	L:L:N33	4.25	8	Yes	Yes	2	2
L:L:N33	L:L:Q55	6.6	8	Yes	No	2	2
H:H:?1	L:L:N33	23.27	8	Yes	Yes	1	2
H:H:?1	L:L:I34	6.37	8	Yes	Yes	1	2
H:H:?2	L:L:Q52	16.62	0	No	No	0	1
H:H:?1	L:L:Q55	7.12	8	Yes	No	1	2
H:H:?1	H:H:?2	48.46	8	Yes	No	1	0
H:H:?2	H:H:?3	38.55	0	No	No	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	34.54
Average Nodes In Shell	7.00
Average Hubs In Shell	3.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 4XT3
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
H:H:?2	L:L:Q52	16.62	0	No	No	1	2
H:H:?1	H:H:?2	48.46	8	Yes	No	2	1
H:H:?2	H:H:?3	38.55	0	No	No	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	38.55
Average Nodes In Shell	4.00
Average Hubs In Shell	1.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

5DYS

Sensory

Opsins

Rhodopsin

Bos taurus

All-trans-retinal

2.3

2016-08-10

10.15252/embr.201642671

A 2D representation of the interactions of NAG in 5DYS
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	7.31	1	Yes	No	7	6	1	1
R:R:T4	R:R:V20	12.69	1	No	Yes	6	6	1	2
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	0	1
R:R:G18	R:R:N15	5.09	1	No	Yes	3	7	1	1
R:R:N15	R:R:V20	10.35	1	Yes	Yes	7	6	1	2
H:H:?1	R:R:N15	24.5	1	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	0	1
H:H:?2	R:R:R21	6.5	0	No	No	0	4	1	2
H:H:?1	H:H:?2	37.44	1	Yes	No	0	0	0	1
H:H:?2	H:H:?3	28.17	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	18.32
Average Nodes In Shell	8.00
Average Hubs In Shell	3.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 5DYS
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	7.31	1	Yes	No	7	6	2	2
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	1	2
R:R:G18	R:R:N15	5.09	1	No	Yes	3	7	2	2
H:H:?1	R:R:N15	24.5	1	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	1	2
H:H:?2	R:R:R21	6.5	0	No	No	0	4	0	1
H:H:?1	H:H:?2	37.44	1	Yes	No	0	0	1	0
H:H:?2	H:H:?3	28.17	0	No	No	0	0	0	1
H:H:?3	H:H:?6	39.86	0	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	24.04
Average Nodes In Shell	9.00
Average Hubs In Shell	2.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

5EN0

Sensory

Opsins

Rhodopsin

Bos taurus

All-trans-retinal

Gt(CT)

2.81

2016-08-10

10.15252/embr.201642671

A 2D representation of the interactions of NAG in 5EN0
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	7.31	1	Yes	No	7	6	1	1
R:R:T4	R:R:V20	12.69	1	No	Yes	6	6	1	1
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	0	1
R:R:V11	R:R:V20	4.81	1	No	Yes	8	6	2	1
R:R:G18	R:R:N15	5.09	1	No	Yes	3	7	1	1
R:R:N15	R:R:V20	10.35	1	Yes	Yes	7	6	1	1
H:H:?1	R:R:N15	25.72	1	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	10.09	1	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	3.99	1	Yes	Yes	0	6	0	1
H:H:?1	R:R:R21	5.42	1	Yes	No	0	4	0	1
H:H:?2	R:R:R21	8.67	1	No	No	0	4	1	1
H:H:?1	H:H:?2	37.44	1	Yes	No	0	0	0	1
H:H:?2	H:H:?3	25.61	1	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	13.99
Average Nodes In Shell	11.00
Average Hubs In Shell	4.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 5EN0
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	7.31	1	Yes	No	7	6	2	2
R:R:T4	R:R:V20	12.69	1	No	Yes	6	6	2	2
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	1	2
R:R:G18	R:R:N15	5.09	1	No	Yes	3	7	2	2
R:R:N15	R:R:V20	10.35	1	Yes	Yes	7	6	2	2
H:H:?1	R:R:N15	25.72	1	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	1	2
H:H:?1	R:R:V20	3.99	1	Yes	Yes	0	6	1	2
H:H:?1	R:R:R21	5.42	1	Yes	No	0	4	1	1
H:H:?2	R:R:R21	8.67	1	No	No	0	4	0	1
H:H:?1	H:H:?2	37.44	1	Yes	No	0	0	1	0
H:H:?2	H:H:?3	25.61	1	No	No	0	0	0	1
H:H:?3	H:H:?6	44.29	0	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	23.91
Average Nodes In Shell	10.00
Average Hubs In Shell	3.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

5L7D

Protein

Frizzled

SMO

Homo sapiens

Cholesterol

3.2

2016-07-20

10.1038/nature18934

A 2D representation of the interactions of NAG in 5L7D
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K186	R:R:N188	9.79	12	No	No	4	8	1	1
H:H:?1	R:R:K186	10.06	12	No	No	0	4	0	1
H:H:?1	R:R:N188	35.52	12	No	No	0	8	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	22.79
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 5L7D
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D95	R:R:K105	13.83	1	Yes	Yes	5	4	2	2
R:R:D95	W:W:?2	8.17	1	Yes	Yes	5	0	2	1
R:R:K105	W:W:?2	5.66	1	Yes	Yes	4	0	2	1
R:R:L108	W:W:?2	5.56	0	No	Yes	5	0	2	1
R:R:W109	W:W:?2	44.59	0	Yes	Yes	7	0	2	1
R:R:L112	W:W:?2	12.51	0	No	Yes	8	0	2	1
R:R:I156	W:W:?2	7.16	0	No	Yes	5	0	2	1
R:R:E160	R:R:R485	4.65	1	No	Yes	4	5	1	2
R:R:E160	R:R:L489	10.6	1	No	No	4	4	1	2
H:H:?2	R:R:E160	14.18	1	Yes	No	0	4	0	1
R:R:R161	W:W:?2	21.95	1	No	Yes	5	0	1	1
H:H:?2	R:R:R161	6.5	1	Yes	No	0	5	0	1
R:R:L489	R:R:R485	4.86	1	No	Yes	4	5	2	2
R:R:L489	W:W:?2	5.56	1	No	Yes	4	0	2	1
R:R:A492	W:W:?2	7.91	0	No	Yes	5	0	2	1
H:H:?2	R:R:N493	28.17	1	Yes	No	0	5	0	1
R:R:I496	W:W:?2	4.3	0	No	Yes	4	0	2	1
H:H:?2	W:W:?2	7.44	1	Yes	Yes	0	0	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	14.07
Average Nodes In Shell	15.00
Average Hubs In Shell	6.00
Average Links In Shell	18.00
Average Links Mediated by Hubs In Shell	17.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

5NX2

Peptide

Glucagon

GLP-1

Homo sapiens

GLP-1 (Truncated)

3.7

2017-06-14

10.1038/nature22800

A 2D representation of the interactions of NAG in 5NX2
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F80	R:R:Y101	6.19	4	No	Yes	4	5	1	1
H:H:?1	R:R:F80	7.6	4	Yes	No	0	4	0	1
R:R:H99	R:R:N82	3.83	0	No	No	4	4	2	1
H:H:?1	R:R:N82	37.97	4	Yes	No	0	4	0	1
R:R:E125	R:R:G98	4.91	0	No	No	5	4	1	2
R:R:W120	R:R:Y101	6.75	0	No	Yes	5	5	2	1
R:R:D122	R:R:Y101	20.69	0	No	Yes	7	5	2	1
H:H:?1	R:R:Y101	7.32	4	Yes	Yes	0	5	0	1
H:H:?2	R:R:Y101	7.32	4	No	Yes	0	5	1	1
H:H:?1	H:H:?2	31.94	4	Yes	No	0	0	0	1
H:H:?1	R:R:E125	2.36	4	Yes	No	0	5	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	17.44
Average Nodes In Shell	10.00
Average Hubs In Shell	2.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 5NX2
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F80	R:R:Y101	6.19	4	No	Yes	4	5	2	1
H:H:?1	R:R:F80	7.6	4	Yes	No	0	4	1	2
H:H:?1	R:R:N82	37.97	4	Yes	No	0	4	1	2
R:R:W120	R:R:Y101	6.75	0	No	Yes	5	5	2	1
R:R:D122	R:R:Y101	20.69	0	No	Yes	7	5	2	1
H:H:?1	R:R:Y101	7.32	4	Yes	Yes	0	5	1	1
H:H:?2	R:R:Y101	7.32	4	No	Yes	0	5	0	1
H:H:?1	H:H:?2	31.94	4	Yes	No	0	0	1	0
H:H:?1	R:R:E125	2.36	4	Yes	No	0	5	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	19.63
Average Nodes In Shell	8.00
Average Hubs In Shell	2.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 5NX2
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:N63	22.05	0	No	No	0	4	0	1
R:R:F61	R:R:N63	2.42	6	Yes	No	3	4	2	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	22.05
Average Nodes In Shell	3.00
Average Hubs In Shell	1.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

5TE3

Sensory

Opsins

Rhodopsin

Bos taurus

Octyl Beta-D-Glucopyranoside

2.7

2017-03-15

10.1073/pnas.1617446114

A 2D representation of the interactions of NAG in 5TE3
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	8.77	2	No	No	7	6	1	1
R:R:T4	R:R:V20	11.11	2	No	Yes	6	6	1	2
H:H:?1	R:R:T4	5.26	2	Yes	No	0	6	0	1
R:R:N15	R:R:V20	10.35	2	No	Yes	7	6	1	2
H:H:?1	R:R:N15	24.5	2	Yes	No	0	7	0	1
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	0	1
H:H:?2	R:R:R21	7.59	0	No	No	0	4	1	2
H:H:?1	H:H:?2	38.55	2	Yes	No	0	0	0	1
H:H:?2	H:H:?3	25.61	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.60
Average Nodes In Shell	8.00
Average Hubs In Shell	2.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 5TE3
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	8.77	2	No	No	7	6	2	2
H:H:?1	R:R:T4	5.26	2	Yes	No	0	6	1	2
H:H:?1	R:R:N15	24.5	2	Yes	No	0	7	1	2
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	1	2
H:H:?2	R:R:R21	7.59	0	No	No	0	4	0	1
H:H:?1	H:H:?2	38.55	2	Yes	No	0	0	1	0
H:H:?2	H:H:?3	25.61	0	No	No	0	0	0	1
H:H:?3	H:H:?6	47.24	0	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	23.92
Average Nodes In Shell	9.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

5W0P

Sensory

Opsins

Rhodopsin

Homo sapiens

Arrestin1

3.01

2017-08-09

10.1016/j.cell.2017.07.002

A 2D representation of the interactions of NAG in 5W0P
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	5.85	1	Yes	No	7	9	1	2
R:R:T4	R:R:V20	7.93	1	No	Yes	9	5	2	1
R:R:V11	R:R:V20	4.81	1	Yes	Yes	5	5	2	1
R:R:V11	R:R:Y30	3.79	1	Yes	Yes	5	4	2	2
R:R:G18	R:R:N15	3.39	1	No	Yes	6	7	1	1
R:R:N15	R:R:V20	10.35	1	Yes	Yes	7	5	1	1
H:H:?1	R:R:N15	24.5	1	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	4.58	1	Yes	No	0	6	0	1
R:R:V20	R:R:Y30	8.83	1	Yes	Yes	5	4	1	2
H:H:?1	R:R:V20	5.32	1	Yes	Yes	0	5	0	1
R:R:R21	R:R:Y26	8.23	1	No	No	6	3	1	2
H:H:?1	R:R:R21	15.17	1	Yes	No	0	6	0	1
H:H:?2	R:R:R21	9.75	1	No	No	0	6	1	1
H:H:?1	H:H:?2	29.74	1	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	15.86
Average Nodes In Shell	10.00
Average Hubs In Shell	5.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 5W0P
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:G18	R:R:N15	3.39	1	No	Yes	6	7	2	2
R:R:N15	R:R:V20	10.35	1	Yes	Yes	7	5	2	2
H:H:?1	R:R:N15	24.5	1	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	4.58	1	Yes	No	0	6	1	2
H:H:?1	R:R:V20	5.32	1	Yes	Yes	0	5	1	2
R:R:R21	R:R:Y26	8.23	1	No	No	6	3	1	2
H:H:?1	R:R:R21	15.17	1	Yes	No	0	6	1	1
H:H:?2	R:R:R21	9.75	1	No	No	0	6	0	1
H:H:?1	H:H:?2	29.74	1	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	19.74
Average Nodes In Shell	7.00
Average Hubs In Shell	3.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

5WKT

Sensory

Opsins

Rhodopsin

Bos taurus

Octyl Beta-D-Glucopyranoside

Gt(CT)

3.2

2017-12-13

10.1038/nprot.2017.135

A 2D representation of the interactions of NAG in 5WKT
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	8.77	1	Yes	No	7	6	1	1
R:R:T4	R:R:V20	14.28	1	No	Yes	6	6	1	1
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	0	1
R:R:V11	R:R:V20	4.81	1	Yes	Yes	8	6	2	1
R:R:V11	R:R:Y30	5.05	1	Yes	Yes	8	4	2	2
R:R:G18	R:R:N15	3.39	1	No	Yes	3	7	1	1
R:R:N15	R:R:V20	10.35	1	Yes	Yes	7	6	1	1
H:H:?1	R:R:N15	24.5	1	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	7.63	1	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	11.36	1	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	5.32	1	Yes	Yes	0	6	0	1
H:H:?2	R:R:R21	6.5	0	No	No	0	4	1	2
H:H:?1	H:H:?2	34.14	1	Yes	No	0	0	0	1
H:H:?2	H:H:?3	61.47	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	15.37
Average Nodes In Shell	10.00
Average Hubs In Shell	5.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 5WKT
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	8.77	1	Yes	No	7	6	2	2
R:R:T4	R:R:V20	14.28	1	No	Yes	6	6	2	2
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	1	2
R:R:G18	R:R:N15	3.39	1	No	Yes	3	7	2	2
R:R:N15	R:R:V20	10.35	1	Yes	Yes	7	6	2	2
H:H:?1	R:R:N15	24.5	1	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	7.63	1	Yes	No	0	3	1	2
H:H:?1	R:R:V20	5.32	1	Yes	Yes	0	6	1	2
H:H:?2	R:R:R21	6.5	0	No	No	0	4	0	1
H:H:?1	H:H:?2	34.14	1	Yes	No	0	0	1	0
H:H:?2	H:H:?3	61.47	0	No	No	0	0	0	1
H:H:?3	H:H:?4	91.53	0	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	34.04
Average Nodes In Shell	10.00
Average Hubs In Shell	3.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

5XEZ

Peptide

Glucagon

Homo sapiens

NNC0640

2017-05-24

10.1038/nature22363

A 2D representation of the interactions of NAG in 5XEZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F62	R:R:Y39	4.13	2	Yes	Yes	7	6	2	1
R:R:S66	R:R:Y39	2.54	2	Yes	Yes	5	6	2	1
R:R:C67	R:R:Y39	4.03	2	Yes	Yes	9	6	1	1
R:R:P82	R:R:Y39	5.56	2	Yes	Yes	8	6	2	1
R:R:W83	R:R:Y39	16.4	2	Yes	Yes	2	6	2	1
R:R:Y39	R:R:Y84	8.94	2	Yes	Yes	6	5	1	2
H:H:?7	R:R:Y39	7.32	2	Yes	Yes	0	6	0	1
R:R:Q42	R:R:W83	6.57	2	No	Yes	5	2	1	2
H:H:?7	R:R:Q42	15.43	2	Yes	No	0	5	0	1
H:H:?8	R:R:Q42	5.94	2	No	No	0	5	1	1
R:R:C43	R:R:L47	3.17	2	Yes	No	9	5	2	2
R:R:C43	R:R:F62	8.38	2	Yes	Yes	9	7	2	2
R:R:C43	R:R:C67	7.28	2	Yes	Yes	9	9	2	1
H:H:?7	R:R:N46	31.85	2	Yes	No	0	5	0	1
R:R:C67	R:R:L47	4.76	2	Yes	No	9	5	1	2
R:R:P82	R:R:S66	5.34	2	Yes	Yes	8	5	2	2
H:H:?7	R:R:C67	2.83	2	Yes	Yes	0	9	0	1
R:R:P82	R:R:Y84	9.74	2	Yes	Yes	8	5	2	2
R:R:W83	R:R:Y84	1.93	2	Yes	Yes	2	5	2	2
H:H:?8	R:R:W83	2.03	2	No	Yes	0	2	1	2
H:H:?7	H:H:?8	36.34	2	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	18.75
Average Nodes In Shell	13.00
Average Hubs In Shell	9.00
Average Links In Shell	21.00
Average Links Mediated by Hubs In Shell	20.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 5XEZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L38	R:R:W83	2.28	0	No	Yes	3	2	2	1
R:R:C67	R:R:Y39	4.03	2	Yes	Yes	9	6	2	2
R:R:W83	R:R:Y39	16.4	2	Yes	Yes	2	6	1	2
R:R:Y39	R:R:Y84	8.94	2	Yes	Yes	6	5	2	2
H:H:?7	R:R:Y39	7.32	2	Yes	Yes	0	6	1	2
R:R:Q42	R:R:W83	6.57	2	No	Yes	5	2	1	1
H:H:?7	R:R:Q42	15.43	2	Yes	No	0	5	1	1
H:H:?8	R:R:Q42	5.94	2	No	No	0	5	0	1
H:H:?7	R:R:N46	31.85	2	Yes	No	0	5	1	2
H:H:?7	R:R:C67	2.83	2	Yes	Yes	0	9	1	2
R:R:W83	R:R:Y84	1.93	2	Yes	Yes	2	5	1	2
R:R:H88	R:R:W83	5.29	2	No	Yes	4	2	2	1
H:H:?8	R:R:W83	2.03	2	No	Yes	0	2	0	1
H:H:?7	H:H:?8	36.34	2	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	14.77
Average Nodes In Shell	10.00
Average Hubs In Shell	5.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	13.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 5XEZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F97	R:R:T76	3.89	6	Yes	No	5	5	1	2
R:R:F97	R:R:N78	4.83	6	Yes	No	5	4	1	1
H:H:?9	R:R:N78	25.72	6	No	No	0	4	0	1
R:R:F95	R:R:F97	2.14	0	No	Yes	1	5	2	1
R:R:D117	R:R:F97	2.39	0	No	Yes	7	5	2	1
R:R:F97	R:R:Q120	3.51	6	Yes	No	5	5	1	2
H:H:?9	R:R:F97	6.52	6	No	Yes	0	5	0	1
H:H:?10	H:H:?9	42.95	0	No	No	0	0	1	0

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	25.06
Average Nodes In Shell	8.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 5XEZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F97	R:R:N78	4.83	6	Yes	No	5	4	2	2
H:H:?9	R:R:N78	25.72	6	No	No	0	4	1	2
H:H:?9	R:R:F97	6.52	6	No	Yes	0	5	1	2
H:H:?10	H:H:?9	42.95	0	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	42.95
Average Nodes In Shell	4.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	2.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 5XEZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:P52	R:R:P53	1.95	0	No	Yes	1	3	2	1
R:R:P53	R:R:V57	3.53	2	Yes	No	3	3	1	2
R:R:P53	R:R:R60	2.88	2	Yes	Yes	3	4	1	2
R:R:D70	R:R:P53	8.05	2	No	Yes	4	3	2	1
H:H:?12	R:R:P53	2.93	0	No	Yes	0	3	0	1
R:R:D70	R:R:V57	5.84	2	No	No	4	3	2	2
H:H:?12	R:R:N59	25.72	0	No	No	0	4	0	1
R:R:D70	R:R:R60	17.87	2	No	Yes	4	4	2	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	14.32
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 5XEZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N74	R:R:P102	4.89	0	No	No	7	1	1	2
H:H:?13	R:R:N74	22.05	0	No	No	0	7	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	22.05
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

5XF1

Peptide

Glucagon

Homo sapiens

NNC0640

3.19

2017-05-24

10.1038/nature22363

A 2D representation of the interactions of NAG in 5XF1
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L38	R:R:W83	2.28	0	No	Yes	3	2	2	1
R:R:F62	R:R:Y39	4.13	2	Yes	Yes	7	6	2	1
R:R:S66	R:R:Y39	2.54	2	Yes	Yes	5	6	2	1
R:R:P82	R:R:Y39	5.56	2	Yes	Yes	8	6	2	1
R:R:W83	R:R:Y39	13.5	2	Yes	Yes	2	6	1	1
R:R:Y39	R:R:Y84	9.93	2	Yes	Yes	6	5	1	2
H:H:?7	R:R:Y39	5.23	2	Yes	Yes	0	6	0	1
R:R:Q42	R:R:W83	5.48	2	No	Yes	5	2	1	1
H:H:?7	R:R:Q42	15.43	2	Yes	No	0	5	0	1
R:R:C43	R:R:L47	3.17	2	Yes	No	9	5	2	2
R:R:C43	R:R:F62	5.59	2	Yes	Yes	9	7	2	2
R:R:C43	R:R:C67	7.28	2	Yes	No	9	9	2	1
H:H:?7	R:R:N46	24.5	2	Yes	No	0	5	0	1
R:R:C67	R:R:L47	4.76	2	No	No	9	5	1	2
R:R:P82	R:R:S66	5.34	2	Yes	Yes	8	5	2	2
H:H:?7	R:R:C67	2.83	2	Yes	No	0	9	0	1
R:R:P82	R:R:Y84	9.74	2	Yes	Yes	8	5	2	2
R:R:W83	R:R:Y84	1.93	2	Yes	Yes	2	5	1	2
R:R:H88	R:R:W83	2.12	2	No	Yes	4	2	2	1
H:H:?7	R:R:W83	2.03	2	Yes	Yes	0	2	0	1
H:H:?8	R:R:W83	3.05	2	No	Yes	0	2	1	1
H:H:?7	H:H:?8	39.65	2	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	14.94
Average Nodes In Shell	15.00
Average Hubs In Shell	8.00
Average Links In Shell	22.00
Average Links Mediated by Hubs In Shell	21.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 5XF1
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L38	R:R:W83	2.28	0	No	Yes	3	2	2	1
R:R:W83	R:R:Y39	13.5	2	Yes	Yes	2	6	1	2
R:R:Y39	R:R:Y84	9.93	2	Yes	Yes	6	5	2	2
H:H:?7	R:R:Y39	5.23	2	Yes	Yes	0	6	1	2
R:R:Q42	R:R:W83	5.48	2	No	Yes	5	2	2	1
H:H:?7	R:R:Q42	15.43	2	Yes	No	0	5	1	2
H:H:?7	R:R:N46	24.5	2	Yes	No	0	5	1	2
H:H:?7	R:R:C67	2.83	2	Yes	No	0	9	1	2
R:R:W83	R:R:Y84	1.93	2	Yes	Yes	2	5	1	2
R:R:H88	R:R:W83	2.12	2	No	Yes	4	2	2	1
H:H:?7	R:R:W83	2.03	2	Yes	Yes	0	2	1	1
H:H:?8	R:R:W83	3.05	2	No	Yes	0	2	0	1
H:H:?7	H:H:?8	39.65	2	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	21.35
Average Nodes In Shell	10.00
Average Hubs In Shell	4.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	13.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 5XF1
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:P52	R:R:P53	1.95	0	No	Yes	1	3	2	1
R:R:P53	R:R:V57	1.77	7	Yes	Yes	3	3	1	2
R:R:D70	R:R:P53	3.22	7	No	Yes	4	3	2	1
H:H:?9	R:R:P53	2.93	0	Yes	Yes	0	3	0	1
R:R:D70	R:R:V57	4.38	7	No	Yes	4	3	2	2
H:H:?9	R:R:N59	31.85	0	Yes	No	0	4	0	1
H:H:?9	R:R:Q105	7.12	0	Yes	No	0	5	0	1
H:H:?10	H:H:?9	30.84	0	No	Yes	0	0	1	0
H:H:?10	H:H:?11	26.43	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	18.18
Average Nodes In Shell	9.00
Average Hubs In Shell	3.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 5XF1
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?9	R:R:P53	2.93	Yes	Yes	3	1	2
H:H:?9	R:R:N59	31.85	Yes	No	4	1	2
H:H:?9	R:R:Q105	7.12	Yes	No	5	1	2
H:H:?10	H:H:?9	30.84	No	Yes	0	0	1
H:H:?10	H:H:?11	26.43	No	No	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	28.63
Average Nodes In Shell	6.00
Average Hubs In Shell	2.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 5XF1
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?10	H:H:?9	30.84	0	No	Yes	0	0	1	2
H:H:?10	H:H:?11	26.43	0	No	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	26.43
Average Nodes In Shell	3.00
Average Hubs In Shell	1.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 5XF1
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F97	R:R:T76	2.59	8	Yes	No	5	5	1	2
R:R:F97	R:R:N78	8.46	8	Yes	No	5	4	1	1
H:H:?12	R:R:N78	24.5	8	No	No	0	4	0	1
R:R:D117	R:R:F97	4.78	0	No	Yes	7	5	2	1
R:R:F97	R:R:Q120	3.51	8	Yes	No	5	5	1	2
H:H:?12	R:R:F97	5.43	8	No	Yes	0	5	0	1
H:H:?12	H:H:?13	35.24	8	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	21.72
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 5XF1
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F97	R:R:N78	8.46	8	Yes	No	5	4	2	2
H:H:?12	R:R:N78	24.5	8	No	No	0	4	1	2
H:H:?12	R:R:F97	5.43	8	No	Yes	0	5	1	2
H:H:?12	H:H:?13	35.24	8	No	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	35.24
Average Nodes In Shell	4.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	2.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 5XF1
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?14	R:R:A73	4.22	No	No	0	6	0	1
R:R:N74	R:R:R99	2.41	No	No	7	3	1	2
R:R:N74	R:R:P102	9.77	No	No	7	1	1	2
H:H:?14	R:R:N74	23.27	No	No	0	7	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.74
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

5YQZ

Peptide

Glucagon

Homo sapiens

Glucagon analogue

2018-01-17

10.1038/nature25153

A 2D representation of the interactions of NAG in 5YQZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D70	R:R:N59	4.04	No	No	4	4	2	1
H:H:?1	R:R:N59	31.85	No	No	0	4	0	1
H:H:?1	H:H:?2	27.53	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	29.69
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 5YQZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:N59	31.85	0	No	No	0	4	1	2
H:H:?1	H:H:?2	27.53	0	No	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	27.53
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 5YQZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F97	R:R:N78	7.25	Yes	No	5	4	2	1
H:H:?3	R:R:N78	33.07	No	No	0	4	0	1
R:R:F95	R:R:S80	6.61	No	No	1	3	1	2
H:H:?3	R:R:F95	18.47	No	No	0	1	0	1
H:H:?3	H:H:?4	27.53	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	26.36
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 5YQZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:N78	33.07	No	No	4	1	2
H:H:?3	R:R:F95	18.47	No	No	1	1	2
H:H:?3	H:H:?4	27.53	No	No	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	27.53
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6CMO

Sensory

Opsins

Rhodopsin

Homo sapiens

Gi1/Beta1/Gamma2

4.5

2018-06-20

10.1038/s41586-018-0215-y

A 2D representation of the interactions of NAG in 6CMO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	2.92	17	Yes	No	7	9	1	1
H:H:?1	R:R:T4	13.15	17	Yes	No	0	9	0	1
R:R:G18	R:R:N15	3.39	17	No	Yes	6	7	1	1
R:R:N15	R:R:V20	11.82	17	Yes	No	7	5	1	1
H:H:?1	R:R:N15	28.17	17	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	7.63	17	Yes	No	0	6	0	1
R:R:V20	R:R:Y30	2.52	17	No	No	5	4	1	2
H:H:?1	R:R:V20	6.64	17	Yes	No	0	5	0	1
H:H:?1	R:R:R21	13	17	Yes	No	0	6	0	1
H:H:?1	H:H:?2	38.55	17	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	17.86
Average Nodes In Shell	8.00
Average Hubs In Shell	2.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6CMO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	2.92	17	Yes	No	7	9	2	2
H:H:?1	R:R:T4	13.15	17	Yes	No	0	9	1	2
R:R:G18	R:R:N15	3.39	17	No	Yes	6	7	2	2
R:R:N15	R:R:V20	11.82	17	Yes	No	7	5	2	2
H:H:?1	R:R:N15	28.17	17	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	7.63	17	Yes	No	0	6	1	2
H:H:?1	R:R:V20	6.64	17	Yes	No	0	5	1	2
H:H:?1	R:R:R21	13	17	Yes	No	0	6	1	2
H:H:?1	H:H:?2	38.55	17	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	38.55
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6DO1

Peptide

Angiotensin

AT1

Homo sapiens

Angiotensin-Like peptide S1I8

2.9

2019-01-30

10.1016/j.cell.2018.12.006

A 2D representation of the interactions of NAG in 6DO1
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F171	R:R:N176	4.83	6	Yes	No	6	5	2	1
H:H:?2	R:R:N176	24.5	0	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	24.50
Average Nodes In Shell	3.00
Average Hubs In Shell	1.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6FJ3

Peptide

Parathyroid hormone

PTH1

Homo sapiens

PTH

2.5

2018-11-21

10.1038/s41594-018-0151-4

A 2D representation of the interactions of NAG in 6FJ3
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?2	R:R:N161	29.4	2	No	No	0	7	0	1
H:H:?5	R:R:N161	7.37	2	Yes	No	0	7	1	1
L:L:Y34	R:R:T163	4.99	2	Yes	Yes	0	5	2	2
H:H:?5	R:R:T163	9.49	2	Yes	Yes	0	5	1	2
H:H:?5	L:L:Y34	17.61	2	Yes	Yes	0	0	1	2
H:H:?2	H:H:?3	42.95	2	No	No	0	0	0	1
H:H:?2	H:H:?5	27.82	2	No	Yes	0	0	0	1
H:H:?3	H:H:?4	33.3	2	No	No	0	0	1	2
H:H:?3	H:H:?5	5.3	2	No	Yes	0	0	1	1
R:R:L156	R:R:N161	2.75	0	No	No	4	7	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	33.39
Average Nodes In Shell	8.00
Average Hubs In Shell	3.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6FJ3
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?2	R:R:N161	29.4	2	No	No	7	1	2
H:H:?5	R:R:N161	7.37	2	Yes	No	7	1	2
L:L:Y34	R:R:T163	4.99	2	Yes	Yes	5	2	2
H:H:?5	R:R:T163	9.49	2	Yes	Yes	5	1	2
H:H:?5	L:L:Y34	17.61	2	Yes	Yes	0	1	2
H:H:?2	H:H:?3	42.95	2	No	No	0	1	0
H:H:?2	H:H:?5	27.82	2	No	Yes	0	1	1
H:H:?3	H:H:?4	33.3	2	No	No	0	0	1
H:H:?3	H:H:?5	5.3	2	No	Yes	0	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	27.18
Average Nodes In Shell	7.00
Average Hubs In Shell	3.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6FJ3
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E169	R:R:G142	4.91	3	Yes	No	5	5	1	2
R:R:H143	R:R:Y145	4.36	0	No	Yes	3	4	2	1
R:R:N166	R:R:Y145	4.65	3	Yes	Yes	7	4	1	1
R:R:E169	R:R:Y145	8.98	3	Yes	Yes	5	4	1	1
H:H:?6	R:R:Y145	10.46	3	Yes	Yes	0	4	0	1
H:H:?9	R:R:Y145	22.64	3	Yes	Yes	0	4	1	1
R:R:N166	R:R:W164	5.65	3	Yes	No	7	5	1	2
R:R:N166	R:R:S168	5.96	3	Yes	No	7	6	1	1
H:H:?6	R:R:N166	28.17	3	Yes	Yes	0	7	0	1
H:H:?6	R:R:S168	9.38	3	Yes	No	0	6	0	1
H:H:?6	R:R:E169	4.73	3	Yes	Yes	0	5	0	1
H:H:?9	R:R:E169	5.69	3	Yes	Yes	0	5	1	1
H:H:?6	H:H:?7	29.74	3	Yes	No	0	0	0	1
H:H:?6	H:H:?9	22.52	3	Yes	Yes	0	0	0	1
H:H:?7	H:H:?8	30.74	3	No	No	0	0	1	2
H:H:?7	H:H:?9	9.27	3	No	Yes	0	0	1	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	17.50
Average Nodes In Shell	11.00
Average Hubs In Shell	5.00
Average Links In Shell	16.00
Average Links Mediated by Hubs In Shell	15.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6FJ3
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N166	R:R:Y145	4.65	3	Yes	Yes	7	4	2	2
R:R:E169	R:R:Y145	8.98	3	Yes	Yes	5	4	2	2
H:H:?6	R:R:Y145	10.46	3	Yes	Yes	0	4	1	2
H:H:?9	R:R:Y145	22.64	3	Yes	Yes	0	4	1	2
R:R:N166	R:R:S168	5.96	3	Yes	No	7	6	2	2
H:H:?6	R:R:N166	28.17	3	Yes	Yes	0	7	1	2
H:H:?6	R:R:S168	9.38	3	Yes	No	0	6	1	2
H:H:?6	R:R:E169	4.73	3	Yes	Yes	0	5	1	2
H:H:?9	R:R:E169	5.69	3	Yes	Yes	0	5	1	2
H:H:?6	H:H:?7	29.74	3	Yes	No	0	0	1	0
H:H:?6	H:H:?9	22.52	3	Yes	Yes	0	0	1	1
H:H:?7	H:H:?8	30.74	3	No	No	0	0	0	1
H:H:?7	H:H:?9	9.27	3	No	Yes	0	0	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	23.25
Average Nodes In Shell	8.00
Average Hubs In Shell	5.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6FJ3
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D149	R:R:S153	4.42	0	No	No	5	4	1	2
H:H:?10	R:R:D149	6.05	0	Yes	No	0	5	0	1
H:H:?10	R:R:R150	9.75	0	Yes	No	0	1	0	1
H:H:?10	R:R:N151	24.5	0	Yes	No	0	5	0	1
H:H:?10	H:H:?11	41.85	0	Yes	No	0	0	0	1
H:H:?11	H:H:?12	34.58	0	No	No	0	0	1	2
R:R:G152	R:R:N151	1.7	2	No	No	9	5	2	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	20.54
Average Nodes In Shell	8.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6FJ3
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?10	R:R:D149	6.05	Yes	No	5	1	2
H:H:?10	R:R:R150	9.75	Yes	No	1	1	2
H:H:?10	R:R:N151	24.5	Yes	No	5	1	2
H:H:?10	H:H:?11	41.85	Yes	No	0	1	0
H:H:?11	H:H:?12	34.58	No	No	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	38.22
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6FK6

Sensory

Opsins

Rhodopsin

Bos taurus

PubChem 132473033

2.36

2018-04-04

10.1073/pnas.1718084115

A 2D representation of the interactions of NAG in 6FK6
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	7.31	2	No	No	7	6	1	1
R:R:T4	R:R:V20	12.69	2	No	Yes	6	6	1	1
H:H:?1	R:R:T4	5.26	2	Yes	No	0	6	0	1
R:R:V11	R:R:V20	4.81	2	No	Yes	8	6	2	1
R:R:V11	R:R:Y30	3.79	2	No	Yes	8	4	2	2
R:R:F13	R:R:V20	5.24	2	No	Yes	4	6	2	1
R:R:F13	R:R:Y30	13.41	2	No	Yes	4	4	2	2
R:R:N15	R:R:V20	10.35	2	No	Yes	7	6	1	1
H:H:?1	R:R:N15	25.72	2	Yes	No	0	7	0	1
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	11.36	2	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	3.99	2	Yes	Yes	0	6	0	1
H:H:?2	R:R:R21	6.5	0	No	No	0	4	1	2
H:H:?1	H:H:?2	36.34	2	Yes	No	0	0	0	1
H:H:?2	H:H:?3	34.58	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	15.48
Average Nodes In Shell	11.00
Average Hubs In Shell	3.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6FK6
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	7.31	2	No	No	7	6	2	2
R:R:T4	R:R:V20	12.69	2	No	Yes	6	6	2	2
H:H:?1	R:R:T4	5.26	2	Yes	No	0	6	1	2
R:R:N15	R:R:V20	10.35	2	No	Yes	7	6	2	2
H:H:?1	R:R:N15	25.72	2	Yes	No	0	7	1	2
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	1	2
H:H:?1	R:R:V20	3.99	2	Yes	Yes	0	6	1	2
H:H:?2	R:R:R21	6.5	0	No	No	0	4	0	1
H:H:?1	H:H:?2	36.34	2	Yes	No	0	0	1	0
H:H:?2	H:H:?3	34.58	0	No	No	0	0	0	1
H:H:?3	H:H:?5	50.19	0	No	No	0	0	1	2
H:H:?3	H:H:?6	35.43	0	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	25.81
Average Nodes In Shell	11.00
Average Hubs In Shell	2.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6FK7

Sensory

Opsins

Rhodopsin

Bos taurus

PubChem 132473034

2.62

2018-04-04

10.1073/pnas.1718084115

A 2D representation of the interactions of NAG in 6FK7
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	10.24	2	No	No	7	6	1	1
R:R:T4	R:R:V20	12.69	2	No	Yes	6	6	1	2
H:H:?1	R:R:T4	5.26	2	Yes	No	0	6	0	1
R:R:N15	R:R:V20	10.35	2	No	Yes	7	6	1	2
H:H:?1	R:R:N15	25.72	2	Yes	No	0	7	0	1
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	0	1
H:H:?2	R:R:R21	8.67	0	No	No	0	4	1	2
H:H:?1	H:H:?2	36.34	2	Yes	No	0	0	0	1
H:H:?2	H:H:?3	30.74	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.36
Average Nodes In Shell	8.00
Average Hubs In Shell	2.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6FK7
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	10.24	2	No	No	7	6	2	2
H:H:?1	R:R:T4	5.26	2	Yes	No	0	6	1	2
H:H:?1	R:R:N15	25.72	2	Yes	No	0	7	1	2
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	1	2
H:H:?2	R:R:R21	8.67	0	No	No	0	4	0	1
H:H:?1	H:H:?2	36.34	2	Yes	No	0	0	1	0
H:H:?2	H:H:?3	30.74	0	No	No	0	0	0	1
H:H:?3	H:H:?4	41.33	0	No	No	0	0	1	2
H:H:?3	H:H:?5	28.05	0	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	25.25
Average Nodes In Shell	10.00
Average Hubs In Shell	1.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6FK8

Sensory

Opsins

Rhodopsin

Bos taurus

PubChem 132473035

2.87

2018-04-04

10.1073/pnas.1718084115

A 2D representation of the interactions of NAG in 6FK8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	8.77	1	No	No	7	6	1	1
R:R:T4	R:R:V20	11.11	1	No	Yes	6	6	1	1
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	0	1
R:R:V11	R:R:V20	4.81	1	No	Yes	8	6	2	1
R:R:N15	R:R:V20	10.35	1	No	Yes	7	6	1	1
H:H:?1	R:R:N15	25.72	1	Yes	No	0	7	0	1
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	11.36	1	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	7.97	1	Yes	Yes	0	6	0	1
H:H:?1	R:R:R21	4.33	1	Yes	No	0	4	0	1
H:H:?2	R:R:R21	8.67	1	No	No	0	4	1	1
H:H:?1	H:H:?2	35.24	1	Yes	No	0	0	0	1
H:H:?2	H:H:?3	34.58	1	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	14.10
Average Nodes In Shell	11.00
Average Hubs In Shell	3.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6FK8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	8.77	1	No	No	7	6	2	2
R:R:T4	R:R:V20	11.11	1	No	Yes	6	6	2	2
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	1	2
R:R:N15	R:R:V20	10.35	1	No	Yes	7	6	2	2
H:H:?1	R:R:N15	25.72	1	Yes	No	0	7	1	2
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	1	2
H:H:?1	R:R:V20	7.97	1	Yes	Yes	0	6	1	2
H:H:?1	R:R:R21	4.33	1	Yes	No	0	4	1	1
H:H:?2	R:R:R21	8.67	1	No	No	0	4	0	1
H:H:?1	H:H:?2	35.24	1	Yes	No	0	0	1	0
H:H:?2	H:H:?3	34.58	1	No	No	0	0	0	1
H:H:?3	H:H:?5	45.76	0	No	No	0	0	1	2
H:H:?3	H:H:?6	26.57	0	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	26.16
Average Nodes In Shell	11.00
Average Hubs In Shell	2.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6FK9

Sensory

Opsins

Rhodopsin

Bos taurus

PubChem 132473036

2.63

2018-04-04

10.1073/pnas.1718084115

A 2D representation of the interactions of NAG in 6FK9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	10.24	1	No	No	7	6	1	1
R:R:T4	R:R:V20	12.69	1	No	Yes	6	6	1	2
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	0	1
R:R:N15	R:R:V20	10.35	1	No	Yes	7	6	1	2
H:H:?1	R:R:N15	24.5	1	Yes	No	0	7	0	1
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	0	1
H:H:?2	R:R:R21	7.59	0	No	No	0	4	1	2
H:H:?1	H:H:?2	38.55	1	Yes	No	0	0	0	1
H:H:?2	H:H:?3	30.74	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.60
Average Nodes In Shell	8.00
Average Hubs In Shell	2.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6FK9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	10.24	1	No	No	7	6	2	2
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	1	2
H:H:?1	R:R:N15	24.5	1	Yes	No	0	7	1	2
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	1	2
R:R:A26	R:R:R21	4.15	0	No	No	2	4	2	1
H:H:?2	R:R:R21	7.59	0	No	No	0	4	0	1
H:H:?1	H:H:?2	38.55	1	Yes	No	0	0	1	0
H:H:?2	H:H:?3	30.74	0	No	No	0	0	0	1
H:H:?3	H:H:?4	44.29	0	No	No	0	0	1	2
H:H:?3	H:H:?5	29.52	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	25.63
Average Nodes In Shell	10.00
Average Hubs In Shell	1.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6FKA

Sensory

Opsins

Rhodopsin

Bos taurus

PubChem 132473037

2.7

2018-04-04

10.1073/pnas.1718084115

A 2D representation of the interactions of NAG in 6FKA
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	8.77	1	Yes	No	7	6	1	1
R:R:T4	R:R:V20	12.69	1	No	Yes	6	6	1	1
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	0	1
R:R:V11	R:R:V20	4.81	1	No	Yes	8	6	2	1
R:R:V11	R:R:Y30	5.05	1	No	Yes	8	4	2	2
R:R:F13	R:R:V20	5.24	1	No	Yes	4	6	2	1
R:R:F13	R:R:Y30	14.44	1	No	Yes	4	4	2	2
R:R:G18	R:R:N15	5.09	1	No	Yes	3	7	1	1
R:R:N15	R:R:V20	10.35	1	Yes	Yes	7	6	1	1
H:H:?1	R:R:N15	25.72	1	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	11.36	1	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	3.99	1	Yes	Yes	0	6	0	1
H:H:?2	R:R:R21	7.59	0	No	No	0	4	1	2
H:H:?1	H:H:?2	36.34	1	Yes	No	0	0	0	1
H:H:?2	H:H:?3	30.74	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	15.48
Average Nodes In Shell	11.00
Average Hubs In Shell	4.00
Average Links In Shell	16.00
Average Links Mediated by Hubs In Shell	14.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6FKA
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	8.77	1	Yes	No	7	6	2	2
R:R:T4	R:R:V20	12.69	1	No	Yes	6	6	2	2
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	1	2
R:R:G18	R:R:N15	5.09	1	No	Yes	3	7	2	2
R:R:N15	R:R:V20	10.35	1	Yes	Yes	7	6	2	2
H:H:?1	R:R:N15	25.72	1	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	1	2
H:H:?1	R:R:V20	3.99	1	Yes	Yes	0	6	1	2
H:H:?2	R:R:R21	7.59	0	No	No	0	4	0	1
H:H:?1	H:H:?2	36.34	1	Yes	No	0	0	1	0
H:H:?2	H:H:?3	30.74	0	No	No	0	0	0	1
H:H:?3	H:H:?4	42.81	0	No	No	0	0	1	2
H:H:?3	H:H:?5	29.52	0	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	24.89
Average Nodes In Shell	11.00
Average Hubs In Shell	3.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6FKB

Sensory

Opsins

Rhodopsin

Bos taurus

PubChem 132473038

3.03

2018-04-04

10.1073/pnas.1718084115

A 2D representation of the interactions of NAG in 6FKB
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	11.7	1	No	No	7	6	1	1
R:R:T4	R:R:V20	12.69	1	No	Yes	6	6	1	1
H:H:?2	R:R:T4	5.26	1	Yes	No	0	6	0	1
R:R:V11	R:R:V20	4.81	1	Yes	Yes	8	6	2	1
R:R:V11	R:R:Y30	3.79	1	Yes	Yes	8	4	2	2
R:R:N15	R:R:V20	7.39	1	No	Yes	7	6	1	1
H:H:?2	R:R:N15	13.47	1	Yes	No	0	7	0	1
H:H:?2	R:R:G18	6.1	1	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	11.36	1	Yes	Yes	6	4	1	2
H:H:?2	R:R:V20	6.64	1	Yes	Yes	0	6	0	1
H:H:?2	R:R:R21	8.67	1	Yes	No	0	4	0	1
H:H:?2	H:H:?3	33.04	1	Yes	No	0	0	0	1
H:H:?3	H:H:?4	17.93	0	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	12.20
Average Nodes In Shell	11.00
Average Hubs In Shell	4.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6FKB
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	11.7	1	No	No	7	6	2	2
R:R:T4	R:R:V20	12.69	1	No	Yes	6	6	2	2
H:H:?2	R:R:T4	5.26	1	Yes	No	0	6	1	2
R:R:N15	R:R:V20	7.39	1	No	Yes	7	6	2	2
H:H:?2	R:R:N15	13.47	1	Yes	No	0	7	1	2
H:H:?2	R:R:G18	6.1	1	Yes	No	0	3	1	2
H:H:?2	R:R:V20	6.64	1	Yes	Yes	0	6	1	2
H:H:?2	R:R:R21	8.67	1	Yes	No	0	4	1	2
H:H:?2	H:H:?3	33.04	1	Yes	No	0	0	1	0
H:H:?3	H:H:?4	17.93	0	No	No	0	0	0	1
H:H:?4	H:H:?5	38.38	0	No	No	0	0	1	2
H:H:?4	H:H:?6	36.91	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	25.48
Average Nodes In Shell	10.00
Average Hubs In Shell	2.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6FKC

Sensory

Opsins

Rhodopsin

Bos taurus

PubChem 132473039

2.46

2018-04-04

10.1073/pnas.1718084115

A 2D representation of the interactions of NAG in 6FKC
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	8.77	1	No	No	7	6	1	1
R:R:T4	R:R:V20	12.69	1	No	Yes	6	6	1	1
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	0	1
R:R:V11	R:R:V20	4.81	1	Yes	Yes	8	6	2	1
R:R:V11	R:R:Y30	3.79	1	Yes	Yes	8	4	2	2
R:R:F13	R:R:V20	5.24	1	No	Yes	4	6	2	1
R:R:F13	R:R:Y30	13.41	1	No	Yes	4	4	2	2
R:R:N15	R:R:V20	10.35	1	No	Yes	7	6	1	1
H:H:?1	R:R:N15	25.72	1	Yes	No	0	7	0	1
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	10.09	1	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	3.99	1	Yes	Yes	0	6	0	1
H:H:?2	R:R:R21	6.5	0	No	No	0	4	1	2
H:H:?1	H:H:?2	36.34	1	Yes	No	0	0	0	1
H:H:?2	H:H:?3	30.74	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	15.48
Average Nodes In Shell	11.00
Average Hubs In Shell	4.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6FKC
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	8.77	1	No	No	7	6	2	2
R:R:T4	R:R:V20	12.69	1	No	Yes	6	6	2	2
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	1	2
R:R:N15	R:R:V20	10.35	1	No	Yes	7	6	2	2
H:H:?1	R:R:N15	25.72	1	Yes	No	0	7	1	2
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	1	2
H:H:?1	R:R:V20	3.99	1	Yes	Yes	0	6	1	2
H:H:?2	R:R:R21	6.5	0	No	No	0	4	0	1
H:H:?1	H:H:?2	36.34	1	Yes	No	0	0	1	0
H:H:?2	H:H:?3	30.74	0	No	No	0	0	0	1
H:H:?3	H:H:?4	38.38	0	No	No	0	0	1	2
H:H:?3	H:H:?5	28.05	0	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	24.53
Average Nodes In Shell	11.00
Average Hubs In Shell	2.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6FKD

Sensory

Opsins

Rhodopsin

Bos taurus

PubChem 137349183

2.49

2018-04-04

10.1073/pnas.1718084115

A 2D representation of the interactions of NAG in 6FKD
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	8.77	2	Yes	No	7	6	1	1
R:R:T4	R:R:V20	12.69	2	No	Yes	6	6	1	2
H:H:?1	R:R:T4	5.26	2	Yes	No	0	6	0	1
R:R:G18	R:R:N15	5.09	2	No	Yes	3	7	1	1
R:R:N15	R:R:V20	10.35	2	Yes	Yes	7	6	1	2
H:H:?1	R:R:N15	25.72	2	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	0	1
H:H:?1	R:R:R21	3.25	2	Yes	No	0	4	0	1
H:H:?2	R:R:R21	6.5	2	No	No	0	4	1	1
H:H:?1	H:H:?2	40.75	2	Yes	No	0	0	0	1
H:H:?2	H:H:?3	30.74	2	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	16.22
Average Nodes In Shell	9.00
Average Hubs In Shell	3.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6FKD
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	8.77	2	Yes	No	7	6	2	2
H:H:?1	R:R:T4	5.26	2	Yes	No	0	6	1	2
R:R:G18	R:R:N15	5.09	2	No	Yes	3	7	2	2
H:H:?1	R:R:N15	25.72	2	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	1	2
H:H:?1	R:R:R21	3.25	2	Yes	No	0	4	1	1
H:H:?2	R:R:R21	6.5	2	No	No	0	4	0	1
H:H:?1	H:H:?2	40.75	2	Yes	No	0	0	1	0
H:H:?2	H:H:?3	30.74	2	No	No	0	0	0	1
H:H:?3	H:H:?4	44.29	0	No	No	0	0	1	2
H:H:?3	H:H:?5	32.48	0	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	26.00
Average Nodes In Shell	10.00
Average Hubs In Shell	2.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6FUF

Sensory

Opsins

Rhodopsin

Bos taurus

All-trans-retinal

Go/Beta1/Gamma2

3.12

2018-10-03

10.1126/sciadv.aat7052

A 2D representation of the interactions of NAG in 6FUF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:T4	R:R:V20	11.11	No	No	6	6	1	2
H:H:?1	R:R:T4	3.94	No	No	0	6	0	1
R:R:G18	R:R:N15	3.39	No	No	3	7	2	1
R:R:N15	R:R:V20	8.87	No	No	7	6	1	2
H:H:?1	R:R:N15	24.5	No	No	0	7	0	1
R:R:E25	R:R:R21	8.14	No	No	7	4	2	1
H:H:?1	R:R:R21	11.92	No	No	0	4	0	1
R:R:A26	R:R:R21	2.77	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.45
Average Nodes In Shell	8.00
Average Hubs In Shell	0.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6LN2

Peptide

Glucagon

GLP-1

Homo sapiens

PubChem 68178630

3.2

2020-03-18

10.1038/s41467-020-14934-5

A 2D representation of the interactions of NAG in 6LN2
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F103	R:R:F80	10.72	3	Yes	No	4	4	2	1
R:R:F80	R:R:W120	5.01	0	No	Yes	4	5	1	2
H:H:?1	R:R:F80	11.95	3	No	No	0	4	0	1
R:R:N82	R:R:Y101	17.44	3	No	Yes	4	5	1	1
H:H:?1	R:R:N82	25.72	3	No	No	0	4	0	1
R:R:H99	R:R:Y101	10.89	3	Yes	Yes	4	5	2	1
R:R:E125	R:R:H99	4.92	3	Yes	Yes	5	4	2	2
R:R:D122	R:R:Y101	5.75	3	Yes	Yes	7	5	2	1
R:R:E125	R:R:Y101	5.61	3	Yes	Yes	5	5	2	1
H:H:?1	R:R:Y101	6.27	3	No	Yes	0	5	0	1
R:R:D122	R:R:W120	5.58	3	Yes	Yes	7	5	2	2
R:R:D122	R:R:E125	6.5	3	Yes	Yes	7	5	2	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	14.65
Average Nodes In Shell	9.00
Average Hubs In Shell	6.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6MEO

Protein

Chemokine

CCR5

Homo sapiens

Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4

3.9

2018-12-12

10.1038/s41586-018-0804-9

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:N91	L:L:T234	8.77	No	No	8	5	2	1
L:L:T234	L:L:W93	3.64	No	Yes	5	9	1	2
L:L:G235	L:L:N232	3.39	No	No	9	6	2	1
H:H:?3	L:L:N232	25.72	No	No	0	6	0	1
H:H:?3	H:H:?4	35.24	No	No	0	0	0	1
H:H:?3	L:L:T234	1.31	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	20.76
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?3	L:L:N232	25.72	No	No	6	1	2
H:H:?3	H:H:?4	35.24	No	No	0	1	0
H:H:?3	L:L:T234	1.31	No	No	5	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	35.24
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:E80	L:L:N227	3.94	1	No	Yes	9	5	2	1
L:L:E80	L:L:S241	8.62	1	No	No	9	9	2	2
L:L:S241	L:L:V82	3.23	1	No	No	9	1	2	1
H:H:?5	L:L:V82	3.99	1	Yes	No	0	1	0	1
L:L:K225	L:L:N227	2.8	1	No	Yes	8	5	2	1
L:L:N227	L:L:N239	12.26	1	Yes	No	5	9	1	1
L:L:N227	L:L:S241	5.96	1	Yes	No	5	9	1	2
H:H:?5	L:L:N227	11.02	1	Yes	Yes	0	5	0	1
H:H:?5	L:L:N239	26.95	1	Yes	No	0	9	0	1
H:H:?5	H:H:?6	36.34	1	Yes	No	0	0	0	1
H:H:?6	H:H:?7	28.17	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	19.58
Average Nodes In Shell	9.00
Average Hubs In Shell	2.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?5	L:L:V82	3.99	1	Yes	No	0	1	1	2
L:L:N227	L:L:N239	12.26	1	Yes	No	5	9	2	2
H:H:?5	L:L:N227	11.02	1	Yes	Yes	0	5	1	2
H:H:?5	L:L:N239	26.95	1	Yes	No	0	9	1	2
H:H:?5	H:H:?6	36.34	1	Yes	No	0	0	1	0
H:H:?6	H:H:?7	28.17	0	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	32.26
Average Nodes In Shell	6.00
Average Hubs In Shell	2.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:E209	L:L:P210	3.14	0	No	Yes	7	9	2	1
H:H:?9	L:L:E209	10.64	0	Yes	No	0	7	1	2
L:L:K250	L:L:P210	3.35	3	Yes	Yes	5	9	2	1
L:L:P210	L:L:P251	3.9	3	Yes	No	9	9	1	2
H:H:?8	L:L:P210	5.86	3	Yes	Yes	0	9	0	1
L:L:K250	L:L:P251	3.35	3	Yes	No	5	9	2	2
L:L:K250	L:L:N260	8.39	3	Yes	Yes	5	9	2	1
H:H:?22	L:L:K250	2.52	3	Yes	Yes	0	5	1	2
L:L:L259	L:L:V252	5.96	0	Yes	No	9	9	2	1
H:H:?8	L:L:V252	2.66	3	Yes	No	0	9	0	1
L:L:L259	L:L:S440	7.51	0	Yes	Yes	9	9	2	1
L:L:N260	L:L:S440	4.47	3	Yes	Yes	9	9	1	1
L:L:N260	L:L:N441	5.45	3	Yes	No	9	7	1	1
H:H:?8	L:L:N260	24.5	3	Yes	Yes	0	9	0	1
H:H:?22	L:L:N260	3.67	3	Yes	Yes	0	9	1	1
H:H:?22	L:L:P289	5.86	3	Yes	No	0	4	1	2
H:H:?22	L:L:D291	4.84	3	Yes	No	0	1	1	2
L:L:I292	L:L:S440	3.1	3	Yes	Yes	9	9	2	1
H:H:?9	L:L:S439	8.04	0	Yes	No	0	4	1	2
H:H:?8	L:L:S440	5.36	3	Yes	Yes	0	9	0	1
H:H:?8	L:L:N441	2.45	3	Yes	No	0	7	0	1
H:H:?22	L:L:N441	30.62	3	Yes	No	0	7	1	1
H:H:?8	H:H:?9	30.84	3	Yes	Yes	0	0	0	1
H:H:?22	H:H:?8	3.3	3	Yes	Yes	0	0	1	0
H:H:?10	H:H:?9	32.02	0	No	Yes	0	0	2	1
H:H:?22	H:H:?23	33.04	3	Yes	No	0	0	1	2

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	10.71
Average Nodes In Shell	18.00
Average Hubs In Shell	9.00
Average Links In Shell	26.00
Average Links Mediated by Hubs In Shell	26.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:E209	L:L:E61	3.81	0	No	Yes	7	9	1	2
L:L:E209	L:L:P210	3.14	0	No	Yes	7	9	1	2
H:H:?9	L:L:E209	10.64	0	Yes	No	0	7	0	1
H:H:?8	L:L:P210	5.86	3	Yes	Yes	0	9	1	2
H:H:?8	L:L:V252	2.66	3	Yes	No	0	9	1	2
L:L:N260	L:L:S440	4.47	3	Yes	Yes	9	9	2	2
L:L:N260	L:L:N441	5.45	3	Yes	No	9	7	2	2
H:H:?8	L:L:N260	24.5	3	Yes	Yes	0	9	1	2
H:H:?22	L:L:N260	3.67	3	Yes	Yes	0	9	2	2
L:L:N293	L:L:S439	2.98	0	No	No	5	4	2	1
H:H:?9	L:L:S439	8.04	0	Yes	No	0	4	0	1
H:H:?8	L:L:S440	5.36	3	Yes	Yes	0	9	1	2
H:H:?8	L:L:N441	2.45	3	Yes	No	0	7	1	2
H:H:?22	L:L:N441	30.62	3	Yes	No	0	7	2	2
H:H:?8	H:H:?9	30.84	3	Yes	Yes	0	0	1	0
H:H:?22	H:H:?8	3.3	3	Yes	Yes	0	0	2	1
H:H:?10	H:H:?9	32.02	0	No	Yes	0	0	1	0
H:H:?10	H:H:?31	39.86	0	No	Yes	0	0	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	20.38
Average Nodes In Shell	14.00
Average Hubs In Shell	8.00
Average Links In Shell	18.00
Average Links Mediated by Hubs In Shell	17.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:N274	L:L:N277	6.81	No	No	8	4	1	2
H:H:?11	L:L:N274	33.07	No	No	0	8	0	1
H:H:?11	H:H:?12	39.65	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	36.36
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?11	L:L:N274	33.07	0	No	No	0	8	1	2
H:H:?11	H:H:?12	39.65	0	No	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	39.65
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:N293	L:L:S439	2.98	0	No	No	5	4	1	2
H:H:?13	L:L:N293	25.72	0	Yes	No	0	5	0	1
H:H:?15	L:L:H327	2.29	22	Yes	No	0	5	1	2
L:L:N329	L:L:T406	4.39	22	No	No	5	4	2	2
H:H:?15	L:L:N329	28.17	22	Yes	No	0	5	1	2
L:L:Q334	L:L:S331	5.78	0	No	No	1	5	2	1
H:H:?15	L:L:T406	7.89	22	Yes	No	0	4	1	2
H:H:?13	H:H:?14	35.24	0	Yes	No	0	0	0	1
H:H:?13	H:H:?15	4.41	0	Yes	Yes	0	0	0	1
H:H:?15	H:H:?16	34.14	22	Yes	No	0	0	1	2
H:H:?13	L:L:S331	1.34	0	Yes	No	0	5	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	16.68
Average Nodes In Shell	11.00
Average Hubs In Shell	2.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?13	L:L:N293	25.72	Yes	No	5	1	2
H:H:?13	H:H:?14	35.24	Yes	No	0	1	0
H:H:?13	H:H:?15	4.41	Yes	Yes	0	1	2
H:H:?13	L:L:S331	1.34	Yes	No	5	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	35.24
Average Nodes In Shell	5.00
Average Hubs In Shell	2.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?13	L:L:N293	25.72	0	Yes	No	0	5	1	2
L:L:H327	L:L:T295	2.74	0	No	No	5	5	1	2
L:L:H327	L:L:P297	6.1	0	No	No	5	9	1	2
H:H:?15	L:L:H327	2.29	22	Yes	No	0	5	0	1
L:L:N329	L:L:T406	4.39	22	No	No	5	4	1	1
H:H:?15	L:L:N329	28.17	22	Yes	No	0	5	0	1
H:H:?15	L:L:T406	7.89	22	Yes	No	0	4	0	1
H:H:?13	H:H:?14	35.24	0	Yes	No	0	0	1	2
H:H:?13	H:H:?15	4.41	0	Yes	Yes	0	0	1	0
H:H:?15	H:H:?16	34.14	22	Yes	No	0	0	0	1
H:H:?16	H:H:?18	4.41	0	No	No	0	0	1	2
L:L:N329	L:L:T408	1.46	22	No	No	5	5	1	2
L:L:D405	L:L:T406	1.45	0	No	No	1	4	2	1
H:H:?13	L:L:S331	1.34	0	Yes	No	0	5	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	15.38
Average Nodes In Shell	14.00
Average Hubs In Shell	2.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?15	L:L:H327	2.29	22	Yes	No	0	5	1	2
L:L:N329	L:L:T406	4.39	22	No	No	5	4	2	2
H:H:?15	L:L:N329	28.17	22	Yes	No	0	5	1	2
H:H:?15	L:L:T406	7.89	22	Yes	No	0	4	1	2
H:H:?13	H:H:?15	4.41	0	Yes	Yes	0	0	2	1
H:H:?15	H:H:?16	34.14	22	Yes	No	0	0	1	0
H:H:?16	H:H:?18	4.41	0	No	No	0	0	0	1
H:H:?17	H:H:?18	31.94	21	Yes	No	0	0	2	1
H:H:?18	H:H:?19	29.45	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	19.27
Average Nodes In Shell	9.00
Average Hubs In Shell	3.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:N299	L:L:P297	4.89	21	No	No	9	9	1	1
L:L:H327	L:L:P297	6.1	0	No	No	5	9	2	1
H:H:?17	L:L:P297	14.65	21	Yes	No	0	9	0	1
H:H:?17	L:L:N299	23.27	21	Yes	No	0	9	0	1
L:L:D322	L:L:Q325	5.22	0	No	No	5	4	2	1
H:H:?17	L:L:Q325	2.37	21	Yes	No	0	4	0	1
H:H:?16	H:H:?18	4.41	0	No	No	0	0	2	1
H:H:?17	H:H:?18	31.94	21	Yes	No	0	0	0	1
H:H:?18	H:H:?19	29.45	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.06
Average Nodes In Shell	9.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:N299	L:L:P297	4.89	21	No	No	9	9	2	2
H:H:?17	L:L:P297	14.65	21	Yes	No	0	9	1	2
H:H:?17	L:L:N299	23.27	21	Yes	No	0	9	1	2
H:H:?17	L:L:Q325	2.37	21	Yes	No	0	4	1	2
H:H:?15	H:H:?16	34.14	22	Yes	No	0	0	2	1
H:H:?16	H:H:?18	4.41	0	No	No	0	0	1	0
H:H:?17	H:H:?18	31.94	21	Yes	No	0	0	1	0
H:H:?18	H:H:?19	29.45	0	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	21.93
Average Nodes In Shell	8.00
Average Hubs In Shell	2.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:F369	L:L:V368	3.93	11	No	No	5	6	1	2
L:L:F369	L:L:N382	10.87	11	No	Yes	5	7	1	1
H:H:?20	L:L:F369	11.95	11	Yes	No	0	5	0	1
L:L:N382	L:L:T384	7.31	11	Yes	No	7	5	1	1
L:L:N382	L:L:P410	6.52	11	Yes	No	7	4	1	2
H:H:?20	L:L:N382	25.72	11	Yes	Yes	0	7	0	1
H:H:?20	L:L:T384	14.46	11	Yes	No	0	5	0	1
H:H:?20	H:H:?21	35.24	11	Yes	No	0	0	0	1
H:H:?21	H:H:?30	8.81	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	21.84
Average Nodes In Shell	8.00
Average Hubs In Shell	2.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:F369	L:L:N382	10.87	11	No	Yes	5	7	2	2
H:H:?20	L:L:F369	11.95	11	Yes	No	0	5	1	2
L:L:N382	L:L:T384	7.31	11	Yes	No	7	5	2	2
H:H:?20	L:L:N382	25.72	11	Yes	Yes	0	7	1	2
H:H:?20	L:L:T384	14.46	11	Yes	No	0	5	1	2
H:H:?30	L:L:N388	23.27	0	No	No	0	8	1	2
H:H:?20	H:H:?21	35.24	11	Yes	No	0	0	1	0
H:H:?21	H:H:?30	8.81	0	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	22.03
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:K250	L:L:P210	3.35	3	Yes	Yes	5	9	1	2
L:L:P210	L:L:P251	3.9	3	Yes	No	9	9	2	2
H:H:?8	L:L:P210	5.86	3	Yes	Yes	0	9	1	2
L:L:K250	L:L:P212	5.02	3	Yes	No	5	9	1	2
L:L:K250	L:L:P251	3.35	3	Yes	No	5	9	1	2
L:L:K250	L:L:N260	8.39	3	Yes	Yes	5	9	1	1
H:H:?22	L:L:K250	2.52	3	Yes	Yes	0	5	0	1
H:H:?8	L:L:V252	2.66	3	Yes	No	0	9	1	2
L:L:N260	L:L:S440	4.47	3	Yes	Yes	9	9	1	2
L:L:N260	L:L:N441	5.45	3	Yes	No	9	7	1	1
H:H:?8	L:L:N260	24.5	3	Yes	Yes	0	9	1	1
H:H:?22	L:L:N260	3.67	3	Yes	Yes	0	9	0	1
L:L:L263	L:L:P289	6.57	0	No	No	8	4	2	1
H:H:?22	L:L:P289	5.86	3	Yes	No	0	4	0	1
H:H:?22	L:L:D291	4.84	3	Yes	No	0	1	0	1
H:H:?8	L:L:S440	5.36	3	Yes	Yes	0	9	1	2
H:H:?8	L:L:N441	2.45	3	Yes	No	0	7	1	1
H:H:?22	L:L:N441	30.62	3	Yes	No	0	7	0	1
H:H:?8	H:H:?9	30.84	3	Yes	Yes	0	0	1	2
H:H:?22	H:H:?8	3.3	3	Yes	Yes	0	0	0	1
H:H:?22	H:H:?23	33.04	3	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	11.98
Average Nodes In Shell	15.00
Average Hubs In Shell	7.00
Average Links In Shell	21.00
Average Links Mediated by Hubs In Shell	20.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:K250	L:L:N260	8.39	3	Yes	Yes	5	9	2	2
H:H:?22	L:L:K250	2.52	3	Yes	Yes	0	5	1	2
L:L:N260	L:L:N441	5.45	3	Yes	No	9	7	2	2
H:H:?8	L:L:N260	24.5	3	Yes	Yes	0	9	2	2
H:H:?22	L:L:N260	3.67	3	Yes	Yes	0	9	1	2
H:H:?22	L:L:P289	5.86	3	Yes	No	0	4	1	2
H:H:?22	L:L:D291	4.84	3	Yes	No	0	1	1	2
H:H:?8	L:L:N441	2.45	3	Yes	No	0	7	2	2
H:H:?22	L:L:N441	30.62	3	Yes	No	0	7	1	2
H:H:?22	H:H:?8	3.3	3	Yes	Yes	0	0	1	2
H:H:?22	H:H:?23	33.04	3	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	33.04
Average Nodes In Shell	8.00
Average Hubs In Shell	4.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:E84	L:L:N85	13.15	18	No	No	1	9	1	1
H:H:?24	L:L:E84	22.46	18	No	No	0	1	0	1
H:H:?24	L:L:N85	24.5	18	No	No	0	9	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	23.48
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?25	L:L:N336	28.17	4	No	No	0	4	0	1
L:L:F357	L:L:L339	2.44	4	Yes	No	9	8	2	2
L:L:L339	L:L:W391	4.56	4	No	Yes	8	3	2	1
L:L:S340	L:L:T395	3.2	0	No	No	1	1	2	1
L:L:I355	L:L:V343	3.07	4	Yes	No	9	3	2	2
L:L:F357	L:L:V343	2.62	4	Yes	No	9	3	2	2
L:L:V343	L:L:W391	6.13	4	No	Yes	3	3	2	1
L:L:F357	L:L:I355	3.77	4	Yes	Yes	9	9	2	2
L:L:I355	L:L:W391	2.35	4	Yes	Yes	9	3	2	1
L:L:F357	L:L:W391	4.01	4	Yes	Yes	9	3	2	1
L:L:S389	L:L:W391	4.94	0	No	Yes	5	3	2	1
L:L:T395	L:L:W391	4.85	4	No	Yes	1	3	1	1
H:H:?25	L:L:W391	5.08	4	No	Yes	0	3	0	1
H:H:?25	L:L:T395	6.57	4	No	No	0	1	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	13.27
Average Nodes In Shell	10.00
Average Hubs In Shell	3.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:N352	L:L:R347	7.23	23	No	No	5	3	1	1
H:H:?26	L:L:R347	2.17	23	No	No	0	3	0	1
H:H:?26	L:L:N352	29.4	23	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.79
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:N393	L:L:N394	8.17	24	No	No	1	4	1	1
H:H:?27	L:L:N393	24.5	24	No	No	0	1	0	1
H:H:?27	L:L:N394	9.8	24	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	17.15
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?28	L:L:M456	7.57	0	No	No	0	1	0	1
H:H:?28	L:L:N457	24.5	0	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	16.04
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?29	L:L:N195	26.95	No	No	0	9	0	1
L:L:S197	L:L:T120	1.6	No	No	9	9	1	2
L:L:L122	L:L:N195	1.37	No	No	9	9	2	1
H:H:?29	L:L:S197	1.34	No	No	0	9	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.14
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MEO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?30	L:L:N388	23.27	0	No	No	8	0	1
H:H:?20	H:H:?21	35.24	11	Yes	No	0	2	1
H:H:?21	H:H:?30	8.81	0	No	No	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	16.04
Average Nodes In Shell	4.00
Average Hubs In Shell	1.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6MET

Protein

Chemokine

CCR5

Homo sapiens

Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4

4.5

2018-12-12

10.1038/s41586-018-0804-9

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:N91	L:L:T234	5.85	No	No	8	5	2	1
L:L:T234	L:L:W93	9.7	No	Yes	5	9	1	2
L:L:G235	L:L:N232	3.39	No	No	9	6	2	1
H:H:?1	L:L:N232	25.72	No	No	0	6	0	1
H:H:?1	H:H:?2	35.24	No	No	0	0	0	1
H:H:?1	L:L:T234	1.31	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	20.76
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?1	L:L:N232	25.72	No	No	6	1	2
H:H:?1	H:H:?2	35.24	No	No	0	1	0
H:H:?1	L:L:T234	1.31	No	No	5	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	35.24
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:E80	L:L:N227	3.94	1	No	Yes	9	5	2	1
L:L:E80	L:L:S241	8.62	1	No	No	9	9	2	2
L:L:S241	L:L:V82	3.23	1	No	No	9	1	2	1
H:H:?3	L:L:V82	3.99	1	Yes	No	0	1	0	1
L:L:K225	L:L:N227	2.8	1	No	Yes	8	5	2	1
L:L:N227	L:L:N239	12.26	1	Yes	No	5	9	1	1
L:L:N227	L:L:S241	5.96	1	Yes	No	5	9	1	2
H:H:?3	L:L:N227	11.02	1	Yes	Yes	0	5	0	1
H:H:?3	L:L:N239	26.95	1	Yes	No	0	9	0	1
H:H:?3	H:H:?4	36.34	1	Yes	No	0	0	0	1
H:H:?4	H:H:?5	28.17	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	19.58
Average Nodes In Shell	9.00
Average Hubs In Shell	2.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	L:L:V82	3.99	1	Yes	No	0	1	1	2
L:L:N227	L:L:N239	12.26	1	Yes	No	5	9	2	2
H:H:?3	L:L:N227	11.02	1	Yes	Yes	0	5	1	2
H:H:?3	L:L:N239	26.95	1	Yes	No	0	9	1	2
H:H:?3	H:H:?4	36.34	1	Yes	No	0	0	1	0
H:H:?4	H:H:?5	28.17	0	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	32.26
Average Nodes In Shell	6.00
Average Hubs In Shell	2.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:E209	L:L:P210	3.14	0	No	Yes	7	9	2	1
H:H:?7	L:L:E209	10.64	2	Yes	No	0	7	1	2
L:L:K250	L:L:P210	3.35	2	Yes	Yes	5	9	2	1
L:L:P210	L:L:P251	3.9	2	Yes	No	9	9	1	2
L:L:P210	L:L:V252	1.77	2	Yes	No	9	9	1	1
H:H:?6	L:L:P210	5.86	2	Yes	Yes	0	9	0	1
L:L:K250	L:L:P251	3.35	2	Yes	No	5	9	2	2
L:L:K250	L:L:N260	8.39	2	Yes	Yes	5	9	2	1
H:H:?20	L:L:K250	2.52	2	Yes	Yes	0	5	1	2
L:L:L259	L:L:V252	5.96	0	Yes	No	9	9	2	1
H:H:?6	L:L:V252	2.66	2	Yes	No	0	9	0	1
L:L:L259	L:L:S440	7.51	0	Yes	Yes	9	9	2	1
L:L:N260	L:L:S440	4.47	2	Yes	Yes	9	9	1	1
L:L:N260	L:L:N441	5.45	2	Yes	No	9	7	1	1
H:H:?6	L:L:N260	24.5	2	Yes	Yes	0	9	0	1
H:H:?20	L:L:N260	3.67	2	Yes	Yes	0	9	1	1
H:H:?20	L:L:P289	5.86	2	Yes	No	0	4	1	2
H:H:?20	L:L:D291	4.84	2	Yes	No	0	1	1	2
L:L:I292	L:L:S440	3.1	2	Yes	Yes	9	9	2	1
H:H:?7	L:L:S439	8.04	2	Yes	No	0	4	1	2
H:H:?6	L:L:S440	5.36	2	Yes	Yes	0	9	0	1
H:H:?6	L:L:N441	2.45	2	Yes	No	0	7	0	1
H:H:?20	L:L:N441	30.62	2	Yes	No	0	7	1	1
H:H:?6	H:H:?7	30.84	2	Yes	Yes	0	0	0	1
H:H:?20	H:H:?6	3.3	2	Yes	Yes	0	0	1	0
H:H:?7	H:H:?8	32.02	2	Yes	No	0	0	1	2
H:H:?31	H:H:?7	3.81	2	No	Yes	0	0	2	1
H:H:?31	H:H:?8	22.14	2	No	No	0	0	2	2
H:H:?20	H:H:?21	33.04	2	Yes	No	0	0	1	2

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	10.71
Average Nodes In Shell	19.00
Average Hubs In Shell	9.00
Average Links In Shell	29.00
Average Links Mediated by Hubs In Shell	28.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:E209	L:L:E61	3.81	0	No	Yes	7	9	1	2
L:L:E209	L:L:P210	3.14	0	No	Yes	7	9	1	2
H:H:?7	L:L:E209	10.64	2	Yes	No	0	7	0	1
L:L:P210	L:L:V252	1.77	2	Yes	No	9	9	2	2
H:H:?6	L:L:P210	5.86	2	Yes	Yes	0	9	1	2
H:H:?6	L:L:V252	2.66	2	Yes	No	0	9	1	2
L:L:N260	L:L:S440	4.47	2	Yes	Yes	9	9	2	2
L:L:N260	L:L:N441	5.45	2	Yes	No	9	7	2	2
H:H:?6	L:L:N260	24.5	2	Yes	Yes	0	9	1	2
H:H:?20	L:L:N260	3.67	2	Yes	Yes	0	9	2	2
L:L:N293	L:L:S439	2.98	0	No	No	5	4	2	1
H:H:?7	L:L:S439	8.04	2	Yes	No	0	4	0	1
H:H:?6	L:L:S440	5.36	2	Yes	Yes	0	9	1	2
H:H:?6	L:L:N441	2.45	2	Yes	No	0	7	1	2
H:H:?20	L:L:N441	30.62	2	Yes	No	0	7	2	2
H:H:?6	H:H:?7	30.84	2	Yes	Yes	0	0	1	0
H:H:?20	H:H:?6	3.3	2	Yes	Yes	0	0	2	1
H:H:?7	H:H:?8	32.02	2	Yes	No	0	0	0	1
H:H:?31	H:H:?7	3.81	2	No	Yes	0	0	1	0
H:H:?29	H:H:?8	38.38	0	No	No	0	0	2	1
H:H:?31	H:H:?8	22.14	2	No	No	0	0	1	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	17.07
Average Nodes In Shell	15.00
Average Hubs In Shell	7.00
Average Links In Shell	21.00
Average Links Mediated by Hubs In Shell	18.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:N274	L:L:N277	5.45	26	No	No	8	4	1	1
H:H:?9	L:L:N274	33.07	26	No	No	0	8	0	1
H:H:?9	L:L:N277	12.25	26	No	No	0	4	0	1
H:H:?10	H:H:?9	39.65	0	No	No	0	0	1	0
L:L:N277	M:M:K54	1.4	26	No	No	4	8	1	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	28.32
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:N274	L:L:N277	5.45	26	No	No	8	4	2	2
H:H:?9	L:L:N274	33.07	26	No	No	0	8	1	2
H:H:?9	L:L:N277	12.25	26	No	No	0	4	1	2
H:H:?10	H:H:?9	39.65	0	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	39.65
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:N293	L:L:S439	2.98	0	No	No	5	4	1	2
H:H:?11	L:L:N293	25.72	0	Yes	No	0	5	0	1
H:H:?13	L:L:H327	2.29	28	Yes	No	0	5	1	2
L:L:N329	L:L:T406	4.39	28	No	No	5	4	2	2
H:H:?13	L:L:N329	28.17	28	Yes	No	0	5	1	2
L:L:Q334	L:L:S331	5.78	0	No	No	1	5	2	1
H:H:?13	L:L:T406	7.89	28	Yes	No	0	4	1	2
H:H:?11	H:H:?12	35.24	0	Yes	No	0	0	0	1
H:H:?11	H:H:?13	4.41	0	Yes	Yes	0	0	0	1
H:H:?13	H:H:?14	34.14	28	Yes	No	0	0	1	2
H:H:?11	L:L:S331	1.34	0	Yes	No	0	5	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	16.68
Average Nodes In Shell	11.00
Average Hubs In Shell	2.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?11	L:L:N293	25.72	Yes	No	5	1	2
H:H:?11	H:H:?12	35.24	Yes	No	0	1	0
H:H:?11	H:H:?13	4.41	Yes	Yes	0	1	2
H:H:?11	L:L:S331	1.34	Yes	No	5	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	35.24
Average Nodes In Shell	5.00
Average Hubs In Shell	2.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?11	L:L:N293	25.72	0	Yes	No	0	5	1	2
L:L:H327	L:L:T295	2.74	0	No	No	5	5	1	2
L:L:H327	L:L:P297	6.1	0	No	No	5	9	1	2
H:H:?13	L:L:H327	2.29	28	Yes	No	0	5	0	1
L:L:N329	L:L:T406	4.39	28	No	No	5	4	1	1
H:H:?13	L:L:N329	28.17	28	Yes	No	0	5	0	1
H:H:?13	L:L:T406	7.89	28	Yes	No	0	4	0	1
H:H:?11	H:H:?12	35.24	0	Yes	No	0	0	1	2
H:H:?11	H:H:?13	4.41	0	Yes	Yes	0	0	1	0
H:H:?13	H:H:?14	34.14	28	Yes	No	0	0	0	1
H:H:?14	H:H:?16	4.41	0	No	No	0	0	1	2
L:L:N329	L:L:T408	1.46	28	No	No	5	5	1	2
L:L:D405	L:L:T406	1.45	0	No	No	1	4	2	1
H:H:?11	L:L:S331	1.34	0	Yes	No	0	5	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	15.38
Average Nodes In Shell	14.00
Average Hubs In Shell	2.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?13	L:L:H327	2.29	28	Yes	No	0	5	1	2
L:L:N329	L:L:T406	4.39	28	No	No	5	4	2	2
H:H:?13	L:L:N329	28.17	28	Yes	No	0	5	1	2
H:H:?13	L:L:T406	7.89	28	Yes	No	0	4	1	2
H:H:?11	H:H:?13	4.41	0	Yes	Yes	0	0	2	1
H:H:?13	H:H:?14	34.14	28	Yes	No	0	0	1	0
H:H:?14	H:H:?16	4.41	0	No	No	0	0	0	1
H:H:?15	H:H:?16	31.94	27	Yes	No	0	0	2	1
H:H:?16	H:H:?17	29.45	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	19.27
Average Nodes In Shell	9.00
Average Hubs In Shell	3.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:N299	L:L:P297	4.89	27	No	No	9	9	1	1
L:L:H327	L:L:P297	6.1	0	No	No	5	9	2	1
H:H:?15	L:L:P297	14.65	27	Yes	No	0	9	0	1
H:H:?15	L:L:N299	23.27	27	Yes	No	0	9	0	1
L:L:D322	L:L:Q325	5.22	0	No	No	5	4	2	1
H:H:?15	L:L:Q325	2.37	27	Yes	No	0	4	0	1
H:H:?14	H:H:?16	4.41	0	No	No	0	0	2	1
H:H:?15	H:H:?16	31.94	27	Yes	No	0	0	0	1
H:H:?16	H:H:?17	29.45	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.06
Average Nodes In Shell	9.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:N299	L:L:P297	4.89	27	No	No	9	9	2	2
H:H:?15	L:L:P297	14.65	27	Yes	No	0	9	1	2
H:H:?15	L:L:N299	23.27	27	Yes	No	0	9	1	2
H:H:?15	L:L:Q325	2.37	27	Yes	No	0	4	1	2
H:H:?13	H:H:?14	34.14	28	Yes	No	0	0	2	1
H:H:?14	H:H:?16	4.41	0	No	No	0	0	1	0
H:H:?15	H:H:?16	31.94	27	Yes	No	0	0	1	0
H:H:?16	H:H:?17	29.45	0	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	21.93
Average Nodes In Shell	8.00
Average Hubs In Shell	2.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:F369	L:L:V368	3.93	12	No	Yes	5	6	1	2
L:L:F369	L:L:N382	10.87	12	No	Yes	5	7	1	1
H:H:?18	L:L:F369	15.21	12	Yes	No	0	5	0	1
L:L:N382	L:L:T384	10.24	12	Yes	No	7	5	1	1
L:L:N382	L:L:P410	6.52	12	Yes	No	7	4	1	2
H:H:?18	L:L:N382	22.05	12	Yes	Yes	0	7	0	1
H:H:?18	L:L:T384	21.04	12	Yes	No	0	5	0	1
H:H:?18	H:H:?19	34.14	12	Yes	No	0	0	0	1
H:H:?19	H:H:?28	17.62	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	23.11
Average Nodes In Shell	8.00
Average Hubs In Shell	3.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:F369	L:L:N382	10.87	12	No	Yes	5	7	2	2
H:H:?18	L:L:F369	15.21	12	Yes	No	0	5	1	2
L:L:N382	L:L:T384	10.24	12	Yes	No	7	5	2	2
H:H:?18	L:L:N382	22.05	12	Yes	Yes	0	7	1	2
H:H:?18	L:L:T384	21.04	12	Yes	No	0	5	1	2
H:H:?28	L:L:N388	23.27	0	No	No	0	8	1	2
H:H:?18	H:H:?19	34.14	12	Yes	No	0	0	1	0
H:H:?19	H:H:?28	17.62	0	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	25.88
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:K250	L:L:P210	3.35	2	Yes	Yes	5	9	1	2
L:L:P210	L:L:P251	3.9	2	Yes	No	9	9	2	2
L:L:P210	L:L:V252	1.77	2	Yes	No	9	9	2	2
H:H:?6	L:L:P210	5.86	2	Yes	Yes	0	9	1	2
L:L:K250	L:L:P212	5.02	2	Yes	No	5	9	1	2
L:L:K250	L:L:P251	3.35	2	Yes	No	5	9	1	2
L:L:K250	L:L:N260	8.39	2	Yes	Yes	5	9	1	1
H:H:?20	L:L:K250	2.52	2	Yes	Yes	0	5	0	1
H:H:?6	L:L:V252	2.66	2	Yes	No	0	9	1	2
L:L:N260	L:L:S440	4.47	2	Yes	Yes	9	9	1	2
L:L:N260	L:L:N441	5.45	2	Yes	No	9	7	1	1
H:H:?6	L:L:N260	24.5	2	Yes	Yes	0	9	1	1
H:H:?20	L:L:N260	3.67	2	Yes	Yes	0	9	0	1
L:L:L263	L:L:P289	6.57	0	No	No	8	4	2	1
H:H:?20	L:L:P289	5.86	2	Yes	No	0	4	0	1
H:H:?20	L:L:D291	4.84	2	Yes	No	0	1	0	1
H:H:?6	L:L:S440	5.36	2	Yes	Yes	0	9	1	2
H:H:?6	L:L:N441	2.45	2	Yes	No	0	7	1	1
H:H:?20	L:L:N441	30.62	2	Yes	No	0	7	0	1
H:H:?6	H:H:?7	30.84	2	Yes	Yes	0	0	1	2
H:H:?20	H:H:?6	3.3	2	Yes	Yes	0	0	0	1
H:H:?20	H:H:?21	33.04	2	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	11.98
Average Nodes In Shell	15.00
Average Hubs In Shell	7.00
Average Links In Shell	22.00
Average Links Mediated by Hubs In Shell	21.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:K250	L:L:N260	8.39	2	Yes	Yes	5	9	2	2
H:H:?20	L:L:K250	2.52	2	Yes	Yes	0	5	1	2
L:L:N260	L:L:N441	5.45	2	Yes	No	9	7	2	2
H:H:?6	L:L:N260	24.5	2	Yes	Yes	0	9	2	2
H:H:?20	L:L:N260	3.67	2	Yes	Yes	0	9	1	2
H:H:?20	L:L:P289	5.86	2	Yes	No	0	4	1	2
H:H:?20	L:L:D291	4.84	2	Yes	No	0	1	1	2
H:H:?6	L:L:N441	2.45	2	Yes	No	0	7	2	2
H:H:?20	L:L:N441	30.62	2	Yes	No	0	7	1	2
H:H:?20	H:H:?6	3.3	2	Yes	Yes	0	0	1	2
H:H:?20	H:H:?21	33.04	2	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	33.04
Average Nodes In Shell	8.00
Average Hubs In Shell	4.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:E84	L:L:N85	13.15	23	No	No	1	9	1	1
H:H:?22	L:L:E84	22.46	23	No	No	0	1	0	1
H:H:?22	L:L:N85	24.5	23	No	No	0	9	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	23.48
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?23	L:L:N336	28.17	5	No	No	0	4	0	1
L:L:F357	L:L:L339	2.44	5	Yes	No	9	8	2	2
L:L:L339	L:L:W391	4.56	5	No	Yes	8	3	2	1
L:L:S340	L:L:T395	3.2	0	No	No	1	1	2	1
L:L:I355	L:L:V343	3.07	5	Yes	No	9	3	2	2
L:L:F357	L:L:V343	2.62	5	Yes	No	9	3	2	2
L:L:V343	L:L:W391	6.13	5	No	Yes	3	3	2	1
L:L:F357	L:L:I355	3.77	5	Yes	Yes	9	9	2	2
L:L:I355	L:L:W391	2.35	5	Yes	Yes	9	3	2	1
L:L:F357	L:L:W391	4.01	5	Yes	Yes	9	3	2	1
L:L:S389	L:L:W391	4.94	0	No	Yes	5	3	2	1
L:L:T395	L:L:W391	4.85	5	No	Yes	1	3	1	1
H:H:?23	L:L:W391	5.08	5	No	Yes	0	3	0	1
H:H:?23	L:L:T395	6.57	5	No	No	0	1	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	13.27
Average Nodes In Shell	10.00
Average Hubs In Shell	3.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:N352	L:L:R347	7.23	29	No	No	5	3	1	1
H:H:?24	L:L:R347	2.17	29	No	No	0	3	0	1
H:H:?24	L:L:N352	29.4	29	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.79
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:N393	L:L:N394	8.17	30	No	No	1	4	1	1
H:H:?25	L:L:N393	24.5	30	No	No	0	1	0	1
H:H:?25	L:L:N394	9.8	30	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	17.15
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?26	L:L:M456	7.57	0	No	No	0	1	0	1
H:H:?26	L:L:N457	24.5	0	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	16.04
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?27	L:L:N195	26.95	No	No	0	9	0	1
L:L:S197	L:L:T120	1.6	No	No	9	9	1	2
L:L:L122	L:L:N195	1.37	No	No	9	9	2	1
H:H:?27	L:L:S197	1.34	No	No	0	9	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.14
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6MET
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?28	L:L:N388	23.27	0	No	No	8	0	1
H:H:?18	H:H:?19	34.14	12	Yes	No	0	2	1
H:H:?19	H:H:?28	17.62	0	No	No	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	20.45
Average Nodes In Shell	4.00
Average Hubs In Shell	1.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6N51

Aminoacid

Metabotropic glutamate

mGlu5; mGlu5

Homo sapiens

Quisqualate

2019-01-23

10.1038/s41586-019-0881-4

A 2D representation of the interactions of NAG in 6N51
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	S:S:N210	25.72	0	No	No	0	4	0	1
S:S:N210	S:S:R508	1.21	0	No	No	4	1	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	25.72
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6N51
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N445	S:S:T453	4.39	0	No	No	5	3	1	2
H:H:?2	S:S:N445	26.95	0	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	26.95
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6N51
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:N210	25.72	0	No	No	0	4	0	1
R:R:N210	R:R:R508	1.21	0	No	No	4	1	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	25.72
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6N51
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N445	R:R:T453	4.39	0	No	No	5	3	1	2
H:H:?4	R:R:N445	26.95	0	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	26.95
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6N52

Aminoacid

Metabotropic glutamate

mGlu5; mGlu5

Homo sapiens

2019-01-23

10.1038/s41586-019-0881-4

A 2D representation of the interactions of NAG in 6N52
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N210	R:R:R508	7.23	No	No	4	1	1	2
H:H:?1	R:R:N210	23.27	No	No	0	4	0	1
R:R:N505	R:R:W500	10.17	No	Yes	4	7	1	2
H:H:?1	R:R:N505	3.67	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.47
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6N52
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L455	R:R:N445	5.49	No	No	3	5	2	1
H:H:?2	R:R:N445	25.72	No	No	0	5	0	1
R:R:N445	R:R:T453	1.46	No	No	5	3	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	25.72
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6N52
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N210	S:S:R508	7.23	0	No	No	4	1	1	2
H:H:?3	S:S:N210	26.95	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	26.95
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6N52
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:L455	S:S:N445	5.49	No	No	3	5	2	1
H:H:?4	S:S:N445	26.95	No	No	0	5	0	1
S:S:N445	S:S:T453	1.46	No	No	5	3	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	26.95
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6NWE

Sensory

Opsins

Rhodopsin

Bos taurus

Octyl Beta-D-Glucopyranoside

Gt(CT)

2.71

2020-02-12

To be published

A 2D representation of the interactions of NAG in 6NWE
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	7.31	1	Yes	No	7	6	1	1
R:R:T4	R:R:V20	11.11	1	No	Yes	6	6	1	2
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	0	1
R:R:G18	R:R:N15	5.09	1	No	Yes	3	7	1	1
R:R:N15	R:R:V20	10.35	1	Yes	Yes	7	6	1	2
H:H:?1	R:R:N15	25.72	1	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	0	1
H:H:?2	R:R:R21	6.5	0	No	No	0	4	1	2
H:H:?1	H:H:?2	40.75	1	Yes	No	0	0	0	1
H:H:?2	H:H:?3	29.45	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	19.46
Average Nodes In Shell	8.00
Average Hubs In Shell	3.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6NWE
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	7.31	1	Yes	No	7	6	2	2
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	1	2
R:R:G18	R:R:N15	5.09	1	No	Yes	3	7	2	2
H:H:?1	R:R:N15	25.72	1	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	1	2
H:H:?2	R:R:R21	6.5	0	No	No	0	4	0	1
H:H:?1	H:H:?2	40.75	1	Yes	No	0	0	1	0
H:H:?2	H:H:?3	29.45	0	No	No	0	0	0	1
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	25.57
Average Nodes In Shell	8.00
Average Hubs In Shell	2.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6O3C

Protein

Frizzled

SMO

Mus musculus

SAG21k

Cholesterol

2.8

2019-07-03

10.1038/s41586-019-1355-4

A 2D representation of the interactions of NAG in 6O3C
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N80	R:R:V81	4.43	0	No	No	5	5	1	2
H:H:?1	R:R:N80	36.74	0	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	36.74
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6O3C
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D99	R:R:K109	11.06	2	Yes	Yes	6	4	2	2
R:R:D99	W:W:?2	6.81	2	Yes	Yes	6	0	2	1
R:R:K109	W:W:?2	4.25	2	Yes	Yes	4	0	2	1
R:R:L112	W:W:?2	9.73	2	No	Yes	4	0	1	1
H:H:?2	R:R:L112	4.94	2	Yes	No	0	4	0	1
R:R:V161	R:R:W113	3.68	2	No	Yes	6	7	2	2
R:R:W113	W:W:?2	34.3	2	Yes	Yes	7	0	2	1
R:R:L116	W:W:?2	11.12	0	No	Yes	9	0	2	1
R:R:V161	W:W:?2	4.49	2	No	Yes	6	0	2	1
R:R:E164	R:R:L493	11.93	2	No	No	4	4	2	2
R:R:E164	W:W:?2	3.99	2	No	Yes	4	0	2	1
R:R:R165	W:W:?2	13.42	2	No	Yes	4	0	1	1
H:H:?2	R:R:R165	4.33	2	Yes	No	0	4	0	1
R:R:L493	W:W:?2	4.17	2	No	Yes	4	0	2	1
R:R:A496	W:W:?2	4.75	0	No	Yes	5	0	2	1
H:H:?2	R:R:N497	29.4	2	Yes	No	0	5	0	1
H:H:?2	W:W:?2	6.2	2	Yes	Yes	0	0	0	1
R:R:G115	W:W:?2	1.72	0	No	Yes	6	0	2	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	11.22
Average Nodes In Shell	14.00
Average Hubs In Shell	5.00
Average Links In Shell	18.00
Average Links Mediated by Hubs In Shell	17.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6OS0

Peptide

Angiotensin

AT1

Homo sapiens

Angiotensinogen

2.9

2020-02-19

10.1126/science.aay9813

A 2D representation of the interactions of NAG in 6OS0
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F171	R:R:N176	7.25	0	Yes	No	6	5	2	1
H:H:?1	R:R:N176	30.62	0	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	30.62
Average Nodes In Shell	3.00
Average Hubs In Shell	1.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6OS2

Peptide

Angiotensin

AT1

Homo sapiens

TRV026

2.7

2020-02-19

10.1126/science.aay9813

A 2D representation of the interactions of NAG in 6OS2
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F171	R:R:N176	4.83	0	Yes	No	6	5	2	1
H:H:?1	R:R:N176	28.17	0	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	28.17
Average Nodes In Shell	3.00
Average Hubs In Shell	1.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6PEL

Sensory

Opsins

Rhodopsin

Bos taurus

Citronellol

Gt(CT)

3.19

2020-06-24

To be published

A 2D representation of the interactions of NAG in 6PEL
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:G3	R:R:T4	3.64	0	No	Yes	6	6	2	1
R:R:N15	R:R:T4	8.77	2	No	Yes	7	6	1	1
R:R:T4	R:R:V20	14.28	2	Yes	Yes	6	6	1	1
H:H:?1	R:R:T4	5.26	2	Yes	Yes	0	6	0	1
R:R:V11	R:R:V20	4.81	2	No	Yes	8	6	2	1
R:R:V11	R:R:Y30	5.05	2	No	Yes	8	4	2	2
R:R:F13	R:R:V20	3.93	2	No	Yes	4	6	2	1
R:R:F13	R:R:Y30	11.35	2	No	Yes	4	4	2	2
R:R:N15	R:R:V20	10.35	2	No	Yes	7	6	1	1
H:H:?1	R:R:N15	24.5	2	Yes	No	0	7	0	1
H:H:?1	R:R:G18	7.63	2	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	8.83	2	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	3.99	2	Yes	Yes	0	6	0	1
H:H:?1	R:R:R21	5.42	2	Yes	No	0	4	0	1
H:H:?2	R:R:R21	7.59	2	No	No	0	4	1	1
H:H:?1	H:H:?2	34.14	2	Yes	No	0	0	0	1
H:H:?2	H:H:?3	26.89	2	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	13.49
Average Nodes In Shell	13.00
Average Hubs In Shell	4.00
Average Links In Shell	18.00
Average Links Mediated by Hubs In Shell	15.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6PEL
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	8.77	2	No	Yes	7	6	2	2
R:R:T4	R:R:V20	14.28	2	Yes	Yes	6	6	2	2
H:H:?1	R:R:T4	5.26	2	Yes	Yes	0	6	1	2
R:R:N15	R:R:V20	10.35	2	No	Yes	7	6	2	2
H:H:?1	R:R:N15	24.5	2	Yes	No	0	7	1	2
H:H:?1	R:R:G18	7.63	2	Yes	No	0	3	1	2
H:H:?1	R:R:V20	3.99	2	Yes	Yes	0	6	1	2
H:H:?1	R:R:R21	5.42	2	Yes	No	0	4	1	1
H:H:?2	R:R:R21	7.59	2	No	No	0	4	0	1
H:H:?1	H:H:?2	34.14	2	Yes	No	0	0	1	0
H:H:?2	H:H:?3	26.89	2	No	No	0	0	0	1
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	22.87
Average Nodes In Shell	9.00
Average Hubs In Shell	3.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6PGS

Sensory

Opsins

Rhodopsin

Bos taurus

Geraniol

Gt(CT)

2.9

2020-07-01

To be published

A 2D representation of the interactions of NAG in 6PGS
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	7.31	1	Yes	No	7	6	1	1
R:R:T4	R:R:V20	11.11	1	No	Yes	6	6	1	1
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	0	1
R:R:V11	R:R:V20	4.81	1	Yes	Yes	8	6	2	1
R:R:V11	R:R:Y30	5.05	1	Yes	Yes	8	4	2	2
R:R:F13	R:R:V20	5.24	1	No	Yes	4	6	2	1
R:R:F13	R:R:Y30	8.25	1	No	Yes	4	4	2	2
R:R:G18	R:R:N15	3.39	1	No	Yes	3	7	1	1
R:R:N15	R:R:V20	10.35	1	Yes	Yes	7	6	1	1
H:H:?1	R:R:N15	25.72	1	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	11.36	1	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	6.64	1	Yes	Yes	0	6	0	1
H:H:?1	R:R:R21	5.42	1	Yes	No	0	4	0	1
H:H:?2	R:R:R21	9.75	1	No	No	0	4	1	1
H:H:?1	H:H:?2	40.75	1	Yes	No	0	0	0	1
H:H:?2	H:H:?3	29.45	1	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	14.98
Average Nodes In Shell	12.00
Average Hubs In Shell	5.00
Average Links In Shell	18.00
Average Links Mediated by Hubs In Shell	15.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6PGS
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	7.31	1	Yes	No	7	6	2	2
R:R:T4	R:R:V20	11.11	1	No	Yes	6	6	2	2
H:H:?1	R:R:T4	5.26	1	Yes	No	0	6	1	2
R:R:G18	R:R:N15	3.39	1	No	Yes	3	7	2	2
R:R:N15	R:R:V20	10.35	1	Yes	Yes	7	6	2	2
H:H:?1	R:R:N15	25.72	1	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	1	2
H:H:?1	R:R:V20	6.64	1	Yes	Yes	0	6	1	2
H:H:?1	R:R:R21	5.42	1	Yes	No	0	4	1	1
H:H:?2	R:R:R21	9.75	1	No	No	0	4	0	1
H:H:?1	H:H:?2	40.75	1	Yes	No	0	0	1	0
H:H:?2	H:H:?3	29.45	1	No	No	0	0	0	1
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	26.65
Average Nodes In Shell	9.00
Average Hubs In Shell	3.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6PH7

Sensory

Opsins

Rhodopsin

Bos taurus

Nerol

Gt(CT)

2.9

2020-07-01

To be published

A 2D representation of the interactions of NAG in 6PH7
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	8.77	2	No	No	7	6	1	1
R:R:T4	R:R:V20	12.69	2	No	Yes	6	6	1	1
H:H:?1	R:R:T4	5.26	2	Yes	No	0	6	0	1
R:R:V11	R:R:V20	4.81	2	Yes	Yes	8	6	2	1
R:R:V11	R:R:Y30	5.05	2	Yes	Yes	8	4	2	2
R:R:N15	R:R:V20	10.35	2	No	Yes	7	6	1	1
H:H:?1	R:R:N15	29.4	2	Yes	No	0	7	0	1
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	11.36	2	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	5.32	2	Yes	Yes	0	6	0	1
H:H:?1	R:R:R21	4.33	2	Yes	No	0	4	0	1
H:H:?2	R:R:R21	8.67	2	No	No	0	4	1	1
H:H:?1	H:H:?2	31.94	2	Yes	No	0	0	0	1
H:H:?2	H:H:?3	33.3	2	No	No	0	0	1	2
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	13.72
Average Nodes In Shell	11.00
Average Hubs In Shell	4.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6PH7
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	8.77	2	No	No	7	6	2	2
R:R:T4	R:R:V20	12.69	2	No	Yes	6	6	2	2
H:H:?1	R:R:T4	5.26	2	Yes	No	0	6	1	2
R:R:N15	R:R:V20	10.35	2	No	Yes	7	6	2	2
H:H:?1	R:R:N15	29.4	2	Yes	No	0	7	1	2
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	1	2
H:H:?1	R:R:V20	5.32	2	Yes	Yes	0	6	1	2
H:H:?1	R:R:R21	4.33	2	Yes	No	0	4	1	1
H:H:?2	R:R:R21	8.67	2	No	No	0	4	0	1
H:H:?1	H:H:?2	31.94	2	Yes	No	0	0	1	0
H:H:?2	H:H:?3	33.3	2	No	No	0	0	0	1
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	24.64
Average Nodes In Shell	9.00
Average Hubs In Shell	2.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6QNO

Sensory

Opsins

Rhodopsin

Bos taurus

All-trans-retinal

Gi1/Beta1/Gamma1

4.38

2019-07-10

10.7554/eLife.46041

A 2D representation of the interactions of NAG in 6QNO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	7.31	11	Yes	Yes	7	6	1	1
R:R:T4	R:R:V20	7.93	11	Yes	Yes	6	6	1	1
H:H:?1	R:R:T4	3.94	11	Yes	Yes	0	6	0	1
R:R:F13	R:R:V20	3.93	0	No	Yes	4	6	2	1
R:R:G18	R:R:N15	3.39	0	No	Yes	3	7	2	1
R:R:N15	R:R:V20	7.39	11	Yes	Yes	7	6	1	1
H:H:?1	R:R:N15	25.72	11	Yes	Yes	0	7	0	1
R:R:V20	R:R:Y30	5.05	11	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	2.66	11	Yes	Yes	0	6	0	1
R:R:A26	R:R:R21	2.77	0	No	No	2	4	2	1
H:H:?1	R:R:R21	21.67	11	Yes	No	0	4	0	1
H:H:?1	H:H:?2	26.43	11	Yes	No	0	0	0	1
R:R:G3	R:R:T4	1.82	0	No	Yes	6	6	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	16.08
Average Nodes In Shell	11.00
Average Hubs In Shell	5.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6QNO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	7.31	11	Yes	Yes	7	6	2	2
R:R:T4	R:R:V20	7.93	11	Yes	Yes	6	6	2	2
H:H:?1	R:R:T4	3.94	11	Yes	Yes	0	6	1	2
R:R:N15	R:R:V20	7.39	11	Yes	Yes	7	6	2	2
H:H:?1	R:R:N15	25.72	11	Yes	Yes	0	7	1	2
H:H:?1	R:R:V20	2.66	11	Yes	Yes	0	6	1	2
H:H:?1	R:R:R21	21.67	11	Yes	No	0	4	1	2
H:H:?1	H:H:?2	26.43	11	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	26.43
Average Nodes In Shell	6.00
Average Hubs In Shell	4.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6UO8

Aminoacid

GABAB

GABAB1; GABAB2

Homo sapiens

SKF97541

GS39783

3.63

2020-06-10

10.1038/s41586-020-2408-4

A 2D representation of the interactions of NAG in 6UO8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D204	R:R:R202	2.38	No	No	4	5	1	2
R:R:D204	R:R:R203	2.38	No	No	4	3	1	2
H:H:?1	R:R:D204	9.68	Yes	No	0	4	0	1
H:H:?1	R:R:N482	25.72	Yes	No	0	8	0	1
H:H:?1	R:R:S485	2.68	Yes	No	0	4	0	1
H:H:?1	H:H:?2	34.14	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.05
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UO8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:D204	9.68	Yes	No	4	1	2
H:H:?1	R:R:N482	25.72	Yes	No	8	1	2
H:H:?1	R:R:S485	2.68	Yes	No	4	1	2
H:H:?1	H:H:?2	34.14	Yes	No	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	34.14
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UO8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N440	R:R:R436	4.82	13	No	No	7	1	1	1
R:R:R436	R:R:T442	5.17	13	No	Yes	1	8	1	2
H:H:?3	R:R:R436	8.67	13	No	No	0	1	0	1
H:H:?3	R:R:N440	29.4	13	No	No	0	7	0	1
H:H:?3	H:H:?4	30.84	13	No	No	0	0	0	1
H:H:?4	H:H:?5	37.14	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	22.97
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UO8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N440	R:R:R436	4.82	13	No	No	7	1	2	2
H:H:?3	R:R:R436	8.67	13	No	No	0	1	1	2
H:H:?3	R:R:N440	29.4	13	No	No	0	7	1	2
H:H:?3	H:H:?4	30.84	13	No	No	0	0	1	0
H:H:?4	H:H:?5	37.14	0	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	33.99
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UO8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:E405	S:S:R371	2.33	50	No	No	5	4	1	2
S:S:E405	S:S:N404	6.57	50	No	No	5	5	1	1
H:H:?6	S:S:N404	23.27	50	No	No	0	5	0	1
H:H:?6	S:S:E405	3.55	50	No	No	0	5	0	1
H:H:?6	H:H:?7	38.55	50	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	21.79
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UO8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:E405	S:S:N404	6.57	50	No	No	5	5	2	2
H:H:?6	S:S:N404	23.27	50	No	No	0	5	1	2
H:H:?6	S:S:E405	3.55	50	No	No	0	5	1	2
H:H:?6	H:H:?7	38.55	50	No	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	38.55
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UO8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:R277	R:R:Y510	4.12	0	No	No	7	5	2	1
R:R:D528	R:R:R277	9.53	36	No	No	6	7	1	2
R:R:F284	R:R:Y510	9.28	35	No	No	6	5	2	1
H:H:?8	R:R:Y510	2.09	36	No	No	0	5	0	1
R:R:D528	R:R:N514	9.42	36	No	No	6	4	1	1
H:H:?8	R:R:N514	25.72	36	No	No	0	4	0	1
H:H:?8	R:R:D528	3.63	36	No	No	0	6	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	10.48
Average Nodes In Shell	6.00
Average Hubs In Shell	0.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UO8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N502	R:R:T504	8.77	39	No	No	7	4	1	1
H:H:?9	R:R:N502	29.4	39	No	No	0	7	0	1
H:H:?9	R:R:T504	10.52	39	No	No	0	4	0	1
R:R:I505	R:R:T504	1.52	0	No	No	6	4	2	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	19.96
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UO8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:E296	S:S:T295	9.88	48	No	No	2	4	1	2
S:S:E296	S:S:N298	17.09	48	No	No	2	1	1	1
H:H:?10	S:S:E296	30.73	48	No	No	0	2	0	1
H:H:?10	S:S:N298	31.85	48	No	No	0	1	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	31.29
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UO8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?11	S:S:N453	26.95	0	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	26.95
Average Nodes In Shell	2.00
Average Hubs In Shell	0.00
Average Links In Shell	1.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UO8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:D387	S:S:D392	3.99	No	Yes	4	6	1	2
H:H:?12	S:S:D387	6.05	No	No	0	4	0	1
H:H:?12	S:S:N389	28.17	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	17.11
Average Nodes In Shell	4.00
Average Hubs In Shell	1.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UO8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?13	S:S:N90	34.3	0	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	34.30
Average Nodes In Shell	2.00
Average Hubs In Shell	0.00
Average Links In Shell	1.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6UO9

Aminoacid

GABAB

GABAB1; GABAB2

Homo sapiens

SKF97541

4.8

2020-06-10

10.1038/s41586-020-2408-4

A 2D representation of the interactions of NAG in 6UO9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:N409	29.4	0	No	No	0	3	0	1
H:H:?1	H:H:?2	44.05	0	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	36.72
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UO9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:N409	29.4	0	No	No	0	3	1	2
H:H:?1	H:H:?2	44.05	0	No	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	44.05
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UO9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:N514	28.17	44	No	No	4	0	1
H:H:?4	R:R:N514	2.45	44	No	No	4	1	1
H:H:?3	H:H:?4	49.56	44	No	No	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	38.87
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UO9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:N514	28.17	44	No	No	4	1	1
H:H:?4	R:R:N514	2.45	44	No	No	4	0	1
H:H:?3	H:H:?4	49.56	44	No	No	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	26.01
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UO9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N482	R:R:S485	2.98	43	No	No	8	4	1	1
H:H:?5	R:R:N482	26.95	43	No	No	0	8	0	1
H:H:?5	R:R:S485	5.36	43	No	No	0	4	0	1
H:H:?5	H:H:?6	31.94	43	No	No	0	0	0	1
R:R:I205	R:R:N482	1.42	0	No	No	6	8	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	21.42
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UO9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N482	R:R:S485	2.98	43	No	No	8	4	2	2
H:H:?5	R:R:N482	26.95	43	No	No	0	8	1	2
H:H:?5	R:R:S485	5.36	43	No	No	0	4	1	2
H:H:?5	H:H:?6	31.94	43	No	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	31.94
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UO9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?7	R:R:R436	4.33	No	No	0	1	0	1
H:H:?7	R:R:N440	31.85	No	No	0	7	0	1
H:H:?7	H:H:?8	34.14	No	No	0	0	0	1
H:H:?8	H:H:?9	33.3	No	No	0	0	1	2
R:R:N440	R:R:R202	1.21	No	No	7	5	1	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	23.44
Average Nodes In Shell	6.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UO9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?7	R:R:R436	4.33	No	No	1	1	2
H:H:?7	R:R:N440	31.85	No	No	7	1	2
H:H:?7	H:H:?8	34.14	No	No	0	1	0
H:H:?8	H:H:?9	33.3	No	No	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	33.72
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UO9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:E405	S:S:R371	12.79	0	No	No	5	4	1	2
S:S:N401	S:S:N404	2.72	54	No	No	4	5	1	1
H:H:?10	S:S:N401	9.8	54	Yes	No	0	4	0	1
H:H:?10	S:S:N404	29.4	54	Yes	No	0	5	0	1
H:H:?10	S:S:E405	2.36	54	Yes	No	0	5	0	1
H:H:?10	H:H:?11	49.56	54	Yes	No	0	0	0	1
S:S:L400	S:S:N401	1.37	0	No	No	3	4	2	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	22.78
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UO9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N401	S:S:N404	2.72	54	No	No	4	5	2	2
H:H:?10	S:S:N401	9.8	54	Yes	No	0	4	1	2
H:H:?10	S:S:N404	29.4	54	Yes	No	0	5	1	2
H:H:?10	S:S:E405	2.36	54	Yes	No	0	5	1	2
H:H:?10	H:H:?11	49.56	54	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	49.56
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UO9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N298	S:S:S300	4.47	No	No	1	3	1	2
H:H:?12	S:S:N298	31.85	No	No	0	1	0	1
H:H:?12	S:S:L303	1.23	No	No	0	6	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	16.54
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UO9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?13	S:S:N453	33.07	0	No	No	0	3	0	1
H:H:?13	S:S:D454	1.21	0	No	No	0	2	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	17.14
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6UOA

Aminoacid

GABAB

GABAB1; GABAB2

Homo sapiens

6.3

2020-06-10

10.1038/s41586-020-2408-4

A 2D representation of the interactions of NAG in 6UOA
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:N409	31.85	0	No	No	0	3	0	1
H:H:?1	H:H:?2	51.76	0	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	41.80
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UOA
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:N409	31.85	0	No	No	0	3	1	2
H:H:?1	H:H:?2	51.76	0	No	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	51.76
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UOA
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N440	R:R:R436	9.64	41	No	No	7	1	1	1
H:H:?3	R:R:R436	11.92	41	No	No	0	1	0	1
H:H:?3	R:R:N440	31.85	41	No	No	0	7	0	1
H:H:?3	H:H:?4	44.05	41	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	29.27
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UOA
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N440	R:R:R436	9.64	41	No	No	7	1	2	2
H:H:?3	R:R:R436	11.92	41	No	No	0	1	1	2
H:H:?3	R:R:N440	31.85	41	No	No	0	7	1	2
H:H:?3	H:H:?4	44.05	41	No	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	44.05
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UOA
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?5	R:R:D204	4.84	Yes	No	0	4	0	1
R:R:I205	R:R:N482	9.91	No	No	6	8	2	1
H:H:?5	R:R:N482	28.17	Yes	No	0	8	0	1
R:R:K483	R:R:S515	4.59	No	No	4	5	1	2
H:H:?5	R:R:K483	6.29	Yes	No	0	4	0	1
H:H:?5	H:H:?6	46.25	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	21.39
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UOA
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?5	R:R:D204	4.84	Yes	No	4	1	2
H:H:?5	R:R:N482	28.17	Yes	No	8	1	2
H:H:?5	R:R:K483	6.29	Yes	No	4	1	2
H:H:?5	H:H:?6	46.25	Yes	No	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	46.25
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UOA
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D528	R:R:N514	10.77	13	Yes	No	6	4	2	1
H:H:?7	R:R:N514	28.17	0	No	No	0	4	0	1
H:H:?7	H:H:?8	47.36	0	No	No	0	0	0	1
H:H:?7	R:R:R277	1.08	0	No	No	0	7	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	25.54
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UOA
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?7	R:R:N514	28.17	No	No	4	1	2
H:H:?7	H:H:?8	47.36	No	No	0	1	0
H:H:?7	R:R:R277	1.08	No	No	7	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	47.36
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UOA
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:F173	S:S:N404	3.62	15	Yes	No	7	5	2	1
S:S:E405	S:S:R371	11.63	0	No	No	5	4	1	2
H:H:?9	S:S:N401	3.67	0	Yes	No	0	4	0	1
H:H:?9	S:S:N404	33.07	0	Yes	No	0	5	0	1
H:H:?9	S:S:E405	2.36	0	Yes	No	0	5	0	1
H:H:?9	S:S:N419	9.8	0	Yes	No	0	5	0	1
H:H:?10	H:H:?9	41.85	0	No	Yes	0	0	1	0

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.15
Average Nodes In Shell	8.00
Average Hubs In Shell	2.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UOA
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?9	S:S:N401	3.67	Yes	No	4	1	2
H:H:?9	S:S:N404	33.07	Yes	No	5	1	2
H:H:?9	S:S:E405	2.36	Yes	No	5	1	2
H:H:?9	S:S:N419	9.8	Yes	No	5	1	2
H:H:?10	H:H:?9	41.85	No	Yes	0	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	41.85
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6UOA
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?11	S:S:N453	28.17	0	No	No	0	3	0	1
H:H:?11	S:S:D454	6.05	0	No	No	0	2	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	17.11
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6VJM

Aminoacid

GABAB

GABAB1; GABAB2

Homo sapiens

3.97

2020-06-10

10.1038/s41586-020-2408-4

A 2D representation of the interactions of NAG in 6VJM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N440	R:R:R436	7.23	6	No	Yes	7	1	1	1
R:R:R436	R:R:T442	2.59	6	Yes	No	1	8	1	2
R:R:E445	R:R:R436	6.98	6	No	Yes	5	1	2	1
H:H:?1	R:R:R436	13	6	Yes	Yes	0	1	0	1
H:H:?2	R:R:R436	2.17	6	No	Yes	0	1	1	1
H:H:?1	R:R:N440	35.52	6	Yes	No	0	7	0	1
R:R:E445	R:R:T442	12.7	6	No	No	5	8	2	2
H:H:?1	H:H:?2	46.25	6	Yes	No	0	0	0	1
H:H:?1	H:H:?3	34.44	6	Yes	No	0	0	0	1
H:H:?2	H:H:?3	10.6	6	No	No	0	0	1	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	32.30
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6VJM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N440	R:R:R436	7.23	6	No	Yes	7	1	2	1
R:R:R436	R:R:T442	2.59	6	Yes	No	1	8	1	2
R:R:E445	R:R:R436	6.98	6	No	Yes	5	1	2	1
H:H:?1	R:R:R436	13	6	Yes	Yes	0	1	1	1
H:H:?2	R:R:R436	2.17	6	No	Yes	0	1	0	1
H:H:?1	R:R:N440	35.52	6	Yes	No	0	7	1	2
R:R:E445	R:R:T442	12.7	6	No	No	5	8	2	2
H:H:?1	H:H:?2	46.25	6	Yes	No	0	0	1	0
H:H:?1	H:H:?3	34.44	6	Yes	No	0	0	1	1
H:H:?2	H:H:?3	10.6	6	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	19.67
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6VJM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D204	R:R:R202	2.38	No	No	4	5	1	2
H:H:?4	R:R:D204	20.58	Yes	No	0	4	0	1
R:R:N482	R:R:P207	6.52	No	No	8	3	1	2
H:H:?4	R:R:N482	25.72	Yes	No	0	8	0	1
R:R:R494	R:R:S485	3.95	No	No	4	4	2	1
H:H:?4	R:R:S485	4.02	Yes	No	0	4	0	1
H:H:?4	H:H:?5	36.34	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	21.66
Average Nodes In Shell	8.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6VJM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?4	R:R:D204	20.58	Yes	No	4	1	2
H:H:?4	R:R:N482	25.72	Yes	No	8	1	2
H:H:?4	R:R:S485	4.02	Yes	No	4	1	2
H:H:?4	H:H:?5	36.34	Yes	No	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	36.34
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6VJM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node2Shell
H:H:?6	R:R:N514	28.17	No	No	4	1
H:H:?6	H:H:?7	39.65	No	No	0	1
H:H:?6	R:R:A529	1.41	No	No	4	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	23.08
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6VJM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?6	R:R:N514	28.17	No	No	4	1	2
H:H:?6	H:H:?7	39.65	No	No	0	1	0
H:H:?6	R:R:A529	1.41	No	No	4	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	39.65
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6VJM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:E405	S:S:R371	9.3	No	No	5	4	1	2
H:H:?8	S:S:N401	3.67	Yes	No	0	4	0	1
H:H:?8	S:S:N404	29.4	Yes	No	0	5	0	1
H:H:?8	S:S:E405	4.73	Yes	No	0	5	0	1
H:H:?8	H:H:?9	33.04	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	17.71
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6VJM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?8	S:S:N401	3.67	Yes	No	4	1	2
H:H:?8	S:S:N404	29.4	Yes	No	5	1	2
H:H:?8	S:S:E405	4.73	Yes	No	5	1	2
H:H:?8	H:H:?9	33.04	Yes	No	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	33.04
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6VJM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K380	R:R:N409	2.8	0	No	No	6	3	2	1
H:H:?10	R:R:N409	25.72	0	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	25.72
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6VJM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:D454	S:S:N453	9.42	38	No	No	2	3	1	1
H:H:?11	S:S:N453	29.4	38	No	No	0	3	0	1
H:H:?11	S:S:D454	7.26	38	No	No	0	2	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.33
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6W2X

Aminoacid

GABAB

GABAB1; GABAB2

Homo sapiens

PubChem 5311042

PubChem 23727970

3.6

2020-07-01

10.1038/s41586-020-2469-4

A 2D representation of the interactions of NAG in 6W2X
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N440	R:R:R436	8.44	24	No	Yes	7	1	1	1
R:R:R436	R:R:T442	3.88	24	Yes	No	1	8	1	2
R:R:E445	R:R:R436	6.98	24	No	Yes	5	1	2	1
H:H:?1	R:R:R436	8.67	24	No	Yes	0	1	0	1
H:H:?1	R:R:N440	26.95	24	No	No	0	7	0	1
R:R:E445	R:R:T442	15.52	24	No	No	5	8	2	2
H:H:?1	H:H:?2	38.55	24	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	24.72
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6W2X
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N440	R:R:R436	8.44	24	No	Yes	7	1	2	2
H:H:?1	R:R:R436	8.67	24	No	Yes	0	1	1	2
H:H:?1	R:R:N440	26.95	24	No	No	0	7	1	2
H:H:?1	H:H:?2	38.55	24	No	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	38.55
Average Nodes In Shell	4.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	2.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6W2X
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	S:S:N404	29.4	Yes	No	0	5	0	1
S:S:M423	S:S:R418	4.96	No	No	5	4	2	1
H:H:?3	S:S:R418	18.42	Yes	No	0	4	0	1
H:H:?3	H:H:?4	40.75	Yes	No	0	0	0	1
H:H:?3	S:S:E405	1.18	Yes	No	0	5	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	22.44
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6W2X
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?3	S:S:N404	29.4	Yes	No	5	1	2
H:H:?3	S:S:R418	18.42	Yes	No	4	1	2
H:H:?3	H:H:?4	40.75	Yes	No	0	1	0
H:H:?3	S:S:E405	1.18	Yes	No	5	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	40.75
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6W2X
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:R277	R:R:Y510	4.12	No	Yes	7	5	2	1
R:R:F284	R:R:Y510	3.09	No	Yes	6	5	2	1
R:R:R511	R:R:Y510	2.06	No	Yes	4	5	2	1
H:H:?5	R:R:Y510	8.37	No	Yes	0	5	0	1
H:H:?5	R:R:N514	26.95	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	17.66
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6W2X
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I205	R:R:W475	3.52	38	Yes	No	6	8	2	2
R:R:I205	R:R:N482	2.83	38	Yes	No	6	8	2	1
R:R:L479	R:R:W475	2.28	0	No	No	7	8	1	2
H:H:?6	R:R:L479	2.47	0	No	No	0	7	0	1
H:H:?6	R:R:N482	25.72	0	No	No	0	8	0	1
R:R:N482	R:R:S485	1.49	0	No	No	8	4	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.09
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	2.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6W2Y

Aminoacid

GABAB

GABAB1; GABAB1

Homo sapiens

PubChem 5311042

PubChem 23727970

3.2

2020-07-01

10.1038/s41586-020-2469-4

A 2D representation of the interactions of NAG in 6W2Y
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N440	R:R:R436	7.23	28	No	No	7	1	1	1
R:R:R436	R:R:T442	3.88	28	No	No	1	8	1	2
H:H:?1	R:R:R436	15.17	28	No	No	0	1	0	1
H:H:?1	R:R:N440	35.52	28	No	No	0	7	0	1
H:H:?1	H:H:?2	31.94	28	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	27.54
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6W2Y
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N440	R:R:R436	7.23	28	No	No	7	1	2	2
H:H:?1	R:R:R436	15.17	28	No	No	0	1	1	2
H:H:?1	R:R:N440	35.52	28	No	No	0	7	1	2
H:H:?1	H:H:?2	31.94	28	No	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	31.94
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6W2Y
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N440	S:S:R436	10.85	35	No	No	7	1	1	1
H:H:?3	S:S:R436	17.34	35	No	No	0	1	0	1
H:H:?3	S:S:N440	28.17	35	No	No	0	7	0	1
H:H:?3	H:H:?4	37.44	35	No	No	0	0	0	1
S:S:R436	S:S:T442	2.59	35	No	No	1	8	1	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	27.65
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6W2Y
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N440	S:S:R436	10.85	35	No	No	7	1	2	2
H:H:?3	S:S:R436	17.34	35	No	No	0	1	1	2
H:H:?3	S:S:N440	28.17	35	No	No	0	7	1	2
H:H:?3	H:H:?4	37.44	35	No	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	37.44
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6W2Y
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I205	R:R:V199	3.07	7	Yes	No	6	7	1	2
R:R:D204	R:R:R202	9.53	7	No	No	4	5	2	2
R:R:I205	R:R:R202	3.76	7	Yes	No	6	5	1	2
R:R:R202	R:R:W475	5	7	No	Yes	5	8	2	2
R:R:D204	R:R:I205	5.6	7	No	Yes	4	6	2	1
R:R:I205	R:R:L206	4.28	7	Yes	Yes	6	9	1	2
R:R:I205	R:R:W475	4.7	7	Yes	Yes	6	8	1	2
H:H:?5	R:R:N482	24.5	0	No	No	0	8	0	1
R:R:N482	R:R:S485	2.98	0	No	No	8	4	1	2
H:H:?5	R:R:I205	2.55	0	No	Yes	0	6	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	13.53
Average Nodes In Shell	9.00
Average Hubs In Shell	3.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6W2Y
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:R277	S:S:Y510	7.2	No	No	7	5	2	1
S:S:F284	S:S:Y510	8.25	Yes	No	6	5	2	1
H:H:?6	S:S:Y510	10.46	No	No	0	5	0	1
H:H:?6	S:S:N514	25.72	No	No	0	4	0	1
H:H:?6	S:S:A529	2.81	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.00
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6WIV

Aminoacid

GABAB

GABAB1; GABAB2

Homo sapiens

PubChem 52923113; PubChem 52924645

3.3

2020-07-01

10.1038/s41586-020-2452-0

A 2D representation of the interactions of NAG in 6WIV
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I205	R:R:L206	2.85	4	Yes	Yes	6	9	2	2
R:R:I205	R:R:N482	2.83	4	Yes	No	6	8	2	1
R:R:L206	R:R:N482	4.12	4	Yes	No	9	8	2	1
H:H:?1	R:R:N482	25.72	0	No	No	0	8	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	25.72
Average Nodes In Shell	4.00
Average Hubs In Shell	2.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	3.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6WIV
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F498	R:R:I505	6.28	0	Yes	Yes	8	6	2	1
R:R:N502	R:R:T504	13.16	23	No	No	7	4	1	2
R:R:I505	R:R:N502	4.25	23	Yes	No	6	7	1	1
H:H:?2	R:R:N502	24.5	23	No	No	0	7	0	1
R:R:I505	R:R:T504	3.04	23	Yes	No	6	4	1	2
H:H:?2	R:R:I505	3.82	23	No	Yes	0	6	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	14.16
Average Nodes In Shell	5.00
Average Hubs In Shell	2.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6WIV
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:N514	26.95	0	No	No	0	4	0	1
R:R:F284	R:R:N514	2.42	4	Yes	No	6	4	2	1
H:H:?3	R:R:A529	1.41	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.18
Average Nodes In Shell	4.00
Average Hubs In Shell	1.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 6WIV
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:F173	S:S:N404	3.62	6	Yes	No	7	5	2	1
H:H:?4	S:S:N404	26.95	0	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	26.95
Average Nodes In Shell	3.00
Average Hubs In Shell	1.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7AD3

Ste2-like

STE2

Saccharomyces cerevisiae

Alpha-factor mating pheromone

Gi1/STE4/Gamma2

3.3

2020-12-09

10.1038/s41586-020-2994-1

A 2D representation of the interactions of NAG in 7AD3
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:T23	S:S:T35	3.14	0	No	No	5	4	1	2
H:H:?1	S:S:N25	25.72	16	Yes	No	0	7	0	1
H:H:?2	S:S:N25	4.9	16	Yes	No	0	7	1	1
H:H:?1	R:R:N25	9.8	16	Yes	No	0	7	0	1
H:H:?2	R:R:N25	28.17	16	Yes	No	0	7	1	1
H:H:?1	H:H:?2	12.11	16	Yes	Yes	0	0	0	1
H:H:?1	S:S:T23	2.63	16	Yes	No	0	5	0	1
R:R:N25	R:R:T35	1.46	16	No	No	7	4	1	2
H:H:?2	S:S:T27	1.31	16	Yes	No	0	5	1	2
H:H:?2	S:S:N32	1.22	16	Yes	No	0	5	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	12.56
Average Nodes In Shell	9.00
Average Hubs In Shell	2.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7AD3
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	S:S:N25	25.72	16	Yes	No	0	7	1	1
H:H:?2	S:S:N25	4.9	16	Yes	No	0	7	0	1
R:R:S22	S:S:T27	3.2	0	No	No	9	5	2	1
H:H:?1	R:R:N25	9.8	16	Yes	No	0	7	1	1
H:H:?2	R:R:N25	28.17	16	Yes	No	0	7	0	1
H:H:?1	H:H:?2	12.11	16	Yes	Yes	0	0	1	0
H:H:?1	S:S:T23	2.63	16	Yes	No	0	5	1	2
R:R:N25	R:R:T35	1.46	16	No	No	7	4	1	2
H:H:?2	S:S:T27	1.31	16	Yes	No	0	5	0	1
H:H:?2	S:S:N32	1.22	16	Yes	No	0	5	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	9.54
Average Nodes In Shell	9.00
Average Hubs In Shell	2.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7C7Q

Aminoacid

GABAB

GABAB1; GABAB2

Homo sapiens

Baclofen

PubChem 7023848

2020-07-01

10.1038/s41422-020-0350-5

A 2D representation of the interactions of NAG in 7C7Q
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:N409	25.72	0	No	No	0	3	0	1
R:R:C376	R:R:N409	1.57	1	Yes	No	9	3	2	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	25.72
Average Nodes In Shell	3.00
Average Hubs In Shell	1.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7C7Q
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N440	R:R:R436	8.44	29	No	No	7	1	1	1
R:R:E445	R:R:R436	8.14	0	No	No	5	1	2	1
H:H:?2	R:R:R436	6.5	29	No	No	0	1	0	1
H:H:?2	R:R:N440	29.4	29	No	No	0	7	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	17.95
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7C7Q
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I205	R:R:V199	3.07	15	Yes	No	6	7	1	2
R:R:D204	R:R:R202	13.1	15	No	No	4	5	1	2
R:R:I205	R:R:R202	3.76	15	Yes	No	6	5	1	2
R:R:D204	R:R:I205	4.2	15	No	Yes	4	6	1	1
H:H:?3	R:R:D204	7.26	15	No	No	0	4	0	1
R:R:I205	R:R:L206	2.85	15	Yes	No	6	9	1	2
H:H:?3	R:R:I205	3.82	15	No	Yes	0	6	0	1
R:R:L206	R:R:N482	2.75	0	No	No	9	8	2	1
H:H:?3	R:R:N482	24.5	15	No	No	0	8	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	11.86
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7C7Q
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D497	R:R:R494	8.34	0	No	No	4	4	1	2
R:R:D497	R:R:I505	2.8	0	No	Yes	4	6	1	2
H:H:?4	R:R:D497	13.32	30	No	No	0	4	0	1
R:R:N499	R:R:N502	4.09	0	No	No	5	7	2	1
R:R:N502	R:R:T504	8.77	30	No	No	7	4	1	1
H:H:?4	R:R:N502	37.97	30	No	No	0	7	0	1
R:R:I505	R:R:T504	3.04	0	Yes	No	6	4	2	1
H:H:?4	R:R:T504	9.2	30	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	20.16
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	2.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7C7Q
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I263	R:R:Y510	3.63	0	Yes	Yes	6	5	2	1
R:R:R277	R:R:Y510	5.14	0	No	Yes	7	5	2	1
R:R:F284	R:R:Y510	8.25	28	No	Yes	6	5	2	1
H:H:?5	R:R:Y510	7.32	0	No	Yes	0	5	0	1
H:H:?5	R:R:N514	20.82	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	14.07
Average Nodes In Shell	6.00
Average Hubs In Shell	2.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7C7Q
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?6	S:S:N389	29.4	0	No	No	0	5	0	1
S:S:N389	S:S:T391	1.46	0	No	No	5	4	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	29.40
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7C7Q
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N401	S:S:R397	6.03	No	No	4	3	1	2
H:H:?7	S:S:N404	34.3	No	No	0	5	0	1
H:H:?7	S:S:N401	1.22	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	17.76
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7C7Q
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?8	S:S:N453	26.95	0	No	No	0	3	0	1
S:S:D454	S:S:N453	1.35	0	No	No	2	3	2	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	26.95
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7C7S

Aminoacid

GABAB

GABAB1; GABAB2

Homo sapiens

CGP54626

2.9

2020-07-01

10.1038/s41422-020-0350-5

A 2D representation of the interactions of NAG in 7C7S
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K380	R:R:N409	2.8	0	No	No	6	3	2	1
H:H:?1	R:R:N409	29.4	0	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	29.40
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7C7S
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N440	R:R:R436	4.82	4	No	Yes	7	1	1	1
R:R:R436	R:R:T442	6.47	4	Yes	No	1	8	1	2
R:R:E445	R:R:R436	8.14	4	Yes	Yes	5	1	2	1
H:H:?2	R:R:R436	3.25	4	No	Yes	0	1	0	1
H:H:?2	R:R:N440	34.3	4	No	No	0	7	0	1
R:R:E445	R:R:T442	11.29	4	Yes	No	5	8	2	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	18.77
Average Nodes In Shell	5.00
Average Hubs In Shell	2.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7C7S
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D204	R:R:R202	3.57	0	No	No	4	5	1	2
R:R:R202	R:R:W475	4	0	No	Yes	5	8	2	2
H:H:?3	R:R:D204	10.9	4	Yes	No	0	4	0	1
R:R:I205	R:R:L206	4.28	4	Yes	Yes	6	9	1	2
R:R:I205	R:R:W475	3.52	4	Yes	Yes	6	8	1	2
R:R:I205	R:R:L479	2.85	4	Yes	Yes	6	7	1	1
R:R:I205	R:R:N482	9.91	4	Yes	No	6	8	1	1
H:H:?3	R:R:I205	6.37	4	Yes	Yes	0	6	0	1
R:R:L206	R:R:N482	2.75	4	Yes	No	9	8	2	1
R:R:L479	R:R:W475	3.42	4	Yes	Yes	7	8	1	2
R:R:F518	R:R:L479	7.31	0	Yes	Yes	9	7	2	1
H:H:?3	R:R:L479	3.7	4	Yes	Yes	0	7	0	1
H:H:?3	R:R:N482	24.5	4	Yes	No	0	8	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	11.37
Average Nodes In Shell	9.00
Average Hubs In Shell	6.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7C7S
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I505	R:R:V493	6.14	32	Yes	No	6	3	1	2
R:R:D497	R:R:R494	7.15	0	No	No	4	4	1	2
H:H:?4	R:R:D497	7.26	32	Yes	No	0	4	0	1
R:R:N499	R:R:N502	13.62	0	No	No	5	7	2	1
H:H:?4	R:R:N502	26.95	32	Yes	No	0	7	0	1
R:R:I505	R:R:T504	3.04	32	Yes	No	6	4	1	1
H:H:?4	R:R:T504	3.94	32	Yes	No	0	4	0	1
R:R:I505	R:R:I509	2.94	32	Yes	No	6	6	1	2
H:H:?4	R:R:I505	8.91	32	Yes	Yes	0	6	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	11.77
Average Nodes In Shell	9.00
Average Hubs In Shell	2.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7C7S
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?5	R:R:N514	24.5	0	No	No	0	4	0	1
H:H:?5	R:R:S515	2.68	0	No	No	0	5	0	1
R:R:F284	R:R:N514	1.21	30	Yes	No	6	4	2	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.59
Average Nodes In Shell	4.00
Average Hubs In Shell	1.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7C7S
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?6	S:S:D387	14.53	41	No	No	0	4	0	1
S:S:N389	S:S:T391	8.77	41	No	No	5	4	1	1
H:H:?6	S:S:N389	25.72	41	No	No	0	5	0	1
H:H:?6	S:S:T391	7.89	41	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	16.05
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7C7S
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?7	S:S:N404	23.27	0	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	23.27
Average Nodes In Shell	2.00
Average Hubs In Shell	0.00
Average Links In Shell	1.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7C7S
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?8	S:S:N453	24.5	0	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	24.50
Average Nodes In Shell	2.00
Average Hubs In Shell	0.00
Average Links In Shell	1.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7DD5

Ion

Calcium-sensing

CaS

Gallus gallus

Ca; Ca; Tryptophan; NPS-2143

3.2

2021-06-16

10.1126/sciadv.abg1483

A 2D representation of the interactions of NAG in 7DD5
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H510	R:R:K324	9.17	18	No	No	5	5	1	2
R:R:V486	R:R:Y514	8.83	0	No	Yes	5	5	2	1
R:R:H510	R:R:N488	6.38	18	No	Yes	5	8	1	1
R:R:N488	R:R:N512	13.62	18	Yes	Yes	8	3	1	1
R:R:N488	R:R:V513	5.91	18	Yes	No	8	3	1	2
R:R:N488	R:R:Y514	8.14	18	Yes	Yes	8	5	1	1
H:H:?1	R:R:N488	23.27	18	Yes	Yes	0	8	0	1
H:H:?1	R:R:H510	13.76	18	Yes	No	0	5	0	1
R:R:N512	R:R:Y514	4.65	18	Yes	Yes	3	5	1	1
R:R:A515	R:R:N512	3.13	0	No	Yes	2	3	2	1
H:H:?1	R:R:N512	20.82	18	Yes	Yes	0	3	0	1
H:H:?2	R:R:N512	3.67	18	No	Yes	0	3	1	1
H:H:?1	R:R:Y514	13.59	18	Yes	Yes	0	5	0	1
H:H:?1	H:H:?2	26.43	18	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	19.57
Average Nodes In Shell	10.00
Average Hubs In Shell	4.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	13.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD5
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H510	R:R:N488	6.38	18	No	Yes	5	8	2	2
R:R:N488	R:R:N512	13.62	18	Yes	Yes	8	3	2	1
R:R:N488	R:R:Y514	8.14	18	Yes	Yes	8	5	2	2
H:H:?1	R:R:N488	23.27	18	Yes	Yes	0	8	1	2
H:H:?1	R:R:H510	13.76	18	Yes	No	0	5	1	2
R:R:N512	R:R:Y514	4.65	18	Yes	Yes	3	5	1	2
R:R:A515	R:R:N512	3.13	0	No	Yes	2	3	2	1
H:H:?1	R:R:N512	20.82	18	Yes	Yes	0	3	1	1
H:H:?2	R:R:N512	3.67	18	No	Yes	0	3	0	1
H:H:?1	R:R:Y514	13.59	18	Yes	Yes	0	5	1	2
H:H:?1	H:H:?2	26.43	18	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	15.05
Average Nodes In Shell	7.00
Average Hubs In Shell	4.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD5
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R206	4.33	16	Yes	No	0	9	0	1
H:H:?4	R:R:R206	5.42	16	No	No	0	9	1	1
R:R:N208	R:R:N541	12.26	16	No	No	9	9	1	1
R:R:C561	R:R:N208	7.87	0	No	No	9	9	2	1
H:H:?3	R:R:N208	11.02	16	Yes	No	0	9	0	1
R:R:F539	R:R:N541	6.04	16	No	No	9	9	1	1
R:R:F539	R:R:R544	18.17	16	No	No	9	6	1	2
H:H:?3	R:R:F539	4.35	16	Yes	No	0	9	0	1
H:H:?3	R:R:N541	25.72	16	Yes	No	0	9	0	1
R:R:D545	R:R:T577	2.89	0	No	No	9	7	1	2
R:R:D545	R:R:D578	13.31	0	No	No	9	7	1	2
H:H:?3	R:R:D545	3.63	16	Yes	No	0	9	0	1
H:H:?3	H:H:?4	35.24	16	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.05
Average Nodes In Shell	11.00
Average Hubs In Shell	1.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD5
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R206	4.33	16	Yes	No	0	9	1	1
H:H:?4	R:R:R206	5.42	16	No	No	0	9	0	1
R:R:N208	R:R:N541	12.26	16	No	No	9	9	2	2
H:H:?3	R:R:N208	11.02	16	Yes	No	0	9	1	2
R:R:F539	R:R:N541	6.04	16	No	No	9	9	2	2
H:H:?3	R:R:F539	4.35	16	Yes	No	0	9	1	2
H:H:?3	R:R:N541	25.72	16	Yes	No	0	9	1	2
H:H:?3	R:R:D545	3.63	16	Yes	No	0	9	1	2
H:H:?3	H:H:?4	35.24	16	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	20.33
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD5
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:K324	S:S:N488	6.99	14	No	Yes	5	8	1	1
H:H:?5	S:S:K324	13.84	14	Yes	No	0	5	0	1
S:S:V486	S:S:Y514	3.79	0	No	No	5	5	2	1
S:S:H510	S:S:N488	6.38	14	No	Yes	5	8	1	1
S:S:N488	S:S:N512	2.72	14	Yes	Yes	8	3	1	1
H:H:?5	S:S:N488	26.95	14	Yes	Yes	0	8	0	1
H:H:?5	S:S:H510	11.47	14	Yes	No	0	5	0	1
S:S:N512	S:S:Y514	4.65	14	Yes	No	3	5	1	1
S:S:A515	S:S:N512	4.69	0	No	Yes	2	3	2	1
H:H:?5	S:S:N512	19.6	14	Yes	Yes	0	3	0	1
H:H:?6	S:S:N512	3.67	14	No	Yes	0	3	1	1
H:H:?5	S:S:Y514	12.55	14	Yes	No	0	5	0	1
H:H:?5	H:H:?6	34.14	14	Yes	No	0	0	0	1
S:S:F522	S:S:H510	1.13	0	No	No	6	5	2	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	19.76
Average Nodes In Shell	10.00
Average Hubs In Shell	3.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD5
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:K324	S:S:N488	6.99	14	No	Yes	5	8	2	2
H:H:?5	S:S:K324	13.84	14	Yes	No	0	5	1	2
S:S:H510	S:S:N488	6.38	14	No	Yes	5	8	2	2
S:S:N488	S:S:N512	2.72	14	Yes	Yes	8	3	2	1
H:H:?5	S:S:N488	26.95	14	Yes	Yes	0	8	1	2
H:H:?5	S:S:H510	11.47	14	Yes	No	0	5	1	2
S:S:N512	S:S:Y514	4.65	14	Yes	No	3	5	1	2
S:S:A515	S:S:N512	4.69	0	No	Yes	2	3	2	1
H:H:?5	S:S:N512	19.6	14	Yes	Yes	0	3	1	1
H:H:?6	S:S:N512	3.67	14	No	Yes	0	3	0	1
H:H:?5	S:S:Y514	12.55	14	Yes	No	0	5	1	2
H:H:?5	H:H:?6	34.14	14	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	18.91
Average Nodes In Shell	8.00
Average Hubs In Shell	3.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD5
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?7	S:S:R206	5.42	10	Yes	No	0	9	0	1
H:H:?8	S:S:R206	15.17	10	No	No	0	9	1	1
S:S:N208	S:S:N541	13.62	10	No	No	9	9	1	1
S:S:C561	S:S:N208	4.72	10	No	No	9	9	2	1
H:H:?7	S:S:N208	7.35	10	Yes	No	0	9	0	1
S:S:F539	S:S:N541	7.25	10	No	No	9	9	1	1
S:S:F539	S:S:R544	3.21	10	No	No	9	6	1	2
H:H:?7	S:S:F539	4.35	10	Yes	No	0	9	0	1
H:H:?7	S:S:N541	23.27	10	Yes	No	0	9	0	1
S:S:D545	S:S:D578	5.32	0	No	No	9	7	1	2
H:H:?7	S:S:D545	6.05	10	Yes	No	0	9	0	1
H:H:?7	H:H:?8	37.44	10	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.98
Average Nodes In Shell	10.00
Average Hubs In Shell	1.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD5
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?7	S:S:R206	5.42	10	Yes	No	0	9	1	1
H:H:?8	S:S:R206	15.17	10	No	No	0	9	0	1
S:S:N208	S:S:N541	13.62	10	No	No	9	9	2	2
H:H:?7	S:S:N208	7.35	10	Yes	No	0	9	1	2
S:S:F539	S:S:N541	7.25	10	No	No	9	9	2	2
H:H:?7	S:S:F539	4.35	10	Yes	No	0	9	1	2
H:H:?7	S:S:N541	23.27	10	Yes	No	0	9	1	2
H:H:?7	S:S:D545	6.05	10	Yes	No	0	9	1	2
H:H:?7	H:H:?8	37.44	10	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	26.30
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD5
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N288	R:R:T290	2.92	30	No	No	4	4	1	1
H:H:?9	R:R:N288	28.17	30	No	No	0	4	0	1
H:H:?9	R:R:T290	3.94	30	No	No	0	4	0	1
R:R:G291	R:R:T290	1.82	0	No	No	6	4	2	1
R:R:N288	R:R:V314	1.48	30	No	No	4	6	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	16.05
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD5
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N400	R:R:T402	14.62	32	No	No	7	2	1	1
H:H:?10	R:R:N400	37.97	32	No	No	0	7	0	1
H:H:?10	R:R:T402	10.52	32	No	No	0	2	0	1
H:H:?10	R:R:S403	5.36	32	No	No	0	4	0	1
R:R:S403	R:R:V404	1.62	0	No	Yes	4	3	1	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	17.95
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD5
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D478	R:R:N468	5.39	No	No	8	8	2	1
H:H:?11	R:R:N468	29.4	No	No	0	8	0	1
R:R:E475	R:R:Q476	2.55	No	No	3	6	2	1
R:R:Q476	R:R:T470	1.42	No	No	6	6	1	2
H:H:?11	R:R:Q476	1.19	No	No	0	6	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.29
Average Nodes In Shell	6.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD5
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N288	S:S:T290	4.39	50	No	No	4	4	1	1
H:H:?12	S:S:N288	30.62	50	No	No	0	4	0	1
H:H:?12	S:S:T290	3.94	50	No	No	0	4	0	1
S:S:T290	S:S:V314	1.59	50	No	No	4	6	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	17.28
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD5
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N400	S:S:T402	8.77	52	No	No	7	2	1	1
S:S:N400	S:S:S403	2.98	52	No	No	7	4	1	2
H:H:?13	S:S:N400	28.17	52	No	No	0	7	0	1
H:H:?13	S:S:T402	15.78	52	No	No	0	2	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	21.98
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD5
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N468	S:S:Q476	6.6	55	No	No	8	6	1	1
S:S:D478	S:S:N468	9.42	0	No	No	8	8	2	1
H:H:?14	S:S:N468	29.4	55	No	No	0	8	0	1
S:S:Q476	S:S:T470	5.67	55	No	No	6	6	1	2
H:H:?14	S:S:Q476	13.06	55	No	No	0	6	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	21.23
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7DD6

Ion

Calcium-sensing

CaS

Gallus gallus

Ca; Ca; Tryptophan

3.2

2021-06-16

10.1126/sciadv.abg1483

A 2D representation of the interactions of NAG in 7DD6
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H510	R:R:K324	7.86	3	Yes	No	6	5	1	2
R:R:H510	R:R:N488	3.83	3	Yes	Yes	6	8	1	1
R:R:N488	R:R:N512	12.26	3	Yes	Yes	8	3	1	1
R:R:N488	R:R:V513	4.43	3	Yes	Yes	8	3	1	2
R:R:N488	R:R:Y514	8.14	3	Yes	Yes	8	5	1	1
H:H:?1	R:R:N488	24.5	3	Yes	Yes	0	8	0	1
R:R:H510	R:R:N512	2.55	3	Yes	Yes	6	3	1	1
H:H:?1	R:R:H510	13.76	3	Yes	Yes	0	6	0	1
R:R:N512	R:R:Y514	8.14	3	Yes	Yes	3	5	1	1
H:H:?1	R:R:N512	17.15	3	Yes	Yes	0	3	0	1
H:H:?1	R:R:Y514	13.59	3	Yes	Yes	0	5	0	1
H:H:?1	H:H:?2	30.84	3	Yes	No	0	0	0	1
R:R:A515	R:R:N512	1.56	0	No	Yes	3	3	2	1
R:R:V486	R:R:Y514	1.26	0	No	Yes	6	5	2	1
R:R:F522	R:R:H510	1.13	0	No	Yes	7	6	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	19.97
Average Nodes In Shell	11.00
Average Hubs In Shell	6.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	15.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD6
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H510	R:R:N488	3.83	3	Yes	Yes	6	8	2	2
R:R:N488	R:R:N512	12.26	3	Yes	Yes	8	3	2	2
R:R:N488	R:R:Y514	8.14	3	Yes	Yes	8	5	2	2
H:H:?1	R:R:N488	24.5	3	Yes	Yes	0	8	1	2
R:R:H510	R:R:N512	2.55	3	Yes	Yes	6	3	2	2
H:H:?1	R:R:H510	13.76	3	Yes	Yes	0	6	1	2
R:R:N512	R:R:Y514	8.14	3	Yes	Yes	3	5	2	2
H:H:?1	R:R:N512	17.15	3	Yes	Yes	0	3	1	2
H:H:?1	R:R:Y514	13.59	3	Yes	Yes	0	5	1	2
H:H:?1	H:H:?2	30.84	3	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	30.84
Average Nodes In Shell	6.00
Average Hubs In Shell	5.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD6
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R206	8.67	8	Yes	No	0	9	0	1
H:H:?4	R:R:R206	10.84	8	No	No	0	9	1	1
R:R:N208	R:R:N541	12.26	8	No	No	9	9	1	1
R:R:C561	R:R:N208	4.72	8	No	No	9	9	2	1
H:H:?3	R:R:N208	11.02	8	Yes	No	0	9	0	1
R:R:F539	R:R:N541	6.04	8	No	No	9	9	1	1
R:R:F539	R:R:R544	18.17	8	No	No	9	5	1	2
H:H:?3	R:R:F539	4.35	8	Yes	No	0	9	0	1
H:H:?3	R:R:N541	25.72	8	Yes	No	0	9	0	1
H:H:?3	H:H:?4	33.04	8	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	16.56
Average Nodes In Shell	8.00
Average Hubs In Shell	1.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD6
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R206	8.67	8	Yes	No	0	9	1	1
H:H:?4	R:R:R206	10.84	8	No	No	0	9	0	1
R:R:N208	R:R:N541	12.26	8	No	No	9	9	2	2
H:H:?3	R:R:N208	11.02	8	Yes	No	0	9	1	2
R:R:F539	R:R:N541	6.04	8	No	No	9	9	2	2
H:H:?3	R:R:F539	4.35	8	Yes	No	0	9	1	2
H:H:?3	R:R:N541	25.72	8	Yes	No	0	9	1	2
H:H:?3	H:H:?4	33.04	8	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	21.94
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD6
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:K324	S:S:N488	2.8	17	No	Yes	5	8	2	1
S:S:H510	S:S:K324	6.55	17	Yes	No	5	5	1	2
S:S:V486	S:S:Y514	3.79	0	No	No	5	5	2	1
S:S:H510	S:S:N488	8.93	17	Yes	Yes	5	8	1	1
S:S:N488	S:S:N512	6.81	17	Yes	Yes	8	3	1	1
H:H:?5	S:S:N488	26.95	17	Yes	Yes	0	8	0	1
S:S:H510	S:S:N512	2.55	17	Yes	Yes	5	3	1	1
H:H:?5	S:S:H510	12.62	17	Yes	Yes	0	5	0	1
S:S:N512	S:S:Y514	5.81	17	Yes	No	3	5	1	1
H:H:?5	S:S:N512	19.6	17	Yes	Yes	0	3	0	1
H:H:?5	S:S:Y514	11.5	17	Yes	No	0	5	0	1
H:H:?5	H:H:?6	29.74	17	Yes	No	0	0	0	1
S:S:F522	S:S:H510	1.13	0	No	Yes	6	5	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	20.08
Average Nodes In Shell	9.00
Average Hubs In Shell	4.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD6
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:H510	S:S:N488	8.93	17	Yes	Yes	5	8	2	2
S:S:N488	S:S:N512	6.81	17	Yes	Yes	8	3	2	2
H:H:?5	S:S:N488	26.95	17	Yes	Yes	0	8	1	2
S:S:H510	S:S:N512	2.55	17	Yes	Yes	5	3	2	2
H:H:?5	S:S:H510	12.62	17	Yes	Yes	0	5	1	2
S:S:N512	S:S:Y514	5.81	17	Yes	No	3	5	2	2
H:H:?5	S:S:N512	19.6	17	Yes	Yes	0	3	1	2
H:H:?5	S:S:Y514	11.5	17	Yes	No	0	5	1	2
H:H:?5	H:H:?6	29.74	17	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	29.74
Average Nodes In Shell	6.00
Average Hubs In Shell	4.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD6
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?7	S:S:R206	4.33	6	Yes	No	0	9	0	1
H:H:?8	S:S:R206	15.17	6	No	No	0	9	1	1
S:S:N208	S:S:N541	12.26	6	No	No	9	9	1	1
S:S:C561	S:S:N208	4.72	6	Yes	No	9	9	2	1
H:H:?7	S:S:N208	7.35	6	Yes	No	0	9	0	1
S:S:F539	S:S:N541	8.46	6	No	No	9	9	1	1
S:S:F539	S:S:R544	14.97	6	No	No	9	6	1	2
H:H:?7	S:S:F539	5.43	6	Yes	No	0	9	0	1
H:H:?7	S:S:N541	25.72	6	Yes	No	0	9	0	1
S:S:D545	S:S:D578	13.31	0	No	Yes	9	7	1	2
H:H:?7	S:S:D545	6.05	6	Yes	No	0	9	0	1
H:H:?7	H:H:?8	39.65	6	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.76
Average Nodes In Shell	10.00
Average Hubs In Shell	3.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD6
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?7	S:S:R206	4.33	6	Yes	No	0	9	1	1
H:H:?8	S:S:R206	15.17	6	No	No	0	9	0	1
S:S:N208	S:S:N541	12.26	6	No	No	9	9	2	2
H:H:?7	S:S:N208	7.35	6	Yes	No	0	9	1	2
S:S:F539	S:S:N541	8.46	6	No	No	9	9	2	2
H:H:?7	S:S:F539	5.43	6	Yes	No	0	9	1	2
H:H:?7	S:S:N541	25.72	6	Yes	No	0	9	1	2
H:H:?7	S:S:D545	6.05	6	Yes	No	0	9	1	2
H:H:?7	H:H:?8	39.65	6	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	27.41
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD6
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N288	R:R:T290	4.39	32	No	No	3	4	1	1
H:H:?9	R:R:N288	30.62	32	No	No	0	3	0	1
H:H:?9	R:R:T290	6.57	32	No	No	0	4	0	1
R:R:G291	R:R:T290	1.82	0	No	No	6	4	2	1
R:R:N288	R:R:V314	1.48	32	No	No	3	6	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.59
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD6
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I401	R:R:N400	2.83	2	Yes	Yes	3	6	2	1
R:R:N400	R:R:T402	14.62	2	Yes	No	6	1	1	1
R:R:N400	R:R:S403	4.47	2	Yes	No	6	3	1	1
H:H:?10	R:R:N400	33.07	2	No	Yes	0	6	0	1
R:R:M409	R:R:T402	3.01	2	Yes	No	6	1	2	1
H:H:?10	R:R:T402	9.2	2	No	No	0	1	0	1
H:H:?10	R:R:S403	4.02	2	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	15.43
Average Nodes In Shell	6.00
Average Hubs In Shell	3.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD6
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N468	R:R:Q476	3.96	35	No	No	8	6	1	1
R:R:D478	R:R:N468	5.39	0	No	No	9	8	2	1
H:H:?11	R:R:N468	25.72	35	No	No	0	8	0	1
R:R:Q476	R:R:T470	5.67	35	No	No	6	7	1	2
H:H:?11	R:R:Q476	14.25	35	No	No	0	6	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	19.98
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD6
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N288	S:S:T290	8.77	49	No	No	4	4	1	1
H:H:?12	S:S:N288	29.4	49	No	No	0	4	0	1
S:S:T290	S:S:V314	7.93	49	No	No	4	6	1	2
H:H:?12	S:S:T290	5.26	49	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	17.33
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD6
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N400	S:S:T402	10.24	25	No	No	7	2	1	1
S:S:N400	S:S:S403	7.45	25	No	No	7	4	1	1
H:H:?13	S:S:N400	30.62	25	No	No	0	7	0	1
H:H:?13	S:S:T402	14.46	25	No	No	0	2	0	1
H:H:?13	S:S:S403	2.68	25	No	No	0	4	0	1
S:S:I401	S:S:T402	1.52	0	No	No	4	2	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.92
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD6
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N468	S:S:Q476	6.6	26	No	No	8	6	1	1
S:S:D478	S:S:N468	10.77	26	No	No	8	8	1	1
H:H:?14	S:S:N468	29.4	26	No	No	0	8	0	1
S:S:Q476	S:S:T470	5.67	26	No	No	6	6	1	2
H:H:?14	S:S:Q476	14.25	26	No	No	0	6	0	1
H:H:?14	S:S:D478	3.63	26	No	No	0	8	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.76
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7DD7

Ion

Calcium-sensing

CaS

Gallus gallus

Ca; Ca; Tryptophan; Evocalcet

3.2

2021-06-16

10.1126/sciadv.abg1483

A 2D representation of the interactions of NAG in 7DD7
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H510	R:R:K324	7.86	1	Yes	No	6	5	1	2
R:R:H510	R:R:N488	3.83	1	Yes	Yes	6	8	1	1
R:R:N488	R:R:N512	12.26	1	Yes	Yes	8	3	1	1
R:R:N488	R:R:V513	4.43	1	Yes	Yes	8	3	1	2
R:R:N488	R:R:Y514	8.14	1	Yes	Yes	8	5	1	1
H:H:?1	R:R:N488	24.5	1	Yes	Yes	0	8	0	1
R:R:H510	R:R:N512	2.55	1	Yes	Yes	6	3	1	1
H:H:?1	R:R:H510	13.76	1	Yes	Yes	0	6	0	1
R:R:N512	R:R:Y514	8.14	1	Yes	Yes	3	5	1	1
H:H:?1	R:R:N512	17.15	1	Yes	Yes	0	3	0	1
H:H:?1	R:R:Y514	13.59	1	Yes	Yes	0	5	0	1
H:H:?1	H:H:?2	30.84	1	Yes	No	0	0	0	1
R:R:A515	R:R:N512	1.56	0	No	Yes	3	3	2	1
R:R:V486	R:R:Y514	1.26	0	No	Yes	6	5	2	1
R:R:F522	R:R:H510	1.13	0	No	Yes	7	6	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	19.97
Average Nodes In Shell	11.00
Average Hubs In Shell	6.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	15.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD7
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H510	R:R:N488	3.83	1	Yes	Yes	6	8	2	2
R:R:N488	R:R:N512	12.26	1	Yes	Yes	8	3	2	2
R:R:N488	R:R:Y514	8.14	1	Yes	Yes	8	5	2	2
H:H:?1	R:R:N488	24.5	1	Yes	Yes	0	8	1	2
R:R:H510	R:R:N512	2.55	1	Yes	Yes	6	3	2	2
H:H:?1	R:R:H510	13.76	1	Yes	Yes	0	6	1	2
R:R:N512	R:R:Y514	8.14	1	Yes	Yes	3	5	2	2
H:H:?1	R:R:N512	17.15	1	Yes	Yes	0	3	1	2
H:H:?1	R:R:Y514	13.59	1	Yes	Yes	0	5	1	2
H:H:?1	H:H:?2	30.84	1	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	30.84
Average Nodes In Shell	6.00
Average Hubs In Shell	5.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD7
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R206	6.5	7	Yes	No	0	9	0	1
H:H:?4	R:R:R206	9.75	7	No	No	0	9	1	1
R:R:N208	R:R:N541	12.26	7	No	No	9	9	1	1
R:R:C561	R:R:N208	4.72	7	No	No	9	9	2	1
H:H:?3	R:R:N208	11.02	7	Yes	No	0	9	0	1
R:R:F539	R:R:N541	6.04	7	No	No	9	9	1	1
H:H:?3	R:R:F539	4.35	7	Yes	No	0	9	0	1
H:H:?3	R:R:N541	25.72	7	Yes	No	0	9	0	1
H:H:?3	H:H:?4	33.04	7	Yes	No	0	0	0	1
R:R:F539	R:R:R544	1.07	7	No	No	9	5	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	16.13
Average Nodes In Shell	8.00
Average Hubs In Shell	1.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD7
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R206	6.5	7	Yes	No	0	9	1	1
H:H:?4	R:R:R206	9.75	7	No	No	0	9	0	1
R:R:N208	R:R:N541	12.26	7	No	No	9	9	2	2
H:H:?3	R:R:N208	11.02	7	Yes	No	0	9	1	2
R:R:F539	R:R:N541	6.04	7	No	No	9	9	2	2
H:H:?3	R:R:F539	4.35	7	Yes	No	0	9	1	2
H:H:?3	R:R:N541	25.72	7	Yes	No	0	9	1	2
H:H:?3	H:H:?4	33.04	7	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	21.39
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD7
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:K324	S:S:N488	2.8	16	No	Yes	5	8	2	1
S:S:H510	S:S:K324	6.55	16	Yes	No	5	5	1	2
S:S:V486	S:S:Y514	3.79	0	No	No	5	5	2	1
S:S:H510	S:S:N488	8.93	16	Yes	Yes	5	8	1	1
S:S:N488	S:S:N512	6.81	16	Yes	Yes	8	3	1	1
H:H:?5	S:S:N488	26.95	16	Yes	Yes	0	8	0	1
S:S:H510	S:S:N512	2.55	16	Yes	Yes	5	3	1	1
H:H:?5	S:S:H510	12.62	16	Yes	Yes	0	5	0	1
S:S:N512	S:S:Y514	5.81	16	Yes	No	3	5	1	1
H:H:?5	S:S:N512	19.6	16	Yes	Yes	0	3	0	1
H:H:?5	S:S:Y514	11.5	16	Yes	No	0	5	0	1
H:H:?5	H:H:?6	29.74	16	Yes	No	0	0	0	1
S:S:F522	S:S:H510	1.13	0	No	Yes	6	5	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	20.08
Average Nodes In Shell	9.00
Average Hubs In Shell	4.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD7
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:H510	S:S:N488	8.93	16	Yes	Yes	5	8	2	2
S:S:N488	S:S:N512	6.81	16	Yes	Yes	8	3	2	2
H:H:?5	S:S:N488	26.95	16	Yes	Yes	0	8	1	2
S:S:H510	S:S:N512	2.55	16	Yes	Yes	5	3	2	2
H:H:?5	S:S:H510	12.62	16	Yes	Yes	0	5	1	2
S:S:N512	S:S:Y514	5.81	16	Yes	No	3	5	2	2
H:H:?5	S:S:N512	19.6	16	Yes	Yes	0	3	1	2
H:H:?5	S:S:Y514	11.5	16	Yes	No	0	5	1	2
H:H:?5	H:H:?6	29.74	16	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	29.74
Average Nodes In Shell	6.00
Average Hubs In Shell	4.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD7
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?7	S:S:R206	4.33	5	Yes	No	0	9	0	1
H:H:?8	S:S:R206	15.17	5	No	No	0	9	1	1
S:S:N208	S:S:N541	12.26	5	No	No	9	9	1	1
S:S:C561	S:S:N208	4.72	5	Yes	No	9	9	2	1
H:H:?7	S:S:N208	7.35	5	Yes	No	0	9	0	1
S:S:F539	S:S:N541	8.46	5	No	No	9	9	1	1
H:H:?7	S:S:F539	5.43	5	Yes	No	0	9	0	1
H:H:?7	S:S:N541	25.72	5	Yes	No	0	9	0	1
H:H:?7	S:S:R544	3.25	5	Yes	No	0	6	0	1
S:S:D545	S:S:D578	13.31	0	No	Yes	9	7	1	2
H:H:?7	S:S:D545	6.05	5	Yes	No	0	9	0	1
H:H:?7	H:H:?8	39.65	5	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.11
Average Nodes In Shell	10.00
Average Hubs In Shell	3.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD7
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?7	S:S:R206	4.33	5	Yes	No	0	9	1	1
H:H:?8	S:S:R206	15.17	5	No	No	0	9	0	1
S:S:N208	S:S:N541	12.26	5	No	No	9	9	2	2
H:H:?7	S:S:N208	7.35	5	Yes	No	0	9	1	2
S:S:F539	S:S:N541	8.46	5	No	No	9	9	2	2
H:H:?7	S:S:F539	5.43	5	Yes	No	0	9	1	2
H:H:?7	S:S:N541	25.72	5	Yes	No	0	9	1	2
H:H:?7	S:S:R544	3.25	5	Yes	No	0	6	1	2
H:H:?7	S:S:D545	6.05	5	Yes	No	0	9	1	2
H:H:?7	H:H:?8	39.65	5	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	27.41
Average Nodes In Shell	8.00
Average Hubs In Shell	1.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD7
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N288	R:R:T290	4.39	39	No	No	3	4	1	1
H:H:?9	R:R:N288	30.62	39	No	No	0	3	0	1
H:H:?9	R:R:T290	6.57	39	No	No	0	4	0	1
R:R:G291	R:R:T290	1.82	0	No	No	6	4	2	1
R:R:N288	R:R:V314	1.48	39	No	No	3	6	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.59
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD7
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I401	R:R:N400	2.83	1	Yes	Yes	3	6	2	1
R:R:N400	R:R:T402	14.62	1	Yes	No	6	1	1	1
R:R:N400	R:R:S403	4.47	1	Yes	No	6	3	1	1
H:H:?10	R:R:N400	33.07	1	No	Yes	0	6	0	1
R:R:M409	R:R:T402	3.01	1	Yes	No	6	1	2	1
H:H:?10	R:R:T402	9.2	1	No	No	0	1	0	1
H:H:?10	R:R:S403	4.02	1	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	15.43
Average Nodes In Shell	6.00
Average Hubs In Shell	3.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD7
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D478	R:R:N468	5.39	No	No	9	8	2	1
H:H:?11	R:R:N468	25.72	No	No	0	8	0	1
H:H:?11	R:R:Q476	2.37	No	No	0	6	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.04
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD7
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N288	S:S:T290	8.77	49	No	No	4	4	1	1
H:H:?12	S:S:N288	29.4	49	No	No	0	4	0	1
S:S:T290	S:S:V314	7.93	49	No	No	4	6	1	2
H:H:?12	S:S:T290	5.26	49	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	17.33
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD7
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N400	S:S:T402	10.24	35	No	No	7	2	1	1
S:S:N400	S:S:S403	7.45	35	No	No	7	4	1	1
H:H:?13	S:S:N400	30.62	35	No	No	0	7	0	1
H:H:?13	S:S:T402	14.46	35	No	No	0	2	0	1
H:H:?13	S:S:S403	2.68	35	No	No	0	4	0	1
S:S:I401	S:S:T402	1.52	0	No	No	4	2	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.92
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DD7
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N468	S:S:Q476	6.6	36	No	No	8	6	1	1
S:S:D478	S:S:N468	10.77	36	No	No	8	8	1	1
H:H:?14	S:S:N468	29.4	36	No	No	0	8	0	1
H:H:?14	S:S:Q476	15.43	36	No	No	0	6	0	1
H:H:?14	S:S:D478	3.63	36	No	No	0	8	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	16.15
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7DTT

Ion

Calcium-sensing

CaS

Homo sapiens

3.8

2021-03-10

10.1038/s41422-021-00474-0

A 2D representation of the interactions of NAG in 7DTT
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N488	R:R:N512	6.81	24	Yes	Yes	4	4	1	1
R:R:N488	R:R:V513	5.91	24	Yes	Yes	4	3	1	2
R:R:N488	R:R:Y514	6.98	24	Yes	Yes	4	4	1	1
H:H:?1	R:R:N488	26.95	24	Yes	Yes	0	4	0	1
R:R:F522	R:R:Y510	15.47	0	No	No	1	3	2	1
H:H:?1	R:R:Y510	15.69	24	Yes	No	0	3	0	1
R:R:N512	R:R:Y514	5.81	24	Yes	Yes	4	4	1	1
R:R:A515	R:R:N512	3.13	0	No	Yes	4	4	2	1
H:H:?1	R:R:N512	17.15	24	Yes	Yes	0	4	0	1
R:R:V513	R:R:Y514	3.79	24	Yes	Yes	3	4	2	1
H:H:?1	R:R:Y514	13.59	24	Yes	Yes	0	4	0	1
H:H:?1	H:H:?2	34.14	24	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	21.50
Average Nodes In Shell	9.00
Average Hubs In Shell	5.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTT
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N488	R:R:N512	6.81	24	Yes	Yes	4	4	2	2
R:R:N488	R:R:Y514	6.98	24	Yes	Yes	4	4	2	2
H:H:?1	R:R:N488	26.95	24	Yes	Yes	0	4	1	2
H:H:?1	R:R:Y510	15.69	24	Yes	No	0	3	1	2
R:R:N512	R:R:Y514	5.81	24	Yes	Yes	4	4	2	2
H:H:?1	R:R:N512	17.15	24	Yes	Yes	0	4	1	2
H:H:?1	R:R:Y514	13.59	24	Yes	Yes	0	4	1	2
H:H:?1	H:H:?2	34.14	24	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	34.14
Average Nodes In Shell	6.00
Average Hubs In Shell	4.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTT
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R205	6.5	6	Yes	No	0	4	0	1
H:H:?4	R:R:R205	9.75	6	No	No	0	4	1	1
R:R:N207	R:R:N541	13.62	6	No	No	6	5	1	1
R:R:C561	R:R:N207	11.02	6	Yes	No	9	6	2	1
H:H:?3	R:R:N207	15.92	6	Yes	No	0	6	0	1
R:R:F539	R:R:N541	6.04	6	No	No	1	5	1	1
R:R:F539	R:R:R544	10.69	6	No	No	1	5	1	2
H:H:?3	R:R:F539	6.52	6	Yes	No	0	1	0	1
H:H:?3	R:R:N541	28.17	6	Yes	No	0	5	0	1
H:H:?3	H:H:?4	37.44	6	Yes	No	0	0	0	1
H:H:?4	H:H:?5	33.04	6	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.91
Average Nodes In Shell	9.00
Average Hubs In Shell	2.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTT
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R205	6.5	6	Yes	No	0	4	1	1
H:H:?4	R:R:R205	9.75	6	No	No	0	4	0	1
R:R:N207	R:R:N541	13.62	6	No	No	6	5	2	2
H:H:?3	R:R:N207	15.92	6	Yes	No	0	6	1	2
R:R:F539	R:R:N541	6.04	6	No	No	1	5	2	2
H:H:?3	R:R:F539	6.52	6	Yes	No	0	1	1	2
H:H:?3	R:R:N541	28.17	6	Yes	No	0	5	1	2
H:H:?3	H:H:?4	37.44	6	Yes	No	0	0	1	0
H:H:?4	H:H:?5	33.04	6	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	26.74
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTT
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R205	6.5	6	Yes	No	4	2	2
H:H:?4	R:R:R205	9.75	6	No	No	4	1	2
H:H:?3	H:H:?4	37.44	6	Yes	No	0	2	1
H:H:?4	H:H:?5	33.04	6	No	No	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	33.04
Average Nodes In Shell	4.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	2.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTT
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N488	S:S:N512	6.81	28	Yes	Yes	4	4	1	1
S:S:N488	S:S:V513	5.91	28	Yes	Yes	4	3	1	2
S:S:N488	S:S:Y514	6.98	28	Yes	Yes	4	4	1	1
H:H:?6	S:S:N488	26.95	28	Yes	Yes	0	4	0	1
S:S:F522	S:S:Y510	15.47	0	No	No	1	3	2	1
H:H:?6	S:S:Y510	15.69	28	Yes	No	0	3	0	1
S:S:N512	S:S:Y514	5.81	28	Yes	Yes	4	4	1	1
S:S:A515	S:S:N512	3.13	0	No	Yes	4	4	2	1
H:H:?6	S:S:N512	17.15	28	Yes	Yes	0	4	0	1
S:S:V513	S:S:Y514	3.79	28	Yes	Yes	3	4	2	1
H:H:?6	S:S:Y514	13.59	28	Yes	Yes	0	4	0	1
H:H:?6	H:H:?7	34.14	28	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	21.50
Average Nodes In Shell	9.00
Average Hubs In Shell	5.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTT
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N488	S:S:N512	6.81	28	Yes	Yes	4	4	2	2
S:S:N488	S:S:Y514	6.98	28	Yes	Yes	4	4	2	2
H:H:?6	S:S:N488	26.95	28	Yes	Yes	0	4	1	2
H:H:?6	S:S:Y510	15.69	28	Yes	No	0	3	1	2
S:S:N512	S:S:Y514	5.81	28	Yes	Yes	4	4	2	2
H:H:?6	S:S:N512	17.15	28	Yes	Yes	0	4	1	2
H:H:?6	S:S:Y514	13.59	28	Yes	Yes	0	4	1	2
H:H:?6	H:H:?7	34.14	28	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	34.14
Average Nodes In Shell	6.00
Average Hubs In Shell	4.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTT
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?8	S:S:R205	6.5	9	Yes	No	0	4	0	1
H:H:?9	S:S:R205	9.75	9	No	No	0	4	1	1
S:S:N207	S:S:N541	13.62	9	No	No	6	5	1	1
S:S:C561	S:S:N207	11.02	9	Yes	No	9	6	2	1
H:H:?8	S:S:N207	15.92	9	Yes	No	0	6	0	1
S:S:F539	S:S:N541	6.04	9	No	No	1	5	1	1
S:S:F539	S:S:R544	10.69	9	No	No	1	5	1	2
H:H:?8	S:S:F539	6.52	9	Yes	No	0	1	0	1
H:H:?8	S:S:N541	28.17	9	Yes	No	0	5	0	1
H:H:?8	H:H:?9	37.44	9	Yes	No	0	0	0	1
H:H:?10	H:H:?9	33.04	0	No	No	0	0	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.91
Average Nodes In Shell	9.00
Average Hubs In Shell	2.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTT
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?8	S:S:R205	6.5	9	Yes	No	0	4	1	1
H:H:?9	S:S:R205	9.75	9	No	No	0	4	0	1
S:S:N207	S:S:N541	13.62	9	No	No	6	5	2	2
H:H:?8	S:S:N207	15.92	9	Yes	No	0	6	1	2
S:S:F539	S:S:N541	6.04	9	No	No	1	5	2	2
H:H:?8	S:S:F539	6.52	9	Yes	No	0	1	1	2
H:H:?8	S:S:N541	28.17	9	Yes	No	0	5	1	2
H:H:?8	H:H:?9	37.44	9	Yes	No	0	0	1	0
H:H:?10	H:H:?9	33.04	0	No	No	0	0	1	0

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	26.74
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTT
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?8	S:S:R205	6.5	9	Yes	No	4	2	2
H:H:?9	S:S:R205	9.75	9	No	No	4	1	2
H:H:?8	H:H:?9	37.44	9	Yes	No	0	2	1
H:H:?10	H:H:?9	33.04	0	No	No	0	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	33.04
Average Nodes In Shell	4.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	2.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTT
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E257	R:R:Q253	6.37	No	No	3	3	1	2
H:H:?11	R:R:E257	5.91	No	No	0	3	0	1
H:H:?11	R:R:N261	25.72	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.81
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTT
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N287	R:R:T289	2.92	No	No	6	5	1	2
H:H:?12	R:R:N287	35.52	No	No	0	6	0	1
R:R:H312	R:R:N287	1.28	No	No	3	6	2	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	35.52
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTT
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?13	R:R:N446	35.52	No	No	0	3	0	1
H:H:?13	R:R:S448	2.68	No	No	0	3	0	1
R:R:S448	R:R:T445	1.6	No	No	3	1	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	19.10
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTT
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N468	R:R:Q476	6.6	33	No	No	6	3	1	1
R:R:N468	R:R:T478	5.85	33	No	No	6	3	1	1
H:H:?14	R:R:N468	33.07	33	No	No	0	6	0	1
R:R:Q476	R:R:T470	8.5	33	No	No	3	5	1	2
H:H:?14	R:R:Q476	3.56	33	No	No	0	3	0	1
H:H:?14	R:R:T478	5.26	33	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.96
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTT
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:E257	S:S:Q253	6.37	No	No	3	3	1	2
H:H:?15	S:S:E257	5.91	No	No	0	3	0	1
H:H:?15	S:S:N261	25.72	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.81
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTT
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N287	S:S:T289	2.92	No	No	6	5	1	2
H:H:?16	S:S:N287	35.52	No	No	0	6	0	1
S:S:H312	S:S:N287	1.28	No	No	3	6	2	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	35.52
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTT
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?17	S:S:N446	35.52	No	No	0	3	0	1
H:H:?17	S:S:S448	2.68	No	No	0	3	0	1
S:S:S448	S:S:T445	1.6	No	No	3	1	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	19.10
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTT
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N468	S:S:Q476	6.6	37	No	No	6	3	1	1
S:S:N468	S:S:T478	5.85	37	No	No	6	3	1	1
H:H:?18	S:S:N468	33.07	37	No	No	0	6	0	1
S:S:Q476	S:S:T470	8.5	37	No	No	3	5	1	2
H:H:?18	S:S:Q476	3.56	37	No	No	0	3	0	1
H:H:?18	S:S:T478	5.26	37	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.96
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7DTU

Ion

Calcium-sensing

CaS

Homo sapiens

Tryptophan

4.4

2021-03-10

10.1038/s41422-021-00474-0

A 2D representation of the interactions of NAG in 7DTU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:G487	R:R:Y514	4.35	0	No	Yes	6	4	2	1
R:R:N488	R:R:N512	6.81	25	Yes	No	4	4	1	1
R:R:N488	R:R:V513	2.96	25	Yes	Yes	4	3	1	2
R:R:N488	R:R:Y514	6.98	25	Yes	Yes	4	4	1	1
H:H:?1	R:R:N488	23.27	25	Yes	Yes	0	4	0	1
R:R:G509	R:R:Y510	2.9	0	No	No	9	3	2	1
R:R:F522	R:R:Y510	9.28	0	No	No	1	3	2	1
H:H:?1	R:R:Y510	6.27	25	Yes	No	0	3	0	1
R:R:N512	R:R:Y514	8.14	25	No	Yes	4	4	1	1
H:H:?1	R:R:N512	22.05	25	Yes	No	0	4	0	1
R:R:V513	R:R:Y514	5.05	25	Yes	Yes	3	4	2	1
H:H:?1	R:R:Y514	17.78	25	Yes	Yes	0	4	0	1
H:H:?1	H:H:?2	38.55	25	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	21.58
Average Nodes In Shell	10.00
Average Hubs In Shell	4.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N488	R:R:N512	6.81	25	Yes	No	4	4	2	2
R:R:N488	R:R:Y514	6.98	25	Yes	Yes	4	4	2	2
H:H:?1	R:R:N488	23.27	25	Yes	Yes	0	4	1	2
H:H:?1	R:R:Y510	6.27	25	Yes	No	0	3	1	2
R:R:N512	R:R:Y514	8.14	25	No	Yes	4	4	2	2
H:H:?1	R:R:N512	22.05	25	Yes	No	0	4	1	2
H:H:?1	R:R:Y514	17.78	25	Yes	Yes	0	4	1	2
H:H:?1	H:H:?2	38.55	25	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	38.55
Average Nodes In Shell	6.00
Average Hubs In Shell	3.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R205	10.84	7	Yes	No	0	4	0	1
H:H:?4	R:R:R205	15.17	7	No	No	0	4	1	1
R:R:I235	R:R:N207	2.83	0	No	Yes	7	6	2	1
R:R:C236	R:R:N207	4.72	7	No	Yes	9	6	2	1
R:R:C561	R:R:N207	7.87	7	No	Yes	9	6	2	1
H:H:?3	R:R:N207	7.35	7	Yes	Yes	0	6	0	1
R:R:C236	R:R:C561	7.28	7	No	No	9	9	2	2
R:R:F539	R:R:K265	3.72	7	Yes	No	1	5	1	2
R:R:F539	R:R:N541	7.25	7	Yes	No	1	5	1	1
R:R:F539	R:R:R544	22.45	7	Yes	No	1	5	1	2
H:H:?3	R:R:F539	7.6	7	Yes	Yes	0	1	0	1
H:H:?3	R:R:N541	30.62	7	Yes	No	0	5	0	1
H:H:?3	H:H:?4	33.04	7	Yes	No	0	0	0	1
R:R:N207	R:R:T560	1.46	7	Yes	No	6	4	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	17.89
Average Nodes In Shell	12.00
Average Hubs In Shell	3.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R205	10.84	7	Yes	No	0	4	1	1
H:H:?4	R:R:R205	15.17	7	No	No	0	4	0	1
H:H:?3	R:R:N207	7.35	7	Yes	Yes	0	6	1	2
R:R:F539	R:R:N541	7.25	7	Yes	No	1	5	2	2
H:H:?3	R:R:F539	7.6	7	Yes	Yes	0	1	1	2
H:H:?3	R:R:N541	30.62	7	Yes	No	0	5	1	2
H:H:?3	H:H:?4	33.04	7	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	24.11
Average Nodes In Shell	6.00
Average Hubs In Shell	3.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:G487	S:S:Y514	4.35	0	No	Yes	6	4	2	1
S:S:N488	S:S:N512	6.81	27	Yes	No	4	4	1	1
S:S:N488	S:S:V513	2.96	27	Yes	Yes	4	3	1	2
S:S:N488	S:S:Y514	6.98	27	Yes	Yes	4	4	1	1
H:H:?5	S:S:N488	23.27	27	Yes	Yes	0	4	0	1
S:S:G509	S:S:Y510	2.9	0	No	No	9	3	2	1
S:S:F522	S:S:Y510	9.28	0	No	No	1	3	2	1
H:H:?5	S:S:Y510	6.27	27	Yes	No	0	3	0	1
S:S:N512	S:S:Y514	8.14	27	No	Yes	4	4	1	1
H:H:?5	S:S:N512	22.05	27	Yes	No	0	4	0	1
S:S:V513	S:S:Y514	5.05	27	Yes	Yes	3	4	2	1
H:H:?5	S:S:Y514	17.78	27	Yes	Yes	0	4	0	1
H:H:?5	H:H:?6	38.55	27	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	21.58
Average Nodes In Shell	10.00
Average Hubs In Shell	4.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N488	S:S:N512	6.81	27	Yes	No	4	4	2	2
S:S:N488	S:S:Y514	6.98	27	Yes	Yes	4	4	2	2
H:H:?5	S:S:N488	23.27	27	Yes	Yes	0	4	1	2
H:H:?5	S:S:Y510	6.27	27	Yes	No	0	3	1	2
S:S:N512	S:S:Y514	8.14	27	No	Yes	4	4	2	2
H:H:?5	S:S:N512	22.05	27	Yes	No	0	4	1	2
H:H:?5	S:S:Y514	17.78	27	Yes	Yes	0	4	1	2
H:H:?5	H:H:?6	38.55	27	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	38.55
Average Nodes In Shell	6.00
Average Hubs In Shell	3.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?7	S:S:R205	10.84	9	Yes	No	0	4	0	1
H:H:?8	S:S:R205	15.17	9	No	No	0	4	1	1
S:S:I235	S:S:N207	2.83	0	No	Yes	7	6	2	1
S:S:C236	S:S:N207	4.72	9	No	Yes	9	6	2	1
S:S:C561	S:S:N207	7.87	9	No	Yes	9	6	2	1
H:H:?7	S:S:N207	7.35	9	Yes	Yes	0	6	0	1
S:S:C236	S:S:C561	7.28	9	No	No	9	9	2	2
S:S:F539	S:S:K265	3.72	9	Yes	No	1	5	1	2
S:S:F539	S:S:N541	7.25	9	Yes	No	1	5	1	1
S:S:F539	S:S:R544	22.45	9	Yes	No	1	5	1	2
H:H:?7	S:S:F539	7.6	9	Yes	Yes	0	1	0	1
H:H:?7	S:S:N541	30.62	9	Yes	No	0	5	0	1
H:H:?7	H:H:?8	33.04	9	Yes	No	0	0	0	1
S:S:N207	S:S:T560	1.46	9	Yes	No	6	4	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	17.89
Average Nodes In Shell	12.00
Average Hubs In Shell	3.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?7	S:S:R205	10.84	9	Yes	No	0	4	1	1
H:H:?8	S:S:R205	15.17	9	No	No	0	4	0	1
H:H:?7	S:S:N207	7.35	9	Yes	Yes	0	6	1	2
S:S:F539	S:S:N541	7.25	9	Yes	No	1	5	2	2
H:H:?7	S:S:F539	7.6	9	Yes	Yes	0	1	1	2
H:H:?7	S:S:N541	30.62	9	Yes	No	0	5	1	2
H:H:?7	H:H:?8	33.04	9	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	24.11
Average Nodes In Shell	6.00
Average Hubs In Shell	3.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?9	R:R:N287	34.3	No	No	0	6	0	1
H:H:?9	R:R:T289	6.57	No	No	0	5	0	1
R:R:G290	R:R:T289	1.82	No	No	4	5	2	1
R:R:T289	R:R:V313	1.59	No	No	5	3	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	20.43
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?10	R:R:T445	5.26	0	No	No	0	1	0	1
H:H:?10	R:R:N446	35.52	0	No	No	0	3	0	1
H:H:?10	R:R:S448	2.68	0	No	No	0	3	0	1
R:R:F444	R:R:S448	1.32	13	Yes	No	3	3	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.49
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N468	R:R:Q476	5.28	32	No	Yes	6	3	1	1
R:R:N468	R:R:T478	5.85	32	No	No	6	3	1	2
H:H:?11	R:R:N468	31.85	32	No	No	0	6	0	1
R:R:Q476	R:R:T470	7.09	32	Yes	No	3	5	1	2
R:R:Q476	R:R:T478	4.25	32	Yes	No	3	3	1	2
H:H:?11	R:R:Q476	5.94	32	No	Yes	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	18.89
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?12	S:S:N287	34.3	No	No	0	6	0	1
H:H:?12	S:S:T289	6.57	No	No	0	5	0	1
S:S:G290	S:S:T289	1.82	No	No	4	5	2	1
S:S:T289	S:S:V313	1.59	No	No	5	3	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	20.43
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?13	S:S:T445	5.26	0	No	No	0	1	0	1
H:H:?13	S:S:N446	35.52	0	No	No	0	3	0	1
H:H:?13	S:S:S448	2.68	0	No	No	0	3	0	1
S:S:F444	S:S:S448	1.32	12	Yes	No	3	3	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.49
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N468	S:S:Q476	5.28	36	No	Yes	6	3	1	1
S:S:N468	S:S:T478	5.85	36	No	No	6	3	1	2
H:H:?14	S:S:N468	31.85	36	No	No	0	6	0	1
S:S:Q476	S:S:T470	7.09	36	Yes	No	3	5	1	2
S:S:Q476	S:S:T478	4.25	36	Yes	No	3	3	1	2
H:H:?14	S:S:Q476	5.94	36	No	Yes	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	18.89
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7DTV

Ion

Calcium-sensing

CaS

Homo sapiens

Ca; Tryptophan

3.5

2021-03-10

10.1038/s41422-021-00474-0

A 2D representation of the interactions of NAG in 7DTV
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V486	R:R:Y514	3.79	0	No	Yes	3	4	2	1
R:R:N488	R:R:N512	5.45	21	Yes	Yes	4	4	1	1
R:R:N488	R:R:V513	5.91	21	Yes	No	4	3	1	2
R:R:N488	R:R:Y514	6.98	21	Yes	Yes	4	4	1	1
H:H:?1	R:R:N488	28.17	21	Yes	Yes	0	4	0	1
R:R:F522	R:R:Y510	14.44	0	No	No	1	3	2	1
H:H:?1	R:R:Y510	13.59	21	Yes	No	0	3	0	1
R:R:N512	R:R:Y514	3.49	21	Yes	Yes	4	4	1	1
R:R:A515	R:R:N512	3.13	0	No	Yes	4	4	2	1
H:H:?1	R:R:N512	18.37	21	Yes	Yes	0	4	0	1
H:H:?2	R:R:N512	3.67	21	No	Yes	0	4	1	1
H:H:?1	R:R:Y514	11.5	21	Yes	Yes	0	4	0	1
H:H:?1	H:H:?2	27.53	21	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	19.83
Average Nodes In Shell	10.00
Average Hubs In Shell	4.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTV
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N488	R:R:N512	5.45	21	Yes	Yes	4	4	2	1
R:R:N488	R:R:Y514	6.98	21	Yes	Yes	4	4	2	2
H:H:?1	R:R:N488	28.17	21	Yes	Yes	0	4	1	2
H:H:?1	R:R:Y510	13.59	21	Yes	No	0	3	1	2
R:R:N512	R:R:Y514	3.49	21	Yes	Yes	4	4	1	2
R:R:A515	R:R:N512	3.13	0	No	Yes	4	4	2	1
H:H:?1	R:R:N512	18.37	21	Yes	Yes	0	4	1	1
H:H:?2	R:R:N512	3.67	21	No	Yes	0	4	0	1
H:H:?1	R:R:Y514	11.5	21	Yes	Yes	0	4	1	2
H:H:?1	H:H:?2	27.53	21	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	15.60
Average Nodes In Shell	7.00
Average Hubs In Shell	4.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTV
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R205	4.33	6	Yes	No	0	4	0	1
H:H:?4	R:R:R205	5.42	6	No	No	0	4	1	1
R:R:C236	R:R:N207	3.15	6	No	Yes	9	6	2	1
R:R:N207	R:R:N541	10.9	6	Yes	No	6	5	1	1
R:R:C561	R:R:N207	4.72	6	No	Yes	9	6	2	1
H:H:?3	R:R:N207	15.92	6	Yes	Yes	0	6	0	1
R:R:C236	R:R:C561	7.28	6	No	No	9	9	2	2
R:R:F539	R:R:N541	7.25	6	No	No	1	5	1	1
R:R:F539	R:R:R544	27.79	6	No	No	1	5	1	2
H:H:?3	R:R:F539	4.35	6	Yes	No	0	1	0	1
H:H:?3	R:R:N541	25.72	6	Yes	No	0	5	0	1
H:H:?3	H:H:?4	35.24	6	Yes	No	0	0	0	1
H:H:?4	H:H:?5	34.14	6	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	17.11
Average Nodes In Shell	10.00
Average Hubs In Shell	2.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTV
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R205	4.33	6	Yes	No	0	4	1	1
H:H:?4	R:R:R205	5.42	6	No	No	0	4	0	1
R:R:N207	R:R:N541	10.9	6	Yes	No	6	5	2	2
H:H:?3	R:R:N207	15.92	6	Yes	Yes	0	6	1	2
R:R:F539	R:R:N541	7.25	6	No	No	1	5	2	2
H:H:?3	R:R:F539	4.35	6	Yes	No	0	1	1	2
H:H:?3	R:R:N541	25.72	6	Yes	No	0	5	1	2
H:H:?3	H:H:?4	35.24	6	Yes	No	0	0	1	0
H:H:?4	H:H:?5	34.14	6	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	24.93
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTV
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R205	4.33	6	Yes	No	4	2	2
H:H:?4	R:R:R205	5.42	6	No	No	4	1	2
H:H:?3	H:H:?4	35.24	6	Yes	No	0	2	1
H:H:?4	H:H:?5	34.14	6	No	No	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	34.14
Average Nodes In Shell	4.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	2.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTV
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:V486	S:S:Y514	3.79	0	No	Yes	3	4	2	1
S:S:N488	S:S:N512	5.45	25	Yes	Yes	4	4	1	1
S:S:N488	S:S:V513	5.91	25	Yes	No	4	3	1	2
S:S:N488	S:S:Y514	6.98	25	Yes	Yes	4	4	1	1
H:H:?6	S:S:N488	28.17	25	Yes	Yes	0	4	0	1
S:S:F522	S:S:Y510	14.44	0	No	No	1	3	2	1
H:H:?6	S:S:Y510	13.59	25	Yes	No	0	3	0	1
S:S:N512	S:S:Y514	3.49	25	Yes	Yes	4	4	1	1
S:S:A515	S:S:N512	3.13	0	No	Yes	4	4	2	1
H:H:?6	S:S:N512	18.37	25	Yes	Yes	0	4	0	1
H:H:?7	S:S:N512	3.67	25	No	Yes	0	4	1	1
H:H:?6	S:S:Y514	11.5	25	Yes	Yes	0	4	0	1
H:H:?6	H:H:?7	27.53	25	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	19.83
Average Nodes In Shell	10.00
Average Hubs In Shell	4.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTV
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N488	S:S:N512	5.45	25	Yes	Yes	4	4	2	1
S:S:N488	S:S:Y514	6.98	25	Yes	Yes	4	4	2	2
H:H:?6	S:S:N488	28.17	25	Yes	Yes	0	4	1	2
H:H:?6	S:S:Y510	13.59	25	Yes	No	0	3	1	2
S:S:N512	S:S:Y514	3.49	25	Yes	Yes	4	4	1	2
S:S:A515	S:S:N512	3.13	0	No	Yes	4	4	2	1
H:H:?6	S:S:N512	18.37	25	Yes	Yes	0	4	1	1
H:H:?7	S:S:N512	3.67	25	No	Yes	0	4	0	1
H:H:?6	S:S:Y514	11.5	25	Yes	Yes	0	4	1	2
H:H:?6	H:H:?7	27.53	25	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	15.60
Average Nodes In Shell	7.00
Average Hubs In Shell	4.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTV
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?8	S:S:R205	4.33	8	Yes	No	0	4	0	1
H:H:?9	S:S:R205	5.42	8	No	No	0	4	1	1
S:S:C236	S:S:N207	3.15	8	No	Yes	9	6	2	1
S:S:N207	S:S:N541	10.9	8	Yes	No	6	5	1	1
S:S:C561	S:S:N207	4.72	8	No	Yes	9	6	2	1
H:H:?8	S:S:N207	15.92	8	Yes	Yes	0	6	0	1
S:S:C236	S:S:C561	7.28	8	No	No	9	9	2	2
S:S:F539	S:S:N541	7.25	8	No	No	1	5	1	1
S:S:F539	S:S:R544	27.79	8	No	No	1	5	1	2
H:H:?8	S:S:F539	4.35	8	Yes	No	0	1	0	1
H:H:?8	S:S:N541	25.72	8	Yes	No	0	5	0	1
H:H:?8	H:H:?9	35.24	8	Yes	No	0	0	0	1
H:H:?10	H:H:?9	34.14	0	No	No	0	0	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	17.11
Average Nodes In Shell	10.00
Average Hubs In Shell	2.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTV
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?8	S:S:R205	4.33	8	Yes	No	0	4	1	1
H:H:?9	S:S:R205	5.42	8	No	No	0	4	0	1
S:S:N207	S:S:N541	10.9	8	Yes	No	6	5	2	2
H:H:?8	S:S:N207	15.92	8	Yes	Yes	0	6	1	2
S:S:F539	S:S:N541	7.25	8	No	No	1	5	2	2
H:H:?8	S:S:F539	4.35	8	Yes	No	0	1	1	2
H:H:?8	S:S:N541	25.72	8	Yes	No	0	5	1	2
H:H:?8	H:H:?9	35.24	8	Yes	No	0	0	1	0
H:H:?10	H:H:?9	34.14	0	No	No	0	0	1	0

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	24.93
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTV
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?8	S:S:R205	4.33	8	Yes	No	4	2	2
H:H:?9	S:S:R205	5.42	8	No	No	4	1	2
H:H:?8	H:H:?9	35.24	8	Yes	No	0	2	1
H:H:?10	H:H:?9	34.14	0	No	No	0	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	34.14
Average Nodes In Shell	4.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	2.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTV
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E257	R:R:Q253	6.37	No	No	3	3	1	2
H:H:?11	R:R:N261	30.62	No	No	0	4	0	1
H:H:?11	R:R:E257	2.36	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	16.49
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTV
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?12	R:R:N287	29.4	0	No	No	0	6	0	1
R:R:N287	R:R:T289	2.92	0	No	No	6	5	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	29.40
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTV
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?13	R:R:N446	35.52	0	No	No	0	3	0	1
H:H:?13	R:R:S448	2.68	0	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	19.10
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTV
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N468	R:R:Q476	3.96	No	No	6	3	1	2
H:H:?14	R:R:N468	26.95	No	No	0	6	0	1
H:H:?14	R:R:T478	3.94	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.45
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTV
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:E257	S:S:Q253	6.37	No	No	3	3	1	2
H:H:?15	S:S:N261	30.62	No	No	0	4	0	1
H:H:?15	S:S:E257	2.36	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	16.49
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTV
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?16	S:S:N287	29.4	0	No	No	0	6	0	1
S:S:N287	S:S:T289	2.92	0	No	No	6	5	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	29.40
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTV
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?17	S:S:N446	35.52	0	No	No	0	3	0	1
H:H:?17	S:S:S448	2.68	0	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	19.10
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTV
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N468	S:S:Q476	3.96	No	No	6	3	1	2
H:H:?18	S:S:N468	26.95	No	No	0	6	0	1
H:H:?18	S:S:T478	3.94	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.45
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7DTW

Ion

Calcium-sensing

CaS

Homo sapiens

4.5

2021-03-10

10.1038/s41422-021-00474-0

A 2D representation of the interactions of NAG in 7DTW
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:G487	R:R:Y514	2.9	0	No	Yes	6	4	2	1
R:R:N488	R:R:N512	9.54	30	Yes	No	4	4	1	1
R:R:N488	R:R:V513	5.91	30	Yes	Yes	4	3	1	2
R:R:N488	R:R:Y514	6.98	30	Yes	Yes	4	4	1	1
H:H:?1	R:R:N488	25.72	30	Yes	Yes	0	4	0	1
H:H:?2	R:R:Y510	5.23	0	No	No	0	3	1	2
R:R:N512	R:R:Y514	8.14	30	No	Yes	4	4	1	1
H:H:?1	R:R:N512	17.15	30	Yes	No	0	4	0	1
R:R:V513	R:R:Y514	8.83	30	Yes	Yes	3	4	2	1
H:H:?1	R:R:Y514	15.69	30	Yes	Yes	0	4	0	1
H:H:?1	H:H:?2	33.04	30	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	22.90
Average Nodes In Shell	8.00
Average Hubs In Shell	4.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTW
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N488	R:R:N512	9.54	30	Yes	No	4	4	2	2
R:R:N488	R:R:Y514	6.98	30	Yes	Yes	4	4	2	2
H:H:?1	R:R:N488	25.72	30	Yes	Yes	0	4	1	2
R:R:E507	R:R:Y510	4.49	0	No	No	5	3	2	1
R:R:F522	R:R:Y510	14.44	0	No	No	1	3	2	1
H:H:?2	R:R:Y510	5.23	0	No	No	0	3	0	1
R:R:N512	R:R:Y514	8.14	30	No	Yes	4	4	2	2
H:H:?1	R:R:N512	17.15	30	Yes	No	0	4	1	2
H:H:?1	R:R:Y514	15.69	30	Yes	Yes	0	4	1	2
H:H:?1	H:H:?2	33.04	30	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	19.13
Average Nodes In Shell	8.00
Average Hubs In Shell	3.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTW
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E202	R:R:R205	11.63	0	No	No	5	4	2	1
H:H:?3	R:R:R205	14.09	5	Yes	No	0	4	0	1
H:H:?4	R:R:R205	6.5	5	No	No	0	4	1	1
R:R:N207	R:R:N541	14.98	5	No	Yes	6	5	1	1
H:H:?3	R:R:N207	20.82	5	Yes	No	0	6	0	1
R:R:F539	R:R:N541	13.29	0	No	Yes	1	5	2	1
H:H:?3	R:R:N541	26.95	5	Yes	Yes	0	5	0	1
H:H:?3	H:H:?4	39.65	5	Yes	No	0	0	0	1
R:R:N541	R:R:W206	2.26	5	Yes	Yes	5	9	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	25.38
Average Nodes In Shell	8.00
Average Hubs In Shell	3.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTW
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E202	R:R:R205	11.63	0	No	No	5	4	2	1
H:H:?3	R:R:R205	14.09	5	Yes	No	0	4	1	1
H:H:?4	R:R:R205	6.5	5	No	No	0	4	0	1
R:R:N207	R:R:N541	14.98	5	No	Yes	6	5	2	2
H:H:?3	R:R:N207	20.82	5	Yes	No	0	6	1	2
H:H:?3	R:R:N541	26.95	5	Yes	Yes	0	5	1	2
H:H:?3	H:H:?4	39.65	5	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	23.07
Average Nodes In Shell	6.00
Average Hubs In Shell	2.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTW
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:G487	S:S:Y514	2.9	0	No	Yes	6	4	2	1
S:S:N488	S:S:N512	9.54	34	Yes	No	4	4	1	1
S:S:N488	S:S:V513	5.91	34	Yes	Yes	4	3	1	2
S:S:N488	S:S:Y514	6.98	34	Yes	Yes	4	4	1	1
H:H:?5	S:S:N488	25.72	34	Yes	Yes	0	4	0	1
H:H:?6	S:S:Y510	5.23	0	No	No	0	3	1	2
S:S:N512	S:S:Y514	8.14	34	No	Yes	4	4	1	1
H:H:?5	S:S:N512	17.15	34	Yes	No	0	4	0	1
S:S:V513	S:S:Y514	8.83	34	Yes	Yes	3	4	2	1
H:H:?5	S:S:Y514	15.69	34	Yes	Yes	0	4	0	1
H:H:?5	H:H:?6	33.04	34	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	22.90
Average Nodes In Shell	8.00
Average Hubs In Shell	4.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTW
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N488	S:S:N512	9.54	34	Yes	No	4	4	2	2
S:S:N488	S:S:Y514	6.98	34	Yes	Yes	4	4	2	2
H:H:?5	S:S:N488	25.72	34	Yes	Yes	0	4	1	2
S:S:E507	S:S:Y510	4.49	0	No	No	5	3	2	1
S:S:F522	S:S:Y510	14.44	0	No	No	1	3	2	1
H:H:?6	S:S:Y510	5.23	0	No	No	0	3	0	1
S:S:N512	S:S:Y514	8.14	34	No	Yes	4	4	2	2
H:H:?5	S:S:N512	17.15	34	Yes	No	0	4	1	2
H:H:?5	S:S:Y514	15.69	34	Yes	Yes	0	4	1	2
H:H:?5	H:H:?6	33.04	34	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	19.13
Average Nodes In Shell	8.00
Average Hubs In Shell	3.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTW
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:E202	S:S:R205	11.63	0	No	No	5	4	2	1
H:H:?7	S:S:R205	14.09	6	Yes	No	0	4	0	1
H:H:?8	S:S:R205	6.5	6	No	No	0	4	1	1
S:S:N207	S:S:N541	14.98	6	No	Yes	6	5	1	1
H:H:?7	S:S:N207	20.82	6	Yes	No	0	6	0	1
S:S:F539	S:S:N541	13.29	0	No	Yes	1	5	2	1
H:H:?7	S:S:N541	26.95	6	Yes	Yes	0	5	0	1
H:H:?7	H:H:?8	39.65	6	Yes	No	0	0	0	1
S:S:N541	S:S:W206	2.26	6	Yes	Yes	5	9	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	25.38
Average Nodes In Shell	8.00
Average Hubs In Shell	3.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTW
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:E202	S:S:R205	11.63	0	No	No	5	4	2	1
H:H:?7	S:S:R205	14.09	6	Yes	No	0	4	1	1
H:H:?8	S:S:R205	6.5	6	No	No	0	4	0	1
S:S:N207	S:S:N541	14.98	6	No	Yes	6	5	2	2
H:H:?7	S:S:N207	20.82	6	Yes	No	0	6	1	2
H:H:?7	S:S:N541	26.95	6	Yes	Yes	0	5	1	2
H:H:?7	H:H:?8	39.65	6	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	23.07
Average Nodes In Shell	6.00
Average Hubs In Shell	2.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTW
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?9	R:R:N287	35.52	No	No	0	6	0	1
H:H:?9	R:R:T289	13.15	No	No	0	5	0	1
R:R:G290	R:R:T289	1.82	No	No	4	5	2	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	24.34
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTW
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?10	R:R:N446	26.95	0	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	26.95
Average Nodes In Shell	2.00
Average Hubs In Shell	0.00
Average Links In Shell	1.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTW
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N468	R:R:Q476	9.24	39	No	Yes	6	3	1	1
R:R:N468	R:R:T478	4.39	39	No	No	6	3	1	2
H:H:?11	R:R:N468	36.74	39	No	No	0	6	0	1
R:R:Q476	R:R:T478	4.25	39	Yes	No	3	3	1	2
H:H:?11	R:R:Q476	3.56	39	No	Yes	0	3	0	1
R:R:Q476	R:R:T470	1.42	39	Yes	No	3	5	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	20.15
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTW
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?12	S:S:N287	35.52	No	No	0	6	0	1
H:H:?12	S:S:T289	13.15	No	No	0	5	0	1
S:S:G290	S:S:T289	1.82	No	No	4	5	2	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	24.34
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTW
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?13	S:S:N446	26.95	0	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	26.95
Average Nodes In Shell	2.00
Average Hubs In Shell	0.00
Average Links In Shell	1.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7DTW
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N468	S:S:Q476	9.24	42	No	Yes	6	3	1	1
S:S:N468	S:S:T478	2.92	42	No	No	6	3	1	2
H:H:?14	S:S:N468	36.74	42	No	No	0	6	0	1
S:S:Q476	S:S:T478	4.25	42	Yes	No	3	3	1	2
H:H:?14	S:S:Q476	3.56	42	No	Yes	0	3	0	1
S:S:Q476	S:S:T470	1.42	42	Yes	No	3	5	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	20.15
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7E6T

Ion

Calcium-sensing

CaS

Homo sapiens

Ca; Ca; Cyclomethyltryptophan; PO4

2021-09-22

10.7554/eLife.68578

A 2D representation of the interactions of NAG in 7E6T
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	S:S:K323	3.77	51	Yes	No	0	5	0	1
S:S:E475	S:S:N471	2.63	0	No	Yes	5	6	1	2
H:H:?1	S:S:E475	3.55	51	Yes	No	0	5	0	1
S:S:V486	S:S:Y514	5.05	0	No	Yes	3	4	2	1
H:H:?1	S:S:N488	28.17	51	Yes	No	0	4	0	1
S:S:N512	S:S:Y514	3.49	51	No	Yes	4	4	1	1
S:S:A515	S:S:N512	3.13	0	No	No	4	4	2	1
H:H:?1	S:S:N512	11.02	51	Yes	No	0	4	0	1
S:S:V513	S:S:Y514	7.57	0	No	Yes	3	4	2	1
H:H:?1	S:S:Y514	7.32	51	Yes	Yes	0	4	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	10.77
Average Nodes In Shell	10.00
Average Hubs In Shell	3.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7E6T
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?2	S:S:R205	6.5	34	Yes	No	0	4	0	1
S:S:N207	S:S:N541	9.54	34	No	No	6	5	1	1
H:H:?2	S:S:N207	7.35	34	Yes	No	0	6	0	1
S:S:F539	S:S:N541	9.67	34	No	No	1	5	1	1
S:S:F539	S:S:R544	11.76	34	No	No	1	5	1	2
H:H:?2	S:S:F539	6.52	34	Yes	No	0	1	0	1
H:H:?2	S:S:N541	22.05	34	Yes	No	0	5	0	1
S:S:D545	S:S:T577	2.89	0	No	No	5	5	1	2
S:S:D545	S:S:D578	2.66	0	No	No	5	7	1	2
H:H:?2	S:S:D545	3.63	34	Yes	No	0	5	0	1
S:S:C561	S:S:N207	1.57	0	No	No	9	6	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	9.21
Average Nodes In Shell	10.00
Average Hubs In Shell	1.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7E6T
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V486	R:R:V513	3.21	1	No	Yes	3	3	2	2
R:R:V486	R:R:Y514	3.79	1	No	Yes	3	4	2	1
H:H:?3	R:R:N488	29.4	1	Yes	No	0	4	0	1
R:R:G509	R:R:Y510	2.9	0	No	No	9	3	2	1
R:R:F522	R:R:Y510	12.38	0	No	No	1	3	2	1
R:R:N512	R:R:Y514	3.49	1	No	Yes	4	4	1	1
H:H:?3	R:R:N512	14.7	1	Yes	No	0	4	0	1
R:R:V513	R:R:Y514	5.05	1	Yes	Yes	3	4	2	1
H:H:?3	R:R:Y514	11.5	1	Yes	Yes	0	4	0	1
H:H:?3	R:R:Y510	1.05	1	Yes	No	0	3	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	14.16
Average Nodes In Shell	9.00
Average Hubs In Shell	3.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7E6T
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?4	R:R:R205	3.25	30	Yes	No	0	4	0	1
R:R:N207	R:R:N541	13.62	30	No	No	6	5	1	1
R:R:C561	R:R:N207	6.3	0	No	No	9	6	2	1
H:H:?4	R:R:N207	11.02	30	Yes	No	0	6	0	1
R:R:F539	R:R:N541	8.46	30	No	No	1	5	1	1
R:R:F539	R:R:R544	13.9	30	No	No	1	5	1	2
H:H:?4	R:R:F539	5.43	30	Yes	No	0	1	0	1
H:H:?4	R:R:N541	23.27	30	Yes	No	0	5	0	1
R:R:D545	R:R:D578	3.99	0	No	No	5	7	1	2
H:H:?4	R:R:D545	16.95	30	Yes	No	0	5	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	11.98
Average Nodes In Shell	9.00
Average Hubs In Shell	1.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7EVY

Lipid

Lysophospholipid (S1P)

S1P1

Homo sapiens

Siponimod

Gi1/Beta1/Gamma2

2.98

2021-09-29

10.1038/s41422-021-00566-x

A 2D representation of the interactions of NAG in 7EVY
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L35	R:R:N30	2.75	0	No	No	6	9	2	1
H:H:?1	R:R:N30	20.82	0	No	No	0	9	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	20.82
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7F6G

Peptide

Angiotensin

AT1

Homo sapiens

SAR1-AngII

Gq/Beta1/Gamma2

2.9

2023-03-29

10.15252/embj.2022112940

A 2D representation of the interactions of NAG in 7F6G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F171	R:R:N176	3.62	0	No	No	6	5	2	1
H:H:?401	R:R:N176	30.62	0	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	30.62
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7FD8

Aminoacid

Metabotropic glutamate

mGlu5; mGlu5

Homo sapiens

Quisqualate

3.8

2021-09-08

10.1016/j.celrep.2021.109648

A 2D representation of the interactions of NAG in 7FD8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N210	R:R:R508	6.03	0	No	No	4	1	1	2
H:H:?1	R:R:N210	30.62	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	30.62
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7FD8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N210	S:S:R508	6.03	0	No	No	4	1	1	2
H:H:?2	S:S:N210	30.62	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	30.62
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7FD9

Aminoacid

Metabotropic glutamate

mGlu5; mGlu5

Homo sapiens

LY341495

2021-09-08

10.1016/j.celrep.2021.109648

A 2D representation of the interactions of NAG in 7FD9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N210	R:R:R508	15.67	5	No	No	4	1	1	1
H:H:?1	R:R:N210	24.5	5	No	No	0	4	0	1
R:R:R508	R:R:W211	3	5	No	Yes	1	9	1	2
H:H:?1	R:R:R508	3.25	5	No	No	0	1	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.88
Average Nodes In Shell	4.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7FD9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N210	S:S:R508	15.67	8	No	No	4	1	1	1
H:H:?2	S:S:N210	24.5	8	No	No	0	4	0	1
S:S:R508	S:S:W211	3	8	No	Yes	1	9	1	2
H:H:?2	S:S:R508	3.25	8	No	No	0	1	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.88
Average Nodes In Shell	4.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7FIG

Protein

Glycoprotein hormone

Homo sapiens

hCG

chim(NtGi1L-Gs)/Beta1/Gamma2

3.9

2021-09-29

10.1038/s41586-021-03924-2

A 2D representation of the interactions of NAG in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N174	R:R:S147	5.96	27	No	No	4	5	1	1
H:H:?1	R:R:S147	12.05	27	No	No	0	5	0	1
H:H:?1	R:R:N174	29.4	27	No	No	0	4	0	1
R:R:N173	R:R:N174	1.36	0	Yes	No	4	4	2	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	20.73
Average Nodes In Shell	4.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:?166	R:R:N167	9.58	0	Yes	No	4	7	2	1
R:R:N167	R:R:N195	13.62	15	No	Yes	7	5	1	1
H:H:?2	R:R:N167	19.6	15	Yes	No	0	7	0	1
R:R:?171	R:R:Q170	6.96	0	No	Yes	4	3	2	1
R:R:N195	R:R:Q170	13.2	15	Yes	Yes	5	3	1	1
R:R:?196	R:R:Q170	8.13	15	No	Yes	6	3	2	1
H:H:?2	R:R:Q170	16.62	15	Yes	Yes	0	3	0	1
R:R:H192	R:R:S191	4.18	0	Yes	No	5	5	1	2
R:R:H192	R:R:R219	9.03	0	Yes	No	5	1	1	2
R:R:?220	R:R:H192	4.48	0	No	Yes	5	5	2	1
H:H:?2	R:R:H192	8.03	15	Yes	Yes	0	5	0	1
R:R:?196	R:R:N195	8.38	15	No	Yes	6	5	2	1
R:R:?220	R:R:N195	10.78	0	No	Yes	5	5	2	1
H:H:?2	R:R:N195	24.5	15	Yes	Yes	0	5	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	17.19
Average Nodes In Shell	11.00
Average Hubs In Shell	5.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	14.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
L:L:N76	L:L:V77	4.43	No	Yes	1	2
L:L:N76	M:M:T117	5.85	No	No	1	2
H:H:?3	L:L:N76	25.72	No	No	0	1
M:M:A103	M:M:V82	5.09	No	No	1	2
M:M:A103	M:M:F84	4.16	No	No	1	2
H:H:?3	M:M:A103	4.22	No	No	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.97
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
L:L:L36	L:L:L50	11.07	No	No	2	1
H:H:?4	L:L:P48	7.32	No	No	0	1
L:L:I49	L:L:N102	4.25	Yes	No	2	1
H:H:?4	L:L:L50	7.41	No	No	0	1
H:H:?4	L:L:N102	23.27	No	No	0	1
L:L:N102	L:L:V92	2.96	No	No	1	2
L:L:?46	L:L:P48	2.86	No	No	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	12.67
Average Nodes In Shell	8.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7FIG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
H:H:?5	M:M:N33	26.95	No	No	0	1
M:M:N50	M:M:T35	4.39	No	No	1	2
M:M:N33	M:M:T52	1.46	No	No	1	2
H:H:?5	M:M:N50	1.22	No	No	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.08
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7M3E

Ion

Calcium-sensing

CaS

Homo sapiens

Ca; Ca; Tryptophan; NPS-2143; PO4

3.2

2021-06-30

10.1038/s41586-021-03691-0

A 2D representation of the interactions of NAG in 7M3E
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:R205	8.67	5	Yes	No	0	4	0	1
H:H:?2	R:R:R205	16.25	5	No	No	0	4	1	1
R:R:N207	R:R:N541	9.54	5	No	No	6	5	1	1
R:R:C561	R:R:N207	7.87	5	No	No	9	6	2	1
H:H:?1	R:R:N207	9.8	5	Yes	No	0	6	0	1
R:R:F539	R:R:N541	6.04	5	Yes	No	1	5	1	1
R:R:F539	R:R:R544	19.24	5	Yes	No	1	5	1	2
H:H:?1	R:R:F539	6.52	5	Yes	Yes	0	1	0	1
H:H:?1	R:R:N541	28.17	5	Yes	No	0	5	0	1
R:R:D545	R:R:D578	6.65	0	No	No	5	7	1	2
H:H:?1	R:R:D545	8.47	5	Yes	No	0	5	0	1
H:H:?1	H:H:?2	30.84	5	Yes	No	0	0	0	1
R:R:F539	R:R:K265	1.24	5	Yes	No	1	5	1	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	15.41
Average Nodes In Shell	11.00
Average Hubs In Shell	2.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3E
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:R205	8.67	5	Yes	No	0	4	1	1
H:H:?2	R:R:R205	16.25	5	No	No	0	4	0	1
R:R:N207	R:R:N541	9.54	5	No	No	6	5	2	2
H:H:?1	R:R:N207	9.8	5	Yes	No	0	6	1	2
R:R:F539	R:R:N541	6.04	5	Yes	No	1	5	2	2
H:H:?1	R:R:F539	6.52	5	Yes	Yes	0	1	1	2
H:H:?1	R:R:N541	28.17	5	Yes	No	0	5	1	2
H:H:?1	R:R:D545	8.47	5	Yes	No	0	5	1	2
H:H:?1	H:H:?2	30.84	5	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	23.55
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3E
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F239	R:R:V258	3.93	5	Yes	Yes	6	4	2	1
R:R:E241	R:R:H254	3.69	5	No	No	5	3	2	2
R:R:E241	R:R:V258	11.41	5	No	Yes	5	4	2	1
R:R:H254	R:R:V258	5.54	5	No	Yes	3	4	2	1
H:H:?3	R:R:V258	2.66	0	No	Yes	0	4	0	1
H:H:?3	R:R:N261	24.5	0	No	No	0	4	0	1
H:H:?3	R:R:E257	2.36	0	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	9.84
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3E
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N287	R:R:T289	2.92	0	No	No	6	5	1	2
R:R:H312	R:R:N287	5.1	39	No	No	3	6	2	1
H:H:?4	R:R:N287	26.95	0	No	No	0	6	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	26.95
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3E
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E475	R:R:K323	5.4	0	No	No	5	5	2	1
H:H:?5	R:R:K323	3.77	28	Yes	No	0	5	0	1
R:R:V486	R:R:Y514	5.05	0	No	Yes	3	4	2	1
R:R:N488	R:R:N512	6.81	28	No	Yes	4	4	1	1
R:R:N488	R:R:Y514	4.65	28	No	Yes	4	4	1	1
H:H:?5	R:R:N488	23.27	28	Yes	No	0	4	0	1
R:R:F522	R:R:Y510	18.57	0	No	No	1	3	2	1
H:H:?5	R:R:Y510	8.37	28	Yes	No	0	3	0	1
R:R:N512	R:R:Y514	3.49	28	Yes	Yes	4	4	1	1
R:R:A515	R:R:N512	3.13	0	No	Yes	4	4	2	1
H:H:?5	R:R:N512	15.92	28	Yes	Yes	0	4	0	1
R:R:V513	R:R:Y514	6.31	0	No	Yes	3	4	2	1
H:H:?5	R:R:Y514	9.41	28	Yes	Yes	0	4	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	12.15
Average Nodes In Shell	11.00
Average Hubs In Shell	3.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3E
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N468	R:R:Q476	6.6	43	No	No	6	3	1	1
R:R:N468	R:R:T478	7.31	43	No	No	6	3	1	2
H:H:?6	R:R:N468	29.4	43	No	No	0	6	0	1
R:R:Q476	R:R:T470	5.67	43	No	No	3	5	1	2
H:H:?6	R:R:Q476	10.69	43	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	20.04
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3E
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?7	S:S:R205	16.25	3	Yes	No	0	4	0	1
S:S:N207	S:S:N541	8.17	3	No	No	6	5	1	1
S:S:C561	S:S:N207	4.72	3	Yes	No	9	6	2	1
H:H:?7	S:S:N207	14.7	3	Yes	No	0	6	0	1
S:S:F539	S:S:N541	6.04	3	No	No	1	5	1	1
S:S:F539	S:S:R544	21.38	3	No	No	1	5	1	2
H:H:?7	S:S:F539	6.52	3	Yes	No	0	1	0	1
H:H:?7	S:S:N541	25.72	3	Yes	No	0	5	0	1
S:S:D545	S:S:T577	4.34	3	No	No	5	5	1	2
S:S:D545	S:S:D578	14.64	3	No	Yes	5	7	1	2
H:H:?7	S:S:D545	10.9	3	Yes	No	0	5	0	1
S:S:D578	S:S:T577	4.34	3	Yes	No	7	5	2	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.82
Average Nodes In Shell	10.00
Average Hubs In Shell	3.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3E
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:F239	S:S:V258	3.93	3	Yes	Yes	6	4	2	1
S:S:E241	S:S:H254	3.69	3	No	No	5	3	2	2
S:S:E241	S:S:V258	8.56	3	No	Yes	5	4	2	1
S:S:H254	S:S:V258	4.15	3	No	Yes	3	4	2	1
H:H:?8	S:S:E257	3.55	0	No	No	0	3	0	1
H:H:?8	S:S:V258	3.99	0	No	Yes	0	4	0	1
H:H:?8	S:S:N261	25.72	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	11.09
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3E
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N287	S:S:T289	2.92	4	No	No	6	5	1	1
S:S:H312	S:S:N287	6.38	4	No	No	3	6	2	1
H:H:?9	S:S:N287	25.72	4	No	No	0	6	0	1
H:H:?9	S:S:T289	2.63	4	No	No	0	5	0	1
S:S:G290	S:S:T289	1.82	0	No	No	4	5	2	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.17
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3E
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?10	S:S:K323	5.03	15	Yes	No	0	5	0	1
S:S:V486	S:S:V513	3.21	15	No	Yes	3	3	2	2
S:S:V486	S:S:Y514	3.79	15	No	Yes	3	4	2	1
S:S:N488	S:S:N512	5.45	15	No	Yes	4	4	1	1
S:S:N488	S:S:V513	2.96	15	No	Yes	4	3	1	2
H:H:?10	S:S:N488	23.27	15	Yes	No	0	4	0	1
S:S:F522	S:S:Y510	16.5	0	No	No	1	3	2	1
H:H:?10	S:S:Y510	7.32	15	Yes	No	0	3	0	1
S:S:N512	S:S:Y514	3.49	15	Yes	Yes	4	4	1	1
S:S:A515	S:S:N512	3.13	0	No	Yes	4	4	2	1
H:H:?10	S:S:N512	14.7	15	Yes	Yes	0	4	0	1
S:S:V513	S:S:Y514	5.05	15	Yes	Yes	3	4	2	1
H:H:?10	S:S:Y514	10.46	15	Yes	Yes	0	4	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	12.16
Average Nodes In Shell	10.00
Average Hubs In Shell	4.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3E
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N468	S:S:Q476	6.6	33	No	No	6	3	1	1
S:S:N468	S:S:T478	5.85	33	No	No	6	3	1	1
H:H:?11	S:S:N468	23.27	33	No	No	0	6	0	1
S:S:Q476	S:S:T470	7.09	33	No	No	3	5	1	2
H:H:?11	S:S:Q476	3.56	33	No	No	0	3	0	1
H:H:?11	S:S:T478	6.57	33	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	11.13
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7M3F

Ion

Calcium-sensing

CaS

Homo sapiens

Ca; Ca; Tryptophan; Cinacalcet; PO4

2.8

2021-06-30

10.1038/s41586-021-03691-0

A 2D representation of the interactions of NAG in 7M3F
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E475	R:R:K323	4.05	2	No	No	5	5	1	1
H:H:?1	R:R:K323	5.03	2	Yes	No	0	5	0	1
R:R:E475	R:R:N471	3.94	2	No	Yes	5	6	1	2
H:H:?1	R:R:E475	3.55	2	Yes	No	0	5	0	1
R:R:V486	R:R:V513	3.21	2	No	Yes	3	3	2	2
R:R:V486	R:R:Y514	3.79	2	No	Yes	3	4	2	1
R:R:N488	R:R:N512	6.81	2	No	Yes	4	4	1	1
R:R:N488	R:R:Y514	4.65	2	No	Yes	4	4	1	1
H:H:?1	R:R:N488	26.95	2	Yes	No	0	4	0	1
R:R:F522	R:R:Y510	16.5	0	No	No	1	3	2	1
H:H:?1	R:R:Y510	7.32	2	Yes	No	0	3	0	1
R:R:N512	R:R:Y514	3.49	2	Yes	Yes	4	4	1	1
R:R:A515	R:R:N512	3.13	0	No	Yes	4	4	2	1
H:H:?1	R:R:N512	17.15	2	Yes	Yes	0	4	0	1
R:R:V513	R:R:Y514	5.05	2	Yes	Yes	3	4	2	1
H:H:?1	R:R:Y514	8.37	2	Yes	Yes	0	4	0	1
H:H:?1	H:H:?2	34.14	2	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	14.64
Average Nodes In Shell	13.00
Average Hubs In Shell	5.00
Average Links In Shell	17.00
Average Links Mediated by Hubs In Shell	15.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3F
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E475	R:R:K323	4.05	2	No	No	5	5	2	2
H:H:?1	R:R:K323	5.03	2	Yes	No	0	5	1	2
H:H:?1	R:R:E475	3.55	2	Yes	No	0	5	1	2
R:R:N488	R:R:N512	6.81	2	No	Yes	4	4	2	2
R:R:N488	R:R:Y514	4.65	2	No	Yes	4	4	2	2
H:H:?1	R:R:N488	26.95	2	Yes	No	0	4	1	2
H:H:?1	R:R:Y510	7.32	2	Yes	No	0	3	1	2
R:R:N512	R:R:Y514	3.49	2	Yes	Yes	4	4	2	2
H:H:?1	R:R:N512	17.15	2	Yes	Yes	0	4	1	2
H:H:?1	R:R:Y514	8.37	2	Yes	Yes	0	4	1	2
H:H:?1	H:H:?2	34.14	2	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	34.14
Average Nodes In Shell	8.00
Average Hubs In Shell	3.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3F
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R205	4.33	3	Yes	No	0	4	0	1
H:H:?4	R:R:R205	14.09	3	No	No	0	4	1	1
R:R:N207	R:R:N541	16.35	3	No	No	6	5	1	1
R:R:C561	R:R:N207	7.87	3	No	No	9	6	2	1
H:H:?3	R:R:N207	11.02	3	Yes	No	0	6	0	1
R:R:F539	R:R:N541	7.25	3	No	No	1	5	1	1
R:R:F539	R:R:R544	21.38	3	No	No	1	5	1	2
H:H:?3	R:R:F539	5.43	3	Yes	No	0	1	0	1
H:H:?3	R:R:N541	25.72	3	Yes	No	0	5	0	1
R:R:D545	R:R:T577	4.34	0	No	No	5	5	1	2
R:R:D545	R:R:D578	10.65	0	No	No	5	7	1	2
H:H:?3	R:R:D545	9.68	3	Yes	No	0	5	0	1
H:H:?3	H:H:?4	34.14	3	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.05
Average Nodes In Shell	11.00
Average Hubs In Shell	1.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3F
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R205	4.33	3	Yes	No	0	4	1	1
H:H:?4	R:R:R205	14.09	3	No	No	0	4	0	1
R:R:N207	R:R:N541	16.35	3	No	No	6	5	2	2
H:H:?3	R:R:N207	11.02	3	Yes	No	0	6	1	2
R:R:F539	R:R:N541	7.25	3	No	No	1	5	2	2
H:H:?3	R:R:F539	5.43	3	Yes	No	0	1	1	2
H:H:?3	R:R:N541	25.72	3	Yes	No	0	5	1	2
H:H:?3	R:R:D545	9.68	3	Yes	No	0	5	1	2
H:H:?3	H:H:?4	34.14	3	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	24.12
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3F
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?5	S:S:R205	14.09	15	Yes	No	0	4	0	1
H:H:?6	S:S:R205	18.42	15	No	No	0	4	1	1
S:S:N207	S:S:N541	17.71	15	No	No	6	5	1	1
S:S:C561	S:S:N207	9.45	0	No	No	9	6	2	1
H:H:?5	S:S:N207	8.57	15	Yes	No	0	6	0	1
S:S:F539	S:S:N541	4.83	15	No	No	1	5	1	1
S:S:F539	S:S:R544	23.52	15	No	No	1	5	1	2
H:H:?5	S:S:F539	5.43	15	Yes	No	0	1	0	1
H:H:?5	S:S:N541	26.95	15	Yes	No	0	5	0	1
S:S:D545	S:S:D578	15.97	0	No	No	5	7	1	2
H:H:?5	S:S:D545	8.47	15	Yes	No	0	5	0	1
H:H:?5	H:H:?6	30.84	15	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.72
Average Nodes In Shell	10.00
Average Hubs In Shell	1.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3F
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?5	S:S:R205	14.09	15	Yes	No	0	4	1	1
H:H:?6	S:S:R205	18.42	15	No	No	0	4	0	1
S:S:N207	S:S:N541	17.71	15	No	No	6	5	2	2
H:H:?5	S:S:N207	8.57	15	Yes	No	0	6	1	2
S:S:F539	S:S:N541	4.83	15	No	No	1	5	2	2
H:H:?5	S:S:F539	5.43	15	Yes	No	0	1	1	2
H:H:?5	S:S:N541	26.95	15	Yes	No	0	5	1	2
H:H:?5	S:S:D545	8.47	15	Yes	No	0	5	1	2
H:H:?5	H:H:?6	30.84	15	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	24.63
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3F
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E241	R:R:H254	3.69	3	No	No	5	3	2	1
R:R:E241	R:R:V258	8.56	3	No	No	5	4	2	2
R:R:H254	R:R:V258	5.54	3	No	No	3	4	1	2
H:H:?7	R:R:E257	5.91	0	No	No	0	3	0	1
H:H:?7	R:R:N261	26.95	0	No	No	0	4	0	1
H:H:?7	R:R:H254	2.29	0	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	11.72
Average Nodes In Shell	6.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3F
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H312	R:R:V284	2.77	28	No	No	3	3	1	2
R:R:V284	R:R:V313	6.41	28	No	Yes	3	3	2	2
H:H:?8	R:R:N287	28.17	0	No	No	0	6	0	1
R:R:H312	R:R:V313	2.77	28	No	Yes	3	3	1	2
H:H:?8	R:R:H312	4.59	0	No	No	0	3	0	1
R:R:G290	R:R:T289	1.82	0	No	No	4	5	2	1
H:H:?8	R:R:T289	1.31	0	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	11.36
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	2.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3F
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N468	R:R:Q476	7.92	32	No	No	6	3	1	1
R:R:N468	R:R:T478	5.85	32	No	No	6	3	1	2
H:H:?9	R:R:N468	25.72	32	No	No	0	6	0	1
R:R:Q476	R:R:T470	7.09	32	No	No	3	5	1	2
H:H:?9	R:R:Q476	7.12	32	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	16.42
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3F
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E593	R:R:N592	18.4	21	No	No	2	7	1	2
R:R:N592	R:R:N594	5.45	21	No	Yes	7	3	2	1
R:R:E593	R:R:N594	2.63	21	No	Yes	2	3	1	1
H:H:?10	R:R:E593	7.09	21	No	No	0	2	0	1
R:R:N594	R:R:T596	2.92	21	Yes	No	3	5	1	2
H:H:?10	R:R:N594	31.85	21	No	Yes	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	19.47
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3F
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:E241	S:S:H254	4.92	1	No	No	5	3	2	1
S:S:E241	S:S:V258	8.56	1	No	No	5	4	2	2
S:S:H254	S:S:V258	5.54	1	No	No	3	4	1	2
H:H:?11	S:S:E257	7.09	0	No	No	0	3	0	1
H:H:?11	S:S:N261	24.5	0	No	No	0	4	0	1
H:H:?11	S:S:H254	2.29	0	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	11.29
Average Nodes In Shell	6.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3F
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:H312	S:S:V284	2.77	12	Yes	No	3	3	1	2
S:S:V284	S:S:V313	6.41	12	No	Yes	3	3	2	2
S:S:H312	S:S:N287	6.38	12	Yes	No	3	6	1	1
H:H:?12	S:S:N287	29.4	12	No	No	0	6	0	1
S:S:H312	S:S:V313	2.77	12	Yes	Yes	3	3	1	2
H:H:?12	S:S:H312	3.44	12	No	Yes	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	16.42
Average Nodes In Shell	5.00
Average Hubs In Shell	2.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3F
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?13	S:S:K323	3.77	16	Yes	No	0	5	0	1
S:S:V486	S:S:Y514	3.79	0	No	Yes	3	4	2	1
S:S:N488	S:S:N512	5.45	16	Yes	Yes	4	4	1	1
S:S:N488	S:S:V513	2.96	16	Yes	Yes	4	3	1	2
S:S:N488	S:S:Y514	3.49	16	Yes	Yes	4	4	1	1
H:H:?13	S:S:N488	25.72	16	Yes	Yes	0	4	0	1
S:S:F522	S:S:Y510	15.47	0	No	No	1	3	2	1
H:H:?13	S:S:Y510	8.37	16	Yes	No	0	3	0	1
S:S:N512	S:S:Y514	3.49	16	Yes	Yes	4	4	1	1
S:S:A515	S:S:N512	3.13	0	No	Yes	4	4	2	1
H:H:?13	S:S:N512	13.47	16	Yes	Yes	0	4	0	1
S:S:V513	S:S:Y514	5.05	16	Yes	Yes	3	4	2	1
H:H:?13	S:S:Y514	11.5	16	Yes	Yes	0	4	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	12.57
Average Nodes In Shell	10.00
Average Hubs In Shell	5.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3F
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N468	S:S:Q476	6.6	23	No	No	6	3	1	1
S:S:N468	S:S:T478	8.77	23	No	No	6	3	1	1
H:H:?14	S:S:N468	23.27	23	No	No	0	6	0	1
S:S:Q476	S:S:T470	8.5	23	No	No	3	5	1	2
H:H:?14	S:S:Q476	8.31	23	No	No	0	3	0	1
H:H:?14	S:S:T478	3.94	23	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	11.84
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3F
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N592	S:S:N594	2.72	0	No	No	7	3	2	1
S:S:N594	S:S:T596	2.92	48	No	Yes	3	5	1	1
H:H:?15	S:S:N594	25.72	48	No	No	0	3	0	1
H:H:?15	S:S:T596	3.94	48	No	Yes	0	5	0	1
S:S:A548	S:S:T596	1.68	0	No	Yes	4	5	2	1
S:S:S597	S:S:T596	1.6	0	No	Yes	1	5	2	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	14.83
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7M3G

Ion

Calcium-sensing

CaS

Homo sapiens

Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4

2.5

2021-06-30

10.1038/s41586-021-03691-0

A 2D representation of the interactions of NAG in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E257	R:R:V256	2.85	27	No	No	3	5	1	2
R:R:R286	R:R:V256	6.54	27	Yes	No	4	5	2	2
R:R:E257	R:R:R286	10.47	27	No	Yes	3	4	1	2
H:H:?1	R:R:N261	28.17	0	No	No	0	4	0	1
H:H:?1	H:H:?2	30.84	0	No	No	0	0	0	1
H:H:?1	R:R:E257	2.36	0	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	20.46
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	2.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:N261	28.17	No	No	4	1	2
H:H:?1	H:H:?2	30.84	No	No	0	1	0
H:H:?1	R:R:E257	2.36	No	No	3	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	30.84
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R205	6.5	15	Yes	No	0	4	0	1
H:H:?4	R:R:R205	16.25	15	No	No	0	4	1	1
R:R:N207	R:R:N541	16.35	15	No	No	6	5	1	1
R:R:C561	R:R:N207	9.45	0	No	No	9	6	2	1
H:H:?3	R:R:N207	14.7	15	Yes	No	0	6	0	1
R:R:F539	R:R:N541	4.83	15	No	No	1	5	1	1
R:R:F539	R:R:R544	24.59	15	No	No	1	5	1	2
H:H:?3	R:R:F539	5.43	15	Yes	No	0	1	0	1
H:H:?3	R:R:N541	26.95	15	Yes	No	0	5	0	1
R:R:D545	R:R:T577	4.34	15	No	No	5	5	1	2
R:R:D545	R:R:D578	13.31	15	No	No	5	7	1	2
H:H:?3	R:R:D545	8.47	15	Yes	No	0	5	0	1
R:R:D578	R:R:T577	2.89	15	No	No	7	5	2	2
H:H:?3	H:H:?4	35.24	15	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	16.21
Average Nodes In Shell	11.00
Average Hubs In Shell	1.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R205	6.5	15	Yes	No	0	4	1	1
H:H:?4	R:R:R205	16.25	15	No	No	0	4	0	1
R:R:N207	R:R:N541	16.35	15	No	No	6	5	2	2
H:H:?3	R:R:N207	14.7	15	Yes	No	0	6	1	2
R:R:F539	R:R:N541	4.83	15	No	No	1	5	2	2
H:H:?3	R:R:F539	5.43	15	Yes	No	0	1	1	2
H:H:?3	R:R:N541	26.95	15	Yes	No	0	5	1	2
H:H:?3	R:R:D545	8.47	15	Yes	No	0	5	1	2
H:H:?3	H:H:?4	35.24	15	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	25.75
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:H254	S:S:V258	4.15	No	No	3	4	1	2
S:S:H254	W:W:?4	8.22	No	Yes	3	0	1	2
H:H:?5	S:S:E257	4.73	Yes	No	0	3	0	1
H:H:?5	S:S:N261	29.4	Yes	No	0	4	0	1
H:H:?5	H:H:?6	34.14	Yes	No	0	0	0	1
H:H:?5	S:S:H254	2.29	Yes	No	0	3	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	17.64
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?5	S:S:E257	4.73	Yes	No	3	1	2
H:H:?5	S:S:N261	29.4	Yes	No	4	1	2
H:H:?5	H:H:?6	34.14	Yes	No	0	1	0
H:H:?5	S:S:H254	2.29	Yes	No	3	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	34.14
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?7	S:S:K323	6.29	34	Yes	No	0	5	0	1
S:S:V486	S:S:Y514	3.79	0	No	Yes	3	4	2	1
S:S:N488	S:S:N512	6.81	34	No	Yes	4	4	1	1
S:S:N488	S:S:Y514	4.65	34	No	Yes	4	4	1	1
H:H:?7	S:S:N488	25.72	34	Yes	No	0	4	0	1
S:S:F522	S:S:Y510	15.47	0	No	No	1	3	2	1
H:H:?7	S:S:Y510	11.5	34	Yes	No	0	3	0	1
S:S:N512	S:S:Y514	3.49	34	Yes	Yes	4	4	1	1
S:S:A515	S:S:N512	4.69	0	No	Yes	4	4	2	1
H:H:?7	S:S:N512	17.15	34	Yes	Yes	0	4	0	1
S:S:V513	S:S:Y514	5.05	0	No	Yes	3	4	2	1
H:H:?7	S:S:Y514	7.32	34	Yes	Yes	0	4	0	1
H:H:?7	H:H:?8	38.55	34	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	17.75
Average Nodes In Shell	11.00
Average Hubs In Shell	3.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?7	S:S:K323	6.29	34	Yes	No	0	5	1	2
S:S:N488	S:S:N512	6.81	34	No	Yes	4	4	2	2
S:S:N488	S:S:Y514	4.65	34	No	Yes	4	4	2	2
H:H:?7	S:S:N488	25.72	34	Yes	No	0	4	1	2
H:H:?7	S:S:Y510	11.5	34	Yes	No	0	3	1	2
S:S:N512	S:S:Y514	3.49	34	Yes	Yes	4	4	2	2
H:H:?7	S:S:N512	17.15	34	Yes	Yes	0	4	1	2
H:H:?7	S:S:Y514	7.32	34	Yes	Yes	0	4	1	2
H:H:?7	H:H:?8	38.55	34	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	38.55
Average Nodes In Shell	7.00
Average Hubs In Shell	3.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?9	S:S:R205	6.5	23	Yes	No	0	4	0	1
H:H:?10	S:S:R205	16.25	23	No	No	0	4	1	1
S:S:N207	S:S:N541	14.98	23	No	No	6	5	1	1
S:S:C561	S:S:N207	7.87	0	No	No	9	6	2	1
H:H:?9	S:S:N207	11.02	23	Yes	No	0	6	0	1
S:S:F539	S:S:N541	6.04	23	No	No	1	5	1	1
S:S:F539	S:S:R544	21.38	23	No	No	1	5	1	2
H:H:?9	S:S:F539	5.43	23	Yes	No	0	1	0	1
H:H:?9	S:S:N541	23.27	23	Yes	No	0	5	0	1
S:S:D545	S:S:D578	10.65	0	No	No	5	7	1	2
H:H:?9	S:S:D545	8.47	23	Yes	No	0	5	0	1
H:H:?10	H:H:?9	35.24	23	No	Yes	0	0	1	0

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.99
Average Nodes In Shell	10.00
Average Hubs In Shell	1.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?9	S:S:R205	6.5	23	Yes	No	0	4	1	1
H:H:?10	S:S:R205	16.25	23	No	No	0	4	0	1
S:S:N207	S:S:N541	14.98	23	No	No	6	5	2	2
H:H:?9	S:S:N207	11.02	23	Yes	No	0	6	1	2
S:S:F539	S:S:N541	6.04	23	No	No	1	5	2	2
H:H:?9	S:S:F539	5.43	23	Yes	No	0	1	1	2
H:H:?9	S:S:N541	23.27	23	Yes	No	0	5	1	2
H:H:?9	S:S:D545	8.47	23	Yes	No	0	5	1	2
H:H:?10	H:H:?9	35.24	23	No	Yes	0	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	25.75
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N468	R:R:Q476	7.92	31	No	No	6	3	1	1
R:R:N468	R:R:T478	5.85	31	No	No	6	3	1	1
H:H:?11	R:R:N468	23.27	31	No	No	0	6	0	1
R:R:Q476	R:R:T470	8.5	31	No	No	3	5	1	2
H:H:?11	R:R:Q476	3.56	31	No	No	0	3	0	1
H:H:?11	R:R:T478	6.57	31	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	11.13
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?12	R:R:K323	5.03	26	Yes	No	0	5	0	1
R:R:V486	R:R:Y514	3.79	0	No	Yes	3	4	2	1
R:R:N488	R:R:N512	6.81	26	Yes	Yes	4	4	1	1
R:R:N488	R:R:V513	2.96	26	Yes	Yes	4	3	1	2
R:R:N488	R:R:Y514	5.81	26	Yes	Yes	4	4	1	1
H:H:?12	R:R:N488	24.5	26	Yes	Yes	0	4	0	1
R:R:F522	R:R:Y510	16.5	0	No	No	1	3	2	1
H:H:?12	R:R:Y510	11.5	26	Yes	No	0	3	0	1
R:R:N512	R:R:Y514	4.65	26	Yes	Yes	4	4	1	1
R:R:A515	R:R:N512	3.13	0	No	Yes	4	4	2	1
H:H:?12	R:R:N512	15.92	26	Yes	Yes	0	4	0	1
R:R:V513	R:R:Y514	5.05	26	Yes	Yes	3	4	2	1
H:H:?12	R:R:Y514	12.55	26	Yes	Yes	0	4	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	13.90
Average Nodes In Shell	10.00
Average Hubs In Shell	5.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?13	R:R:N594	26.95	No	No	0	3	0	1
R:R:N594	R:R:T596	1.46	No	No	3	5	1	2
H:H:?13	R:R:E593	1.18	No	No	0	2	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.06
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N468	S:S:Q476	6.6	35	No	No	6	3	1	1
S:S:N468	S:S:T478	5.85	35	No	No	6	3	1	1
H:H:?14	S:S:N468	24.5	35	No	No	0	6	0	1
S:S:Q476	S:S:T470	5.67	35	No	No	3	5	1	2
H:H:?14	S:S:Q476	7.12	35	No	No	0	3	0	1
H:H:?14	S:S:T478	6.57	35	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	12.73
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:E593	S:S:N592	3.94	54	No	Yes	2	7	1	2
S:S:N592	S:S:T596	2.92	0	Yes	No	7	5	2	1
S:S:E593	S:S:N594	6.57	54	No	No	2	3	1	1
H:H:?15	S:S:E593	7.09	54	No	No	0	2	0	1
H:H:?15	S:S:N594	26.95	54	No	No	0	3	0	1
H:H:?15	S:S:T596	5.26	54	No	No	0	5	0	1
S:S:A548	S:S:T596	1.68	0	No	No	4	5	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.10
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	2.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7M3J

Ion

Calcium-sensing

CaS

Homo sapiens

NPS-2143; PO4

4.1

2021-06-30

10.1038/s41586-021-03691-0

A 2D representation of the interactions of NAG in 7M3J
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:R205	2.17	20	Yes	No	0	4	0	1
H:H:?2	R:R:R205	15.17	20	No	No	0	4	1	1
R:R:N207	R:R:N541	19.07	20	No	No	6	5	1	1
H:H:?1	R:R:N207	29.4	20	Yes	No	0	6	0	1
R:R:F539	R:R:N541	6.04	0	No	No	1	5	2	1
H:H:?1	R:R:N541	33.07	20	Yes	No	0	5	0	1
H:H:?1	H:H:?2	46.25	20	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	27.72
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3J
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:R205	2.17	20	Yes	No	0	4	1	1
H:H:?2	R:R:R205	15.17	20	No	No	0	4	0	1
R:R:N207	R:R:N541	19.07	20	No	No	6	5	2	2
H:H:?1	R:R:N207	29.4	20	Yes	No	0	6	1	2
H:H:?1	R:R:N541	33.07	20	Yes	No	0	5	1	2
H:H:?1	H:H:?2	46.25	20	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	30.71
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3J
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E257	R:R:Q253	3.82	1	No	No	3	3	1	2
R:R:Q253	R:R:R286	8.18	1	No	Yes	3	4	2	2
R:R:E257	R:R:R286	4.65	1	No	Yes	3	4	1	2
H:H:?3	R:R:E257	13	0	No	No	0	3	0	1
H:H:?3	R:R:N261	26.95	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	19.98
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	2.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3J
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N468	R:R:Q476	3.96	37	No	No	6	3	1	1
H:H:?4	R:R:N468	30.62	37	No	No	0	6	0	1
R:R:Q476	R:R:T470	8.5	37	No	No	3	5	1	2
H:H:?4	R:R:Q476	8.31	37	No	No	0	3	0	1
H:H:?4	R:R:T478	3.94	37	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.29
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3J
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K323	R:R:N488	2.8	0	No	No	5	4	2	1
R:R:G487	R:R:V486	1.84	14	No	No	6	3	1	2
R:R:V486	R:R:V513	3.21	14	No	Yes	3	3	2	2
R:R:G487	R:R:V513	1.84	14	No	Yes	6	3	1	2
H:H:?5	R:R:G487	1.53	14	Yes	No	0	6	0	1
H:H:?5	R:R:N488	28.17	14	Yes	No	0	4	0	1
R:R:N512	R:R:Y510	8.14	14	No	No	4	3	1	1
R:R:F522	R:R:Y510	12.38	0	No	No	1	3	2	1
H:H:?5	R:R:Y510	2.09	14	Yes	No	0	3	0	1
R:R:A515	R:R:N512	1.56	0	No	No	4	4	2	1
H:H:?5	R:R:N512	6.12	14	Yes	No	0	4	0	1
H:H:?5	R:R:Y514	3.14	14	Yes	No	0	4	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	8.21
Average Nodes In Shell	11.00
Average Hubs In Shell	2.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3J
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?6	S:S:R205	2.17	4	Yes	No	0	4	0	1
S:S:C236	S:S:N207	1.57	4	No	Yes	9	6	2	1
S:S:N207	S:S:N541	12.26	4	Yes	No	6	5	1	1
S:S:C561	S:S:N207	1.57	4	Yes	Yes	9	6	2	1
H:H:?6	S:S:N207	11.02	4	Yes	Yes	0	6	0	1
S:S:C236	S:S:C561	7.28	4	No	Yes	9	9	2	2
S:S:E536	S:S:F539	4.66	0	No	No	5	1	2	1
S:S:F539	S:S:R544	2.14	0	No	No	1	5	1	2
H:H:?6	S:S:F539	2.17	4	Yes	No	0	1	0	1
H:H:?6	S:S:N541	30.62	4	Yes	No	0	5	0	1
S:S:D545	S:S:D578	7.98	0	No	No	5	7	1	2
H:H:?6	S:S:D545	3.63	4	Yes	No	0	5	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	9.92
Average Nodes In Shell	11.00
Average Hubs In Shell	3.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7M3J
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N488	S:S:N512	4.09	51	No	No	4	4	1	1
H:H:?7	S:S:N488	31.85	51	No	No	0	4	0	1
S:S:S490	S:S:Y510	2.54	4	No	Yes	8	3	2	1
S:S:E507	S:S:Y510	11.22	0	No	Yes	5	3	2	1
S:S:G509	S:S:Y510	2.9	23	No	Yes	9	3	2	1
S:S:F522	S:S:Y510	6.19	0	No	Yes	1	3	2	1
H:H:?7	S:S:Y510	3.14	51	No	Yes	0	3	0	1
S:S:A515	S:S:N512	3.13	0	No	No	4	4	2	1
H:H:?7	S:S:N512	11.02	51	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	15.34
Average Nodes In Shell	9.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7MTQ

Aminoacid

Metabotropic glutamate

mGlu2; mGlu2

Homo sapiens

LY341495

3.65

2021-07-07

10.1038/s41586-021-03680-3

A 2D representation of the interactions of NAG in 7MTQ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N203	R:R:R200	6.03	No	No	4	4	1	2
H:H:?1	R:R:N203	29.4	No	No	0	4	0	1
H:H:?1	R:R:L495	3.7	No	No	0	4	0	1
R:R:L495	R:R:P496	1.64	No	No	4	8	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	16.55
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7MTQ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?2	S:S:N203	29.4	No	No	0	4	0	1
H:H:?2	S:S:L495	3.7	No	No	0	4	0	1
S:S:L495	S:S:P496	1.64	No	No	4	8	1	2
S:S:A488	S:S:L495	1.58	No	No	1	4	2	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	16.55
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7MTR

Aminoacid

Metabotropic glutamate

mGlu2; mGlu2

Homo sapiens

Glutamate

ADX55164

3.3

2021-07-07

10.1038/s41586-021-03680-3

A 2D representation of the interactions of NAG in 7MTR
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	S:S:N203	29.4	0	No	No	0	4	0	1
S:S:L495	S:S:W487	2.28	17	No	Yes	4	7	1	2
S:S:P496	S:S:W487	2.7	17	No	Yes	8	7	2	2
S:S:L495	S:S:P496	3.28	17	No	No	4	8	1	2
H:H:?1	S:S:L495	1.23	0	No	No	0	4	0	1
S:S:N203	S:S:R200	1.21	0	No	No	4	4	1	2
S:S:N203	S:S:R499	1.21	0	No	No	4	5	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.31
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	2.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7MTR
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N203	R:R:R200	3.62	0	No	No	4	4	1	2
R:R:F201	R:R:F202	9.65	0	No	Yes	5	8	1	2
R:R:F201	R:R:T482	2.59	0	No	No	5	3	1	2
H:H:?2	R:R:F201	2.17	0	No	No	0	5	0	1
R:R:F202	R:R:W487	11.02	1	Yes	Yes	8	7	2	2
R:R:F202	R:R:L495	2.44	1	Yes	No	8	4	2	1
H:H:?2	R:R:N203	33.07	0	No	No	0	4	0	1
R:R:L495	R:R:W487	3.42	1	No	Yes	4	7	1	2
H:H:?2	R:R:L495	3.7	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	12.98
Average Nodes In Shell	8.00
Average Hubs In Shell	2.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7MTS

Aminoacid

Metabotropic glutamate

mGlu2; mGlu2

Homo sapiens

Glutamate

ADX55164

Gi1/Beta1/Gamma2

3.2

2021-07-07

10.1038/s41586-021-03680-3

A 2D representation of the interactions of NAG in 7MTS
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N203	R:R:R200	6.03	0	No	No	4	4	1	2
H:H:?1	R:R:N203	26.95	0	No	No	0	4	0	1
R:R:L495	R:R:W487	2.28	13	No	Yes	4	7	1	2
R:R:P496	R:R:W487	4.05	13	No	Yes	8	7	2	2
R:R:L495	R:R:P496	3.28	13	No	No	4	8	1	2
H:H:?1	R:R:L495	3.7	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.32
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	2.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7MTS
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N203	S:S:R200	4.82	0	No	No	4	4	1	2
S:S:F202	S:S:W487	5.01	3	Yes	Yes	8	7	2	2
S:S:F202	S:S:L495	2.44	3	Yes	Yes	8	4	2	1
H:H:?2	S:S:N203	29.4	0	No	No	0	4	0	1
S:S:L495	S:S:W487	2.28	3	Yes	Yes	4	7	1	2
S:S:P496	S:S:W487	6.76	3	No	Yes	8	7	2	2
S:S:L495	S:S:P496	4.93	3	Yes	No	4	8	1	2
H:H:?2	S:S:L495	2.47	0	No	Yes	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	15.93
Average Nodes In Shell	7.00
Average Hubs In Shell	3.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7QA8

Ste2-like

STE2

Saccharomyces cerevisiae

Peptide

2.7

2022-03-16

10.1038/s41586-022-04498-3

A 2D representation of the interactions of NAG in 7QA8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N25	R:R:T23	2.92	No	No	7	5	1	2
H:H:?1	R:R:N25	29.4	No	No	0	7	0	1
H:H:?4	R:R:N25	2.45	Yes	No	0	7	2	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	29.40
Average Nodes In Shell	4.00
Average Hubs In Shell	1.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7QA8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?4	R:R:N25	2.45	Yes	No	0	7	1	2
R:R:N32	R:R:T27	4.39	No	No	5	5	1	2
H:H:?2	R:R:N32	24.5	No	No	0	5	0	1
H:H:?4	S:S:N25	28.17	Yes	No	0	7	1	2
H:H:?4	S:S:T35	2.63	Yes	No	0	4	1	2
R:R:G31	R:R:N32	1.7	No	No	8	5	2	1
H:H:?2	H:H:?4	1.1	No	Yes	0	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	12.80
Average Nodes In Shell	8.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7QA8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N32	S:S:T27	4.39	No	No	5	5	1	2
H:H:?3	S:S:N32	24.5	No	No	0	5	0	1
S:S:G31	S:S:N32	1.7	No	No	8	5	2	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	24.50
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7QA8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N25	R:R:T23	2.92	No	No	7	5	1	2
H:H:?1	R:R:N25	29.4	No	No	0	7	2	1
H:H:?4	R:R:N25	2.45	Yes	No	0	7	0	1
H:H:?2	R:R:N32	24.5	No	No	0	5	1	2
S:S:N25	S:S:T23	2.92	No	No	7	5	1	2
S:S:T23	S:S:T35	3.14	No	No	5	4	2	1
H:H:?4	S:S:N25	28.17	Yes	No	0	7	0	1
H:H:?4	S:S:T35	2.63	Yes	No	0	4	0	1
H:H:?2	H:H:?4	1.1	No	Yes	0	0	1	0

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	8.59
Average Nodes In Shell	9.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7QB9

Ste2-like

STE2

Saccharomyces cerevisiae

3.1

2022-03-16

10.1038/s41586-022-04498-3

A 2D representation of the interactions of NAG in 7QB9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N25	S:S:N25	6.81	No	No	7	7	1	2
H:H:?1	R:R:N25	28.17	No	No	0	7	0	1
H:H:?1	R:R:T35	2.63	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.40
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7QB9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N32	R:R:T27	4.39	No	No	5	5	1	2
H:H:?2	R:R:N32	29.4	No	No	0	5	0	1
R:R:G31	R:R:N32	1.7	No	No	8	5	2	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	29.40
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7QB9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N25	S:S:N25	6.81	No	No	7	7	2	1
H:H:?3	S:S:N25	28.17	No	No	0	7	0	1
H:H:?3	S:S:T35	2.63	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.40
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7QB9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N32	S:S:T27	4.39	No	No	5	5	1	2
H:H:?4	S:S:N32	29.4	No	No	0	5	0	1
S:S:G31	S:S:N32	1.7	No	No	8	5	2	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	29.40
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7QBC

Ste2-like

STE2

Saccharomyces cerevisiae

Alpha-factor mating pheromone

3.53

2022-03-16

10.1038/s41586-022-04498-3

A 2D representation of the interactions of NAG in 7QBC
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:T23	R:R:T35	3.14	No	No	5	4	1	2
H:H:?1	R:R:T23	6.57	No	No	0	5	0	1
H:H:?1	R:R:N25	30.62	No	No	0	7	0	1
S:S:N32	S:S:T27	2.92	No	No	5	5	2	1
R:R:Y17	S:S:T27	2.5	Yes	No	7	5	2	1
R:R:N25	S:S:N25	1.36	No	No	7	7	1	2
H:H:?1	S:S:T27	1.31	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	12.83
Average Nodes In Shell	8.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7QBC
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?2	R:R:N32	34.3	No	No	0	5	0	1
R:R:N32	R:R:T27	2.92	No	No	5	5	1	2
R:R:G33	R:R:N32	1.7	No	No	2	5	2	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	34.30
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7QBC
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:T23	S:S:T35	3.14	No	No	5	4	1	2
H:H:?3	S:S:T23	6.57	No	No	0	5	0	1
H:H:?3	S:S:N25	30.62	No	No	0	7	0	1
R:R:N32	R:R:T27	2.92	No	No	5	5	2	1
R:R:T27	S:S:Y17	2.5	No	Yes	5	7	1	2
R:R:N25	S:S:N25	1.36	No	No	7	7	2	1
H:H:?3	R:R:T27	1.31	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	12.83
Average Nodes In Shell	8.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7QBC
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?4	S:S:N32	34.3	No	No	0	5	0	1
S:S:N32	S:S:T27	2.92	No	No	5	5	1	2
S:S:G33	S:S:N32	1.7	No	No	2	5	2	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	34.30
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7QBI

Ste2-like

STE2

Saccharomyces cerevisiae

Alpha-factor mating pheromone

3.46

2022-03-16

10.1038/s41586-022-04498-3

A 2D representation of the interactions of NAG in 7QBI
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:N25	25.72	No	No	0	7	0	1
H:H:?3	S:S:N32	23.27	No	No	0	5	1	2
H:H:?1	H:H:?3	3.3	No	No	0	0	0	1
R:R:N25	R:R:T35	2.92	No	No	7	4	1	2
R:R:N25	S:S:N25	1.36	No	No	7	7	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.51
Average Nodes In Shell	6.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7QBI
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?2	R:R:N32	23.27	0	No	No	0	5	0	1
R:R:G33	R:R:N32	1.7	0	No	No	2	5	2	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	23.27
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7QBI
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:N25	25.72	No	No	0	7	1	2
H:H:?3	S:S:N32	23.27	No	No	0	5	0	1
H:H:?1	H:H:?3	3.3	No	No	0	0	1	0
S:S:G33	S:S:N32	1.7	No	No	2	5	2	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.29
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7QBI
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?4	S:S:N25	26.95	No	No	0	7	0	1
H:H:?4	S:S:T35	5.26	No	No	0	4	0	1
S:S:T23	S:S:T35	1.57	No	No	5	4	2	1
R:R:N25	S:S:N25	1.36	No	No	7	7	2	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	16.11
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7RKF

Other

Unclassified

US28

Human betaherpesvirus 5

Fractalkine

GDP

chim(NtGi1-G11)/Beta1/Gamma2

2022-01-26

10.1126/sciadv.abl5442

A 2D representation of the interactions of NAG in 7RKF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:C8	L:L:Q31	3.05	6	No	No	0	0	2	1
L:L:C8	L:L:S33	3.44	6	No	Yes	0	0	2	2
L:L:I10	L:L:N9	7.08	6	Yes	Yes	0	0	1	1
L:L:N9	R:R:V24	5.91	6	Yes	No	0	2	1	2
H:H:?1	L:L:N9	23.27	6	Yes	Yes	0	0	0	1
L:L:C12	L:L:I10	3.27	6	No	Yes	0	0	2	1
L:L:I10	L:L:N30	2.83	6	Yes	No	0	0	1	2
L:L:I10	L:L:I40	2.94	6	Yes	No	0	0	1	2
H:H:?1	L:L:I10	2.55	6	Yes	Yes	0	0	0	1
L:L:H26	L:L:Q28	6.18	0	No	No	0	0	2	1
L:L:I40	L:L:Q28	4.12	0	No	No	0	0	2	1
H:H:?1	L:L:Q28	4.75	6	Yes	No	0	0	0	1
L:L:Q31	L:L:S33	7.22	6	No	Yes	0	0	1	2
H:H:?1	L:L:Q31	5.94	6	Yes	No	0	0	0	1
R:R:N30	R:R:T26	5.85	0	No	No	4	4	2	1
H:H:?1	R:R:T26	11.83	6	Yes	No	0	4	0	1
L:L:N9	R:R:F25	1.21	6	Yes	Yes	0	3	1	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	9.67
Average Nodes In Shell	15.00
Average Hubs In Shell	5.00
Average Links In Shell	17.00
Average Links Mediated by Hubs In Shell	13.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7SIL

Ion

Calcium-sensing

CaS

Homo sapiens

Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4

2.7

2022-01-19

10.1073/pnas.2115849118

A 2D representation of the interactions of NAG in 7SIL
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E475	R:R:K323	6.75	0	No	No	5	5	2	1
H:H:?1	R:R:K323	6.29	27	Yes	No	0	5	0	1
R:R:V486	R:R:Y514	3.79	0	No	Yes	3	4	2	1
R:R:N488	R:R:N512	6.81	27	No	Yes	4	4	1	1
R:R:N488	R:R:Y514	4.65	27	No	Yes	4	4	1	1
H:H:?1	R:R:N488	25.72	27	Yes	No	0	4	0	1
R:R:F522	R:R:Y510	18.57	0	No	No	1	3	2	1
H:H:?1	R:R:Y510	11.5	27	Yes	No	0	3	0	1
R:R:N512	R:R:Y514	4.65	27	Yes	Yes	4	4	1	1
R:R:A515	R:R:N512	6.25	0	No	Yes	4	4	2	1
H:H:?1	R:R:N512	20.82	27	Yes	Yes	0	4	0	1
R:R:V513	R:R:Y514	5.05	0	No	Yes	3	4	2	1
H:H:?1	R:R:Y514	10.46	27	Yes	Yes	0	4	0	1
H:H:?1	H:H:?2	37.44	27	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	18.70
Average Nodes In Shell	12.00
Average Hubs In Shell	3.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7SIL
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:K323	6.29	27	Yes	No	0	5	1	2
R:R:N488	R:R:N512	6.81	27	No	Yes	4	4	2	2
R:R:N488	R:R:Y514	4.65	27	No	Yes	4	4	2	2
H:H:?1	R:R:N488	25.72	27	Yes	No	0	4	1	2
H:H:?1	R:R:Y510	11.5	27	Yes	No	0	3	1	2
R:R:N512	R:R:Y514	4.65	27	Yes	Yes	4	4	2	2
H:H:?1	R:R:N512	20.82	27	Yes	Yes	0	4	1	2
H:H:?1	R:R:Y514	10.46	27	Yes	Yes	0	4	1	2
H:H:?1	H:H:?2	37.44	27	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	37.44
Average Nodes In Shell	7.00
Average Hubs In Shell	3.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7SIL
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?4	R:R:E202	4.73	0	No	No	0	5	1	2
H:H:?3	R:R:R205	8.67	25	Yes	No	0	4	0	1
R:R:N207	R:R:N541	17.71	25	No	No	6	5	1	1
R:R:C561	R:R:N207	9.45	0	No	No	9	6	2	1
H:H:?3	R:R:N207	15.92	25	Yes	No	0	6	0	1
R:R:F539	R:R:N541	6.04	25	No	No	1	5	1	1
R:R:F539	R:R:R544	24.59	25	No	No	1	5	1	2
H:H:?3	R:R:F539	5.43	25	Yes	No	0	1	0	1
H:H:?3	R:R:N541	25.72	25	Yes	No	0	5	0	1
R:R:D545	R:R:F563	3.58	0	No	No	5	7	1	2
R:R:D545	R:R:D578	15.97	0	No	No	5	7	1	2
H:H:?3	R:R:D545	16.95	25	Yes	No	0	5	0	1
H:H:?3	H:H:?4	38.55	25	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.54
Average Nodes In Shell	12.00
Average Hubs In Shell	1.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7SIL
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E202	R:R:R233	13.96	0	No	Yes	5	4	1	2
H:H:?4	R:R:E202	4.73	0	No	No	0	5	0	1
H:H:?3	R:R:R205	8.67	25	Yes	No	0	4	1	2
R:R:N207	R:R:N541	17.71	25	No	No	6	5	2	2
H:H:?3	R:R:N207	15.92	25	Yes	No	0	6	1	2
R:R:F539	R:R:N541	6.04	25	No	No	1	5	2	2
H:H:?3	R:R:F539	5.43	25	Yes	No	0	1	1	2
H:H:?3	R:R:N541	25.72	25	Yes	No	0	5	1	2
H:H:?3	R:R:D545	16.95	25	Yes	No	0	5	1	2
H:H:?3	H:H:?4	38.55	25	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	21.64
Average Nodes In Shell	9.00
Average Hubs In Shell	2.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7SIL
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:E475	S:S:K323	4.05	0	No	No	5	5	2	1
H:H:?5	S:S:K323	7.55	22	Yes	No	0	5	0	1
S:S:V486	S:S:Y514	3.79	0	No	Yes	3	4	2	1
S:S:N488	S:S:N512	6.81	22	No	Yes	4	4	1	1
S:S:N488	S:S:Y514	4.65	22	No	Yes	4	4	1	1
H:H:?5	S:S:N488	25.72	22	Yes	No	0	4	0	1
S:S:F522	S:S:Y510	18.57	0	No	No	1	3	2	1
H:H:?5	S:S:Y510	11.5	22	Yes	No	0	3	0	1
S:S:N512	S:S:Y514	4.65	22	Yes	Yes	4	4	1	1
S:S:A515	S:S:N512	6.25	0	No	Yes	4	4	2	1
H:H:?5	S:S:N512	19.6	22	Yes	Yes	0	4	0	1
H:H:?6	S:S:N512	3.67	22	No	Yes	0	4	1	1
S:S:V513	S:S:Y514	5.05	0	No	Yes	3	4	2	1
H:H:?5	S:S:Y514	7.32	22	Yes	Yes	0	4	0	1
H:H:?5	H:H:?6	37.44	22	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	18.19
Average Nodes In Shell	12.00
Average Hubs In Shell	3.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	13.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7SIL
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?5	S:S:K323	7.55	22	Yes	No	0	5	1	2
S:S:N488	S:S:N512	6.81	22	No	Yes	4	4	2	1
S:S:N488	S:S:Y514	4.65	22	No	Yes	4	4	2	2
H:H:?5	S:S:N488	25.72	22	Yes	No	0	4	1	2
H:H:?5	S:S:Y510	11.5	22	Yes	No	0	3	1	2
S:S:N512	S:S:Y514	4.65	22	Yes	Yes	4	4	1	2
S:S:A515	S:S:N512	6.25	0	No	Yes	4	4	2	1
H:H:?5	S:S:N512	19.6	22	Yes	Yes	0	4	1	1
H:H:?6	S:S:N512	3.67	22	No	Yes	0	4	0	1
H:H:?5	S:S:Y514	7.32	22	Yes	Yes	0	4	1	2
H:H:?5	H:H:?6	37.44	22	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	20.55
Average Nodes In Shell	8.00
Average Hubs In Shell	3.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7SIL
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?7	S:S:R205	7.59	19	Yes	No	0	4	0	1
H:H:?8	S:S:R205	7.59	19	No	No	0	4	1	1
S:S:N207	S:S:N541	17.71	19	No	No	6	5	1	1
S:S:C561	S:S:N207	9.45	0	No	No	9	6	2	1
H:H:?7	S:S:N207	15.92	19	Yes	No	0	6	0	1
S:S:F539	S:S:N541	6.04	19	No	No	1	5	1	1
S:S:F539	S:S:R544	25.66	19	No	No	1	5	1	2
H:H:?7	S:S:F539	5.43	19	Yes	No	0	1	0	1
H:H:?7	S:S:N541	25.72	19	Yes	No	0	5	0	1
S:S:D545	S:S:F563	3.58	0	No	No	5	7	1	2
S:S:D545	S:S:D578	15.97	0	No	No	5	7	1	2
H:H:?7	S:S:D545	18.16	19	Yes	No	0	5	0	1
H:H:?7	H:H:?8	40.75	19	Yes	No	0	0	0	1
H:H:?8	S:S:D234	1.21	19	No	No	0	5	1	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.93
Average Nodes In Shell	12.00
Average Hubs In Shell	1.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7SIL
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:G557	S:S:D234	5.03	0	No	No	6	5	2	1
H:H:?7	S:S:R205	7.59	19	Yes	No	0	4	1	1
H:H:?8	S:S:R205	7.59	19	No	No	0	4	0	1
S:S:N207	S:S:N541	17.71	19	No	No	6	5	2	2
H:H:?7	S:S:N207	15.92	19	Yes	No	0	6	1	2
S:S:F539	S:S:N541	6.04	19	No	No	1	5	2	2
H:H:?7	S:S:F539	5.43	19	Yes	No	0	1	1	2
H:H:?7	S:S:N541	25.72	19	Yes	No	0	5	1	2
H:H:?7	S:S:D545	18.16	19	Yes	No	0	5	1	2
H:H:?7	H:H:?8	40.75	19	Yes	No	0	0	1	0
H:H:?8	S:S:D234	1.21	19	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	16.52
Average Nodes In Shell	9.00
Average Hubs In Shell	1.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7SIL
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E257	R:R:R286	6.98	No	Yes	3	4	1	2
H:H:?9	R:R:E257	4.73	No	No	0	3	0	1
H:H:?9	R:R:N261	28.17	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	16.45
Average Nodes In Shell	4.00
Average Hubs In Shell	1.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7SIL
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H312	R:R:V284	5.54	4	Yes	No	3	3	1	2
R:R:V284	R:R:V313	6.41	4	No	No	3	3	2	2
R:R:N287	R:R:T289	5.85	4	No	No	6	5	1	1
R:R:H312	R:R:N287	6.38	4	Yes	No	3	6	1	1
H:H:?10	R:R:N287	31.85	4	No	No	0	6	0	1
H:H:?10	R:R:T289	10.52	4	No	No	0	5	0	1
R:R:H312	R:R:V313	5.54	4	Yes	No	3	3	1	2
H:H:?10	R:R:H312	3.44	4	No	Yes	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	15.27
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7SIL
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N468	R:R:Q476	5.28	28	No	No	6	3	1	1
R:R:N468	R:R:T478	5.85	28	No	No	6	3	1	1
H:H:?11	R:R:N468	33.07	28	No	No	0	6	0	1
R:R:Q476	R:R:T470	8.5	28	No	No	3	5	1	2
H:H:?11	R:R:Q476	9.5	28	No	No	0	3	0	1
H:H:?11	R:R:T478	3.94	28	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.50
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7SIL
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:F239	S:S:V258	6.55	3	Yes	Yes	6	4	2	1
S:S:E241	S:S:H254	4.92	3	No	No	5	3	2	2
S:S:E241	S:S:V258	11.41	3	No	Yes	5	4	2	1
S:S:H254	S:S:V258	5.54	3	No	Yes	3	4	2	1
H:H:?12	S:S:N261	28.17	0	No	No	0	4	0	1
H:H:?12	S:S:V258	1.33	0	No	Yes	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	14.75
Average Nodes In Shell	6.00
Average Hubs In Shell	2.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7SIL
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N287	S:S:T289	5.85	3	No	No	6	5	1	1
S:S:H312	S:S:N287	3.83	3	No	No	3	6	2	1
H:H:?13	S:S:N287	26.95	3	No	No	0	6	0	1
H:H:?13	S:S:T289	6.57	3	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	16.76
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7SIL
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N468	S:S:Q476	5.28	39	No	No	6	3	1	1
S:S:N468	S:S:T478	5.85	39	No	No	6	3	1	2
H:H:?14	S:S:N468	30.62	39	No	No	0	6	0	1
S:S:Q476	S:S:T470	7.09	39	No	No	3	5	1	2
H:H:?14	S:S:Q476	10.69	39	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	20.66
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7SIM

Ion

Calcium-sensing

CaS

Homo sapiens

Ca; Ca; Cyclomethyltryptophan; PO4

2.7

2022-01-19

10.1073/pnas.2115849118

A 2D representation of the interactions of NAG in 7SIM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E475	R:R:K323	5.4	1	No	No	5	5	1	1
H:H:?1	R:R:K323	7.55	1	Yes	No	0	5	0	1
R:R:E475	R:R:N471	5.26	1	No	Yes	5	6	1	2
H:H:?1	R:R:E475	4.73	1	Yes	No	0	5	0	1
R:R:V486	R:R:Y514	5.05	0	No	Yes	3	4	2	1
R:R:N488	R:R:N512	6.81	1	No	Yes	4	4	1	1
R:R:N488	R:R:Y514	4.65	1	No	Yes	4	4	1	1
H:H:?1	R:R:N488	26.95	1	Yes	No	0	4	0	1
R:R:F522	R:R:Y510	16.5	0	No	No	1	3	2	1
H:H:?1	R:R:Y510	11.5	1	Yes	No	0	3	0	1
R:R:N512	R:R:Y514	4.65	1	Yes	Yes	4	4	1	1
R:R:A515	R:R:N512	4.69	0	No	Yes	4	4	2	1
H:H:?1	R:R:N512	22.05	1	Yes	Yes	0	4	0	1
R:R:V513	R:R:Y514	3.79	0	No	Yes	3	4	2	1
H:H:?1	R:R:Y514	9.41	1	Yes	Yes	0	4	0	1
H:H:?1	H:H:?2	42.95	1	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	17.88
Average Nodes In Shell	13.00
Average Hubs In Shell	4.00
Average Links In Shell	16.00
Average Links Mediated by Hubs In Shell	14.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7SIM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E475	R:R:K323	5.4	1	No	No	5	5	2	2
H:H:?1	R:R:K323	7.55	1	Yes	No	0	5	1	2
H:H:?1	R:R:E475	4.73	1	Yes	No	0	5	1	2
R:R:N488	R:R:N512	6.81	1	No	Yes	4	4	2	2
R:R:N488	R:R:Y514	4.65	1	No	Yes	4	4	2	2
H:H:?1	R:R:N488	26.95	1	Yes	No	0	4	1	2
H:H:?1	R:R:Y510	11.5	1	Yes	No	0	3	1	2
R:R:N512	R:R:Y514	4.65	1	Yes	Yes	4	4	2	2
H:H:?1	R:R:N512	22.05	1	Yes	Yes	0	4	1	2
H:H:?1	R:R:Y514	9.41	1	Yes	Yes	0	4	1	2
H:H:?1	H:H:?2	42.95	1	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	42.95
Average Nodes In Shell	8.00
Average Hubs In Shell	3.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7SIM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R205	8.67	14	Yes	No	0	4	0	1
H:H:?4	R:R:R205	4.33	14	No	No	0	4	1	1
R:R:N207	R:R:N541	17.71	14	No	No	6	5	1	1
R:R:C561	R:R:N207	7.87	0	No	No	9	6	2	1
H:H:?3	R:R:N207	12.25	14	Yes	No	0	6	0	1
R:R:F539	R:R:N541	7.25	14	No	No	1	5	1	1
R:R:F539	R:R:R544	26.72	14	No	No	1	5	1	2
H:H:?3	R:R:F539	5.43	14	Yes	No	0	1	0	1
H:H:?3	R:R:N541	25.72	14	Yes	No	0	5	0	1
R:R:D545	R:R:T577	5.78	0	No	No	5	5	1	2
R:R:D545	R:R:D578	3.99	0	No	No	5	7	1	2
H:H:?3	R:R:D545	3.63	14	Yes	No	0	5	0	1
H:H:?3	H:H:?4	36.34	14	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.34
Average Nodes In Shell	11.00
Average Hubs In Shell	1.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7SIM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R205	8.67	14	Yes	No	0	4	1	1
H:H:?4	R:R:R205	4.33	14	No	No	0	4	0	1
R:R:N207	R:R:N541	17.71	14	No	No	6	5	2	2
H:H:?3	R:R:N207	12.25	14	Yes	No	0	6	1	2
R:R:F539	R:R:N541	7.25	14	No	No	1	5	2	2
H:H:?3	R:R:F539	5.43	14	Yes	No	0	1	1	2
H:H:?3	R:R:N541	25.72	14	Yes	No	0	5	1	2
H:H:?3	R:R:D545	3.63	14	Yes	No	0	5	1	2
H:H:?3	H:H:?4	36.34	14	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	20.34
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7SIM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:E475	S:S:K323	5.4	2	No	No	5	5	1	1
H:H:?5	S:S:K323	7.55	2	Yes	No	0	5	0	1
S:S:E475	S:S:N471	3.94	2	No	Yes	5	6	1	2
H:H:?5	S:S:E475	3.55	2	Yes	No	0	5	0	1
S:S:V486	S:S:Y514	5.05	0	No	Yes	3	4	2	1
S:S:N488	S:S:N512	6.81	2	No	Yes	4	4	1	1
S:S:N488	S:S:Y514	4.65	2	No	Yes	4	4	1	1
H:H:?5	S:S:N488	25.72	2	Yes	No	0	4	0	1
S:S:F522	S:S:Y510	16.5	0	No	No	1	3	2	1
H:H:?5	S:S:Y510	11.5	2	Yes	No	0	3	0	1
S:S:N512	S:S:Y514	4.65	2	Yes	Yes	4	4	1	1
S:S:A515	S:S:N512	4.69	0	No	Yes	4	4	2	1
H:H:?5	S:S:N512	23.27	2	Yes	Yes	0	4	0	1
H:H:?6	S:S:N512	3.67	2	No	Yes	0	4	1	1
S:S:V513	S:S:Y514	3.79	0	No	Yes	3	4	2	1
H:H:?5	S:S:Y514	8.37	2	Yes	Yes	0	4	0	1
H:H:?5	H:H:?6	41.85	2	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	17.40
Average Nodes In Shell	13.00
Average Hubs In Shell	4.00
Average Links In Shell	17.00
Average Links Mediated by Hubs In Shell	15.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7SIM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:E475	S:S:K323	5.4	2	No	No	5	5	2	2
H:H:?5	S:S:K323	7.55	2	Yes	No	0	5	1	2
H:H:?5	S:S:E475	3.55	2	Yes	No	0	5	1	2
S:S:N488	S:S:N512	6.81	2	No	Yes	4	4	2	1
S:S:N488	S:S:Y514	4.65	2	No	Yes	4	4	2	2
H:H:?5	S:S:N488	25.72	2	Yes	No	0	4	1	2
H:H:?5	S:S:Y510	11.5	2	Yes	No	0	3	1	2
S:S:N512	S:S:Y514	4.65	2	Yes	Yes	4	4	1	2
S:S:A515	S:S:N512	4.69	0	No	Yes	4	4	2	1
H:H:?5	S:S:N512	23.27	2	Yes	Yes	0	4	1	1
H:H:?6	S:S:N512	3.67	2	No	Yes	0	4	0	1
H:H:?5	S:S:Y514	8.37	2	Yes	Yes	0	4	1	2
H:H:?5	H:H:?6	41.85	2	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	22.76
Average Nodes In Shell	9.00
Average Hubs In Shell	3.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7SIM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?7	S:S:R205	13	25	Yes	No	0	4	0	1
S:S:N207	S:S:N541	17.71	25	No	No	6	5	1	1
S:S:C561	S:S:N207	7.87	0	No	No	9	6	2	1
H:H:?7	S:S:N207	12.25	25	Yes	No	0	6	0	1
S:S:F539	S:S:N541	7.25	25	No	No	1	5	1	1
S:S:F539	S:S:R544	32.07	25	No	No	1	5	1	2
H:H:?7	S:S:F539	6.52	25	Yes	No	0	1	0	1
H:H:?7	S:S:N541	25.72	25	Yes	No	0	5	0	1
H:H:?7	H:H:?8	29.74	25	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	17.45
Average Nodes In Shell	8.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7SIM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?7	S:S:R205	13	25	Yes	No	0	4	1	2
S:S:N207	S:S:N541	17.71	25	No	No	6	5	2	2
H:H:?7	S:S:N207	12.25	25	Yes	No	0	6	1	2
S:S:F539	S:S:N541	7.25	25	No	No	1	5	2	2
H:H:?7	S:S:F539	6.52	25	Yes	No	0	1	1	2
H:H:?7	S:S:N541	25.72	25	Yes	No	0	5	1	2
H:H:?7	H:H:?8	29.74	25	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	29.74
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7SIM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N468	R:R:Q476	7.92	33	No	No	6	3	1	1
R:R:N468	R:R:T478	8.77	33	No	No	6	3	1	2
H:H:?9	R:R:N468	24.5	33	No	No	0	6	0	1
R:R:Q476	R:R:T470	8.5	33	No	No	3	5	1	2
H:H:?9	R:R:Q476	14.25	33	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	19.38
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7SIM
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N468	S:S:Q476	7.92	44	No	No	6	3	1	1
S:S:N468	S:S:T478	10.24	44	No	No	6	3	1	2
H:H:?10	S:S:N468	23.27	44	No	No	0	6	0	1
S:S:Q476	S:S:T470	8.5	44	No	No	3	5	1	2
H:H:?10	S:S:Q476	14.25	44	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.76
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7SRQ

Amine

5-Hydroxytryptamine

5-HT2B

Homo sapiens

LSD

2.7

2022-09-21

10.1016/j.neuron.2022.08.006

A 2D representation of the interactions of NAG in 7SRQ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N201	R:R:P202	4.89	3	Yes	No	2	3	1	2
R:R:N201	R:R:N203	4.09	3	Yes	No	2	4	1	1
R:R:N201	R:R:N204	12.26	3	Yes	No	2	3	1	1
H:H:?1	R:R:N201	4.9	3	No	Yes	0	2	0	1
H:H:?1	R:R:N203	7.35	3	No	No	0	4	0	1
H:H:?1	R:R:N204	25.72	3	No	No	0	3	0	1
R:R:N204	R:R:V199	1.48	3	No	No	3	3	1	2
R:R:M120	R:R:N203	1.4	0	No	No	3	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	12.66
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7SRS

Amine

5-Hydroxytryptamine

5-HT2B

Homo sapiens

LSD

Arrestin2

3.3

2022-09-21

10.1016/j.neuron.2022.08.006

A 2D representation of the interactions of NAG in 7SRS
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N201	R:R:P202	4.89	17	No	No	2	3	1	2
R:R:N201	R:R:N203	2.72	17	No	No	2	4	1	1
H:H:?1	R:R:N201	4.9	17	No	No	0	2	0	1
H:H:?1	R:R:N203	2.45	17	No	No	0	4	0	1
H:H:?1	R:R:N204	29.4	17	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	12.25
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7T9I

Protein

Glycoprotein hormone

TSH

Homo sapiens

TSH

Gs/Beta1/Gamma2

2.9

2022-08-03

10.1038/s41586-022-05159-1

A 2D representation of the interactions of NAG in 7T9I
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
L:L:K44	L:L:N52	4.2	0	No	Yes	2	1
L:L:N52	M:M:Y59	5.81	15	Yes	Yes	1	1
L:L:N52	M:M:P78	3.26	15	Yes	No	1	2
H:H:?1	L:L:N52	34.3	15	Yes	Yes	0	1
L:L:V53	M:M:Y92	3.79	15	No	Yes	2	1
L:L:V53	M:M:S93	6.46	15	No	No	2	2
M:M:F57	M:M:Y59	6.19	0	Yes	Yes	2	1
M:M:F57	M:M:P78	5.78	0	Yes	No	2	2
M:M:F57	M:M:Y92	8.25	0	Yes	Yes	2	1
H:H:?1	M:M:Y59	16.73	15	Yes	Yes	0	1
H:H:?2	M:M:Y59	4.18	15	No	Yes	1	1
M:M:N89	M:M:Y92	16.28	0	No	Yes	2	1
M:M:S93	M:M:Y92	6.36	15	No	Yes	2	1
H:H:?1	M:M:Y92	3.14	15	Yes	Yes	0	1
H:H:?1	H:H:?2	63.88	15	Yes	No	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	29.51
Average Nodes In Shell	11.00
Average Hubs In Shell	5.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	14.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7T9I
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
L:L:N52	M:M:Y59	5.81	15	Yes	Yes	2	1
H:H:?1	L:L:N52	34.3	15	Yes	Yes	1	2
M:M:F57	M:M:Y59	6.19	0	Yes	Yes	2	1
M:M:F57	M:M:Y92	8.25	0	Yes	Yes	2	2
H:H:?1	M:M:Y59	16.73	15	Yes	Yes	1	1
H:H:?2	M:M:Y59	4.18	15	No	Yes	0	1
H:H:?1	M:M:Y92	3.14	15	Yes	Yes	1	2
H:H:?1	H:H:?2	63.88	15	Yes	No	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	34.03
Average Nodes In Shell	6.00
Average Hubs In Shell	5.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7T9I
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
L:L:L12	L:L:L26	8.3	0	No	No	2	1
H:H:?3	L:L:P24	7.32	21	Yes	No	0	1
L:L:L26	L:L:N78	4.12	21	No	Yes	1	1
H:H:?3	L:L:L26	6.17	21	Yes	No	0	1
L:L:N66	L:L:V68	4.43	21	No	No	2	1
L:L:N66	L:L:N78	8.17	21	No	Yes	2	1
L:L:N78	L:L:V68	4.43	21	Yes	No	1	1
H:H:?3	L:L:V68	3.99	21	Yes	No	0	1
H:H:?3	L:L:N78	30.62	21	Yes	Yes	0	1
L:L:G22	L:L:P24	2.03	0	No	No	2	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	12.03
Average Nodes In Shell	8.00
Average Hubs In Shell	2.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7T9I
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
M:M:N23	M:M:T8	7.31	0	No	No	0	0	1	2
H:H:?4	M:M:N23	30.62	0	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	30.62
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7T9I
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H70	R:R:H95	8.36	22	Yes	No	4	5	2	2
R:R:H70	R:R:Y98	4.36	22	Yes	Yes	4	2	2	1
R:R:H95	R:R:Y98	11.98	22	No	Yes	5	2	2	1
R:R:N99	R:R:Y98	6.98	22	No	Yes	5	2	1	1
R:R:K123	R:R:Y98	3.58	0	No	Yes	4	2	2	1
H:H:?5	R:R:Y98	3.14	22	No	Yes	0	2	0	1
H:H:?5	R:R:N99	33.07	22	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	18.11
Average Nodes In Shell	6.00
Average Hubs In Shell	2.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7T9I
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N77	R:R:Q55	6.6	35	Yes	No	8	4	1	2
R:R:N77	R:R:P76	6.52	35	Yes	No	8	5	1	1
H:H:?6	R:R:P76	2.93	35	No	No	0	5	0	1
H:H:?6	R:R:N77	25.72	35	No	Yes	0	8	0	1
R:R:K102	R:R:N77	2.8	0	No	Yes	4	8	2	1
R:R:L75	R:R:P76	1.64	0	No	No	6	5	2	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	14.32
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7T9I
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N170	R:R:V169	2.96	23	Yes	No	8	5	1	2
R:R:N170	R:R:Q173	15.85	23	Yes	No	8	2	1	1
R:R:N170	R:R:N198	5.45	23	Yes	Yes	8	7	1	1
H:H:?7	R:R:N170	11.02	23	Yes	Yes	0	8	0	1
R:R:N198	R:R:Q173	5.28	23	Yes	No	7	2	1	1
H:H:?7	R:R:Q173	10.69	23	Yes	No	0	2	0	1
R:R:N198	R:R:Y195	5.81	23	Yes	Yes	7	4	1	1
R:R:D219	R:R:Y195	4.6	0	No	Yes	3	4	2	1
R:R:G222	R:R:Y195	2.9	0	No	Yes	3	4	2	1
H:H:?7	R:R:Y195	5.23	23	Yes	Yes	0	4	0	1
R:R:G199	R:R:N198	3.39	0	No	Yes	7	7	2	1
R:R:G223	R:R:N198	3.39	0	No	Yes	7	7	2	1
H:H:?7	R:R:N198	24.5	23	Yes	Yes	0	7	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	12.86
Average Nodes In Shell	10.00
Average Hubs In Shell	4.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	13.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7T9I
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E178	R:R:I152	6.83	38	Yes	No	5	3	1	2
R:R:E178	R:R:N177	3.94	38	Yes	No	5	5	1	1
H:H:?8	R:R:N177	29.4	38	No	No	0	5	0	1
H:H:?8	R:R:E178	11.82	38	No	Yes	0	5	0	1
R:R:E178	R:R:K201	2.7	38	Yes	No	5	4	1	2
H:H:?8	R:R:T150	2.63	38	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	14.62
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7T9M

Protein

Glycoprotein hormone

TSH

Homo sapiens

CS-17 Antibody

3.1

2022-08-10

10.1038/s41586-022-05159-1

A 2D representation of the interactions of NAG in 7T9M
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
W:W:S31	W:W:Y102	7.63	1	No	Yes	0	0	2	1
W:W:R104	W:W:S31	3.95	1	Yes	No	0	0	1	2
W:W:D100	W:W:Y32	17.24	1	Yes	Yes	0	0	2	2
W:W:R104	W:W:Y32	5.14	1	Yes	Yes	0	0	1	2
W:W:Y101	W:W:Y54	13.9	1	Yes	No	0	0	2	2
W:W:Y102	W:W:Y54	6.95	1	Yes	No	0	0	1	2
W:W:D100	W:W:G103	5.03	1	Yes	No	0	0	2	2
W:W:D100	W:W:R104	15.48	1	Yes	Yes	0	0	2	1
W:W:Y101	W:W:Y102	8.94	1	Yes	Yes	0	0	2	1
R:R:G223	W:W:Y101	5.79	1	No	Yes	7	0	2	2
R:R:K244	W:W:Y101	3.58	1	Yes	Yes	3	0	2	2
W:W:R104	W:W:Y102	9.26	1	Yes	Yes	0	0	1	1
R:R:G223	W:W:Y102	2.9	1	No	Yes	7	0	2	1
H:H:?1	W:W:Y102	3.14	1	Yes	Yes	0	0	0	1
R:R:Y195	W:W:G103	7.24	1	Yes	No	4	0	1	2
H:H:?1	W:W:R104	4.33	1	Yes	Yes	0	0	0	1
H:H:?2	W:W:R104	8.67	1	No	Yes	0	0	1	1
R:R:N170	R:R:V169	4.43	1	Yes	No	8	5	1	2
R:R:N170	R:R:Q173	10.56	1	Yes	No	8	2	1	1
R:R:N170	R:R:N198	8.17	1	Yes	Yes	8	7	1	1
H:H:?1	R:R:N170	12.25	1	Yes	Yes	0	8	0	1
R:R:N198	R:R:Q173	2.64	1	Yes	No	7	2	1	1
H:H:?1	R:R:Q173	10.69	1	Yes	No	0	2	0	1
R:R:G194	R:R:Y195	2.9	1	Yes	Yes	3	4	2	1
R:R:D219	R:R:G194	5.03	1	Yes	Yes	3	3	2	2
R:R:D219	R:R:Y195	17.24	1	Yes	Yes	3	4	2	1
R:R:G222	R:R:Y195	2.9	1	No	Yes	3	4	2	1
R:R:K244	R:R:Y195	5.97	1	Yes	Yes	3	4	2	1
H:H:?1	R:R:Y195	4.18	1	Yes	Yes	0	4	0	1
R:R:G199	R:R:N198	3.39	0	No	Yes	7	7	2	1
R:R:G223	R:R:N198	3.39	1	No	Yes	7	7	2	1
H:H:?1	R:R:N198	24.5	1	Yes	Yes	0	7	0	1
R:R:D219	R:R:K244	4.15	1	Yes	Yes	3	3	2	2
R:R:G222	R:R:K244	5.23	1	No	Yes	3	3	2	2
H:H:?1	H:H:?2	38.55	1	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	13.95
Average Nodes In Shell	21.00
Average Hubs In Shell	12.00
Average Links In Shell	35.00
Average Links Mediated by Hubs In Shell	35.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7T9M
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
W:W:S31	W:W:Y102	7.63	1	No	Yes	0	0	2	2
W:W:R104	W:W:S31	3.95	1	Yes	No	0	0	1	2
W:W:D100	W:W:Y32	17.24	1	Yes	Yes	0	0	2	2
W:W:R104	W:W:Y32	5.14	1	Yes	Yes	0	0	1	2
W:W:D100	W:W:R104	15.48	1	Yes	Yes	0	0	2	1
W:W:R104	W:W:Y102	9.26	1	Yes	Yes	0	0	1	2
H:H:?1	W:W:Y102	3.14	1	Yes	Yes	0	0	1	2
H:H:?1	W:W:R104	4.33	1	Yes	Yes	0	0	1	1
H:H:?2	W:W:R104	8.67	1	No	Yes	0	0	0	1
R:R:N170	R:R:Q173	10.56	1	Yes	No	8	2	2	2
R:R:N170	R:R:N198	8.17	1	Yes	Yes	8	7	2	2
H:H:?1	R:R:N170	12.25	1	Yes	Yes	0	8	1	2
R:R:N198	R:R:Q173	2.64	1	Yes	No	7	2	2	2
H:H:?1	R:R:Q173	10.69	1	Yes	No	0	2	1	2
H:H:?1	R:R:Y195	4.18	1	Yes	Yes	0	4	1	2
H:H:?1	R:R:N198	24.5	1	Yes	Yes	0	7	1	2
H:H:?1	H:H:?2	38.55	1	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	23.61
Average Nodes In Shell	11.00
Average Hubs In Shell	8.00
Average Links In Shell	17.00
Average Links Mediated by Hubs In Shell	17.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7T9M
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:P126	R:R:T150	3.5	0	No	No	5	3	2	1
H:H:?3	R:R:T150	5.26	27	No	No	0	3	0	1
R:R:E178	R:R:N177	3.94	27	No	No	5	5	1	1
H:H:?3	R:R:N177	30.62	27	No	No	0	5	0	1
H:H:?3	R:R:E178	10.64	27	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.51
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7T9M
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F37	R:R:S53	3.96	No	No	1	5	2	1
H:H:?4	R:R:P52	2.93	No	No	0	3	0	1
H:H:?4	R:R:S53	4.02	No	No	0	5	0	1
R:R:K102	R:R:N77	4.2	No	No	4	8	2	1
H:H:?4	R:R:N77	20.82	No	No	0	8	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	9.26
Average Nodes In Shell	6.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7T9M
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N113	R:R:Q90	3.96	26	No	No	4	4	1	1
R:R:Q90	R:R:T115	4.25	26	No	No	4	4	1	2
H:H:?5	R:R:Q90	3.56	26	No	No	0	4	0	1
H:H:?5	R:R:N113	25.72	26	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.64
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7T9N

Protein

Glycoprotein hormone

TSH

Homo sapiens

M22 Fab

PubChem 644078

Gs/Beta1/Gamma2

2.9

2022-08-03

10.1038/s41586-022-05159-1

A 2D representation of the interactions of NAG in 7T9N
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N170	R:R:V169	7.39	23	No	No	8	5	1	2
R:R:N170	R:R:N198	9.54	23	No	Yes	8	7	1	1
H:H:?1	R:R:N170	7.35	23	Yes	No	0	8	0	1
R:R:N198	R:R:Q173	9.24	23	Yes	No	7	2	1	1
R:R:G199	R:R:Q173	3.29	23	No	No	7	2	2	1
H:H:?1	R:R:Q173	11.87	23	Yes	No	0	2	0	1
R:R:N198	R:R:Y195	3.49	23	Yes	Yes	7	4	1	1
R:R:D219	R:R:Y195	6.9	0	No	Yes	3	4	2	1
R:R:G222	R:R:Y195	4.35	0	No	Yes	3	4	2	1
H:H:?1	R:R:Y195	5.23	23	Yes	Yes	0	4	0	1
R:R:G199	R:R:N198	3.39	23	No	Yes	7	7	2	1
R:R:G223	R:R:N198	3.39	0	No	Yes	7	7	2	1
H:H:?1	R:R:N198	30.62	23	Yes	Yes	0	7	0	1
R:R:G199	R:R:Y225	8.69	23	No	No	7	4	2	1
R:R:K201	R:R:Y225	4.78	0	No	No	4	4	2	1
H:H:?1	R:R:Y225	3.14	23	Yes	No	0	4	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	11.64
Average Nodes In Shell	12.00
Average Hubs In Shell	3.00
Average Links In Shell	16.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7T9N
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?2	R:R:T150	10.52	No	No	0	3	0	1
H:H:?2	R:R:N177	33.07	No	No	0	5	0	1
H:H:?2	R:R:E178	11.82	No	No	0	5	0	1
R:R:P126	R:R:T150	1.75	No	No	5	3	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.47
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7T9N
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:S53	16.07	No	No	0	5	0	1
H:H:?3	R:R:P76	10.25	No	No	0	5	0	1
H:H:?3	R:R:N77	39.19	No	No	0	8	0	1
R:R:L75	R:R:P76	1.64	No	No	6	5	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	21.84
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7TD3

Lipid

Lysophospholipid (S1P)

S1P1

Homo sapiens

S1P

Gi1/Beta1/Gamma2

2022-02-09

10.1038/s41467-022-28417-2

A 2D representation of the interactions of NAG in 7TD3
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L35	R:R:N30	5.49	25	Yes	No	6	9	1	1
H:H:?1	R:R:N30	28.17	25	No	No	0	9	0	1
R:R:I37	R:R:L35	4.28	0	No	Yes	1	6	2	1
R:R:L35	R:R:Y110	4.69	25	Yes	Yes	6	5	1	2
H:H:?1	R:R:L35	3.7	25	No	Yes	0	6	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	15.94
Average Nodes In Shell	5.00
Average Hubs In Shell	2.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7TD4

Lipid

Lysophospholipid (S1P)

S1P1

Homo sapiens

Siponimod

Gi1/Beta1/Gamma2

2.6

2022-02-09

10.1038/s41467-022-28417-2

A 2D representation of the interactions of NAG in 7TD4
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L35	R:R:N30	5.49	27	No	No	6	9	1	1
H:H:?1	R:R:N30	26.95	27	No	No	0	9	0	1
H:H:?1	R:R:L35	4.94	27	No	No	0	6	0	1
R:R:L35	R:R:V26	1.49	27	No	No	6	6	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.95
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7TYF

Peptide

Calcitonin

CT (AMY1)

Homo sapiens

Amylin

Gs/Beta1/Gamma2; RAMP1

2.2

2022-03-23

10.1126/science.abm9609

A 2D representation of the interactions of NAG in 7TYF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Y65	R:R:Y71	29.79	0	Yes	No	3	3	2	1
R:R:N73	R:R:Y71	8.14	31	No	No	4	3	1	1
H:H:?1	R:R:Y71	4.18	31	No	No	0	3	0	1
H:H:?1	R:R:N73	29.4	31	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	16.79
Average Nodes In Shell	4.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7TYF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?38	R:R:W128	14.19	1	Yes	Yes	0	5	2	1
R:R:E106	R:R:M133	5.41	1	Yes	Yes	4	5	2	1
R:R:E106	R:R:F137	7	1	Yes	No	4	1	2	2
R:R:N130	R:R:T109	11.7	0	No	No	8	5	1	2
R:R:H121	R:R:P122	6.1	1	Yes	No	4	5	1	2
R:R:E123	R:R:H121	18.46	0	No	Yes	4	4	2	1
R:R:H121	R:R:W128	6.35	1	Yes	Yes	4	5	1	1
H:H:?2	R:R:H121	4.59	1	Yes	Yes	0	4	0	1
H:H:?2	R:R:W128	10.16	1	Yes	Yes	0	5	0	1
H:H:?2	R:R:N130	25.72	1	Yes	No	0	8	0	1
R:R:M133	R:R:T132	3.01	1	Yes	No	5	6	1	1
H:H:?2	R:R:T132	9.2	1	Yes	No	0	6	0	1
R:R:F137	R:R:M133	9.95	1	No	Yes	1	5	2	1
H:H:?2	R:R:M133	7.57	1	Yes	Yes	0	5	0	1
L:L:G33	R:R:W128	2.81	0	No	Yes	0	5	2	1
R:R:F119	R:R:H121	2.26	0	No	Yes	4	4	2	1
R:R:A136	R:R:M133	1.61	0	No	Yes	2	5	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	11.45
Average Nodes In Shell	15.00
Average Hubs In Shell	6.00
Average Links In Shell	17.00
Average Links Mediated by Hubs In Shell	16.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7TYI

Peptide

Calcitonin

Homo sapiens

Amylin

Gs/Beta1/Gamma2

3.3

2022-03-30

10.1126/science.abm9609

A 2D representation of the interactions of NAG in 7TYI
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:V32	R:R:W128	3.68	0	No	Yes	0	5	2	1
L:L:V32	R:R:T132	3.17	0	No	No	0	6	2	1
R:R:H121	R:R:W128	7.41	0	Yes	Yes	4	5	2	1
R:R:N130	R:R:W128	5.65	17	No	Yes	8	5	1	1
H:H:?1	R:R:W128	3.05	17	Yes	Yes	0	5	0	1
R:R:N130	R:R:T132	5.85	17	No	No	8	6	1	1
H:H:?1	R:R:N130	28.17	17	Yes	No	0	8	0	1
H:H:?1	R:R:T132	3.94	17	Yes	No	0	6	0	1
H:H:?1	R:R:M133	3.78	17	Yes	No	0	5	0	1
R:R:F119	R:R:W128	3.01	0	No	Yes	4	5	2	1
L:L:G33	R:R:W128	2.81	0	No	Yes	0	5	2	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	9.74
Average Nodes In Shell	9.00
Average Hubs In Shell	3.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7TYI
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?2	R:R:N73	34.3	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	34.30
Average Nodes In Shell	2.00
Average Hubs In Shell	0.00
Average Links In Shell	1.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7TYN

Peptide

Calcitonin

Homo sapiens

Calcitonin-1

Gs/Beta1/Gamma2

2.6

2022-03-30

10.1126/science.abm9609

A 2D representation of the interactions of NAG in 7TYN
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:G28	R:R:W128	4.22	0	No	Yes	0	5	2	1
L:L:?33	R:R:W128	5.68	2	Yes	Yes	0	5	2	1
R:R:N130	R:R:T109	5.85	2	Yes	No	8	5	1	2
H:H:?1	R:R:F119	7.6	2	Yes	No	0	4	0	1
R:R:H121	R:R:W128	11.64	0	No	Yes	4	5	2	1
R:R:N130	R:R:W128	5.65	2	Yes	Yes	8	5	1	1
H:H:?1	R:R:W128	4.06	2	Yes	Yes	0	5	0	1
R:R:N130	R:R:T132	8.77	2	Yes	No	8	6	1	2
H:H:?1	R:R:N130	24.5	2	Yes	Yes	0	8	0	1
H:H:?1	R:R:M133	3.78	2	Yes	No	0	5	0	1
R:R:K107	R:R:M133	2.88	0	No	No	3	5	2	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	9.98
Average Nodes In Shell	11.00
Average Hubs In Shell	4.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7TYN
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Y65	R:R:Y71	49.64	18	No	No	3	3	1	1
R:R:D84	R:R:Y65	13.79	0	No	No	4	3	2	1
H:H:?2	R:R:Y65	20.91	18	No	No	0	3	0	1
H:H:?2	R:R:Y71	19.87	18	No	No	0	3	0	1
H:H:?2	R:R:N73	30.62	18	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	23.80
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7TYO

Peptide

Calcitonin

Homo sapiens

Calcitonin

Gs/Beta1/Gamma2

2.7

2022-03-23

10.1126/science.abm9609

A 2D representation of the interactions of NAG in 7TYO
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:I27	R:R:T132	3.04	0	No	Yes	0	6	2	1
R:R:E106	R:R:M133	9.47	0	No	Yes	4	5	2	1
R:R:N130	R:R:T109	8.77	14	Yes	No	8	5	1	2
R:R:N130	R:R:W128	7.91	14	Yes	No	8	5	1	1
H:H:?1	R:R:W128	4.06	14	Yes	No	0	5	0	1
R:R:N130	R:R:T132	10.24	14	Yes	Yes	8	6	1	1
H:H:?1	R:R:N130	25.72	14	Yes	Yes	0	8	0	1
R:R:M133	R:R:T132	4.52	14	Yes	Yes	5	6	1	1
H:H:?1	R:R:T132	17.09	14	Yes	Yes	0	6	0	1
R:R:F137	R:R:M133	4.98	0	No	Yes	1	5	2	1
H:H:?1	R:R:M133	3.78	14	Yes	Yes	0	5	0	1
L:L:A31	R:R:W128	2.59	0	No	No	0	5	2	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	12.66
Average Nodes In Shell	10.00
Average Hubs In Shell	4.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7TYW

Peptide

Calcitonin

CT (AMY1)

Homo sapiens

Calcitonin-1

Gs/Beta1/Gamma2; RAMP1

2022-03-23

10.1126/science.abm9609

A 2D representation of the interactions of NAG in 7TYW
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?33	R:R:W128	8.51	2	Yes	Yes	0	5	2	1
R:R:E106	R:R:M133	4.06	0	No	No	4	5	2	1
R:R:N130	R:R:T109	5.85	2	Yes	No	8	5	1	2
R:R:F119	R:R:W128	15.03	2	No	Yes	4	5	1	1
H:H:?1	R:R:F119	6.52	2	Yes	No	0	4	0	1
R:R:H121	R:R:W128	6.35	0	No	Yes	4	5	2	1
R:R:N130	R:R:W128	4.52	2	Yes	Yes	8	5	1	1
H:H:?1	R:R:W128	7.11	2	Yes	Yes	0	5	0	1
R:R:N130	R:R:T132	7.31	2	Yes	No	8	6	1	1
R:R:M133	R:R:N130	4.21	2	No	Yes	5	8	1	1
H:H:?1	R:R:N130	24.5	2	Yes	Yes	0	8	0	1
H:H:?1	R:R:T132	3.94	2	Yes	No	0	6	0	1
H:H:?1	R:R:M133	10.09	2	Yes	No	0	5	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	10.43
Average Nodes In Shell	10.00
Average Hubs In Shell	4.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7TYW
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:R91	H:H:?2	3.25	0	No	Yes	3	0	1	0
R:R:Y65	R:R:Y71	29.79	29	No	No	3	3	1	1
H:H:?2	R:R:Y65	14.64	29	Yes	No	0	3	0	1
H:H:?2	R:R:Y71	21.96	29	Yes	No	0	3	0	1
H:H:?2	R:R:N73	34.3	29	Yes	No	0	4	0	1
R:R:N73	R:R:R74	2.41	0	No	Yes	4	4	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.54
Average Nodes In Shell	6.00
Average Hubs In Shell	2.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7TYX

Peptide

Calcitonin

CT (AMY2)

Homo sapiens

Amylin

Gs/Beta1/Gamma2; RAMP2

2.55

2022-03-30

10.1126/science.abm9609

A 2D representation of the interactions of NAG in 7TYX
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N125	R:R:R126	4.82	0	No	No	7	4	1	2
H:H:?1	R:R:N125	30.62	0	No	No	0	7	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	30.62
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7TYX
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?38	R:R:W128	11.35	1	No	Yes	0	5	2	1
R:R:N130	R:R:T109	5.85	1	Yes	No	8	5	1	2
R:R:F119	R:R:W128	4.01	0	No	Yes	4	5	2	1
R:R:H121	R:R:W128	19.04	1	Yes	Yes	4	5	2	1
R:R:N130	R:R:W128	11.3	1	Yes	Yes	8	5	1	1
H:H:?2	R:R:W128	6.1	1	No	Yes	0	5	0	1
R:R:N130	R:R:T132	7.31	1	Yes	No	8	6	1	2
H:H:?2	R:R:N130	25.72	1	No	Yes	0	8	0	1
H:H:?2	R:R:M133	3.78	1	No	No	0	5	0	1
R:R:E106	R:R:M133	2.71	27	Yes	No	4	5	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	11.87
Average Nodes In Shell	10.00
Average Hubs In Shell	4.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7TYX
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Y65	R:R:Y71	15.89	0	No	Yes	3	3	2	1
R:R:N73	R:R:Y71	6.98	26	No	Yes	4	3	1	1
R:R:D84	R:R:Y71	13.79	0	No	Yes	4	3	2	1
H:H:?3	R:R:Y71	12.55	26	No	Yes	0	3	0	1
H:H:?3	R:R:N73	23.27	26	No	No	0	4	0	1
R:R:N73	R:R:R74	1.21	26	No	No	4	4	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	17.91
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7TYY

Peptide

Calcitonin

CT (AMY2)

Homo sapiens

Calcitonin-1

Gs/Beta1/Gamma2; RAMP2

2022-03-23

10.1126/science.abm9609

A 2D representation of the interactions of NAG in 7TYY
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?33	R:R:W128	8.51	2	Yes	Yes	0	5	2	1
R:R:N130	R:R:T109	4.39	2	Yes	No	8	5	1	2
R:R:H121	R:R:W128	7.41	0	No	Yes	4	5	2	1
R:R:N130	R:R:W128	11.3	2	Yes	Yes	8	5	1	1
H:H:?1	R:R:W128	6.1	2	No	Yes	0	5	0	1
R:R:N130	R:R:T132	4.39	2	Yes	No	8	6	1	2
H:H:?1	R:R:N130	24.5	2	No	Yes	0	8	0	1
H:H:?1	R:R:M133	5.04	2	No	No	0	5	0	1
L:L:T31	R:R:W128	2.43	0	Yes	Yes	0	5	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	11.88
Average Nodes In Shell	9.00
Average Hubs In Shell	4.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7TZF

Peptide

Calcitonin

CT (AMY3)

Homo sapiens

Amylin

Gs/Beta1/Gamma2; RAMP3

2.4

2022-03-23

10.1126/science.abm9609

A 2D representation of the interactions of NAG in 7TZF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:E67	R:R:R45	16.28	No	No	4	7	1	2
E:E:E67	H:H:?1	11.82	No	No	4	0	1	0
E:E:N71	H:H:?1	29.4	No	No	4	0	1	0
E:E:M75	E:E:N71	1.4	No	No	1	4	2	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	20.61
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7TZF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?38	R:R:W128	11.35	0	No	Yes	0	5	2	1
R:R:N130	R:R:T109	8.77	7	Yes	No	8	5	1	2
R:R:F119	R:R:W128	4.01	0	No	Yes	4	5	2	1
R:R:H121	R:R:W128	17.98	7	Yes	Yes	4	5	2	1
R:R:N130	R:R:W128	12.43	7	Yes	Yes	8	5	1	1
H:H:?2	R:R:W128	7.11	7	Yes	Yes	0	5	0	1
R:R:N130	R:R:T132	8.77	7	Yes	No	8	6	1	1
H:H:?2	R:R:N130	22.05	7	Yes	Yes	0	8	0	1
H:H:?2	R:R:T132	3.94	7	Yes	No	0	6	0	1
H:H:?2	R:R:M133	7.57	7	Yes	No	0	5	0	1
R:R:F137	R:R:M133	2.49	22	Yes	No	1	5	2	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	10.17
Average Nodes In Shell	10.00
Average Hubs In Shell	5.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7TZF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:P87	H:H:?3	4.39	No	No	5	0	1	0
R:R:Y65	R:R:Y71	19.86	No	No	3	3	2	1
H:H:?3	R:R:Y71	7.32	No	No	0	3	0	1
H:H:?3	R:R:N73	29.4	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.70
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7TZF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K120	R:R:N125	5.6	0	No	No	1	7	2	1
H:H:?4	R:R:N125	30.62	0	No	No	0	7	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	30.62
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7UTZ

Protein

Glycoprotein hormone

TSH

Homo sapiens

TR1402

PubChem 644078

Gs/Beta1/Gamma2

2.4

2022-08-03

10.1038/s41586-022-05159-1

A 2D representation of the interactions of NAG in 7UTZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
L:L:I25	L:L:N78	7.08	1	No	Yes	1	1
H:H:?1	L:L:I25	5.09	1	No	No	0	1
L:L:N78	L:L:V68	4.43	1	Yes	No	1	2
H:H:?1	L:L:N78	25.72	1	No	Yes	0	1
L:L:I25	M:M:N37	2.83	1	No	Yes	1	2
L:L:N66	L:L:N78	2.72	0	No	Yes	2	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	15.40
Average Nodes In Shell	6.00
Average Hubs In Shell	2.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7UTZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
L:L:K44	L:L:Q50	9.49	24	No	No	1	2
L:L:K44	L:L:N52	9.79	24	No	No	1	1
H:H:?2	L:L:K44	3.77	24	No	No	0	1
L:L:N52	M:M:Y59	6.98	24	No	No	1	1
H:H:?2	L:L:N52	28.17	24	No	No	0	1
M:M:F57	M:M:Y59	6.19	0	Yes	No	2	1
H:H:?2	M:M:Y59	14.64	24	No	No	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.53
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7UTZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
M:M:N23	M:M:T8	4.39	0	No	No	0	0	1	2
H:H:?3	M:M:N23	30.62	0	No	No	0	0	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	30.62
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7UTZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H70	R:R:H95	8.36	19	No	No	4	5	2	2
R:R:H70	R:R:Y98	3.27	19	No	Yes	4	2	2	1
R:R:H95	R:R:Y98	13.07	19	No	Yes	5	2	2	1
R:R:N99	R:R:Y98	6.98	19	No	Yes	5	2	1	1
R:R:K123	R:R:Y98	3.58	0	No	Yes	4	2	2	1
H:H:?4	R:R:Y98	4.18	19	No	Yes	0	2	0	1
H:H:?4	R:R:N99	33.07	19	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	18.62
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7UTZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N77	R:R:P76	6.52	0	No	No	8	5	1	2
H:H:?5	R:R:N77	26.95	0	No	No	0	8	0	1
R:R:K102	R:R:S101	3.06	0	No	No	4	4	1	2
H:H:?5	R:R:S53	2.68	0	No	No	0	5	0	1
H:H:?5	R:R:K102	2.52	0	No	No	0	4	0	1
R:R:P51	R:R:S53	1.78	15	Yes	No	5	5	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	10.72
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7UTZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N170	R:R:V169	2.96	26	Yes	No	8	5	1	2
R:R:N170	R:R:Q173	15.85	26	Yes	No	8	2	1	1
R:R:N170	R:R:N198	5.45	26	Yes	Yes	8	7	1	1
H:H:?6	R:R:N170	11.02	26	No	Yes	0	8	0	1
R:R:N198	R:R:Q173	6.6	26	Yes	No	7	2	1	1
H:H:?6	R:R:Q173	10.69	26	No	No	0	2	0	1
R:R:N198	R:R:Y195	3.49	26	Yes	No	7	4	1	2
R:R:G199	R:R:N198	3.39	0	No	Yes	7	7	2	1
R:R:G223	R:R:N198	5.09	0	No	Yes	7	7	2	1
H:H:?6	R:R:N198	24.5	26	No	Yes	0	7	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	15.40
Average Nodes In Shell	8.00
Average Hubs In Shell	2.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7UTZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?7	R:R:T150	5.26	33	No	No	0	3	0	1
R:R:E178	R:R:I152	6.83	33	Yes	No	5	3	1	2
R:R:E178	R:R:N177	3.94	33	Yes	No	5	5	1	1
H:H:?7	R:R:N177	29.4	33	No	No	0	5	0	1
R:R:E178	R:R:K201	4.05	33	Yes	No	5	4	1	2
H:H:?7	R:R:E178	17.73	33	No	Yes	0	5	0	1
R:R:P126	R:R:T150	1.75	0	No	No	5	3	2	1
R:R:L127	R:R:T150	1.47	0	No	No	4	3	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	17.46
Average Nodes In Shell	8.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7WI6

Aminoacid

Metabotropic glutamate

mGlu3; mGlu3

Homo sapiens

LY341495

3.71

2022-03-16

10.1038/s41422-022-00623-z

A 2D representation of the interactions of NAG in 7WI6
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N209	R:R:R206	12.05	0	No	No	4	5	1	2
H:H:?1	R:R:N209	23.27	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	23.27
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7WI6
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N209	S:S:R206	12.05	0	No	No	4	5	1	2
H:H:?2	S:S:N209	23.27	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	23.27
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7WI8

Aminoacid

Metabotropic glutamate

mGlu3; mGlu3

Homo sapiens

LY341495

4.17

2022-03-16

10.1038/s41422-022-00623-z

A 2D representation of the interactions of NAG in 7WI8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N209	R:R:R206	10.85	44	No	No	4	5	1	1
R:R:R206	R:R:R237	12.79	44	No	No	5	4	1	2
H:H:?1	R:R:R206	11.92	44	No	No	0	5	0	1
H:H:?1	R:R:N209	28.17	44	No	No	0	4	0	1
R:R:N209	R:R:T211	1.46	44	No	No	4	7	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	20.05
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7WI8
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N209	S:S:R206	10.85	58	No	No	4	5	1	1
S:S:R206	S:S:R237	12.79	58	No	No	5	4	1	2
H:H:?2	S:S:R206	11.92	58	No	No	0	5	0	1
H:H:?2	S:S:N209	28.17	58	No	No	0	4	0	1
S:S:N209	S:S:T211	1.46	58	No	No	4	7	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	20.05
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7WIH

Aminoacid

Metabotropic glutamate

mGlu3; mGlu3

Homo sapiens

LY2794193

3.68

2022-03-16

10.1038/s41422-022-00623-z

A 2D representation of the interactions of NAG in 7WIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N209	R:R:R206	7.23	0	No	No	4	5	1	2
H:H:?1	R:R:N209	23.27	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	23.27
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7WIH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N209	S:S:R206	7.23	0	No	No	4	5	1	2
H:H:?2	S:S:N209	23.27	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	23.27
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7XW5

Protein

Glycoprotein hormone

TSH

Homo sapiens

TSH

ML109

Gs/Beta1/Gamma2

2.96

2022-08-24

10.1038/s41586-022-05173-3

A 2D representation of the interactions of NAG in 7XW5
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N170	R:R:V169	5.91	22	Yes	No	8	5	1	1
H:H:?1	R:R:V169	3.99	22	Yes	No	0	5	0	1
R:R:N170	R:R:Q173	10.56	22	Yes	Yes	8	2	1	1
R:R:N170	R:R:N198	8.17	22	Yes	Yes	8	7	1	1
H:H:?1	R:R:N170	15.92	22	Yes	Yes	0	8	0	1
R:R:N198	R:R:Q173	9.24	22	Yes	Yes	7	2	1	1
R:R:G199	R:R:Q173	3.29	0	No	Yes	7	2	2	1
H:H:?1	R:R:Q173	10.69	22	Yes	Yes	0	2	0	1
R:R:N198	R:R:Y195	3.49	22	Yes	Yes	7	4	1	1
R:R:D219	R:R:Y195	5.75	0	No	Yes	3	4	2	1
H:H:?1	R:R:Y195	9.41	22	Yes	Yes	0	4	0	1
R:R:G223	R:R:N198	3.39	0	No	Yes	7	7	2	1
H:H:?1	R:R:N198	24.5	22	Yes	Yes	0	7	0	1
R:R:G222	R:R:Y195	2.9	0	No	Yes	3	4	2	1
R:R:Q193	R:R:V169	2.87	0	No	No	5	5	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	12.90
Average Nodes In Shell	11.00
Average Hubs In Shell	5.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	14.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7XW5
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N177	R:R:T150	4.39	4	No	No	5	3	1	1
H:H:?2	R:R:T150	5.26	4	No	No	0	3	0	1
R:R:E178	R:R:I152	9.56	4	Yes	No	5	3	1	2
R:R:C176	R:R:E178	3.04	4	No	Yes	6	5	2	1
R:R:E178	R:R:N177	3.94	4	Yes	No	5	5	1	1
H:H:?2	R:R:N177	26.95	4	No	No	0	5	0	1
H:H:?2	R:R:E178	15.37	4	No	Yes	0	5	0	1
R:R:P126	R:R:T150	1.75	0	No	No	5	3	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	15.86
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7XW5
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H70	R:R:H95	7.17	8	Yes	Yes	4	5	2	2
R:R:H70	R:R:Y98	4.36	8	Yes	Yes	4	2	2	1
R:R:H95	R:R:Y98	13.07	8	Yes	Yes	5	2	2	1
R:R:H95	R:R:K123	5.24	8	Yes	No	5	4	2	2
R:R:N99	R:R:Y98	8.14	8	No	Yes	5	2	1	1
R:R:K123	R:R:Y98	7.17	8	No	Yes	4	2	2	1
H:H:?3	R:R:Y98	10.46	8	No	Yes	0	2	0	1
H:H:?3	R:R:N99	28.17	8	No	No	0	5	0	1
H:H:?3	R:R:S101	2.68	8	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	13.77
Average Nodes In Shell	7.00
Average Hubs In Shell	3.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7XW5
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?4	R:R:N77	25.72	0	No	No	0	8	0	1
R:R:N77	R:R:P76	1.63	0	No	No	8	5	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	25.72
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7XW5
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
M:M:E14	M:M:P24	4.72	0	No	No	2	1
H:H:?5	M:M:P24	4.39	45	Yes	No	0	1
M:M:I25	M:M:V68	3.07	45	No	No	1	2
M:M:I25	M:M:N78	5.66	45	No	No	1	1
H:H:?5	M:M:I25	3.82	45	Yes	No	0	1
H:H:?5	M:M:L26	3.7	45	Yes	No	0	1
M:M:S64	M:M:T80	4.8	0	No	No	2	1
H:H:?5	M:M:N78	23.27	45	Yes	No	0	1
H:H:?5	M:M:T80	3.94	45	Yes	No	0	1
M:M:N66	M:M:N78	2.72	0	No	No	2	1
M:M:A23	M:M:P24	1.87	0	No	No	2	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	7.82
Average Nodes In Shell	11.00
Average Hubs In Shell	1.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7XW5
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
L:L:Y79	M:M:N52	4.65	26	Yes	No	1	1
H:H:?6	M:M:N52	25.72	26	No	No	0	1
L:L:F77	L:L:Y79	6.19	26	Yes	Yes	2	1
L:L:F77	L:L:P98	4.33	26	Yes	No	2	2
L:L:F77	L:L:Y112	9.28	26	Yes	No	2	1
L:L:P98	L:L:Y79	5.56	26	No	Yes	2	1
H:H:?6	L:L:Y79	30.32	26	No	Yes	0	1
L:L:N109	L:L:Y112	15.12	0	No	No	2	1
H:H:?6	L:L:Y112	3.14	26	No	No	0	1
M:M:K44	M:M:N52	2.8	0	No	No	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	19.73
Average Nodes In Shell	8.00
Average Hubs In Shell	2.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7XW5
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
H:H:?7	L:L:E26	10.64	No	No	0	1
H:H:?7	L:L:N43	33.07	No	No	0	1
L:L:N43	L:L:T28	1.46	No	No	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	21.86
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7XW6

Protein

Glycoprotein hormone

TSH

Homo sapiens

M22 Fab

ML109

Gs/Beta1/Gamma2

2.78

2022-08-17

10.1038/s41586-022-05173-3

A 2D representation of the interactions of NAG in 7XW6
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N170	R:R:V169	5.91	27	Yes	No	8	5	1	2
R:R:N170	R:R:Q173	10.56	27	Yes	No	8	2	1	1
R:R:N170	R:R:N198	5.45	27	Yes	Yes	8	7	1	1
H:H:?1	R:R:N170	12.25	27	Yes	Yes	0	8	0	1
R:R:G199	R:R:Q173	3.29	0	No	No	7	2	2	1
H:H:?1	R:R:Q173	8.31	27	Yes	No	0	2	0	1
R:R:D219	R:R:Y195	12.64	0	No	No	3	4	2	1
R:R:G222	R:R:Y195	2.9	0	No	No	3	4	2	1
H:H:?1	R:R:Y195	7.32	27	Yes	No	0	4	0	1
R:R:G199	R:R:N198	3.39	0	No	Yes	7	7	2	1
R:R:G223	R:R:N198	3.39	0	No	Yes	7	7	2	1
H:H:?1	R:R:N198	24.5	27	Yes	Yes	0	7	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	13.10
Average Nodes In Shell	10.00
Average Hubs In Shell	3.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7XW6
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:P126	R:R:T150	3.5	0	No	No	5	3	2	1
H:H:?2	R:R:Y148	3.14	40	Yes	No	0	4	0	1
H:H:?2	R:R:T150	6.57	40	Yes	No	0	3	0	1
R:R:E178	R:R:N177	3.94	40	No	No	5	5	1	1
H:H:?2	R:R:N177	29.4	40	Yes	No	0	5	0	1
H:H:?2	R:R:E178	8.27	40	Yes	No	0	5	0	1
R:R:E178	R:R:K201	2.7	40	No	No	5	4	1	2
R:R:L127	R:R:T150	1.47	0	No	No	4	3	2	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	11.84
Average Nodes In Shell	8.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7XW6
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H70	R:R:H95	15.53	21	No	Yes	4	5	2	2
R:R:H70	R:R:Y98	4.36	21	No	Yes	4	2	2	1
R:R:H95	R:R:Y98	14.16	21	Yes	Yes	5	2	2	1
R:R:H95	R:R:K123	3.93	21	Yes	Yes	5	4	2	2
R:R:N99	R:R:Y98	10.47	21	No	Yes	5	2	1	1
R:R:K123	R:R:Y98	9.55	21	Yes	Yes	4	2	2	1
R:R:E124	R:R:Y98	13.47	21	No	Yes	4	2	2	1
H:H:?3	R:R:Y98	10.46	21	No	Yes	0	2	0	1
H:H:?3	R:R:N99	25.72	21	No	No	0	5	0	1
R:R:E124	R:R:K123	16.2	21	No	Yes	4	4	2	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	18.09
Average Nodes In Shell	7.00
Average Hubs In Shell	3.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 7XW6
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D36	R:R:Q55	15.66	0	No	No	3	4	2	1
R:R:F37	R:R:S53	11.89	37	Yes	No	1	5	2	1
H:H:?4	R:R:S53	4.02	38	No	No	0	5	0	1
R:R:N77	R:R:Q55	13.2	38	No	No	8	4	1	1
H:H:?4	R:R:Q55	5.94	38	No	No	0	4	0	1
H:H:?4	R:R:N77	28.17	38	No	No	0	8	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	12.71
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7YXA

Lipid

Lysophospholipid (S1P)

S1P5

Homo sapiens

ONO-5430608

2.2

2022-08-10

10.1038/s41467-022-32447-1

A 2D representation of the interactions of NAG in 7YXA
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:R7	4.33	1	No	No	0	6	0	1
R:R:L25	R:R:V16	5.96	1	Yes	No	6	2	1	2
R:R:L101	R:R:V16	4.47	1	Yes	No	6	2	2	2
R:R:L25	R:R:N20	5.49	1	Yes	No	6	8	1	1
H:H:?1	R:R:N20	22.05	1	No	No	0	8	0	1
R:R:L25	R:R:R29	6.07	1	Yes	No	6	2	1	2
R:R:L101	R:R:L25	4.15	1	Yes	Yes	6	6	2	1
H:H:?1	R:R:L25	6.17	1	No	Yes	0	6	0	1
R:R:P8	R:R:R7	1.44	0	No	No	6	6	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	10.85
Average Nodes In Shell	8.00
Average Hubs In Shell	2.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7ZBC

Sensory

Opsins

Rhodopsin

Bos Taurus

11-cis-Retinal

1.8

2023-03-29

10.1038/s41586-023-05863-6

A 2D representation of the interactions of NAG in 7ZBC
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?401	R:R:M1	6.37	6	No	No	0	6	1	2
R:R:D282	R:R:N2	14.81	6	No	No	2	6	1	1
H:H:?401	R:R:N2	10.3	6	No	No	0	6	1	1
H:H:?403	R:R:N2	24.5	6	Yes	No	0	6	0	1
H:H:?403	R:R:G280	4.58	6	Yes	No	0	1	0	1
H:H:?403	R:R:D282	6.05	6	Yes	No	0	2	0	1
H:H:?401	H:H:?403	27.79	6	No	Yes	0	0	1	0

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.73
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7ZBE

Sensory

Opsins

Rhodopsin

Bos Taurus

11-cis-Retinal

1.8

2023-03-29

10.1038/s41586-023-05863-6

A 2D representation of the interactions of NAG in 7ZBE
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?401	R:R:M1	6.37	4	No	No	0	6	1	2
R:R:D282	R:R:N2	14.81	4	No	No	2	6	1	1
H:H:?401	R:R:N2	10.3	4	No	No	0	6	1	1
H:H:?403	R:R:N2	24.5	4	Yes	No	0	6	0	1
H:H:?403	R:R:D282	6.05	4	Yes	No	0	2	0	1
H:H:?401	H:H:?403	25.94	4	No	Yes	0	0	1	0
H:H:?403	R:R:G280	3.05	4	Yes	No	0	1	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.88
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7ZI0

Protein

Frizzled

SMO

Homo sapiens

SAG

Cholesterol

2022-06-15

10.1126/sciadv.abm5563

A 2D representation of the interactions of NAG in 7ZI0
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K186	R:R:N188	5.6	9	No	No	4	8	1	1
H:H:?1	R:R:K186	6.29	9	No	No	0	4	0	1
H:H:?1	R:R:N188	30.62	9	No	No	0	8	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.46
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8A6C

Sensory

Opsins

Rhodopsin

Bos Taurus

All-trans-retinal

1.8

2023-03-29

10.1038/s41586-023-05863-6

A 2D representation of the interactions of NAG in 8A6C
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?401	R:R:M1	6.37	3	No	No	0	6	1	2
R:R:D282	R:R:N2	13.46	3	No	No	2	6	1	1
H:H:?401	R:R:N2	8.24	3	No	No	0	6	1	1
H:H:?403	R:R:N2	23.27	3	Yes	No	0	6	0	1
H:H:?403	R:R:G280	3.05	3	Yes	No	0	1	0	1
H:H:?403	R:R:D282	6.05	3	Yes	No	0	2	0	1
H:H:?401	H:H:?403	25.94	3	No	Yes	0	0	1	0

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.58
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8A6D

Sensory

Opsins

Rhodopsin

Bos Taurus

All-trans-retinal

1.8

2023-03-29

10.1038/s41586-023-05863-6

A 2D representation of the interactions of NAG in 8A6D
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	5.85	1	Yes	No	7	6	1	1
R:R:T4	R:R:V20	7.93	1	No	Yes	6	6	1	1
H:H:?1	R:R:T4	3.94	1	Yes	No	0	6	0	1
R:R:V11	R:R:V20	4.81	1	No	Yes	8	6	2	1
R:R:V11	R:R:Y30	6.31	1	No	Yes	8	4	2	2
R:R:F13	R:R:V20	5.24	1	No	Yes	4	6	2	1
R:R:F13	R:R:Y30	6.19	1	No	Yes	4	4	2	2
R:R:G18	R:R:N15	5.09	1	No	Yes	3	7	1	1
R:R:N15	R:R:V20	10.35	1	Yes	Yes	7	6	1	1
H:H:?1	R:R:N15	25.72	1	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	11.36	1	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	3.99	1	Yes	Yes	0	6	0	1
H:H:?1	H:H:?2	38.55	1	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	15.66
Average Nodes In Shell	9.00
Average Hubs In Shell	4.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	14.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8A6D
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	5.85	1	Yes	No	7	6	2	2
R:R:T4	R:R:V20	7.93	1	No	Yes	6	6	2	2
H:H:?1	R:R:T4	3.94	1	Yes	No	0	6	1	2
R:R:G18	R:R:N15	5.09	1	No	Yes	3	7	2	2
R:R:N15	R:R:V20	10.35	1	Yes	Yes	7	6	2	2
H:H:?1	R:R:N15	25.72	1	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	1	2
H:H:?1	R:R:V20	3.99	1	Yes	Yes	0	6	1	2
H:H:?1	H:H:?2	38.55	1	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	38.55
Average Nodes In Shell	6.00
Average Hubs In Shell	3.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8A6D
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:G280	R:R:M1	3.49	0	No	No	1	6	1	2
H:H:?401	R:R:M1	6.37	4	No	No	0	6	1	2
R:R:D282	R:R:N2	8.08	4	No	No	2	6	1	1
H:H:?401	R:R:N2	4.12	4	No	No	0	6	1	1
H:H:?403	R:R:N2	24.5	4	Yes	No	0	6	0	1
H:H:?403	R:R:G280	4.58	4	Yes	No	0	1	0	1
H:H:?403	R:R:D282	8.47	4	Yes	No	0	2	0	1
H:H:?401	H:H:?403	16.68	4	No	Yes	0	0	1	0

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.56
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8A6E

Sensory

Opsins

Rhodopsin

Bos Taurus

All-trans-retinal

1.8

2023-03-29

10.1038/s41586-023-05863-6

A 2D representation of the interactions of NAG in 8A6E
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	5.85	2	Yes	No	7	6	1	1
R:R:T4	R:R:V20	7.93	2	No	Yes	6	6	1	1
H:H:?1	R:R:T4	3.94	2	Yes	No	0	6	0	1
R:R:V11	R:R:V20	4.81	2	No	Yes	8	6	2	1
R:R:V11	R:R:Y30	6.31	2	No	Yes	8	4	2	2
R:R:F13	R:R:V20	3.93	2	No	Yes	4	6	2	1
R:R:F13	R:R:Y30	6.19	2	No	Yes	4	4	2	2
R:R:G18	R:R:N15	5.09	2	No	Yes	3	7	1	1
R:R:N15	R:R:V20	10.35	2	Yes	Yes	7	6	1	1
H:H:?1	R:R:N15	26.95	2	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	12.62	2	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	3.99	2	Yes	Yes	0	6	0	1
H:H:?1	H:H:?2	35.24	2	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	15.24
Average Nodes In Shell	9.00
Average Hubs In Shell	4.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	14.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8A6E
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	5.85	2	Yes	No	7	6	2	2
R:R:T4	R:R:V20	7.93	2	No	Yes	6	6	2	2
H:H:?1	R:R:T4	3.94	2	Yes	No	0	6	1	2
R:R:G18	R:R:N15	5.09	2	No	Yes	3	7	2	2
R:R:N15	R:R:V20	10.35	2	Yes	Yes	7	6	2	2
H:H:?1	R:R:N15	26.95	2	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	1	2
H:H:?1	R:R:V20	3.99	2	Yes	Yes	0	6	1	2
H:H:?1	H:H:?2	35.24	2	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	35.24
Average Nodes In Shell	6.00
Average Hubs In Shell	3.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8A6E
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?401	R:R:M1	6.37	6	No	No	0	6	1	2
R:R:D282	R:R:N2	10.77	6	No	No	2	6	1	1
H:H:?401	R:R:N2	4.12	6	No	No	0	6	1	1
H:H:?403	R:R:N2	24.5	6	Yes	No	0	6	0	1
H:H:?403	R:R:G280	4.58	6	Yes	No	0	1	0	1
H:H:?403	R:R:D282	9.68	6	Yes	No	0	2	0	1
H:H:?401	H:H:?403	16.68	6	No	Yes	0	0	1	0

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.86
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8F0J

Peptide

Calcitonin

Homo Sapiens

Pramlintide analogue san45

Gs/Beta1/Gamma2

2023-08-02

10.1038/s41589-023-01393-4

A 2D representation of the interactions of NAG in 8F0J
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Y65	R:R:Y71	10.92	24	Yes	Yes	3	3	2	1
R:R:D84	R:R:Y65	6.9	24	No	Yes	4	3	2	2
R:R:N73	R:R:Y71	5.81	24	No	Yes	4	3	1	1
R:R:D84	R:R:Y71	10.34	24	No	Yes	4	3	2	1
H:H:?1	R:R:Y71	3.14	24	No	Yes	0	3	0	1
H:H:?1	R:R:N73	28.17	24	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	15.66
Average Nodes In Shell	5.00
Average Hubs In Shell	2.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8F0J
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?38	R:R:W128	8.51	0	Yes	Yes	0	5	2	1
R:R:N130	R:R:T109	7.31	8	Yes	No	8	5	1	2
R:R:F119	R:R:W128	3.01	0	No	Yes	4	5	2	1
R:R:H121	R:R:W128	23.27	8	Yes	Yes	4	5	2	1
R:R:N130	R:R:W128	9.04	8	Yes	Yes	8	5	1	1
H:H:?2	R:R:W128	10.16	8	Yes	Yes	0	5	0	1
R:R:N130	R:R:T132	8.77	8	Yes	No	8	6	1	1
H:H:?2	R:R:N130	25.72	8	Yes	Yes	0	8	0	1
R:R:M133	R:R:T132	3.01	8	No	No	5	6	1	1
H:H:?2	R:R:T132	5.26	8	Yes	No	0	6	0	1
H:H:?2	R:R:M133	5.04	8	Yes	No	0	5	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	11.54
Average Nodes In Shell	9.00
Average Hubs In Shell	5.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8F0K

Peptide

Calcitonin

CT (AMY3)

Homo Sapiens

Pramlintide analogue san385

Gs/Beta1/Gamma2; RAMP3

1.9

2023-08-02

10.1038/s41589-023-01393-4

A 2D representation of the interactions of NAG in 8F0K
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:N29	E:E:T31	5.85	24	No	No	8	7	1	1
E:E:?201	E:E:N29	28.17	24	No	No	0	8	0	1
E:E:?201	E:E:T31	5.26	24	No	No	0	7	0	1
E:E:?201	E:E:E35	7.09	24	No	No	0	3	0	1
E:E:E35	E:E:G32	3.27	0	No	No	3	3	1	2
E:E:N29	E:E:V80	2.96	24	No	Yes	8	5	1	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.51
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8F0K
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:E67	R:R:R45	13.96	2	No	No	4	7	1	2
E:E:E67	R:R:M49	6.77	2	No	Yes	4	4	1	2
E:E:?202	E:E:E67	14.18	2	Yes	No	0	4	0	1
E:E:M75	E:E:N71	4.21	2	No	No	1	4	1	1
E:E:?202	E:E:N71	24.5	2	Yes	No	0	4	0	1
E:E:E74	E:E:M75	5.41	2	No	No	5	1	2	1
E:E:?202	E:E:M75	7.57	2	Yes	No	0	1	0	1
R:R:M49	R:R:R45	9.93	2	Yes	No	4	7	2	2
E:E:?202	E:E:S68	2.68	2	Yes	No	0	2	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	12.23
Average Nodes In Shell	8.00
Average Hubs In Shell	2.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8F0K
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:N125	28.17	0	No	No	0	7	0	1
R:R:K120	R:R:N125	1.4	0	No	No	1	7	2	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	28.17
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8F0K
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E106	R:R:M133	4.06	7	Yes	No	4	5	2	1
R:R:E106	R:R:F137	3.5	7	Yes	Yes	4	1	2	2
R:R:N130	R:R:T109	5.85	7	Yes	No	8	5	1	2
R:R:H121	R:R:W128	15.87	7	Yes	Yes	4	5	2	1
R:R:N130	R:R:W128	7.91	7	Yes	Yes	8	5	1	1
H:H:?2	R:R:W128	6.1	7	Yes	Yes	0	5	0	1
R:R:N130	R:R:T132	5.85	7	Yes	No	8	6	1	2
H:H:?2	R:R:N130	24.5	7	Yes	Yes	0	8	0	1
R:R:F137	R:R:M133	4.98	7	Yes	No	1	5	2	1
H:H:?2	R:R:M133	6.31	7	Yes	No	0	5	0	1
L:L:T36	R:R:W128	2.43	0	No	Yes	0	5	2	1
H:H:?2	R:R:F119	2.17	7	Yes	No	0	4	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	9.77
Average Nodes In Shell	11.00
Average Hubs In Shell	6.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8F0K
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N73	R:R:Y71	5.81	0	No	No	4	3	1	2
H:H:?3	R:R:N73	25.72	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	25.72
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8F2A

Peptide

Calcitonin

CT (AMY3)

Homo Sapiens

Pramlintide analogue san385

Gs/Beta1/Gamma2; RAMP3

2.2

2023-08-02

10.1038/s41589-023-01393-4

A 2D representation of the interactions of NAG in 8F2A
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:N29	E:E:T31	5.85	23	No	No	8	7	1	1
E:E:G32	E:E:N29	6.79	0	No	No	3	8	2	1
E:E:?201	E:E:N29	29.4	23	No	No	0	8	0	1
E:E:?201	E:E:T31	7.89	23	No	No	0	7	0	1
E:E:L34	E:E:T31	2.95	0	No	No	5	7	2	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.64
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8F2A
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:M75	E:E:N71	8.41	26	No	No	1	4	1	1
E:E:?202	E:E:N71	30.62	26	No	No	0	4	0	1
E:E:?202	E:E:M75	15.13	26	No	No	0	1	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	22.88
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8F2A
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N73	R:R:Y71	10.47	18	No	No	4	3	1	2
R:R:D84	R:R:Y71	3.45	18	Yes	No	4	3	2	2
R:R:D84	R:R:N73	4.04	18	Yes	No	4	4	2	1
H:H:?1	R:R:N73	29.4	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	29.40
Average Nodes In Shell	4.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	2.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8F2A
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?38	R:R:W128	11.35	0	No	Yes	0	5	2	1
R:R:N130	R:R:T109	5.85	12	Yes	No	8	5	1	2
R:R:H121	R:R:W128	25.39	0	No	Yes	4	5	2	1
R:R:N130	R:R:W128	11.3	12	Yes	Yes	8	5	1	1
H:H:?2	R:R:W128	7.11	12	No	Yes	0	5	0	1
R:R:N130	R:R:T132	8.77	12	Yes	No	8	6	1	1
H:H:?2	R:R:N130	29.4	12	No	Yes	0	8	0	1
H:H:?2	R:R:T132	13.15	12	No	No	0	6	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	16.55
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8F2B

Peptide

Calcitonin

CT (AMY3)

Homo Sapiens

Pramlintide analogue san45

Gs/Beta1/Gamma2; RAMP3

2023-08-02

10.1038/s41589-023-01393-4

A 2D representation of the interactions of NAG in 8F2B
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Y65	R:R:Y71	19.86	20	Yes	Yes	3	3	2	1
R:R:D84	R:R:Y65	5.75	20	No	Yes	4	3	2	2
R:R:N73	R:R:Y71	3.49	20	No	Yes	4	3	1	1
R:R:D84	R:R:Y71	5.75	20	No	Yes	4	3	2	1
H:H:?1	R:R:Y71	12.55	20	No	Yes	0	3	0	1
H:H:?1	R:R:N73	34.3	20	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	23.42
Average Nodes In Shell	5.00
Average Hubs In Shell	2.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8F2B
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K120	R:R:N125	5.6	0	No	No	1	7	2	1
H:H:?2	R:R:N125	26.95	0	No	No	0	7	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	26.95
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8F2B
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?38	R:R:W128	5.68	1	Yes	Yes	0	5	2	1
R:R:E106	R:R:M133	4.06	16	No	No	4	5	2	1
R:R:N130	R:R:T109	5.85	1	Yes	No	8	5	1	2
R:R:H121	R:R:W128	23.27	1	Yes	Yes	4	5	2	1
R:R:N130	R:R:W128	11.3	1	Yes	Yes	8	5	1	1
H:H:?3	R:R:W128	5.08	1	Yes	Yes	0	5	0	1
R:R:N130	R:R:T132	7.31	1	Yes	No	8	6	1	1
H:H:?3	R:R:N130	26.95	1	Yes	Yes	0	8	0	1
H:H:?3	R:R:T132	6.57	1	Yes	No	0	6	0	1
H:H:?3	R:R:M133	5.04	1	Yes	No	0	5	0	1
R:R:F137	R:R:M133	2.49	0	No	No	1	5	2	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	10.91
Average Nodes In Shell	10.00
Average Hubs In Shell	5.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8FCZ

Sensory

Opsins

Rhodopsin

Bos Taurus

11-cis-Retinal

3.7

2023-08-30

10.1038/s41467-023-40911-9

A 2D representation of the interactions of NAG in 8FCZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:N2	25.72	0	Yes	No	0	6	0	1
R:R:N15	R:R:T4	5.85	2	No	No	7	6	1	2
R:R:T4	R:R:V20	9.52	2	No	Yes	6	6	2	2
R:R:N15	R:R:V20	14.78	2	No	Yes	7	6	1	2
H:H:?1	R:R:N15	26.95	0	Yes	No	0	7	0	1
H:H:?1	R:R:G18	6.1	0	Yes	No	0	3	0	1
H:H:?1	R:R:D282	7.26	0	Yes	No	0	2	0	1
H:H:?1	H:H:?2	69.38	0	Yes	No	0	0	0	1
H:H:?2	H:H:?3	60.19	9	No	No	0	0	1	2
H:H:?2	H:H:?6	10.16	9	No	No	0	0	1	2
H:H:?3	H:H:?6	26.57	9	No	No	0	0	2	2
H:H:?1	R:R:M1	2.52	0	Yes	No	0	6	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	22.99
Average Nodes In Shell	11.00
Average Hubs In Shell	2.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FCZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:N2	25.72	0	Yes	No	6	1	2
H:H:?1	R:R:N15	26.95	0	Yes	No	7	1	2
H:H:?1	R:R:G18	6.1	0	Yes	No	3	1	2
H:H:?1	R:R:D282	7.26	0	Yes	No	2	1	2
H:H:?1	H:H:?2	69.38	0	Yes	No	0	1	0
H:H:?2	H:H:?3	60.19	9	No	No	0	0	1
H:H:?2	H:H:?6	10.16	9	No	No	0	0	1
H:H:?3	H:H:?4	35.43	9	No	No	0	1	2
H:H:?3	H:H:?6	26.57	9	No	No	0	1	1
H:H:?1	R:R:M1	2.52	0	Yes	No	6	1	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	46.58
Average Nodes In Shell	10.00
Average Hubs In Shell	1.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FCZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	H:H:?4	35.43	9	No	No	0	0	2	1
H:H:?4	H:H:?5	35.55	0	No	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	35.55
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8FCZ_poly

Sensory

Opsins

Rhodopsin

Bos Taurus

11-cis-Retinal

3.7

2023-08-30

10.1038/s41467-023-40911-9

A 2D representation of the interactions of NAG in 8FCZ_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	5.85	2	Yes	No	7	6	1	2
R:R:T4	R:R:V20	9.52	2	No	Yes	6	6	2	2
R:R:F9	R:R:G6	9.03	2	Yes	No	7	6	1	2
R:R:F9	R:R:S22	9.25	2	Yes	Yes	7	5	1	2
R:R:F9	R:R:P23	11.56	2	Yes	Yes	7	5	1	2
H:H:?1	R:R:F9	3.26	2	Yes	Yes	0	7	0	1
R:R:G18	R:R:N15	3.39	2	No	Yes	3	7	1	1
R:R:N15	R:R:V20	14.78	2	Yes	Yes	7	6	1	2
H:H:?1	R:R:N15	26.95	2	Yes	Yes	0	7	0	1
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	0	1
R:R:P23	R:R:S22	3.56	2	Yes	Yes	5	5	2	2
H:H:?1	H:H:?2	33.04	2	Yes	No	0	0	0	1
H:H:?2	H:H:?3	28.17	2	No	No	0	0	1	2
H:H:?2	H:H:?6	10.16	2	No	No	0	0	1	2
H:H:?3	H:H:?6	26.57	2	No	No	0	0	2	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	17.34
Average Nodes In Shell	12.00
Average Hubs In Shell	6.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FCZ_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:F9	3.26	2	Yes	Yes	0	7	1	2
R:R:G18	R:R:N15	3.39	2	No	Yes	3	7	2	2
H:H:?1	R:R:N15	26.95	2	Yes	Yes	0	7	1	2
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	1	2
H:H:?1	H:H:?2	33.04	2	Yes	No	0	0	1	0
H:H:?2	H:H:?3	28.17	2	No	No	0	0	0	1
H:H:?2	H:H:?6	10.16	2	No	No	0	0	0	1
H:H:?3	H:H:?4	35.43	2	No	No	0	0	1	2
H:H:?3	H:H:?6	26.57	2	No	No	0	0	1	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	23.79
Average Nodes In Shell	8.00
Average Hubs In Shell	3.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FCZ_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	H:H:?4	35.43	2	No	No	0	0	2	1
H:H:?4	H:H:?5	35.55	0	No	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	35.55
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FCZ_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?7	R:R:N2	25.72	Yes	No	0	6	0	1
H:H:?7	R:R:D282	7.26	Yes	No	0	2	0	1
H:H:?7	H:H:?8	36.34	Yes	No	0	0	0	1
H:H:?8	H:H:?9	32.02	No	No	0	0	1	2
H:H:?7	R:R:M1	2.52	Yes	No	0	6	0	1
R:R:G3	R:R:N2	1.7	No	No	6	6	2	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	17.96
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FCZ_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?7	R:R:N2	25.72	Yes	No	6	1	2
H:H:?7	R:R:D282	7.26	Yes	No	2	1	2
H:H:?7	H:H:?8	36.34	Yes	No	0	1	0
H:H:?8	H:H:?9	32.02	No	No	0	0	1
H:H:?7	R:R:M1	2.52	Yes	No	6	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	34.18
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FCZ_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N15	S:S:T4	5.85	1	Yes	No	7	6	1	2
S:S:T4	S:S:V20	9.52	1	No	Yes	6	6	2	1
S:S:F9	S:S:G6	9.03	1	Yes	No	7	6	1	2
S:S:F9	S:S:S22	9.25	1	Yes	Yes	7	5	1	2
S:S:F9	S:S:P23	11.56	1	Yes	Yes	7	5	1	2
H:H:?10	S:S:F9	4.35	1	Yes	Yes	0	7	0	1
S:S:V11	S:S:V20	4.81	1	Yes	Yes	8	6	2	1
S:S:P23	S:S:V11	3.53	1	Yes	Yes	5	8	2	2
S:S:V11	S:S:Y30	3.79	1	Yes	Yes	8	4	2	2
S:S:G18	S:S:N15	3.39	1	No	Yes	3	7	1	1
S:S:N15	S:S:V20	14.78	1	Yes	Yes	7	6	1	1
H:H:?10	S:S:N15	24.5	1	Yes	Yes	0	7	0	1
H:H:?10	S:S:G18	4.58	1	Yes	No	0	3	0	1
S:S:V20	S:S:Y30	8.83	1	Yes	Yes	6	4	1	2
H:H:?10	S:S:V20	3.99	1	Yes	Yes	0	6	0	1
S:S:E25	S:S:R21	3.49	0	No	No	7	4	2	1
S:S:A26	S:S:R21	4.15	0	No	No	2	4	2	1
H:H:?10	S:S:R21	3.25	1	Yes	No	0	4	0	1
S:S:P23	S:S:S22	3.56	1	Yes	Yes	5	5	2	2
S:S:E25	S:S:S22	12.94	0	No	Yes	7	5	2	2
H:H:?10	H:H:?11	35.24	1	Yes	No	0	0	0	1
H:H:?11	H:H:?12	32.02	1	No	No	0	0	1	2
H:H:?11	H:H:?14	12.7	1	No	No	0	0	1	2
H:H:?12	H:H:?14	28.05	1	No	No	0	0	2	2
S:S:M1	S:S:N15	2.8	0	No	Yes	6	7	2	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	12.65
Average Nodes In Shell	18.00
Average Hubs In Shell	8.00
Average Links In Shell	25.00
Average Links Mediated by Hubs In Shell	20.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FCZ_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?10	S:S:F9	4.35	1	Yes	Yes	0	7	1	2
S:S:G18	S:S:N15	3.39	1	No	Yes	3	7	2	2
S:S:N15	S:S:V20	14.78	1	Yes	Yes	7	6	2	2
H:H:?10	S:S:N15	24.5	1	Yes	Yes	0	7	1	2
H:H:?10	S:S:G18	4.58	1	Yes	No	0	3	1	2
H:H:?10	S:S:V20	3.99	1	Yes	Yes	0	6	1	2
H:H:?10	S:S:R21	3.25	1	Yes	No	0	4	1	2
H:H:?10	H:H:?11	35.24	1	Yes	No	0	0	1	0
H:H:?11	H:H:?12	32.02	1	No	No	0	0	0	1
H:H:?11	H:H:?14	12.7	1	No	No	0	0	0	1
H:H:?12	H:H:?13	41.33	1	No	No	0	0	1	2
H:H:?12	H:H:?14	28.05	1	No	No	0	0	1	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	26.65
Average Nodes In Shell	10.00
Average Hubs In Shell	4.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FCZ_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?15	S:S:N2	30.62	No	No	0	6	0	1
H:H:?15	S:S:D282	4.84	No	No	0	2	0	1
H:H:?15	H:H:?16	35.24	No	No	0	0	0	1
S:S:G3	S:S:N2	1.7	No	No	6	6	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	23.57
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FCZ_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?15	S:S:N2	30.62	No	No	6	1	2
H:H:?15	S:S:D282	4.84	No	No	2	1	2
H:H:?15	H:H:?16	35.24	No	No	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	35.24
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8FD0

Sensory

Opsins

Rhodopsin

Bos Taurus

3.71

2023-08-30

10.1038/s41467-023-40911-9

A 2D representation of the interactions of NAG in 8FD0
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:N2	30.62	1	Yes	No	0	6	0	1
R:R:N15	R:R:T4	5.85	1	No	No	7	6	1	2
R:R:T4	R:R:V20	11.11	1	No	Yes	6	6	2	1
R:R:V11	R:R:V20	4.81	1	Yes	Yes	8	6	2	1
R:R:V11	R:R:Y30	3.79	1	Yes	Yes	8	4	2	2
R:R:F13	R:R:V20	5.24	1	No	Yes	4	6	2	1
R:R:F13	R:R:Y30	4.13	1	No	Yes	4	4	2	2
R:R:N15	R:R:V20	11.82	1	No	Yes	7	6	1	1
H:H:?1	R:R:N15	24.5	1	Yes	No	0	7	0	1
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	7.57	1	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	3.99	1	Yes	Yes	0	6	0	1
R:R:F283	R:R:S281	5.28	3	Yes	No	4	4	2	1
H:H:?1	R:R:S281	4.02	1	Yes	No	0	4	0	1
H:H:?1	R:R:D282	6.05	1	Yes	No	0	2	0	1
H:H:?1	H:H:?2	66.08	1	Yes	No	0	0	0	1
H:H:?2	H:H:?3	65.31	1	No	Yes	0	0	1	2
H:H:?2	H:H:?6	10.16	1	No	No	0	0	1	2
H:H:?3	H:H:?6	31	1	Yes	No	0	0	2	2

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	20.19
Average Nodes In Shell	15.00
Average Hubs In Shell	6.00
Average Links In Shell	19.00
Average Links Mediated by Hubs In Shell	17.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FD0
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:N2	30.62	1	Yes	No	0	6	1	2
R:R:N15	R:R:V20	11.82	1	No	Yes	7	6	2	2
H:H:?1	R:R:N15	24.5	1	Yes	No	0	7	1	2
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	1	2
H:H:?1	R:R:V20	3.99	1	Yes	Yes	0	6	1	2
H:H:?1	R:R:S281	4.02	1	Yes	No	0	4	1	2
H:H:?1	R:R:D282	6.05	1	Yes	No	0	2	1	2
H:H:?1	H:H:?2	66.08	1	Yes	No	0	0	1	0
H:H:?2	H:H:?3	65.31	1	No	Yes	0	0	0	1
H:H:?2	H:H:?6	10.16	1	No	No	0	0	0	1
H:H:?3	H:H:?4	35.43	1	Yes	No	0	0	1	2
H:H:?3	H:H:?5	11.53	1	Yes	No	0	0	1	2
H:H:?3	H:H:?6	31	1	Yes	No	0	0	1	1
H:H:?4	H:H:?5	31.74	1	No	No	0	0	2	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	47.18
Average Nodes In Shell	12.00
Average Hubs In Shell	3.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FD0
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
H:H:?2	H:H:?3	65.31	1	No	Yes	2	1
H:H:?2	H:H:?6	10.16	1	No	No	2	2
H:H:?3	H:H:?4	35.43	1	Yes	No	1	1
H:H:?3	H:H:?5	11.53	1	Yes	No	1	0
H:H:?3	H:H:?6	31	1	Yes	No	1	2
H:H:?4	H:H:?5	31.74	1	No	No	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	21.63
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8FD0_poly

Sensory

Opsins

Rhodopsin

Bos Taurus

3.71

2023-08-30

10.1038/s41467-023-40911-9

A 2D representation of the interactions of NAG in 8FD0_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	5.85	1	No	No	7	6	1	2
R:R:T4	R:R:V20	11.11	1	No	Yes	6	6	2	1
R:R:V11	R:R:V20	4.81	1	No	Yes	8	6	2	1
R:R:V11	R:R:Y30	3.79	1	No	Yes	8	4	2	2
R:R:F13	R:R:V20	5.24	1	No	Yes	4	6	2	1
R:R:F13	R:R:Y30	4.13	1	No	Yes	4	4	2	2
R:R:N15	R:R:V20	11.82	1	No	Yes	7	6	1	1
H:H:?1	R:R:N15	24.5	1	Yes	No	0	7	0	1
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	7.57	1	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	3.99	1	Yes	Yes	0	6	0	1
H:H:?1	H:H:?2	33.04	1	Yes	No	0	0	0	1
H:H:?2	H:H:?3	33.3	1	No	Yes	0	0	1	2
H:H:?2	H:H:?6	10.16	1	No	No	0	0	1	2
H:H:?3	H:H:?6	31	1	Yes	No	0	0	2	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	16.91
Average Nodes In Shell	11.00
Average Hubs In Shell	4.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	13.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FD0_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:V20	11.82	1	No	Yes	7	6	2	2
H:H:?1	R:R:N15	24.5	1	Yes	No	0	7	1	2
H:H:?1	R:R:G18	6.1	1	Yes	No	0	3	1	2
H:H:?1	R:R:V20	3.99	1	Yes	Yes	0	6	1	2
H:H:?1	H:H:?2	33.04	1	Yes	No	0	0	1	0
H:H:?2	H:H:?3	33.3	1	No	Yes	0	0	0	1
H:H:?2	H:H:?6	10.16	1	No	No	0	0	0	1
H:H:?3	H:H:?4	35.43	1	Yes	No	0	0	1	2
H:H:?3	H:H:?5	11.53	1	Yes	No	0	0	1	2
H:H:?3	H:H:?6	31	1	Yes	No	0	0	1	1
H:H:?4	H:H:?5	31.74	1	No	No	0	0	2	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	25.50
Average Nodes In Shell	9.00
Average Hubs In Shell	3.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FD0_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
H:H:?2	H:H:?3	33.3	1	No	Yes	2	1
H:H:?2	H:H:?6	10.16	1	No	No	2	2
H:H:?3	H:H:?4	35.43	1	Yes	No	1	1
H:H:?3	H:H:?5	11.53	1	Yes	No	1	0
H:H:?3	H:H:?6	31	1	Yes	No	1	2
H:H:?4	H:H:?5	31.74	1	No	No	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	21.63
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FD0_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?7	R:R:N2	30.62	0	Yes	No	0	6	0	1
R:R:F283	R:R:S281	5.28	5	Yes	No	4	4	2	1
H:H:?7	R:R:S281	4.02	0	Yes	No	0	4	0	1
H:H:?7	R:R:D282	6.05	0	Yes	No	0	2	0	1
H:H:?7	H:H:?8	33.04	0	Yes	No	0	0	0	1
H:H:?8	H:H:?9	32.02	0	No	No	0	0	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.43
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FD0_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?7	R:R:N2	30.62	Yes	No	6	1	2
H:H:?7	R:R:S281	4.02	Yes	No	4	1	2
H:H:?7	R:R:D282	6.05	Yes	No	2	1	2
H:H:?7	H:H:?8	33.04	Yes	No	0	1	0
H:H:?8	H:H:?9	32.02	No	No	0	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	32.53
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FD0_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N15	S:S:T4	5.85	2	Yes	No	7	6	1	1
S:S:T4	S:S:V20	11.11	2	No	Yes	6	6	1	1
H:H:?10	S:S:T4	3.94	2	Yes	No	0	6	0	1
S:S:V11	S:S:V20	4.81	2	No	Yes	8	6	2	1
S:S:V11	S:S:Y30	3.79	2	No	Yes	8	4	2	2
S:S:F13	S:S:V20	5.24	0	No	Yes	4	6	2	1
S:S:N15	S:S:V20	11.82	2	Yes	Yes	7	6	1	1
H:H:?10	S:S:N15	24.5	2	Yes	Yes	0	7	0	1
H:H:?10	S:S:G18	6.1	2	Yes	No	0	3	0	1
S:S:V20	S:S:Y30	7.57	2	Yes	Yes	6	4	1	2
H:H:?10	S:S:V20	5.32	2	Yes	Yes	0	6	0	1
S:S:E25	S:S:R21	4.65	0	No	No	7	4	2	1
H:H:?10	S:S:R21	19.51	2	Yes	No	0	4	0	1
H:H:?10	H:H:?11	33.04	2	Yes	No	0	0	0	1
H:H:?11	H:H:?12	33.3	2	No	No	0	0	1	2
H:H:?11	H:H:?14	11.43	2	No	No	0	0	1	2
H:H:?12	H:H:?14	31	2	No	No	0	0	2	2
S:S:M1	S:S:N15	2.8	0	No	Yes	6	7	2	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	15.40
Average Nodes In Shell	14.00
Average Hubs In Shell	4.00
Average Links In Shell	18.00
Average Links Mediated by Hubs In Shell	14.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FD0_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N15	S:S:T4	5.85	2	Yes	No	7	6	2	2
S:S:T4	S:S:V20	11.11	2	No	Yes	6	6	2	2
H:H:?10	S:S:T4	3.94	2	Yes	No	0	6	1	2
S:S:N15	S:S:V20	11.82	2	Yes	Yes	7	6	2	2
H:H:?10	S:S:N15	24.5	2	Yes	Yes	0	7	1	2
H:H:?10	S:S:G18	6.1	2	Yes	No	0	3	1	2
H:H:?10	S:S:V20	5.32	2	Yes	Yes	0	6	1	2
H:H:?10	S:S:R21	19.51	2	Yes	No	0	4	1	2
H:H:?10	H:H:?11	33.04	2	Yes	No	0	0	1	0
H:H:?11	H:H:?12	33.3	2	No	No	0	0	0	1
H:H:?11	H:H:?14	11.43	2	No	No	0	0	0	1
H:H:?12	H:H:?13	38.38	2	No	No	0	0	1	2
H:H:?12	H:H:?14	31	2	No	No	0	0	1	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	25.92
Average Nodes In Shell	10.00
Average Hubs In Shell	3.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FD0_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?15	S:S:N2	30.62	0	Yes	No	0	6	0	1
S:S:F283	S:S:S281	5.28	6	Yes	No	4	4	2	1
H:H:?15	S:S:S281	4.02	0	Yes	No	0	4	0	1
H:H:?15	S:S:D282	6.05	0	Yes	No	0	2	0	1
H:H:?15	H:H:?16	35.24	0	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.98
Average Nodes In Shell	6.00
Average Hubs In Shell	2.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FD0_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node2Cons	Node1Shell	Node2Shell
H:H:?15	S:S:N2	30.62	Yes	No	6	1	2
H:H:?15	S:S:S281	4.02	Yes	No	4	1	2
H:H:?15	S:S:D282	6.05	Yes	No	2	1	2
H:H:?15	H:H:?16	35.24	Yes	No	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	35.24
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8FD1

Sensory

Opsins

Rhodopsin

Bos Taurus

4.25

2023-08-30

10.1038/s41467-023-40911-9

A 2D representation of the interactions of NAG in 8FD1
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	10.77	2	No	No	2	6	1	1
H:H:?1	R:R:N2	28.17	2	Yes	No	0	6	0	1
R:R:N15	R:R:T4	5.85	2	No	No	7	6	1	2
R:R:T4	R:R:V20	12.69	2	No	Yes	6	6	2	1
R:R:V11	R:R:V20	4.81	0	No	Yes	8	6	2	1
R:R:N15	R:R:V20	13.3	2	No	Yes	7	6	1	1
H:H:?1	R:R:N15	26.95	2	Yes	No	0	7	0	1
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	10.09	2	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	6.64	2	Yes	Yes	0	6	0	1
H:H:?1	R:R:D282	6.05	2	Yes	No	0	2	0	1
H:H:?1	H:H:?2	70.48	2	Yes	No	0	0	0	1
H:H:?2	H:H:?3	70.43	2	No	Yes	0	0	1	2
H:H:?2	H:H:?6	11.43	2	No	No	0	0	1	2
H:H:?3	H:H:?6	31	2	Yes	No	0	0	2	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	24.06
Average Nodes In Shell	12.00
Average Hubs In Shell	4.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FD1
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	10.77	2	No	No	2	6	2	2
H:H:?1	R:R:N2	28.17	2	Yes	No	0	6	1	2
R:R:N15	R:R:V20	13.3	2	No	Yes	7	6	2	2
H:H:?1	R:R:N15	26.95	2	Yes	No	0	7	1	2
H:H:?1	R:R:G18	6.1	2	Yes	No	0	3	1	2
H:H:?1	R:R:V20	6.64	2	Yes	Yes	0	6	1	2
H:H:?1	R:R:D282	6.05	2	Yes	No	0	2	1	2
H:H:?1	H:H:?2	70.48	2	Yes	No	0	0	1	0
H:H:?2	H:H:?3	70.43	2	No	Yes	0	0	0	1
H:H:?2	H:H:?6	11.43	2	No	No	0	0	0	1
H:H:?3	H:H:?4	36.91	2	Yes	No	0	0	1	2
H:H:?3	H:H:?5	28.17	2	Yes	No	0	0	1	2
H:H:?3	H:H:?6	31	2	Yes	No	0	0	1	1
H:H:?4	H:H:?5	29.2	2	No	No	0	0	2	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	50.78
Average Nodes In Shell	11.00
Average Hubs In Shell	3.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FD1
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
H:H:?2	H:H:?3	70.43	2	No	Yes	2	1
H:H:?2	H:H:?6	11.43	2	No	No	2	2
H:H:?3	H:H:?4	36.91	2	Yes	No	1	1
H:H:?3	H:H:?5	28.17	2	Yes	No	1	0
H:H:?3	H:H:?6	31	2	Yes	No	1	2
H:H:?4	H:H:?5	29.2	2	No	No	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	28.69
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8FD1_poly

Sensory

Opsins

Rhodopsin

Bos Taurus

4.25

2023-08-30

10.1038/s41467-023-40911-9

A 2D representation of the interactions of NAG in 8FD1_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:T4	5.85	3	No	No	7	6	1	2
R:R:T4	R:R:V20	12.69	3	No	Yes	6	6	2	1
R:R:V11	R:R:V20	4.81	0	No	Yes	8	6	2	1
R:R:N15	R:R:V20	13.3	3	No	Yes	7	6	1	1
H:H:?1	R:R:N15	26.95	3	Yes	No	0	7	0	1
H:H:?1	R:R:G18	6.1	3	Yes	No	0	3	0	1
R:R:V20	R:R:Y30	10.09	3	Yes	Yes	6	4	1	2
H:H:?1	R:R:V20	6.64	3	Yes	Yes	0	6	0	1
H:H:?1	H:H:?2	34.14	3	Yes	No	0	0	0	1
H:H:?2	H:H:?3	33.3	3	No	Yes	0	0	1	2
H:H:?2	H:H:?6	11.43	3	No	No	0	0	1	2
H:H:?3	H:H:?6	31	3	Yes	No	0	0	2	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	18.46
Average Nodes In Shell	10.00
Average Hubs In Shell	4.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FD1_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N15	R:R:V20	13.3	3	No	Yes	7	6	2	2
H:H:?1	R:R:N15	26.95	3	Yes	No	0	7	1	2
H:H:?1	R:R:G18	6.1	3	Yes	No	0	3	1	2
H:H:?1	R:R:V20	6.64	3	Yes	Yes	0	6	1	2
H:H:?1	H:H:?2	34.14	3	Yes	No	0	0	1	0
H:H:?2	H:H:?3	33.3	3	No	Yes	0	0	0	1
H:H:?2	H:H:?6	11.43	3	No	No	0	0	0	1
H:H:?3	H:H:?4	36.91	3	Yes	No	0	0	1	2
H:H:?3	H:H:?5	28.17	3	Yes	No	0	0	1	2
H:H:?3	H:H:?6	31	3	Yes	No	0	0	1	1
H:H:?4	H:H:?5	29.2	3	No	No	0	0	2	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	26.29
Average Nodes In Shell	9.00
Average Hubs In Shell	3.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FD1_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
H:H:?2	H:H:?3	33.3	3	No	Yes	2	1
H:H:?2	H:H:?6	11.43	3	No	No	2	2
H:H:?3	H:H:?4	36.91	3	Yes	No	1	1
H:H:?3	H:H:?5	28.17	3	Yes	No	1	0
H:H:?3	H:H:?6	31	3	Yes	No	1	2
H:H:?4	H:H:?5	29.2	3	No	No	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	28.69
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FD1_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	10.77	11	No	No	2	6	1	1
H:H:?7	R:R:N2	28.17	11	Yes	No	0	6	0	1
R:R:F283	R:R:S281	5.28	1	No	No	4	4	2	1
H:H:?7	R:R:D282	6.05	11	Yes	No	0	2	0	1
H:H:?7	H:H:?8	36.34	11	Yes	No	0	0	0	1
H:H:?8	H:H:?9	37.14	0	No	No	0	0	1	2
H:H:?7	R:R:S281	4.02	11	Yes	No	0	4	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.64
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FD1_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D282	R:R:N2	10.77	11	No	No	2	6	2	2
H:H:?7	R:R:N2	28.17	11	Yes	No	0	6	1	2
H:H:?7	R:R:D282	6.05	11	Yes	No	0	2	1	2
H:H:?7	H:H:?8	36.34	11	Yes	No	0	0	1	0
H:H:?8	H:H:?9	37.14	0	No	No	0	0	0	1
H:H:?7	R:R:S281	4.02	11	Yes	No	0	4	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	36.74
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FD1_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N15	S:S:T4	5.85	4	No	No	7	6	1	2
S:S:T4	S:S:V20	12.69	4	No	Yes	6	6	2	1
S:S:V11	S:S:V20	4.81	0	No	Yes	8	6	2	1
S:S:N15	S:S:V20	13.3	4	No	Yes	7	6	1	1
H:H:?10	S:S:N15	24.5	4	Yes	No	0	7	0	1
H:H:?10	S:S:G18	4.58	4	Yes	No	0	3	0	1
S:S:V20	S:S:Y30	8.83	4	Yes	Yes	6	4	1	2
H:H:?10	S:S:V20	5.32	4	Yes	Yes	0	6	0	1
H:H:?10	S:S:R21	17.34	4	Yes	No	0	4	0	1
H:H:?10	H:H:?11	33.04	4	Yes	No	0	0	0	1
H:H:?11	H:H:?12	32.02	4	No	No	0	0	1	2
H:H:?11	H:H:?14	11.43	4	No	No	0	0	1	2
H:H:?12	H:H:?14	31	4	No	No	0	0	2	2

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	16.96
Average Nodes In Shell	11.00
Average Hubs In Shell	3.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FD1_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N15	S:S:V20	13.3	4	No	Yes	7	6	2	2
H:H:?10	S:S:N15	24.5	4	Yes	No	0	7	1	2
H:H:?10	S:S:G18	4.58	4	Yes	No	0	3	1	2
H:H:?10	S:S:V20	5.32	4	Yes	Yes	0	6	1	2
H:H:?10	S:S:R21	17.34	4	Yes	No	0	4	1	2
H:H:?10	H:H:?11	33.04	4	Yes	No	0	0	1	0
H:H:?11	H:H:?12	32.02	4	No	No	0	0	0	1
H:H:?11	H:H:?14	11.43	4	No	No	0	0	0	1
H:H:?12	H:H:?13	39.86	4	No	No	0	0	1	2
H:H:?12	H:H:?14	31	4	No	No	0	0	1	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	25.50
Average Nodes In Shell	9.00
Average Hubs In Shell	2.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FD1_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:D282	S:S:N2	10.77	16	No	No	2	6	1	1
H:H:?15	S:S:N2	29.4	16	Yes	No	0	6	0	1
S:S:F283	S:S:S281	5.28	2	No	No	4	4	2	1
H:H:?15	S:S:D282	9.68	16	Yes	No	0	2	0	1
H:H:?15	H:H:?16	33.04	16	Yes	No	0	0	0	1
H:H:?15	S:S:S281	2.68	16	Yes	No	0	4	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.70
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8FD1_poly
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:D282	S:S:N2	10.77	16	No	No	2	6	2	2
H:H:?15	S:S:N2	29.4	16	Yes	No	0	6	1	2
H:H:?15	S:S:D282	9.68	16	Yes	No	0	2	1	2
H:H:?15	H:H:?16	33.04	16	Yes	No	0	0	1	0
H:H:?15	S:S:S281	2.68	16	Yes	No	0	4	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	33.04
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8I2G

Protein

Glycoprotein hormone

FSH

Homo sapiens

Glycoprotein hormones alpha chain

Compound 716340

Gs/Beta1/Gamma2

2.8

2023-03-29

10.1038/s41467-023-36170-3

A 2D representation of the interactions of NAG in 8I2G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
L:L:K44	L:L:T39	7.51	Yes	No	1	2
L:L:K44	L:L:L41	2.82	Yes	No	1	2
L:L:K44	L:L:Q50	8.14	Yes	No	1	2
H:H:?1	L:L:K44	6.29	Yes	Yes	0	1
H:H:?1	L:L:N52	30.62	Yes	No	0	1
M:M:L56	M:M:P77	4.93	No	No	2	1
M:M:P77	M:M:Y76	4.17	No	Yes	1	2
H:H:?1	M:M:P77	2.93	Yes	No	0	1
H:H:?1	H:H:?2	33.04	Yes	No	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	18.22
Average Nodes In Shell	10.00
Average Hubs In Shell	3.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8I2G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
H:H:?1	L:L:K44	6.29	Yes	Yes	1	2
H:H:?1	L:L:N52	30.62	Yes	No	1	2
H:H:?1	M:M:P77	2.93	Yes	No	1	2
H:H:?1	H:H:?2	33.04	Yes	No	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	33.04
Average Nodes In Shell	5.00
Average Hubs In Shell	2.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8I2G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N163	R:R:R162	6.03	14	Yes	No	7	4	1	2
R:R:N163	R:R:V166	5.91	14	Yes	No	7	1	1	2
R:R:N163	R:R:N191	4.09	14	Yes	Yes	7	5	1	1
H:H:?712	R:R:N163	12.25	14	No	Yes	0	7	0	1
R:R:C188	R:R:N191	4.72	14	No	Yes	4	5	2	1
R:R:C188	R:R:H215	4.42	14	No	Yes	4	2	2	2
R:R:G192	R:R:N191	5.09	14	No	Yes	5	5	1	1
R:R:H215	R:R:N191	2.55	14	Yes	Yes	2	5	2	1
R:R:G216	R:R:N191	3.39	14	No	Yes	4	5	2	1
H:H:?712	R:R:N191	26.95	14	No	Yes	0	5	0	1
H:H:?712	R:R:G192	3.05	14	No	No	0	5	0	1
R:R:G216	R:R:H215	3.18	14	No	Yes	4	2	2	2

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	14.08
Average Nodes In Shell	9.00
Average Hubs In Shell	3.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8I2G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
L:L:L12	L:L:L26	12.46	0	No	No	2	1
L:L:N15	L:L:S19	11.92	10	Yes	No	2	2
L:L:I25	L:L:N15	2.83	10	Yes	Yes	1	2
L:L:I25	L:L:S19	6.19	10	Yes	No	1	2
L:L:A23	L:L:Q20	3.03	0	No	No	1	2
H:H:?101	L:L:A23	2.81	10	Yes	No	0	1
H:H:?101	L:L:P24	10.25	10	Yes	No	0	1
L:L:I25	L:L:V76	4.61	10	Yes	No	1	2
H:H:?101	L:L:I25	3.82	10	Yes	Yes	0	1
L:L:L26	L:L:N78	2.75	10	No	No	1	1
H:H:?101	L:L:L26	2.47	10	Yes	No	0	1
L:L:N78	L:L:T80	4.39	10	No	No	1	2
H:H:?101	L:L:N78	25.72	10	Yes	No	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	9.01
Average Nodes In Shell	12.00
Average Hubs In Shell	3.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8I2G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
M:M:N24	M:M:N7	2.72	21	Yes	No	1	1
H:H:?201	M:M:N7	30.62	21	No	No	0	1
M:M:N24	M:M:T9	2.92	21	Yes	No	1	2
H:H:?202	M:M:T9	13.15	21	No	No	2	2
H:H:?201	M:M:N24	3.67	21	No	Yes	0	1
H:H:?202	M:M:N24	13.47	21	No	Yes	2	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	17.14
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8I2G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
M:M:N24	M:M:N7	2.72	21	Yes	No	1	2
H:H:?201	M:M:N7	30.62	21	No	No	2	2
M:M:N24	M:M:T9	2.92	21	Yes	No	1	1
H:H:?202	M:M:T9	13.15	21	No	No	0	1
H:H:?201	M:M:N24	3.67	21	No	Yes	2	1
H:H:?202	M:M:N24	13.47	21	No	Yes	0	1
M:M:S22	M:M:T9	1.6	0	No	No	2	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	13.31
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8IHB

Alicarboxylic acid

Hydroxycarboxylic acid

HCA2

Homo Sapiens

GSK256073

Gi1/Beta1/Gamma2

2.85

2023-09-13

10.1038/s41467-023-41650-7

A 2D representation of the interactions of NAG in 8IHB
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F10	R:R:N17	7.25	No	No	7	5	2	1
H:H:?601	R:R:N17	30.62	No	No	0	5	0	1
R:R:E12	R:R:N17	1.31	No	No	5	5	2	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	30.62
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8IHF

Alicarboxylic acid

Hydroxycarboxylic acid

HCA2

Homo Sapiens

MK6892

Gi1/Beta1/Gamma2

2.97

2023-08-30

10.1038/s41467-023-41650-7

A 2D representation of the interactions of NAG in 8IHF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F10	R:R:N17	8.46	No	Yes	7	5	2	1
H:H:?1	R:R:N17	25.72	No	Yes	0	5	0	1
H:H:?1	R:R:Q264	10.69	No	No	0	3	0	1
R:R:N17	R:R:T263	1.46	Yes	No	5	3	1	2
R:R:E12	R:R:N17	1.31	No	Yes	5	5	2	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	18.20
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8IHH

Alicarboxylic acid

Hydroxycarboxylic acid

HCA2

Homo Sapiens

LUF6283

Gi1/Beta1/Gamma2

3.06

2023-08-30

10.1038/s41467-023-41650-7

A 2D representation of the interactions of NAG in 8IHH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F10	R:R:N17	10.87	No	No	7	5	2	1
R:R:N17	R:R:T263	7.31	No	No	5	3	1	2
H:H:?1	R:R:N17	34.3	No	No	0	5	0	1
H:H:?1	R:R:Q264	7.12	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	20.71
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8IHI

Alicarboxylic acid

Hydroxycarboxylic acid

HCA2

Homo Sapiens

Acifran

Gi1/Beta1/Gamma2

3.11

2023-08-30

10.1038/s41467-023-41650-7

A 2D representation of the interactions of NAG in 8IHI
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E12	R:R:F10	4.66	28	No	Yes	5	7	2	2
R:R:F10	R:R:N17	9.67	28	Yes	Yes	7	5	2	1
R:R:E12	R:R:N17	3.94	28	No	Yes	5	5	2	1
R:R:N17	R:R:T263	4.39	28	Yes	No	5	3	1	2
H:H:?1	R:R:N17	29.4	0	No	Yes	0	5	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	29.40
Average Nodes In Shell	5.00
Average Hubs In Shell	2.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8IKJ

Adhesion

ADGRE5

Homo Sapiens

3.2

2024-02-14

10.1016/j.molcel.2023.12.020

A 2D representation of the interactions of NAG in 8IKJ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:N413	36.74	0	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	36.74
Average Nodes In Shell	2.00
Average Hubs In Shell	0.00
Average Links In Shell	1.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8IKJ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:M309	R:R:T409	1.51	1	Yes	Yes	8	4	2	1
R:R:A311	R:R:P312	1.87	0	No	Yes	4	6	2	1
R:R:E316	R:R:P312	6.29	1	No	Yes	4	6	2	1
R:R:P312	R:R:T409	3.5	1	Yes	Yes	6	4	1	1
H:H:?2	R:R:P312	2.93	1	Yes	Yes	0	6	0	1
R:R:E316	R:R:T409	2.82	1	No	Yes	4	4	2	1
R:R:N406	R:R:T408	5.85	1	No	No	5	4	1	2
R:R:N406	R:R:T409	5.85	1	No	Yes	5	4	1	1
H:H:?2	R:R:N406	30.62	1	Yes	No	0	5	0	1
H:H:?2	R:R:T409	3.94	1	Yes	Yes	0	4	0	1
R:R:L469	R:R:S471	1.5	0	No	No	3	4	2	1
H:H:?2	R:R:S471	2.68	1	Yes	No	0	4	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	10.04
Average Nodes In Shell	10.00
Average Hubs In Shell	4.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8IKJ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:P480	R:R:P481	1.95	No	No	7	4	2	1
H:H:?3	R:R:P481	1.46	No	No	0	4	0	1
H:H:?3	R:R:K519	2.52	No	No	0	4	0	1
H:H:?3	R:R:N520	29.4	No	No	0	6	0	1
R:R:D484	R:R:K519	1.38	No	No	2	4	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	11.13
Average Nodes In Shell	6.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8J6P

Alicarboxylic acid

Hydroxycarboxylic acid

HCA2

Homo Sapiens

Niacin

Compound 9n

Gi1/Beta1/Gamma2

2.55

2023-12-06

10.1038/s41467-023-43537-z

A 2D representation of the interactions of NAG in 8J6P
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F10	R:R:N17	8.46	No	No	7	5	2	1
H:H:?405	R:R:N17	30.62	No	No	0	5	0	1
R:R:N17	R:R:T263	1.46	No	No	5	3	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	30.62
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8J6Q

Alicarboxylic acid

Hydroxycarboxylic acid

HCA2

Homo Sapiens

Beta-hydroxybutyrate

Compound 9n

Gi1/Beta1/Gamma2

2.6

2023-12-06

10.1038/s41467-023-43537-z

A 2D representation of the interactions of NAG in 8J6Q
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F10	R:R:N17	8.46	No	No	7	5	2	1
H:H:?405	R:R:N17	30.62	No	No	0	5	0	1
R:R:N17	R:R:T263	1.46	No	No	5	3	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	30.62
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8J6R

Alicarboxylic acid

Hydroxycarboxylic acid

HCA2

Homo Sapiens

MK6892

Gi1/Beta1/Gamma2

2.76

2023-12-06

10.1038/s41467-023-43537-z

A 2D representation of the interactions of NAG in 8J6R
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F10	R:R:N17	7.25	No	No	7	5	2	1
H:H:?402	R:R:K15	2.52	No	No	0	3	0	1
R:R:N17	R:R:T263	4.39	No	No	5	3	1	2
H:H:?402	R:R:N17	24.5	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.51
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8JCU

Aminoacid

Metabotropic glutamate

mGlu2; mGlu3

Homo sapiens

LY341495

2.8

2023-06-21

10.1038/s41422-023-00830-2

A 2D representation of the interactions of NAG in 8JCU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1102	R:R:N203	25.72	0	No	No	0	4	0	1
R:R:N203	R:R:R200	1.21	0	No	Yes	4	4	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	25.72
Average Nodes In Shell	3.00
Average Hubs In Shell	1.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8JCU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N209	S:S:R206	4.82	No	Yes	4	5	1	2
H:H:?2001	S:S:N209	26.95	No	No	0	4	0	1
S:S:P505	S:S:S503	3.56	No	No	7	4	2	1
H:H:?2001	S:S:S503	2.68	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.81
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8JCV

Aminoacid

Metabotropic glutamate

mGlu2; mGlu3

Homo sapiens

LY341495

3.4

2023-06-21

10.1038/s41422-023-00830-2

A 2D representation of the interactions of NAG in 8JCV
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F201	R:R:F202	4.29	No	No	5	8	2	1
R:R:F202	R:R:W204	18.04	No	No	8	9	1	2
H:H:?2001	R:R:N203	25.72	No	No	0	4	0	1
H:H:?2001	R:R:F202	1.09	No	No	0	8	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.40
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8JCV
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N209	S:S:R206	6.03	0	No	No	4	5	1	2
H:H:?2002	S:S:N209	26.95	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	26.95
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8JCW

Aminoacid

Metabotropic glutamate

mGlu2; mGlu3

Homo sapiens

LY341495

2023-06-21

10.1038/s41422-023-00830-2

A 2D representation of the interactions of NAG in 8JCW
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N203	R:R:R200	6.03	0	No	No	4	4	1	2
H:H:?1101	R:R:N203	26.95	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	26.95
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8JCW
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1002	S:S:N209	26.95	0	No	No	0	4	0	1
S:S:N209	S:S:R206	1.21	0	No	No	4	5	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	26.95
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8JCX

Aminoacid

Metabotropic glutamate

mGlu2; mGlu3

Homo sapiens

LY341495

2023-06-21

10.1038/s41422-023-00830-2

A 2D representation of the interactions of NAG in 8JCX
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1101	R:R:N203	26.95	0	No	No	0	4	0	1
R:R:N203	R:R:R200	1.21	0	No	No	4	4	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	26.95
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8JCX
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1002	S:S:N209	28.17	0	No	No	0	4	0	1
S:S:N209	S:S:R206	1.21	0	No	Yes	4	5	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	28.17
Average Nodes In Shell	3.00
Average Hubs In Shell	1.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8JCY

Aminoacid

Metabotropic glutamate

mGlu2; mGlu3

Homo sapiens

LY341495

2.9

2023-06-21

10.1038/s41422-023-00830-2

A 2D representation of the interactions of NAG in 8JCY
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F201	R:R:F202	9.65	1	Yes	Yes	5	8	2	1
R:R:F202	R:R:W204	12.03	1	Yes	Yes	8	9	1	2
R:R:F202	R:R:W487	11.02	1	Yes	Yes	8	7	1	2
H:H:?2001	R:R:N203	26.95	0	No	No	0	4	0	1
R:R:W204	R:R:W487	5.62	1	Yes	Yes	9	7	2	2
H:H:?2001	R:R:F202	1.09	0	No	Yes	0	8	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	14.02
Average Nodes In Shell	6.00
Average Hubs In Shell	4.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8JCY
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N209	S:S:R206	3.62	No	No	4	5	1	2
S:S:F207	S:S:F208	11.79	No	Yes	4	8	2	1
S:S:F208	S:S:W210	16.04	Yes	Yes	8	9	1	2
S:S:F208	S:S:V494	3.93	Yes	No	8	3	1	2
S:S:F208	S:S:S503	3.96	Yes	No	8	4	1	2
H:H:?2002	S:S:F208	4.35	No	Yes	0	8	0	1
H:H:?2002	S:S:N209	29.4	No	No	0	4	0	1
S:S:F208	S:S:I204	2.51	Yes	No	8	7	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	16.88
Average Nodes In Shell	9.00
Average Hubs In Shell	2.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8JCZ

Aminoacid

Metabotropic glutamate

mGlu2; mGlu3

Homo sapiens

LY341495

2023-06-21

10.1038/s41422-023-00830-2

A 2D representation of the interactions of NAG in 8JCZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F201	R:R:F202	8.57	1	No	Yes	5	8	2	1
R:R:F201	R:R:L480	4.87	1	No	Yes	5	6	2	2
R:R:F202	R:R:W204	13.03	1	Yes	Yes	8	9	1	2
R:R:F202	R:R:L480	3.65	1	Yes	Yes	8	6	1	2
R:R:F202	R:R:W487	13.03	1	Yes	Yes	8	7	1	2
H:H:?2001	R:R:N203	28.17	0	No	No	0	4	0	1
R:R:W204	R:R:W487	7.5	1	Yes	Yes	9	7	2	2
H:H:?2001	R:R:F202	1.09	0	No	Yes	0	8	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	14.63
Average Nodes In Shell	7.00
Average Hubs In Shell	4.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8JCZ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N209	S:S:R206	6.03	0	No	No	4	5	1	2
H:H:?2002	S:S:N209	26.95	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	26.95
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8JD0

Aminoacid

Metabotropic glutamate

mGlu2; mGlu3

Homo sapiens

Glutamate

J9R

3.3

2023-06-21

10.1038/s41422-023-00830-2

A 2D representation of the interactions of NAG in 8JD0
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1101	R:R:N203	26.95	0	No	No	0	4	0	1
R:R:N203	R:R:R200	1.21	0	No	No	4	4	1	2

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	26.95
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8JD0
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N209	S:S:R206	6.03	0	No	No	4	5	1	2
H:H:?1002	S:S:N209	26.95	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	26.95
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8JD2

Aminoacid

Metabotropic glutamate

mGlu2; mGlu3

Homo sapiens

Glutamate

2.8

2023-06-21

10.1038/s41422-023-00830-2

A 2D representation of the interactions of NAG in 8JD2
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N203	R:R:R200	3.62	0	No	Yes	4	4	1	2
H:H:?1102	R:R:N203	30.62	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	30.62
Average Nodes In Shell	3.00
Average Hubs In Shell	1.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8JD2
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N209	S:S:R206	4.82	0	No	No	4	5	1	2
S:S:F207	S:S:F208	5.36	1	Yes	Yes	4	8	1	2
S:S:F207	S:S:L490	3.65	1	Yes	Yes	4	6	1	2
S:S:F207	S:S:L492	8.53	1	Yes	No	4	6	1	2
S:S:F208	S:S:L492	3.65	1	Yes	No	8	6	2	2
H:H:?1002	S:S:N209	28.17	0	No	No	0	4	0	1
S:S:L490	S:S:L492	6.92	1	Yes	No	6	6	2	2
H:H:?1002	S:S:F207	2.17	0	No	Yes	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	15.17
Average Nodes In Shell	7.00
Average Hubs In Shell	3.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8JD4

Aminoacid

Metabotropic glutamate

mGlu2; mGlu4

Homo sapiens

Glutamate

2.9

2023-06-21

10.1038/s41422-023-00830-2

A 2D representation of the interactions of NAG in 8JD4
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?2001	R:R:N203	26.95	No	No	0	4	0	1
R:R:L495	R:R:P496	1.64	No	No	4	8	1	2
H:H:?2001	R:R:L495	1.23	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.09
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8JD4
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D335	R:R:P336	3.22	1	No	Yes	4	6	1	2
R:R:D335	R:R:N338	8.08	1	No	No	4	4	1	1
H:H:?2002	R:R:D335	8.47	1	No	No	0	4	0	1
R:R:P336	R:R:W337	12.16	1	Yes	No	6	3	2	1
H:H:?2002	R:R:W337	6.1	1	No	No	0	3	0	1
H:H:?2002	R:R:N338	31.85	1	No	No	0	4	0	1
R:R:A363	R:R:W337	2.59	0	No	No	5	3	2	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.47
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	2.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8JD4
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N454	S:S:T464	5.85	46	No	No	5	3	1	1
H:H:?1102	S:S:N454	28.17	46	No	No	0	5	0	1
H:H:?1102	S:S:T464	9.2	46	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.69
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8JD5

Aminoacid

Metabotropic glutamate

mGlu2; mGlu4

Homo sapiens

Glutamate

BQI; HZE; PEF

Gi1/Beta1/Gamma2

3.6

2023-06-21

10.1038/s41422-023-00830-2

A 2D representation of the interactions of NAG in 8JD5
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N454	S:S:T464	2.92	48	No	No	5	3	1	1
H:H:?1	S:S:N454	25.72	48	No	No	0	5	0	1
H:H:?1	S:S:T464	11.83	48	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.77
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8SZF

Ion

Calcium-sensing

CaS

Homo sapiens

Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW

2.8

2024-02-07

10.1038/s41586-024-07055-2

A 2D representation of the interactions of NAG in 8SZF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:R205	10.84	3	Yes	No	0	4	0	1
H:H:?2	R:R:R205	5.42	3	No	No	0	4	1	1
R:R:N207	R:R:N541	17.71	3	No	No	6	5	1	1
R:R:C561	R:R:N207	6.3	3	No	No	9	6	2	1
H:H:?1	R:R:N207	12.25	3	Yes	No	0	6	0	1
R:R:F539	R:R:N541	6.04	3	No	No	1	5	1	1
R:R:F539	R:R:R544	18.17	3	No	No	1	5	1	2
H:H:?1	R:R:F539	5.43	3	Yes	No	0	1	0	1
H:H:?1	R:R:N541	28.17	3	Yes	No	0	5	0	1
H:H:?1	H:H:?2	33.04	3	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	17.95
Average Nodes In Shell	8.00
Average Hubs In Shell	1.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:R205	10.84	3	Yes	No	0	4	1	1
H:H:?2	R:R:R205	5.42	3	No	No	0	4	0	1
R:R:N207	R:R:N541	17.71	3	No	No	6	5	2	2
H:H:?1	R:R:N207	12.25	3	Yes	No	0	6	1	2
R:R:F539	R:R:N541	6.04	3	No	No	1	5	2	2
H:H:?1	R:R:F539	5.43	3	Yes	No	0	1	1	2
H:H:?1	R:R:N541	28.17	3	Yes	No	0	5	1	2
H:H:?1	H:H:?2	33.04	3	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	19.23
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:K323	6.29	17	Yes	No	0	5	0	1
R:R:V486	R:R:Y514	3.79	0	No	Yes	3	4	2	1
R:R:N488	R:R:N512	5.45	17	No	Yes	4	4	1	1
R:R:N488	R:R:Y514	4.65	17	No	Yes	4	4	1	1
H:H:?3	R:R:N488	24.5	17	Yes	No	0	4	0	1
R:R:F522	R:R:Y510	15.47	0	No	No	1	3	2	1
H:H:?3	R:R:Y510	9.41	17	Yes	No	0	3	0	1
H:H:?4	R:R:Y510	3.14	17	No	No	0	3	1	1
R:R:N512	R:R:Y514	5.81	17	Yes	Yes	4	4	1	1
R:R:A515	R:R:N512	4.69	0	No	Yes	4	4	2	1
H:H:?3	R:R:N512	14.7	17	Yes	Yes	0	4	0	1
R:R:V513	R:R:Y514	7.57	0	Yes	Yes	3	4	2	1
H:H:?3	R:R:Y514	13.59	17	Yes	Yes	0	4	0	1
H:H:?3	H:H:?4	40.75	17	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	18.21
Average Nodes In Shell	11.00
Average Hubs In Shell	4.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:K323	6.29	17	Yes	No	0	5	1	2
R:R:N488	R:R:N512	5.45	17	No	Yes	4	4	2	2
R:R:N488	R:R:Y514	4.65	17	No	Yes	4	4	2	2
H:H:?3	R:R:N488	24.5	17	Yes	No	0	4	1	2
R:R:F522	R:R:Y510	15.47	0	No	No	1	3	2	1
H:H:?3	R:R:Y510	9.41	17	Yes	No	0	3	1	1
H:H:?4	R:R:Y510	3.14	17	No	No	0	3	0	1
R:R:N512	R:R:Y514	5.81	17	Yes	Yes	4	4	2	2
H:H:?3	R:R:N512	14.7	17	Yes	Yes	0	4	1	2
H:H:?3	R:R:Y514	13.59	17	Yes	Yes	0	4	1	2
H:H:?3	H:H:?4	40.75	17	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	21.95
Average Nodes In Shell	8.00
Average Hubs In Shell	3.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?5	S:S:R205	6.5	4	Yes	No	0	4	0	1
S:S:N207	S:S:N541	17.71	4	No	No	6	5	1	1
S:S:C561	S:S:N207	3.15	4	No	No	9	6	2	1
H:H:?5	S:S:N207	14.7	4	Yes	No	0	6	0	1
S:S:F539	S:S:N541	6.04	4	No	No	1	5	1	1
S:S:F539	S:S:R544	25.66	4	No	No	1	5	1	2
H:H:?5	S:S:F539	5.43	4	Yes	No	0	1	0	1
H:H:?5	S:S:N541	29.4	4	Yes	No	0	5	0	1
S:S:D545	S:S:D578	15.97	0	No	No	5	7	1	2
H:H:?5	S:S:D545	7.26	4	Yes	No	0	5	0	1
H:H:?5	H:H:?6	37.44	4	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	16.79
Average Nodes In Shell	10.00
Average Hubs In Shell	1.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?5	S:S:R205	6.5	4	Yes	No	0	4	1	2
S:S:N207	S:S:N541	17.71	4	No	No	6	5	2	2
H:H:?5	S:S:N207	14.7	4	Yes	No	0	6	1	2
S:S:F539	S:S:N541	6.04	4	No	No	1	5	2	2
H:H:?5	S:S:F539	5.43	4	Yes	No	0	1	1	2
H:H:?5	S:S:N541	29.4	4	Yes	No	0	5	1	2
H:H:?5	S:S:D545	7.26	4	Yes	No	0	5	1	2
H:H:?5	H:H:?6	37.44	4	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	37.44
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E241	R:R:H254	3.69	3	No	No	5	3	2	1
R:R:E241	R:R:V258	9.98	3	No	No	5	4	2	2
R:R:H254	R:R:V258	5.54	3	No	No	3	4	1	2
H:H:?7	R:R:E257	4.73	3	Yes	No	0	3	0	1
H:H:?7	R:R:N261	24.5	3	Yes	No	0	4	0	1
R:R:N468	R:R:Q476	6.6	3	No	No	6	3	1	1
R:R:N468	R:R:T478	2.92	3	No	No	6	3	1	1
H:H:?7	R:R:N468	23.27	3	Yes	No	0	6	0	1
R:R:Q476	R:R:T470	5.67	3	No	No	3	5	1	2
H:H:?7	R:R:Q476	10.69	3	Yes	No	0	3	0	1
H:H:?7	R:R:T478	2.63	3	Yes	No	0	3	0	1
H:H:?7	R:R:H254	2.29	3	Yes	No	0	3	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	11.35
Average Nodes In Shell	10.00
Average Hubs In Shell	1.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:E475	S:S:K323	4.05	0	No	No	5	5	2	1
H:H:?8	S:S:K323	5.03	15	Yes	No	0	5	0	1
S:S:N468	S:S:Q476	6.6	15	No	No	6	3	1	1
S:S:N468	S:S:T478	5.85	15	No	No	6	3	1	1
H:H:?8	S:S:N468	24.5	15	Yes	No	0	6	0	1
S:S:Q476	S:S:T470	9.92	15	No	No	3	5	1	2
H:H:?8	S:S:Q476	14.25	15	Yes	No	0	3	0	1
H:H:?8	S:S:T478	2.63	15	Yes	No	0	3	0	1
S:S:V486	S:S:V513	3.21	15	No	No	3	3	2	2
S:S:V486	S:S:Y514	3.79	15	No	Yes	3	4	2	1
S:S:N488	S:S:N512	5.45	15	Yes	Yes	4	4	1	1
S:S:N488	S:S:V513	4.43	15	Yes	No	4	3	1	2
S:S:N488	S:S:Y514	3.49	15	Yes	Yes	4	4	1	1
H:H:?8	S:S:N488	24.5	15	Yes	Yes	0	4	0	1
S:S:F522	S:S:Y510	13.41	0	No	No	1	3	2	1
H:H:?8	S:S:Y510	7.32	15	Yes	No	0	3	0	1
S:S:N512	S:S:Y514	3.49	15	Yes	Yes	4	4	1	1
S:S:A515	S:S:N512	4.69	0	No	Yes	4	4	2	1
H:H:?8	S:S:N512	15.92	15	Yes	Yes	0	4	0	1
S:S:V513	S:S:Y514	5.05	15	No	Yes	3	4	2	1
H:H:?8	S:S:Y514	10.46	15	Yes	Yes	0	4	0	1

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	13.08
Average Nodes In Shell	15.00
Average Hubs In Shell	4.00
Average Links In Shell	21.00
Average Links Mediated by Hubs In Shell	15.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:F239	S:S:V258	3.93	4	Yes	Yes	6	4	2	1
K:K:?5	S:S:F239	5.83	4	Yes	Yes	0	6	2	2
S:S:E241	S:S:V258	9.98	4	No	Yes	5	4	2	1
K:K:?5	S:S:E241	2.54	4	Yes	No	0	5	2	2
S:S:H254	S:S:V258	4.15	0	No	Yes	3	4	2	1
H:H:?9	S:S:E257	4.73	0	No	No	0	3	0	1
H:H:?9	S:S:V258	3.99	0	No	Yes	0	4	0	1
K:K:?5	S:S:V258	2.85	4	Yes	Yes	0	4	2	1
H:H:?9	S:S:N261	28.17	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	12.30
Average Nodes In Shell	8.00
Average Hubs In Shell	3.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8SZG

Ion

Calcium-sensing

CaS

Homo sapiens

Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW

chim(NtGi1-Gq)/Beta1/Gamma2

3.6

2024-02-07

10.1038/s41586-024-07055-2

A 2D representation of the interactions of NAG in 8SZG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:K323	2.52	5	Yes	No	0	5	0	1
R:R:N488	R:R:N512	6.81	5	No	Yes	4	4	1	1
R:R:N488	R:R:Y514	3.49	5	No	Yes	4	4	1	1
H:H:?1	R:R:N488	25.72	5	Yes	No	0	4	0	1
R:R:F522	R:R:Y510	13.41	0	No	No	1	3	2	1
H:H:?1	R:R:Y510	11.5	5	Yes	No	0	3	0	1
H:H:?2	R:R:Y510	2.09	5	No	No	0	3	1	1
R:R:N512	R:R:Y514	5.81	5	Yes	Yes	4	4	1	1
R:R:A515	R:R:N512	4.69	0	No	Yes	4	4	2	1
H:H:?1	R:R:N512	15.92	5	Yes	Yes	0	4	0	1
H:H:?2	R:R:N512	2.45	5	No	Yes	0	4	1	1
R:R:V513	R:R:Y514	3.79	5	Yes	Yes	3	4	2	1
H:H:?1	R:R:Y514	15.69	5	Yes	Yes	0	4	0	1
H:H:?1	H:H:?2	34.14	5	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	17.58
Average Nodes In Shell	10.00
Average Hubs In Shell	4.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:K323	2.52	5	Yes	No	0	5	1	2
R:R:N488	R:R:N512	6.81	5	No	Yes	4	4	2	1
R:R:N488	R:R:Y514	3.49	5	No	Yes	4	4	2	2
H:H:?1	R:R:N488	25.72	5	Yes	No	0	4	1	2
R:R:F522	R:R:Y510	13.41	0	No	No	1	3	2	1
H:H:?1	R:R:Y510	11.5	5	Yes	No	0	3	1	1
H:H:?2	R:R:Y510	2.09	5	No	No	0	3	0	1
R:R:N512	R:R:Y514	5.81	5	Yes	Yes	4	4	1	2
R:R:A515	R:R:N512	4.69	0	No	Yes	4	4	2	1
H:H:?1	R:R:N512	15.92	5	Yes	Yes	0	4	1	1
H:H:?2	R:R:N512	2.45	5	No	Yes	0	4	0	1
H:H:?1	R:R:Y514	15.69	5	Yes	Yes	0	4	1	2
H:H:?1	H:H:?2	34.14	5	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	12.89
Average Nodes In Shell	9.00
Average Hubs In Shell	3.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R205	3.25	30	Yes	No	0	4	0	1
H:H:?4	R:R:R205	9.75	30	No	No	0	4	1	1
R:R:N207	R:R:N541	9.54	30	No	No	6	5	1	1
R:R:C561	R:R:N207	6.3	0	No	No	9	6	2	1
H:H:?3	R:R:N207	11.02	30	Yes	No	0	6	0	1
R:R:F539	R:R:N541	6.04	30	No	No	1	5	1	1
R:R:F539	R:R:R544	18.17	30	No	No	1	5	1	2
H:H:?3	R:R:F539	5.43	30	Yes	No	0	1	0	1
H:H:?3	R:R:N541	29.4	30	Yes	No	0	5	0	1
R:R:D545	R:R:D578	9.31	0	No	Yes	5	7	1	2
H:H:?3	R:R:D545	10.9	30	Yes	No	0	5	0	1
H:H:?3	H:H:?4	34.14	30	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.69
Average Nodes In Shell	10.00
Average Hubs In Shell	2.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R205	3.25	30	Yes	No	0	4	1	1
H:H:?4	R:R:R205	9.75	30	No	No	0	4	0	1
R:R:N207	R:R:N541	9.54	30	No	No	6	5	2	2
H:H:?3	R:R:N207	11.02	30	Yes	No	0	6	1	2
R:R:F539	R:R:N541	6.04	30	No	No	1	5	2	2
H:H:?3	R:R:F539	5.43	30	Yes	No	0	1	1	2
H:H:?3	R:R:N541	29.4	30	Yes	No	0	5	1	2
H:H:?3	R:R:D545	10.9	30	Yes	No	0	5	1	2
H:H:?3	H:H:?4	34.14	30	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	21.95
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?5	S:S:R205	8.67	33	Yes	No	0	4	0	1
H:H:?6	S:S:R205	2.17	33	No	No	0	4	1	1
S:S:N207	S:S:N541	10.9	33	No	No	6	5	1	1
S:S:C561	S:S:N207	6.3	0	No	No	9	6	2	1
H:H:?5	S:S:N207	7.35	33	Yes	No	0	6	0	1
S:S:F539	S:S:N541	6.04	33	No	No	1	5	1	1
S:S:F539	S:S:R544	17.1	33	No	No	1	5	1	2
H:H:?5	S:S:F539	4.35	33	Yes	No	0	1	0	1
H:H:?5	S:S:N541	24.5	33	Yes	No	0	5	0	1
H:H:?5	H:H:?6	34.14	33	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.80
Average Nodes In Shell	8.00
Average Hubs In Shell	1.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?5	S:S:R205	8.67	33	Yes	No	0	4	1	1
H:H:?6	S:S:R205	2.17	33	No	No	0	4	0	1
S:S:N207	S:S:N541	10.9	33	No	No	6	5	2	2
H:H:?5	S:S:N207	7.35	33	Yes	No	0	6	1	2
S:S:F539	S:S:N541	6.04	33	No	No	1	5	2	2
H:H:?5	S:S:F539	4.35	33	Yes	No	0	1	1	2
H:H:?5	S:S:N541	24.5	33	Yes	No	0	5	1	2
H:H:?5	H:H:?6	34.14	33	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	18.16
Average Nodes In Shell	6.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H312	R:R:N287	2.55	No	No	3	6	2	1
H:H:?7	R:R:N287	26.95	No	No	0	6	0	1
R:R:G290	R:R:T289	1.82	No	No	4	5	2	1
H:H:?7	R:R:T289	2.63	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	14.79
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N468	R:R:Q476	6.6	43	No	No	6	3	1	1
R:R:N468	R:R:T478	5.85	43	No	No	6	3	1	1
H:H:?8	R:R:N468	23.27	43	No	No	0	6	0	1
R:R:Q476	R:R:T470	7.09	43	No	No	3	5	1	2
H:H:?8	R:R:Q476	4.75	43	No	No	0	3	0	1
H:H:?8	R:R:T478	6.57	43	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	11.53
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N468	S:S:Q476	5.28	47	No	No	6	3	1	1
S:S:N468	S:S:T478	4.39	47	No	No	6	3	1	1
H:H:?9	S:S:N468	30.62	47	No	No	0	6	0	1
S:S:Q476	S:S:T470	8.5	47	No	No	3	5	1	2
H:H:?9	S:S:Q476	8.31	47	No	No	0	3	0	1
H:H:?9	S:S:T478	2.63	47	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.85
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?10	S:S:K323	5.03	38	Yes	No	0	5	0	1
S:S:V486	S:S:Y514	3.79	0	No	Yes	3	4	2	1
S:S:N488	S:S:N512	6.81	38	Yes	Yes	4	4	1	1
S:S:N488	S:S:V513	4.43	38	Yes	Yes	4	3	1	2
S:S:N488	S:S:Y514	2.33	38	Yes	Yes	4	4	1	1
H:H:?10	S:S:N488	30.62	38	Yes	Yes	0	4	0	1
S:S:N512	S:S:Y510	2.33	38	Yes	No	4	3	1	2
S:S:N512	S:S:Y514	4.65	38	Yes	Yes	4	4	1	1
H:H:?10	S:S:N512	15.92	38	Yes	Yes	0	4	0	1
S:S:V513	S:S:Y514	3.79	38	Yes	Yes	3	4	2	1
H:H:?10	S:S:Y514	15.69	38	Yes	Yes	0	4	0	1
S:S:A515	S:S:N512	1.56	0	No	Yes	4	4	2	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	16.82
Average Nodes In Shell	9.00
Average Hubs In Shell	5.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8SZH

Ion

Calcium-sensing

CaS

Homo sapiens

Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW

Gi1/Beta1/Gamma2

3.1

2024-02-07

10.1038/s41586-024-07055-2

A 2D representation of the interactions of NAG in 8SZH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E475	R:R:K323	4.05	1	Yes	No	5	5	1	1
H:H:?1	R:R:K323	3.77	1	Yes	No	0	5	0	1
R:R:M473	R:R:N471	2.8	1	Yes	Yes	4	6	2	2
R:R:E475	R:R:N471	5.26	1	Yes	Yes	5	6	1	2
R:R:E475	R:R:M473	2.71	1	Yes	Yes	5	4	1	2
H:H:?1	R:R:E475	3.55	1	Yes	Yes	0	5	0	1
R:R:V486	R:R:Y514	7.57	0	No	Yes	3	4	2	1
R:R:N488	R:R:N512	5.45	1	No	Yes	4	4	1	1
R:R:N488	R:R:Y514	2.33	1	No	Yes	4	4	1	1
H:H:?1	R:R:N488	23.27	1	Yes	No	0	4	0	1
R:R:F522	R:R:Y510	15.47	0	No	No	1	3	2	1
H:H:?1	R:R:Y510	9.41	1	Yes	No	0	3	0	1
R:R:N512	R:R:Y514	3.49	1	Yes	Yes	4	4	1	1
R:R:A515	R:R:N512	4.69	0	No	Yes	4	4	2	1
H:H:?1	R:R:N512	15.92	1	Yes	Yes	0	4	0	1
R:R:V513	R:R:Y514	5.05	0	No	Yes	3	4	2	1
H:H:?1	R:R:Y514	7.32	1	Yes	Yes	0	4	0	1
H:H:?1	H:H:?2	37.44	1	Yes	No	0	0	0	1
R:R:G487	R:R:Y514	1.45	0	No	Yes	6	4	2	1

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	14.38
Average Nodes In Shell	15.00
Average Hubs In Shell	6.00
Average Links In Shell	19.00
Average Links Mediated by Hubs In Shell	18.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E475	R:R:K323	4.05	1	Yes	No	5	5	2	2
H:H:?1	R:R:K323	3.77	1	Yes	No	0	5	1	2
H:H:?1	R:R:E475	3.55	1	Yes	Yes	0	5	1	2
R:R:N488	R:R:N512	5.45	1	No	Yes	4	4	2	2
R:R:N488	R:R:Y514	2.33	1	No	Yes	4	4	2	2
H:H:?1	R:R:N488	23.27	1	Yes	No	0	4	1	2
H:H:?1	R:R:Y510	9.41	1	Yes	No	0	3	1	2
R:R:N512	R:R:Y514	3.49	1	Yes	Yes	4	4	2	2
H:H:?1	R:R:N512	15.92	1	Yes	Yes	0	4	1	2
H:H:?1	R:R:Y514	7.32	1	Yes	Yes	0	4	1	2
H:H:?1	H:H:?2	37.44	1	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	37.44
Average Nodes In Shell	8.00
Average Hubs In Shell	4.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R205	10.84	1	Yes	No	0	4	0	1
H:H:?4	R:R:R205	27.09	1	No	No	0	4	1	1
R:R:N207	R:R:N541	16.35	1	No	No	6	5	1	1
R:R:C561	R:R:N207	7.87	1	Yes	No	9	6	2	1
H:H:?3	R:R:N207	11.02	1	Yes	No	0	6	0	1
R:R:F539	R:R:N541	7.25	1	No	No	1	5	1	1
R:R:F539	R:R:R544	23.52	1	No	No	1	5	1	2
H:H:?3	R:R:F539	5.43	1	Yes	No	0	1	0	1
H:H:?3	R:R:N541	30.62	1	Yes	No	0	5	0	1
R:R:D545	R:R:D578	11.98	0	No	Yes	5	7	1	2
H:H:?3	R:R:D545	13.32	1	Yes	No	0	5	0	1
H:H:?3	H:H:?4	35.24	1	Yes	No	0	0	0	1
H:H:?4	R:R:T577	1.31	1	No	No	0	5	1	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	17.75
Average Nodes In Shell	11.00
Average Hubs In Shell	3.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R205	10.84	1	Yes	No	0	4	1	1
H:H:?4	R:R:R205	27.09	1	No	No	0	4	0	1
R:R:N207	R:R:N541	16.35	1	No	No	6	5	2	2
H:H:?3	R:R:N207	11.02	1	Yes	No	0	6	1	2
R:R:F539	R:R:N541	7.25	1	No	No	1	5	2	2
H:H:?3	R:R:F539	5.43	1	Yes	No	0	1	1	2
H:H:?3	R:R:N541	30.62	1	Yes	No	0	5	1	2
H:H:?3	R:R:D545	13.32	1	Yes	No	0	5	1	2
H:H:?3	H:H:?4	35.24	1	Yes	No	0	0	1	0
H:H:?4	R:R:T577	1.31	1	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	21.21
Average Nodes In Shell	8.00
Average Hubs In Shell	1.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?5	S:S:R205	17.34	1	Yes	No	0	4	0	1
H:H:?6	S:S:R205	24.92	1	No	No	0	4	1	1
S:S:N207	S:S:N541	17.71	1	No	No	6	5	1	1
S:S:C561	S:S:N207	4.72	1	Yes	No	9	6	2	1
H:H:?5	S:S:N207	8.57	1	Yes	No	0	6	0	1
S:S:F539	S:S:N541	6.04	1	No	No	1	5	1	1
S:S:F539	S:S:R544	17.1	1	No	No	1	5	1	2
H:H:?5	S:S:F539	8.69	1	Yes	No	0	1	0	1
H:H:?5	S:S:N541	23.27	1	Yes	No	0	5	0	1
S:S:D545	S:S:D578	13.31	0	No	Yes	5	7	1	2
H:H:?5	S:S:D545	10.9	1	Yes	No	0	5	0	1
H:H:?5	H:H:?6	38.55	1	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	17.89
Average Nodes In Shell	10.00
Average Hubs In Shell	3.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?5	S:S:R205	17.34	1	Yes	No	0	4	1	1
H:H:?6	S:S:R205	24.92	1	No	No	0	4	0	1
S:S:N207	S:S:N541	17.71	1	No	No	6	5	2	2
H:H:?5	S:S:N207	8.57	1	Yes	No	0	6	1	2
S:S:F539	S:S:N541	6.04	1	No	No	1	5	2	2
H:H:?5	S:S:F539	8.69	1	Yes	No	0	1	1	2
H:H:?5	S:S:N541	23.27	1	Yes	No	0	5	1	2
H:H:?5	S:S:D545	10.9	1	Yes	No	0	5	1	2
H:H:?5	H:H:?6	38.55	1	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	31.73
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N468	R:R:Q476	6.6	24	No	No	6	3	1	1
R:R:N468	R:R:T478	5.85	24	No	No	6	3	1	1
H:H:?7	R:R:N468	24.5	24	No	No	0	6	0	1
R:R:Q476	R:R:T470	4.25	24	No	No	3	5	1	2
H:H:?7	R:R:Q476	10.69	24	No	No	0	3	0	1
H:H:?7	R:R:T478	3.94	24	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.04
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N468	S:S:Q476	2.64	27	No	No	6	3	1	1
S:S:N468	S:S:T478	8.77	27	No	No	6	3	1	1
H:H:?8	S:S:N468	26.95	27	No	No	0	6	0	1
S:S:Q476	S:S:T470	5.67	27	No	No	3	5	1	2
H:H:?8	S:S:Q476	8.31	27	No	No	0	3	0	1
H:H:?8	S:S:T478	2.63	27	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	12.63
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:V486	S:S:Y514	5.05	0	No	Yes	3	4	2	1
S:S:N488	S:S:N512	4.09	28	No	Yes	4	4	1	1
S:S:N488	S:S:Y514	3.49	28	No	Yes	4	4	1	1
H:H:?9	S:S:N488	23.27	28	Yes	No	0	4	0	1
S:S:F522	S:S:Y510	12.38	0	No	No	1	3	2	1
H:H:?9	S:S:Y510	7.32	28	Yes	No	0	3	0	1
S:S:N512	S:S:Y514	4.65	28	Yes	Yes	4	4	1	1
S:S:A515	S:S:N512	4.69	0	No	Yes	4	4	2	1
H:H:?9	S:S:N512	17.15	28	Yes	Yes	0	4	0	1
S:S:V513	S:S:Y514	6.31	0	Yes	Yes	3	4	2	1
H:H:?9	S:S:Y514	8.37	28	Yes	Yes	0	4	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	14.03
Average Nodes In Shell	9.00
Average Hubs In Shell	4.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8SZI

Ion

Calcium-sensing

CaS

Homo sapiens

Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW

Gi3/Beta1/Gamma2

3.5

2024-02-07

10.1038/s41586-024-07055-2

A 2D representation of the interactions of NAG in 8SZI
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E475	R:R:K323	4.05	2	No	No	5	5	1	1
H:H:?1	R:R:K323	2.52	2	Yes	No	0	5	0	1
R:R:E475	R:R:N471	5.26	2	No	Yes	5	6	1	2
H:H:?1	R:R:E475	3.55	2	Yes	No	0	5	0	1
R:R:V486	R:R:Y514	5.05	0	No	Yes	3	4	2	1
R:R:N488	R:R:N512	4.09	2	No	Yes	4	4	1	1
R:R:N488	R:R:Y514	2.33	2	No	Yes	4	4	1	1
H:H:?1	R:R:N488	23.27	2	Yes	No	0	4	0	1
R:R:N512	R:R:Y510	2.33	2	Yes	No	4	3	1	1
R:R:F522	R:R:Y510	13.41	0	No	No	1	3	2	1
H:H:?1	R:R:Y510	11.5	2	Yes	No	0	3	0	1
R:R:N512	R:R:Y514	3.49	2	Yes	Yes	4	4	1	1
R:R:A515	R:R:N512	4.69	0	No	Yes	4	4	2	1
H:H:?1	R:R:N512	13.47	2	Yes	Yes	0	4	0	1
R:R:V513	R:R:Y514	5.05	0	No	Yes	3	4	2	1
H:H:?1	R:R:Y514	6.27	2	Yes	Yes	0	4	0	1
H:H:?1	H:H:?2	34.14	2	Yes	No	0	0	0	1
R:R:G487	R:R:Y514	1.45	0	No	Yes	6	4	2	1

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	13.53
Average Nodes In Shell	14.00
Average Hubs In Shell	4.00
Average Links In Shell	18.00
Average Links Mediated by Hubs In Shell	16.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZI
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E475	R:R:K323	4.05	2	No	No	5	5	2	2
H:H:?1	R:R:K323	2.52	2	Yes	No	0	5	1	2
H:H:?1	R:R:E475	3.55	2	Yes	No	0	5	1	2
R:R:N488	R:R:N512	4.09	2	No	Yes	4	4	2	2
R:R:N488	R:R:Y514	2.33	2	No	Yes	4	4	2	2
H:H:?1	R:R:N488	23.27	2	Yes	No	0	4	1	2
R:R:N512	R:R:Y510	2.33	2	Yes	No	4	3	2	2
H:H:?1	R:R:Y510	11.5	2	Yes	No	0	3	1	2
R:R:N512	R:R:Y514	3.49	2	Yes	Yes	4	4	2	2
H:H:?1	R:R:N512	13.47	2	Yes	Yes	0	4	1	2
H:H:?1	R:R:Y514	6.27	2	Yes	Yes	0	4	1	2
H:H:?1	H:H:?2	34.14	2	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	34.14
Average Nodes In Shell	8.00
Average Hubs In Shell	3.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZI
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R205	10.84	30	Yes	No	0	4	0	1
H:H:?4	R:R:R205	21.67	30	No	No	0	4	1	1
R:R:N207	R:R:N541	16.35	30	No	No	6	5	1	1
R:R:C561	R:R:N207	6.3	0	No	No	9	6	2	1
H:H:?3	R:R:N207	9.8	30	Yes	No	0	6	0	1
R:R:F539	R:R:N541	7.25	30	No	No	1	5	1	1
R:R:F539	R:R:R544	23.52	30	No	No	1	5	1	2
H:H:?3	R:R:F539	5.43	30	Yes	No	0	1	0	1
H:H:?3	R:R:N541	26.95	30	Yes	No	0	5	0	1
R:R:D545	R:R:D578	10.65	0	No	No	5	7	1	2
H:H:?3	R:R:D545	9.68	30	Yes	No	0	5	0	1
H:H:?3	H:H:?4	30.84	30	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.59
Average Nodes In Shell	10.00
Average Hubs In Shell	1.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZI
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R205	10.84	30	Yes	No	0	4	1	1
H:H:?4	R:R:R205	21.67	30	No	No	0	4	0	1
R:R:N207	R:R:N541	16.35	30	No	No	6	5	2	2
H:H:?3	R:R:N207	9.8	30	Yes	No	0	6	1	2
R:R:F539	R:R:N541	7.25	30	No	No	1	5	2	2
H:H:?3	R:R:F539	5.43	30	Yes	No	0	1	1	2
H:H:?3	R:R:N541	26.95	30	Yes	No	0	5	1	2
H:H:?3	R:R:D545	9.68	30	Yes	No	0	5	1	2
H:H:?3	H:H:?4	30.84	30	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	26.26
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZI
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?5	S:S:R205	21.67	33	Yes	No	0	4	0	1
H:H:?6	S:S:R205	23.84	33	No	No	0	4	1	1
S:S:N207	S:S:N541	14.98	33	No	No	6	5	1	1
S:S:C561	S:S:N207	6.3	0	No	No	9	6	2	1
H:H:?5	S:S:N207	4.9	33	Yes	No	0	6	0	1
S:S:F539	S:S:N541	6.04	33	No	No	1	5	1	1
S:S:F539	S:S:R544	19.24	33	No	No	1	5	1	2
H:H:?5	S:S:F539	7.6	33	Yes	No	0	1	0	1
H:H:?5	S:S:N541	28.17	33	Yes	No	0	5	0	1
S:S:D545	S:S:D578	14.64	0	No	Yes	5	7	1	2
H:H:?5	S:S:D545	20.58	33	Yes	No	0	5	0	1
H:H:?5	H:H:?6	36.34	33	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	19.88
Average Nodes In Shell	10.00
Average Hubs In Shell	2.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	7.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZI
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?5	S:S:R205	21.67	33	Yes	No	0	4	1	1
H:H:?6	S:S:R205	23.84	33	No	No	0	4	0	1
S:S:N207	S:S:N541	14.98	33	No	No	6	5	2	2
H:H:?5	S:S:N207	4.9	33	Yes	No	0	6	1	2
S:S:F539	S:S:N541	6.04	33	No	No	1	5	2	2
H:H:?5	S:S:F539	7.6	33	Yes	No	0	1	1	2
H:H:?5	S:S:N541	28.17	33	Yes	No	0	5	1	2
H:H:?5	S:S:D545	20.58	33	Yes	No	0	5	1	2
H:H:?5	H:H:?6	36.34	33	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	30.09
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZI
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N468	R:R:Q476	5.28	42	No	No	6	3	1	1
R:R:N468	R:R:T478	5.85	42	No	No	6	3	1	1
H:H:?7	R:R:N468	23.27	42	No	No	0	6	0	1
R:R:Q476	R:R:T470	2.83	42	No	No	3	5	1	2
H:H:?7	R:R:Q476	8.31	42	No	No	0	3	0	1
H:H:?7	R:R:T478	5.26	42	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	12.28
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZI
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N468	S:S:Q476	2.64	47	No	No	6	3	1	1
S:S:N468	S:S:T478	7.31	47	No	No	6	3	1	1
H:H:?8	S:S:N468	26.95	47	No	No	0	6	0	1
S:S:Q476	S:S:T470	5.67	47	No	No	3	5	1	2
H:H:?8	S:S:Q476	3.56	47	No	No	0	3	0	1
H:H:?8	S:S:T478	2.63	47	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	11.05
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8SZI
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:E475	S:S:K323	2.7	1	No	No	5	5	2	1
H:H:?9	S:S:K323	2.52	46	Yes	No	0	5	0	1
S:S:V486	S:S:Y514	6.31	0	No	Yes	3	4	2	1
S:S:N488	S:S:N512	2.72	46	No	Yes	4	4	1	1
S:S:N488	S:S:Y514	3.49	46	No	Yes	4	4	1	1
H:H:?9	S:S:N488	29.4	46	Yes	No	0	4	0	1
S:S:F522	S:S:Y510	12.38	0	No	No	1	3	2	1
H:H:?9	S:S:Y510	6.27	46	Yes	No	0	3	0	1
S:S:N512	S:S:Y514	4.65	46	Yes	Yes	4	4	1	1
S:S:A515	S:S:N512	4.69	0	No	Yes	4	4	2	1
H:H:?9	S:S:N512	15.92	46	Yes	Yes	0	4	0	1
S:S:V513	S:S:Y514	8.83	0	No	Yes	3	4	2	1
H:H:?9	S:S:Y514	11.5	46	Yes	Yes	0	4	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	13.12
Average Nodes In Shell	11.00
Average Hubs In Shell	3.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8U1U

Protein

Chemokine

CCR8

Homo Sapiens

CCL1

Gi1/Beta1/Gamma2

3.1

2023-12-20

10.1038/s41467-023-43601-8

A 2D representation of the interactions of NAG in 8U1U
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Shell	Node2Shell
L:L:L62	L:L:Y50	9.38	14	Yes	No	2	2
L:L:R85	L:L:Y50	8.23	14	Yes	No	1	2
H:H:?900	L:L:N52	28.17	0	No	No	0	1
L:L:L62	L:L:R85	4.86	14	Yes	Yes	2	1
L:L:R85	L:L:T77	5.17	14	Yes	No	1	2
L:L:Q82	L:L:R85	7.01	0	No	Yes	2	1
H:H:?900	L:L:R85	9.75	0	No	Yes	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	18.96
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8WPG

Ion

Calcium-sensing

CaS

Homo sapiens

Tryptophan; Cinacalcet; PO4; Ca

2.7

2023-11-22

10.1038/s41422-023-00892-2

A 2D representation of the interactions of NAG in 8WPG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?6	S:S:R205	9.75	4	Yes	No	0	4	0	1
H:H:?7	S:S:R205	10.84	4	No	No	0	4	1	1
S:S:N207	S:S:N541	16.35	4	No	No	6	5	1	1
S:S:C561	S:S:N207	9.45	4	No	No	9	6	2	1
H:H:?6	S:S:N207	15.92	4	Yes	No	0	6	0	1
S:S:F539	S:S:N541	8.46	4	No	No	1	5	1	1
S:S:F539	S:S:R544	25.66	4	No	No	1	5	1	2
H:H:?6	S:S:F539	5.43	4	Yes	No	0	1	0	1
H:H:?6	S:S:N541	28.17	4	Yes	No	0	5	0	1
S:S:D545	S:S:D578	7.98	0	No	No	5	7	1	2
H:H:?6	S:S:D545	6.05	4	Yes	No	0	5	0	1
H:H:?6	H:H:?7	36.34	4	Yes	No	0	0	0	1
S:S:D545	S:S:T577	2.89	0	No	No	5	5	1	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	16.94
Average Nodes In Shell	11.00
Average Hubs In Shell	1.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8WPG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?6	S:S:R205	9.75	4	Yes	No	0	4	1	1
H:H:?7	S:S:R205	10.84	4	No	No	0	4	0	1
S:S:N207	S:S:N541	16.35	4	No	No	6	5	2	2
H:H:?6	S:S:N207	15.92	4	Yes	No	0	6	1	2
S:S:F539	S:S:N541	8.46	4	No	No	1	5	2	2
H:H:?6	S:S:F539	5.43	4	Yes	No	0	1	1	2
H:H:?6	S:S:N541	28.17	4	Yes	No	0	5	1	2
H:H:?6	S:S:D545	6.05	4	Yes	No	0	5	1	2
H:H:?6	H:H:?7	36.34	4	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	23.59
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8WPG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:V486	S:S:Y514	5.05	0	No	Yes	3	4	2	1
S:S:N488	S:S:N512	4.09	21	No	Yes	4	4	1	1
S:S:N488	S:S:Y514	4.65	21	No	Yes	4	4	1	1
H:H:?8	S:S:N488	28.17	21	Yes	No	0	4	0	1
S:S:F522	S:S:Y510	14.44	0	No	No	1	3	2	1
H:H:?8	S:S:Y510	10.46	21	Yes	No	0	3	0	1
S:S:N512	S:S:Y514	3.49	21	Yes	Yes	4	4	1	1
S:S:A515	S:S:N512	4.69	0	No	Yes	4	4	2	1
H:H:?8	S:S:N512	17.15	21	Yes	Yes	0	4	0	1
S:S:V513	S:S:Y514	5.05	0	No	Yes	3	4	2	1
H:H:?8	S:S:Y514	16.73	21	Yes	Yes	0	4	0	1
H:H:?8	H:H:?9	41.85	21	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	22.87
Average Nodes In Shell	10.00
Average Hubs In Shell	3.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8WPG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N488	S:S:N512	4.09	21	No	Yes	4	4	2	2
S:S:N488	S:S:Y514	4.65	21	No	Yes	4	4	2	2
H:H:?8	S:S:N488	28.17	21	Yes	No	0	4	1	2
H:H:?8	S:S:Y510	10.46	21	Yes	No	0	3	1	2
S:S:N512	S:S:Y514	3.49	21	Yes	Yes	4	4	2	2
H:H:?8	S:S:N512	17.15	21	Yes	Yes	0	4	1	2
H:H:?8	S:S:Y514	16.73	21	Yes	Yes	0	4	1	2
H:H:?8	H:H:?9	41.85	21	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	41.85
Average Nodes In Shell	6.00
Average Hubs In Shell	3.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8WPG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V486	R:R:Y514	3.79	0	No	Yes	3	4	2	1
R:R:N488	R:R:N512	6.81	19	Yes	Yes	4	4	1	1
R:R:N488	R:R:V513	4.43	19	Yes	No	4	3	1	2
R:R:N488	R:R:Y514	8.14	19	Yes	Yes	4	4	1	1
H:H:?10	R:R:N488	25.72	19	Yes	Yes	0	4	0	1
R:R:F522	R:R:Y510	13.41	0	No	No	1	3	2	1
H:H:?10	R:R:Y510	8.37	19	Yes	No	0	3	0	1
R:R:N512	R:R:Y514	6.98	19	Yes	Yes	4	4	1	1
R:R:A515	R:R:N512	4.69	0	No	Yes	4	4	2	1
H:H:?10	R:R:N512	17.15	19	Yes	Yes	0	4	0	1
R:R:V513	R:R:Y514	8.83	19	No	Yes	3	4	2	1
H:H:?10	R:R:Y514	17.78	19	Yes	Yes	0	4	0	1
H:H:?10	H:H:?11	42.95	19	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	22.39
Average Nodes In Shell	10.00
Average Hubs In Shell	4.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8WPG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N488	R:R:N512	6.81	19	Yes	Yes	4	4	2	2
R:R:N488	R:R:Y514	8.14	19	Yes	Yes	4	4	2	2
H:H:?10	R:R:N488	25.72	19	Yes	Yes	0	4	1	2
H:H:?10	R:R:Y510	8.37	19	Yes	No	0	3	1	2
R:R:N512	R:R:Y514	6.98	19	Yes	Yes	4	4	2	2
H:H:?10	R:R:N512	17.15	19	Yes	Yes	0	4	1	2
H:H:?10	R:R:Y514	17.78	19	Yes	Yes	0	4	1	2
H:H:?10	H:H:?11	42.95	19	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	42.95
Average Nodes In Shell	6.00
Average Hubs In Shell	4.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8WPG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?12	R:R:R205	6.5	10	Yes	No	0	4	0	1
H:H:?13	R:R:R205	21.67	10	No	No	0	4	1	1
R:R:N207	R:R:N541	16.35	10	No	No	6	5	1	1
R:R:C561	R:R:N207	7.87	10	No	No	9	6	2	1
H:H:?12	R:R:N207	11.02	10	Yes	No	0	6	0	1
R:R:F539	R:R:N541	7.25	10	No	No	1	5	1	1
R:R:F539	R:R:R544	24.59	10	No	No	1	5	1	2
H:H:?12	R:R:F539	5.43	10	Yes	No	0	1	0	1
H:H:?12	R:R:N541	24.5	10	Yes	No	0	5	0	1
R:R:D545	R:R:T577	4.34	10	No	No	5	5	1	2
R:R:D545	R:R:D578	7.98	10	No	No	5	7	1	2
H:H:?12	R:R:D545	10.9	10	Yes	No	0	5	0	1
R:R:D578	R:R:T577	5.78	10	No	No	7	5	2	2
H:H:?12	H:H:?13	38.55	10	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	16.15
Average Nodes In Shell	11.00
Average Hubs In Shell	1.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8WPG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?12	R:R:R205	6.5	10	Yes	No	0	4	1	1
H:H:?13	R:R:R205	21.67	10	No	No	0	4	0	1
R:R:N207	R:R:N541	16.35	10	No	No	6	5	2	2
H:H:?12	R:R:N207	11.02	10	Yes	No	0	6	1	2
R:R:F539	R:R:N541	7.25	10	No	No	1	5	2	2
H:H:?12	R:R:F539	5.43	10	Yes	No	0	1	1	2
H:H:?12	R:R:N541	24.5	10	Yes	No	0	5	1	2
H:H:?12	R:R:D545	10.9	10	Yes	No	0	5	1	2
H:H:?12	H:H:?13	38.55	10	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	30.11
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8WPG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:E257	S:S:R286	11.63	No	Yes	3	4	1	2
H:H:?3	S:S:E257	3.55	No	No	0	3	0	1
H:H:?3	S:S:N261	33.07	No	No	0	4	0	1
S:S:E257	S:S:Q253	1.27	No	No	3	3	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.31
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	1.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8WPG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:H312	S:S:V284	5.54	17	Yes	No	3	3	1	2
S:S:V284	S:S:V313	6.41	17	No	No	3	3	2	2
S:S:H312	S:S:N287	7.65	17	Yes	No	3	6	1	1
H:H:?4	S:S:N287	33.07	17	No	No	0	6	0	1
S:S:G290	S:S:T289	3.64	0	No	No	4	5	2	1
H:H:?4	S:S:T289	6.57	17	No	No	0	5	0	1
S:S:H312	S:S:V313	6.92	17	Yes	No	3	3	1	2
H:H:?4	S:S:H312	3.44	17	No	Yes	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	14.36
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8WPG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N468	S:S:Q476	5.28	33	No	No	6	3	1	1
S:S:N468	S:S:T478	10.24	33	No	No	6	3	1	2
H:H:?5	S:S:N468	23.27	33	No	No	0	6	0	1
S:S:Q476	S:S:T470	5.67	33	No	No	3	5	1	2
H:H:?5	S:S:Q476	7.12	33	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.20
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8WPG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E257	R:R:Q253	5.1	20	No	No	3	3	1	2
R:R:Q253	R:R:R286	8.18	20	No	Yes	3	4	2	2
R:R:E257	R:R:R286	11.63	20	No	Yes	3	4	1	2
H:H:?1	R:R:E257	3.55	0	No	No	0	3	0	1
H:H:?1	R:R:N261	26.95	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.25
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	2.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8WPG
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H312	R:R:N287	5.1	3	No	No	3	6	2	1
H:H:?2	R:R:N287	29.4	0	No	No	0	6	0	1
R:R:G290	R:R:T289	3.64	0	No	No	4	5	2	1
H:H:?2	R:R:T289	6.57	0	No	No	0	5	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	17.98
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	4.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8WPU

Ion

Calcium-sensing

CaS

Homo sapiens

Tryptophan; Cinacalcet; PO4; Ca

chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2

3.1

2023-11-22

10.1038/s41422-023-00892-2

A 2D representation of the interactions of NAG in 8WPU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:E202	S:S:R205	5.82	2	No	No	5	4	2	1
H:H:?2	S:S:E202	5.91	2	No	No	0	5	1	2
H:H:?1	S:S:R205	6.5	2	Yes	No	0	4	0	1
H:H:?2	S:S:R205	5.42	2	No	No	0	4	1	1
S:S:N207	S:S:N541	13.62	2	No	No	6	5	1	1
S:S:C561	S:S:N207	11.02	2	Yes	No	9	6	2	1
H:H:?1	S:S:N207	11.02	2	Yes	No	0	6	0	1
S:S:F539	S:S:K265	2.48	2	Yes	No	1	5	1	2
S:S:F539	S:S:N541	8.46	2	Yes	No	1	5	1	1
S:S:F539	S:S:R544	2.14	2	Yes	No	1	5	1	2
H:H:?1	S:S:F539	7.6	2	Yes	Yes	0	1	0	1
H:H:?1	S:S:N541	28.17	2	Yes	No	0	5	0	1
S:S:D545	S:S:T577	4.34	0	No	No	5	5	1	2
H:H:?1	S:S:D545	6.05	2	Yes	No	0	5	0	1
H:H:?1	H:H:?2	33.04	2	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	15.40
Average Nodes In Shell	12.00
Average Hubs In Shell	3.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8WPU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:E202	S:S:R205	5.82	2	No	No	5	4	1	1
S:S:E202	S:S:I235	2.73	2	No	Yes	5	7	1	2
H:H:?2	S:S:E202	5.91	2	No	No	0	5	0	1
H:H:?1	S:S:R205	6.5	2	Yes	No	0	4	1	1
H:H:?2	S:S:R205	5.42	2	No	No	0	4	0	1
S:S:N207	S:S:N541	13.62	2	No	No	6	5	2	2
H:H:?1	S:S:N207	11.02	2	Yes	No	0	6	1	2
S:S:F539	S:S:N541	8.46	2	Yes	No	1	5	2	2
H:H:?1	S:S:F539	7.6	2	Yes	Yes	0	1	1	2
H:H:?1	S:S:N541	28.17	2	Yes	No	0	5	1	2
H:H:?1	S:S:D545	6.05	2	Yes	No	0	5	1	2
H:H:?1	H:H:?2	33.04	2	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	14.79
Average Nodes In Shell	9.00
Average Hubs In Shell	3.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8WPU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R205	8.67	1	Yes	No	0	4	0	1
H:H:?4	R:R:R205	19.51	1	No	No	0	4	1	1
R:R:N207	R:R:N541	12.26	1	No	Yes	6	5	1	1
R:R:C561	R:R:N207	7.87	1	Yes	No	9	6	2	1
H:H:?3	R:R:N207	15.92	1	Yes	No	0	6	0	1
R:R:F539	R:R:K265	2.48	1	Yes	No	1	5	1	2
R:R:F539	R:R:N541	8.46	1	Yes	Yes	1	5	1	1
R:R:F539	R:R:R544	18.17	1	Yes	No	1	5	1	2
H:H:?3	R:R:F539	5.43	1	Yes	Yes	0	1	0	1
R:R:D545	R:R:N541	2.69	1	Yes	Yes	5	5	1	1
H:H:?3	R:R:N541	31.85	1	Yes	Yes	0	5	0	1
R:R:D545	R:R:T577	2.89	1	Yes	No	5	5	1	2
R:R:D545	R:R:D578	14.64	1	Yes	No	5	7	1	2
H:H:?3	R:R:D545	3.63	1	Yes	Yes	0	5	0	1
H:H:?3	H:H:?4	35.24	1	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	16.79
Average Nodes In Shell	12.00
Average Hubs In Shell	5.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	14.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8WPU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R205	8.67	1	Yes	No	0	4	1	1
H:H:?4	R:R:R205	19.51	1	No	No	0	4	0	1
R:R:N207	R:R:N541	12.26	1	No	Yes	6	5	2	2
H:H:?3	R:R:N207	15.92	1	Yes	No	0	6	1	2
R:R:F539	R:R:N541	8.46	1	Yes	Yes	1	5	2	2
H:H:?3	R:R:F539	5.43	1	Yes	Yes	0	1	1	2
R:R:D545	R:R:N541	2.69	1	Yes	Yes	5	5	2	2
H:H:?3	R:R:N541	31.85	1	Yes	Yes	0	5	1	2
H:H:?3	R:R:D545	3.63	1	Yes	Yes	0	5	1	2
H:H:?3	H:H:?4	35.24	1	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	27.38
Average Nodes In Shell	7.00
Average Hubs In Shell	4.00
Average Links In Shell	10.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8WPU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:E241	S:S:H254	4.92	2	No	No	5	3	2	1
S:S:E241	S:S:V258	9.98	2	No	No	5	4	2	2
S:S:E257	S:S:Q253	2.55	38	No	No	3	3	1	2
S:S:Q253	S:S:R286	5.84	38	No	Yes	3	4	2	2
S:S:H254	S:S:V258	4.15	2	No	No	3	4	1	2
H:H:?5	S:S:H254	2.29	0	No	No	0	3	0	1
S:S:E257	S:S:R286	3.49	38	No	Yes	3	4	1	2
H:H:?5	S:S:E257	3.55	0	No	No	0	3	0	1
S:S:N261	S:S:Q260	2.64	0	No	No	4	5	1	2
S:S:Q260	S:S:R286	5.84	0	No	Yes	5	4	2	2
H:H:?5	S:S:N261	24.5	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	10.11
Average Nodes In Shell	9.00
Average Hubs In Shell	1.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	3.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8WPU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N287	S:S:T289	4.39	0	No	No	6	5	1	2
S:S:H312	S:S:N287	5.1	8	No	No	3	6	2	1
H:H:?6	S:S:N287	29.4	0	No	No	0	6	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	29.40
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8WPU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N468	S:S:Q476	6.6	28	No	No	6	3	1	1
S:S:N468	S:S:T478	5.85	28	No	No	6	3	1	1
H:H:?7	S:S:N468	29.4	28	No	No	0	6	0	1
S:S:Q476	S:S:T470	5.67	28	No	No	3	5	1	2
H:H:?7	S:S:Q476	5.94	28	No	No	0	3	0	1
H:H:?7	S:S:T478	3.94	28	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.09
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8WPU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:G549	S:S:T596	1.82	0	No	Yes	9	5	2	1
S:S:N592	S:S:T596	2.92	29	Yes	Yes	7	5	1	1
S:S:N592	S:S:S597	10.43	29	Yes	No	7	1	1	2
S:S:I599	S:S:N592	11.33	0	No	Yes	4	7	2	1
H:H:?8	S:S:N592	7.35	29	Yes	Yes	0	7	0	1
H:H:?8	S:S:E593	10.64	29	Yes	No	0	2	0	1
H:H:?8	S:S:N594	30.62	29	Yes	No	0	3	0	1
S:S:S597	S:S:T596	3.2	29	No	Yes	1	5	2	1
H:H:?8	S:S:T596	15.78	29	Yes	Yes	0	5	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	16.10
Average Nodes In Shell	8.00
Average Hubs In Shell	3.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8WPU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E241	R:R:H254	8.62	No	No	5	3	2	1
R:R:E257	R:R:Q253	2.55	No	No	3	3	1	2
H:H:?9	R:R:H254	2.29	No	No	0	3	0	1
H:H:?9	R:R:E257	5.91	No	No	0	3	0	1
H:H:?9	R:R:N261	24.5	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	10.90
Average Nodes In Shell	6.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8WPU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N287	R:R:T289	4.39	0	No	No	6	5	1	2
R:R:H312	R:R:N287	5.1	1	No	No	3	6	2	1
H:H:?10	R:R:N287	28.17	0	No	No	0	6	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	28.17
Average Nodes In Shell	4.00
Average Hubs In Shell	0.00
Average Links In Shell	3.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8WPU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E475	R:R:K323	2.7	1	Yes	No	5	5	1	1
H:H:?11	R:R:K323	6.29	1	Yes	No	0	5	0	1
R:R:M473	R:R:N471	2.8	1	Yes	Yes	4	6	2	2
R:R:E475	R:R:N471	5.26	1	Yes	Yes	5	6	1	2
R:R:E475	R:R:M473	2.71	1	Yes	Yes	5	4	1	2
H:H:?11	R:R:E475	4.73	1	Yes	Yes	0	5	0	1
R:R:V486	R:R:V513	3.21	1	No	Yes	3	3	2	2
R:R:V486	R:R:Y514	5.05	1	No	Yes	3	4	2	1
R:R:N488	R:R:N512	5.45	1	No	Yes	4	4	1	1
R:R:N488	R:R:Y514	6.98	1	No	Yes	4	4	1	1
H:H:?11	R:R:N488	22.05	1	Yes	No	0	4	0	1
R:R:N512	R:R:Y510	2.33	1	Yes	No	4	3	1	1
R:R:F522	R:R:Y510	17.54	0	No	No	1	3	2	1
H:H:?11	R:R:Y510	8.37	1	Yes	No	0	3	0	1
R:R:N512	R:R:Y514	8.14	1	Yes	Yes	4	4	1	1
R:R:A515	R:R:N512	4.69	0	No	Yes	4	4	2	1
H:H:?11	R:R:N512	17.15	1	Yes	Yes	0	4	0	1
R:R:V513	R:R:Y514	7.57	1	Yes	Yes	3	4	2	1
H:H:?11	R:R:Y514	14.64	1	Yes	Yes	0	4	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	12.20
Average Nodes In Shell	13.00
Average Hubs In Shell	7.00
Average Links In Shell	19.00
Average Links Mediated by Hubs In Shell	18.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8WPU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N468	R:R:T478	5.85	0	No	No	6	3	1	2
H:H:?12	R:R:N468	25.72	0	No	No	0	6	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	25.72
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 8WPU
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:A548	R:R:T596	3.36	0	No	No	4	5	2	1
R:R:E593	R:R:N592	3.94	31	No	No	2	7	1	1
H:H:?13	R:R:N592	11.02	31	Yes	No	0	7	0	1
R:R:E593	R:R:N594	6.57	31	No	No	2	3	1	1
H:H:?13	R:R:E593	13	31	Yes	No	0	2	0	1
H:H:?13	R:R:N594	28.17	31	Yes	No	0	3	0	1
H:H:?13	R:R:T596	7.89	31	Yes	No	0	5	0	1
R:R:N592	R:R:S597	1.49	31	No	No	7	1	1	2

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	15.02
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	8.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

9AUC

Peptide

Calcitonin

Homo Sapiens

Calcitonin gene-related peptide-1

Gs/Beta1/Gamma2; RAMP1

2.4

2024-04-24

10.1021/acs.biochem.4c00114

A 2D representation of the interactions of NAG in 9AUC
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N73	R:R:R74	3.62	0	No	No	4	4	1	2
H:H:?2	R:R:N73	31.85	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	31.85
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AUC
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:N125	26.95	0	No	No	0	7	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	26.95
Average Nodes In Shell	2.00
Average Hubs In Shell	0.00
Average Links In Shell	1.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AUC
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?37	R:R:W128	6.38	1	Yes	Yes	0	5	2	1
R:R:N130	R:R:T109	4.39	1	Yes	No	8	5	1	2
R:R:H121	R:R:W128	19.04	0	No	Yes	4	5	2	1
R:R:N130	R:R:W128	7.91	1	Yes	Yes	8	5	1	1
H:H:?4	R:R:W128	7.11	1	Yes	Yes	0	5	0	1
R:R:N130	R:R:T132	4.39	1	Yes	No	8	6	1	2
R:R:M133	R:R:N130	5.61	1	No	Yes	5	8	1	1
H:H:?4	R:R:N130	28.17	1	Yes	Yes	0	8	0	1
H:H:?4	R:R:M133	7.57	1	Yes	No	0	5	0	1
R:R:E106	R:R:M133	2.71	1	Yes	No	4	5	2	1
H:H:?4	R:R:F119	2.17	1	Yes	No	0	4	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	11.26
Average Nodes In Shell	10.00
Average Hubs In Shell	5.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	11.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

9AXF

Ion

Calcium-sensing

CaS

Homo Sapiens

Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4

chim(NtGi1-Gs-CtGq)/Beta1/Gamma2

3.5

2024-04-17

10.1038/s41586-024-07331-1

A 2D representation of the interactions of NAG in 9AXF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:K323	5.03	1	Yes	No	0	5	0	1
R:R:V486	R:R:Y514	3.79	1	No	No	3	4	2	1
R:R:N488	R:R:N512	4.09	1	No	Yes	4	4	1	1
H:H:?1	R:R:N488	23.27	1	Yes	No	0	4	0	1
R:R:N512	R:R:Y510	2.33	1	Yes	No	4	3	1	1
R:R:F522	R:R:Y510	16.5	0	No	No	1	3	2	1
H:H:?1	R:R:Y510	10.46	1	Yes	No	0	3	0	1
R:R:N512	R:R:Y514	3.49	1	Yes	No	4	4	1	1
R:R:A515	R:R:N512	4.69	0	No	Yes	4	4	2	1
H:H:?1	R:R:N512	14.7	1	Yes	Yes	0	4	0	1
H:H:?1	R:R:Y514	5.23	1	Yes	No	0	4	0	1
H:H:?1	H:H:?2	38.55	1	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	16.21
Average Nodes In Shell	10.00
Average Hubs In Shell	2.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	10.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AXF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?1	R:R:K323	5.03	1	Yes	No	0	5	1	2
R:R:N488	R:R:N512	4.09	1	No	Yes	4	4	2	2
H:H:?1	R:R:N488	23.27	1	Yes	No	0	4	1	2
R:R:N512	R:R:Y510	2.33	1	Yes	No	4	3	2	2
H:H:?1	R:R:Y510	10.46	1	Yes	No	0	3	1	2
R:R:N512	R:R:Y514	3.49	1	Yes	No	4	4	2	2
H:H:?1	R:R:N512	14.7	1	Yes	Yes	0	4	1	2
H:H:?1	R:R:Y514	5.23	1	Yes	No	0	4	1	2
H:H:?1	H:H:?2	38.55	1	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	38.55
Average Nodes In Shell	7.00
Average Hubs In Shell	2.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AXF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R205	6.5	1	Yes	No	0	4	0	1
H:H:?4	R:R:R205	8.67	1	No	No	0	4	1	1
R:R:N207	R:R:N541	13.62	1	No	No	6	5	1	1
R:R:C561	R:R:N207	11.02	0	No	No	9	6	2	1
H:H:?3	R:R:N207	18.37	1	Yes	No	0	6	0	1
R:R:F539	R:R:N541	10.87	1	No	No	1	5	1	1
R:R:F539	R:R:R544	20.31	1	No	No	1	5	1	2
H:H:?3	R:R:F539	3.26	1	Yes	No	0	1	0	1
H:H:?3	R:R:N541	26.95	1	Yes	No	0	5	0	1
R:R:D545	R:R:T577	2.89	1	No	No	5	5	1	2
R:R:D545	R:R:D578	3.99	1	No	Yes	5	7	1	2
H:H:?3	R:R:D545	3.63	1	Yes	No	0	5	0	1
R:R:D578	R:R:T577	2.89	1	Yes	No	7	5	2	2
H:H:?3	H:H:?4	38.55	1	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	16.21
Average Nodes In Shell	11.00
Average Hubs In Shell	2.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AXF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	R:R:R205	6.5	1	Yes	No	0	4	1	1
H:H:?4	R:R:R205	8.67	1	No	No	0	4	0	1
R:R:N207	R:R:N541	13.62	1	No	No	6	5	2	2
H:H:?3	R:R:N207	18.37	1	Yes	No	0	6	1	2
R:R:F539	R:R:N541	10.87	1	No	No	1	5	2	2
H:H:?3	R:R:F539	3.26	1	Yes	No	0	1	1	2
H:H:?3	R:R:N541	26.95	1	Yes	No	0	5	1	2
H:H:?3	R:R:D545	3.63	1	Yes	No	0	5	1	2
H:H:?3	H:H:?4	38.55	1	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	23.61
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AXF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:V486	S:S:V513	3.21	1	No	Yes	3	3	2	2
S:S:V486	S:S:Y514	6.31	1	No	Yes	3	4	2	1
S:S:N488	S:S:N512	6.81	1	No	Yes	4	4	1	1
S:S:N488	S:S:Y514	3.49	1	No	Yes	4	4	1	1
H:H:?5	S:S:N488	26.95	1	Yes	No	0	4	0	1
S:S:N512	S:S:Y510	2.33	1	Yes	No	4	3	1	1
S:S:F522	S:S:Y510	10.32	0	No	No	1	3	2	1
H:H:?5	S:S:Y510	10.46	1	Yes	No	0	3	0	1
S:S:N512	S:S:Y514	6.98	1	Yes	Yes	4	4	1	1
S:S:A515	S:S:N512	3.13	0	No	Yes	4	4	2	1
H:H:?5	S:S:N512	17.15	1	Yes	Yes	0	4	0	1
S:S:V513	S:S:Y514	7.57	1	Yes	Yes	3	4	2	1
H:H:?5	S:S:Y514	11.5	1	Yes	Yes	0	4	0	1
H:H:?5	H:H:?6	40.75	1	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	21.36
Average Nodes In Shell	10.00
Average Hubs In Shell	4.00
Average Links In Shell	14.00
Average Links Mediated by Hubs In Shell	13.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AXF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N488	S:S:N512	6.81	1	No	Yes	4	4	2	2
S:S:N488	S:S:Y514	3.49	1	No	Yes	4	4	2	2
H:H:?5	S:S:N488	26.95	1	Yes	No	0	4	1	2
S:S:N512	S:S:Y510	2.33	1	Yes	No	4	3	2	2
H:H:?5	S:S:Y510	10.46	1	Yes	No	0	3	1	2
S:S:N512	S:S:Y514	6.98	1	Yes	Yes	4	4	2	2
H:H:?5	S:S:N512	17.15	1	Yes	Yes	0	4	1	2
H:H:?5	S:S:Y514	11.5	1	Yes	Yes	0	4	1	2
H:H:?5	H:H:?6	40.75	1	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	40.75
Average Nodes In Shell	6.00
Average Hubs In Shell	3.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AXF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?7	S:S:R205	10.84	7	Yes	No	0	4	0	1
H:H:?8	S:S:R205	7.59	7	No	No	0	4	1	1
S:S:N207	S:S:N541	17.71	7	No	No	6	5	1	1
S:S:C561	S:S:N207	4.72	0	No	No	9	6	2	1
H:H:?7	S:S:N207	11.02	7	Yes	No	0	6	0	1
S:S:F539	S:S:N541	7.25	7	No	No	1	5	1	1
S:S:F539	S:S:R544	26.72	7	No	No	1	5	1	2
H:H:?7	S:S:F539	5.43	7	Yes	No	0	1	0	1
H:H:?7	S:S:N541	29.4	7	Yes	No	0	5	0	1
H:H:?8	S:S:D578	2.42	7	No	No	0	7	1	2
H:H:?7	H:H:?8	40.75	7	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	19.49
Average Nodes In Shell	9.00
Average Hubs In Shell	1.00
Average Links In Shell	11.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AXF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?7	S:S:R205	10.84	7	Yes	No	0	4	1	1
H:H:?8	S:S:R205	7.59	7	No	No	0	4	0	1
S:S:N207	S:S:N541	17.71	7	No	No	6	5	2	2
H:H:?7	S:S:N207	11.02	7	Yes	No	0	6	1	2
S:S:F539	S:S:N541	7.25	7	No	No	1	5	2	2
H:H:?7	S:S:F539	5.43	7	Yes	No	0	1	1	2
H:H:?7	S:S:N541	29.4	7	Yes	No	0	5	1	2
S:S:D545	S:S:T577	2.89	7	No	No	5	5	2	2
S:S:D545	S:S:D578	9.31	7	No	No	5	7	2	1
S:S:D578	S:S:T577	2.89	7	No	No	7	5	1	2
H:H:?8	S:S:D578	2.42	7	No	No	0	7	0	1
H:H:?7	H:H:?8	40.75	7	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	16.92
Average Nodes In Shell	9.00
Average Hubs In Shell	1.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AXF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E241	R:R:F239	2.33	1	Yes	Yes	5	6	2	2
R:R:F239	R:R:V258	5.24	1	Yes	Yes	6	4	2	1
R:R:E241	R:R:H254	6.15	1	Yes	No	5	3	2	1
R:R:E241	R:R:V258	12.84	1	Yes	Yes	5	4	2	1
R:R:H254	R:R:V258	4.15	1	No	Yes	3	4	1	1
H:H:?9	R:R:H254	2.29	1	Yes	No	0	3	0	1
H:H:?9	R:R:E257	22.46	1	Yes	No	0	3	0	1
H:H:?9	R:R:V258	3.99	1	Yes	Yes	0	4	0	1
H:H:?9	R:R:N261	29.4	1	Yes	No	0	4	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	14.54
Average Nodes In Shell	7.00
Average Hubs In Shell	4.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AXF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H312	R:R:V284	2.77	1	Yes	Yes	3	3	1	2
R:R:V284	R:R:V313	6.41	1	Yes	Yes	3	3	2	2
R:R:N287	R:R:T289	5.85	1	No	No	6	5	1	1
R:R:H312	R:R:N287	7.65	1	Yes	No	3	6	1	1
H:H:?10	R:R:N287	31.85	1	No	No	0	6	0	1
R:R:G290	R:R:T289	1.82	0	No	No	4	5	2	1
H:H:?10	R:R:T289	2.63	1	No	No	0	5	0	1
R:R:H312	R:R:V313	5.54	1	Yes	Yes	3	3	1	2
H:H:?10	R:R:H312	3.44	1	No	Yes	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	12.64
Average Nodes In Shell	7.00
Average Hubs In Shell	3.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AXF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N468	R:R:Q476	5.28	15	No	No	6	3	1	1
R:R:N468	R:R:T478	5.85	15	No	No	6	3	1	2
H:H:?11	R:R:N468	28.17	15	No	No	0	6	0	1
R:R:Q476	R:R:T470	9.92	15	No	No	3	5	1	2
H:H:?11	R:R:Q476	15.43	15	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	21.80
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AXF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N594	R:R:T596	4.39	0	No	No	3	5	1	2
H:H:?12	R:R:N594	25.72	0	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	25.72
Average Nodes In Shell	3.00
Average Hubs In Shell	0.00
Average Links In Shell	2.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AXF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:F239	S:S:V258	5.24	1	Yes	Yes	6	4	2	1
S:S:E241	S:S:H254	7.39	1	No	No	5	3	2	2
S:S:E241	S:S:V258	7.13	1	No	Yes	5	4	2	1
S:S:H254	S:S:V258	5.54	1	No	Yes	3	4	2	1
H:H:?13	S:S:N261	28.17	0	No	No	0	4	0	1
H:H:?13	S:S:V258	1.33	0	No	Yes	0	4	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	14.75
Average Nodes In Shell	6.00
Average Hubs In Shell	2.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AXF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:H312	S:S:V284	4.15	1	Yes	Yes	3	3	1	2
S:S:V284	S:S:V313	6.41	1	Yes	Yes	3	3	2	2
S:S:N287	S:S:T289	4.39	1	No	No	6	5	1	1
S:S:H312	S:S:N287	7.65	1	Yes	No	3	6	1	1
H:H:?14	S:S:N287	26.95	1	No	No	0	6	0	1
S:S:G290	S:S:T289	1.82	0	No	No	4	5	2	1
H:H:?14	S:S:T289	5.26	1	No	No	0	5	0	1
S:S:H312	S:S:V313	5.54	1	Yes	Yes	3	3	1	2
H:H:?14	S:S:H312	5.73	1	No	Yes	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	12.65
Average Nodes In Shell	7.00
Average Hubs In Shell	3.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AXF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N468	S:S:Q476	7.92	19	No	No	6	3	1	1
S:S:N468	S:S:T478	5.85	19	No	No	6	3	1	2
H:H:?15	S:S:N468	25.72	19	No	No	0	6	0	1
S:S:Q476	S:S:T470	7.09	19	No	No	3	5	1	2
H:H:?15	S:S:Q476	11.87	19	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	18.79
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AXF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N592	S:S:N594	5.45	0	No	Yes	7	3	2	1
S:S:E593	S:S:N594	9.2	23	No	Yes	2	3	1	1
H:H:?16	S:S:E593	14.18	23	No	No	0	2	0	1
S:S:N594	S:S:T596	10.24	23	Yes	No	3	5	1	2
H:H:?16	S:S:N594	29.4	23	No	Yes	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	21.79
Average Nodes In Shell	5.00
Average Hubs In Shell	1.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	4.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

9AYF

Ion

Calcium-sensing

CaS

Homo Sapiens

Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4

Gi1/Beta1/Gamma2

3.6

2024-04-17

10.1038/s41586-024-07331-1

A 2D representation of the interactions of NAG in 9AYF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:V486	S:S:V513	3.21	1	No	Yes	3	3	2	2
S:S:V486	S:S:Y514	3.79	1	No	Yes	3	4	2	1
S:S:N488	S:S:N512	5.45	1	No	Yes	4	4	1	1
S:S:N488	S:S:Y514	4.65	1	No	Yes	4	4	1	1
H:H:?1	S:S:N488	29.4	1	Yes	No	0	4	0	1
S:S:N512	S:S:Y510	2.33	1	Yes	No	4	3	1	1
S:S:F522	S:S:Y510	21.66	0	No	No	1	3	2	1
H:H:?1	S:S:Y510	8.37	1	Yes	No	0	3	0	1
S:S:N512	S:S:Y514	5.81	1	Yes	Yes	4	4	1	1
S:S:A515	S:S:N512	3.13	0	No	Yes	4	4	2	1
H:H:?1	S:S:N512	18.37	1	Yes	Yes	0	4	0	1
H:H:?2	S:S:N512	3.67	1	No	Yes	0	4	1	1
S:S:V513	S:S:Y514	7.57	1	Yes	Yes	3	4	2	1
H:H:?1	S:S:Y514	13.59	1	Yes	Yes	0	4	0	1
H:H:?1	H:H:?2	39.65	1	Yes	No	0	0	0	1
H:H:?1	S:S:K323	1.26	1	Yes	No	0	5	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	18.44
Average Nodes In Shell	11.00
Average Hubs In Shell	4.00
Average Links In Shell	16.00
Average Links Mediated by Hubs In Shell	15.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AYF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N488	S:S:N512	5.45	1	No	Yes	4	4	2	1
S:S:N488	S:S:Y514	4.65	1	No	Yes	4	4	2	2
H:H:?1	S:S:N488	29.4	1	Yes	No	0	4	1	2
S:S:N512	S:S:Y510	2.33	1	Yes	No	4	3	1	2
H:H:?1	S:S:Y510	8.37	1	Yes	No	0	3	1	2
S:S:N512	S:S:Y514	5.81	1	Yes	Yes	4	4	1	2
S:S:A515	S:S:N512	3.13	0	No	Yes	4	4	2	1
H:H:?1	S:S:N512	18.37	1	Yes	Yes	0	4	1	1
H:H:?2	S:S:N512	3.67	1	No	Yes	0	4	0	1
H:H:?1	S:S:Y514	13.59	1	Yes	Yes	0	4	1	2
H:H:?1	H:H:?2	39.65	1	Yes	No	0	0	1	0
H:H:?1	S:S:K323	1.26	1	Yes	No	0	5	1	2

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	21.66
Average Nodes In Shell	8.00
Average Hubs In Shell	3.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AYF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	S:S:R205	3.25	10	Yes	No	0	4	0	1
H:H:?4	S:S:R205	18.42	10	No	No	0	4	1	1
S:S:N207	S:S:N541	13.62	10	No	No	6	5	1	1
S:S:C561	S:S:N207	7.87	0	No	No	9	6	2	1
H:H:?3	S:S:N207	7.35	10	Yes	No	0	6	0	1
S:S:F539	S:S:N541	9.67	10	No	No	1	5	1	1
S:S:F539	S:S:R544	25.66	10	No	No	1	5	1	2
H:H:?3	S:S:F539	8.69	10	Yes	No	0	1	0	1
H:H:?3	S:S:N541	24.5	10	Yes	No	0	5	0	1
S:S:D545	S:S:L547	5.43	0	No	No	5	1	1	2
H:H:?3	S:S:D545	2.42	10	Yes	No	0	5	0	1
H:H:?3	H:H:?4	37.44	10	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.94
Average Nodes In Shell	10.00
Average Hubs In Shell	1.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AYF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?3	S:S:R205	3.25	10	Yes	No	0	4	1	1
H:H:?4	S:S:R205	18.42	10	No	No	0	4	0	1
S:S:N207	S:S:N541	13.62	10	No	No	6	5	2	2
H:H:?3	S:S:N207	7.35	10	Yes	No	0	6	1	2
S:S:F539	S:S:N541	9.67	10	No	No	1	5	2	2
H:H:?3	S:S:F539	8.69	10	Yes	No	0	1	1	2
H:H:?3	S:S:N541	24.5	10	Yes	No	0	5	1	2
H:H:?3	S:S:D545	2.42	10	Yes	No	0	5	1	2
H:H:?3	H:H:?4	37.44	10	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	27.93
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AYF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V486	R:R:Y514	5.05	0	No	Yes	3	4	2	1
R:R:N488	R:R:N512	6.81	1	No	Yes	4	4	1	1
R:R:N488	R:R:Y514	4.65	1	No	Yes	4	4	1	1
H:H:?5	R:R:N488	28.17	1	Yes	No	0	4	0	1
R:R:N512	R:R:Y510	2.33	1	Yes	No	4	3	1	1
R:R:F522	R:R:Y510	19.6	0	No	No	1	3	2	1
H:H:?5	R:R:Y510	7.32	1	Yes	No	0	3	0	1
R:R:N512	R:R:Y514	5.81	1	Yes	Yes	4	4	1	1
R:R:A515	R:R:N512	3.13	0	No	Yes	4	4	2	1
H:H:?5	R:R:N512	17.15	1	Yes	Yes	0	4	0	1
R:R:V513	R:R:Y514	5.05	1	Yes	Yes	3	4	2	1
H:H:?5	R:R:Y514	16.73	1	Yes	Yes	0	4	0	1
H:H:?5	H:H:?6	41.85	1	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	5.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	22.24
Average Nodes In Shell	10.00
Average Hubs In Shell	4.00
Average Links In Shell	13.00
Average Links Mediated by Hubs In Shell	12.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AYF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N488	R:R:N512	6.81	1	No	Yes	4	4	2	2
R:R:N488	R:R:Y514	4.65	1	No	Yes	4	4	2	2
H:H:?5	R:R:N488	28.17	1	Yes	No	0	4	1	2
R:R:N512	R:R:Y510	2.33	1	Yes	No	4	3	2	2
H:H:?5	R:R:Y510	7.32	1	Yes	No	0	3	1	2
R:R:N512	R:R:Y514	5.81	1	Yes	Yes	4	4	2	2
H:H:?5	R:R:N512	17.15	1	Yes	Yes	0	4	1	2
H:H:?5	R:R:Y514	16.73	1	Yes	Yes	0	4	1	2
H:H:?5	H:H:?6	41.85	1	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	1.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	41.85
Average Nodes In Shell	6.00
Average Hubs In Shell	3.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AYF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?7	R:R:R205	3.25	1	Yes	No	0	4	0	1
H:H:?8	R:R:R205	2.17	1	No	No	0	4	1	1
R:R:N207	R:R:N541	16.35	1	No	No	6	5	1	1
R:R:C561	R:R:N207	7.87	1	No	No	9	6	2	1
H:H:?7	R:R:N207	13.47	1	Yes	No	0	6	0	1
R:R:F539	R:R:N541	7.25	1	No	No	1	5	1	1
R:R:F539	R:R:R544	22.45	1	No	No	1	5	1	2
H:H:?7	R:R:F539	6.52	1	Yes	No	0	1	0	1
H:H:?7	R:R:N541	30.62	1	Yes	No	0	5	0	1
R:R:D545	R:R:D578	9.31	0	No	No	5	7	1	2
H:H:?7	R:R:D545	12.11	1	Yes	No	0	5	0	1
H:H:?7	H:H:?8	38.55	1	Yes	No	0	0	0	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	17.42
Average Nodes In Shell	10.00
Average Hubs In Shell	1.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AYF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
H:H:?7	R:R:R205	3.25	1	Yes	No	0	4	1	1
H:H:?8	R:R:R205	2.17	1	No	No	0	4	0	1
R:R:N207	R:R:N541	16.35	1	No	No	6	5	2	2
H:H:?7	R:R:N207	13.47	1	Yes	No	0	6	1	2
R:R:F539	R:R:N541	7.25	1	No	No	1	5	2	2
H:H:?7	R:R:F539	6.52	1	Yes	No	0	1	1	2
H:H:?7	R:R:N541	30.62	1	Yes	No	0	5	1	2
H:H:?7	R:R:D545	12.11	1	Yes	No	0	5	1	2
H:H:?7	H:H:?8	38.55	1	Yes	No	0	0	1	0

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	20.36
Average Nodes In Shell	7.00
Average Hubs In Shell	1.00
Average Links In Shell	9.00
Average Links Mediated by Hubs In Shell	6.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AYF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:E241	S:S:H254	7.39	1	No	No	5	3	2	1
S:S:E241	S:S:V258	8.56	1	No	No	5	4	2	2
S:S:E257	S:S:Q253	2.55	0	No	No	3	3	1	2
S:S:H254	S:S:V258	6.92	1	No	No	3	4	1	2
H:H:?9	S:S:H254	4.59	0	No	No	0	3	0	1
H:H:?9	S:S:E257	11.82	0	No	No	0	3	0	1
H:H:?9	S:S:N261	23.27	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	13.23
Average Nodes In Shell	7.00
Average Hubs In Shell	0.00
Average Links In Shell	7.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AYF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:H312	S:S:V284	2.77	1	Yes	Yes	3	3	1	2
S:S:V284	S:S:V313	6.41	1	Yes	Yes	3	3	2	2
S:S:H312	S:S:N287	8.93	1	Yes	No	3	6	1	1
H:H:?10	S:S:N287	30.62	1	No	No	0	6	0	1
S:S:H312	S:S:V313	6.92	1	Yes	Yes	3	3	1	2
H:H:?10	S:S:H312	13.76	1	No	Yes	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	22.19
Average Nodes In Shell	5.00
Average Hubs In Shell	3.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AYF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N468	S:S:Q476	5.28	22	No	No	6	3	1	1
S:S:N468	S:S:T478	7.31	22	No	No	6	3	1	2
H:H:?11	S:S:N468	29.4	22	No	No	0	6	0	1
S:S:Q476	S:S:T470	8.5	22	No	No	3	5	1	2
H:H:?11	S:S:Q476	11.87	22	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	20.63
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	5.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AYF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E241	R:R:H254	7.39	1	No	No	5	3	2	1
R:R:E241	R:R:V258	9.98	1	No	No	5	4	2	2
R:R:H254	R:R:V258	5.54	1	No	No	3	4	1	2
H:H:?12	R:R:H254	2.29	0	No	No	0	3	0	1
H:H:?12	R:R:E257	7.09	0	No	No	0	3	0	1
H:H:?12	R:R:N261	28.17	0	No	No	0	4	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	12.52
Average Nodes In Shell	6.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AYF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H312	R:R:V284	4.15	1	Yes	No	3	3	1	2
R:R:V284	R:R:V313	4.81	1	No	Yes	3	3	2	2
R:R:H312	R:R:N287	7.65	1	Yes	No	3	6	1	1
H:H:?13	R:R:N287	29.4	1	No	No	0	6	0	1
R:R:H312	R:R:V313	5.54	1	Yes	Yes	3	3	1	2
H:H:?13	R:R:H312	2.29	1	No	Yes	0	3	0	1

Statistics	Value
Average Number Of Links	2.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	15.84
Average Nodes In Shell	5.00
Average Hubs In Shell	2.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	5.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NAG in 9AYF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N468	R:R:Q476	10.56	17	No	No	6	3	1	1
R:R:N468	R:R:T478	5.85	17	No	No	6	3	1	1
H:H:?14	R:R:N468	20.82	17	No	No	0	6	0	1
R:R:Q476	R:R:T470	4.25	17	No	No	3	5	1	2
H:H:?14	R:R:Q476	13.06	17	No	No	0	3	0	1
H:H:?14	R:R:T478	3.94	17	No	No	0	3	0	1

Statistics	Value
Average Number Of Links	3.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	12.61
Average Nodes In Shell	5.00
Average Hubs In Shell	0.00
Average Links In Shell	6.00
Average Links Mediated by Hubs In Shell	0.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	2.89
Average Number Of Links With An Hub	0.72
Average Interaction Strength	21.66
Average Nodes In Shell	6.92
Average Hubs In Shell	1.71
Average Links In Shell	7.90
Average Links Mediated by Hubs In Shell	5.11

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)