psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	S:S:R25	S:S:Y20	11.32	Yes	No	0	4	2
2	S:S:G21	S:S:P22	4.06	No	No	2	3	5
3	S:S:E109	S:S:G21	4.91	No	No	2	5	3
4	S:S:F98	S:S:P22	8.67	Yes	No	2	4	5
5	S:S:E109	S:S:P22	3.14	No	No	2	5	5
6	S:S:D23	S:S:Q24	2.61	No	No	0	1	5
7	S:S:F347	S:S:Q24	10.54	Yes	No	0	5	5
8	S:S:E350	S:S:Q24	5.1	Yes	No	0	5	5
9	S:S:Q27	S:S:R25	5.84	No	Yes	2	4	4
10	S:S:R25	S:S:R96	2.13	Yes	Yes	2	4	4
11	S:S:F98	S:S:R25	17.1	Yes	Yes	2	4	4
12	S:S:A26	S:S:N345	4.69	No	Yes	0	6	8
13	S:S:Q27	S:S:R96	10.51	No	Yes	2	4	4
14	S:S:K28	S:S:Y95	16.72	No	Yes	2	5	8
15	S:S:H344	S:S:K28	7.86	No	No	2	3	5
16	S:S:G30	S:S:T92	1.82	No	No	0	9	7
17	S:S:G30	S:S:G94	2.11	No	No	0	9	9
18	S:S:D31	S:S:L91	9.5	No	Yes	0	8	6
19	S:S:D31	S:S:T92	7.23	No	No	0	8	7
20	S:S:I32	S:S:L91	7.14	Yes	Yes	0	6	6
21	S:S:I32	S:S:L93	2.85	Yes	Yes	0	6	9
22	S:S:I139	S:S:I32	5.89	Yes	Yes	11	5	6
23	S:S:I32	S:S:L431	7.14	Yes	No	11	6	8
24	S:S:I32	S:S:V455	3.07	Yes	Yes	11	6	4
25	S:S:L34	S:S:M74	2.83	Yes	Yes	2	7	8
26	S:S:I78	S:S:L34	2.85	Yes	Yes	2	6	7
27	S:S:L34	S:S:L93	4.15	Yes	Yes	0	7	9
28	S:S:L34	S:S:V424	2.98	Yes	No	2	7	8
29	S:S:I427	S:S:L34	5.71	Yes	Yes	0	5	7
30	S:S:G35	S:S:G36	2.11	Yes	Yes	2	8	7
31	S:S:F114	S:S:G35	3.01	Yes	Yes	2	5	8
32	S:S:G35	S:S:T138	1.82	Yes	No	0	8	6
33	S:S:G35	S:S:V141	5.52	Yes	No	2	8	7
34	S:S:G36	S:S:M74	3.49	Yes	Yes	2	7	8
35	S:S:G36	S:S:I97	3.53	Yes	Yes	2	7	8
36	S:S:G36	S:S:V142	1.84	Yes	No	2	7	7
37	S:S:L37	S:S:T100	4.42	No	No	0	6	7
38	S:S:F114	S:S:L37	3.65	Yes	No	0	5	6
39	S:S:L37	S:S:V153	2.98	No	Yes	0	6	6
40	S:S:F38	S:S:W70	3.01	Yes	Yes	2	7	5
41	S:S:F38	S:S:L71	7.31	Yes	Yes	2	7	4
42	S:S:F38	S:S:M74	6.22	Yes	Yes	2	7	8
43	S:S:F38	S:S:I97	3.77	Yes	Yes	2	7	8
44	S:S:F38	S:S:Y167	12.38	Yes	Yes	2	7	8
45	S:S:F38	S:S:V420	3.93	Yes	Yes	2	7	7
46	S:S:G67	S:S:P39	2.03	No	Yes	2	4	6
47	S:S:P39	S:S:W70	5.4	Yes	Yes	2	6	5
48	S:S:N102	S:S:P39	4.89	No	Yes	0	3	6
49	S:S:P39	S:S:T145	8.74	Yes	Yes	2	6	5
50	S:S:H41	S:S:I40	5.3	Yes	Yes	2	7	5
51	S:S:I40	S:S:Y63	4.84	Yes	Yes	2	5	5
52	S:S:F68	S:S:I40	2.51	Yes	Yes	2	7	5
53	S:S:I40	S:S:L71	2.85	Yes	Yes	2	5	4
54	S:S:D99	S:S:I40	12.59	Yes	Yes	2	9	5
55	S:S:C60	S:S:H41	7.37	Yes	Yes	2	7	7
56	S:S:H41	S:S:Y63	5.44	Yes	Yes	2	7	5
57	S:S:D99	S:S:H41	6.3	Yes	Yes	2	9	7
58	S:S:C101	S:S:H41	5.9	Yes	Yes	2	8	7
59	S:S:E350	S:S:H41	8.62	Yes	Yes	2	5	7
60	S:S:F42	S:S:R62	7.48	Yes	No	0	3	4
61	S:S:F42	S:S:N64	14.5	Yes	No	0	3	4
62	S:S:F42	S:S:P274	8.67	Yes	Yes	8	3	3
63	S:S:F42	S:S:L304	14.61	Yes	No	8	3	2
64	S:S:V44	S:S:V58	8.02	No	No	0	2	1
65	S:S:C60	S:S:V44	3.42	Yes	No	0	7	2
66	S:S:T103	S:S:V44	4.76	No	No	0	4	2
67	S:S:A45	S:S:I61	3.25	No	No	0	1	2
68	S:S:E56	S:S:K47	10.8	No	No	0	1	2
69	R:R:R465	S:S:D48	8.34	Yes	No	0	5	2
70	R:R:K462	S:S:Q49	4.07	Yes	No	35	4	1
71	R:R:H466	S:S:Q49	2.47	Yes	No	35	4	1
72	R:R:W458	S:S:D50	3.35	Yes	Yes	0	4	3
73	R:R:K462	S:S:D50	11.06	Yes	Yes	0	4	3
74	R:R:R465	S:S:D50	4.76	Yes	Yes	0	5	3
75	R:R:K462	S:S:L51	4.23	Yes	No	0	4	6
76	R:R:F444	S:S:K52	21.09	Yes	Yes	17	3	3
77	R:R:T445	S:S:K52	9.01	No	Yes	0	1	3
78	R:R:S448	S:S:K52	4.59	No	Yes	17	3	3
79	R:R:Q459	S:S:K52	4.07	Yes	Yes	17	7	3
80	S:S:P55	S:S:R54	2.88	Yes	No	17	6	2
81	R:R:E456	S:S:R54	11.63	No	No	17	5	2
82	R:R:W458	S:S:R54	5	Yes	No	17	4	2
83	R:R:Y161	S:S:P55	16.69	No	Yes	0	4	6
84	R:R:W458	S:S:P55	12.16	Yes	Yes	17	4	6
85	S:S:C101	S:S:C60	7.28	Yes	Yes	2	8	7
86	S:S:C60	S:S:K106	3.23	Yes	Yes	2	7	4
87	S:S:Q245	S:S:R62	2.34	Yes	No	0	4	4
88	S:S:F65	S:S:Y63	8.25	Yes	Yes	2	2	5
89	S:S:F68	S:S:Y63	4.13	Yes	Yes	2	7	5
90	S:S:E350	S:S:Y63	7.86	Yes	Yes	2	5	5
91	S:S:F351	S:S:Y63	5.16	Yes	Yes	2	6	5
92	S:S:E354	S:S:Y63	16.83	No	Yes	2	4	5
93	S:S:N64	S:S:R66	6.03	No	Yes	0	4	5
94	S:S:G67	S:S:N64	3.39	No	No	0	4	4
95	S:S:F351	S:S:F65	4.29	Yes	Yes	2	6	2
96	S:S:E354	S:S:F65	2.33	No	Yes	2	4	2
97	S:S:F65	S:S:T406	15.56	Yes	No	2	2	4
98	S:S:F65	S:S:P407	7.22	Yes	Yes	2	2	1
99	S:S:F65	S:S:Y408	3.09	Yes	Yes	2	2	3
100	S:S:R66	S:S:R69	3.2	Yes	Yes	2	5	8
101	S:S:R66	S:S:W70	8	Yes	Yes	2	5	5
102	S:S:P407	S:S:R66	2.88	Yes	Yes	2	1	5
103	S:S:R66	X:X:W1	3	Yes	Yes	2	5	0
104	S:S:R66	X:X:?2	18.17	Yes	Yes	2	5	0
105	S:S:G67	S:S:W70	5.63	No	Yes	2	4	5
106	S:S:F68	S:S:Q72	12.88	Yes	Yes	2	7	7
107	S:S:F68	S:S:N345	4.83	Yes	Yes	2	7	8
108	S:S:F347	S:S:F68	3.22	Yes	Yes	0	5	7
109	S:S:F351	S:S:F68	10.72	Yes	Yes	2	6	7
110	S:S:F68	S:S:Y408	11.35	Yes	Yes	2	7	3
111	S:S:R69	S:S:Y408	3.09	Yes	Yes	2	8	3
112	S:S:R69	S:S:Y411	17.49	Yes	Yes	0	8	5
113	S:S:R69	X:X:?2	5.59	Yes	Yes	2	8	0
114	S:S:T145	S:S:W70	7.28	Yes	Yes	2	5	5
115	S:S:W70	S:S:Y167	5.79	Yes	Yes	2	5	8
116	S:S:I416	S:S:W70	12.92	Yes	Yes	2	4	5
117	S:S:S417	S:S:W70	6.18	No	Yes	2	6	5
118	S:S:V420	S:S:W70	2.45	Yes	Yes	2	7	5
119	S:S:W70	X:X:W1	2.81	Yes	Yes	2	5	0
120	S:S:W70	X:X:?2	9.17	Yes	Yes	2	5	0
121	S:S:I75	S:S:L71	2.85	Yes	Yes	2	4	4
122	S:S:I97	S:S:L71	5.71	Yes	Yes	2	8	4
123	S:S:F347	S:S:L71	2.44	Yes	Yes	0	5	4
124	S:S:F333	S:S:Q72	9.37	Yes	Yes	2	7	7
125	S:S:L334	S:S:Q72	2.66	Yes	Yes	2	6	7
126	S:S:N345	S:S:Q72	6.6	Yes	Yes	2	8	7
127	S:S:Q72	S:S:Y408	6.76	Yes	Yes	2	7	3
128	S:S:A73	S:S:F330	4.16	No	Yes	0	7	8
129	S:S:A73	S:S:V420	3.39	No	Yes	0	7	7
130	S:S:I78	S:S:M74	2.92	Yes	Yes	2	6	8
131	S:S:I97	S:S:M74	7.29	Yes	Yes	2	8	8
132	S:S:M74	S:S:V142	4.56	Yes	No	2	8	7
133	S:S:I75	S:S:Y95	9.67	Yes	Yes	2	4	8
134	S:S:I75	S:S:I97	2.94	Yes	Yes	2	4	8
135	S:S:F333	S:S:I75	6.28	Yes	Yes	2	7	4
136	S:S:E79	S:S:F76	4.66	No	Yes	2	7	7
137	S:S:E80	S:S:F76	8.16	No	Yes	2	8	7
138	S:S:F76	S:S:I327	3.77	Yes	Yes	2	7	6
139	S:S:F330	S:S:F76	5.36	Yes	Yes	2	8	7
140	S:S:F333	S:S:F76	13.93	Yes	Yes	2	7	7
141	S:S:A77	S:S:Y421	4	No	Yes	0	8	8
142	S:S:I78	S:S:Y95	4.84	Yes	Yes	2	6	8
143	S:S:I78	S:S:V424	3.07	Yes	No	2	6	8
144	S:S:E79	S:S:F333	9.33	No	Yes	2	7	7
145	S:S:E80	S:S:Y421	6.73	No	Yes	2	8	8
146	S:S:E80	S:S:Y425	4.49	No	Yes	2	8	8
147	S:S:I81	S:S:L87	5.71	Yes	Yes	2	9	6
148	S:S:I81	S:S:L93	2.85	Yes	Yes	0	9	9
149	S:S:I81	S:S:Y425	6.04	Yes	Yes	2	9	8
150	S:S:A428	S:S:I81	4.87	No	Yes	0	9	9
151	S:S:N82	S:S:T92	5.85	No	No	0	9	7
152	S:S:L93	S:S:N82	5.49	Yes	No	0	9	9
153	S:S:P85	S:S:S84	3.56	No	No	0	3	6
154	S:S:P85	X:X:?3	3.02	No	No	0	3	0
155	S:S:L87	S:S:Y425	4.69	Yes	Yes	2	6	8
156	S:S:H429	S:S:L87	5.14	No	Yes	2	6	6
157	S:S:L87	S:S:Q432	5.32	Yes	No	0	6	7
158	S:S:L88	S:S:L91	5.54	No	Yes	0	9	6
159	S:S:L88	S:S:Q432	2.66	No	No	0	9	7
160	S:S:P89	S:S:Y435	6.95	No	No	0	8	3
161	S:S:P89	X:X:?3	3.02	No	No	0	8	0
162	S:S:I452	S:S:L91	2.85	No	Yes	0	3	6
163	S:S:I97	S:S:Y95	7.25	Yes	Yes	2	8	8
164	S:S:H344	S:S:Y95	3.27	No	Yes	2	3	8
165	S:S:F98	S:S:R96	4.28	Yes	Yes	2	4	4
166	S:S:F114	S:S:R96	5.34	Yes	Yes	2	5	4
167	S:S:P136	S:S:R96	7.21	No	Yes	0	4	4
168	S:S:A110	S:S:F98	4.16	No	Yes	0	5	4
169	S:S:F98	S:S:S113	6.61	Yes	No	0	4	4
170	S:S:F114	S:S:F98	6.43	Yes	Yes	2	5	4
171	S:S:C101	S:S:D99	6.22	Yes	Yes	2	8	9
172	S:S:D99	S:S:F347	4.78	Yes	Yes	0	9	5
173	S:S:C101	S:S:K106	4.85	Yes	Yes	2	8	4
174	S:S:K106	S:S:T103	3	Yes	No	0	4	4
175	R:R:N155	S:S:V104	8.87	Yes	No	1	5	4
176	R:R:Q179	S:S:V104	5.73	Yes	No	1	5	4
177	S:S:K106	S:S:S105	3.06	Yes	No	0	4	4
178	R:R:L159	S:S:L108	2.77	No	No	0	5	4
179	R:R:L123	S:S:E109	3.98	No	No	0	5	5
180	S:S:T111	S:S:V153	7.93	No	Yes	2	7	6
181	S:S:L156	S:S:T111	5.9	No	No	0	5	7
182	S:S:L157	S:S:T111	2.95	Yes	No	2	7	7
183	S:S:L112	S:S:L156	2.77	No	No	0	5	5
184	R:R:K119	S:S:L112	11.28	Yes	No	0	3	5
185	R:R:L156	S:S:L112	4.15	No	No	0	5	5
186	S:S:F114	S:S:V141	6.55	Yes	No	2	5	7
187	S:S:F160	S:S:V115	10.49	Yes	No	0	7	5
188	S:S:N118	S:S:Q117	2.64	No	No	0	4	6
189	S:S:I135	S:S:Q117	10.98	Yes	No	0	4	6
190	S:S:F160	S:S:N118	7.25	Yes	No	2	7	4
191	S:S:I162	S:S:N118	4.25	Yes	No	2	6	4
192	S:S:K119	S:S:L123	2.82	Yes	Yes	1	3	5
193	S:S:K119	S:S:L125	4.23	Yes	Yes	1	3	4
194	R:R:L112	S:S:K119	2.82	Yes	Yes	1	5	3
195	R:R:K119	S:S:K119	10.06	Yes	Yes	1	3	3
196	S:S:C131	S:S:I120	3.27	No	No	0	3	3
197	R:R:E109	S:S:S122	2.87	Yes	No	0	5	3
198	S:S:L123	S:S:L125	8.3	Yes	Yes	1	5	4
199	R:R:Y20	S:S:L123	2.34	Yes	Yes	1	2	5
200	R:R:G21	S:S:L123	3.42	No	Yes	1	3	5
201	R:R:E109	S:S:L123	6.63	Yes	Yes	1	5	5
202	R:R:Y20	S:S:L125	2.34	Yes	Yes	1	2	4
203	R:R:A116	S:S:L125	3.15	No	Yes	0	6	4
204	S:S:H134	S:S:S132	2.79	No	No	0	4	4
205	S:S:I135	S:S:S132	3.1	Yes	No	36	4	4
206	R:R:L125	S:S:S132	3	Yes	No	36	4	4
207	S:S:E133	S:S:H134	2.46	No	No	0	5	4
208	S:S:I135	S:S:P136	3.39	Yes	No	0	4	4
209	R:R:L125	S:S:I135	7.14	Yes	Yes	36	4	4
210	S:S:I139	S:S:L431	4.28	Yes	No	11	5	8
211	S:S:I139	S:S:V460	3.07	Yes	No	0	5	7
212	S:S:A140	S:S:P163	1.87	No	Yes	0	6	8
213	S:S:A140	S:S:I427	4.87	No	Yes	0	6	5
214	S:S:L157	S:S:V141	4.47	Yes	No	2	7	7
215	S:S:V142	S:S:Y167	2.52	No	Yes	2	7	8
216	S:S:G143	S:S:Q164	4.93	No	Yes	0	9	8
217	S:S:G143	S:S:S166	1.86	No	Yes	0	9	9
218	S:S:A144	S:S:V149	3.39	No	No	0	6	4
219	S:S:G146	S:S:T145	3.64	No	Yes	2	5	5
220	S:S:T145	S:S:Y167	6.24	Yes	Yes	2	5	8
221	S:S:A168	S:S:T145	5.03	No	Yes	2	5	5
222	S:S:T145	X:X:W1	4.85	Yes	Yes	2	5	0
223	S:S:G146	S:S:V149	3.68	No	No	0	5	4
224	S:S:G146	X:X:W1	4.22	No	Yes	2	5	0
225	S:S:S147	S:S:S171	6.52	No	No	0	8	7
226	S:S:S147	S:S:Y218	2.54	No	Yes	2	8	7
227	S:S:S147	X:X:W1	6.18	No	Yes	2	8	0
228	S:S:G148	S:S:T151	3.64	No	Yes	2	4	5
229	S:S:D217	S:S:G148	3.35	Yes	No	2	6	4
230	S:S:Q164	S:S:S150	2.89	Yes	Yes	2	8	8
231	S:S:S150	S:S:S166	3.26	Yes	Yes	2	8	9
232	S:S:S150	S:S:S169	6.52	Yes	Yes	2	8	8
233	S:S:F183	S:S:S150	5.28	Yes	Yes	2	8	8
234	S:S:L174	S:S:T151	5.9	Yes	Yes	2	7	5
235	S:S:F180	S:S:T151	5.19	Yes	Yes	2	5	5
236	S:S:D217	S:S:T151	4.34	Yes	Yes	2	6	5
237	R:R:N155	S:S:A152	3.13	Yes	No	0	5	5
238	S:S:L157	S:S:V153	2.98	Yes	Yes	2	7	6
239	S:S:Q164	S:S:V153	7.16	Yes	Yes	2	8	6
240	S:S:A154	S:S:Q164	3.03	No	Yes	2	7	8
241	S:S:A154	S:S:F180	2.77	No	Yes	2	7	5
242	S:S:A154	S:S:F183	2.77	No	Yes	2	7	8
243	S:S:N155	S:S:Q179	6.6	Yes	Yes	2	5	5
244	S:S:F180	S:S:N155	6.04	Yes	Yes	2	5	5
245	R:R:V104	S:S:N155	5.91	No	Yes	2	4	5
246	R:R:A152	S:S:N155	3.13	No	Yes	2	5	5
247	R:R:L112	S:S:L156	4.15	Yes	No	0	5	5
248	S:S:I162	S:S:L157	4.28	Yes	Yes	2	6	7
249	S:S:L157	S:S:Q164	7.99	Yes	Yes	2	7	8
250	S:S:G158	S:S:S182	3.71	No	No	0	6	7
251	S:S:F160	S:S:L159	3.65	Yes	No	0	7	5
252	R:R:L108	S:S:L159	4.15	No	No	0	4	5
253	S:S:F160	S:S:I162	2.51	Yes	Yes	2	7	6
254	S:S:K181	S:S:Y161	7.17	No	No	0	7	4
255	S:S:L461	S:S:Y161	2.34	Yes	No	0	7	4
256	R:R:P55	S:S:Y161	9.74	Yes	No	0	6	4
257	S:S:I162	S:S:P163	3.39	Yes	Yes	0	6	8
258	S:S:A457	S:S:P163	1.87	No	Yes	0	4	8
259	S:S:P163	S:S:V460	3.53	Yes	No	0	8	7
260	S:S:L461	S:S:P163	6.57	Yes	Yes	0	7	8
261	S:S:L464	S:S:P163	3.28	Yes	Yes	0	7	8
262	S:S:F183	S:S:Q164	10.54	Yes	Yes	2	8	8
263	S:S:L184	S:S:V165	2.98	No	Yes	2	6	6
264	S:S:T186	S:S:V165	3.17	No	Yes	2	8	6
265	S:S:A423	S:S:V165	3.39	No	Yes	2	9	6
266	S:S:S426	S:S:V165	3.23	Yes	Yes	2	7	6
267	S:S:I427	S:S:V165	3.07	Yes	Yes	0	5	6
268	S:S:F479	S:S:V165	2.62	Yes	Yes	2	8	6
269	S:S:S166	S:S:S169	6.52	Yes	Yes	2	9	8
270	S:S:F183	S:S:S166	3.96	Yes	Yes	2	8	9
271	S:S:A168	S:S:Y167	2.67	No	Yes	2	5	8
272	S:S:I416	S:S:Y167	4.84	Yes	Yes	2	4	8
273	S:S:V420	S:S:Y167	10.09	Yes	Yes	2	7	8
274	S:S:A168	X:X:W1	3.89	No	Yes	2	5	0
275	S:S:L174	S:S:S169	3	Yes	Yes	2	7	8
276	S:S:F183	S:S:S169	2.64	Yes	Yes	2	8	8
277	S:S:I187	S:S:S170	4.64	Yes	Yes	2	6	7
278	S:S:D190	S:S:S170	10.31	Yes	Yes	2	8	7
279	S:S:S170	S:S:Y218	2.54	Yes	Yes	2	7	7
280	S:S:S170	X:X:W1	4.94	Yes	Yes	2	7	0
281	S:S:L174	S:S:S171	4.5	Yes	No	0	7	7
282	S:S:L173	S:S:R172	6.07	Yes	Yes	2	5	4
283	S:S:E191	S:S:R172	9.3	No	Yes	0	3	4
284	S:S:P221	S:S:R172	2.88	No	Yes	2	3	4
285	R:R:D215	S:S:R172	10.72	Yes	Yes	2	6	4
286	R:R:R220	S:S:R172	2.13	Yes	Yes	2	6	4
287	R:R:L242	S:S:R172	2.43	No	Yes	2	4	4
288	S:S:D217	S:S:L173	4.07	Yes	Yes	2	6	5
289	S:S:L173	S:S:P221	6.57	Yes	No	2	5	3
290	R:R:R220	S:S:L173	10.93	Yes	Yes	2	6	5
291	S:S:F180	S:S:L174	7.31	Yes	Yes	2	5	7
292	S:S:F183	S:S:L174	13.4	Yes	Yes	2	8	7
293	S:S:L174	S:S:R185	4.86	Yes	Yes	2	7	9
294	S:S:R185	S:S:S175	5.27	Yes	Yes	2	9	8
295	S:S:N189	S:S:S175	2.98	No	Yes	2	8	8
296	S:S:C482	S:S:S175	6.89	No	Yes	2	7	8
297	S:S:D484	S:S:S175	4.42	Yes	Yes	2	8	8
298	S:S:N176	S:S:N178	8.17	No	No	0	6	3
299	S:S:N176	S:S:Q179	2.64	No	Yes	0	6	5
300	S:S:F183	S:S:K177	3.72	Yes	No	0	8	7
301	R:R:Y246	S:S:N178	18.61	No	No	0	3	3
302	S:S:F180	S:S:Q179	9.37	Yes	Yes	2	5	5
303	R:R:V104	S:S:Q179	7.16	No	Yes	2	4	5
304	S:S:L461	S:S:S182	3	Yes	No	0	7	7
305	S:S:F183	S:S:R185	6.41	Yes	Yes	2	8	9
306	S:S:L184	S:S:L464	4.15	No	Yes	0	6	7
307	S:S:F479	S:S:L184	10.96	Yes	No	2	8	6
308	S:S:N189	S:S:R185	7.23	No	Yes	2	8	9
309	S:S:D484	S:S:R185	7.15	Yes	Yes	2	8	9
310	S:S:N419	S:S:T186	2.92	No	No	0	7	8
311	S:S:A423	S:S:T186	3.36	No	No	2	9	8
312	S:S:I187	S:S:P188	5.08	Yes	Yes	2	6	8
313	S:S:E297	S:S:I187	4.1	Yes	Yes	2	8	6
314	S:S:I187	S:S:L322	7.14	Yes	Yes	2	6	4
315	S:S:I187	S:S:N419	4.25	Yes	No	0	6	7
316	S:S:L322	S:S:P188	3.28	Yes	Yes	2	4	8
317	S:S:G487	S:S:P188	2.03	No	Yes	0	6	8
318	S:S:P188	S:S:Y489	5.56	Yes	Yes	2	8	8
319	S:S:E191	S:S:N189	7.89	No	No	0	3	8
320	S:S:D190	S:S:Q193	13.05	Yes	Yes	2	8	9
321	S:S:D190	S:S:Y218	5.75	Yes	Yes	2	8	7
322	S:S:D190	S:S:E297	3.9	Yes	Yes	2	8	8
323	S:S:E191	S:S:K225	13.5	No	Yes	0	3	3
324	S:S:H192	S:S:Y511	4.36	No	Yes	2	4	5
325	S:S:H192	S:S:V513	11.07	No	Yes	2	4	3
326	S:S:H192	S:S:R520	5.64	No	No	2	4	3
327	S:S:Q193	S:S:S296	4.33	Yes	No	0	9	8
328	S:S:E297	S:S:Q193	12.74	Yes	Yes	2	8	9
329	S:S:F320	S:S:Q193	12.88	Yes	Yes	2	6	9
330	S:S:Q193	S:S:Y489	5.64	Yes	Yes	2	9	8
331	S:S:A194	S:S:K225	3.21	No	Yes	0	7	3
332	S:S:A194	S:S:F270	2.77	No	Yes	0	7	7
333	S:S:D199	S:S:T195	4.34	Yes	Yes	2	7	4
334	S:S:K225	S:S:T195	3	Yes	Yes	2	3	4
335	S:S:E229	S:S:T195	11.29	Yes	Yes	2	5	4
336	S:S:T195	S:S:Y511	2.5	Yes	Yes	2	4	5
337	S:S:A196	S:S:F320	4.16	No	Yes	0	8	6
338	S:S:A196	S:S:Y511	9.34	No	Yes	0	8	5
339	S:S:M197	S:S:V268	3.04	No	Yes	2	7	6
340	S:S:F270	S:S:M197	9.95	Yes	No	2	7	7
341	S:S:F320	S:S:M197	6.22	Yes	No	2	6	7
342	S:S:A198	S:S:F226	2.77	No	Yes	0	7	6
343	S:S:A198	S:S:R233	4.15	No	Yes	0	7	4
344	S:S:D199	S:S:R233	10.72	Yes	Yes	2	7	4
345	S:S:D199	S:S:Y511	5.75	Yes	Yes	2	7	5
346	S:S:D199	S:S:L521	4.07	Yes	Yes	2	7	5
347	S:S:F204	S:S:I200	2.51	Yes	Yes	0	7	8
348	S:S:I200	S:S:L294	2.85	Yes	Yes	0	8	7
349	S:S:F320	S:S:I200	3.77	Yes	Yes	0	6	8
350	S:S:I200	S:S:L521	4.28	Yes	Yes	0	8	5
351	S:S:I201	S:S:W206	4.7	Yes	Yes	2	6	9
352	S:S:I201	S:S:V209	3.07	Yes	Yes	2	6	8
353	S:S:F226	S:S:I201	2.51	Yes	Yes	2	6	6
354	S:S:I201	S:S:I235	5.89	Yes	Yes	2	6	7
355	S:S:I201	S:S:L294	2.85	Yes	Yes	0	6	7
356	S:S:E202	S:S:R205	5.82	No	No	2	5	4
357	S:S:E202	S:S:I235	2.73	No	Yes	2	5	7
358	H:H:?2	S:S:E202	5.91	No	No	2	0	5
359	S:S:F204	S:S:Y203	7.22	Yes	No	2	7	5
360	S:S:L521	S:S:Y203	3.52	Yes	No	2	5	5
361	S:S:I523	S:S:Y203	6.04	No	No	2	6	5
362	S:S:F204	S:S:W206	11.02	Yes	Yes	2	7	9
363	S:S:F204	S:S:I523	5.02	Yes	No	2	7	6
364	S:S:E525	S:S:F204	4.66	Yes	Yes	2	4	7
365	S:S:F204	S:S:W530	10.02	Yes	Yes	2	7	8
366	H:H:?1	S:S:R205	6.5	Yes	No	2	0	4
367	H:H:?2	S:S:R205	5.42	No	No	2	0	4
368	S:S:V266	S:S:W206	13.48	Yes	Yes	2	7	9
369	S:S:W206	S:S:W530	5.62	Yes	Yes	2	9	8
370	S:S:V537	S:S:W206	2.45	Yes	Yes	2	4	9
371	S:S:S540	S:S:W206	7.41	No	Yes	2	9	9
372	S:S:N207	S:S:N541	13.62	No	No	2	6	5
373	S:S:C561	S:S:N207	11.02	Yes	No	2	9	6
374	H:H:?1	S:S:N207	11.02	Yes	No	2	0	6
375	S:S:C236	S:S:W208	2.61	Yes	Yes	2	9	9
376	S:S:D238	S:S:W208	16.75	Yes	Yes	2	8	9
377	S:S:T263	S:S:W208	4.85	No	Yes	0	5	9
378	S:S:A264	S:S:W208	3.89	No	Yes	2	7	9
379	S:S:C542	S:S:W208	14.37	No	Yes	2	9	9
380	S:S:P559	S:S:W208	5.4	Yes	Yes	2	6	9
381	S:S:C561	S:S:W208	2.61	Yes	Yes	2	9	9
382	S:S:C562	S:S:W208	5.22	No	Yes	2	9	9
383	S:S:G210	S:S:V209	1.84	No	Yes	0	8	8
384	S:S:I235	S:S:V209	3.07	Yes	Yes	2	7	8
385	S:S:I237	S:S:V209	3.07	No	Yes	2	6	8
386	S:S:V209	S:S:V266	6.41	Yes	Yes	2	8	7
387	S:S:F239	S:S:G210	7.53	Yes	No	0	6	8
388	S:S:I223	S:S:T211	6.08	Yes	Yes	2	5	5
389	S:S:F226	S:S:T211	2.59	Yes	Yes	2	6	5
390	S:S:I237	S:S:T211	6.08	No	Yes	2	6	5
391	S:S:S240	S:S:T211	7.99	No	Yes	0	4	5
392	S:S:I212	S:S:I243	5.89	Yes	No	2	6	5
393	S:S:I212	S:S:I259	2.94	Yes	No	0	6	6
394	S:S:I212	S:S:I267	2.94	Yes	Yes	2	6	7
395	S:S:I212	S:S:V269	3.07	Yes	No	0	6	5
396	S:S:I212	S:S:L279	2.85	Yes	No	2	6	5
397	S:S:A213	S:S:G219	1.95	No	No	0	4	7
398	S:S:A213	S:S:I223	4.87	No	Yes	0	4	5
399	S:S:A214	S:S:D216	3.09	Yes	No	0	5	6
400	S:S:A214	S:S:G219	1.95	Yes	No	0	5	7
401	S:S:A214	S:S:S271	3.42	Yes	No	0	5	4
402	S:S:A214	S:S:D275	3.09	Yes	Yes	0	5	5
403	S:S:D215	S:S:R220	7.15	No	Yes	2	6	6
404	S:S:D215	S:S:L242	10.86	No	No	2	6	4
405	R:R:R172	S:S:D215	10.72	Yes	No	2	4	6
406	S:S:D216	S:S:Y218	3.45	No	Yes	0	6	7
407	S:S:D217	S:S:R220	3.57	Yes	Yes	2	6	6
408	S:S:G219	S:S:Y218	2.9	No	Yes	0	7	7
409	S:S:S296	S:S:Y218	6.36	No	Yes	0	8	7
410	S:S:A298	S:S:Y218	4	No	Yes	2	6	7
411	S:S:Y218	X:X:W1	15.43	Yes	Yes	2	7	0
412	R:R:R172	S:S:R220	2.13	Yes	Yes	2	4	6
413	R:R:L173	S:S:R220	8.5	Yes	Yes	2	5	6
414	S:S:G222	S:S:P221	2.03	No	No	0	7	3
415	S:S:F270	S:S:G222	4.52	Yes	No	0	7	7
416	S:S:F226	S:S:I223	2.51	Yes	Yes	2	6	5
417	S:S:F270	S:S:I223	8.79	Yes	Yes	2	7	5
418	S:S:E224	S:S:R227	15.12	No	Yes	0	6	4
419	R:R:E224	S:S:E224	3.81	No	No	0	6	6
420	S:S:E228	S:S:K225	9.45	No	Yes	2	3	3
421	S:S:E229	S:S:K225	10.8	Yes	Yes	2	5	3
422	S:S:A230	S:S:F226	4.16	No	Yes	0	6	6
423	S:S:F226	S:S:I237	2.51	Yes	No	2	6	6
424	S:S:F226	S:S:V268	10.49	Yes	Yes	2	6	6
425	S:S:F226	S:S:F270	4.29	Yes	Yes	2	6	7
426	S:S:E231	S:S:R227	5.82	No	Yes	0	4	4
427	R:R:R227	S:S:R227	9.6	Yes	Yes	0	4	4
428	R:R:S240	S:S:R227	2.64	No	Yes	0	4	4
429	S:S:E228	S:S:E229	2.54	No	Yes	2	3	5
430	S:S:E229	S:S:E232	5.07	Yes	No	2	5	4
431	S:S:E229	S:S:R233	9.3	Yes	Yes	2	5	4
432	S:S:A230	S:S:I235	4.87	No	Yes	0	6	7
433	S:S:E232	S:S:R233	3.49	No	Yes	2	4	4
434	S:S:I235	S:S:R233	2.51	Yes	Yes	2	7	4
435	R:R:G557	S:S:D234	5.03	No	No	37	6	5
436	I:I:?1	S:S:D234	7.48	No	No	37	0	5
437	S:S:C236	S:S:P559	1.88	Yes	Yes	2	9	6
438	S:S:C236	S:S:C561	7.28	Yes	Yes	2	9	9
439	S:S:D238	S:S:F239	4.78	Yes	Yes	2	8	6
440	S:S:D238	S:S:S262	4.42	Yes	No	2	8	7
441	S:S:A264	S:S:D238	3.09	No	Yes	2	7	8
442	S:S:F239	S:S:V258	5.24	Yes	No	2	6	4
443	S:S:F239	S:S:I259	2.51	Yes	No	0	6	6
444	S:S:F239	S:S:S262	6.61	Yes	No	2	6	7
445	S:S:F239	S:S:I267	3.77	Yes	Yes	2	6	7
446	S:S:E241	S:S:H254	4.92	No	No	2	5	3
447	S:S:E241	S:S:V255	5.7	No	No	0	5	5
448	S:S:E241	S:S:V258	9.98	No	No	2	5	4
449	R:R:R172	S:S:L242	2.43	Yes	No	2	4	4
450	S:S:I243	S:S:V255	3.07	No	No	0	5	5
451	S:S:I243	S:S:L279	4.28	No	No	2	5	5
452	S:S:D275	S:S:S244	2.94	Yes	No	0	5	4
453	S:S:Q245	S:S:Y246	14.65	Yes	No	0	4	3
454	S:S:P274	S:S:Q245	4.74	Yes	Yes	0	3	4
455	S:S:D275	S:S:Q245	5.22	Yes	Yes	0	5	4
456	R:R:N178	S:S:Y246	15.12	No	No	0	3	3
457	S:S:E251	S:S:S247	10.06	No	No	0	4	2
458	S:S:I252	S:S:S247	6.19	No	No	0	4	2
459	S:S:D248	S:S:E250	9.09	No	No	0	3	2
460	S:S:D248	S:S:E251	9.09	No	No	0	3	4
461	S:S:E249	S:S:E250	7.61	No	No	0	2	2
462	S:S:I252	S:S:P278	3.39	No	No	0	4	2
463	S:S:E282	S:S:I252	5.47	Yes	No	0	6	4
464	S:S:E257	S:S:Q253	2.55	No	No	38	3	3
465	S:S:E282	S:S:Q253	8.92	Yes	No	0	6	3
466	S:S:Q253	S:S:R286	5.84	No	Yes	38	3	4
467	S:S:H254	S:S:V258	4.15	No	No	2	3	4
468	H:H:?5	S:S:H254	2.29	No	No	0	0	3
469	S:S:I259	S:S:V255	3.07	No	No	0	6	5
470	S:S:E282	S:S:V256	2.85	Yes	No	0	6	5
471	S:S:I283	S:S:V256	6.14	Yes	No	0	4	5
472	S:S:R286	S:S:V256	6.54	Yes	No	0	4	5
473	S:S:E257	S:S:R286	3.49	No	Yes	38	3	4
474	H:H:?5	S:S:E257	3.55	No	No	0	0	3
475	S:S:N261	S:S:Q260	2.64	No	No	0	4	5
476	S:S:Q260	S:S:R286	5.84	No	Yes	0	5	4
477	S:S:I288	S:S:Q260	2.74	No	No	0	4	5
478	H:H:?5	S:S:N261	24.5	No	No	0	0	4
479	S:S:F539	S:S:K265	2.48	Yes	No	0	1	5
480	S:S:K265	S:S:S540	3.06	No	No	0	5	9
481	S:S:I292	S:S:V266	3.07	Yes	Yes	2	7	7
482	S:S:L294	S:S:V266	2.98	Yes	Yes	0	7	7
483	S:S:S540	S:S:V266	6.46	No	Yes	2	9	7
484	S:S:I267	S:S:K291	5.82	Yes	No	2	7	6
485	S:S:I267	S:S:W293	9.4	Yes	Yes	2	7	8
486	S:S:F270	S:S:V268	2.62	Yes	Yes	2	7	6
487	S:S:L294	S:S:V268	5.96	Yes	Yes	0	7	6
488	S:S:V269	S:S:W293	2.45	No	Yes	0	5	8
489	S:S:V269	S:S:W299	9.81	No	Yes	0	5	7
490	S:S:L276	S:S:S271	7.51	No	No	0	5	4
491	S:S:G273	S:S:S272	1.86	No	No	8	4	5
492	S:S:P274	S:S:S272	3.56	Yes	No	8	3	5
493	S:S:D275	S:S:S272	4.42	Yes	No	0	5	5
494	S:S:G273	S:S:P274	4.06	No	Yes	8	4	3
495	S:S:G273	S:S:S302	1.86	No	No	0	4	5
496	S:S:L304	S:S:P274	3.28	No	Yes	8	2	3
497	S:S:L276	S:S:W299	10.25	No	Yes	8	5	7
498	S:S:I305	S:S:L276	7.14	Yes	No	8	4	5
499	S:S:E277	S:S:K281	5.4	Yes	No	8	2	2
500	S:S:E277	S:S:L304	7.95	Yes	No	8	2	2
501	S:S:E277	S:S:I305	4.1	Yes	Yes	8	2	4
502	S:S:E277	S:S:Y310	2.24	Yes	Yes	8	2	3
503	S:S:I283	S:S:L279	4.28	Yes	No	0	4	5
504	S:S:I280	S:S:I305	4.42	No	Yes	0	5	4
505	S:S:I280	S:S:Y310	8.46	No	Yes	0	5	3
506	S:S:I280	S:S:V314	6.14	No	No	0	5	7
507	S:S:K281	S:S:Y310	4.78	No	Yes	8	2	3
508	S:S:E282	S:S:R285	8.14	Yes	No	0	6	3
509	S:S:I283	S:S:I288	4.42	Yes	No	0	4	4
510	S:S:I283	S:S:V313	3.07	Yes	No	0	4	3
511	S:S:V284	S:S:Y310	10.09	No	Yes	8	3	3
512	S:S:H312	S:S:V284	2.77	No	No	8	3	3
513	S:S:V284	S:S:V313	6.41	No	No	8	3	3
514	S:S:R285	S:S:R286	4.26	No	Yes	0	3	4
515	S:S:N287	S:S:T289	4.39	No	No	0	6	5
516	S:S:H312	S:S:N287	5.1	No	No	0	3	6
517	H:H:?6	S:S:N287	29.4	No	No	0	0	6
518	S:S:I288	S:S:K291	2.91	No	No	0	4	6
519	S:S:G290	S:S:T289	1.82	No	No	0	4	5
520	S:S:K291	S:S:W293	3.48	No	Yes	2	6	8
521	S:S:I292	S:S:W530	7.05	Yes	Yes	2	7	8
522	S:S:I292	S:S:P538	5.08	Yes	No	2	7	8
523	S:S:V314	S:S:W293	8.58	No	Yes	0	7	8
524	S:S:T317	S:S:W293	6.06	No	Yes	0	7	8
525	S:S:I318	S:S:L294	4.28	No	Yes	0	6	7
526	S:S:A295	S:S:W299	11.67	No	Yes	0	7	7
527	S:S:A295	S:S:G319	1.95	No	No	0	7	8
528	S:S:S296	S:S:W299	2.47	No	Yes	0	8	7
529	S:S:E297	S:S:L322	10.6	Yes	Yes	2	8	4
530	S:S:E297	S:S:Y489	4.49	Yes	Yes	2	8	8
531	S:S:A298	X:X:W1	6.48	No	Yes	2	6	0
532	S:S:I305	S:S:W299	5.87	Yes	Yes	8	4	7
533	S:S:W299	S:S:W494	3.75	Yes	Yes	8	7	7
534	S:S:A300	S:S:G319	1.95	No	No	0	6	8
535	S:S:I305	S:S:S302	4.64	Yes	No	0	4	5
536	S:S:P407	S:S:S303	3.56	Yes	No	0	1	3
537	S:S:I305	S:S:W494	3.52	Yes	Yes	8	4	7
538	S:S:A306	S:S:W494	6.48	No	Yes	8	4	7
539	S:S:A306	S:S:I503	4.87	No	No	8	4	4
540	S:S:A306	S:S:F505	2.77	No	No	8	4	4
541	S:S:M307	S:S:P308	3.35	No	No	0	3	2
542	S:S:M307	S:S:Q309	5.44	No	No	8	3	3
543	S:S:M307	S:S:Y310	4.79	No	Yes	8	3	3
544	S:S:Q309	S:S:Y310	9.02	No	Yes	8	3	3
545	S:S:F311	S:S:G315	7.53	Yes	No	0	3	4
546	S:S:F311	S:S:L496	20.7	Yes	No	0	3	3
547	S:S:F311	S:S:I503	7.54	Yes	No	0	3	4
548	S:S:F311	S:S:G532	3.01	Yes	No	0	3	1
549	S:S:H312	S:S:V313	4.15	No	No	8	3	3
550	S:S:G315	S:S:G316	2.11	No	No	0	4	8
551	S:S:G316	S:S:N493	5.09	No	No	0	8	9
552	S:S:G316	S:S:G532	2.11	No	No	0	8	1
553	S:S:T317	S:S:W494	12.13	No	Yes	0	7	7
554	S:S:I318	S:S:W530	3.52	No	Yes	0	6	8
555	S:S:F320	S:S:Y489	4.13	Yes	Yes	2	6	8
556	S:S:A321	S:S:R415	6.91	Yes	No	0	5	5
557	S:S:A321	S:S:I492	3.25	Yes	No	0	5	5
558	S:S:L322	S:S:Y489	3.52	Yes	Yes	2	4	8
559	S:S:A324	S:S:H413	5.85	No	No	0	5	7
560	S:S:G325	S:S:Y418	10.14	No	Yes	0	4	7
561	S:S:M473	S:S:Q326	4.08	Yes	No	0	4	3
562	S:S:I327	S:S:P328	3.39	Yes	No	0	6	4
563	S:S:F330	S:S:I327	6.28	Yes	Yes	2	8	6
564	S:S:I327	S:S:L414	2.85	Yes	Yes	2	6	6
565	S:S:I327	S:S:Y418	3.63	Yes	Yes	2	6	7
566	S:S:I327	S:S:Y421	9.67	Yes	Yes	2	6	8
567	S:S:G329	S:S:P328	2.03	No	No	0	5	4
568	S:S:N472	S:S:P328	3.26	No	No	0	4	4
569	S:S:F330	S:S:L334	12.18	Yes	Yes	2	8	6
570	S:S:F330	S:S:L414	6.09	Yes	Yes	2	8	6
571	S:S:E332	S:S:R331	2.33	No	Yes	0	5	4
572	S:S:K335	S:S:R331	12.38	No	Yes	2	4	4
573	S:S:I409	S:S:R331	2.51	Yes	Yes	2	5	4
574	S:S:R331	S:S:Y411	13.38	Yes	Yes	0	4	5
575	S:S:L334	S:S:Y408	11.72	Yes	Yes	2	6	3
576	S:S:I409	S:S:L334	2.85	Yes	Yes	2	5	6
577	S:S:L334	S:S:Y411	4.69	Yes	Yes	0	6	5
578	S:S:K335	S:S:S402	3.06	No	No	0	4	4
579	S:S:I409	S:S:K335	14.54	Yes	No	2	5	4
580	S:S:K336	S:S:K341	2.87	No	No	0	4	3
581	S:S:F351	S:S:V337	6.55	Yes	No	2	6	5
582	S:S:V337	S:S:Y408	6.31	No	Yes	2	5	3
583	S:S:H338	S:S:P339	7.63	Yes	No	2	4	7
584	S:S:H338	S:S:R340	10.16	Yes	No	0	4	4
585	S:S:H338	S:S:K341	11.79	Yes	No	0	4	3
586	S:S:H338	S:S:W352	3.17	Yes	Yes	2	4	8
587	S:S:P339	S:S:W352	28.38	No	Yes	2	7	8
588	S:S:L360	S:S:P339	3.28	No	No	0	4	7
589	S:S:G397	S:S:R340	4.5	No	No	0	5	4
590	S:S:N345	S:S:S342	2.98	Yes	No	2	8	3
591	S:S:A348	S:S:S342	3.42	No	No	2	5	3
592	S:S:H344	S:S:V343	6.92	No	No	0	3	3
593	S:S:A348	S:S:N345	4.69	No	Yes	2	5	8
594	S:S:A348	S:S:K349	3.21	No	No	0	5	3
595	S:S:E350	S:S:E354	2.54	Yes	No	2	5	4
596	S:S:F351	S:S:W352	3.01	Yes	Yes	2	6	8
597	S:S:F351	S:S:T355	2.59	Yes	Yes	2	6	4
598	S:S:F351	S:S:I401	6.28	Yes	Yes	2	6	7
599	S:S:F351	S:S:Y408	19.6	Yes	Yes	2	6	3
600	S:S:F356	S:S:W352	17.04	Yes	Yes	2	8	8
601	S:S:E399	S:S:W352	5.45	No	Yes	2	8	8
602	S:S:E353	S:S:L360	2.65	No	No	0	7	4
603	S:S:F356	S:S:T355	10.38	Yes	Yes	2	8	4
604	S:S:I401	S:S:T355	4.56	Yes	Yes	2	7	4
605	S:S:T355	S:S:V404	4.76	Yes	No	2	4	4
606	S:S:T355	S:S:T406	3.14	Yes	No	2	4	4
607	S:S:E399	S:S:F356	15.16	No	Yes	2	8	8
608	S:S:F356	S:S:I401	2.51	Yes	Yes	2	8	7
609	S:S:F356	S:S:V404	3.93	Yes	No	2	8	4
610	S:S:C358	S:S:P393	3.77	No	No	0	9	1
611	S:S:C358	S:S:C395	7.28	No	No	0	9	9
612	S:S:H359	S:S:Q361	13.6	No	No	0	4	1
613	S:S:H359	S:S:R392	10.16	No	No	0	4	1
614	S:S:C395	S:S:L360	7.94	No	No	0	9	4
615	S:S:F391	S:S:R392	9.62	No	No	0	1	1
616	S:S:G397	S:S:T396	3.64	No	No	0	5	6
617	S:S:D398	S:S:T396	11.56	No	No	0	3	6
618	S:S:E399	S:S:T396	8.47	No	No	0	8	6
619	S:S:N400	S:S:S402	4.47	No	No	0	4	4
620	S:S:I401	S:S:I409	4.42	Yes	Yes	2	7	5
621	S:S:D410	S:S:E405	9.09	No	No	0	6	4
622	S:S:P407	S:S:T406	3.5	Yes	No	2	1	4
623	S:S:I409	S:S:Y408	6.04	Yes	Yes	2	5	3
624	S:S:L414	S:S:Y411	8.21	Yes	Yes	0	6	5
625	S:S:H413	S:S:T412	5.48	No	No	0	7	5
626	S:S:H413	S:S:R415	13.54	No	No	0	7	5
627	S:S:L414	S:S:S417	4.5	Yes	No	2	6	6
628	S:S:R415	X:X:?2	6.99	No	Yes	0	5	0
629	S:S:I416	S:S:N419	2.83	Yes	No	0	4	7
630	S:S:I416	X:X:?2	6.57	Yes	Yes	2	4	0
631	S:S:S417	X:X:?2	5.18	No	Yes	2	6	0
632	S:S:Y418	S:S:Y421	2.98	Yes	Yes	2	7	8
633	S:S:L422	S:S:Y418	7.03	No	Yes	0	8	7
634	S:S:N471	S:S:Y418	5.81	Yes	Yes	2	6	7
635	S:S:M473	S:S:Y418	3.59	Yes	Yes	2	4	7
636	S:S:Y421	S:S:Y425	6.95	Yes	Yes	2	8	8
637	S:S:L422	S:S:V477	4.47	No	No	0	8	6
638	S:S:H429	S:S:Y425	6.53	No	Yes	2	6	8
639	S:S:F469	S:S:Y425	2.06	Yes	Yes	2	8	8
640	S:S:L464	S:S:S426	3	Yes	Yes	0	7	7
641	S:S:L467	S:S:S426	3	No	Yes	2	7	7
642	S:S:F469	S:S:S426	2.64	Yes	Yes	2	8	7
643	S:S:F479	S:S:S426	3.96	Yes	Yes	2	8	7
644	S:S:I427	S:S:L464	4.28	Yes	Yes	0	5	7
645	S:S:F469	S:S:H429	19.23	Yes	No	2	8	6
646	S:S:A430	S:S:L464	3.15	No	Yes	0	8	7
647	S:S:L431	S:S:V455	2.98	No	Yes	11	8	4
648	S:S:Q432	S:S:T436	5.67	No	No	0	7	4
649	S:S:D433	S:S:H463	2.52	No	Yes	0	4	5
650	S:S:A450	S:S:I434	4.87	No	No	0	3	6
651	S:S:I434	S:S:V455	3.07	No	Yes	0	6	4
652	S:S:H463	S:S:I434	14.58	Yes	No	0	5	6
653	S:S:T436	S:S:Y435	4.99	No	No	0	4	3
654	S:S:I452	S:S:Y435	4.84	No	No	0	3	3
655	S:S:C437	S:S:G442	1.96	No	No	39	6	4
656	S:S:C437	S:S:C449	7.28	No	No	39	6	7
657	S:S:L438	S:S:P439	3.28	No	No	0	3	2
658	S:S:G440	S:S:G447	2.11	No	No	0	3	1
659	S:S:G442	S:S:G447	2.11	No	No	0	4	1
660	S:S:C449	S:S:G442	1.96	No	No	39	7	4
661	S:S:K462	S:S:L443	14.1	Yes	No	11	4	3
662	S:S:H463	S:S:L443	6.43	Yes	No	0	5	3
663	S:S:H466	S:S:L443	3.86	No	No	11	4	3
664	S:S:F444	S:S:S448	2.64	Yes	No	0	3	3
665	S:S:A450	S:S:F444	4.16	No	Yes	11	3	3
666	S:S:F444	S:S:W458	5.01	Yes	Yes	11	3	4
667	S:S:F444	S:S:Q459	4.68	Yes	Yes	11	3	7
668	S:S:F444	S:S:K462	2.48	Yes	Yes	11	3	4
669	S:S:F444	S:S:H463	4.53	Yes	Yes	0	3	5
670	S:S:N446	S:S:T445	5.85	No	No	0	3	1
671	R:R:K52	S:S:T445	7.51	No	No	0	3	1
672	S:S:A450	S:S:Q459	7.58	No	Yes	11	3	7
673	S:S:D451	S:S:K453	6.91	No	No	0	3	2
674	S:S:I452	S:S:K453	4.36	No	No	0	3	2
675	S:S:K453	S:S:K454	2.87	No	No	0	2	3
676	S:S:Q459	S:S:V455	4.3	Yes	Yes	11	7	4
677	S:S:E456	S:S:W458	7.63	No	Yes	11	5	4
678	S:S:E456	S:S:Q459	8.92	No	Yes	11	5	7
679	R:R:R54	S:S:E456	5.82	No	No	11	2	5
680	S:S:Q459	S:S:W458	16.43	Yes	Yes	11	7	4
681	R:R:R54	S:S:W458	14.99	No	Yes	11	2	4
682	R:R:P55	S:S:W458	13.51	Yes	Yes	11	6	4
683	S:S:L461	S:S:R465	2.43	Yes	No	11	7	5
684	R:R:L51	S:S:L461	4.15	Yes	Yes	11	6	7
685	S:S:H466	S:S:K462	3.93	No	Yes	11	4	4
686	R:R:D50	S:S:K462	4.15	No	Yes	0	3	4
687	R:R:L51	S:S:K462	8.46	Yes	Yes	11	6	4
688	R:R:L51	S:S:R465	9.72	Yes	No	11	6	5
689	S:S:F469	S:S:L467	3.65	Yes	No	2	8	7
690	S:S:F479	S:S:L467	2.44	Yes	No	2	8	7
691	S:S:N468	S:S:Q476	6.6	No	No	28	6	3
692	S:S:N468	S:S:T478	5.85	No	No	28	6	3
693	H:H:?7	S:S:N468	29.4	No	No	28	0	6
694	S:S:F469	S:S:V477	9.18	Yes	No	0	8	6
695	S:S:G474	S:S:T470	1.82	No	No	0	5	5
696	S:S:Q476	S:S:T470	5.67	No	No	0	3	5
697	S:S:M473	S:S:N471	7.01	Yes	Yes	2	4	6
698	S:S:G474	S:S:N471	3.39	No	Yes	0	5	6
699	S:S:E475	S:S:N471	10.52	No	Yes	2	5	6
700	S:S:M473	S:S:N472	5.61	Yes	No	0	4	4
701	S:S:E475	S:S:M473	5.41	No	Yes	2	5	4
702	H:H:?7	S:S:Q476	5.94	No	No	28	0	3
703	S:S:L485	S:S:V477	2.98	No	No	0	4	6
704	H:H:?7	S:S:T478	3.94	No	No	28	0	3
705	S:S:F479	S:S:L485	7.31	Yes	No	0	8	4
706	S:S:D480	S:S:D484	3.99	No	Yes	0	7	8
707	S:S:C482	S:S:D484	3.11	No	Yes	2	7	8
708	S:S:V486	S:S:V513	3.21	No	Yes	2	3	3
709	S:S:V486	S:S:Y514	2.52	No	Yes	2	3	4
710	S:S:G487	S:S:V513	1.84	No	Yes	0	6	3
711	S:S:N488	S:S:N512	5.45	No	Yes	2	4	4
712	S:S:N488	S:S:V513	4.43	No	Yes	2	4	3
713	S:S:N488	S:S:Y514	9.3	No	Yes	2	4	4
714	S:S:Y489	S:S:Y511	3.97	Yes	Yes	2	8	5
715	S:S:I491	S:S:V508	3.07	No	No	0	8	7
716	S:S:G509	S:S:I491	5.29	No	No	0	9	8
717	S:S:F505	S:S:I492	7.54	No	No	0	4	5
718	S:S:H495	S:S:N493	10.2	No	No	0	7	9
719	S:S:I528	S:S:N493	4.25	Yes	No	0	7	9
720	S:S:I503	S:S:W494	4.7	No	Yes	8	4	7
721	S:S:F505	S:S:W494	12.03	No	Yes	8	4	7
722	S:S:H495	S:S:K506	14.41	No	No	0	7	5
723	S:S:H495	S:S:L529	12.86	No	No	0	7	4
724	S:S:P498	S:S:S497	3.56	No	Yes	0	3	3
725	S:S:D500	S:S:S497	4.42	No	Yes	0	4	3
726	S:S:G501	S:S:S497	1.86	No	Yes	0	5	3
727	S:S:S497	S:S:S502	3.26	Yes	No	0	3	4
728	S:S:S497	S:S:V504	3.23	Yes	No	0	3	3
729	S:S:E499	S:S:P498	11	No	No	0	4	3
730	S:S:K506	S:S:K527	5.75	No	Yes	0	5	3
731	S:S:E507	S:S:K527	2.7	No	Yes	0	5	3
732	S:S:I528	S:S:V508	9.22	Yes	No	0	7	7
733	S:S:N512	S:S:Y510	2.33	Yes	No	0	4	3
734	S:S:F522	S:S:Y510	14.44	No	No	0	1	3
735	S:S:V513	S:S:Y511	2.52	Yes	Yes	2	3	5
736	S:S:R520	S:S:Y511	13.38	No	Yes	2	3	5
737	S:S:L521	S:S:Y511	3.52	Yes	Yes	2	5	5
738	S:S:N512	S:S:Y514	5.81	Yes	Yes	2	4	4
739	S:S:A515	S:S:N512	4.69	No	Yes	0	4	4
740	S:S:V513	S:S:Y514	7.57	Yes	Yes	2	3	4
741	S:S:A515	S:S:E519	4.53	No	No	0	4	4
742	S:S:E519	S:S:K516	22.95	No	No	0	4	2
743	S:S:K517	S:S:R520	2.48	No	No	0	1	3
744	S:S:I523	S:S:L521	8.56	No	Yes	2	6	5
745	S:S:E526	S:S:N524	13.15	No	No	40	3	5
746	S:S:K527	S:S:N524	9.79	Yes	No	40	3	5
747	S:S:E525	S:S:I528	6.83	Yes	Yes	2	4	7
748	S:S:E525	S:S:W530	8.72	Yes	Yes	2	4	8
749	S:S:E525	S:S:V537	4.28	Yes	Yes	2	4	4
750	S:S:E526	S:S:K527	2.7	No	Yes	40	3	3
751	S:S:E526	S:S:R535	2.33	No	No	0	3	4
752	S:S:I528	S:S:W530	5.87	Yes	Yes	2	7	8
753	S:S:V537	S:S:W530	12.26	Yes	Yes	2	4	8
754	S:S:P538	S:S:W530	18.92	No	Yes	2	8	8
755	S:S:F533	S:S:S531	5.28	No	No	0	1	4
756	S:S:F533	S:S:S534	2.64	No	No	0	1	4
757	S:S:E536	S:S:S534	5.75	No	No	0	5	4
758	S:S:P538	S:S:V537	3.53	No	Yes	2	8	4
759	S:S:F539	S:S:N541	8.46	Yes	No	2	1	5
760	S:S:F539	S:S:R544	2.14	Yes	No	0	1	5
761	H:H:?1	S:S:F539	7.6	Yes	Yes	2	0	1
762	H:H:?1	S:S:N541	28.17	Yes	No	2	0	5
763	S:S:C542	S:S:C561	1.82	No	Yes	2	9	9
764	S:S:C542	S:S:C562	7.28	No	No	2	9	9
765	S:S:F563	S:S:S543	7.93	No	No	0	7	8
766	S:S:D545	S:S:T577	4.34	No	No	0	5	5
767	H:H:?1	S:S:D545	6.05	Yes	No	0	0	5
768	S:S:C546	S:S:T550	6.76	Yes	Yes	27	9	6
769	S:S:C546	S:S:K552	3.23	Yes	No	27	9	8
770	S:S:C546	S:S:F563	4.19	Yes	No	27	9	7
771	S:S:C546	S:S:C565	7.28	Yes	No	27	9	9
772	S:S:L547	S:S:T550	2.95	No	Yes	0	1	6
773	S:S:A548	S:S:G549	1.95	No	No	0	4	9
774	S:S:G549	S:S:S574	1.86	No	No	0	9	8
775	S:S:G549	S:S:T596	1.82	No	Yes	0	9	5
776	S:S:C565	S:S:T550	6.76	No	Yes	27	9	6
777	S:S:E567	S:S:T550	5.64	No	Yes	0	4	6
778	S:S:R551	S:S:V566	13.08	No	No	0	7	4
779	S:S:C582	S:S:R551	4.18	No	No	0	9	7
780	R:R:R551	S:S:R551	23.46	No	No	0	7	7
781	S:S:F563	S:S:K552	31.02	No	No	27	7	8
782	S:S:D578	S:S:K552	8.3	No	No	0	7	8
783	R:R:K552	S:S:I554	8.72	No	No	0	8	3
784	R:R:I554	S:S:I554	2.94	No	No	0	3	3
785	R:R:S580	S:S:I554	3.1	No	No	0	4	3
786	S:S:E558	S:S:I555	5.47	No	No	0	5	5
787	S:S:E564	S:S:I555	8.2	No	No	0	6	5
788	S:S:E556	S:S:G557	3.27	No	No	0	6	6
789	R:R:D234	S:S:G557	5.03	No	No	41	5	6
790	I:I:?2	S:S:G557	3.14	No	No	41	0	6
791	S:S:E558	S:S:P559	6.29	No	Yes	0	5	6
792	I:I:?2	S:S:E558	2.43	No	No	0	0	5
793	S:S:C562	S:S:P559	3.77	No	Yes	2	9	6
794	S:S:E567	S:S:H595	7.39	No	Yes	0	4	5
795	S:S:C568	S:S:P569	1.88	Yes	Yes	1	9	5
796	S:S:C568	S:S:S574	3.44	Yes	No	0	9	8
797	S:S:C568	S:S:C582	7.28	Yes	No	1	9	9
798	S:S:C568	S:S:H595	2.95	Yes	Yes	0	9	5
799	S:S:E572	S:S:P569	7.86	No	Yes	0	7	5
800	S:S:C582	S:S:P569	1.88	No	Yes	1	9	5
801	R:R:P569	S:S:P569	7.79	Yes	Yes	1	5	5
802	S:S:D570	S:S:H595	11.35	No	Yes	0	5	5
803	S:S:G571	S:S:K584	3.49	No	No	10	7	4
804	S:S:G571	S:S:W590	9.85	No	Yes	10	7	6
805	S:S:G571	S:S:S591	3.71	No	Yes	10	7	8
806	S:S:E572	S:S:K584	5.4	No	No	0	7	4
807	S:S:D575	S:S:Y573	4.6	No	Yes	0	8	6
808	S:S:N583	S:S:Y573	12.79	No	Yes	0	1	6
809	S:S:C585	S:S:Y573	5.38	Yes	Yes	10	9	6
810	S:S:C598	S:S:Y573	2.69	Yes	Yes	10	9	6
811	S:S:D575	S:S:E576	7.8	No	No	0	8	3
812	S:S:A579	S:S:E576	6.03	No	No	0	7	3
813	R:R:I554	S:S:S580	3.1	No	No	0	3	4
814	R:R:E556	S:S:S580	11.5	No	No	0	6	4
815	S:S:K584	S:S:W590	3.48	No	Yes	10	4	6
816	S:S:C585	S:S:P586	3.77	Yes	No	10	9	4
817	S:S:C585	S:S:C598	5.46	Yes	Yes	10	9	9
818	S:S:F589	S:S:P586	10.11	No	No	10	5	4
819	S:S:C598	S:S:P586	1.88	Yes	No	10	9	4
820	S:S:D587	S:S:D588	14.64	No	Yes	10	3	6
821	S:S:D587	S:S:Q754	6.53	No	Yes	10	3	4
822	S:S:D588	S:S:R752	3.57	Yes	No	10	6	3
823	S:S:D588	S:S:Q754	2.61	Yes	Yes	10	6	4
824	S:S:D588	S:S:I761	5.6	Yes	Yes	10	6	7
825	S:S:C598	S:S:F589	2.79	Yes	No	10	9	5
826	S:S:A600	S:S:F589	2.77	No	No	0	4	5
827	S:S:S591	S:S:W590	2.47	Yes	Yes	10	8	6
828	S:S:K601	S:S:W590	2.32	No	Yes	10	8	6
829	S:S:D758	S:S:W590	2.23	No	Yes	10	4	6
830	S:S:E759	S:S:W590	13.08	No	Yes	10	4	6
831	S:S:H595	S:S:S591	5.58	Yes	Yes	0	5	8
832	S:S:N592	S:S:T596	2.92	Yes	Yes	29	7	5
833	S:S:N592	S:S:S597	10.43	Yes	No	29	7	1
834	S:S:I599	S:S:N592	11.33	No	Yes	0	4	7
835	H:H:?8	S:S:N592	7.35	Yes	Yes	29	0	7
836	H:H:?8	S:S:E593	10.64	Yes	No	0	0	2
837	H:H:?8	S:S:N594	30.62	Yes	No	0	0	3
838	S:S:S597	S:S:T596	3.2	No	Yes	29	1	5
839	H:H:?8	S:S:T596	15.78	Yes	Yes	29	0	5
840	S:S:K601	S:S:Q754	6.78	No	Yes	10	8	4
841	S:S:I761	S:S:K601	8.72	Yes	No	10	7	8
842	S:S:E602	S:S:I760	4.1	No	Yes	0	3	5
843	S:S:F605	S:S:I603	2.51	Yes	Yes	0	7	4
844	S:S:I603	S:S:R752	2.51	Yes	No	10	4	3
845	S:S:I603	S:S:I761	5.89	Yes	Yes	10	4	7
846	S:S:I603	S:S:I763	7.36	Yes	No	0	4	7
847	S:S:E604	S:S:I760	2.73	No	Yes	42	6	5
848	S:S:E604	S:S:F762	4.66	No	Yes	42	6	7
849	S:S:E604	S:S:K831	9.45	No	No	0	6	9
850	S:S:F605	S:S:S607	9.25	Yes	No	0	7	7
851	S:S:E671	S:S:F605	10.49	No	Yes	0	4	7
852	S:S:F605	S:S:P672	5.78	Yes	Yes	0	7	9
853	S:S:E610	S:S:L606	3.98	Yes	Yes	0	7	9
854	S:S:I669	S:S:L606	2.85	Yes	Yes	0	8	9
855	S:S:F832	S:S:L606	2.44	Yes	Yes	0	5	9
856	S:S:L606	S:S:S834	3	Yes	No	0	9	8
857	S:S:E610	S:S:S607	5.75	Yes	No	0	7	7
858	S:S:T617	S:S:W608	7.28	No	Yes	0	5	5
859	S:S:I669	S:S:W608	4.7	Yes	Yes	0	8	5
860	S:S:G670	S:S:W608	4.22	No	Yes	0	7	5
861	S:S:E610	S:S:K831	2.7	Yes	No	0	7	9
862	S:S:F612	S:S:L616	2.44	Yes	No	0	8	8
863	S:S:F612	S:S:F832	11.79	Yes	Yes	9	8	5
864	S:S:A835	S:S:F612	4.16	No	Yes	9	8	8
865	S:S:F612	S:S:I839	2.51	Yes	No	9	8	7
866	R:R:I822	S:S:F612	2.51	Yes	Yes	9	7	8
867	R:R:P823	S:S:F612	5.78	Yes	Yes	9	9	8
868	S:S:I669	S:S:L616	2.85	Yes	No	0	8	8
869	S:S:L616	S:S:V838	7.45	No	No	0	8	7
870	S:S:L666	S:S:T617	2.95	No	No	0	7	5
871	S:S:A620	S:S:L666	3.15	No	No	0	7	7
872	S:S:L622	S:S:L626	2.77	No	No	0	3	4
873	S:S:F846	S:S:L622	2.44	No	No	0	6	3
874	S:S:F662	S:S:G623	7.53	Yes	No	43	8	6
875	S:S:F846	S:S:G623	3.01	No	No	43	6	6
876	S:S:L659	S:S:T627	4.42	No	No	0	4	7
877	S:S:F662	S:S:T627	6.49	Yes	No	0	8	7
878	S:S:L849	S:S:T627	5.9	No	No	0	8	7
879	S:S:F629	S:S:V633	5.24	No	No	44	3	5
880	S:S:F629	S:S:L861	2.44	No	No	44	3	5
881	S:S:L655	S:S:V630	4.47	No	No	7	9	7
882	S:S:F853	S:S:V630	5.24	Yes	No	7	9	7
883	S:S:I857	S:S:V630	6.14	Yes	No	0	8	7
884	S:S:I635	S:S:L631	5.71	No	No	7	4	4
885	S:S:L631	S:S:Y652	2.34	No	No	7	4	7
886	S:S:L631	S:S:L655	13.84	No	No	7	4	9
887	S:S:I857	S:S:V633	3.07	Yes	No	0	8	5
888	S:S:L861	S:S:V633	2.98	No	No	44	5	5
889	S:S:F634	S:S:V643	10.49	Yes	No	0	9	9
890	S:S:F634	S:S:S651	7.93	Yes	No	0	9	9
891	S:S:F634	S:S:K856	4.96	Yes	No	0	9	9
892	S:S:F634	S:S:I857	2.51	Yes	Yes	0	9	8
893	S:S:I635	S:S:Y652	2.42	No	No	7	4	7
894	S:S:F637	S:S:T640	5.19	No	No	0	4	9
895	S:S:F637	S:S:I860	7.54	No	No	0	4	9
896	S:S:N639	S:S:R638	7.23	No	No	0	4	6
897	S:S:R638	S:S:R648	4.26	No	No	0	6	8
898	S:S:P641	S:S:T640	3.5	No	No	0	8	9
899	S:S:T640	S:S:T868	4.71	No	No	0	9	6
900	S:S:K644	S:S:P641	3.35	No	No	0	8	8
901	S:S:E870	S:S:P641	4.72	No	No	0	7	8
902	S:S:I642	S:S:V643	3.07	Yes	No	0	7	9
903	S:S:F801	S:S:I642	6.28	No	Yes	0	9	7
904	S:S:I642	S:S:I860	5.89	Yes	No	0	7	9
905	S:S:I642	S:S:T868	7.6	Yes	No	0	7	6
906	S:S:K644	S:S:R648	8.66	No	No	0	8	8
907	S:S:K698	S:S:T646	3	Yes	No	0	9	9
908	S:S:N700	S:S:T646	5.85	No	No	0	7	9
909	S:S:N800	S:S:T646	7.31	Yes	No	0	7	9
910	S:S:L650	S:S:N647	10.98	Yes	No	7	8	9
911	S:S:N647	S:S:Q724	14.52	No	Yes	7	9	8
912	S:S:R648	S:S:Y652	4.12	No	No	0	8	7
913	S:S:C694	S:S:L650	4.76	Yes	Yes	0	6	8
914	S:S:K698	S:S:L650	7.05	Yes	Yes	7	9	8
915	S:S:L650	S:S:Q724	2.66	Yes	Yes	7	8	8
916	S:S:L653	S:S:L690	4.15	No	Yes	0	5	7
917	S:S:C694	S:S:L653	3.17	Yes	No	0	6	5
918	S:S:C691	S:S:L654	4.76	Yes	Yes	7	8	8
919	S:S:C694	S:S:L654	7.94	Yes	Yes	0	6	8
920	S:S:I695	S:S:L654	5.71	No	Yes	0	7	8
921	S:S:K698	S:S:L654	2.82	Yes	Yes	7	9	8
922	S:S:F853	S:S:L654	6.09	Yes	Yes	7	9	8
923	S:S:F853	S:S:L655	8.53	Yes	No	7	9	9
924	S:S:C660	S:S:F656	5.59	No	No	0	7	4
925	S:S:F656	S:S:L690	2.44	No	Yes	0	4	7
926	S:S:L690	S:S:S657	9.01	Yes	No	0	7	9
927	S:S:C691	S:S:S657	6.89	Yes	No	0	8	9
928	S:S:C691	S:S:L658	3.17	Yes	No	7	8	8
929	S:S:L658	S:S:L848	2.77	No	Yes	7	8	7
930	S:S:L658	S:S:L849	4.15	No	No	0	8	8
931	S:S:C660	S:S:S687	5.16	No	No	0	7	6
932	S:S:C661	S:S:F684	2.79	No	Yes	0	7	8
933	S:S:C661	S:S:S687	5.16	No	No	0	7	6
934	S:S:C661	S:S:S845	3.44	No	No	0	7	8
935	S:S:F662	S:S:S845	10.57	Yes	No	0	8	8
936	S:S:F662	S:S:F846	5.36	Yes	No	43	8	6
937	S:S:F684	S:S:S664	5.28	Yes	No	0	8	6
938	S:S:L666	S:S:S665	3	No	No	0	7	8
939	S:S:L842	S:S:S665	3	No	No	0	9	8
940	S:S:F667	S:S:L679	7.31	No	No	45	5	5
941	S:S:F667	S:S:R680	2.14	No	Yes	0	5	8
942	S:S:A683	S:S:F667	2.77	No	No	45	5	5
943	S:S:F668	S:S:R680	13.9	Yes	Yes	0	9	8
944	S:S:E837	S:S:F668	10.49	Yes	Yes	0	9	9
945	S:S:F668	S:S:V838	3.93	Yes	No	0	9	7
946	S:S:F668	S:S:I841	3.77	Yes	Yes	0	9	9
947	S:S:E671	S:S:Q673	5.1	No	No	0	4	4
948	S:S:C677	S:S:P672	1.88	Yes	Yes	22	9	9
949	S:S:I763	S:S:P672	8.47	No	Yes	0	7	9
950	S:S:C765	S:S:P672	1.88	No	Yes	22	9	9
951	S:S:Q673	S:S:W675	17.52	No	No	0	4	3
952	S:S:D674	S:S:S750	2.94	No	No	0	3	6
953	S:S:T676	S:S:W675	7.28	No	No	0	7	3
954	S:S:R680	S:S:T676	3.88	Yes	No	0	8	7
955	S:S:C677	S:S:P748	1.88	Yes	Yes	22	9	9
956	S:S:C677	S:S:S750	3.44	Yes	No	0	9	6
957	S:S:C677	S:S:C765	7.28	Yes	No	22	9	9
958	S:S:L743	S:S:R678	2.43	No	No	0	7	5
959	S:S:P747	S:S:R678	7.21	No	No	22	8	5
960	S:S:P748	S:S:R678	7.21	Yes	No	22	9	5
961	S:S:A683	S:S:L679	3.15	No	No	45	5	5
962	S:S:Q681	S:S:R680	7.01	No	Yes	0	9	8
963	S:S:C765	S:S:R680	6.96	No	Yes	0	9	8
964	S:S:L773	S:S:Q681	5.32	No	No	0	8	9
965	S:S:Q681	X:X:?4	7.94	No	Yes	0	9	0
966	S:S:C739	S:S:P682	3.77	No	No	0	7	5
967	S:S:P682	S:S:W742	4.05	No	Yes	0	5	9
968	S:S:F684	S:S:F688	10.72	Yes	Yes	0	8	8
969	S:S:F684	S:S:W818	6.01	Yes	Yes	12	8	9
970	S:S:F684	S:S:I841	15.07	Yes	Yes	12	8	9
971	S:S:F684	X:X:?4	19.98	Yes	Yes	12	8	0
972	S:S:G685	S:S:Q735	4.93	No	Yes	0	8	9
973	S:S:G685	X:X:?4	2.55	No	Yes	0	8	0
974	S:S:I686	S:S:Q735	4.12	No	Yes	0	7	9
975	S:S:I686	S:S:I736	2.94	No	No	0	7	5
976	S:S:F688	S:S:I692	8.79	Yes	Yes	0	8	7
977	S:S:F688	S:S:F814	7.5	Yes	Yes	0	8	9
978	S:S:A844	S:S:F688	2.77	No	Yes	0	9	8
979	S:S:F688	S:S:L848	3.65	Yes	Yes	0	8	7
980	S:S:T732	S:S:V689	4.76	No	Yes	0	7	7
981	S:S:Q735	S:S:V689	17.19	Yes	Yes	46	9	7
982	S:S:V689	S:S:Y779	2.52	Yes	No	46	7	9
983	S:S:T780	S:S:V689	3.17	No	Yes	0	7	7
984	S:S:L783	S:S:V689	2.98	No	Yes	0	9	7
985	S:S:L690	S:S:T732	5.9	Yes	No	0	7	7
986	S:S:C691	S:S:L848	6.35	Yes	Yes	7	8	7
987	S:S:A784	S:S:I692	3.25	No	Yes	12	8	7
988	S:S:C787	S:S:I692	3.27	No	Yes	12	8	7
989	S:S:I692	S:S:M811	2.92	Yes	No	12	7	9
990	S:S:S693	S:S:V728	3.23	No	No	0	9	7
991	S:S:I695	S:S:I807	2.94	No	Yes	0	7	9
992	S:S:I695	S:S:L848	4.28	No	Yes	0	7	7
993	S:S:C787	S:S:L696	6.35	No	No	0	8	8
994	S:S:F790	S:S:L696	3.65	Yes	No	0	7	8
995	S:S:L727	S:S:V697	2.98	No	No	0	7	8
996	S:S:V697	S:S:V728	3.21	No	No	0	8	7
997	S:S:F853	S:S:K698	2.48	Yes	Yes	7	9	9
998	S:S:R701	S:S:T699	7.76	No	No	0	8	9
999	S:S:T699	S:S:V702	6.35	No	No	0	9	9
1000	S:S:R701	S:S:S794	2.64	No	No	0	8	9
1001	S:S:E799	S:S:R701	12.79	No	No	0	8	8
1002	S:S:V702	S:S:V705	3.21	No	No	0	9	9
1003	S:S:F790	S:S:V702	2.62	Yes	No	0	7	9
1004	S:S:K717	S:S:W719	13.92	No	No	0	6	6
1005	S:S:L723	S:S:W719	4.56	No	No	0	7	6
1006	S:S:L721	S:S:N722	2.75	No	No	0	6	3
1007	S:S:L726	S:S:N722	2.75	No	No	0	4	3
1008	S:S:F725	S:S:Q724	7.03	No	Yes	0	5	8
1009	S:S:F725	S:S:F729	2.14	No	No	0	5	3
1010	S:S:I736	S:S:T732	3.04	No	No	0	5	7
1011	S:S:F733	S:S:V737	9.18	No	No	0	4	3
1012	S:S:I738	S:S:M734	2.92	No	No	0	8	4
1013	S:S:M734	S:S:Y779	7.18	No	No	0	4	9
1014	S:S:I738	S:S:Q735	2.74	No	Yes	0	8	9
1015	S:S:L776	S:S:Q735	5.32	No	Yes	0	8	9
1016	S:S:Q735	S:S:Y779	4.51	Yes	No	46	9	9
1017	S:S:F775	S:S:I738	6.28	No	No	0	4	8
1018	S:S:P748	S:S:W742	9.46	Yes	Yes	0	9	9
1019	S:S:E767	S:S:W742	3.27	Yes	Yes	0	7	9
1020	S:S:S769	S:S:W742	4.94	No	Yes	0	9	9
1021	S:S:A772	S:S:W742	5.19	No	Yes	0	6	9
1022	S:S:A746	S:S:P747	1.87	No	No	0	6	8
1023	S:S:A746	S:S:S769	3.42	No	No	0	6	9
1024	S:S:P747	S:S:P748	1.95	No	Yes	22	8	9
1025	S:S:H766	S:S:S749	2.79	Yes	No	0	6	5
1026	S:S:N753	S:S:Y751	10.47	No	No	0	7	3
1027	S:S:T764	S:S:Y751	2.5	No	No	0	7	3
1028	S:S:H766	S:S:Y751	6.53	Yes	No	0	6	3
1029	S:S:I761	S:S:R752	7.52	Yes	No	10	7	3
1030	S:S:E755	S:S:N753	6.57	No	No	0	4	7
1031	S:S:I761	S:S:Q754	5.49	Yes	Yes	10	7	4
1032	S:S:F762	S:S:L756	8.53	Yes	No	0	7	5
1033	S:S:E757	S:S:E759	6.34	No	No	0	4	4
1034	S:S:E757	S:S:I760	5.47	No	Yes	0	4	5
1035	S:S:D758	S:S:E759	3.9	No	No	10	4	4
1036	S:S:F762	S:S:I760	6.28	Yes	Yes	42	7	5
1037	S:S:F762	S:S:G830	4.52	Yes	No	0	7	8
1038	S:S:E767	S:S:H766	2.46	Yes	Yes	0	7	6
1039	S:S:G768	S:S:H766	3.18	No	Yes	0	7	6
1040	S:S:E767	S:S:L770	7.95	Yes	No	12	7	3
1041	S:S:E767	S:S:L773	2.65	Yes	No	0	7	8
1042	S:S:E767	X:X:?4	1.98	Yes	Yes	12	7	0
1043	S:S:L770	X:X:?4	6.19	No	Yes	12	3	0
1044	S:S:L773	S:S:L776	4.15	No	No	0	8	8
1045	S:S:I777	X:X:?4	19.15	No	Yes	0	8	0
1046	S:S:C781	S:S:G778	1.96	No	No	0	7	5
1047	S:S:T780	X:X:?4	6.59	No	Yes	0	7	0
1048	S:S:I786	S:S:L782	2.85	No	No	0	4	4
1049	S:S:A784	S:S:F814	4.16	No	Yes	12	8	9
1050	S:S:A784	S:S:F815	2.77	No	No	12	8	7
1051	S:S:A785	S:S:F815	2.77	No	No	0	2	7
1052	S:S:F790	S:S:I786	2.51	Yes	No	0	7	4
1053	S:S:C787	S:S:M811	3.24	No	No	12	8	9
1054	S:S:F788	S:S:T808	3.89	No	No	0	8	9
1055	S:S:F788	S:S:M811	4.98	No	No	0	8	9
1056	S:S:F789	S:S:F790	5.36	No	Yes	0	4	7
1057	S:S:F789	S:S:K793	3.72	No	No	0	4	7
1058	S:S:A791	S:S:I807	3.25	No	Yes	0	9	9
1059	S:S:F792	S:S:R795	16.03	No	No	0	8	9
1060	S:S:L797	S:S:S794	3	No	No	0	8	9
1061	S:S:A804	S:S:S794	3.42	No	No	0	9	9
1062	S:S:K796	S:S:R795	4.95	No	No	0	7	9
1063	S:S:E799	S:S:L797	5.3	No	No	0	8	8
1064	S:S:N802	S:S:P798	4.89	No	No	0	9	9
1065	S:S:A804	S:S:E799	6.03	No	No	0	9	8
1066	S:S:F801	S:S:N800	4.83	No	Yes	0	9	7
1067	S:S:K856	S:S:N800	9.79	No	Yes	0	9	7
1068	S:S:F801	S:S:I859	8.79	No	No	0	9	9
1069	S:S:K805	S:S:N802	6.99	Yes	No	0	9	9
1070	S:S:E803	S:S:F806	2.33	Yes	Yes	7	9	5
1071	S:S:E803	S:S:I807	2.73	Yes	Yes	7	9	9
1072	S:S:E803	S:S:I852	8.2	Yes	Yes	7	9	9
1073	S:S:E803	S:S:K856	10.8	Yes	No	0	9	9
1074	S:S:F806	S:S:K805	4.96	Yes	Yes	7	5	9
1075	S:S:F809	S:S:K805	8.69	Yes	Yes	7	9	9
1076	R:R:K805	S:S:K805	4.31	No	Yes	7	9	9
1077	S:S:F806	S:S:F809	3.22	Yes	Yes	7	5	9
1078	S:S:C851	S:S:F806	4.19	No	Yes	7	8	5
1079	S:S:F806	S:S:N855	15.71	Yes	No	0	5	9
1080	S:S:I807	S:S:I852	4.42	Yes	Yes	7	9	9
1081	S:S:C851	S:S:F809	2.79	No	Yes	7	8	9
1082	R:R:K805	S:S:F809	3.72	No	Yes	7	9	9
1083	R:R:F809	S:S:F809	7.5	No	Yes	0	9	9
1084	S:S:C851	S:S:S810	6.89	No	No	0	8	9
1085	S:S:I852	S:S:S810	6.19	Yes	No	0	9	9
1086	R:R:F809	S:S:L812	4.87	No	No	0	9	9
1087	S:S:G847	S:S:I813	3.53	No	No	0	8	8
1088	R:R:L812	S:S:I813	2.85	No	No	0	9	8
1089	S:S:F814	S:S:F815	11.79	Yes	No	12	9	7
1090	S:S:F814	S:S:W818	7.02	Yes	Yes	12	9	9
1091	R:R:I813	S:S:I816	5.89	No	No	0	8	8
1092	S:S:A843	S:S:V817	5.09	No	No	0	7	9
1093	R:R:I816	S:S:V817	4.61	No	No	0	8	9
1094	S:S:F821	S:S:W818	12.03	Yes	Yes	12	9	9
1095	S:S:A840	S:S:W818	7.78	No	Yes	12	9	9
1096	S:S:I841	S:S:W818	2.35	Yes	Yes	12	9	9
1097	S:S:A844	S:S:W818	2.59	No	Yes	0	9	9
1098	S:S:W818	X:X:?4	18.68	Yes	Yes	12	9	0
1099	R:R:S820	S:S:S820	4.89	No	No	0	7	7
1100	S:S:F821	S:S:Y825	11.35	Yes	Yes	12	9	9
1101	S:S:F821	S:S:V836	3.93	Yes	No	12	9	8
1102	S:S:E837	S:S:F821	2.33	Yes	Yes	12	9	9
1103	S:S:A840	S:S:F821	4.16	No	Yes	12	9	9
1104	S:S:F821	X:X:?4	1.82	Yes	Yes	12	9	0
1105	S:S:I822	S:S:P823	3.39	No	No	0	7	9
1106	R:R:F821	S:S:P823	7.22	Yes	No	0	9	9
1107	R:R:S820	S:S:A824	3.42	No	No	23	7	7
1108	R:R:F821	S:S:A824	2.77	Yes	No	23	9	7
1109	S:S:V833	S:S:Y825	5.05	No	Yes	0	6	9
1110	S:S:V836	S:S:Y825	2.52	No	Yes	12	8	9
1111	S:S:E837	S:S:Y825	5.61	Yes	Yes	12	9	9
1112	S:S:Y825	X:X:?4	10.49	Yes	Yes	12	9	0
1113	R:R:A824	S:S:S827	3.42	No	No	23	7	8
1114	R:R:V836	S:S:S827	3.23	No	No	23	8	8
1115	S:S:T828	S:S:V833	6.35	No	No	0	8	6
1116	R:R:S827	S:S:T828	3.2	No	No	0	8	8
1117	R:R:F832	S:S:Y829	2.06	No	No	0	5	6
1118	S:S:G830	S:S:V833	1.84	No	No	0	8	6
1119	S:S:F832	S:S:K831	12.41	Yes	No	0	5	9
1120	R:R:P823	S:S:F832	2.89	Yes	Yes	9	9	5
1121	R:R:S827	S:S:F832	3.96	No	Yes	0	8	5
1122	R:R:P823	S:S:A835	1.87	Yes	No	9	9	8
1123	S:S:E837	X:X:?4	6.91	Yes	Yes	12	9	0
1124	R:R:P823	S:S:I839	3.39	Yes	No	9	9	7
1125	S:S:I841	X:X:?4	2.13	Yes	Yes	12	9	0
1126	S:S:F854	S:S:L849	2.44	No	No	0	4	8
1127	S:S:A850	S:S:F854	6.93	No	No	0	1	4
1128	S:S:F853	S:S:I852	5.02	Yes	Yes	7	9	9
1129	S:S:F862	S:S:I857	5.02	No	Yes	0	5	8
1130	S:S:I859	S:S:Y858	2.42	No	No	0	9	8
1131	S:S:F862	S:S:Y858	19.6	No	No	0	5	8
1132	S:S:P864	S:S:Y858	2.78	No	No	0	8	8
1133	S:S:F862	S:S:L861	7.31	No	No	0	5	5
1134	S:S:K863	S:S:P864	5.02	No	No	0	7	8
1135	S:S:E870	S:S:I869	5.47	No	No	0	7	6
1136	S:S:E871	S:S:I869	27.33	No	No	0	5	6
1137	R:R:R25	R:R:Y20	10.29	No	Yes	0	4	2
1138	R:R:R96	R:R:Y20	6.17	Yes	Yes	1	4	2
1139	R:R:S113	R:R:Y20	8.9	No	Yes	1	4	2
1140	R:R:I135	R:R:Y20	10.88	No	Yes	0	4	2
1141	R:R:G21	R:R:P22	4.06	No	No	1	3	5
1142	R:R:E109	R:R:G21	4.91	Yes	No	1	5	3
1143	R:R:F98	R:R:P22	8.67	Yes	No	1	4	5
1144	R:R:E109	R:R:P22	3.14	Yes	No	1	5	5
1145	R:R:F347	R:R:Q24	12.88	Yes	No	0	5	5
1146	R:R:E350	R:R:Q24	6.37	Yes	No	0	5	5
1147	R:R:Q27	R:R:R25	10.51	No	No	0	4	4
1148	R:R:F98	R:R:R25	13.9	Yes	No	0	4	4
1149	R:R:A26	R:R:N345	4.69	No	Yes	1	6	8
1150	R:R:A26	R:R:F347	2.77	No	Yes	1	6	5
1151	R:R:Q27	R:R:R96	7.01	No	Yes	0	4	4
1152	R:R:E79	R:R:K28	4.05	No	No	0	7	5
1153	R:R:K28	R:R:Y95	14.33	No	Yes	1	5	8
1154	R:R:H344	R:R:K28	20.96	No	No	1	3	5
1155	R:R:G30	R:R:K29	3.49	No	No	0	9	3
1156	R:R:G30	R:R:T92	1.82	No	No	0	9	7
1157	R:R:G30	R:R:G94	2.11	No	No	0	9	9
1158	R:R:D31	R:R:L91	4.07	No	No	0	8	6
1159	R:R:D31	R:R:T92	11.56	No	No	0	8	7
1160	R:R:I32	R:R:L93	4.28	No	Yes	0	6	9
1161	R:R:I139	R:R:I32	5.89	No	No	0	5	6
1162	R:R:I32	R:R:L431	4.28	No	No	0	6	8
1163	R:R:I33	R:R:R96	3.76	No	Yes	0	5	4
1164	R:R:I33	R:R:P136	3.39	No	No	0	5	4
1165	R:R:L34	R:R:L93	2.77	No	Yes	0	7	9
1166	R:R:I427	R:R:L34	7.14	No	No	0	5	7
1167	R:R:G35	R:R:G36	2.11	Yes	Yes	1	8	7
1168	R:R:F114	R:R:G35	4.52	Yes	Yes	1	5	8
1169	R:R:G35	R:R:T138	1.82	Yes	No	1	8	6
1170	R:R:G35	R:R:V141	3.68	Yes	Yes	1	8	7
1171	R:R:F38	R:R:G36	3.01	Yes	Yes	1	7	7
1172	R:R:G36	R:R:M74	3.49	Yes	Yes	1	7	8
1173	R:R:G36	R:R:I97	3.53	Yes	Yes	1	7	8
1174	R:R:G36	R:R:V142	1.84	Yes	No	1	7	7
1175	R:R:L37	R:R:T100	4.42	No	No	0	6	7
1176	R:R:F114	R:R:L37	4.87	Yes	No	0	5	6
1177	R:R:L37	R:R:V153	4.47	No	Yes	0	6	6
1178	R:R:F38	R:R:W70	2	Yes	Yes	1	7	5
1179	R:R:F38	R:R:L71	3.65	Yes	Yes	1	7	4
1180	R:R:F38	R:R:M74	7.46	Yes	Yes	1	7	8
1181	R:R:F38	R:R:I97	2.51	Yes	Yes	1	7	8
1182	R:R:F38	R:R:Y167	13.41	Yes	Yes	1	7	8
1183	R:R:F38	R:R:V420	5.24	Yes	Yes	1	7	7
1184	R:R:N64	R:R:P39	3.26	Yes	Yes	1	4	6
1185	R:R:G67	R:R:P39	2.03	No	Yes	1	4	6
1186	R:R:P39	R:R:W70	5.4	Yes	Yes	1	6	5
1187	R:R:N102	R:R:P39	4.89	No	Yes	0	3	6
1188	R:R:P39	R:R:T145	8.74	Yes	Yes	1	6	5
1189	R:R:H41	R:R:I40	6.63	Yes	Yes	1	7	5
1190	R:R:I40	R:R:Y63	6.04	Yes	Yes	1	5	5
1191	R:R:F68	R:R:I40	2.51	Yes	Yes	1	7	5
1192	R:R:D99	R:R:I40	11.2	Yes	Yes	1	9	5
1193	R:R:F347	R:R:I40	3.77	Yes	Yes	1	5	5
1194	R:R:C60	R:R:H41	13.27	No	Yes	1	7	7
1195	R:R:H41	R:R:Y63	5.44	Yes	Yes	1	7	5
1196	R:R:D99	R:R:H41	5.04	Yes	Yes	1	9	7
1197	R:R:C101	R:R:H41	5.9	Yes	Yes	1	8	7
1198	R:R:E350	R:R:H41	8.62	Yes	Yes	1	5	7
1199	R:R:F42	R:R:R62	5.34	Yes	No	1	3	4
1200	R:R:F42	R:R:N64	20.54	Yes	Yes	1	3	4
1201	R:R:F42	R:R:P274	4.33	Yes	Yes	1	3	3
1202	R:R:F42	R:R:L304	15.83	Yes	Yes	1	3	2
1203	R:R:V44	R:R:V58	6.41	No	No	0	2	1
1204	R:R:T103	R:R:V44	6.35	No	No	0	4	2
1205	R:R:A45	R:R:K47	3.21	No	No	0	1	2
1206	R:R:K47	R:R:Q49	12.2	No	No	0	2	1
1207	R:R:E59	R:R:K47	13.5	No	No	0	1	2
1208	R:R:D50	R:R:K52	20.74	No	No	0	3	3
1209	R:R:L51	R:R:P55	3.28	Yes	Yes	11	6	6
1210	R:R:K52	R:R:S53	3.06	No	No	0	3	3
1211	R:R:P55	R:R:R54	2.88	Yes	No	11	6	2
1212	R:R:K106	R:R:V58	3.04	Yes	No	0	4	1
1213	R:R:C101	R:R:C60	7.28	Yes	No	1	8	7
1214	R:R:C60	R:R:K106	3.23	No	Yes	1	7	4
1215	R:R:E277	R:R:R62	3.49	Yes	No	1	2	4
1216	R:R:L304	R:R:R62	2.43	Yes	No	1	2	4
1217	R:R:F65	R:R:Y63	8.25	Yes	Yes	1	2	5
1218	R:R:F68	R:R:Y63	6.19	Yes	Yes	1	7	5
1219	R:R:E350	R:R:Y63	8.98	Yes	Yes	1	5	5
1220	R:R:F351	R:R:Y63	6.19	Yes	Yes	1	6	5
1221	R:R:E354	R:R:Y63	14.59	No	Yes	1	4	5
1222	R:R:N64	R:R:R66	3.62	Yes	Yes	1	4	5
1223	R:R:G67	R:R:N64	5.09	No	Yes	1	4	4
1224	R:R:F351	R:R:F65	4.29	Yes	Yes	1	6	2
1225	R:R:F65	R:R:T406	15.56	Yes	No	0	2	4
1226	R:R:F65	R:R:P407	7.22	Yes	No	0	2	1
1227	R:R:F65	R:R:Y408	2.06	Yes	Yes	1	2	3
1228	R:R:R66	R:R:R69	5.33	Yes	Yes	1	5	8
1229	R:R:R66	R:R:W70	7	Yes	Yes	1	5	5
1230	R:R:R66	W:W:W1	4	Yes	Yes	1	5	0
1231	R:R:R66	W:W:?2	26.55	Yes	Yes	1	5	0
1232	R:R:G67	R:R:W70	5.63	No	Yes	1	4	5
1233	R:R:F68	R:R:Q72	11.71	Yes	Yes	1	7	7
1234	R:R:F68	R:R:N345	6.04	Yes	Yes	1	7	8
1235	R:R:F347	R:R:F68	2.14	Yes	Yes	1	5	7
1236	R:R:F351	R:R:F68	11.79	Yes	Yes	1	6	7
1237	R:R:F68	R:R:Y408	8.25	Yes	Yes	1	7	3
1238	R:R:F330	R:R:R69	2.14	Yes	Yes	1	8	8
1239	R:R:L334	R:R:R69	4.86	Yes	Yes	1	6	8
1240	R:R:R69	R:R:Y408	2.06	Yes	Yes	1	8	3
1241	R:R:R69	R:R:Y411	11.32	Yes	Yes	1	8	5
1242	R:R:L414	R:R:R69	2.43	Yes	Yes	1	6	8
1243	R:R:R69	R:R:S417	6.59	Yes	Yes	1	8	6
1244	R:R:R69	W:W:?2	16.77	Yes	Yes	1	8	0
1245	R:R:T145	R:R:W70	7.28	Yes	Yes	1	5	5
1246	R:R:W70	R:R:Y167	3.86	Yes	Yes	1	5	8
1247	R:R:I416	R:R:W70	12.92	Yes	Yes	1	4	5
1248	R:R:S417	R:R:W70	3.71	Yes	Yes	1	6	5
1249	R:R:V420	R:R:W70	2.45	Yes	Yes	1	7	5
1250	R:R:W70	W:W:W1	4.69	Yes	Yes	1	5	0
1251	R:R:W70	W:W:?2	14.41	Yes	Yes	1	5	0
1252	R:R:I75	R:R:L71	2.85	Yes	Yes	1	4	4
1253	R:R:I97	R:R:L71	7.14	Yes	Yes	1	8	4
1254	R:R:L71	R:R:N345	4.12	Yes	Yes	1	4	8
1255	R:R:F347	R:R:L71	2.44	Yes	Yes	1	5	4
1256	R:R:F333	R:R:Q72	8.2	Yes	Yes	1	7	7
1257	R:R:L334	R:R:Q72	2.66	Yes	Yes	1	6	7
1258	R:R:N345	R:R:Q72	3.96	Yes	Yes	1	8	7
1259	R:R:Q72	R:R:Y408	6.76	Yes	Yes	1	7	3
1260	R:R:A73	R:R:F330	4.16	No	Yes	0	7	8
1261	R:R:A73	R:R:V420	3.39	No	Yes	0	7	7
1262	R:R:I78	R:R:M74	2.92	No	Yes	0	6	8
1263	R:R:I97	R:R:M74	7.29	Yes	Yes	1	8	8
1264	R:R:M74	R:R:V142	4.56	Yes	No	1	8	7
1265	R:R:M74	R:R:V424	3.04	Yes	No	0	8	8
1266	R:R:I75	R:R:Y95	10.88	Yes	Yes	1	4	8
1267	R:R:I75	R:R:I97	2.94	Yes	Yes	1	4	8
1268	R:R:F333	R:R:I75	5.02	Yes	Yes	1	7	4
1269	R:R:I75	R:R:N345	2.83	Yes	Yes	1	4	8
1270	R:R:E80	R:R:F76	5.83	No	Yes	1	8	7
1271	R:R:F76	R:R:I327	2.51	Yes	Yes	1	7	6
1272	R:R:F330	R:R:F76	6.43	Yes	Yes	1	8	7
1273	R:R:F333	R:R:F76	12.86	Yes	Yes	1	7	7
1274	R:R:F76	R:R:Y421	2.06	Yes	Yes	1	7	8
1275	R:R:A77	R:R:Y421	4	No	Yes	0	8	8
1276	R:R:A77	R:R:V424	5.09	No	No	0	8	8
1277	R:R:I78	R:R:Y95	7.25	No	Yes	0	6	8
1278	R:R:E80	R:R:Y421	10.1	No	Yes	1	8	8
1279	R:R:E80	R:R:Y425	10.1	No	No	1	8	8
1280	R:R:I81	R:R:L93	5.71	No	Yes	0	9	9
1281	R:R:I81	R:R:Y425	4.84	No	No	0	9	8
1282	R:R:A428	R:R:I81	4.87	No	No	0	9	9
1283	R:R:N82	R:R:T92	4.39	No	No	0	9	7
1284	R:R:L93	R:R:N82	5.49	Yes	No	0	9	9
1285	R:R:P85	R:R:S84	3.56	No	No	0	3	6
1286	R:R:P85	W:W:?3	3.02	No	Yes	0	3	0
1287	R:R:H429	R:R:L87	10.29	No	No	0	6	6
1288	R:R:L87	R:R:Q432	2.66	No	Yes	0	6	7
1289	R:R:L87	W:W:?3	2.54	No	Yes	0	6	0
1290	R:R:L88	R:R:L91	9.69	Yes	No	0	9	6
1291	R:R:L88	R:R:L93	2.77	Yes	Yes	0	9	9
1292	R:R:L431	R:R:L88	4.15	No	Yes	0	8	9
1293	R:R:L88	R:R:Q432	2.66	Yes	Yes	0	9	7
1294	R:R:L88	W:W:?3	2.54	Yes	Yes	0	9	0
1295	R:R:P89	R:R:Y435	8.34	No	Yes	0	8	3
1296	R:R:P89	W:W:?3	9.05	No	Yes	0	8	0
1297	R:R:I97	R:R:Y95	8.46	Yes	Yes	1	8	8
1298	R:R:H344	R:R:Y95	3.27	No	Yes	1	3	8
1299	R:R:F98	R:R:R96	6.41	Yes	Yes	1	4	4
1300	R:R:R96	R:R:S113	5.27	Yes	No	1	4	4
1301	R:R:F114	R:R:R96	4.28	Yes	Yes	1	5	4
1302	R:R:A110	R:R:F98	5.55	No	Yes	0	5	4
1303	R:R:F98	R:R:S113	5.28	Yes	No	1	4	4
1304	R:R:F114	R:R:F98	6.43	Yes	Yes	1	5	4
1305	R:R:C101	R:R:D99	6.22	Yes	Yes	1	8	9
1306	R:R:D99	R:R:F347	4.78	Yes	Yes	1	9	5
1307	R:R:A107	R:R:T100	3.36	No	No	0	7	7
1308	R:R:C101	R:R:K106	3.23	Yes	Yes	1	8	4
1309	R:R:S105	R:R:T103	3.2	No	No	0	4	4
1310	R:R:K106	R:R:T103	3	Yes	No	0	4	4
1311	R:R:A152	R:R:V104	3.39	No	No	2	5	4
1312	R:R:T111	R:R:V153	7.93	No	Yes	1	7	6
1313	R:R:L156	R:R:T111	5.9	No	No	0	5	7
1314	R:R:L157	R:R:T111	2.95	Yes	No	1	7	7
1315	R:R:K119	R:R:L112	4.23	Yes	Yes	1	3	5
1316	R:R:L112	R:R:L156	2.77	Yes	No	0	5	5
1317	R:R:F114	R:R:T138	5.19	Yes	No	1	5	6
1318	R:R:F114	R:R:V141	5.24	Yes	Yes	1	5	7
1319	R:R:F160	R:R:V115	7.87	Yes	No	0	7	5
1320	R:R:N118	R:R:Q117	2.64	Yes	Yes	1	4	6
1321	R:R:I120	R:R:Q117	4.12	No	Yes	0	3	6
1322	R:R:D121	R:R:Q117	10.44	No	Yes	0	3	6
1323	R:R:Q117	R:R:S137	4.33	Yes	No	1	6	4
1324	R:R:N118	R:R:S137	5.96	Yes	No	1	4	4
1325	R:R:F160	R:R:N118	7.25	Yes	Yes	1	7	4
1326	R:R:I162	R:R:N118	4.25	Yes	Yes	1	6	4
1327	R:R:F160	R:R:K119	3.72	Yes	Yes	1	7	3
1328	R:R:I120	R:R:L125	4.28	No	Yes	0	3	4
1329	R:R:L123	R:R:L125	4.15	No	Yes	0	5	4
1330	R:R:C131	R:R:E133	4.56	No	No	0	3	5
1331	R:R:I135	R:R:S132	6.19	No	No	0	4	4
1332	R:R:E133	R:R:H134	2.46	No	No	0	5	4
1333	R:R:I135	R:R:P136	3.39	No	No	0	4	4
1334	R:R:I139	R:R:V460	4.61	No	No	0	5	7
1335	R:R:A140	R:R:P163	5.61	No	Yes	0	6	8
1336	R:R:A140	R:R:I427	4.87	No	No	0	6	5
1337	R:R:G143	R:R:V141	1.84	No	Yes	0	9	7
1338	R:R:L157	R:R:V141	5.96	Yes	Yes	1	7	7
1339	R:R:V142	R:R:Y167	2.52	No	Yes	1	7	8
1340	R:R:G143	R:R:Q164	4.93	No	Yes	0	9	8
1341	R:R:G143	R:R:S166	3.71	No	Yes	0	9	9
1342	R:R:A144	R:R:V149	5.09	No	No	0	6	4
1343	R:R:A144	R:R:S150	3.42	No	Yes	0	6	8
1344	R:R:G146	R:R:T145	3.64	No	Yes	0	5	5
1345	R:R:T145	R:R:Y167	7.49	Yes	Yes	1	5	8
1346	R:R:A168	R:R:T145	5.03	No	Yes	1	5	5
1347	R:R:T145	W:W:W1	6.06	Yes	Yes	1	5	0
1348	R:R:G146	R:R:V149	1.84	No	No	0	5	4
1349	R:R:G148	R:R:S147	1.86	No	No	0	4	8
1350	R:R:S147	R:R:S171	4.89	No	No	0	8	7
1351	R:R:S147	R:R:Y218	5.09	No	Yes	0	8	7
1352	R:R:G148	R:R:T151	1.82	No	Yes	0	4	5
1353	R:R:Q164	R:R:S150	2.89	Yes	Yes	1	8	8
1354	R:R:S150	R:R:S166	3.26	Yes	Yes	1	8	9
1355	R:R:S150	R:R:S169	6.52	Yes	No	1	8	8
1356	R:R:L174	R:R:T151	4.42	Yes	Yes	1	7	5
1357	R:R:F180	R:R:T151	6.49	Yes	Yes	1	5	5
1358	R:R:D217	R:R:T151	4.34	No	Yes	0	6	5
1359	R:R:L157	R:R:V153	2.98	Yes	Yes	1	7	6
1360	R:R:Q164	R:R:V153	4.3	Yes	Yes	1	8	6
1361	R:R:A154	R:R:Q164	3.03	No	Yes	0	7	8
1362	R:R:A154	R:R:F180	2.77	No	Yes	0	7	5
1363	R:R:N155	R:R:Q179	5.28	Yes	Yes	1	5	5
1364	R:R:F180	R:R:N155	4.83	Yes	Yes	1	5	5
1365	R:R:I162	R:R:L157	4.28	Yes	Yes	1	6	7
1366	R:R:L157	R:R:Q164	5.32	Yes	Yes	1	7	8
1367	R:R:G158	R:R:S182	3.71	No	No	0	6	7
1368	R:R:F160	R:R:L159	3.65	Yes	No	0	7	5
1369	R:R:F160	R:R:I162	2.51	Yes	Yes	1	7	6
1370	R:R:K181	R:R:Y161	7.17	No	No	0	7	4
1371	R:R:L461	R:R:Y161	2.34	Yes	No	0	7	4
1372	R:R:I162	R:R:P163	3.39	Yes	Yes	1	6	8
1373	R:R:A457	R:R:I162	4.87	No	Yes	1	4	6
1374	R:R:A457	R:R:P163	1.87	No	Yes	1	4	8
1375	R:R:P163	R:R:V460	3.53	Yes	No	0	8	7
1376	R:R:L461	R:R:P163	6.57	Yes	Yes	0	7	8
1377	R:R:L464	R:R:P163	3.28	Yes	Yes	0	7	8
1378	R:R:F183	R:R:Q164	10.54	Yes	Yes	1	8	8
1379	R:R:A423	R:R:V165	3.39	No	No	0	9	6
1380	R:R:I427	R:R:V165	4.61	No	No	0	5	6
1381	R:R:S166	R:R:S169	6.52	Yes	No	1	9	8
1382	R:R:F183	R:R:S166	3.96	Yes	Yes	1	8	9
1383	R:R:A168	R:R:Y167	2.67	No	Yes	1	5	8
1384	R:R:I416	R:R:Y167	4.84	Yes	Yes	1	4	8
1385	R:R:V420	R:R:Y167	8.83	Yes	Yes	1	7	8
1386	R:R:A168	W:W:W1	5.19	No	Yes	1	5	0
1387	R:R:I187	R:R:S170	4.64	Yes	No	1	6	7
1388	R:R:D190	R:R:S170	7.36	Yes	No	1	8	7
1389	R:R:S170	R:R:Y218	2.54	No	Yes	1	7	7
1390	R:R:L173	R:R:S171	4.5	Yes	No	2	5	7
1391	R:R:P221	R:R:S171	3.56	Yes	No	2	3	7
1392	R:R:L173	R:R:R172	6.07	Yes	Yes	2	5	4
1393	R:R:E191	R:R:R172	8.14	No	Yes	0	3	4
1394	R:R:P221	R:R:R172	2.88	Yes	Yes	2	3	4
1395	R:R:D217	R:R:L173	5.43	No	Yes	0	6	5
1396	R:R:L173	R:R:P221	8.21	Yes	Yes	2	5	3
1397	R:R:F180	R:R:L174	3.65	Yes	Yes	1	5	7
1398	R:R:F183	R:R:L174	18.27	Yes	Yes	1	8	7
1399	R:R:L174	R:R:R185	4.86	Yes	Yes	1	7	9
1400	R:R:R185	R:R:S175	5.27	Yes	No	1	9	8
1401	R:R:C482	R:R:S175	6.89	No	No	1	7	8
1402	R:R:D484	R:R:S175	5.89	Yes	No	1	8	8
1403	R:R:N176	R:R:N178	8.17	No	No	0	6	3
1404	R:R:N176	R:R:Q179	6.6	No	Yes	0	6	5
1405	R:R:F183	R:R:K177	3.72	Yes	No	0	8	7
1406	R:R:F180	R:R:Q179	10.54	Yes	Yes	1	5	5
1407	R:R:L461	R:R:S182	4.5	Yes	No	0	7	7
1408	R:R:F183	R:R:R185	6.41	Yes	Yes	1	8	9
1409	R:R:L184	R:R:L464	4.15	No	Yes	0	6	7
1410	R:R:I187	R:R:R185	2.51	Yes	Yes	1	6	9
1411	R:R:N189	R:R:R185	6.03	No	Yes	1	8	9
1412	R:R:D484	R:R:R185	5.96	Yes	Yes	1	8	9
1413	R:R:N419	R:R:T186	2.92	Yes	No	0	7	8
1414	R:R:L422	R:R:T186	4.42	No	No	0	8	8
1415	R:R:I187	R:R:P188	3.39	Yes	No	0	6	8
1416	R:R:I187	R:R:L322	5.71	Yes	Yes	1	6	4
1417	R:R:I187	R:R:N419	5.66	Yes	Yes	1	6	7
1418	R:R:G487	R:R:P188	2.03	No	No	0	6	8
1419	R:R:E191	R:R:N189	7.89	No	No	0	3	8
1420	R:R:D484	R:R:N189	4.04	Yes	No	1	8	8
1421	R:R:D190	R:R:Q193	2.61	Yes	Yes	1	8	9
1422	R:R:D190	R:R:Y218	9.2	Yes	Yes	1	8	7
1423	R:R:D190	R:R:F270	3.58	Yes	Yes	1	8	7
1424	R:R:E191	R:R:K225	14.85	No	Yes	0	3	3
1425	R:R:H192	R:R:Y489	3.27	No	Yes	1	4	8
1426	R:R:H192	R:R:Y511	2.18	No	Yes	1	4	5
1427	R:R:H192	R:R:V513	8.3	No	Yes	1	4	3
1428	R:R:F270	R:R:Q193	2.34	Yes	Yes	1	7	9
1429	R:R:Q193	R:R:S296	2.89	Yes	Yes	1	9	8
1430	R:R:E297	R:R:Q193	5.1	No	Yes	0	8	9
1431	R:R:F320	R:R:Q193	7.03	Yes	Yes	1	6	9
1432	R:R:Q193	R:R:Y489	4.51	Yes	Yes	1	9	8
1433	R:R:A194	R:R:K225	3.21	No	Yes	0	7	3
1434	R:R:D199	R:R:T195	2.89	Yes	Yes	1	7	4
1435	R:R:E229	R:R:T195	12.7	Yes	Yes	1	5	4
1436	R:R:T195	R:R:Y511	2.5	Yes	Yes	1	4	5
1437	R:R:K517	R:R:T195	3	Yes	Yes	1	1	4
1438	R:R:A196	R:R:F320	4.16	No	Yes	0	8	6
1439	R:R:A196	R:R:Y511	10.68	No	Yes	0	8	5
1440	R:R:F226	R:R:M197	2.49	Yes	Yes	1	6	7
1441	R:R:M197	R:R:V268	4.56	Yes	Yes	1	7	6
1442	R:R:F270	R:R:M197	7.46	Yes	Yes	1	7	7
1443	R:R:F320	R:R:M197	6.22	Yes	Yes	1	6	7
1444	R:R:A198	R:R:F226	2.77	No	Yes	1	7	6
1445	R:R:A198	R:R:E229	3.02	No	Yes	1	7	5
1446	R:R:A198	R:R:R233	5.53	No	Yes	1	7	4
1447	R:R:D199	R:R:R233	10.72	Yes	Yes	1	7	4
1448	R:R:D199	R:R:Y511	4.6	Yes	Yes	1	7	5
1449	R:R:D199	R:R:K517	5.53	Yes	Yes	1	7	1
1450	R:R:D199	R:R:L521	4.07	Yes	Yes	1	7	5
1451	R:R:F204	R:R:I200	2.51	Yes	Yes	1	7	8
1452	R:R:F320	R:R:I200	2.51	Yes	Yes	1	6	8
1453	R:R:I200	R:R:I491	5.89	Yes	Yes	1	8	8
1454	R:R:I200	R:R:L521	2.85	Yes	Yes	1	8	5
1455	R:R:I201	R:R:W206	2.35	Yes	Yes	1	6	9
1456	R:R:I201	R:R:V209	6.14	Yes	Yes	1	6	8
1457	R:R:F226	R:R:I201	2.51	Yes	Yes	1	6	6
1458	R:R:I201	R:R:I235	5.89	Yes	Yes	1	6	7
1459	R:R:I201	R:R:L294	2.85	Yes	Yes	0	6	7
1460	R:R:E202	R:R:R233	9.3	No	Yes	0	5	4
1461	R:R:F204	R:R:Y203	9.28	Yes	No	1	7	5
1462	R:R:L521	R:R:Y203	3.52	Yes	No	1	5	5
1463	R:R:I523	R:R:Y203	7.25	Yes	No	1	6	5
1464	R:R:F204	R:R:W206	13.03	Yes	Yes	1	7	9
1465	R:R:F204	R:R:I523	3.77	Yes	Yes	1	7	6
1466	R:R:E525	R:R:F204	3.5	Yes	Yes	1	4	7
1467	R:R:F204	R:R:W530	12.03	Yes	Yes	1	7	8
1468	H:H:?3	R:R:R205	8.67	Yes	No	1	0	4
1469	H:H:?4	R:R:R205	19.51	No	No	1	0	4
1470	R:R:V266	R:R:W206	7.36	Yes	Yes	1	7	9
1471	R:R:W206	R:R:W530	3.75	Yes	Yes	1	9	8
1472	R:R:V537	R:R:W206	2.45	Yes	Yes	1	4	9
1473	R:R:P538	R:R:W206	2.7	Yes	Yes	1	8	9
1474	R:R:S540	R:R:W206	11.12	No	Yes	1	9	9
1475	R:R:N207	R:R:N541	12.26	No	Yes	1	6	5
1476	R:R:C561	R:R:N207	7.87	Yes	No	1	9	6
1477	H:H:?3	R:R:N207	15.92	Yes	No	1	0	6
1478	R:R:C236	R:R:W208	2.61	Yes	Yes	1	9	9
1479	R:R:D238	R:R:W208	20.1	Yes	Yes	1	8	9
1480	R:R:T263	R:R:W208	2.43	No	Yes	0	5	9
1481	R:R:A264	R:R:W208	3.89	No	Yes	1	7	9
1482	R:R:C542	R:R:W208	20.89	No	Yes	1	9	9
1483	R:R:P559	R:R:W208	8.11	No	Yes	1	6	9
1484	R:R:C562	R:R:W208	7.84	No	Yes	1	9	9
1485	R:R:G210	R:R:V209	3.68	No	Yes	0	8	8
1486	R:R:I235	R:R:V209	3.07	Yes	Yes	1	7	8
1487	R:R:I237	R:R:V209	3.07	Yes	Yes	1	6	8
1488	R:R:V209	R:R:V266	3.21	Yes	Yes	1	8	7
1489	R:R:F239	R:R:G210	9.03	Yes	No	0	6	8
1490	R:R:I223	R:R:T211	6.08	No	Yes	0	5	5
1491	R:R:F226	R:R:T211	2.59	Yes	Yes	1	6	5
1492	R:R:I237	R:R:T211	9.12	Yes	Yes	1	6	5
1493	R:R:S240	R:R:T211	6.4	No	Yes	0	4	5
1494	R:R:T211	R:R:V268	3.17	Yes	Yes	1	5	6
1495	R:R:F239	R:R:I212	3.77	Yes	No	1	6	6
1496	R:R:I212	R:R:I243	4.42	No	Yes	1	6	5
1497	R:R:I212	R:R:I259	2.94	No	Yes	1	6	6
1498	R:R:A213	R:R:G219	1.95	No	No	0	4	7
1499	R:R:A213	R:R:I223	4.87	No	No	0	4	5
1500	R:R:A214	R:R:D216	3.09	No	No	1	5	6
1501	R:R:A214	R:R:S271	3.42	No	No	0	5	4
1502	R:R:A214	R:R:D275	4.63	No	Yes	1	5	5
1503	R:R:D215	R:R:R220	7.15	Yes	Yes	2	6	6
1504	R:R:D215	R:R:L242	8.14	Yes	No	2	6	4
1505	R:R:D216	R:R:Y218	3.45	No	Yes	1	6	7
1506	R:R:D216	R:R:D275	2.66	No	Yes	1	6	5
1507	R:R:D217	R:R:R220	3.57	No	Yes	0	6	6
1508	R:R:G219	R:R:Y218	4.35	No	Yes	0	7	7
1509	R:R:F270	R:R:Y218	2.06	Yes	Yes	1	7	7
1510	R:R:S296	R:R:Y218	6.36	Yes	Yes	1	8	7
1511	R:R:A298	R:R:Y218	4	No	Yes	1	6	7
1512	R:R:Y218	W:W:W1	1.93	Yes	Yes	1	7	0
1513	R:R:L242	R:R:R220	2.43	No	Yes	2	4	6
1514	R:R:G222	R:R:P221	2.03	No	Yes	0	7	3
1515	R:R:F270	R:R:G222	4.52	Yes	No	0	7	7
1516	R:R:F270	R:R:I223	6.28	Yes	No	0	7	5
1517	R:R:E224	R:R:R227	12.79	No	Yes	0	6	4
1518	R:R:E228	R:R:K225	4.05	No	Yes	0	3	3
1519	R:R:E229	R:R:K225	13.5	Yes	Yes	0	5	3
1520	R:R:A230	R:R:F226	2.77	No	Yes	0	6	6
1521	R:R:F226	R:R:I237	2.51	Yes	Yes	1	6	6
1522	R:R:F226	R:R:V268	10.49	Yes	Yes	1	6	6
1523	R:R:E231	R:R:R227	8.14	No	Yes	0	4	4
1524	R:R:I237	R:R:R227	2.51	Yes	Yes	0	6	4
1525	R:R:E229	R:R:R233	3.49	Yes	Yes	1	5	4
1526	R:R:A230	R:R:I235	4.87	No	Yes	0	6	7
1527	R:R:I235	R:R:R233	3.76	Yes	Yes	1	7	4
1528	R:R:K517	R:R:R233	3.71	Yes	Yes	1	1	4
1529	I:I:?2	R:R:D234	7.48	No	No	41	0	5
1530	R:R:C236	R:R:P559	3.77	Yes	No	1	9	6
1531	R:R:C236	R:R:C561	7.28	Yes	Yes	1	9	9
1532	R:R:D238	R:R:F239	3.58	Yes	Yes	1	8	6
1533	R:R:D238	R:R:S262	7.36	Yes	No	1	8	7
1534	R:R:A264	R:R:D238	3.09	No	Yes	1	7	8
1535	R:R:F239	R:R:V258	2.62	Yes	No	0	6	4
1536	R:R:F239	R:R:I259	3.77	Yes	Yes	1	6	6
1537	R:R:F239	R:R:S262	5.28	Yes	No	1	6	7
1538	R:R:F239	R:R:I267	3.77	Yes	Yes	1	6	7
1539	R:R:E241	R:R:H254	8.62	No	No	0	5	3
1540	R:R:E241	R:R:V255	7.13	No	Yes	0	5	5
1541	R:R:E241	R:R:V258	4.28	No	No	0	5	4
1542	R:R:I243	R:R:V255	3.07	Yes	Yes	1	5	5
1543	R:R:I243	R:R:S271	3.1	Yes	No	0	5	4
1544	R:R:I243	R:R:L279	5.71	Yes	Yes	1	5	5
1545	R:R:Q245	R:R:Y246	11.27	Yes	No	0	4	3
1546	R:R:P274	R:R:Q245	4.74	Yes	Yes	0	3	4
1547	R:R:D275	R:R:Q245	2.61	Yes	Yes	0	5	4
1548	R:R:E251	R:R:S247	2.87	No	No	0	4	2
1549	R:R:D248	R:R:E249	3.9	No	No	48	3	2
1550	R:R:D248	R:R:E250	12.99	No	No	48	3	2
1551	R:R:D248	R:R:E251	14.29	No	No	0	3	4
1552	R:R:E249	R:R:E250	7.61	No	No	48	2	2
1553	R:R:I252	R:R:L279	4.28	No	Yes	0	4	5
1554	R:R:E257	R:R:Q253	2.55	No	No	0	3	3
1555	R:R:E282	R:R:Q253	6.37	Yes	No	20	6	3
1556	R:R:Q253	R:R:R286	11.68	No	Yes	20	3	4
1557	H:H:?9	R:R:H254	2.29	No	No	0	0	3
1558	R:R:I259	R:R:V255	3.07	Yes	Yes	1	6	5
1559	R:R:L279	R:R:V255	5.96	Yes	Yes	1	5	5
1560	R:R:E282	R:R:V256	4.28	Yes	No	20	6	5
1561	R:R:I283	R:R:V256	4.61	No	No	0	4	5
1562	R:R:R286	R:R:V256	5.23	Yes	No	20	4	5
1563	H:H:?9	R:R:E257	5.91	No	No	0	0	3
1564	R:R:I259	R:R:I267	2.94	Yes	Yes	1	6	7
1565	R:R:Q260	R:R:R286	8.18	No	Yes	20	5	4
1566	R:R:I288	R:R:Q260	6.86	No	No	20	4	5
1567	H:H:?9	R:R:N261	24.5	No	No	0	0	4
1568	R:R:I292	R:R:K265	2.91	Yes	No	0	7	5
1569	R:R:F539	R:R:K265	2.48	Yes	No	0	1	5
1570	R:R:K265	R:R:S540	3.06	No	No	0	5	9
1571	R:R:I292	R:R:V266	6.14	Yes	Yes	1	7	7
1572	R:R:L294	R:R:V266	2.98	Yes	Yes	0	7	7
1573	R:R:S540	R:R:V266	3.23	No	Yes	1	9	7
1574	R:R:I267	R:R:K291	4.36	Yes	No	1	7	6
1575	R:R:I267	R:R:W293	7.05	Yes	Yes	1	7	8
1576	R:R:L294	R:R:V268	4.47	Yes	Yes	0	7	6
1577	R:R:L276	R:R:V269	2.98	Yes	No	1	5	5
1578	R:R:V269	R:R:W293	2.45	No	Yes	1	5	8
1579	R:R:V269	R:R:W299	9.81	No	Yes	1	5	7
1580	R:R:F270	R:R:S296	5.28	Yes	Yes	1	7	8
1581	R:R:L276	R:R:S271	3	Yes	No	0	5	4
1582	R:R:G273	R:R:S272	1.86	No	No	0	4	5
1583	R:R:D275	R:R:S272	7.36	Yes	No	0	5	5
1584	R:R:S272	W:W:W1	3.71	No	Yes	0	5	0
1585	R:R:G273	R:R:P274	4.06	No	Yes	0	4	3
1586	R:R:G273	R:R:S302	3.71	No	No	0	4	5
1587	R:R:L304	R:R:P274	3.28	Yes	Yes	1	2	3
1588	R:R:L276	R:R:L279	2.77	Yes	Yes	1	5	5
1589	R:R:L276	R:R:W299	10.25	Yes	Yes	1	5	7
1590	R:R:I305	R:R:L276	4.28	Yes	Yes	1	4	5
1591	R:R:E277	R:R:P278	3.14	Yes	No	0	2	2
1592	R:R:E277	R:R:K281	5.4	Yes	No	0	2	2
1593	R:R:E277	R:R:L304	6.63	Yes	Yes	1	2	2
1594	R:R:I280	R:R:I305	4.42	No	Yes	1	5	4
1595	R:R:I280	R:R:Y310	2.42	No	Yes	1	5	3
1596	R:R:I280	R:R:V314	3.07	No	Yes	1	5	7
1597	R:R:K281	R:R:Y310	4.78	No	Yes	0	2	3
1598	R:R:E282	R:R:R285	8.14	Yes	No	20	6	3
1599	R:R:E282	R:R:R286	3.49	Yes	Yes	20	6	4
1600	R:R:I283	R:R:I288	7.36	No	No	0	4	4
1601	R:R:I283	R:R:V313	4.61	No	Yes	0	4	3
1602	R:R:V284	R:R:Y310	10.09	No	Yes	1	3	3
1603	R:R:H312	R:R:V284	8.3	No	No	1	3	3
1604	R:R:V284	R:R:V313	6.41	No	Yes	1	3	3
1605	R:R:R285	R:R:R286	3.2	No	Yes	20	3	4
1606	R:R:I288	R:R:R286	2.51	No	Yes	20	4	4
1607	R:R:N287	R:R:T289	4.39	No	No	0	6	5
1608	R:R:H312	R:R:N287	5.1	No	No	0	3	6
1609	H:H:?10	R:R:N287	28.17	No	No	0	0	6
1610	R:R:G290	R:R:T289	3.64	No	No	0	4	5
1611	R:R:K291	R:R:W293	3.48	No	Yes	1	6	8
1612	R:R:I292	R:R:W530	2.35	Yes	Yes	1	7	8
1613	R:R:I292	R:R:P538	6.77	Yes	Yes	1	7	8
1614	R:R:W293	R:R:W299	2.81	Yes	Yes	1	8	7
1615	R:R:V313	R:R:W293	2.45	Yes	Yes	1	3	8
1616	R:R:T317	R:R:W293	7.28	No	Yes	1	7	8
1617	R:R:I318	R:R:L294	2.85	Yes	Yes	0	6	7
1618	R:R:A295	R:R:W299	10.37	No	Yes	0	7	7
1619	R:R:A295	R:R:G319	1.95	No	No	0	7	8
1620	R:R:S296	R:R:W299	2.47	Yes	Yes	1	8	7
1621	R:R:E297	R:R:L322	10.6	No	Yes	0	8	4
1622	R:R:E297	W:W:W1	5.45	No	Yes	0	8	0
1623	R:R:A298	W:W:W1	5.19	No	Yes	1	6	0
1624	R:R:I305	R:R:W299	5.87	Yes	Yes	1	4	7
1625	R:R:T317	R:R:W299	2.43	No	Yes	1	7	7
1626	R:R:W299	R:R:W494	4.69	Yes	Yes	1	7	7
1627	R:R:A300	R:R:G319	1.95	No	No	0	6	8
1628	R:R:L304	R:R:S302	3	Yes	No	0	2	5
1629	R:R:I305	R:R:W494	3.52	Yes	Yes	1	4	7
1630	R:R:A306	R:R:W494	6.48	No	Yes	1	4	7
1631	R:R:A306	R:R:I503	4.87	No	Yes	1	4	4
1632	R:R:A306	R:R:F505	2.77	No	Yes	1	4	4
1633	R:R:M307	R:R:Q309	6.8	No	No	1	3	3
1634	R:R:M307	R:R:Y310	5.99	No	Yes	1	3	3
1635	R:R:Q309	R:R:Y310	3.38	No	Yes	1	3	3
1636	R:R:V314	R:R:Y310	2.52	Yes	Yes	1	7	3
1637	R:R:F311	R:R:G315	6.02	Yes	No	1	3	4
1638	R:R:F311	R:R:L496	24.36	Yes	No	0	3	3
1639	R:R:F311	R:R:I503	5.02	Yes	Yes	1	3	4
1640	R:R:F311	R:R:G532	4.52	Yes	No	1	3	1
1641	R:R:H312	R:R:V313	5.54	No	Yes	1	3	3
1642	R:R:V313	R:R:V314	3.21	Yes	Yes	1	3	7
1643	R:R:V314	R:R:W494	4.9	Yes	Yes	1	7	7
1644	R:R:G315	R:R:G316	2.11	No	No	1	4	8
1645	R:R:G315	R:R:G532	2.11	No	No	1	4	1
1646	R:R:G316	R:R:N493	5.09	No	No	0	8	9
1647	R:R:G316	R:R:G532	2.11	No	No	1	8	1
1648	R:R:T317	R:R:W494	12.13	No	Yes	1	7	7
1649	R:R:I318	R:R:N493	2.83	Yes	No	0	6	9
1650	R:R:I318	R:R:I528	2.94	Yes	No	1	6	7
1651	R:R:I318	R:R:W530	2.35	Yes	Yes	1	6	8
1652	R:R:F320	R:R:Y489	4.13	Yes	Yes	1	6	8
1653	R:R:F320	R:R:I491	6.28	Yes	Yes	1	6	8
1654	R:R:A321	R:R:R415	6.91	No	No	0	5	5
1655	R:R:L322	R:R:N419	4.12	Yes	Yes	1	4	7
1656	R:R:L322	R:R:Y489	2.34	Yes	Yes	1	4	8
1657	R:R:E475	R:R:K323	2.7	Yes	No	1	5	5
1658	H:H:?11	R:R:K323	6.29	Yes	No	1	0	5
1659	R:R:A324	R:R:H413	4.39	No	No	0	5	7
1660	R:R:G325	R:R:Y418	10.14	No	Yes	1	4	7
1661	R:R:G325	R:R:M473	3.49	No	Yes	1	4	4
1662	R:R:M473	R:R:Q326	5.44	Yes	No	0	4	3
1663	R:R:I327	R:R:P328	3.39	Yes	No	0	6	4
1664	R:R:F330	R:R:I327	6.28	Yes	Yes	1	8	6
1665	R:R:I327	R:R:L414	4.28	Yes	Yes	1	6	6
1666	R:R:I327	R:R:Y418	3.63	Yes	Yes	1	6	7
1667	R:R:I327	R:R:Y421	12.09	Yes	Yes	1	6	8
1668	R:R:G329	R:R:P328	2.03	No	No	0	5	4
1669	R:R:F330	R:R:F333	2.14	Yes	Yes	1	8	7
1670	R:R:F330	R:R:L334	15.83	Yes	Yes	1	8	6
1671	R:R:F330	R:R:L414	6.09	Yes	Yes	1	8	6
1672	R:R:F330	R:R:S417	2.64	Yes	Yes	1	8	6
1673	R:R:E332	R:R:R331	3.49	No	Yes	0	5	4
1674	R:R:K335	R:R:R331	9.9	No	Yes	1	4	4
1675	R:R:I409	R:R:R331	12.53	Yes	Yes	1	5	4
1676	R:R:R331	R:R:Y411	8.23	Yes	Yes	1	4	5
1677	R:R:L334	R:R:Y408	11.72	Yes	Yes	1	6	3
1678	R:R:I409	R:R:L334	2.85	Yes	Yes	1	5	6
1679	R:R:L334	R:R:Y411	3.52	Yes	Yes	1	6	5
1680	R:R:I409	R:R:K335	4.36	Yes	No	1	5	4
1681	R:R:F351	R:R:V337	3.93	Yes	No	1	6	5
1682	R:R:V337	R:R:Y408	5.05	No	Yes	1	5	3
1683	R:R:H338	R:R:P339	9.15	No	No	0	4	7
1684	R:R:H338	R:R:R340	13.54	No	No	0	4	4
1685	R:R:H338	R:R:K341	6.55	No	No	0	4	3
1686	R:R:P339	R:R:W352	25.67	No	Yes	1	7	8
1687	R:R:L360	R:R:P339	3.28	Yes	No	1	4	7
1688	R:R:G397	R:R:R340	4.5	No	No	0	5	4
1689	R:R:N345	R:R:S342	2.98	Yes	No	0	8	3
1690	R:R:A348	R:R:S342	3.42	No	No	0	5	3
1691	R:R:F347	R:R:N345	3.62	Yes	Yes	1	5	8
1692	R:R:E353	R:R:K349	9.45	No	No	1	7	3
1693	R:R:K349	R:R:L360	14.1	No	Yes	1	3	4
1694	R:R:E350	R:R:E354	2.54	Yes	No	1	5	4
1695	R:R:F351	R:R:W352	3.01	Yes	Yes	1	6	8
1696	R:R:F351	R:R:T355	2.59	Yes	Yes	1	6	4
1697	R:R:F351	R:R:I401	3.77	Yes	No	1	6	7
1698	R:R:F351	R:R:Y408	11.35	Yes	Yes	1	6	3
1699	R:R:F356	R:R:W352	18.04	Yes	Yes	1	8	8
1700	R:R:L360	R:R:W352	2.28	Yes	Yes	1	4	8
1701	R:R:E399	R:R:W352	4.36	Yes	Yes	1	8	8
1702	R:R:E353	R:R:L360	7.95	No	Yes	1	7	4
1703	R:R:F356	R:R:T355	6.49	Yes	Yes	1	8	4
1704	R:R:I401	R:R:T355	4.56	No	Yes	1	7	4
1705	R:R:T355	R:R:V404	4.76	Yes	Yes	1	4	4
1706	R:R:T355	R:R:T406	3.14	Yes	No	0	4	4
1707	R:R:E399	R:R:F356	8.16	Yes	Yes	1	8	8
1708	R:R:F356	R:R:V404	3.93	Yes	Yes	1	8	4
1709	R:R:N357	R:R:R392	6.03	No	No	0	3	1
1710	R:R:C358	R:R:C395	7.28	No	No	0	9	9
1711	R:R:H359	R:R:Q361	4.95	No	No	0	4	1
1712	R:R:C395	R:R:L360	7.94	No	Yes	0	9	4
1713	R:R:G397	R:R:T396	1.82	No	No	0	5	6
1714	R:R:D398	R:R:T396	8.67	No	No	1	3	6
1715	R:R:E399	R:R:T396	12.7	Yes	No	1	8	6
1716	R:R:D398	R:R:E399	3.9	No	Yes	1	3	8
1717	R:R:N400	R:R:S402	8.94	No	No	0	4	4
1718	R:R:E405	R:R:V404	2.85	No	Yes	0	4	4
1719	R:R:I409	R:R:Y408	2.42	Yes	Yes	1	5	3
1720	R:R:L414	R:R:Y411	11.72	Yes	Yes	1	6	5
1721	R:R:H413	R:R:T412	9.58	No	No	0	7	5
1722	R:R:H413	R:R:R415	12.41	No	No	0	7	5
1723	R:R:L414	R:R:S417	6.01	Yes	Yes	1	6	6
1724	R:R:R415	W:W:?2	2.79	No	Yes	0	5	0
1725	R:R:I416	R:R:N419	2.83	Yes	Yes	1	4	7
1726	R:R:I416	W:W:W1	5.87	Yes	Yes	1	4	0
1727	R:R:I416	W:W:?2	9.85	Yes	Yes	1	4	0
1728	R:R:S417	W:W:?2	5.18	Yes	Yes	1	6	0
1729	R:R:Y418	R:R:Y421	1.99	Yes	Yes	1	7	8
1730	R:R:L422	R:R:Y418	7.03	No	Yes	1	8	7
1731	R:R:N471	R:R:Y418	4.65	Yes	Yes	1	6	7
1732	R:R:N472	R:R:Y418	4.65	No	Yes	1	4	7
1733	R:R:M473	R:R:Y418	9.58	Yes	Yes	1	4	7
1734	R:R:Y421	R:R:Y425	17.87	Yes	No	1	8	8
1735	R:R:N472	R:R:Y421	5.81	No	Yes	1	4	8
1736	R:R:L422	R:R:N471	4.12	No	Yes	1	8	6
1737	R:R:L464	R:R:S426	3	Yes	No	0	7	7
1738	R:R:L467	R:R:S426	3	No	No	0	7	7
1739	R:R:F479	R:R:S426	6.61	No	No	0	8	7
1740	R:R:F469	R:R:H429	21.5	No	No	0	8	6
1741	R:R:A430	R:R:L464	3.15	No	Yes	0	8	7
1742	R:R:L431	R:R:V460	2.98	No	No	0	8	7
1743	R:R:Q432	R:R:Y435	3.38	Yes	Yes	47	7	3
1744	R:R:Q432	R:R:T436	9.92	Yes	No	47	7	4
1745	R:R:D433	R:R:H463	8.82	No	Yes	0	4	5
1746	R:R:A450	R:R:I434	4.87	No	No	0	3	6
1747	R:R:I434	R:R:V455	3.07	No	No	0	6	4
1748	R:R:H463	R:R:I434	11.93	Yes	No	0	5	6
1749	R:R:T436	R:R:Y435	2.5	No	Yes	47	4	3
1750	R:R:I452	R:R:Y435	8.46	No	Yes	0	3	3
1751	R:R:C437	R:R:G442	1.96	No	No	49	6	4
1752	R:R:C437	R:R:C449	7.28	No	No	49	6	7
1753	R:R:L438	R:R:P439	4.93	No	No	0	3	2
1754	R:R:G440	R:R:R441	3	No	No	0	3	1
1755	R:R:G440	R:R:G447	2.11	No	No	0	3	1
1756	R:R:G442	R:R:G447	2.11	No	No	0	4	1
1757	R:R:C449	R:R:G442	1.96	No	No	49	7	4
1758	R:R:H463	R:R:L443	10.29	Yes	No	0	5	3
1759	R:R:H466	R:R:L443	5.14	Yes	No	0	4	3
1760	R:R:F444	R:R:S448	3.96	Yes	No	17	3	3
1761	R:R:A450	R:R:F444	2.77	No	Yes	17	3	3
1762	R:R:F444	R:R:Q459	4.68	Yes	Yes	17	3	7
1763	R:R:F444	R:R:H463	5.66	Yes	Yes	0	3	5
1764	R:R:A450	R:R:Q459	7.58	No	Yes	17	3	7
1765	R:R:D451	R:R:K453	13.83	No	No	50	3	2
1766	R:R:D451	R:R:K454	5.53	No	No	50	3	3
1767	R:R:K453	R:R:K454	2.87	No	No	50	2	3
1768	R:R:E456	R:R:W458	17.45	No	Yes	17	5	4
1769	R:R:E456	R:R:Q459	7.65	No	Yes	17	5	7
1770	R:R:Q459	R:R:W458	15.33	Yes	Yes	17	7	4
1771	R:R:L461	R:R:R465	6.07	Yes	Yes	0	7	5
1772	R:R:H466	R:R:K462	10.48	Yes	Yes	35	4	4
1773	R:R:H466	R:R:R465	3.39	Yes	Yes	0	4	5
1774	R:R:F469	R:R:L467	3.65	No	No	0	8	7
1775	R:R:N468	R:R:T478	5.85	No	No	0	6	3
1776	H:H:?12	R:R:N468	25.72	No	No	0	0	6
1777	R:R:F469	R:R:V477	13.11	No	No	0	8	6
1778	R:R:G474	R:R:T470	1.82	No	No	0	5	5
1779	R:R:M473	R:R:N471	2.8	Yes	Yes	1	4	6
1780	R:R:E475	R:R:N471	5.26	Yes	Yes	1	5	6
1781	R:R:N471	R:R:V477	4.43	Yes	No	0	6	6
1782	R:R:M473	R:R:N472	2.8	Yes	No	1	4	4
1783	R:R:E475	R:R:M473	2.71	Yes	Yes	1	5	4
1784	H:H:?11	R:R:E475	4.73	Yes	Yes	1	0	5
1785	R:R:Q476	R:R:T478	12.76	No	No	0	3	3
1786	R:R:F479	R:R:L485	2.44	No	No	0	8	4
1787	R:R:D480	R:R:D484	5.32	No	Yes	0	7	8
1788	R:R:C482	R:R:E481	7.6	No	No	0	7	4
1789	R:R:C482	R:R:D484	4.67	No	Yes	1	7	8
1790	R:R:G487	R:R:V486	1.84	No	No	0	6	3
1791	R:R:V486	R:R:V513	3.21	No	Yes	1	3	3
1792	R:R:V486	R:R:Y514	5.05	No	Yes	1	3	4
1793	R:R:N488	R:R:N512	5.45	No	Yes	1	4	4
1794	R:R:N488	R:R:Y514	6.98	No	Yes	1	4	4
1795	H:H:?11	R:R:N488	22.05	Yes	No	1	0	4
1796	R:R:Y489	R:R:Y511	3.97	Yes	Yes	1	8	5
1797	R:R:E507	R:R:S490	4.31	No	No	0	5	8
1798	R:R:I491	R:R:V508	3.07	Yes	No	0	8	7
1799	R:R:I491	R:R:I523	4.42	Yes	Yes	1	8	6
1800	R:R:F505	R:R:I492	6.28	Yes	No	0	4	5
1801	R:R:H495	R:R:N493	8.93	No	No	0	7	9
1802	R:R:I503	R:R:W494	4.7	Yes	Yes	1	4	7
1803	R:R:F505	R:R:W494	11.02	Yes	Yes	1	4	7
1804	R:R:H495	R:R:K506	18.34	No	No	0	7	5
1805	R:R:H495	R:R:L529	11.57	No	No	0	7	4
1806	R:R:P498	R:R:S497	3.56	No	Yes	30	3	3
1807	R:R:E499	R:R:S497	8.62	No	Yes	30	4	3
1808	R:R:D500	R:R:S497	7.36	No	Yes	30	4	3
1809	R:R:G501	R:R:S497	1.86	No	Yes	0	5	3
1810	R:R:S497	R:R:V504	3.23	Yes	No	0	3	3
1811	R:R:E499	R:R:P498	7.86	No	No	30	4	3
1812	R:R:D500	R:R:E499	10.39	No	No	30	4	4
1813	R:R:F505	R:R:I503	2.51	Yes	Yes	1	4	4
1814	R:R:E507	R:R:G509	3.27	No	No	0	5	9
1815	R:R:G509	R:R:V508	1.84	No	No	0	9	7
1816	R:R:I528	R:R:V508	9.22	No	No	0	7	7
1817	R:R:N512	R:R:Y510	2.33	Yes	No	1	4	3
1818	R:R:F522	R:R:Y510	17.54	No	No	0	1	3
1819	H:H:?11	R:R:Y510	8.37	Yes	No	1	0	3
1820	R:R:V513	R:R:Y511	2.52	Yes	Yes	1	3	5
1821	R:R:R520	R:R:Y511	13.38	No	Yes	0	3	5
1822	R:R:L521	R:R:Y511	2.34	Yes	Yes	1	5	5
1823	R:R:N512	R:R:Y514	8.14	Yes	Yes	1	4	4
1824	R:R:A515	R:R:N512	4.69	No	Yes	0	4	4
1825	H:H:?11	R:R:N512	17.15	Yes	Yes	1	0	4
1826	R:R:V513	R:R:Y514	7.57	Yes	Yes	1	3	4
1827	H:H:?11	R:R:Y514	14.64	Yes	Yes	1	0	4
1828	R:R:E519	R:R:K516	5.4	No	No	0	4	2
1829	R:R:G518	R:R:K517	5.23	No	Yes	0	3	1
1830	R:R:K517	R:R:R520	11.14	Yes	No	0	1	3
1831	R:R:I523	R:R:L521	5.71	Yes	Yes	1	6	5
1832	R:R:F522	R:R:N524	2.42	No	No	0	1	5
1833	R:R:E526	R:R:N524	10.52	No	No	0	3	5
1834	R:R:K527	R:R:N524	5.6	No	No	0	3	5
1835	R:R:E525	R:R:W530	7.63	Yes	Yes	1	4	8
1836	R:R:E525	R:R:R535	5.82	Yes	No	0	4	4
1837	R:R:E525	R:R:V537	2.85	Yes	Yes	1	4	4
1838	R:R:I528	R:R:W530	10.57	No	Yes	1	7	8
1839	R:R:V537	R:R:W530	6.13	Yes	Yes	1	4	8
1840	R:R:P538	R:R:W530	14.86	Yes	Yes	1	8	8
1841	R:R:F533	R:R:S531	3.96	No	No	0	1	4
1842	R:R:F533	R:R:S534	2.64	No	No	0	1	4
1843	R:R:E536	R:R:S534	5.75	No	No	0	5	4
1844	R:R:P538	R:R:V537	3.53	Yes	Yes	1	8	4
1845	R:R:F539	R:R:N541	8.46	Yes	Yes	1	1	5
1846	R:R:F539	R:R:R544	18.17	Yes	No	0	1	5
1847	H:H:?3	R:R:F539	5.43	Yes	Yes	1	0	1
1848	R:R:D545	R:R:N541	2.69	Yes	Yes	1	5	5
1849	H:H:?3	R:R:N541	31.85	Yes	Yes	1	0	5
1850	R:R:C542	R:R:C561	1.82	No	Yes	1	9	9
1851	R:R:C542	R:R:C562	7.28	No	No	1	9	9
1852	R:R:F563	R:R:S543	9.25	Yes	No	0	7	8
1853	R:R:D545	R:R:T577	2.89	Yes	No	0	5	5
1854	R:R:D545	R:R:D578	14.64	Yes	No	1	5	7
1855	H:H:?3	R:R:D545	3.63	Yes	Yes	1	0	5
1856	R:R:C546	R:R:T550	5.07	No	No	1	9	6
1857	R:R:C546	R:R:F563	2.79	No	Yes	1	9	7
1858	R:R:C546	R:R:C565	7.28	No	No	1	9	9
1859	R:R:A548	R:R:T596	3.36	No	No	0	4	5
1860	R:R:G549	R:R:T550	1.82	No	No	1	9	6
1861	R:R:C568	R:R:G549	1.96	Yes	No	1	9	9
1862	R:R:G549	R:R:S574	3.71	No	No	1	9	8
1863	R:R:C565	R:R:T550	3.38	No	No	1	9	6
1864	R:R:R551	R:R:V566	5.23	No	No	0	7	4
1865	R:R:C582	R:R:R551	2.79	Yes	No	0	9	7
1866	R:R:F563	R:R:K552	14.89	Yes	No	1	7	8
1867	R:R:D578	R:R:K552	6.91	No	No	1	7	8
1868	R:R:E558	R:R:I555	8.2	No	No	0	5	5
1869	R:R:E564	R:R:I555	2.73	No	No	0	6	5
1870	I:I:?1	R:R:G557	3.14	No	No	37	0	6
1871	R:R:E558	R:R:P559	3.14	No	No	0	5	6
1872	R:R:C562	R:R:E558	9.12	No	No	0	9	5
1873	R:R:D578	R:R:F563	3.58	No	Yes	1	7	7
1874	R:R:E567	R:R:V566	4.28	No	No	0	4	4
1875	R:R:C568	R:R:P569	1.88	Yes	Yes	1	9	5
1876	R:R:C568	R:R:S574	5.16	Yes	No	1	9	8
1877	R:R:C568	R:R:C582	7.28	Yes	Yes	1	9	9
1878	R:R:C568	R:R:H595	2.95	Yes	No	0	9	5
1879	R:R:E572	R:R:P569	7.86	No	Yes	1	7	5
1880	R:R:C582	R:R:P569	1.88	Yes	Yes	1	9	5
1881	R:R:G571	R:R:W590	5.63	No	Yes	16	7	6
1882	R:R:G571	R:R:S591	1.86	No	Yes	16	7	8
1883	R:R:C582	R:R:E572	3.04	Yes	No	1	9	7
1884	R:R:E572	R:R:K584	10.8	No	No	0	7	4
1885	R:R:D575	R:R:Y573	2.3	No	Yes	16	8	6
1886	R:R:N583	R:R:Y573	9.3	No	Yes	16	1	6
1887	R:R:C585	R:R:Y573	2.69	No	Yes	16	9	6
1888	R:R:C598	R:R:Y573	5.38	Yes	Yes	16	9	6
1889	R:R:D575	R:R:N583	2.69	No	No	16	8	1
1890	R:R:C585	R:R:P586	5.65	No	No	16	9	4
1891	R:R:C585	R:R:C598	7.28	No	Yes	16	9	9
1892	R:R:F589	R:R:P586	4.33	No	No	0	5	4
1893	R:R:C598	R:R:P586	1.88	Yes	No	16	9	4
1894	R:R:D587	R:R:D588	2.66	No	No	0	3	6
1895	R:R:D588	R:R:F589	2.39	No	No	0	6	5
1896	R:R:A600	R:R:F589	4.16	No	No	0	4	5
1897	R:R:S591	R:R:W590	3.71	Yes	Yes	16	8	6
1898	R:R:D758	R:R:W590	5.58	No	Yes	16	4	6
1899	R:R:E759	R:R:W590	4.36	No	Yes	16	4	6
1900	R:R:H595	R:R:S591	2.79	No	Yes	0	5	8
1901	R:R:E593	R:R:N592	3.94	No	No	31	2	7
1902	H:H:?13	R:R:N592	11.02	Yes	No	31	0	7
1903	R:R:E593	R:R:N594	6.57	No	No	31	2	3
1904	H:H:?13	R:R:E593	13	Yes	No	31	0	2
1905	H:H:?13	R:R:N594	28.17	Yes	No	31	0	3
1906	H:H:?13	R:R:T596	7.89	Yes	No	0	0	5
1907	R:R:K601	R:R:Q754	4.07	No	No	25	8	4
1908	R:R:I761	R:R:K601	2.91	Yes	No	25	7	8
1909	R:R:E602	R:R:I760	2.73	No	No	0	3	5
1910	R:R:I603	R:R:I761	2.94	No	Yes	0	4	7
1911	R:R:E604	R:R:I760	4.1	No	No	0	6	5
1912	R:R:E604	R:R:F762	4.66	No	Yes	0	6	7
1913	R:R:E604	R:R:K831	28.35	No	No	0	6	9
1914	R:R:F605	R:R:S607	9.25	Yes	No	0	7	7
1915	R:R:F605	R:R:G670	3.01	Yes	No	0	7	7
1916	R:R:E671	R:R:F605	5.83	No	Yes	0	4	7
1917	R:R:F605	R:R:I763	2.51	Yes	Yes	0	7	7
1918	R:R:I669	R:R:L606	4.28	Yes	No	0	8	9
1919	R:R:L606	R:R:S834	4.5	No	No	0	9	8
1920	R:R:S607	R:R:T609	3.2	No	No	0	7	4
1921	R:R:E610	R:R:S607	10.06	No	No	0	7	7
1922	R:R:T617	R:R:W608	3.64	Yes	Yes	21	5	5
1923	R:R:L666	R:R:W608	3.42	No	Yes	21	7	5
1924	R:R:I669	R:R:W608	8.22	Yes	Yes	21	8	5
1925	R:R:G670	R:R:W608	4.22	No	Yes	0	7	5
1926	R:R:E671	R:R:W608	2.18	No	Yes	0	4	5
1927	R:R:E610	R:R:P611	4.72	No	No	0	7	4
1928	R:R:F612	R:R:L616	2.44	No	No	0	8	8
1929	R:R:A835	R:R:F612	2.77	No	No	0	8	8
1930	R:R:I614	R:R:T617	3.04	No	Yes	0	6	5
1931	R:R:L616	R:R:V838	7.45	No	Yes	0	8	7
1932	R:R:L666	R:R:T617	2.95	No	Yes	21	7	5
1933	R:R:I669	R:R:T617	3.04	Yes	Yes	21	8	5
1934	R:R:A620	R:R:L842	3.15	No	Yes	0	7	9
1935	R:R:F662	R:R:G623	4.52	Yes	No	0	8	6
1936	R:R:I624	R:R:L659	4.28	No	No	0	5	4
1937	R:R:F662	R:R:I624	3.77	Yes	No	0	8	5
1938	R:R:F854	R:R:L626	6.09	No	No	0	4	4
1939	R:R:L659	R:R:T627	4.42	No	No	0	4	7
1940	R:R:F662	R:R:T627	2.59	Yes	No	0	8	7
1941	R:R:L849	R:R:T627	5.9	Yes	No	0	8	7
1942	R:R:F629	R:R:V630	2.62	No	Yes	4	3	7
1943	R:R:F629	R:R:V633	2.62	No	No	4	3	5
1944	R:R:F629	R:R:I857	2.51	No	Yes	4	3	8
1945	R:R:L655	R:R:V630	7.45	No	Yes	4	9	7
1946	R:R:F853	R:R:V630	3.93	Yes	Yes	4	9	7
1947	R:R:I857	R:R:V630	4.61	Yes	Yes	4	8	7
1948	R:R:I635	R:R:L631	5.71	Yes	No	4	4	4
1949	R:R:L631	R:R:Y652	3.52	No	Yes	4	4	7
1950	R:R:L631	R:R:L655	6.92	No	No	4	4	9
1951	R:R:I857	R:R:V633	4.61	Yes	No	4	8	5
1952	R:R:L861	R:R:V633	2.98	No	No	0	5	5
1953	R:R:F634	R:R:V643	3.93	Yes	No	0	9	9
1954	R:R:F634	R:R:S651	6.61	Yes	No	4	9	9
1955	R:R:F634	R:R:Y652	5.16	Yes	Yes	4	9	7
1956	R:R:F634	R:R:F853	5.36	Yes	Yes	4	9	9
1957	R:R:F634	R:R:I857	2.51	Yes	Yes	4	9	8
1958	R:R:I635	R:R:R638	3.76	Yes	No	4	4	6
1959	R:R:I635	R:R:Y652	6.04	Yes	Yes	4	4	7
1960	R:R:F637	R:R:K636	13.65	No	No	0	4	4
1961	R:R:F637	R:R:I860	2.51	No	No	0	4	9
1962	R:R:F637	R:R:L861	2.44	No	No	0	4	5
1963	R:R:R638	R:R:R648	6.4	No	Yes	0	6	8
1964	R:R:R638	R:R:Y652	4.12	No	Yes	4	6	7
1965	R:R:N639	R:R:R648	4.82	No	Yes	0	4	8
1966	R:R:P641	R:R:T640	5.25	No	No	0	8	9
1967	R:R:T640	R:R:V643	6.35	No	No	0	9	9
1968	R:R:I642	R:R:I859	2.94	No	No	0	7	9
1969	R:R:I642	R:R:I860	7.36	No	No	0	7	9
1970	R:R:I860	R:R:V643	3.07	No	No	0	9	9
1971	R:R:K644	R:R:R648	2.48	No	Yes	0	8	8
1972	A:A:N392	R:R:K644	5.6	No	No	0	7	8
1973	A:A:V394	R:R:K644	4.55	Yes	No	0	8	8
1974	R:R:A645	R:R:F801	2.77	No	Yes	0	9	9
1975	R:R:K698	R:R:T646	9.01	Yes	No	4	9	9
1976	R:R:E803	R:R:T646	4.23	Yes	No	4	9	9
1977	R:R:K856	R:R:T646	9.01	Yes	No	4	9	9
1978	R:R:L650	R:R:N647	6.87	Yes	Yes	4	8	9
1979	R:R:K698	R:R:N647	2.8	Yes	Yes	4	9	9
1980	R:R:N647	R:R:R701	14.46	Yes	Yes	4	9	8
1981	R:R:N647	R:R:Q724	9.24	Yes	Yes	4	9	8
1982	A:A:L393	R:R:N647	4.12	Yes	Yes	4	8	9
1983	R:R:E649	R:R:R648	4.65	No	Yes	0	7	8
1984	R:R:E649	R:R:Q724	8.92	No	Yes	0	7	8
1985	R:R:E649	R:R:F725	4.66	No	Yes	0	7	5
1986	R:R:L650	R:R:V697	2.98	Yes	No	4	8	8
1987	R:R:K698	R:R:L650	4.23	Yes	Yes	4	9	8
1988	R:R:L650	R:R:Q724	3.99	Yes	Yes	4	8	8
1989	R:R:F725	R:R:L650	2.44	Yes	Yes	0	5	8
1990	R:R:L650	R:R:V728	4.47	Yes	Yes	4	8	7
1991	R:R:S651	R:R:Y652	3.82	No	Yes	4	9	7
1992	R:R:C694	R:R:L653	4.76	No	No	4	6	5
1993	R:R:F725	R:R:L653	4.87	Yes	No	0	5	5
1994	R:R:L653	R:R:V728	2.98	No	Yes	4	5	7
1995	R:R:C691	R:R:L654	3.17	Yes	Yes	0	8	8
1996	R:R:C694	R:R:L654	6.35	No	Yes	0	6	8
1997	R:R:I695	R:R:L654	4.28	Yes	Yes	0	7	8
1998	R:R:F853	R:R:L654	6.09	Yes	Yes	0	9	8
1999	R:R:F853	R:R:L655	10.96	Yes	No	4	9	9
2000	R:R:C660	R:R:F656	8.38	No	No	0	7	4
2001	R:R:L690	R:R:S657	7.51	No	No	0	7	9
2002	R:R:C691	R:R:S657	5.16	Yes	No	0	8	9
2003	R:R:C691	R:R:L658	4.76	Yes	No	51	8	8
2004	R:R:L658	R:R:L848	11.07	No	No	51	8	7
2005	R:R:L658	R:R:L849	4.15	No	Yes	0	8	8
2006	R:R:C660	R:R:S687	3.44	No	No	0	7	6
2007	R:R:C661	R:R:F684	5.59	No	Yes	0	7	8
2008	R:R:C661	R:R:S845	5.16	No	No	0	7	8
2009	R:R:F662	R:R:S845	7.93	Yes	No	0	8	8
2010	R:R:F662	R:R:F846	2.14	Yes	No	0	8	6
2011	R:R:F684	R:R:S664	5.28	Yes	No	0	8	6
2012	R:R:S665	R:R:V838	4.85	No	Yes	21	8	7
2013	R:R:L842	R:R:S665	7.51	Yes	No	21	9	8
2014	R:R:F667	R:R:T676	3.89	No	No	0	5	7
2015	R:R:F667	R:R:L679	2.44	No	No	0	5	5
2016	R:R:F668	R:R:R680	18.17	Yes	No	0	9	8
2017	R:R:E837	R:R:F668	9.33	Yes	Yes	0	9	9
2018	R:R:F668	R:R:V838	2.62	Yes	Yes	0	9	7
2019	R:R:F668	R:R:I841	3.77	Yes	Yes	0	9	9
2020	R:R:I669	R:R:V838	3.07	Yes	Yes	21	8	7
2021	R:R:E671	R:R:Q673	6.37	No	No	0	4	4
2022	R:R:I763	R:R:P672	8.47	Yes	No	0	7	9
2023	R:R:C765	R:R:P672	1.88	No	No	0	9	9
2024	R:R:Q673	R:R:W675	16.43	No	No	24	4	3
2025	R:R:Q673	R:R:T676	2.83	No	No	24	4	7
2026	R:R:D674	R:R:R678	13.1	No	Yes	0	3	5
2027	R:R:D674	R:R:S749	5.89	No	No	0	3	5
2028	R:R:T676	R:R:W675	4.85	No	No	24	7	3
2029	R:R:R678	R:R:W675	3	Yes	No	24	5	3
2030	R:R:C677	R:R:P748	1.88	No	Yes	0	9	9
2031	R:R:C677	R:R:C765	5.46	No	No	0	9	9
2032	R:R:L679	R:R:R678	2.43	No	Yes	0	5	5
2033	R:R:L743	R:R:R678	3.64	No	Yes	0	7	5
2034	R:R:P747	R:R:R678	4.32	No	Yes	24	8	5
2035	R:R:P748	R:R:R678	2.88	Yes	Yes	24	9	5
2036	R:R:C765	R:R:R680	9.75	No	No	0	9	8
2037	R:R:Q681	R:R:W742	6.57	Yes	Yes	0	9	9
2038	R:R:L773	R:R:Q681	13.31	No	Yes	9	8	9
2039	R:R:E837	R:R:Q681	2.55	Yes	Yes	9	9	9
2040	R:R:Q681	W:W:?4	6.95	Yes	Yes	9	9	0
2041	R:R:C739	R:R:P682	7.53	No	No	0	7	5
2042	R:R:P682	R:R:W742	6.76	No	Yes	0	5	9
2043	R:R:F684	R:R:G685	3.01	Yes	No	9	8	8
2044	R:R:F684	R:R:F688	7.5	Yes	Yes	0	8	8
2045	R:R:F684	R:R:W818	3.01	Yes	Yes	9	8	9
2046	R:R:F684	R:R:I841	17.58	Yes	Yes	9	8	9
2047	R:R:F684	W:W:?4	19.07	Yes	Yes	9	8	0
2048	R:R:G685	W:W:?4	2.55	No	Yes	9	8	0
2049	R:R:I686	R:R:Q735	2.74	No	Yes	0	7	9
2050	R:R:I686	R:R:I736	4.42	No	No	0	7	5
2051	R:R:C739	R:R:I686	4.91	No	No	0	7	7
2052	R:R:F688	R:R:I692	8.79	Yes	No	0	8	7
2053	R:R:F688	R:R:T780	2.59	Yes	No	0	8	7
2054	R:R:F688	R:R:F814	13.93	Yes	Yes	0	8	9
2055	R:R:Q735	R:R:V689	14.33	Yes	No	52	9	7
2056	R:R:V689	R:R:Y779	3.79	No	Yes	52	7	9
2057	R:R:F729	R:R:L690	2.44	No	No	0	3	7
2058	R:R:L690	R:R:T732	7.37	No	No	0	7	7
2059	R:R:C691	R:R:L848	3.17	Yes	No	51	8	7
2060	R:R:C787	R:R:I692	3.27	Yes	No	0	8	7
2061	R:R:S693	R:R:V728	8.08	No	Yes	0	9	7
2062	R:R:C731	R:R:S693	5.16	No	No	0	5	9
2063	R:R:S693	R:R:T732	3.2	No	No	0	9	7
2064	R:R:C694	R:R:V728	3.42	No	Yes	4	6	7
2065	R:R:C787	R:R:I695	3.27	Yes	Yes	0	8	7
2066	R:R:I695	R:R:I807	4.42	Yes	No	0	7	9
2067	R:R:I695	R:R:I852	4.42	Yes	No	0	7	9
2068	R:R:I786	R:R:L696	4.28	No	No	53	4	8
2069	R:R:C787	R:R:L696	3.17	Yes	No	0	8	8
2070	R:R:F790	R:R:L696	8.53	Yes	No	53	7	8
2071	R:R:L727	R:R:V697	2.98	No	No	0	7	8
2072	R:R:V697	R:R:V728	4.81	No	Yes	4	8	7
2073	R:R:E803	R:R:K698	2.7	Yes	Yes	4	9	9
2074	R:R:K698	R:R:K856	2.87	Yes	Yes	4	9	9
2075	R:R:F790	R:R:T699	2.59	Yes	No	0	7	9
2076	R:R:F790	R:R:N700	9.67	Yes	No	0	7	7
2077	R:R:L721	R:R:R701	2.43	No	Yes	0	6	8
2078	R:R:Q724	R:R:R701	16.35	Yes	Yes	4	8	8
2079	A:A:Y391	R:R:R701	7.2	Yes	Yes	4	4	8
2080	R:R:F801	R:R:V702	6.55	Yes	No	0	9	9
2081	A:A:L393	R:R:V702	2.98	Yes	No	0	8	9
2082	R:R:K793	R:R:L703	2.82	No	No	0	7	7
2083	R:R:L703	R:R:L797	2.77	No	Yes	0	7	8
2084	R:R:F706	R:R:V705	3.93	Yes	Yes	4	9	9
2085	A:A:L388	R:R:V705	2.98	Yes	Yes	4	8	9
2086	A:A:Y391	R:R:V705	5.05	Yes	Yes	4	4	9
2087	A:A:L393	R:R:V705	2.98	Yes	Yes	4	8	9
2088	R:R:F706	R:R:L797	4.87	Yes	Yes	4	9	8
2089	R:R:F706	R:R:P798	5.78	Yes	No	0	9	9
2090	R:R:F706	R:R:F801	5.36	Yes	Yes	4	9	9
2091	A:A:L384	R:R:F706	6.09	No	Yes	0	6	9
2092	R:R:E707	R:R:K709	6.75	No	No	32	6	8
2093	A:A:N387	R:R:E707	3.94	Yes	No	32	8	6
2094	A:A:I383	R:R:K709	2.91	No	No	32	8	8
2095	A:A:N387	R:R:K709	5.6	Yes	No	32	8	8
2096	R:R:L723	R:R:W719	11.39	No	No	0	7	6
2097	R:R:L726	R:R:L730	2.77	No	No	0	4	3
2098	R:R:F733	R:R:V737	7.87	No	No	0	4	3
2099	R:R:M734	R:R:Y779	11.97	No	Yes	0	4	9
2100	R:R:L776	R:R:Q735	10.65	No	Yes	0	8	9
2101	R:R:Q735	R:R:Y779	7.89	Yes	Yes	52	9	9
2102	R:R:Q735	R:R:T780	5.67	Yes	No	0	9	7
2103	R:R:I741	R:R:V737	3.07	No	No	0	4	3
2104	R:R:I738	R:R:L776	4.28	No	No	0	8	8
2105	R:R:P748	R:R:W742	8.11	Yes	Yes	0	9	9
2106	R:R:S769	R:R:W742	4.94	No	Yes	0	9	9
2107	R:R:A772	R:R:W742	7.78	No	Yes	0	6	9
2108	R:R:A746	R:R:P747	1.87	No	No	0	6	8
2109	R:R:A746	R:R:S769	3.42	No	No	0	6	9
2110	R:R:P747	R:R:P748	1.95	No	Yes	24	8	9
2111	R:R:I763	R:R:S750	3.1	Yes	No	0	7	6
2112	R:R:N753	R:R:Y751	15.12	Yes	Yes	25	7	3
2113	R:R:E755	R:R:Y751	5.61	No	Yes	25	4	3
2114	R:R:T764	R:R:Y751	3.75	No	Yes	0	7	3
2115	R:R:H766	R:R:Y751	2.18	No	Yes	0	6	3
2116	R:R:I761	R:R:R752	3.76	Yes	No	0	7	3
2117	R:R:I763	R:R:R752	5.01	Yes	No	0	7	3
2118	R:R:E755	R:R:N753	7.89	No	Yes	25	4	7
2119	R:R:L756	R:R:N753	4.12	No	Yes	0	5	7
2120	R:R:F762	R:R:N753	2.42	Yes	Yes	0	7	7
2121	R:R:E755	R:R:Q754	14.02	No	No	25	4	4
2122	R:R:I761	R:R:Q754	5.49	Yes	No	25	7	4
2123	R:R:E757	R:R:E759	6.34	No	No	0	4	4
2124	R:R:E757	R:R:I760	8.2	No	No	0	4	5
2125	R:R:E757	R:R:F762	5.83	No	Yes	0	4	7
2126	R:R:D758	R:R:E759	3.9	No	No	16	4	4
2127	R:R:F762	R:R:G830	7.53	Yes	No	0	7	8
2128	R:R:E767	R:R:H766	3.69	No	No	0	7	6
2129	R:R:G768	R:R:H766	3.18	No	No	0	7	6
2130	R:R:E767	R:R:L770	2.65	No	No	0	7	3
2131	R:R:F775	R:R:M771	3.73	No	No	0	4	3
2132	R:R:I777	R:R:L773	4.28	No	No	9	8	8
2133	R:R:L773	W:W:?4	2.06	No	Yes	9	8	0
2134	R:R:L776	W:W:?4	4.13	No	Yes	0	8	0
2135	R:R:G778	R:R:I777	3.53	No	No	0	5	8
2136	R:R:I777	W:W:?4	17.02	No	Yes	9	8	0
2137	R:R:C781	R:R:G778	1.96	No	No	0	7	5
2138	R:R:L783	R:R:Y779	12.89	No	Yes	0	9	9
2139	R:R:T780	W:W:?4	6.59	No	Yes	0	7	0
2140	R:R:C781	R:R:F815	5.59	No	Yes	0	7	7
2141	R:R:A784	R:R:F814	2.77	No	Yes	9	8	9
2142	R:R:A784	R:R:F815	4.16	No	Yes	9	8	7
2143	R:R:F790	R:R:I786	2.51	Yes	No	53	7	4
2144	R:R:C787	R:R:M811	6.48	Yes	No	0	8	9
2145	R:R:F788	R:R:T808	6.49	Yes	No	0	8	9
2146	R:R:F788	R:R:M811	9.95	Yes	No	0	8	9
2147	R:R:F788	R:R:L812	4.87	Yes	No	0	8	9
2148	R:R:F788	R:R:F815	2.14	Yes	Yes	0	8	7
2149	R:R:F789	R:R:F790	2.14	No	Yes	0	4	7
2150	R:R:A791	R:R:I807	4.87	No	No	0	9	9
2151	R:R:F792	R:R:R795	3.21	No	No	0	8	9
2152	R:R:K793	R:R:R795	2.48	No	No	0	7	9
2153	R:R:L797	R:R:S794	7.51	Yes	No	0	8	9
2154	R:R:K796	R:R:R795	18.56	No	No	0	7	9
2155	R:R:F801	R:R:L797	2.44	Yes	Yes	4	9	8
2156	R:R:L797	R:R:N802	2.75	Yes	No	0	8	9
2157	R:R:F801	R:R:N800	2.42	Yes	No	0	9	7
2158	A:A:L388	R:R:F801	6.09	Yes	Yes	4	8	9
2159	R:R:A804	R:R:N802	4.69	No	No	0	9	9
2160	R:R:E803	R:R:F806	2.33	Yes	No	0	9	5
2161	R:R:E803	R:R:I807	2.73	Yes	No	0	9	9
2162	R:R:E803	R:R:K856	10.8	Yes	Yes	4	9	9
2163	R:R:F806	R:R:N855	13.29	No	No	0	5	9
2164	R:R:L848	R:R:S810	6.01	No	No	0	7	9
2165	R:R:C851	R:R:S810	5.16	No	No	0	8	9
2166	R:R:G847	R:R:I813	3.53	No	No	0	8	8
2167	R:R:F814	R:R:F815	10.72	Yes	Yes	9	9	7
2168	R:R:F814	R:R:W818	8.02	Yes	Yes	9	9	9
2169	R:R:A844	R:R:F814	2.77	No	Yes	9	9	9
2170	R:R:F814	W:W:?4	3.63	Yes	Yes	9	9	0
2171	R:R:F821	R:R:V817	2.62	Yes	No	0	9	9
2172	R:R:A843	R:R:V817	5.09	No	No	0	7	9
2173	R:R:A840	R:R:W818	7.78	No	Yes	0	9	9
2174	R:R:I841	R:R:W818	2.35	Yes	Yes	9	9	9
2175	R:R:A844	R:R:W818	2.59	No	Yes	9	9	9
2176	R:R:W818	W:W:?4	33.96	Yes	Yes	9	9	0
2177	R:R:F821	R:R:S820	3.96	Yes	No	23	9	7
2178	R:R:F821	R:R:V836	9.18	Yes	No	23	9	8
2179	R:R:F821	R:R:I839	5.02	Yes	No	0	9	7
2180	R:R:A840	R:R:F821	2.77	No	Yes	0	9	9
2181	R:R:I822	R:R:P823	3.39	Yes	Yes	9	7	9
2182	R:R:I822	W:W:?4	4.26	Yes	Yes	9	7	0
2183	R:R:A824	R:R:V836	3.39	No	No	23	7	8
2184	R:R:E837	R:R:Y825	2.24	Yes	No	9	9	9
2185	R:R:Y825	W:W:?4	11.36	No	Yes	9	9	0
2186	R:R:F832	R:R:T828	3.89	No	Yes	0	5	8
2187	R:R:V833	R:R:Y829	3.79	No	No	0	6	6
2188	R:R:E837	W:W:?4	11.85	Yes	Yes	9	9	0
2189	R:R:L842	R:R:V838	2.98	Yes	Yes	21	9	7
2190	R:R:I841	W:W:?4	2.13	Yes	Yes	9	9	0
2191	R:R:A850	R:R:F846	2.77	No	No	0	1	6
2192	R:R:F853	R:R:L849	2.44	Yes	Yes	0	9	8
2193	R:R:F854	R:R:L849	3.65	No	Yes	0	4	8
2194	R:R:A850	R:R:F854	4.16	No	No	0	1	4
2195	R:R:F853	R:R:I852	10.05	Yes	No	4	9	9
2196	R:R:I852	R:R:K856	2.91	No	Yes	4	9	9
2197	R:R:F853	R:R:K856	4.96	Yes	Yes	4	9	9
2198	R:R:F862	R:R:Y858	18.57	No	No	0	5	8
2199	R:R:K863	R:R:Y858	2.39	No	No	0	7	8
2200	A:A:K17	A:A:V12	3.04	No	No	0	4	1
2201	A:A:E15	A:A:S13	2.87	No	No	0	5	7
2202	A:A:D16	A:A:S13	8.83	No	No	0	4	7
2203	A:A:I26	A:A:R22	3.76	Yes	No	0	9	4
2204	A:A:R22	B:B:H91	4.51	No	Yes	0	4	5
2205	A:A:S23	B:B:N88	8.94	No	Yes	0	7	7
2206	A:A:S23	B:B:K89	7.65	No	Yes	0	7	9
2207	A:A:D27	A:A:I26	2.8	No	Yes	5	6	9
2208	A:A:I26	B:B:K89	5.82	Yes	Yes	5	9	9
2209	A:A:I26	B:B:A92	3.25	Yes	No	0	9	6
2210	A:A:D27	B:B:K89	19.36	No	Yes	5	6	9
2211	A:A:L30	B:B:L55	2.77	No	No	0	5	6
2212	A:A:L30	B:B:I80	2.85	No	Yes	0	5	8
2213	A:A:E35	A:A:R31	2.33	No	No	0	4	4
2214	A:A:E32	A:A:K36	4.05	No	No	0	3	1
2215	A:A:D33	A:A:K36	5.53	No	No	0	5	1
2216	A:A:D33	B:B:K78	5.53	No	No	0	5	8
2217	A:A:A37	A:A:G34	1.95	No	No	0	3	5
2218	A:A:G34	B:B:L55	3.42	No	No	0	5	6
2219	A:A:E35	A:A:R38	4.65	No	No	0	4	4
2220	A:A:K36	A:A:R39	9.9	No	No	0	1	5
2221	A:A:N218	A:A:T40	7.31	Yes	No	0	4	7
2222	A:A:F219	A:A:L41	7.31	Yes	No	0	8	6
2223	A:A:L41	A:A:T242	5.9	No	No	0	6	8
2224	A:A:I383	A:A:L41	2.85	No	No	0	8	6
2225	A:A:F222	A:A:R42	5.34	Yes	Yes	3	7	9
2226	A:A:D240	A:A:R42	9.53	No	Yes	0	6	9
2227	A:A:R42	A:A:V241	3.92	Yes	No	0	9	9
2228	A:A:R42	B:B:W99	3	Yes	Yes	3	9	9
2229	A:A:F219	A:A:L43	2.44	Yes	No	0	8	7
2230	A:A:L43	A:A:T242	2.95	No	No	0	7	8
2231	A:A:I245	A:A:L43	7.14	No	No	0	7	7
2232	A:A:L44	A:A:L46	2.77	No	Yes	3	9	8
2233	A:A:F238	A:A:L44	9.74	Yes	No	3	9	9
2234	A:A:I244	A:A:L44	4.28	Yes	No	3	8	9
2235	A:A:K53	A:A:L45	4.23	No	Yes	3	9	8
2236	A:A:L45	A:A:M221	8.48	Yes	Yes	0	8	8
2237	A:A:D223	A:A:L45	4.07	No	Yes	3	9	8
2238	A:A:I245	A:A:L45	2.85	No	Yes	0	7	8
2239	A:A:G47	A:A:L46	3.42	Yes	Yes	3	9	8
2240	A:A:L46	A:A:R231	4.86	Yes	Yes	0	8	9
2241	A:A:I244	A:A:L46	2.85	Yes	Yes	3	8	8
2242	A:A:F246	A:A:L46	4.87	Yes	Yes	3	9	8
2243	A:A:I276	A:A:L46	4.28	Yes	Yes	3	8	8
2244	A:A:G47	A:A:S51	1.86	Yes	Yes	0	9	9
2245	A:A:G47	A:A:K53	3.49	Yes	No	3	9	9
2246	A:A:F246	A:A:G47	3.01	Yes	Yes	3	9	9
2247	A:A:A48	A:A:N50	3.13	No	Yes	0	8	9
2248	A:A:A48	A:A:S51	3.42	No	Yes	0	8	9
2249	A:A:D49	A:A:N50	6.73	No	Yes	0	8	9
2250	A:A:D249	A:A:N50	13.46	Yes	Yes	0	8	9
2251	A:A:N50	A:A:R265	7.23	Yes	No	0	9	9
2252	A:A:S51	A:A:V247	4.85	Yes	Yes	0	9	7
2253	A:A:D249	A:A:S51	2.94	Yes	Yes	0	8	9
2254	A:A:G52	A:A:T55	1.82	No	No	0	9	9
2255	A:A:D223	A:A:K53	2.77	No	No	3	9	9
2256	A:A:I56	A:A:V247	10.75	Yes	Yes	13	7	7
2257	A:A:F290	A:A:I56	3.77	Yes	Yes	13	9	7
2258	A:A:I56	A:A:N292	8.5	Yes	Yes	13	7	9
2259	A:A:I56	A:A:T364	4.56	Yes	Yes	13	7	9
2260	A:A:M221	A:A:V57	3.04	Yes	No	0	8	7
2261	A:A:K58	A:A:Q59	8.14	No	No	0	9	9
2262	A:A:K58	A:A:T369	6.01	No	No	0	9	9
2263	A:A:Q59	A:A:R61	11.68	No	No	0	9	8
2264	A:A:M60	A:A:T210	3.01	No	No	0	9	7
2265	A:A:F212	A:A:R61	3.21	Yes	No	0	9	8
2266	A:A:Q213	A:A:R61	4.67	No	No	0	3	8
2267	A:A:F222	A:A:I207	2.51	Yes	No	0	7	9
2268	A:A:I207	A:A:V224	4.61	No	Yes	0	9	9
2269	A:A:I207	B:B:L117	4.28	No	Yes	0	9	9
2270	A:A:E209	A:A:H220	8.62	No	Yes	3	9	7
2271	A:A:E209	A:A:F222	7	No	Yes	3	9	7
2272	A:A:M221	A:A:T210	4.52	Yes	No	0	8	7
2273	A:A:K211	A:A:N218	19.58	No	Yes	3	4	4
2274	A:A:H220	A:A:K211	14.41	Yes	No	3	7	4
2275	A:A:F212	A:A:F219	9.65	Yes	Yes	0	9	8
2276	A:A:F212	A:A:M221	4.98	Yes	Yes	0	9	8
2277	A:A:A372	A:A:F212	2.77	No	Yes	0	8	9
2278	A:A:N218	A:A:Q213	9.24	Yes	No	0	4	3
2279	A:A:D215	A:A:V214	2.92	No	No	18	5	6
2280	A:A:F376	A:A:V214	2.62	Yes	No	18	8	6
2281	A:A:D215	A:A:R373	3.57	No	No	18	5	5
2282	A:A:D215	A:A:F376	13.14	No	Yes	18	5	8
2283	A:A:F219	A:A:V217	3.93	Yes	No	18	8	5
2284	A:A:F376	A:A:V217	2.62	Yes	No	18	8	5
2285	A:A:H220	A:A:N218	3.83	Yes	Yes	3	7	4
2286	A:A:F219	A:A:F376	4.29	Yes	Yes	18	8	8
2287	A:A:C379	A:A:F219	4.19	No	Yes	18	8	8
2288	A:A:F222	A:A:H220	2.26	Yes	Yes	3	7	7
2289	A:A:F222	B:B:W99	16.04	Yes	Yes	3	7	9
2290	A:A:G225	A:A:V224	1.84	No	Yes	0	9	9
2291	A:A:Q227	A:A:V224	8.6	No	Yes	3	9	9
2292	A:A:V224	A:A:W234	15.94	Yes	Yes	3	9	9
2293	A:A:F238	A:A:V224	2.62	Yes	Yes	3	9	9
2294	A:A:G225	A:A:G226	2.11	No	No	0	9	9
2295	A:A:Q227	A:A:W234	6.57	No	Yes	3	9	9
2296	A:A:R228	B:B:T143	9.06	No	No	3	9	5
2297	A:A:R228	B:B:D163	7.15	No	Yes	3	9	9
2298	A:A:E230	A:A:R232	20.93	No	Yes	3	9	8
2299	A:A:E230	B:B:D186	11.69	No	Yes	3	9	9
2300	A:A:E230	B:B:C204	4.56	No	Yes	3	9	7
2301	A:A:R231	A:A:W234	9	Yes	Yes	0	9	9
2302	A:A:D272	A:A:R231	4.76	No	Yes	0	8	9
2303	A:A:K233	A:A:R232	2.48	Yes	Yes	3	9	8
2304	A:A:R232	B:B:C204	2.79	Yes	Yes	3	8	7
2305	A:A:R232	B:B:D228	10.72	Yes	Yes	3	8	9
2306	A:A:K233	B:B:Y145	3.58	Yes	Yes	3	9	8
2307	A:A:K233	B:B:M188	10.08	Yes	No	0	9	8
2308	A:A:K233	B:B:D228	4.15	Yes	Yes	3	9	9
2309	A:A:K233	B:B:N230	4.2	Yes	No	0	9	9
2310	A:A:I235	A:A:W234	3.52	No	Yes	3	9	9
2311	A:A:F238	A:A:W234	4.01	Yes	Yes	3	9	9
2312	A:A:W234	B:B:L117	2.28	Yes	Yes	3	9	9
2313	A:A:W234	B:B:Y145	3.86	Yes	Yes	3	9	8
2314	A:A:I235	A:A:N279	4.25	No	No	3	9	8
2315	A:A:I235	A:A:L282	2.85	No	Yes	3	9	9
2316	A:A:Q236	A:A:W281	18.62	No	Yes	3	8	5
2317	A:A:Q236	B:B:R314	9.35	No	Yes	3	8	8
2318	A:A:Q236	B:B:W332	7.67	No	Yes	3	8	9
2319	A:A:C237	A:A:F238	2.79	No	Yes	0	8	9
2320	A:A:C237	B:B:Y59	6.72	No	Yes	0	8	8
2321	A:A:C237	B:B:M101	4.86	No	No	0	8	9
2322	A:A:F238	A:A:V241	2.62	Yes	No	0	9	9
2323	A:A:F238	B:B:W99	15.03	Yes	Yes	3	9	9
2324	A:A:F238	B:B:L117	2.44	Yes	Yes	3	9	9
2325	A:A:N239	B:B:K57	5.6	No	Yes	3	8	9
2326	A:A:N239	B:B:W332	10.17	No	Yes	3	8	9
2327	A:A:I285	A:A:V241	3.07	No	No	0	7	9
2328	A:A:I244	A:A:I276	2.94	Yes	Yes	3	8	8
2329	A:A:I244	A:A:V287	6.14	Yes	No	3	8	6
2330	A:A:I245	A:A:I288	4.42	No	Yes	0	7	9
2331	A:A:F246	A:A:V248	6.55	Yes	No	0	9	7
2332	A:A:D272	A:A:F246	8.36	No	Yes	0	8	9
2333	A:A:F246	A:A:F273	6.43	Yes	Yes	3	9	9
2334	A:A:F246	A:A:L289	2.44	Yes	No	0	9	9
2335	A:A:F290	A:A:V247	3.93	Yes	Yes	13	9	7
2336	A:A:N292	A:A:V247	4.43	Yes	Yes	13	9	7
2337	A:A:A269	A:A:V248	3.39	No	No	0	9	7
2338	A:A:F345	A:A:V248	2.62	Yes	No	0	8	7
2339	A:A:D249	A:A:S251	4.42	Yes	No	0	8	9
2340	A:A:D249	A:A:K293	9.68	Yes	No	0	8	9
2341	A:A:L297	A:A:S250	7.51	No	No	0	8	6
2342	A:A:I341	A:A:S250	3.1	No	No	0	8	6
2343	A:A:D252	A:A:S251	5.89	No	No	0	8	9
2344	A:A:L296	A:A:S251	4.5	No	No	0	6	9
2345	A:A:D252	A:A:N264	2.69	No	No	0	8	4
2346	A:A:D252	A:A:K300	2.77	No	Yes	0	8	9
2347	A:A:K300	A:A:Y253	13.14	Yes	No	0	9	4
2348	A:A:I308	A:A:Y253	22.97	No	No	0	7	4
2349	A:A:Y253	A:A:Y311	5.96	No	No	0	4	6
2350	A:A:N264	A:A:Y311	11.63	No	No	0	4	6
2351	A:A:E268	A:A:Q267	3.82	No	No	0	9	4
2352	A:A:F312	A:A:Q267	17.57	No	No	0	8	4
2353	A:A:L270	A:A:N271	4.12	Yes	No	0	6	5
2354	A:A:K274	A:A:L270	2.82	No	Yes	3	5	6
2355	A:A:F345	A:A:L270	3.65	Yes	Yes	3	8	6
2356	A:A:I348	A:A:L270	4.28	Yes	Yes	3	4	6
2357	A:A:D272	A:A:I276	2.8	No	Yes	0	8	8
2358	A:A:F273	A:A:W277	5.01	Yes	Yes	3	9	6
2359	A:A:F273	A:A:V287	5.24	Yes	No	3	9	6
2360	A:A:F273	A:A:F345	5.36	Yes	Yes	3	9	8
2361	A:A:F273	A:A:I348	5.02	Yes	Yes	3	9	4
2362	A:A:F273	A:A:S349	2.64	Yes	Yes	3	9	7
2363	A:A:I348	A:A:K274	13.09	Yes	No	3	4	5
2364	A:A:I276	A:A:L282	2.85	Yes	Yes	3	8	9
2365	A:A:N278	A:A:W277	5.65	No	Yes	0	8	6
2366	A:A:V287	A:A:W277	4.9	No	Yes	3	6	6
2367	A:A:S349	A:A:W277	7.41	Yes	Yes	3	7	6
2368	A:A:H357	A:A:W277	29.62	No	Yes	0	7	6
2369	A:A:C359	A:A:W277	2.61	No	Yes	3	5	6
2370	A:A:N278	A:A:S352	5.96	No	No	0	8	5
2371	A:A:N279	A:A:W281	3.39	No	Yes	3	8	5
2372	A:A:L282	A:A:N279	5.49	Yes	No	3	9	8
2373	A:A:R280	A:A:W281	13.99	No	Yes	0	5	5
2374	A:A:R280	A:A:R283	4.26	No	No	0	5	3
2375	A:A:W281	B:B:D290	7.82	Yes	No	3	5	6
2376	A:A:W281	B:B:R314	9	Yes	Yes	3	5	8
2377	A:A:W281	B:B:W332	3.75	Yes	Yes	3	5	9
2378	A:A:I285	A:A:L282	5.71	No	Yes	0	7	9
2379	A:A:R283	A:A:T284	6.47	No	No	0	3	4
2380	A:A:R356	A:A:T284	2.59	No	No	0	2	4
2381	A:A:S286	A:A:Y360	2.54	No	Yes	13	8	8
2382	A:A:I382	A:A:S286	9.29	No	No	13	6	8
2383	A:A:F290	A:A:I288	6.28	Yes	Yes	13	9	9
2384	A:A:I288	A:A:Y360	2.42	Yes	Yes	13	9	8
2385	A:A:H362	A:A:I288	6.63	Yes	Yes	13	9	9
2386	A:A:I288	A:A:I375	2.94	Yes	No	13	9	9
2387	A:A:D378	A:A:I288	12.59	No	Yes	13	7	9
2388	A:A:F345	A:A:L289	6.09	Yes	No	0	8	9
2389	A:A:F290	A:A:H362	9.05	Yes	Yes	13	9	9
2390	A:A:F290	A:A:T364	14.27	Yes	Yes	13	9	9
2391	A:A:F290	A:A:R374	2.14	Yes	Yes	13	9	4
2392	A:A:F290	A:A:I375	6.28	Yes	No	13	9	9
2393	A:A:I341	A:A:L291	2.85	No	Yes	3	8	8
2394	A:A:L291	A:A:R342	2.43	Yes	Yes	3	8	4
2395	A:A:F345	A:A:L291	2.44	Yes	Yes	3	8	8
2396	A:A:F363	A:A:L291	9.74	Yes	Yes	3	5	8
2397	A:A:K293	A:A:N292	9.79	No	Yes	0	9	9
2398	A:A:N292	A:A:T364	2.92	Yes	Yes	13	9	9
2399	A:A:L297	A:A:Q294	2.66	No	No	0	8	6
2400	A:A:K338	A:A:Q294	2.71	Yes	No	0	5	6
2401	A:A:C365	A:A:Q294	6.1	Yes	No	0	8	6
2402	A:A:C365	A:A:D295	3.11	Yes	No	0	8	9
2403	A:A:L296	A:A:L297	2.77	No	No	0	6	8
2404	A:A:A298	A:A:L302	3.15	No	Yes	33	4	2
2405	A:A:A298	A:A:V334	5.09	No	Yes	33	4	4
2406	A:A:E299	A:A:L302	2.65	No	Yes	0	6	2
2407	A:A:K300	A:A:K305	8.62	Yes	No	54	9	3
2408	A:A:K300	A:A:S306	3.06	Yes	No	54	9	7
2409	A:A:V301	A:A:V334	4.81	No	Yes	0	7	4
2410	A:A:A337	A:A:V301	5.09	No	No	0	8	7
2411	A:A:D331	A:A:L302	4.07	Yes	Yes	33	4	2
2412	A:A:L302	A:A:V334	2.98	Yes	Yes	33	2	4
2413	A:A:A303	A:A:G304	1.95	No	No	0	5	5
2414	A:A:G304	A:A:K307	5.23	No	No	0	5	6
2415	A:A:K305	A:A:S306	7.65	No	No	54	3	7
2416	A:A:E309	A:A:K307	2.7	No	No	0	4	6
2417	A:A:F312	A:A:I308	2.51	No	No	0	8	7
2418	A:A:F315	A:A:I308	27.63	No	No	0	6	7
2419	A:A:D310	A:A:E309	5.2	No	No	0	3	4
2420	A:A:D310	A:A:Y311	4.6	No	No	0	3	6
2421	A:A:F312	A:A:P313	4.33	No	No	0	8	6
2422	A:A:A337	A:A:F315	2.77	No	No	0	8	6
2423	A:A:F315	A:A:F340	25.72	No	Yes	0	6	7
2424	A:A:R317	A:A:T319	5.17	No	No	0	2	5
2425	A:A:R336	A:A:Y318	2.06	No	Yes	0	5	6
2426	A:A:Y318	A:A:Y339	20.85	Yes	Yes	3	6	3
2427	A:A:F340	A:A:Y318	3.09	Yes	Yes	3	7	6
2428	A:A:K343	A:A:Y318	28.66	No	Yes	3	3	6
2429	A:A:D331	A:A:P332	6.44	Yes	No	0	4	1
2430	A:A:D331	A:A:R333	4.76	Yes	No	0	4	5
2431	A:A:D331	A:A:V334	5.84	Yes	Yes	33	4	4
2432	A:A:P332	A:A:R336	5.76	No	No	0	1	5
2433	A:A:K338	A:A:T335	3	Yes	No	3	5	4
2434	A:A:T335	A:A:Y339	2.5	No	Yes	3	4	3
2435	A:A:K338	A:A:Y339	4.78	Yes	Yes	3	5	3
2436	A:A:F363	A:A:K338	22.33	Yes	Yes	3	5	5
2437	A:A:R342	A:A:Y339	6.17	Yes	Yes	3	4	3
2438	A:A:F363	A:A:Y339	2.06	Yes	Yes	3	5	3
2439	A:A:F340	A:A:K343	2.48	Yes	No	3	7	3
2440	A:A:E344	A:A:F340	12.83	No	Yes	0	5	7
2441	A:A:F363	A:A:I341	2.51	Yes	No	3	5	8
2442	A:A:P361	A:A:R342	4.32	No	Yes	0	5	4
2443	A:A:F363	A:A:R342	7.48	Yes	Yes	3	5	4
2444	A:A:F345	A:A:I348	2.51	Yes	Yes	3	8	4
2445	A:A:P361	A:A:V346	3.53	No	No	0	5	4
2446	A:A:S349	A:A:T350	3.2	Yes	No	0	7	4
2447	A:A:C359	A:A:S349	6.89	No	Yes	3	5	7
2448	A:A:G353	A:A:H357	3.18	No	No	0	4	7
2449	A:A:D354	A:A:R356	4.76	No	No	0	3	2
2450	A:A:R356	A:A:R389	2.13	No	Yes	0	2	5
2451	A:A:I358	A:A:Y360	3.63	No	Yes	0	4	8
2452	A:A:C359	A:A:P361	3.77	No	No	0	5	5
2453	A:A:H362	A:A:Y360	2.18	Yes	Yes	13	9	8
2454	A:A:D378	A:A:Y360	29.88	No	Yes	13	7	8
2455	A:A:D381	A:A:Y360	10.34	No	Yes	0	8	8
2456	A:A:I382	A:A:Y360	8.46	No	Yes	13	6	8
2457	A:A:H362	A:A:R374	11.28	Yes	Yes	13	9	4
2458	A:A:N371	A:A:T364	4.39	No	Yes	0	9	9
2459	A:A:C365	A:A:V367	3.42	Yes	No	0	8	9
2460	A:A:D368	A:A:E370	16.89	No	No	13	9	4
2461	A:A:D368	A:A:N371	13.46	No	No	0	9	9
2462	A:A:D368	A:A:R374	4.76	No	Yes	13	9	4
2463	A:A:E370	A:A:T369	2.82	No	No	0	4	9
2464	A:A:E370	A:A:R374	12.79	No	Yes	13	4	4
2465	A:A:F376	A:A:R373	2.14	Yes	No	18	8	5
2466	A:A:N377	A:A:R373	8.44	No	No	18	4	5
2467	A:A:F376	A:A:N377	4.83	Yes	No	18	8	4
2468	A:A:C379	A:A:F376	2.79	No	Yes	18	8	8
2469	A:A:K380	A:A:N377	5.6	No	No	0	7	4
2470	A:A:D378	A:A:I382	8.4	No	No	13	7	6
2471	A:A:I383	A:A:N387	4.25	No	Yes	32	8	8
2472	A:A:L384	A:A:L388	4.15	No	Yes	0	6	8
2473	A:A:L388	A:A:Q385	7.99	Yes	No	4	8	5
2474	A:A:Q385	A:A:R389	2.34	No	Yes	4	5	5
2475	A:A:Q385	A:A:V394	8.6	No	Yes	4	5	8
2476	A:A:M386	A:A:R389	11.17	No	Yes	0	4	5
2477	A:A:E390	A:A:N387	9.2	No	Yes	0	4	8
2478	A:A:L388	A:A:V394	8.94	Yes	Yes	4	8	8
2479	A:A:R389	A:A:V394	2.62	Yes	Yes	4	5	8
2480	A:A:E390	A:A:Y391	6.73	No	Yes	0	4	4
2481	A:A:L393	A:A:Y391	2.34	Yes	Yes	4	8	4
2482	B:B:E3	B:B:S2	4.31	No	No	0	5	5
2483	B:B:E3	B:B:L7	13.25	No	Yes	0	5	8
2484	B:B:L4	B:B:R8	2.43	No	No	0	4	3
2485	B:B:L4	G:G:Q11	2.66	No	Yes	0	4	3
2486	B:B:D5	B:B:Q6	9.14	No	No	0	1	1
2487	B:B:E10	B:B:Q6	2.55	Yes	No	0	8	1
2488	B:B:E10	B:B:L7	7.95	Yes	Yes	34	8	8
2489	B:B:L7	G:G:Q11	13.31	Yes	Yes	34	8	3
2490	B:B:L7	G:G:L15	2.77	Yes	Yes	34	8	2
2491	B:B:Q9	B:B:R8	2.34	No	No	0	3	3
2492	B:B:E10	G:G:L15	3.98	Yes	Yes	34	8	2
2493	B:B:A11	G:G:L15	4.73	No	Yes	0	5	2
2494	B:B:E12	B:B:N16	9.2	No	No	0	4	1
2495	B:B:Q13	B:B:Q17	2.56	No	No	0	1	4
2496	B:B:L14	G:G:L19	4.15	No	No	0	8	9
2497	B:B:L14	G:G:K20	9.87	No	No	0	8	6
2498	B:B:K15	G:G:L19	8.46	No	No	0	6	9
2499	B:B:N16	B:B:Q17	6.6	No	No	0	1	4
2500	B:B:I18	B:B:R19	2.51	No	No	0	7	4
2501	B:B:I18	G:G:E22	6.83	No	Yes	0	7	9
2502	B:B:R19	B:B:T223	5.17	No	No	0	4	2
2503	B:B:F222	B:B:R22	2.14	Yes	Yes	3	8	6
2504	B:B:D258	B:B:R22	14.29	Yes	Yes	3	7	6
2505	B:B:Q259	B:B:R22	3.5	No	Yes	0	6	6
2506	B:B:R22	G:G:E22	3.49	Yes	Yes	3	6	9
2507	B:B:A26	B:B:K23	3.21	No	No	0	3	2
2508	B:B:C25	G:G:R27	2.79	No	No	0	3	8
2509	B:B:A26	B:B:Q259	4.55	No	No	0	3	6
2510	B:B:D27	G:G:K29	2.77	No	No	0	8	4
2511	B:B:Q32	B:B:T29	9.92	No	No	0	1	3
2512	B:B:L30	B:B:T34	4.42	Yes	No	0	5	5
2513	B:B:L252	B:B:L30	2.77	No	Yes	3	7	5
2514	B:B:L261	B:B:L30	5.54	Yes	Yes	3	5	5
2515	B:B:L30	B:B:M262	7.07	Yes	Yes	3	5	4
2516	B:B:L300	B:B:T34	11.79	Yes	No	0	6	5
2517	B:B:I37	B:B:N36	5.66	No	No	0	2	1
2518	B:B:I37	B:B:R283	3.76	No	Yes	0	2	9
2519	B:B:I37	G:G:M38	5.83	No	No	0	2	4
2520	B:B:D38	B:B:P39	4.83	No	No	0	1	1
2521	B:B:I43	B:B:V40	3.07	Yes	Yes	0	3	3
2522	B:B:R283	B:B:V40	7.85	Yes	Yes	26	9	3
2523	B:B:D298	B:B:V40	2.92	Yes	Yes	26	9	3
2524	B:B:V40	G:G:L51	2.98	Yes	Yes	26	3	6
2525	B:B:Q44	B:B:R42	4.67	No	No	0	4	2
2526	B:B:I43	B:B:M45	4.37	Yes	Yes	0	3	4
2527	B:B:I43	B:B:L284	4.28	Yes	Yes	0	3	5
2528	B:B:A305	B:B:I43	3.25	No	Yes	0	4	3
2529	B:B:Q44	B:B:R46	3.5	No	No	0	4	5
2530	B:B:M45	B:B:V296	4.56	Yes	Yes	0	4	5
2531	B:B:L308	B:B:M45	5.65	No	Yes	0	7	4
2532	B:B:M45	B:B:N340	7.01	Yes	No	0	4	9
2533	B:B:R46	B:B:R48	2.13	No	No	0	5	7
2534	B:B:K337	B:B:T47	4.5	Yes	No	14	6	3
2535	B:B:T47	B:B:W339	4.85	No	Yes	14	3	9
2536	B:B:N340	B:B:R48	6.03	No	No	0	9	7
2537	B:B:R48	G:G:F61	4.28	No	Yes	0	7	8
2538	B:B:R49	B:B:T87	2.59	No	No	0	7	5
2539	B:B:I338	B:B:R49	2.51	Yes	No	5	5	7
2540	B:B:R49	G:G:F61	11.76	No	Yes	5	7	8
2541	B:B:R52	B:B:T50	7.76	No	No	14	7	3
2542	B:B:F335	B:B:T50	2.59	No	No	14	4	3
2543	B:B:K337	B:B:T50	10.51	Yes	No	14	6	3
2544	B:B:L51	B:B:W82	13.67	No	Yes	0	9	9
2545	B:B:L51	B:B:T87	2.95	No	No	0	9	5
2546	B:B:L336	B:B:L51	5.54	Yes	No	0	7	9
2547	B:B:F335	B:B:R52	10.69	No	No	14	4	7
2548	B:B:G53	B:B:K89	3.49	No	Yes	0	9	9
2549	B:B:H54	B:B:I58	6.63	Yes	Yes	5	9	9
2550	B:B:H54	B:B:S72	6.97	Yes	Yes	5	9	9
2551	B:B:H54	B:B:S74	11.16	Yes	No	5	9	9
2552	B:B:D76	B:B:H54	8.82	Yes	Yes	5	9	9
2553	B:B:H54	B:B:I80	11.93	Yes	Yes	5	9	8
2554	B:B:D76	B:B:L55	2.71	Yes	No	0	9	6
2555	B:B:A56	B:B:D76	3.09	No	Yes	0	7	9
2556	B:B:K57	B:B:Y59	9.55	Yes	Yes	3	9	8
2557	B:B:K57	B:B:Q75	12.2	Yes	Yes	3	9	9
2558	B:B:K57	B:B:W332	15.08	Yes	Yes	3	9	9
2559	B:B:I58	B:B:S74	3.1	Yes	No	5	9	9
2560	B:B:C317	B:B:I58	3.27	No	Yes	0	7	9
2561	B:B:I58	B:B:L336	5.71	Yes	Yes	0	9	7
2562	B:B:Q75	B:B:Y59	4.51	Yes	Yes	3	9	8
2563	B:B:W332	B:B:Y59	12.54	Yes	Yes	3	9	8
2564	B:B:A60	B:B:C103	3.61	No	No	0	7	8
2565	B:B:C317	B:B:M61	9.73	No	No	0	7	6
2566	B:B:G319	B:B:M61	3.49	No	No	0	5	6
2567	B:B:H62	B:B:Y105	4.36	No	Yes	0	6	6
2568	B:B:H62	B:B:R150	12.41	No	Yes	0	6	6
2569	B:B:L70	B:B:W63	5.69	No	Yes	5	5	7
2570	B:B:S84	B:B:W63	7.41	No	Yes	5	5	7
2571	B:B:T321	B:B:W63	16.98	Yes	Yes	5	7	7
2572	B:B:A328	B:B:W63	5.19	No	Yes	0	5	7
2573	B:B:I338	B:B:W63	2.35	Yes	Yes	5	5	7
2574	B:B:G64	B:B:Y105	7.24	No	Yes	0	5	6
2575	B:B:D66	B:B:R68	2.38	No	No	0	8	5
2576	B:B:D66	B:B:L69	10.86	No	Yes	0	8	5
2577	B:B:S67	B:B:T321	7.99	No	Yes	5	5	7
2578	B:B:D323	B:B:S67	8.83	No	No	5	7	5
2579	B:B:D83	B:B:R68	16.68	No	No	0	8	5
2580	B:B:R68	B:B:Y85	24.69	No	No	0	5	4
2581	B:B:I81	B:B:L69	2.85	Yes	Yes	15	7	5
2582	B:B:L69	B:B:V90	4.47	Yes	No	15	5	5
2583	B:B:L69	B:B:Y105	8.21	Yes	Yes	15	5	6
2584	B:B:L70	B:B:W82	9.11	No	Yes	5	5	9
2585	B:B:L70	B:B:S84	4.5	No	No	5	5	5
2586	B:B:L79	B:B:V71	4.47	No	Yes	0	7	8
2587	B:B:C103	B:B:V71	3.42	No	Yes	0	8	8
2588	B:B:V71	B:B:Y105	7.57	Yes	Yes	0	8	6
2589	B:B:V112	B:B:V71	4.81	No	Yes	0	8	8
2590	B:B:I80	B:B:S72	4.64	Yes	Yes	5	8	9
2591	B:B:S72	B:B:W82	7.41	Yes	Yes	5	9	9
2592	B:B:L336	B:B:S72	3	Yes	Yes	0	7	9
2593	B:B:A73	B:B:V100	3.39	No	No	0	9	9
2594	B:B:A73	B:B:C103	3.61	No	No	0	9	8
2595	B:B:D76	B:B:S74	10.31	Yes	No	5	9	9
2596	B:B:Q75	B:B:W99	13.14	Yes	Yes	3	9	9
2597	B:B:D76	B:B:K78	8.3	Yes	No	0	9	8
2598	B:B:G77	B:B:L95	5.13	No	Yes	0	8	8
2599	B:B:K78	B:B:P94	3.35	No	No	0	8	5
2600	B:B:L79	B:B:L95	4.15	No	Yes	15	7	8
2601	B:B:C114	B:B:L79	4.76	Yes	No	15	8	7
2602	B:B:I80	B:B:W82	15.27	Yes	Yes	5	8	9
2603	B:B:I80	B:B:K89	4.36	Yes	Yes	5	8	9
2604	B:B:I81	B:B:V90	6.14	Yes	No	15	7	5
2605	B:B:H91	B:B:I81	5.3	Yes	Yes	15	5	7
2606	B:B:I81	B:B:Y105	3.63	Yes	Yes	15	7	6
2607	B:B:K89	B:B:W82	10.44	Yes	Yes	5	9	9
2608	B:B:D83	B:B:T86	8.67	No	No	0	8	6
2609	B:B:I338	B:B:S84	3.1	Yes	No	5	5	5
2610	B:B:Y85	G:G:P60	9.74	No	Yes	5	4	9
2611	B:B:Y85	G:G:F61	8.25	No	Yes	5	4	8
2612	B:B:N88	B:B:T86	10.24	Yes	No	0	7	6
2613	B:B:H91	B:B:V90	5.54	Yes	No	15	5	5
2614	B:B:H91	B:B:V133	5.54	Yes	Yes	15	5	4
2615	B:B:I93	B:B:P94	3.39	No	No	0	7	5
2616	B:B:I93	B:B:Y124	6.04	No	Yes	15	7	6
2617	B:B:I93	B:B:V133	12.29	No	Yes	15	7	4
2618	B:B:L95	B:B:V100	4.47	Yes	No	0	8	9
2619	B:B:C114	B:B:L95	4.76	Yes	Yes	15	8	8
2620	B:B:L95	B:B:Y124	5.86	Yes	Yes	15	8	6
2621	B:B:D118	B:B:S97	11.78	No	No	0	9	8
2622	B:B:L117	B:B:W99	4.56	Yes	Yes	3	9	9
2623	B:B:G115	B:B:V100	1.84	Yes	No	0	9	9
2624	B:B:G116	B:B:M101	3.49	No	No	0	9	9
2625	B:B:M101	B:B:Y145	3.59	No	Yes	0	9	8
2626	B:B:G115	B:B:T102	1.82	Yes	No	0	9	8
2627	B:B:C149	B:B:T102	8.45	No	No	0	8	8
2628	B:B:A104	B:B:R150	2.77	No	Yes	0	7	6
2629	B:B:G109	B:B:Y105	2.9	No	Yes	0	5	6
2630	B:B:L126	B:B:Y105	3.52	No	Yes	0	5	6
2631	B:B:A106	B:B:P107	1.87	No	No	3	6	6
2632	B:B:A106	B:B:F151	8.32	No	Yes	3	6	9
2633	B:B:F151	B:B:P107	2.89	Yes	No	3	9	6
2634	B:B:G109	B:B:S108	1.86	No	No	0	5	6
2635	B:B:D154	B:B:S108	8.83	No	No	0	6	6
2636	B:B:N110	B:B:Y111	11.63	Yes	Yes	3	4	4
2637	B:B:N110	B:B:N125	4.09	Yes	Yes	3	4	4
2638	B:B:K127	B:B:N110	8.39	No	Yes	0	4	4
2639	B:B:D154	B:B:N110	4.04	No	Yes	3	6	4
2640	B:B:I123	B:B:Y111	3.63	Yes	Yes	3	6	4
2641	B:B:N125	B:B:Y111	15.12	Yes	Yes	3	4	4
2642	B:B:S136	B:B:Y111	6.36	No	Yes	3	4	4
2643	B:B:F151	B:B:Y111	3.09	Yes	Yes	3	9	4
2644	B:B:D154	B:B:Y111	9.2	No	Yes	3	6	4
2645	B:B:L126	B:B:V112	4.47	No	No	0	5	8
2646	B:B:A113	B:B:F151	4.16	No	Yes	0	9	9
2647	B:B:C114	B:B:G115	1.96	Yes	Yes	0	8	9
2648	B:B:C114	B:B:Y124	5.38	Yes	Yes	15	8	6
2649	B:B:G115	B:B:G116	2.11	Yes	No	0	9	9
2650	B:B:G115	B:B:L146	3.42	Yes	No	0	9	7
2651	B:B:L117	B:B:Y145	2.34	Yes	Yes	3	9	8
2652	B:B:G144	B:B:N119	3.39	Yes	No	0	8	9
2653	B:B:E138	B:B:I120	4.1	No	No	0	6	6
2654	B:B:A140	B:B:I120	4.87	No	No	0	5	6
2655	B:B:C121	B:B:L139	4.76	No	Yes	0	8	9
2656	B:B:C121	B:B:C149	5.46	No	No	3	8	8
2657	B:B:C121	B:B:T159	3.38	No	Yes	3	8	9
2658	B:B:S122	B:B:Y124	10.17	No	Yes	15	8	6
2659	B:B:S122	B:B:V135	3.23	No	No	15	8	4
2660	B:B:E138	B:B:S122	5.75	No	No	0	6	8
2661	B:B:I123	B:B:L139	4.28	Yes	Yes	0	6	9
2662	B:B:F151	B:B:I123	5.02	Yes	Yes	3	9	6
2663	B:B:I123	B:B:I157	5.89	Yes	Yes	3	6	7
2664	B:B:I123	B:B:I171	4.42	Yes	Yes	3	6	6
2665	B:B:V133	B:B:Y124	3.79	Yes	Yes	15	4	6
2666	B:B:V135	B:B:Y124	5.05	No	Yes	15	4	6
2667	B:B:N125	B:B:R134	4.82	Yes	Yes	3	4	3
2668	B:B:N125	B:B:S136	5.96	Yes	No	3	4	4
2669	B:B:L126	B:B:V133	2.98	No	Yes	0	5	4
2670	B:B:E130	B:B:T128	2.82	No	No	0	3	3
2671	B:B:G131	B:B:T128	1.82	No	No	0	4	3
2672	B:B:R134	B:B:T128	2.59	Yes	No	0	3	3
2673	B:B:E130	B:B:N132	9.2	No	No	0	3	3
2674	B:B:N132	B:B:R134	2.41	No	Yes	0	3	3
2675	B:B:R134	B:B:S136	2.64	Yes	No	3	3	4
2676	B:B:L139	B:B:R137	3.64	Yes	No	0	9	5
2677	B:B:I171	B:B:R137	2.51	Yes	No	0	6	5
2678	B:B:G174	B:B:R137	3	No	No	0	4	5
2679	B:B:L139	B:B:W169	12.53	Yes	Yes	0	9	8
2680	B:B:A140	B:B:G141	1.95	No	No	0	5	5
2681	B:B:H142	B:B:L146	2.57	Yes	No	3	9	7
2682	B:B:H142	B:B:T159	2.74	Yes	Yes	3	9	9
2683	B:B:H142	B:B:S161	13.95	Yes	Yes	3	9	9
2684	B:B:D163	B:B:H142	12.61	Yes	Yes	3	9	9
2685	B:B:H142	B:B:T165	5.48	Yes	No	3	9	7
2686	B:B:A167	B:B:H142	2.93	No	Yes	0	4	9
2687	B:B:G144	B:B:T143	3.64	Yes	No	3	8	5
2688	B:B:D163	B:B:T143	8.67	Yes	No	3	9	5
2689	B:B:G144	B:B:S161	3.71	Yes	Yes	3	8	9
2690	B:B:D163	B:B:G144	5.03	Yes	Yes	3	9	8
2691	B:B:G162	B:B:Y145	7.24	No	Yes	3	9	8
2692	B:B:D186	B:B:Y145	9.2	Yes	Yes	3	9	8
2693	B:B:L146	B:B:T159	2.95	No	Yes	3	7	9
2694	B:B:C148	B:B:R150	4.18	No	Yes	6	6	6
2695	B:B:C148	B:B:L190	3.17	No	Yes	6	6	5
2696	B:B:C149	B:B:T159	3.38	No	Yes	3	8	9
2697	B:B:L190	B:B:R150	2.43	Yes	Yes	6	5	6
2698	B:B:L192	B:B:R150	2.43	No	Yes	0	5	6
2699	B:B:F151	B:B:I157	5.02	Yes	Yes	3	9	7
2700	B:B:F151	B:B:I171	3.77	Yes	Yes	3	9	6
2701	B:B:D153	B:B:L152	4.07	No	Yes	6	5	3
2702	B:B:L152	B:B:Q156	9.32	Yes	No	6	3	5
2703	B:B:L152	B:B:V158	4.47	Yes	No	6	3	5
2704	B:B:L152	B:B:L192	8.3	Yes	No	0	3	5
2705	B:B:L152	B:B:T196	4.42	Yes	No	0	3	1
2706	B:B:L152	B:B:V213	2.98	Yes	No	0	3	4
2707	B:B:D153	B:B:Q156	14.36	No	No	6	5	5
2708	B:B:I171	B:B:N155	4.25	Yes	No	0	6	3
2709	B:B:E172	B:B:N155	7.89	No	No	0	6	3
2710	B:B:L168	B:B:Q156	2.66	Yes	No	6	6	5
2711	B:B:I157	B:B:T159	3.04	Yes	Yes	3	7	9
2712	B:B:I157	B:B:W169	3.52	Yes	Yes	3	7	8
2713	B:B:L190	B:B:V158	2.98	Yes	No	6	5	5
2714	B:B:F199	B:B:V158	3.93	Yes	No	6	9	5
2715	B:B:T159	B:B:W169	8.49	Yes	Yes	3	9	8
2716	B:B:C166	B:B:S160	5.16	Yes	Yes	6	8	6
2717	B:B:S160	B:B:V187	6.46	Yes	Yes	6	6	9
2718	B:B:L190	B:B:S160	6.01	Yes	Yes	6	5	6
2719	B:B:G162	B:B:S161	3.71	No	Yes	3	9	9
2720	B:B:D163	B:B:S161	8.83	Yes	Yes	3	9	9
2721	B:B:D186	B:B:G162	6.71	Yes	No	3	9	9
2722	B:B:D163	B:B:T165	11.56	Yes	No	3	9	7
2723	B:B:G185	B:B:T164	3.64	No	No	0	5	6
2724	B:B:T165	B:B:T181	3.14	No	No	0	7	2
2725	B:B:C166	B:B:F180	2.79	Yes	Yes	6	8	7
2726	B:B:C166	B:B:V187	5.12	Yes	Yes	6	8	9
2727	B:B:C166	B:B:F199	4.19	Yes	Yes	6	8	9
2728	B:B:C166	B:B:S201	3.44	Yes	Yes	6	8	9
2729	B:B:L168	B:B:T177	4.42	Yes	No	6	6	4
2730	B:B:L168	B:B:T178	2.95	Yes	Yes	6	6	4
2731	B:B:F180	B:B:L168	2.44	Yes	Yes	6	7	6
2732	B:B:Q176	B:B:W169	6.57	No	Yes	0	4	8
2733	B:B:D170	B:B:T173	8.67	No	No	0	9	5
2734	B:B:D170	B:B:T177	5.78	No	No	0	9	4
2735	B:B:G174	B:B:T173	1.82	No	No	0	4	5
2736	B:B:Q175	B:B:T173	4.25	No	No	0	4	5
2737	B:B:Q176	B:B:T179	5.67	No	No	0	4	4
2738	B:B:T177	B:B:T178	4.71	No	Yes	6	4	4
2739	B:B:F180	B:B:T178	6.49	Yes	Yes	6	7	4
2740	B:B:G216	B:B:T178	1.82	No	Yes	6	4	4
2741	B:B:F180	B:B:F199	8.57	Yes	Yes	6	7	9
2742	B:B:F180	B:B:W211	14.03	Yes	Yes	6	7	8
2743	B:B:F180	B:B:V213	2.62	Yes	No	0	7	4
2744	B:B:F180	B:B:G216	3.01	Yes	No	6	7	4
2745	B:B:G182	B:B:T181	3.64	No	No	0	6	2
2746	B:B:G182	G:G:K14	3.49	No	No	0	6	4
2747	B:B:H183	B:B:V187	5.54	Yes	Yes	6	9	9
2748	B:B:H183	B:B:S201	2.79	Yes	Yes	6	9	9
2749	B:B:A203	B:B:H183	8.78	No	Yes	6	8	9
2750	B:B:D205	B:B:H183	2.52	Yes	Yes	6	9	9
2751	B:B:H183	B:B:S207	2.79	Yes	No	0	9	5
2752	B:B:H183	B:B:K209	14.41	Yes	Yes	6	9	6
2753	B:B:H183	B:B:W211	3.17	Yes	Yes	6	9	8
2754	B:B:D205	B:B:T184	10.12	Yes	No	0	9	3
2755	B:B:C204	B:B:G185	1.96	Yes	No	0	7	5
2756	B:B:D205	B:B:G185	5.03	Yes	No	0	9	5
2757	B:B:C204	B:B:D186	4.67	Yes	Yes	3	7	9
2758	B:B:S201	B:B:V187	3.23	Yes	Yes	6	9	9
2759	B:B:A203	B:B:V187	3.39	No	Yes	6	8	9
2760	B:B:I232	B:B:S189	3.1	Yes	No	0	8	7
2761	B:B:F199	B:B:L190	6.09	Yes	Yes	6	9	5
2762	B:B:F234	B:B:S191	5.28	Yes	No	0	5	8
2763	B:B:F199	B:B:L192	2.44	Yes	No	0	9	5
2764	B:B:A193	B:B:P194	1.87	No	No	3	4	4
2765	B:B:A193	B:B:D195	3.09	No	No	0	4	5
2766	B:B:A193	B:B:F234	5.55	No	Yes	3	4	5
2767	B:B:F234	B:B:P194	5.78	Yes	No	3	5	4
2768	B:B:G238	B:B:P194	4.06	No	No	3	7	4
2769	B:B:D195	B:B:R197	14.29	No	No	0	5	5
2770	B:B:L198	B:B:L210	4.15	No	Yes	3	3	5
2771	B:B:D212	B:B:L198	5.43	Yes	No	3	9	3
2772	B:B:L198	B:B:R219	2.43	No	Yes	3	3	5
2773	B:B:F199	B:B:W211	12.03	Yes	Yes	6	9	8
2774	B:B:L210	B:B:V200	4.47	Yes	Yes	3	5	6
2775	B:B:I232	B:B:V200	4.61	Yes	Yes	3	8	6
2776	B:B:F234	B:B:V200	3.93	Yes	Yes	3	5	6
2777	B:B:F241	B:B:V200	11.8	Yes	Yes	3	6	6
2778	B:B:S201	B:B:W211	4.94	Yes	Yes	6	9	8
2779	B:B:A208	B:B:G202	1.95	No	No	0	6	6
2780	B:B:G202	B:B:I229	3.53	No	Yes	0	6	7
2781	B:B:A203	B:B:D205	3.09	No	Yes	6	8	9
2782	B:B:C204	B:B:D228	4.67	Yes	Yes	3	7	9
2783	B:B:A208	B:B:F241	2.77	No	Yes	0	6	6
2784	B:B:K209	B:B:W211	10.44	Yes	Yes	6	6	8
2785	B:B:C218	B:B:K209	9.7	No	Yes	6	5	6
2786	B:B:K209	B:B:T221	9.01	Yes	No	0	6	7
2787	B:B:L210	B:B:R219	4.86	Yes	Yes	3	5	5
2788	B:B:L210	B:B:Q220	5.32	Yes	Yes	3	5	7
2789	B:B:L210	B:B:L255	6.92	Yes	Yes	3	5	6
2790	B:B:C218	B:B:W211	5.22	No	Yes	6	5	8
2791	B:B:D212	B:B:E215	22.09	Yes	No	0	9	3
2792	B:B:D212	B:B:R219	9.53	Yes	Yes	3	9	5
2793	B:B:E215	B:B:M217	8.12	No	No	0	3	3
2794	B:B:C218	G:G:Q18	7.63	No	No	0	5	9
2795	B:B:Q220	B:B:R219	3.5	Yes	Yes	3	7	5
2796	B:B:F222	B:B:Q220	10.54	Yes	Yes	3	8	7
2797	B:B:L255	B:B:Q220	2.66	Yes	Yes	3	6	7
2798	B:B:D258	B:B:Q220	7.83	Yes	Yes	3	7	7
2799	B:B:Q220	G:G:E22	3.82	Yes	Yes	3	7	9
2800	B:B:Q220	G:G:I25	2.74	Yes	No	0	7	2
2801	B:B:T221	G:G:E22	8.47	No	Yes	0	7	9
2802	B:B:F222	B:B:F241	6.43	Yes	Yes	3	8	6
2803	B:B:F222	B:B:F253	13.93	Yes	Yes	3	8	6
2804	B:B:D258	B:B:F222	9.55	Yes	Yes	3	7	8
2805	B:B:F253	B:B:G224	3.01	Yes	No	0	6	6
2806	B:B:H225	B:B:I229	5.3	Yes	Yes	3	9	7
2807	B:B:H225	B:B:T243	6.85	Yes	Yes	3	9	8
2808	B:B:H225	B:B:S245	15.34	Yes	Yes	3	9	9
2809	B:B:D247	B:B:H225	10.08	Yes	Yes	3	9	9
2810	B:B:H225	B:B:T249	2.74	Yes	Yes	3	9	6
2811	B:B:H225	B:B:R251	18.05	Yes	Yes	3	9	8
2812	B:B:D247	B:B:E226	14.29	Yes	No	0	9	3
2813	B:B:D228	B:B:S227	2.94	Yes	No	3	9	6
2814	B:B:D246	B:B:S227	8.83	Yes	No	3	9	6
2815	B:B:D247	B:B:S227	2.94	Yes	No	3	9	6
2816	B:B:D228	B:B:D246	11.98	Yes	Yes	3	9	9
2817	B:B:I229	B:B:T243	3.04	Yes	Yes	3	7	8
2818	B:B:I229	B:B:S245	3.1	Yes	Yes	3	7	9
2819	B:B:D246	B:B:N230	6.73	Yes	No	0	9	9
2820	B:B:A231	B:B:G244	1.95	No	Yes	55	5	5
2821	B:B:A231	B:B:V276	3.39	No	No	55	5	6
2822	B:B:F241	B:B:I232	5.02	Yes	Yes	3	6	8
2823	B:B:I232	B:B:T243	3.04	Yes	Yes	3	8	8
2824	B:B:C233	B:B:V276	5.12	No	No	0	3	6
2825	B:B:C233	B:B:F278	4.19	No	Yes	0	3	7
2826	B:B:F234	B:B:G238	3.01	Yes	No	3	5	7
2827	B:B:F234	B:B:F241	3.22	Yes	Yes	3	5	6
2828	B:B:F234	B:B:L255	3.65	Yes	Yes	3	5	6
2829	B:B:F235	B:B:P236	8.67	Yes	Yes	3	6	7
2830	B:B:F235	B:B:N237	12.08	Yes	Yes	3	6	5
2831	B:B:A240	B:B:F235	4.16	No	Yes	3	6	6
2832	B:B:F235	B:B:F278	6.43	Yes	Yes	3	6	7
2833	B:B:F235	B:B:G282	6.02	Yes	No	3	6	9
2834	B:B:F235	G:G:L37	13.4	Yes	No	3	6	7
2835	B:B:F235	G:G:Y40	6.19	Yes	Yes	3	6	6
2836	B:B:F278	B:B:P236	4.33	Yes	Yes	3	7	7
2837	B:B:G282	B:B:P236	4.06	No	Yes	3	9	7
2838	B:B:P236	G:G:Y40	5.56	Yes	Yes	3	7	6
2839	B:B:G238	B:B:N237	3.39	No	Yes	3	7	5
2840	B:B:N237	B:B:N239	6.81	Yes	No	0	5	2
2841	B:B:N237	G:G:L37	4.12	Yes	No	3	5	7
2842	B:B:N237	G:G:Y40	8.14	Yes	Yes	3	5	6
2843	B:B:N239	B:B:R256	14.46	No	Yes	0	2	9
2844	B:B:A240	G:G:L37	4.73	No	No	3	6	7
2845	B:B:F241	B:B:T243	3.89	Yes	Yes	3	6	8
2846	B:B:F241	B:B:F253	8.57	Yes	Yes	3	6	6
2847	B:B:F241	B:B:L255	2.44	Yes	Yes	3	6	6
2848	B:B:A242	B:B:F278	2.77	No	Yes	3	4	7
2849	B:B:A242	B:B:L285	3.15	No	No	3	4	6
2850	B:B:F253	B:B:T243	7.78	Yes	Yes	3	6	8
2851	B:B:C250	B:B:G244	3.92	No	Yes	0	8	5
2852	B:B:G244	B:B:I273	3.53	Yes	No	0	5	6
2853	B:B:G244	B:B:V276	1.84	Yes	No	55	5	6
2854	B:B:D246	B:B:S245	4.42	Yes	Yes	3	9	9
2855	B:B:D247	B:B:S245	10.31	Yes	Yes	3	9	9
2856	B:B:D247	B:B:T249	5.78	Yes	Yes	3	9	6
2857	B:B:R251	B:B:T249	6.47	Yes	Yes	3	8	6
2858	B:B:S265	B:B:T249	4.8	No	Yes	0	2	6
2859	B:B:F253	B:B:R251	2.14	Yes	Yes	3	6	8
2860	B:B:E260	B:B:R251	10.47	No	Yes	3	6	8
2861	B:B:R251	B:B:T263	6.47	Yes	No	3	8	1
2862	B:B:L252	B:B:L261	5.54	No	Yes	3	7	5
2863	B:B:L252	B:B:Y264	7.03	No	Yes	3	7	5
2864	B:B:E260	B:B:F253	5.83	No	Yes	3	6	6
2865	B:B:D254	B:B:R256	7.15	Yes	Yes	3	9	9
2866	B:B:A257	B:B:D254	4.63	No	Yes	0	7	9
2867	B:B:D254	B:B:L261	2.71	Yes	Yes	3	9	5
2868	B:B:D254	G:G:A33	6.18	Yes	No	3	9	7
2869	B:B:R256	G:G:I28	8.77	Yes	No	0	9	4
2870	B:B:R256	G:G:A33	4.15	Yes	No	3	9	7
2871	B:B:R256	G:G:D36	5.96	Yes	No	0	9	5
2872	B:B:D258	G:G:E22	2.6	Yes	Yes	3	7	9
2873	B:B:D258	G:G:R27	8.34	Yes	No	0	7	8
2874	B:B:E260	B:B:T263	4.23	No	No	3	6	1
2875	B:B:L261	G:G:V30	2.98	Yes	No	0	5	8
2876	B:B:M262	B:B:Y264	5.99	Yes	Yes	3	4	5
2877	B:B:A302	B:B:M262	3.22	No	Yes	3	2	4
2878	B:B:L285	B:B:Y264	2.34	No	Yes	3	6	5
2879	B:B:A299	B:B:Y264	4	No	Yes	0	5	5
2880	B:B:A302	B:B:Y264	2.67	No	Yes	3	2	5
2881	B:B:H266	B:B:N268	12.75	No	No	19	4	4
2882	B:B:H266	B:B:I269	3.98	No	Yes	19	4	4
2883	B:B:H266	B:B:R304	6.77	No	No	19	4	5
2884	B:B:I269	B:B:N268	7.08	Yes	No	19	4	4
2885	B:B:I269	B:B:Y289	3.63	Yes	Yes	19	4	7
2886	B:B:I269	B:B:N295	4.25	Yes	Yes	19	4	6
2887	B:B:C271	B:B:D291	7.78	No	No	0	5	8
2888	B:B:I273	B:B:Y289	13.3	No	Yes	0	6	7
2889	B:B:R314	B:B:T274	11.64	Yes	No	0	8	8
2890	B:B:G288	B:B:S275	1.86	No	No	0	7	8
2891	B:B:L318	B:B:S275	7.51	Yes	No	0	6	8
2892	B:B:L286	B:B:S277	4.5	Yes	Yes	14	7	5
2893	B:B:L318	B:B:S277	3	Yes	Yes	14	6	5
2894	B:B:G319	B:B:S277	1.86	No	Yes	0	5	5
2895	B:B:S277	B:B:V320	4.85	Yes	No	0	5	7
2896	B:B:F278	B:B:G282	6.02	Yes	No	3	7	9
2897	B:B:F278	B:B:L285	15.83	Yes	No	3	7	6
2898	B:B:L284	B:B:S279	4.5	Yes	No	0	5	9
2899	B:B:L286	B:B:S279	4.5	Yes	No	0	7	9
2900	B:B:S279	G:G:L50	3	No	No	0	9	9
2901	B:B:G324	B:B:K280	3.49	Yes	No	0	9	1
2902	B:B:K280	G:G:D48	6.91	No	Yes	0	1	9
2903	B:B:S281	G:G:C41	3.44	No	No	0	9	7
2904	B:B:S281	G:G:D48	5.89	No	Yes	0	9	9
2905	B:B:D298	B:B:R283	2.38	Yes	Yes	26	9	9
2906	B:B:L300	B:B:R283	9.72	Yes	Yes	0	6	9
2907	B:B:K301	B:B:R283	4.95	Yes	Yes	26	5	9
2908	B:B:R283	G:G:L51	6.07	Yes	Yes	26	9	6
2909	B:B:L284	B:B:V296	5.96	Yes	Yes	0	5	5
2910	B:B:L284	G:G:L51	6.92	Yes	Yes	0	5	6
2911	B:B:L286	B:B:V296	4.47	Yes	Yes	0	7	5
2912	B:B:L286	B:B:L318	5.54	Yes	Yes	14	7	6
2913	B:B:L286	B:B:V327	4.47	Yes	No	14	7	6
2914	B:B:A287	B:B:Y289	4	No	Yes	19	6	7
2915	B:B:A287	B:B:W297	2.59	No	Yes	19	6	8
2916	B:B:C294	B:B:G288	3.92	No	No	0	5	7
2917	B:B:G288	B:B:V315	1.84	No	No	0	7	7
2918	B:B:D291	B:B:Y289	2.3	No	Yes	0	8	7
2919	B:B:N295	B:B:Y289	13.96	Yes	Yes	19	6	7
2920	B:B:W297	B:B:Y289	7.72	Yes	Yes	19	8	7
2921	B:B:D290	B:B:R314	19.06	No	Yes	3	6	8
2922	B:B:D291	B:B:N293	8.08	No	No	0	8	5
2923	B:B:F292	B:B:N313	2.42	No	No	0	4	7
2924	B:B:N293	B:B:V307	5.91	No	No	0	5	3
2925	B:B:A309	B:B:N293	3.13	No	No	0	3	5
2926	B:B:C294	B:B:L308	4.76	No	No	0	5	7
2927	B:B:C294	B:B:L318	3.17	No	Yes	0	5	6
2928	B:B:N295	B:B:W297	5.65	Yes	Yes	19	6	8
2929	B:B:N295	B:B:R304	9.64	Yes	No	19	6	5
2930	B:B:N295	B:B:V307	2.96	Yes	No	0	6	3
2931	B:B:G306	B:B:V296	1.84	No	Yes	0	4	5
2932	B:B:R304	B:B:W297	2	No	Yes	19	5	8
2933	B:B:D298	B:B:K301	8.3	Yes	Yes	26	9	5
2934	B:B:D298	B:B:D303	10.65	Yes	No	26	9	2
2935	B:B:L300	G:G:M38	2.83	Yes	No	0	6	4
2936	B:B:L300	G:G:C41	4.76	Yes	No	0	6	7
2937	B:B:D303	B:B:K301	5.53	No	Yes	26	2	5
2938	B:B:G306	B:B:V307	1.84	No	No	0	4	3
2939	B:B:L308	B:B:W339	17.08	No	Yes	0	7	9
2940	B:B:A309	B:B:G310	1.95	No	No	0	3	5
2941	B:B:H311	B:B:V315	4.15	Yes	No	14	9	7
2942	B:B:H311	B:B:T329	5.48	Yes	Yes	14	9	8
2943	B:B:G330	B:B:H311	3.18	No	Yes	0	5	9
2944	B:B:H311	B:B:S331	12.55	Yes	No	14	9	9
2945	B:B:D333	B:B:H311	8.82	Yes	Yes	14	9	9
2946	B:B:H311	B:B:K337	14.41	Yes	Yes	14	9	6
2947	B:B:D312	B:B:D333	10.65	No	Yes	0	5	9
2948	B:B:N313	B:B:W332	7.91	No	Yes	0	7	9
2949	B:B:R314	B:B:S316	6.59	Yes	No	3	8	9
2950	B:B:R314	B:B:W332	14.99	Yes	Yes	3	8	9
2951	B:B:S331	B:B:V315	6.46	No	No	14	9	7
2952	B:B:S316	B:B:W332	8.65	No	Yes	3	9	9
2953	B:B:C317	B:B:G330	3.92	No	No	0	7	5
2954	B:B:L318	B:B:T329	2.95	Yes	Yes	14	6	8
2955	B:B:G324	B:B:V320	1.84	Yes	No	0	9	7
2956	B:B:D323	B:B:T321	7.23	No	Yes	5	7	7
2957	B:B:G324	B:B:T321	1.82	Yes	Yes	0	9	7
2958	B:B:D323	B:B:M325	8.32	No	Yes	5	7	5
2959	B:B:G324	G:G:P49	2.03	Yes	Yes	0	9	7
2960	B:B:M325	G:G:P49	3.35	Yes	Yes	5	5	7
2961	B:B:M325	G:G:V54	3.04	Yes	Yes	5	5	6
2962	B:B:M325	G:G:P60	5.03	Yes	Yes	5	5	9
2963	B:B:A326	G:G:F61	2.77	No	Yes	0	7	8
2964	B:B:T329	B:B:V327	3.17	Yes	No	14	8	6
2965	B:B:V327	B:B:W339	2.45	No	Yes	14	6	9
2966	B:B:T329	B:B:W339	9.7	Yes	Yes	14	8	9
2967	B:B:G330	B:B:L336	3.42	No	Yes	0	5	7
2968	B:B:D333	B:B:S331	4.42	Yes	No	14	9	9
2969	B:B:D333	B:B:F335	8.36	Yes	No	14	9	4
2970	B:B:K337	B:B:W339	8.12	Yes	Yes	14	6	9
2971	B:B:I338	G:G:F61	3.77	Yes	Yes	5	5	8
2972	G:G:I9	G:G:R13	5.01	No	No	0	2	6
2973	G:G:L15	G:G:Q11	6.65	Yes	Yes	34	2	3
2974	G:G:E17	G:G:R13	10.47	No	No	0	6	6
2975	G:G:L19	G:G:Q18	2.66	No	No	0	9	9
2976	G:G:E22	G:G:Q18	7.65	Yes	No	0	9	9
2977	G:G:K20	G:G:N24	2.8	No	No	0	6	1
2978	G:G:I25	G:G:R27	6.26	No	No	0	2	8
2979	G:G:I28	G:G:K32	2.91	No	No	0	4	5
2980	G:G:D36	G:G:K32	4.15	No	No	0	5	5
2981	G:G:E42	G:G:M38	6.77	No	No	0	1	4
2982	G:G:H44	G:G:Y40	17.42	No	Yes	0	6	6
2983	G:G:C41	G:G:E42	3.04	No	No	0	7	1
2984	G:G:A43	G:G:H44	2.93	No	No	0	4	6
2985	G:G:E47	G:G:K46	4.05	No	No	0	3	1
2986	G:G:D48	G:G:P49	4.83	Yes	Yes	0	9	7
2987	G:G:D48	G:G:L51	8.14	Yes	Yes	0	9	6
2988	G:G:P49	G:G:V54	3.53	Yes	Yes	5	7	6
2989	G:G:E58	G:G:V54	2.85	No	Yes	0	5	6
2990	G:G:N59	G:G:V54	5.91	No	Yes	5	9	6
2991	G:G:E58	G:G:P55	4.72	No	No	0	5	5
2992	G:G:N59	G:G:P60	4.89	No	Yes	5	9	9
2993	G:G:F61	G:G:N59	2.42	Yes	No	5	8	9
2994	G:G:F61	G:G:P60	5.78	Yes	Yes	5	8	9
2995	H:H:?1	H:H:?2	33.04	Yes	No	2	0	0
2996	H:H:?3	H:H:?4	35.24	Yes	No	1	0	0
2997	A:A:A366	A:A:C365	1.81	No	Yes	0	9	8
2998	R:R:P407	R:R:S303	1.78	No	No	0	1	3
2999	G:G:P55	G:G:S57	1.78	No	No	0	5	6
3000	S:S:G94	S:S:I33	1.76	No	No	0	9	5
3001	S:S:G613	S:S:I669	1.76	No	Yes	0	8	8
3002	S:S:G632	S:S:I635	1.76	No	No	0	1	4
3003	R:R:G632	R:R:I635	1.76	No	Yes	0	1	4
3004	B:B:P107	B:B:T65	1.75	No	No	0	6	1
3005	G:G:P53	G:G:T52	1.75	No	No	0	8	4
3006	S:S:G518	S:S:K517	1.74	No	No	0	3	1
3007	S:S:G632	S:S:K636	1.74	No	No	0	1	4
3008	R:R:G483	R:R:K177	1.74	No	No	0	7	7
3009	S:S:C585	S:S:S591	1.72	Yes	Yes	10	9	8
3010	S:S:C731	S:S:S693	1.72	No	No	0	5	9
3011	R:R:C598	R:R:S591	1.72	Yes	Yes	16	9	8
3012	R:R:C660	R:R:S663	1.72	No	No	0	7	6
3013	R:R:C661	R:R:S687	1.72	No	No	0	7	6
3014	S:S:A86	S:S:S84	1.71	No	No	0	3	6
3015	S:S:A300	S:S:S301	1.71	No	No	0	6	5
3016	S:S:A321	S:S:S301	1.71	Yes	No	0	5	5
3017	S:S:A321	S:S:S490	1.71	Yes	No	0	5	8
3018	S:S:C694	S:S:V728	1.71	Yes	No	0	6	7
3019	R:R:A86	R:R:S84	1.71	No	No	0	3	6
3020	R:R:A300	R:R:S301	1.71	No	No	0	6	5
3021	R:R:G501	R:R:L496	1.71	No	No	0	5	3
3022	R:R:A579	R:R:S574	1.71	No	No	0	7	8
3023	R:R:A581	R:R:S580	1.71	No	No	0	4	4
3024	R:R:G623	R:R:L622	1.71	No	No	0	6	3
3025	R:R:A683	R:R:S664	1.71	No	No	0	5	6
3026	R:R:G720	R:R:L723	1.71	No	No	0	7	7
3027	A:A:A243	A:A:S286	1.71	No	No	0	8	8
3028	S:S:A45	S:S:V58	1.7	No	No	0	1	1
3029	S:S:A107	S:S:V149	1.7	No	No	0	7	4
3030	S:S:A107	S:S:V153	1.7	No	Yes	0	7	6
3031	S:S:G346	S:S:N345	1.7	No	Yes	0	3	8
3032	S:S:A840	S:S:V817	1.7	No	No	0	9	9
3033	R:R:G346	R:R:N345	1.7	No	Yes	0	3	8
3034	R:R:G474	R:R:N471	1.7	No	Yes	0	5	6
3035	A:A:G52	A:A:N292	1.7	No	Yes	0	9	9
3036	B:B:A28	G:G:V30	1.7	No	No	0	4	8
3037	S:S:C236	S:S:T560	1.69	Yes	No	2	9	4
3038	S:S:C561	S:S:T560	1.69	Yes	No	2	9	4
3039	R:R:C236	R:R:T560	1.69	Yes	No	1	9	4
3040	R:R:I503	R:R:P308	1.69	Yes	No	0	4	2
3041	R:R:C561	R:R:T560	1.69	Yes	No	1	9	4
3042	S:S:A746	S:S:T745	1.68	No	No	0	6	4
3043	R:R:D570	R:R:G571	1.68	No	No	0	5	7
3044	R:R:A746	R:R:T745	1.68	No	No	0	6	4
3045	A:A:D354	A:A:G355	1.68	No	No	0	3	2
3046	B:B:D118	B:B:G116	1.68	No	No	0	9	9
3047	B:B:D290	B:B:G272	1.68	No	No	0	6	4
3048	S:S:K47	S:S:P55	1.67	No	Yes	0	2	6
3049	R:R:K863	R:R:P864	1.67	No	No	0	7	8
3050	S:S:E564	S:S:G553	1.64	No	No	0	6	6
3051	S:S:C781	S:S:I777	1.64	No	No	0	7	8
3052	R:R:G43	R:R:Q245	1.64	No	Yes	0	2	4
3053	R:R:E564	R:R:G553	1.64	No	No	0	6	6
3054	R:R:C851	R:R:I813	1.64	No	No	0	8	8
3055	A:A:E35	A:A:G34	1.64	No	No	0	4	5
3056	S:S:N867	S:S:P864	1.63	No	No	0	9	8
3057	R:R:S244	R:R:S247	1.63	No	No	0	4	2
3058	R:R:S497	R:R:S502	1.63	Yes	No	0	3	4
3059	B:B:S147	B:B:S160	1.63	No	Yes	0	9	6
3060	S:S:A116	S:S:I135	1.62	No	Yes	0	6	4
3061	R:R:A45	R:R:I61	1.62	No	No	0	1	2
3062	R:R:S403	R:R:V404	1.62	No	Yes	0	2	4
3063	B:B:I18	G:G:A23	1.62	No	No	0	7	8
3064	B:B:I33	G:G:A34	1.62	No	No	0	3	6
3065	B:B:I33	G:G:A35	1.62	No	No	0	3	2
3066	R:R:D410	R:R:P407	1.61	No	No	0	6	1
3067	B:B:A11	B:B:K15	1.61	No	No	0	5	6
3068	S:S:V737	S:S:V740	1.6	No	No	0	3	3
3069	R:R:T828	S:S:S827	1.6	Yes	No	0	8	8
3070	R:R:S827	R:R:T828	1.6	No	Yes	0	8	8
3071	S:S:T617	S:S:V621	1.59	No	No	0	5	4
3072	S:S:C731	S:S:L730	1.59	No	No	0	5	3
3073	R:R:T828	R:R:V833	1.59	Yes	No	0	8	6
3074	B:B:L30	G:G:A34	1.58	Yes	No	0	5	6
3075	S:S:E610	S:S:P611	1.57	Yes	No	0	7	4
3076	R:R:E799	R:R:P798	1.57	No	No	0	8	9
3077	S:S:A645	S:S:N800	1.56	No	Yes	0	9	7
3078	A:A:A19	B:B:N88	1.56	No	Yes	0	5	7
3079	A:A:A20	B:B:N88	1.56	No	Yes	0	3	7
3080	S:S:I139	S:S:S137	1.55	Yes	No	0	5	4
3081	S:S:I292	S:S:S531	1.55	Yes	No	0	7	4
3082	R:R:I401	R:R:S402	1.55	No	No	0	7	4
3083	S:S:I624	S:S:V621	1.54	No	No	0	5	4
3084	S:S:I741	S:S:V740	1.54	No	No	0	4	3
3085	R:R:I736	R:R:V737	1.54	No	No	0	5	3
3086	R:R:K106	R:R:S57	1.53	Yes	No	0	4	1
3087	B:B:M262	B:B:S31	1.53	Yes	No	0	4	1
3088	G:G:K32	G:G:S31	1.53	No	No	0	5	9
3089	S:S:C131	S:S:E133	1.52	No	No	0	3	5
3090	S:S:C482	S:S:E481	1.52	No	No	0	7	4
3091	S:S:K506	S:S:V504	1.52	No	No	0	5	3
3092	G:G:A12	G:G:Q11	1.52	No	Yes	0	5	3
3093	S:S:F479	S:S:G483	1.51	Yes	No	0	8	7
3094	R:R:F612	R:R:G613	1.51	No	No	0	8	8
3095	A:A:A316	A:A:E309	1.51	No	No	0	2	4
3096	A:A:A316	A:A:E314	1.51	No	No	0	2	6
3097	R:R:L123	R:R:S122	1.5	No	No	0	5	3
3098	R:R:G720	R:R:R701	1.5	No	Yes	0	7	8
3099	A:A:L266	A:A:S250	1.5	No	No	0	8	6
3100	S:S:N400	S:S:S403	1.49	No	No	0	4	2
3101	R:R:N592	R:R:S597	1.49	No	No	0	7	1
3102	G:G:L15	G:G:V16	1.49	Yes	No	0	2	7
3103	S:S:D50	S:S:S53	1.47	Yes	No	0	3	3
3104	S:S:D121	S:S:S122	1.47	No	No	0	3	3
3105	S:S:I819	S:S:I822	1.47	No	No	0	6	7
3106	R:R:I819	S:S:I839	1.47	No	No	0	6	7
3107	R:R:D215	R:R:S244	1.47	Yes	No	0	6	4
3108	R:R:L618	R:R:T617	1.47	No	Yes	0	4	5
3109	R:R:I819	R:R:I822	1.47	No	Yes	0	6	7
3110	B:B:D322	B:B:S67	1.47	No	No	0	1	5
3111	G:G:L51	G:G:T52	1.47	Yes	No	0	6	4
3112	A:A:D16	A:A:V12	1.46	No	No	0	4	1
3113	B:B:A206	B:B:H225	1.46	No	Yes	0	4	9
3114	R:R:I452	R:R:K453	1.45	No	No	0	3	2
3115	S:S:P393	S:S:R392	1.44	No	No	0	1	1
3116	R:R:P393	R:R:R392	1.44	No	No	0	1	1
3117	B:B:Q75	B:B:S98	1.44	Yes	No	0	9	8
3118	S:S:E871	S:S:V872	1.43	No	No	0	5	4
3119	R:R:I786	R:R:L782	1.43	No	No	0	4	4
3120	G:G:E17	G:G:V16	1.43	No	No	0	6	7
3121	S:S:G720	S:S:W719	1.41	No	No	0	7	6
3122	R:R:L770	R:R:M771	1.41	No	No	0	3	3
3123	A:A:M25	A:A:N29	1.4	No	No	0	4	4
3124	A:A:K28	A:A:N29	1.4	No	No	0	4	4
3125	B:B:K301	B:B:N35	1.4	Yes	No	0	5	1
3126	R:R:A826	S:S:F832	1.39	No	Yes	0	5	5
3127	B:B:H54	B:B:S334	1.39	Yes	No	0	9	4
3128	S:S:L703	S:S:L704	1.38	No	No	0	7	8
3129	R:R:L723	R:R:L726	1.38	No	No	0	7	4
3130	S:S:L703	S:S:N700	1.37	No	No	0	7	7
3131	A:A:E32	A:A:K28	1.35	No	No	0	3	4
3132	S:S:L723	S:S:Q724	1.33	No	Yes	0	7	8
3133	R:R:L394	R:R:Q361	1.33	No	No	0	1	1
3134	S:S:E649	S:S:N647	1.31	No	No	0	7	9
3135	S:S:F792	S:S:T808	1.3	No	No	0	8	9
3136	R:R:D575	R:R:E576	1.3	No	No	0	8	3
3137	S:S:R866	S:S:T868	1.29	No	No	0	6	6
3138	R:R:E229	R:R:E232	1.27	Yes	No	0	5	4
3139	B:B:E10	B:B:Q13	1.27	Yes	No	0	8	1
3140	R:R:S534	R:R:W530	1.24	No	Yes	0	4	8
3141	R:R:E353	R:R:H359	1.23	No	No	0	7	4
3142	S:S:F619	S:S:L618	1.22	No	No	0	3	4
3143	S:S:F619	S:S:L842	1.22	No	No	0	3	9
3144	S:S:F625	S:S:L626	1.22	No	No	0	3	4
3145	R:R:F619	R:R:L842	1.22	No	Yes	0	3	9
3146	S:S:T609	S:S:W608	1.21	No	Yes	0	4	5
3147	R:R:F725	R:R:N722	1.21	Yes	No	0	5	3
3148	A:A:D223	A:A:F208	1.19	No	No	0	9	5
3149	A:A:D229	A:A:R231	1.19	No	Yes	0	8	9
3150	B:B:D212	B:B:R214	1.19	Yes	No	0	9	9
3151	R:R:L743	R:R:Y744	1.17	No	No	0	7	3
3152	R:R:N90	R:R:Y435	1.16	No	Yes	0	8	3
3153	A:A:E314	A:A:R317	1.16	No	No	0	6	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	S:S:R25	9.0975	4	2	4
2	S:S:I32	5.218	5	11	6
3	S:S:L34	3.704	5	2	7
4	S:S:G35	3.115	4	2	8
5	S:S:G36	2.7425	4	2	7
6	S:S:F38	6.10333	6	2	7
7	S:S:P39	5.265	4	2	6
8	S:S:I40	5.618	5	2	5
9	S:S:H41	6.48833	6	2	7
10	S:S:F42	11.315	4	8	3
11	S:S:D50	5.16	4	0	3
12	S:S:K52	9.69	4	17	3
13	S:S:P55	8.35	4	17	6
14	S:S:C60	5.325	4	2	7
15	S:S:Y63	7.50143	7	2	5
16	S:S:F65	6.79	6	2	2
17	S:S:R66	6.88	6	2	5
18	S:S:F68	7.09143	7	2	7
19	S:S:R69	7.3425	4	2	8
20	S:S:W70	6.24	11	2	5
21	S:S:L71	4.232	5	2	4
22	S:S:Q72	7.654	5	2	7
23	S:S:M74	4.55167	6	2	8
24	S:S:I75	5.435	4	2	4
25	S:S:F76	7.176	5	2	7
26	S:S:I78	3.42	4	2	6
27	S:S:I81	4.8675	4	2	9
28	S:S:L87	5.215	4	2	6
29	S:S:L91	6.2575	4	0	6
30	S:S:L93	3.835	4	0	9
31	S:S:Y95	8.35	5	2	8
32	S:S:R96	5.894	5	2	4
33	S:S:I97	5.08167	6	2	8
34	S:S:F98	7.875	6	2	4
35	S:S:D99	7.4725	4	2	9
36	S:S:C101	6.0625	4	2	8
37	S:S:K106	3.535	4	2	4
38	S:S:F114	4.996	5	2	5
39	S:S:K119	4.9825	4	1	3
40	S:S:L123	4.702	5	1	5
41	S:S:L125	4.505	4	1	4
42	S:S:I135	5.246	5	36	4
43	S:S:I139	3.6975	4	11	5
44	S:S:T145	5.96333	6	2	5
45	S:S:S150	4.4875	4	2	8
46	S:S:T151	4.7675	4	2	5
47	S:S:V153	4.55	5	2	6
48	S:S:N155	5.42	4	2	5
49	S:S:L157	4.534	5	2	7
50	S:S:F160	5.975	4	2	7
51	S:S:I162	3.6075	4	2	6
52	S:S:P163	3.41833	6	0	8
53	S:S:Q164	6.09	6	2	8
54	S:S:V165	3.07667	6	2	6
55	S:S:S166	3.9	4	2	9
56	S:S:Y167	6.36143	7	2	8
57	S:S:S169	4.67	4	2	8
58	S:S:S170	5.6075	4	2	7
59	S:S:R172	5.58833	6	2	4
60	S:S:L173	6.91	4	2	5
61	S:S:L174	6.495	6	2	7
62	S:S:S175	4.89	4	2	8
63	S:S:Q179	6.4425	4	2	5
64	S:S:F180	6.136	5	2	5
65	S:S:F183	6.09	8	2	8
66	S:S:R185	6.184	5	2	9
67	S:S:I187	5.042	5	2	6
68	S:S:P188	3.9875	4	2	8
69	S:S:D190	8.2525	4	2	8
70	S:S:Q193	9.728	5	2	9
71	S:S:T195	5.2825	4	2	4
72	S:S:D199	6.22	4	2	7
73	S:S:I200	3.3525	4	0	8
74	S:S:I201	3.804	5	2	6
75	S:S:F204	6.74167	6	2	7
76	S:S:W206	7.44667	6	2	9
77	S:S:W208	6.9625	8	2	9
78	S:S:V209	3.492	5	2	8
79	S:S:T211	5.685	4	2	5
80	S:S:I212	3.538	5	2	6
81	S:S:A214	2.8875	4	0	5
82	S:S:D217	3.8325	4	2	6
83	S:S:Y218	5.37125	8	2	7
84	S:S:R220	5.3375	4	2	6
85	S:S:I223	5.5625	4	2	5
86	S:S:K225	7.992	5	2	3
87	S:S:F226	3.97875	8	2	6
88	S:S:R227	8.295	4	0	4
89	S:S:E229	7.8	5	2	5
90	S:S:R233	6.034	5	2	4
91	S:S:I235	3.814	5	2	7
92	S:S:C236	3.365	4	2	9
93	S:S:D238	7.26	4	2	8
94	S:S:F239	5.07333	6	2	6
95	S:S:Q245	6.7375	4	0	4
96	S:S:V266	6.48	5	2	7
97	S:S:I267	5.4825	4	2	7
98	S:S:V268	5.5275	4	2	6
99	S:S:F270	5.49	6	2	7
100	S:S:P274	4.862	5	8	3
101	S:S:D275	3.9175	4	0	5
102	S:S:E277	4.9225	4	8	2
103	S:S:E282	6.345	4	0	6
104	S:S:I283	4.4775	4	0	4
105	S:S:R286	5.194	5	38	4
106	S:S:I292	4.1875	4	2	7
107	S:S:W293	5.994	5	2	8
108	S:S:L294	3.784	5	0	7
109	S:S:E297	7.166	5	2	8
110	S:S:W299	7.30333	6	8	7
111	S:S:I305	4.94833	6	8	4
112	S:S:Y310	6.56333	6	8	3
113	S:S:F311	9.695	4	0	3
114	S:S:F320	6.232	5	2	6
115	S:S:A321	3.395	4	0	5
116	S:S:L322	6.135	4	2	4
117	S:S:I327	4.93167	6	2	6
118	S:S:F330	6.814	5	2	8
119	S:S:R331	7.65	4	2	4
120	S:S:F333	9.7275	4	2	7
121	S:S:L334	6.82	5	2	6
122	S:S:H338	8.1875	4	2	4
123	S:S:N345	4.24833	6	2	8
124	S:S:F347	5.245	4	0	5
125	S:S:E350	6.03	4	2	5
126	S:S:F351	7.275	8	2	6
127	S:S:W352	11.41	5	2	8
128	S:S:T355	5.086	5	2	4
129	S:S:F356	9.804	5	2	8
130	S:S:I401	4.4425	4	2	7
131	S:S:P407	4.29	4	2	1
132	S:S:Y408	8.495	8	2	3
133	S:S:I409	6.072	5	2	5
134	S:S:Y411	10.9425	4	0	5
135	S:S:L414	5.4125	4	2	6
136	S:S:I416	6.79	4	2	4
137	S:S:Y418	5.53	6	2	7
138	S:S:V420	4.965	4	2	7
139	S:S:Y421	6.066	5	2	8
140	S:S:Y425	5.12667	6	2	8
141	S:S:S426	3.166	5	2	7
142	S:S:I427	4.4825	4	0	5
143	S:S:F444	3.91667	6	11	3
144	S:S:V455	3.355	4	11	4
145	S:S:W458	11.514	5	11	4
146	S:S:Q459	8.382	5	11	7
147	S:S:L461	3.698	5	11	7
148	S:S:K462	6.624	5	11	4
149	S:S:H463	7.015	4	0	5
150	S:S:L464	3.572	5	0	7
151	S:S:F469	7.352	5	2	8
152	S:S:N471	6.6825	4	2	6
153	S:S:M473	5.14	5	2	4
154	S:S:F479	4.8	6	2	8
155	S:S:D484	4.6675	4	2	8
156	S:S:Y489	4.55167	6	2	8
157	S:S:W494	7.10167	6	8	7
158	S:S:S497	3.266	5	0	3
159	S:S:Y511	5.6675	8	2	5
160	S:S:N512	4.57	4	2	4
161	S:S:V513	5.10667	6	2	3
162	S:S:Y514	6.3	4	2	4
163	S:S:L521	4.79	5	2	5
164	S:S:E525	6.1225	4	2	4
165	S:S:K527	5.235	4	40	3
166	S:S:I528	6.5425	4	2	7
167	S:S:W530	8.9975	8	2	8
168	S:S:V537	5.63	4	2	4
169	S:S:F539	5.17	4	2	1
170	S:S:C546	5.365	4	27	9
171	S:S:T550	5.5275	4	27	6
172	S:S:P559	4.335	4	2	6
173	S:S:C561	4.884	5	2	9
174	S:S:C568	3.8875	4	1	9
175	S:S:P569	4.8525	4	1	5
176	S:S:Y573	6.365	4	10	6
177	S:S:C585	4.0825	4	10	9
178	S:S:D588	6.605	4	10	6
179	S:S:W590	5.57167	6	10	6
180	S:S:S591	3.37	4	10	8
181	S:S:N592	8.0075	4	29	7
182	S:S:H595	6.8175	4	0	5
183	S:S:T596	5.93	4	29	5
184	S:S:C598	3.205	4	10	9
185	S:S:I603	4.5675	4	10	4
186	S:S:F605	7.0075	4	0	7
187	S:S:L606	3.0675	4	0	9
188	S:S:W608	4.3525	4	0	5
189	S:S:E610	3.5	4	0	7
190	S:S:F612	4.865	6	9	8
191	S:S:F634	6.4725	4	0	9
192	S:S:I642	5.71	4	0	7
193	S:S:L650	6.3625	4	7	8
194	S:S:L654	5.464	5	7	8
195	S:S:F662	7.4875	4	43	8
196	S:S:F668	8.0225	4	0	9
197	S:S:I669	3.04	4	0	8
198	S:S:P672	4.5025	4	22	9
199	S:S:C677	3.62	4	22	9
200	S:S:R680	6.778	5	0	8
201	S:S:F684	9.975	6	12	8
202	S:S:F688	6.686	5	0	8
203	S:S:V689	6.124	5	46	7
204	S:S:L690	5.375	4	0	7
205	S:S:C691	5.2925	4	7	8
206	S:S:I692	4.5575	4	12	7
207	S:S:C694	4.395	4	0	6
208	S:S:K698	3.8375	4	7	9
209	S:S:Q724	6.385	4	7	8
210	S:S:Q735	6.46833	6	46	9
211	S:S:W742	5.382	5	0	9
212	S:S:P748	5.125	4	22	9
213	S:S:Q754	5.3525	4	10	4
214	S:S:I760	4.645	4	42	5
215	S:S:I761	6.644	5	10	7
216	S:S:F762	5.9975	4	42	7
217	S:S:H766	3.74	4	0	6
218	S:S:E767	3.662	5	12	7
219	S:S:F790	3.535	4	0	7
220	S:S:N800	5.8725	4	0	7
221	S:S:E803	6.015	4	7	9
222	S:S:K805	6.2375	4	7	9
223	S:S:F806	6.082	5	7	5
224	S:S:I807	3.335	4	7	9
225	S:S:F809	5.184	5	7	9
226	S:S:F814	7.6175	4	12	9
227	S:S:W818	8.06571	7	12	9
228	S:S:F821	5.93667	6	12	9
229	S:S:Y825	7.004	5	12	9
230	S:S:F832	5.81333	6	9	5
231	S:S:E837	6.335	4	12	9
232	S:S:I841	5.83	4	12	9
233	S:S:L848	4.2625	4	7	7
234	S:S:I852	5.9575	4	7	9
235	S:S:F853	5.472	5	7	9
236	S:S:I857	4.185	4	0	8
237	R:R:Y20	6.82	6	1	2
238	R:R:G35	3.0325	4	1	8
239	R:R:G36	2.796	5	1	7
240	R:R:F38	5.32571	7	1	7
241	R:R:P39	4.864	5	1	6
242	R:R:I40	6.03	5	1	5
243	R:R:H41	7.48333	6	1	7
244	R:R:F42	11.51	4	1	3
245	R:R:L51	6.4025	4	11	6
246	R:R:P55	7.3525	4	11	6
247	R:R:Y63	7.95429	7	1	5
248	R:R:N64	8.1275	4	1	4
249	R:R:F65	7.476	5	1	2
250	R:R:R66	9.3	5	1	5
251	R:R:F68	6.94714	7	1	7
252	R:R:R69	6.4375	8	1	8
253	R:R:W70	6.30455	11	1	5
254	R:R:L71	4.04	5	1	4
255	R:R:Q72	6.658	5	1	7
256	R:R:M74	4.79333	6	1	8
257	R:R:I75	4.904	5	1	4
258	R:R:F76	5.938	5	1	7
259	R:R:L88	4.362	5	0	9
260	R:R:L93	4.204	5	0	9
261	R:R:Y95	8.838	5	1	8
262	R:R:R96	5.48333	6	1	4
263	R:R:I97	5.31167	6	1	8
264	R:R:F98	7.70667	6	1	4
265	R:R:D99	6.81	4	1	9
266	R:R:C101	5.6575	4	1	8
267	R:R:K106	2.806	5	1	4
268	R:R:E109	4.3875	4	1	5
269	R:R:L112	3.4925	4	1	5
270	R:R:F114	5.08833	6	1	5
271	R:R:Q117	5.3825	4	1	6
272	R:R:N118	5.025	4	1	4
273	R:R:K119	7.3225	4	1	3
274	R:R:L125	4.6425	4	36	4
275	R:R:V141	4.18	4	1	7
276	R:R:T145	6.37333	6	1	5
277	R:R:S150	4.0225	4	1	8
278	R:R:T151	4.2675	4	1	5
279	R:R:V153	4.92	4	1	6
280	R:R:N155	5.5275	4	1	5
281	R:R:L157	4.298	5	1	7
282	R:R:F160	5	5	1	7
283	R:R:I162	3.86	5	1	6
284	R:R:P163	4.04167	6	1	8
285	R:R:Q164	5.16833	6	1	8
286	R:R:S166	4.3625	4	1	9
287	R:R:Y167	6.23143	7	1	8
288	R:R:R172	5.395	6	2	4
289	R:R:L173	6.542	5	2	5
290	R:R:L174	7.8	4	1	7
291	R:R:Q179	7.0375	4	1	5
292	R:R:F180	5.656	5	1	5
293	R:R:F183	8.58	5	1	8
294	R:R:R185	5.17333	6	1	9
295	R:R:I187	4.382	5	1	6
296	R:R:D190	5.6875	4	1	8
297	R:R:Q193	4.08	6	1	9
298	R:R:T195	5.2725	4	1	4
299	R:R:M197	5.1825	4	1	7
300	R:R:D199	5.562	5	1	7
301	R:R:I200	3.44	4	1	8
302	R:R:I201	3.948	5	1	6
303	R:R:F204	7.35333	6	1	7
304	R:R:W206	6.10857	7	1	9
305	R:R:W208	9.41	7	1	9
306	R:R:V209	3.834	5	1	8
307	R:R:T211	5.472	5	1	5
308	R:R:D215	6.87	4	2	6
309	R:R:Y218	4.33111	9	1	7
310	R:R:R220	5.242	5	2	6
311	R:R:P221	4.17	4	2	3
312	R:R:K225	8.9025	4	0	3
313	R:R:F226	3.73286	7	1	6
314	R:R:R227	8.26	4	0	4
315	R:R:E229	6.796	5	1	5
316	R:R:R233	6.085	6	1	4
317	R:R:I235	4.3975	4	1	7
318	R:R:C236	3.8375	4	1	9
319	R:R:I237	4.3025	4	1	6
320	R:R:D238	8.5325	4	1	8
321	R:R:F239	4.54571	7	1	6
322	R:R:I243	4.075	4	1	5
323	R:R:Q245	5.065	4	0	4
324	R:R:V255	4.8075	4	1	5
325	R:R:I259	3.18	4	1	6
326	R:R:V266	4.584	5	1	7
327	R:R:I267	4.53	4	1	7
328	R:R:V268	5.6725	4	1	6
329	R:R:F270	4.50286	7	1	7
330	R:R:P274	4.1025	4	1	3
331	R:R:D275	4.315	4	1	5
332	R:R:L276	4.656	5	1	5
333	R:R:E277	4.665	4	1	2
334	R:R:L279	4.68	4	1	5
335	R:R:E282	5.57	4	20	6
336	R:R:R286	5.715	6	20	4
337	R:R:I292	4.5425	4	1	7
338	R:R:W293	4.25333	6	1	8
339	R:R:L294	3.2875	4	0	7
340	R:R:S296	4.25	4	1	8
341	R:R:W299	6.0875	8	1	7
342	R:R:L304	6.234	5	1	2
343	R:R:I305	4.5225	4	1	4
344	R:R:Y310	4.86333	6	1	3
345	R:R:F311	9.98	4	1	3
346	R:R:V313	4.444	5	1	3
347	R:R:V314	3.425	4	1	7
348	R:R:I318	2.7425	4	1	6
349	R:R:F320	5.055	6	1	6
350	R:R:L322	5.6925	4	1	4
351	R:R:I327	5.36333	6	1	6
352	R:R:F330	5.71375	8	1	8
353	R:R:R331	8.5375	4	1	4
354	R:R:F333	7.055	4	1	7
355	R:R:L334	6.90667	6	1	6
356	R:R:N345	3.7425	8	1	8
357	R:R:F347	4.62857	7	1	5
358	R:R:E350	6.6275	4	1	5
359	R:R:F351	5.865	8	1	6
360	R:R:W352	10.672	5	1	8
361	R:R:T355	4.308	5	1	4
362	R:R:F356	9.155	4	1	8
363	R:R:L360	7.11	5	1	4
364	R:R:E399	7.28	4	1	8
365	R:R:V404	3.29	4	1	4
366	R:R:Y408	6.20875	8	1	3
367	R:R:I409	5.54	4	1	5
368	R:R:Y411	8.6975	4	1	5
369	R:R:L414	6.106	5	1	6
370	R:R:I416	7.262	5	1	4
371	R:R:S417	4.826	5	1	6
372	R:R:Y418	5.95286	7	1	7
373	R:R:N419	3.8825	4	1	7
374	R:R:V420	4.9775	4	1	7
375	R:R:Y421	7.70286	7	1	8
376	R:R:Q432	4.655	4	47	7
377	R:R:Y435	4.768	5	47	3
378	R:R:F444	7.632	5	17	3
379	R:R:W458	10.658	5	17	4
380	R:R:Q459	7.862	5	17	7
381	R:R:L461	4.87	4	0	7
382	R:R:K462	7.46	4	35	4
383	R:R:H463	9.175	4	0	5
384	R:R:L464	3.395	4	0	7
385	R:R:R465	5.64	4	0	5
386	R:R:H466	5.37	4	35	4
387	R:R:N471	3.82667	6	1	6
388	R:R:M473	4.47	6	1	4
389	R:R:E475	3.85	4	1	5
390	R:R:D484	5.176	5	1	8
391	R:R:Y489	3.644	5	1	8
392	R:R:I491	4.915	4	1	8
393	R:R:W494	6.77714	7	1	7
394	R:R:S497	4.37667	6	30	3
395	R:R:I503	3.758	5	1	4
396	R:R:F505	5.645	4	1	4
397	R:R:Y511	5.27125	8	1	5
398	R:R:N512	7.552	5	1	4
399	R:R:V513	5.4	4	1	3
400	R:R:Y514	8.476	5	1	4
401	R:R:K517	5.722	5	1	1
402	R:R:L521	3.698	5	1	5
403	R:R:I523	5.2875	4	1	6
404	R:R:E525	4.95	4	1	4
405	R:R:W530	6.76778	9	1	8
406	R:R:V537	3.74	4	1	4
407	R:R:P538	6.965	4	1	8
408	R:R:F539	8.635	4	1	1
409	R:R:N541	13.815	4	1	5
410	R:R:D545	5.9625	4	1	5
411	R:R:C561	4.665	4	1	9
412	R:R:F563	7.6275	4	1	7
413	R:R:C568	3.846	5	1	9
414	R:R:P569	4.8525	4	1	5
415	R:R:Y573	4.9175	4	16	6
416	R:R:C582	3.7475	4	1	9
417	R:R:W590	4.82	4	16	6
418	R:R:S591	2.52	4	16	8
419	R:R:C598	4.065	4	16	9
420	R:R:F605	5.15	4	0	7
421	R:R:W608	4.336	5	21	5
422	R:R:T617	2.828	5	21	5
423	R:R:V630	4.6525	4	4	7
424	R:R:F634	4.714	5	4	9
425	R:R:I635	4.3175	4	4	4
426	R:R:N647	7.498	5	4	9
427	R:R:R648	4.5875	4	0	8
428	R:R:L650	4.16333	6	4	8
429	R:R:Y652	4.532	5	4	7
430	R:R:L654	4.9725	4	0	8
431	R:R:F662	4.19	5	0	8
432	R:R:F668	8.4725	4	0	9
433	R:R:I669	4.6525	4	21	8
434	R:R:R678	4.895	6	24	5
435	R:R:Q681	7.345	4	9	9
436	R:R:F684	8.72	7	9	8
437	R:R:F688	8.2025	4	0	8
438	R:R:C691	4.065	4	51	8
439	R:R:I695	4.0975	4	0	7
440	R:R:K698	4.322	5	4	9
441	R:R:R701	8.388	5	4	8
442	R:R:V705	3.735	4	4	9
443	R:R:F706	5.206	5	4	9
444	R:R:Q724	9.625	4	4	8
445	R:R:F725	3.295	4	0	5
446	R:R:V728	4.752	5	4	7
447	R:R:Q735	8.256	5	52	9
448	R:R:W742	6.832	5	0	9
449	R:R:P748	3.705	4	24	9
450	R:R:Y751	6.665	4	25	3
451	R:R:N753	7.3875	4	25	7
452	R:R:I761	3.775	4	25	7
453	R:R:F762	5.11	4	0	7
454	R:R:I763	4.7725	4	0	7
455	R:R:Y779	9.135	4	52	9
456	R:R:C787	4.0475	4	0	8
457	R:R:F788	5.8625	4	0	8
458	R:R:F790	5.088	5	53	7
459	R:R:L797	4.068	5	4	8
460	R:R:F801	4.27167	6	4	9
461	R:R:E803	4.558	5	4	9
462	R:R:F814	6.97333	6	9	9
463	R:R:F815	5.6525	4	9	7
464	R:R:W818	9.61833	6	9	9
465	R:R:F821	4.79143	7	23	9
466	R:R:I822	2.9075	4	9	7
467	R:R:P823	3.464	5	9	9
468	R:R:T828	2.17	4	0	8
469	R:R:E837	6.4925	4	9	9
470	R:R:V838	4.194	5	21	7
471	R:R:I841	6.4575	4	9	9
472	R:R:L842	3.715	4	21	9
473	R:R:L849	4.035	4	0	8
474	R:R:F853	6.25571	7	4	9
475	R:R:K856	6.11	5	4	9
476	R:R:I857	3.56	4	4	8
477	A:A:I26	3.9075	4	5	9
478	A:A:R42	5.4475	4	3	9
479	A:A:L45	4.9075	4	3	8
480	A:A:L46	3.84167	6	3	8
481	A:A:G47	2.945	4	3	9
482	A:A:N50	7.6375	4	0	9
483	A:A:S51	3.2675	4	0	9
484	A:A:I56	6.895	4	13	7
485	A:A:F212	5.1525	4	0	9
486	A:A:N218	9.99	4	3	4
487	A:A:F219	5.30167	6	18	8
488	A:A:H220	7.28	4	3	7
489	A:A:M221	5.255	4	0	8
490	A:A:F222	6.63	5	3	7
491	A:A:V224	6.722	5	3	9
492	A:A:R231	4.9525	4	0	9
493	A:A:R232	9.23	4	3	8
494	A:A:K233	4.898	5	3	9
495	A:A:W234	6.45429	7	3	9
496	A:A:F238	5.60714	7	3	9
497	A:A:I244	4.0525	4	3	8
498	A:A:F246	5.27667	6	3	9
499	A:A:V247	5.99	4	13	7
500	A:A:D249	7.625	4	0	8
501	A:A:L270	3.7175	4	3	6
502	A:A:F273	4.95	6	3	9
503	A:A:I276	3.2175	4	3	8
504	A:A:W277	9.2	6	3	6
505	A:A:W281	9.42833	6	3	5
506	A:A:L282	4.225	4	3	9
507	A:A:I288	5.88	6	13	9
508	A:A:F290	6.53143	7	13	9
509	A:A:L291	4.365	4	3	8
510	A:A:N292	5.468	5	13	9
511	A:A:K300	6.8975	4	54	9
512	A:A:L302	3.2125	4	33	2
513	A:A:Y318	13.665	4	3	6
514	A:A:D331	5.2775	4	33	4
515	A:A:V334	4.68	4	33	4
516	A:A:K338	8.205	4	3	5
517	A:A:Y339	7.272	5	3	3
518	A:A:F340	11.03	4	3	7
519	A:A:R342	5.1	4	3	4
520	A:A:F345	3.77833	6	3	8
521	A:A:I348	6.225	4	3	4
522	A:A:S349	5.035	4	3	7
523	A:A:Y360	8.49286	7	13	8
524	A:A:H362	7.285	4	13	9
525	A:A:F363	8.824	5	3	5
526	A:A:T364	6.535	4	13	9
527	A:A:C365	3.61	4	0	8
528	A:A:R374	7.7425	4	13	4
529	A:A:F376	4.63286	7	18	8
530	A:A:N387	5.7475	4	32	8
531	A:A:L388	6.03	5	4	8
532	A:A:R389	4.565	4	4	5
533	A:A:Y391	5.33	4	4	4
534	A:A:L393	3.105	4	4	8
535	A:A:V394	6.1775	4	4	8
536	B:B:L7	9.32	4	34	8
537	B:B:E10	3.9375	4	34	8
538	B:B:R22	5.855	4	3	6
539	B:B:L30	4.276	5	3	5
540	B:B:V40	4.205	4	26	3
541	B:B:I43	3.7425	4	0	3
542	B:B:M45	5.3975	4	0	4
543	B:B:H54	7.81667	6	5	9
544	B:B:K57	10.6075	4	3	9
545	B:B:I58	4.6775	4	5	9
546	B:B:Y59	8.33	4	3	8
547	B:B:W63	7.524	5	5	7
548	B:B:L69	6.5975	4	15	5
549	B:B:V71	5.0675	4	0	8
550	B:B:S72	5.505	4	5	9
551	B:B:Q75	7.8225	4	3	9
552	B:B:D76	6.646	5	5	9
553	B:B:I80	7.81	5	5	8
554	B:B:I81	4.48	4	15	7
555	B:B:W82	11.18	5	5	9
556	B:B:N88	5.575	4	0	7
557	B:B:K89	8.52	6	5	9
558	B:B:H91	5.2225	4	15	5
559	B:B:L95	4.874	5	15	8
560	B:B:W99	10.354	5	3	9
561	B:B:Y105	5.34714	7	15	6
562	B:B:N110	7.0375	4	3	4
563	B:B:Y111	8.17167	6	3	4
564	B:B:C114	4.215	4	15	8
565	B:B:G115	2.23	5	0	9
566	B:B:L117	3.18	5	3	9
567	B:B:I123	4.648	5	3	6
568	B:B:Y124	6.04833	6	15	6
569	B:B:N125	7.4975	4	3	4
570	B:B:V133	6.15	4	15	4
571	B:B:R134	3.115	4	3	3
572	B:B:L139	6.3025	4	0	9
573	B:B:H142	6.71333	6	3	9
574	B:B:G144	3.9425	4	3	8
575	B:B:Y145	4.96833	6	3	8
576	B:B:R150	4.844	5	6	6
577	B:B:F151	4.61	7	3	9
578	B:B:L152	5.59333	6	6	3
579	B:B:I157	4.3675	4	3	7
580	B:B:T159	3.99667	6	3	9
581	B:B:S160	4.815	4	6	6
582	B:B:S161	7.55	4	3	9
583	B:B:D163	8.975	6	3	9
584	B:B:C166	4.14	5	6	8
585	B:B:L168	3.1175	4	6	6
586	B:B:W169	7.7775	4	3	8
587	B:B:I171	3.7375	4	3	6
588	B:B:T178	3.9925	4	6	4
589	B:B:F180	5.70714	7	6	7
590	B:B:H183	5.71429	7	6	9
591	B:B:D186	8.0675	4	3	9
592	B:B:V187	4.748	5	6	9
593	B:B:L190	4.136	5	6	5
594	B:B:F199	6.20833	6	6	9
595	B:B:V200	6.2025	4	3	6
596	B:B:S201	3.6	4	6	9
597	B:B:C204	3.73	5	3	7
598	B:B:D205	5.19	4	6	9
599	B:B:K209	10.89	4	6	6
600	B:B:L210	5.144	5	3	5
601	B:B:W211	8.305	6	6	8
602	B:B:D212	9.56	4	3	9
603	B:B:R219	5.08	4	3	5
604	B:B:Q220	5.20143	7	3	7
605	B:B:F222	8.518	5	3	8
606	B:B:H225	8.54571	7	3	9
607	B:B:D228	6.892	5	3	9
608	B:B:I229	3.7425	4	3	7
609	B:B:I232	3.9425	4	3	8
610	B:B:F234	4.34571	7	3	5
611	B:B:F235	8.13571	7	3	6
612	B:B:P236	5.655	4	3	7
613	B:B:N237	6.908	5	3	5
614	B:B:F241	5.5175	8	3	6
615	B:B:T243	4.92	5	3	8
616	B:B:G244	2.81	4	55	5
617	B:B:S245	8.2925	4	3	9
618	B:B:D246	7.99	4	3	9
619	B:B:D247	8.68	5	3	9
620	B:B:T249	4.9475	4	3	6
621	B:B:R251	8.72	5	3	8
622	B:B:F253	6.87667	6	3	6
623	B:B:D254	5.1675	4	3	9
624	B:B:L255	3.9175	4	3	6
625	B:B:R256	8.098	5	3	9
626	B:B:D258	8.522	5	3	7
627	B:B:L261	4.1925	4	3	5
628	B:B:M262	4.4525	4	3	4
629	B:B:Y264	4.406	5	3	5
630	B:B:I269	4.735	4	19	4
631	B:B:S277	3.5525	4	14	5
632	B:B:F278	6.595	6	3	7
633	B:B:R283	5.78833	6	26	9
634	B:B:L284	5.415	4	0	5
635	B:B:L286	4.696	5	14	7
636	B:B:Y289	7.485	6	19	7
637	B:B:N295	7.292	5	19	6
638	B:B:V296	4.2075	4	0	5
639	B:B:W297	4.49	4	19	8
640	B:B:D298	6.0625	4	26	9
641	B:B:L300	7.275	4	0	6
642	B:B:K301	5.045	4	26	5
643	B:B:H311	8.09833	6	14	9
644	B:B:R314	11.7717	6	3	8
645	B:B:L318	4.434	5	14	6
646	B:B:T321	8.505	4	5	7
647	B:B:G324	2.295	4	0	9
648	B:B:M325	4.935	4	5	5
649	B:B:T329	5.325	4	14	8
650	B:B:W332	10.095	8	3	9
651	B:B:D333	8.0625	4	14	9
652	B:B:L336	4.4175	4	0	7
653	B:B:K337	9.385	4	14	6
654	B:B:I338	2.9325	4	5	5
655	B:B:W339	8.44	5	14	9
656	G:G:Q11	6.035	4	34	3
657	G:G:L15	3.924	5	34	2
658	G:G:E22	5.47667	6	3	9
659	G:G:Y40	9.3275	4	3	6
660	G:G:D48	6.4425	4	0	9
661	G:G:P49	3.435	4	5	7
662	G:G:L51	5.116	5	26	6
663	G:G:V54	3.8325	4	5	6
664	G:G:P60	6.36	4	5	9
665	G:G:F61	5.57571	7	5	8
666	H:H:?1	15.3967	6	2	0
667	H:H:?3	16.79	6	1	0
668	H:H:?8	16.0975	4	29	0
669	X:X:?4	8.70083	12	12	0
670	X:X:W1	5.75556	9	2	0
671	X:X:?2	8.61167	6	2	0
672	H:H:?11	12.205	6	1	0
673	H:H:?13	15.02	4	31	0
674	W:W:W1	4.67667	9	1	0
675	W:W:?3	4.2875	4	0	0
676	W:W:?2	12.5917	6	1	0
677	W:W:?4	9.65846	13	9	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	S:S:F98	S:S:P22	41.3326	8.67	Yes	No	2	4	5
2	S:S:F98	S:S:R25	82.4647	17.1	Yes	Yes	2	4	4
3	S:S:D23	S:S:Q24	10.318	2.61	No	No	0	1	5
4	S:S:F347	S:S:Q24	20.6391	10.54	Yes	No	0	5	5
5	S:S:F347	S:S:L71	82.655	2.44	Yes	Yes	0	5	4
6	S:S:G35	S:S:G36	21.6295	2.11	Yes	Yes	2	8	7
7	S:S:F114	S:S:R96	100	5.34	Yes	Yes	2	5	4
8	S:S:R25	S:S:R96	82.4741	2.13	Yes	Yes	2	4	4
9	S:S:F114	S:S:F98	100	6.43	Yes	Yes	2	5	4
10	S:S:H41	S:S:I40	100	5.3	Yes	Yes	2	7	5
11	S:S:I40	S:S:L71	100	2.85	Yes	Yes	2	5	4
12	S:S:E350	S:S:Y63	10.3174	7.86	Yes	Yes	2	5	5
13	S:S:A26	S:S:N345	20.6366	4.69	No	Yes	0	6	8
14	S:S:F68	S:S:N345	61.9218	4.83	Yes	Yes	2	7	8
15	S:S:N345	S:S:Q72	61.8977	6.6	Yes	Yes	2	8	7
16	S:S:F333	S:S:Q72	20.6874	9.37	Yes	Yes	2	7	7
17	S:S:F333	S:S:I75	41.3239	6.28	Yes	Yes	2	7	4
18	S:S:I75	S:S:I97	31.0063	2.94	Yes	Yes	2	4	8
19	S:S:K28	S:S:Y95	10.32	16.72	No	Yes	2	5	8
20	S:S:I97	S:S:Y95	41.2724	7.25	Yes	Yes	2	8	8
21	S:S:H344	S:S:Y95	20.64	3.27	No	Yes	2	3	8
22	S:S:G30	S:S:T92	31.0447	1.82	No	No	0	9	7
23	S:S:N82	S:S:T92	41.3725	5.85	No	No	0	9	7
24	S:S:L93	S:S:N82	51.7135	5.49	Yes	No	0	9	9
25	S:S:L34	S:S:L93	100	4.15	Yes	Yes	0	7	9
26	S:S:L34	S:S:M74	100	2.83	Yes	Yes	2	7	8
27	S:S:G30	S:S:G94	20.6964	2.11	No	No	0	9	9
28	S:S:D31	S:S:L91	20.6544	9.5	No	Yes	0	8	6
29	S:S:I32	S:S:L91	100	7.14	Yes	Yes	0	6	6
30	S:S:I139	S:S:V460	100	3.07	Yes	No	0	5	7
31	S:S:P163	S:S:V460	100	3.53	Yes	No	0	8	7
32	S:S:I162	S:S:P163	100	3.39	Yes	Yes	0	6	8
33	S:S:I162	S:S:L157	100	4.28	Yes	Yes	2	6	7
34	S:S:L157	S:S:V141	100	4.47	Yes	No	2	7	7
35	S:S:F114	S:S:V141	100	6.55	Yes	No	2	5	7
36	S:S:I139	S:S:L431	82.4647	4.28	Yes	No	11	5	8
37	S:S:I32	S:S:V455	61.9875	3.07	Yes	Yes	11	6	4
38	S:S:I78	S:S:M74	20.6355	2.92	Yes	Yes	2	6	8
39	S:S:L34	S:S:V424	10.3337	2.98	Yes	No	2	7	8
40	S:S:I78	S:S:V424	10.3185	3.07	Yes	No	2	6	8
41	S:S:G35	S:S:T138	20.6352	1.82	Yes	No	0	8	6
42	S:S:F114	S:S:L37	100	3.65	Yes	No	0	5	6
43	S:S:L37	S:S:T100	20.6225	4.42	No	No	0	6	7
44	S:S:L37	S:S:V153	100	2.98	No	Yes	0	6	6
45	S:S:F38	S:S:M74	100	6.22	Yes	Yes	2	7	8
46	S:S:F38	S:S:I97	82.5713	3.77	Yes	Yes	2	7	8
47	S:S:F38	S:S:W70	100	3.01	Yes	Yes	2	7	5
48	S:S:V142	S:S:Y167	31.2151	2.52	No	Yes	2	7	8
49	S:S:W70	S:S:Y167	20.6997	5.79	Yes	Yes	2	5	8
50	S:S:G67	S:S:W70	10.369	5.63	No	Yes	2	4	5
51	S:S:P39	S:S:W70	20.6241	5.4	Yes	Yes	2	6	5
52	S:S:P39	S:S:T145	20.6268	8.74	Yes	Yes	2	6	5
53	S:S:T145	S:S:Y167	20.7007	6.24	Yes	Yes	2	5	8
54	S:S:N102	S:S:P39	20.6251	4.89	No	Yes	0	3	6
55	S:S:D99	S:S:I40	51.5819	12.59	Yes	Yes	2	9	5
56	S:S:D99	S:S:F347	51.5816	4.78	Yes	Yes	0	9	5
57	S:S:C60	S:S:H41	100	7.37	Yes	Yes	2	7	7
58	S:S:C101	S:S:H41	82.508	5.9	Yes	Yes	2	8	7
59	S:S:C101	S:S:D99	82.5289	6.22	Yes	Yes	2	8	9
60	S:S:N64	S:S:R66	10.4986	6.03	No	Yes	0	4	5
61	S:S:C60	S:S:V44	100	3.42	Yes	No	0	7	2
62	S:S:V44	S:S:V58	61.8812	8.02	No	No	0	2	1
63	S:S:T103	S:S:V44	20.6271	4.76	No	No	0	4	2
64	S:S:C60	S:S:K106	61.881	3.23	Yes	Yes	2	7	4
65	S:S:K106	S:S:T103	61.8862	3	Yes	No	0	4	4
66	S:S:C101	S:S:K106	100	4.85	Yes	Yes	2	8	4
67	S:S:A45	S:S:V58	41.2541	1.7	No	No	0	1	1
68	S:S:A45	S:S:I61	20.6271	3.25	No	No	0	1	2
69	R:R:Y161	S:S:P55	29.118	16.69	No	Yes	0	4	6
70	R:R:L461	R:R:Y161	33.2775	2.34	Yes	No	0	7	4
71	R:R:L461	R:R:P163	93.5917	6.57	Yes	Yes	0	7	8
72	R:R:I162	R:R:P163	100	3.39	Yes	Yes	1	6	8
73	R:R:I162	R:R:N118	41.4004	4.25	Yes	Yes	1	6	4
74	R:R:N118	R:R:Q117	37.2691	2.64	Yes	Yes	1	4	6
75	R:R:I120	R:R:Q117	33.13	4.12	No	Yes	0	3	6
76	R:R:I120	R:R:L125	31.089	4.28	No	Yes	0	3	4
77	R:R:L461	R:R:R465	54.0759	6.07	Yes	Yes	0	7	5
78	R:R:R465	S:S:D50	27.0382	4.76	Yes	Yes	0	5	3
79	R:R:H466	R:R:R465	22.8785	3.39	Yes	Yes	0	4	5
80	R:R:W458	S:S:D50	18.7192	3.35	Yes	Yes	0	4	3
81	R:R:W458	S:S:P55	18.7191	12.16	Yes	Yes	17	4	6
82	R:R:Q459	R:R:W458	29.1185	15.33	Yes	Yes	17	7	4
83	R:R:H463	R:R:L443	12.4794	10.29	Yes	No	0	5	3
84	R:R:H466	R:R:L443	14.5593	5.14	Yes	No	0	4	3
85	R:R:Q459	S:S:K52	12.4793	4.07	Yes	Yes	17	7	3
86	S:S:Q245	S:S:R62	10.3808	2.34	Yes	No	0	4	4
87	S:S:P274	S:S:Q245	98.1911	4.74	Yes	Yes	0	3	4
88	S:S:F65	S:S:Y63	100	8.25	Yes	Yes	2	2	5
89	S:S:P407	S:S:R66	100	2.88	Yes	Yes	2	1	5
90	S:S:P407	S:S:T406	92.8128	3.5	Yes	No	2	1	4
91	S:S:F68	S:S:Y408	72.2002	11.35	Yes	Yes	2	7	3
92	S:S:Q72	S:S:Y408	92.8069	6.76	Yes	Yes	2	7	3
93	S:S:R66	S:S:R69	100	3.2	Yes	Yes	2	5	8
94	S:S:W70	X:X:?2	92.8244	9.17	Yes	Yes	2	5	0
95	S:S:W70	X:X:W1	100	2.81	Yes	Yes	2	5	0
96	S:S:T145	X:X:W1	51.6078	4.85	Yes	Yes	2	5	0
97	S:S:A168	S:S:Y167	20.6828	2.67	No	Yes	2	5	8
98	S:S:A168	X:X:W1	30.9933	3.89	No	Yes	2	5	0
99	S:S:A107	S:S:V153	62.5156	1.7	No	Yes	0	7	6
100	S:S:A107	S:S:V149	41.9048	1.7	No	No	0	7	4
101	S:S:G146	S:S:V149	21.2917	3.68	No	No	0	5	4
102	S:S:G146	X:X:W1	31.508	4.22	No	Yes	2	5	0
103	S:S:R69	S:S:Y411	82.5239	17.49	Yes	Yes	0	8	5
104	S:S:S417	S:S:W70	100	6.18	No	Yes	2	6	5
105	S:S:L414	S:S:S417	100	4.5	Yes	No	2	6	6
106	S:S:L334	S:S:Y411	10.3171	4.69	Yes	Yes	0	6	5
107	S:S:A73	S:S:V420	51.5814	3.39	No	Yes	0	7	7
108	S:S:A73	S:S:F330	41.2553	4.16	No	Yes	0	7	8
109	S:S:F330	S:S:F76	61.8713	5.36	Yes	Yes	2	8	7
110	S:S:E79	S:S:F333	30.9366	9.33	No	Yes	2	7	7
111	S:S:E80	S:S:F76	30.9551	8.16	No	Yes	2	8	7
112	S:S:F76	S:S:I327	30.9544	3.77	Yes	Yes	2	7	6
113	S:S:A77	S:S:Y421	10.319	4	No	Yes	0	8	8
114	S:S:E80	S:S:Y421	10.3102	6.73	No	Yes	2	8	8
115	S:S:I327	S:S:Y421	72.1851	9.67	Yes	Yes	2	6	8
116	S:S:Y421	S:S:Y425	41.3201	6.95	Yes	Yes	2	8	8
117	S:S:I81	S:S:L93	51.6117	2.85	Yes	Yes	0	9	9
118	S:S:I81	S:S:L87	30.9149	5.71	Yes	Yes	2	9	6
119	S:S:A428	S:S:I81	10.35	4.87	No	Yes	0	9	9
120	S:S:P85	X:X:?3	61.8884	3.02	No	No	0	3	0
121	S:S:P89	X:X:?3	82.5178	3.02	No	No	0	8	0
122	S:S:P89	S:S:Y435	100	6.95	No	No	0	8	3
123	S:S:I452	S:S:Y435	100	4.84	No	No	0	3	3
124	S:S:I452	S:S:L91	100	2.85	No	Yes	0	3	6
125	S:S:P85	S:S:S84	41.2589	3.56	No	No	0	3	6
126	S:S:H429	S:S:L87	61.8756	5.14	No	Yes	2	6	6
127	S:S:F469	S:S:H429	82.4962	19.23	Yes	No	2	8	6
128	S:S:F469	S:S:S426	100	2.64	Yes	Yes	2	8	7
129	S:S:L464	S:S:S426	100	3	Yes	Yes	0	7	7
130	S:S:L464	S:S:P163	100	3.28	Yes	Yes	0	7	8
131	S:S:L87	S:S:Q432	100	5.32	Yes	No	0	6	7
132	S:S:L88	S:S:L91	61.8581	5.54	No	Yes	0	9	6
133	S:S:A110	S:S:F98	41.2575	4.16	No	Yes	0	5	4
134	S:S:F98	S:S:S113	41.2575	6.61	Yes	No	0	4	4
135	R:R:F180	R:R:N155	15.4823	4.83	Yes	Yes	1	5	5
136	R:R:L157	R:R:Q164	100	5.32	Yes	Yes	1	7	8
137	R:R:I162	R:R:L157	100	4.28	Yes	Yes	1	6	7
138	R:R:F180	R:R:Q179	100	10.54	Yes	Yes	1	5	5
139	S:S:K106	S:S:S105	61.8862	3.06	Yes	No	0	4	4
140	S:S:T111	S:S:V153	21.3311	7.93	No	Yes	2	7	6
141	S:S:L157	S:S:T111	22.642	2.95	Yes	No	2	7	7
142	S:S:L156	S:S:T111	11.0107	5.9	No	No	0	5	7
143	R:R:L156	S:S:L112	13.0841	4.15	No	No	0	5	5
144	R:R:L112	R:R:L156	17.2122	2.77	Yes	No	0	5	5
145	S:S:N118	S:S:Q117	20.7524	2.64	No	No	0	4	6
146	S:S:F160	S:S:I162	82.5252	2.51	Yes	Yes	2	7	6
147	S:S:F160	S:S:V115	20.6323	10.49	Yes	No	0	7	5
148	R:R:E109	S:S:S122	10.3339	2.87	Yes	No	0	5	3
149	R:R:Y20	S:S:L125	10.4139	2.34	Yes	Yes	1	2	4
150	S:S:A140	S:S:P163	62.1073	1.87	No	Yes	0	6	8
151	S:S:G143	S:S:Q164	20.6309	4.93	No	Yes	0	9	8
152	S:S:Q164	S:S:V153	100	7.16	Yes	Yes	2	8	6
153	S:S:L157	S:S:Q164	100	7.99	Yes	Yes	2	7	8
154	S:S:G143	S:S:S166	20.6211	1.86	No	Yes	0	9	9
155	S:S:F183	S:S:Q164	100	10.54	Yes	Yes	2	8	8
156	S:S:F183	S:S:S166	20.6267	3.96	Yes	Yes	2	8	9
157	S:S:A144	S:S:V149	30.9266	3.39	No	No	0	6	4
158	S:S:S147	X:X:W1	100	6.18	No	Yes	2	8	0
159	S:S:F183	S:S:L174	100	13.4	Yes	Yes	2	8	7
160	S:S:L174	S:S:S171	100	4.5	Yes	No	0	7	7
161	S:S:S147	S:S:S171	100	6.52	No	No	0	8	7
162	S:S:L174	S:S:T151	100	5.9	Yes	Yes	2	7	5
163	S:S:F180	S:S:T151	100	5.19	Yes	Yes	2	5	5
164	S:S:A154	S:S:F180	100	2.77	No	Yes	2	7	5
165	S:S:A154	S:S:Q164	100	3.03	No	Yes	2	7	8
166	S:S:D217	S:S:T151	100	4.34	Yes	Yes	2	6	5
167	S:S:S150	S:S:S169	10.3132	6.52	Yes	Yes	2	8	8
168	S:S:F180	S:S:N155	30.936	6.04	Yes	Yes	2	5	5
169	S:S:F180	S:S:Q179	20.9258	9.37	Yes	Yes	2	5	5
170	R:R:V104	S:S:N155	10.3113	5.91	No	Yes	2	4	5
171	R:R:V104	S:S:Q179	15.4692	7.16	No	Yes	2	4	5
172	R:R:A152	S:S:N155	10.3158	3.13	No	Yes	2	5	5
173	S:S:G158	S:S:S182	20.6414	3.71	No	No	0	6	7
174	S:S:L461	S:S:S182	41.2829	3	Yes	No	0	7	7
175	S:S:L461	S:S:P163	100	6.57	Yes	Yes	0	7	8
176	S:S:F160	S:S:L159	41.2647	3.65	Yes	No	0	7	5
177	R:R:L108	S:S:L159	20.6323	4.15	No	No	0	4	5
178	S:S:K181	S:S:Y161	20.6416	7.17	No	No	0	7	4
179	S:S:L461	S:S:Y161	100	2.34	Yes	No	0	7	4
180	R:R:P55	S:S:Y161	100	9.74	Yes	No	0	6	4
181	R:R:L51	R:R:P55	100	3.28	Yes	Yes	11	6	6
182	R:R:L51	S:S:L461	100	4.15	Yes	Yes	11	6	7
183	S:S:A457	S:S:P163	20.6414	1.87	No	Yes	0	4	8
184	S:S:L184	S:S:L464	100	4.15	No	Yes	0	6	7
185	S:S:I427	S:S:V165	41.6084	3.07	Yes	Yes	0	5	6
186	S:S:T186	S:S:V165	31.6624	3.17	No	Yes	2	8	6
187	S:S:I416	S:S:N419	41.4156	2.83	Yes	No	0	4	7
188	S:S:N419	S:S:T186	93.486	2.92	No	No	0	7	8
189	S:S:F479	S:S:L184	61.8494	10.96	Yes	No	2	8	6
190	S:S:F479	S:S:S426	61.8498	3.96	Yes	Yes	2	8	7
191	S:S:I187	S:S:N419	83.3215	4.25	Yes	No	0	6	7
192	S:S:S170	X:X:W1	62.2005	4.94	Yes	Yes	2	7	0
193	S:S:D190	S:S:Y218	31.202	5.75	Yes	Yes	2	8	7
194	S:S:D217	S:S:L173	100	4.07	Yes	Yes	2	6	5
195	S:S:E191	S:S:R172	100	9.3	No	Yes	0	3	4
196	S:S:E191	S:S:N189	12.595	7.89	No	No	0	3	8
197	S:S:P221	S:S:R172	100	2.88	No	Yes	2	3	4
198	S:S:L173	S:S:P221	100	6.57	Yes	No	2	5	3
199	R:R:R220	S:S:R172	100	2.13	Yes	Yes	2	6	4
200	R:R:R220	S:S:L173	100	10.93	Yes	Yes	2	6	5
201	S:S:R185	S:S:S175	30.936	5.27	Yes	Yes	2	9	8
202	S:S:C482	S:S:S175	26.8196	6.89	No	Yes	2	7	8
203	S:S:C482	S:S:D484	20.624	3.11	No	Yes	2	7	8
204	S:S:D484	S:S:R185	41.2551	7.15	Yes	Yes	2	8	9
205	S:S:N176	S:S:Q179	10.6226	2.64	No	Yes	0	6	5
206	S:S:N176	S:S:N178	15.771	8.17	No	No	0	6	3
207	S:S:F183	S:S:K177	10.3178	3.72	Yes	No	0	8	7
208	R:R:Y246	S:S:N178	20.9222	18.61	No	No	0	3	3
209	S:S:D190	S:S:Q193	10.7895	13.05	Yes	Yes	2	8	9
210	S:S:Q193	S:S:S296	10.6783	4.33	Yes	No	0	9	8
211	S:S:S296	S:S:Y218	100	6.36	No	Yes	0	8	7
212	S:S:E191	S:S:K225	100	13.5	No	Yes	0	3	3
213	S:S:T195	S:S:Y511	100	2.5	Yes	Yes	2	4	5
214	S:S:K225	S:S:T195	100	3	Yes	Yes	2	3	4
215	S:S:Y489	S:S:Y511	15.8242	3.97	Yes	Yes	2	8	5
216	S:S:F320	S:S:Q193	17.2851	12.88	Yes	Yes	2	6	9
217	S:S:D199	S:S:T195	34.1055	4.34	Yes	Yes	2	7	4
218	S:S:E229	S:S:K225	100	10.8	Yes	Yes	2	5	3
219	S:S:F270	S:S:M197	99.001	9.95	Yes	No	2	7	7
220	S:S:F320	S:S:M197	82.5273	6.22	Yes	No	2	6	7
221	S:S:F270	S:S:V268	100	2.62	Yes	Yes	2	7	6
222	S:S:E229	S:S:R233	100	9.3	Yes	Yes	2	5	4
223	S:S:A213	S:S:I223	16.6267	4.87	No	Yes	0	4	5
224	S:S:G219	S:S:Y218	31.0609	2.9	No	Yes	0	7	7
225	S:S:F226	S:S:F270	100	4.29	Yes	Yes	2	6	7
226	S:S:D199	S:S:L521	31.0078	4.07	Yes	Yes	2	7	5
227	S:S:L521	S:S:Y511	31.0881	3.52	Yes	Yes	2	5	5
228	S:S:F204	S:S:I200	79.3162	2.51	Yes	Yes	0	7	8
229	S:S:F320	S:S:I200	50.5951	3.77	Yes	Yes	0	6	8
230	S:S:I200	S:S:L294	49.6617	2.85	Yes	Yes	0	8	7
231	S:S:L294	S:S:V268	100	5.96	Yes	Yes	0	7	6
232	S:S:F226	S:S:I201	100	2.51	Yes	Yes	2	6	6
233	S:S:I235	S:S:R233	100	2.51	Yes	Yes	2	7	4
234	S:S:F204	S:S:W206	33.0828	11.02	Yes	Yes	2	7	9
235	S:S:I201	S:S:W206	100	4.7	Yes	Yes	2	6	9
236	S:S:I235	S:S:V209	92.929	3.07	Yes	Yes	2	7	8
237	S:S:E202	S:S:I235	77.555	2.73	No	Yes	2	5	7
238	S:S:E202	S:S:R205	37.2244	5.82	No	No	2	5	4
239	H:H:?2	S:S:E202	37.2244	5.91	No	No	2	0	5
240	S:S:L521	S:S:Y203	18.6378	3.52	Yes	No	2	5	5
241	S:S:I523	S:S:L521	18.6378	8.56	No	Yes	2	6	5
242	S:S:E525	S:S:F204	68.4782	4.66	Yes	Yes	2	4	7
243	H:H:?1	S:S:R205	34.1182	6.5	Yes	No	2	0	4
244	H:H:?1	H:H:?2	34.1182	33.04	Yes	No	2	0	0
245	S:S:L294	S:S:V266	100	2.98	Yes	Yes	0	7	7
246	S:S:V537	S:S:W206	49.5171	2.45	Yes	Yes	2	4	9
247	S:S:E525	S:S:V537	16.513	4.28	Yes	Yes	2	4	4
248	S:S:S540	S:S:W206	66.0683	7.41	No	Yes	2	9	9
249	S:S:S540	S:S:V266	66.0565	6.46	No	Yes	2	9	7
250	H:H:?1	S:S:N207	31.008	11.02	Yes	No	2	0	6
251	S:S:C561	S:S:N207	24.8078	11.02	Yes	No	2	9	6
252	S:S:D238	S:S:W208	100	16.75	Yes	Yes	2	8	9
253	S:S:D238	S:S:F239	100	4.78	Yes	Yes	2	8	6
254	S:S:F239	S:S:I259	72.3108	2.51	Yes	No	0	6	6
255	S:S:I212	S:S:I259	20.7863	2.94	Yes	No	0	6	6
256	S:S:I212	S:S:V269	100	3.07	Yes	No	0	6	5
257	S:S:V269	S:S:W299	100	9.81	No	Yes	0	5	7
258	S:S:S296	S:S:W299	100	2.47	No	Yes	0	8	7
259	S:S:F239	S:S:I267	36.3915	3.77	Yes	Yes	2	6	7
260	S:S:I212	S:S:I267	10.4561	2.94	Yes	Yes	2	6	7
261	S:S:I267	S:S:W293	10.46	9.4	Yes	Yes	2	7	8
262	S:S:V269	S:S:W293	100	2.45	No	Yes	0	5	8
263	S:S:C236	S:S:W208	36.1231	2.61	Yes	Yes	2	9	9
264	S:S:T263	S:S:W208	36.1119	4.85	No	Yes	0	5	9
265	S:S:A264	S:S:D238	36.1117	3.09	No	Yes	2	7	8
266	S:S:C542	S:S:W208	36.1118	14.37	No	Yes	2	9	9
267	S:S:P559	S:S:W208	100	5.4	Yes	Yes	2	6	9
268	S:S:C562	S:S:W208	36.1119	5.22	No	Yes	2	9	9
269	S:S:G210	S:S:V209	100	1.84	No	Yes	0	8	8
270	S:S:I223	S:S:T211	33.0163	6.08	Yes	Yes	2	5	5
271	S:S:F226	S:S:I237	100	2.51	Yes	No	2	6	6
272	S:S:S240	S:S:T211	33.0051	7.99	No	Yes	0	4	5
273	S:S:I212	S:S:I243	20.6458	5.89	Yes	No	2	6	5
274	S:S:I212	S:S:L279	100	2.85	Yes	No	2	6	5
275	S:S:A214	S:S:D216	20.6306	3.09	Yes	No	0	5	6
276	S:S:D216	S:S:Y218	30.9423	3.45	No	Yes	0	6	7
277	S:S:A214	S:S:G219	20.6439	1.95	Yes	No	0	5	7
278	S:S:A214	S:S:S271	25.7835	3.42	Yes	No	0	5	4
279	S:S:A214	S:S:D275	10.3733	3.09	Yes	Yes	0	5	5
280	S:S:D217	S:S:R220	100	3.57	Yes	Yes	2	6	6
281	R:R:R172	S:S:R220	100	2.13	Yes	Yes	2	4	6
282	S:S:A298	X:X:W1	10.311	6.48	No	Yes	2	6	0
283	R:R:L173	S:S:R220	100	8.5	Yes	Yes	2	5	6
284	S:S:G222	S:S:P221	100	2.03	No	No	0	7	3
285	R:R:I223	R:R:T211	15.6136	6.08	No	Yes	0	5	5
286	R:R:F270	R:R:G222	100	4.52	Yes	No	0	7	7
287	R:R:G222	R:R:P221	100	2.03	No	Yes	0	7	3
288	R:R:P221	R:R:R172	100	2.88	Yes	Yes	2	3	4
289	R:R:L173	R:R:P221	100	8.21	Yes	Yes	2	5	3
290	R:R:I237	R:R:R227	14.5523	2.51	Yes	Yes	0	6	4
291	R:R:I237	R:R:T211	10.3717	9.12	Yes	Yes	1	6	5
292	R:R:F226	R:R:M197	100	2.49	Yes	Yes	1	6	7
293	R:R:F270	R:R:M197	100	7.46	Yes	Yes	1	7	7
294	R:R:A198	R:R:F226	100	2.77	No	Yes	1	7	6
295	R:R:A198	R:R:E229	100	3.02	No	Yes	1	7	5
296	R:R:E229	R:R:K225	100	13.5	Yes	Yes	0	5	3
297	R:R:E191	R:R:K225	100	14.85	No	Yes	0	3	3
298	R:R:E191	R:R:R172	100	8.14	No	Yes	0	3	4
299	S:S:A230	S:S:F226	16.5337	4.16	No	Yes	0	6	6
300	S:S:F239	S:S:S262	36.1117	6.61	Yes	No	2	6	7
301	S:S:F239	S:S:V258	100	5.24	Yes	No	2	6	4
302	S:S:I243	S:S:V255	10.3315	3.07	No	No	0	5	5
303	S:S:I259	S:S:V255	46.4142	3.07	No	No	0	6	5
304	S:S:H254	S:S:V258	100	4.15	No	No	2	3	4
305	S:S:Q245	S:S:Y246	100	14.65	Yes	No	0	4	3
306	R:R:N178	S:S:Y246	100	15.12	No	No	0	3	3
307	S:S:E251	S:S:S247	41.2774	10.06	No	No	0	4	2
308	S:S:I252	S:S:S247	51.5967	6.19	No	No	0	4	2
309	S:S:E282	S:S:I252	72.2353	5.47	Yes	No	0	6	4
310	S:S:E282	S:S:V256	100	2.85	Yes	No	0	6	5
311	S:S:I283	S:S:V256	100	6.14	Yes	No	0	4	5
312	S:S:I283	S:S:L279	100	4.28	Yes	No	0	4	5
313	S:S:D248	S:S:E251	30.958	9.09	No	No	0	3	4
314	S:S:D248	S:S:E250	20.6387	9.09	No	No	0	3	2
315	S:S:E249	S:S:E250	10.3194	7.61	No	No	0	2	2
316	S:S:I252	S:S:P278	10.3194	3.39	No	No	0	4	2
317	S:S:R286	S:S:V256	30.9522	6.54	Yes	No	0	4	5
318	S:S:Q260	S:S:R286	30.9367	5.84	No	Yes	0	5	4
319	S:S:I288	S:S:Q260	51.5698	2.74	No	No	0	4	5
320	S:S:I288	S:S:K291	61.8948	2.91	No	No	0	4	6
321	S:S:K291	S:S:W293	72.1932	3.48	No	Yes	2	6	8
322	S:S:E282	S:S:Q253	10.3224	8.92	Yes	No	0	6	3
323	S:S:Q253	S:S:R286	20.6244	5.84	No	Yes	38	3	4
324	H:H:?5	S:S:H254	100	2.29	No	No	0	0	3
325	H:H:?5	S:S:N261	36.087	24.5	No	No	0	0	4
326	S:S:N261	S:S:Q260	10.3193	2.64	No	No	0	4	5
327	H:H:?1	S:S:F539	12.3989	7.6	Yes	Yes	2	0	1
328	S:S:K265	S:S:S540	99.094	3.06	No	No	0	5	9
329	S:S:I292	S:S:V266	99.0831	3.07	Yes	Yes	2	7	7
330	S:S:L276	S:S:W299	10.3229	10.25	No	Yes	8	5	7
331	S:S:G273	S:S:P274	10.3641	4.06	No	Yes	8	4	3
332	S:S:I305	S:S:W299	30.9967	5.87	Yes	Yes	8	4	7
333	S:S:E277	S:S:L304	67.2327	7.95	Yes	No	8	2	2
334	S:S:E277	S:S:Y310	56.8822	2.24	Yes	Yes	8	2	3
335	S:S:I280	S:S:I305	20.6672	4.42	No	Yes	0	5	4
336	S:S:V314	S:S:W293	10.3229	8.58	No	Yes	0	7	8
337	S:S:I280	S:S:V314	10.3369	6.14	No	No	0	5	7
338	S:S:E282	S:S:R285	10.3148	8.14	Yes	No	0	6	3
339	S:S:R285	S:S:R286	20.6264	4.26	No	Yes	0	3	4
340	S:S:V284	S:S:Y310	36.2359	10.09	No	Yes	8	3	3
341	S:S:H312	S:S:V284	25.8194	2.77	No	No	8	3	3
342	S:S:H312	S:S:N287	20.6617	5.1	No	No	0	3	6
343	S:S:N287	S:S:T289	10.3308	4.39	No	No	0	6	5
344	S:S:P538	S:S:W530	33.0177	18.92	No	Yes	2	8	8
345	S:S:W299	S:S:W494	100	3.75	Yes	Yes	8	7	7
346	S:S:T317	S:S:W494	10.3321	12.13	No	Yes	0	7	7
347	S:S:I318	S:S:L294	100	4.28	No	Yes	0	6	7
348	S:S:A295	S:S:W299	30.9416	11.67	No	Yes	0	7	7
349	S:S:A295	S:S:G319	20.6267	1.95	No	No	0	7	8
350	S:S:A300	S:S:G319	10.316	1.95	No	No	0	6	8
351	S:S:A321	S:S:S301	20.6369	1.71	Yes	No	0	5	5
352	S:S:A321	S:S:R415	82.5551	6.91	Yes	No	0	5	5
353	S:S:R415	X:X:?2	100	6.99	No	Yes	0	5	0
354	S:S:P407	S:S:S303	10.3151	3.56	Yes	No	0	1	3
355	S:S:A306	S:S:W494	10.3148	6.48	No	Yes	8	4	7
356	S:S:F505	S:S:I492	10.3683	7.54	No	No	0	4	5
357	S:S:A321	S:S:I492	20.6797	3.25	Yes	No	0	5	5
358	S:S:I503	S:S:W494	51.7419	4.7	No	Yes	8	4	7
359	S:S:M307	S:S:Y310	10.3296	4.79	No	Yes	8	3	3
360	S:S:F311	S:S:I503	41.4499	7.54	Yes	No	0	3	4
361	S:S:F311	S:S:G315	10.4094	7.53	Yes	No	0	3	4
362	S:S:F311	S:S:L496	10.3175	20.7	Yes	No	0	3	3
363	S:S:F311	S:S:G532	10.4094	3.01	Yes	No	0	3	1
364	S:S:G316	S:S:N493	33.1712	5.09	No	No	0	8	9
365	S:S:I528	S:S:N493	100	4.25	Yes	No	0	7	9
366	S:S:I528	S:S:W530	100	5.87	Yes	Yes	2	7	8
367	S:S:A324	S:S:H413	20.6264	5.85	No	No	0	5	7
368	S:S:H413	S:S:R415	61.8791	13.54	No	No	0	7	5
369	S:S:G325	S:S:Y418	10.3213	10.14	No	Yes	0	4	7
370	S:S:I327	S:S:Y418	100	3.63	Yes	Yes	2	6	7
371	S:S:M473	S:S:Y418	30.9695	3.59	Yes	Yes	2	4	7
372	S:S:M473	S:S:Q326	10.3213	4.08	Yes	No	0	4	3
373	S:S:I327	S:S:P328	30.9735	3.39	Yes	No	0	6	4
374	S:S:G329	S:S:P328	10.3246	2.03	No	No	0	5	4
375	S:S:N472	S:S:P328	10.3246	3.26	No	No	0	4	4
376	S:S:E332	S:S:R331	10.3185	2.33	No	Yes	0	5	4
377	S:S:R331	S:S:Y411	61.8899	13.38	Yes	Yes	0	4	5
378	S:S:I409	S:S:Y408	61.8912	6.04	Yes	Yes	2	5	3
379	S:S:I409	S:S:K335	41.2687	14.54	Yes	No	2	5	4
380	S:S:K335	S:S:S402	61.8941	3.06	No	No	0	4	4
381	S:S:K336	S:S:K341	20.6376	2.87	No	No	0	4	3
382	S:S:H338	S:S:K341	41.2752	11.79	Yes	No	0	4	3
383	S:S:H338	S:S:W352	100	3.17	Yes	Yes	2	4	8
384	S:S:F351	S:S:W352	100	3.01	Yes	Yes	2	6	8
385	S:S:V337	S:S:Y408	10.3207	6.31	No	Yes	2	5	3
386	S:S:P339	S:S:W352	100	28.38	No	Yes	2	7	8
387	S:S:H338	S:S:R340	41.275	10.16	Yes	No	0	4	4
388	S:S:L360	S:S:P339	100	3.28	No	No	0	4	7
389	S:S:G397	S:S:R340	20.6374	4.5	No	No	0	5	4
390	S:S:G397	S:S:T396	30.9499	3.64	No	No	0	5	6
391	S:S:E399	S:S:T396	92.8498	8.47	No	No	0	8	6
392	S:S:E399	S:S:W352	82.5494	5.45	No	Yes	2	8	8
393	S:S:N345	S:S:S342	20.6366	2.98	Yes	No	2	8	3
394	S:S:A348	S:S:N345	41.2732	4.69	No	Yes	2	5	8
395	S:S:H344	S:S:V343	10.32	6.92	No	No	0	3	3
396	S:S:A348	S:S:K349	20.6366	3.21	No	No	0	5	3
397	S:S:F351	S:S:I401	20.6427	6.28	Yes	Yes	2	6	7
398	S:S:F356	S:S:T355	51.5662	10.38	Yes	Yes	2	8	4
399	S:S:E353	S:S:L360	20.6376	2.65	No	No	0	7	4
400	S:S:T355	S:S:V404	10.3187	4.76	Yes	No	2	4	4
401	S:S:C358	S:S:C395	100	7.28	No	No	0	9	9
402	S:S:C395	S:S:L360	100	7.94	No	No	0	9	4
403	S:S:C358	S:S:P393	100	3.77	No	No	0	9	1
404	S:S:H359	S:S:R392	41.2751	10.16	No	No	0	4	1
405	S:S:P393	S:S:R392	82.5502	1.44	No	No	0	1	1
406	S:S:H359	S:S:Q361	20.6376	13.6	No	No	0	4	1
407	S:S:F391	S:S:R392	20.6376	9.62	No	No	0	1	1
408	S:S:D398	S:S:T396	30.95	11.56	No	No	0	3	6
409	S:S:N400	S:S:S402	41.2628	4.47	No	No	0	4	4
410	S:S:H413	S:S:T412	20.6264	5.48	No	No	0	7	5
411	S:S:L422	S:S:Y418	10.3692	7.03	No	Yes	0	8	7
412	S:S:F469	S:S:V477	20.6857	9.18	Yes	No	0	8	6
413	S:S:N471	S:S:Y418	92.8908	5.81	Yes	Yes	2	6	7
414	S:S:L467	S:S:S426	20.6233	3	No	Yes	2	7	7
415	S:S:A430	S:S:L464	20.6352	3.15	No	Yes	0	8	7
416	S:S:Q432	S:S:T436	82.5056	5.67	No	No	0	7	4
417	S:S:D433	S:S:H463	41.2414	2.52	No	Yes	0	4	5
418	S:S:I434	S:S:V455	41.2744	3.07	No	Yes	0	6	4
419	S:S:H463	S:S:L443	41.2407	6.43	Yes	No	0	5	3
420	S:S:K462	S:S:L443	61.8581	14.1	Yes	No	11	4	3
421	R:R:L51	S:S:K462	100	8.46	Yes	Yes	11	6	4
422	S:S:F444	S:S:H463	41.233	4.53	Yes	Yes	0	3	5
423	S:S:F444	S:S:K462	100	2.48	Yes	Yes	11	3	4
424	S:S:Q459	S:S:V455	41.3211	4.3	Yes	Yes	11	7	4
425	S:S:A450	S:S:F444	20.6165	4.16	No	Yes	11	3	3
426	S:S:H466	S:S:K462	20.6448	3.93	No	Yes	11	4	4
427	S:S:F444	S:S:S448	20.6329	2.64	Yes	No	0	3	3
428	R:R:P55	S:S:W458	100	13.51	Yes	Yes	11	6	4
429	S:S:N446	S:S:T445	20.6449	5.85	No	No	0	3	1
430	R:R:K52	S:S:T445	41.2898	7.51	No	No	0	3	1
431	R:R:D50	R:R:K52	82.5795	20.74	No	No	0	3	3
432	R:R:D50	S:S:K462	100	4.15	No	Yes	0	3	4
433	S:S:D451	S:S:K453	20.6259	6.91	No	No	0	3	2
434	S:S:I452	S:S:K453	61.8776	4.36	No	No	0	3	2
435	S:S:K453	S:S:K454	20.6259	2.87	No	No	0	2	3
436	S:S:E456	S:S:W458	41.2327	7.63	No	Yes	11	5	4
437	R:R:R54	S:S:E456	41.2367	5.82	No	No	11	2	5
438	R:R:P55	R:R:R54	82.4831	2.88	Yes	No	11	6	2
439	S:S:L461	S:S:R465	20.6412	2.43	Yes	No	11	7	5
440	S:S:N468	S:S:Q476	20.6425	6.6	No	No	28	6	3
441	S:S:Q476	S:S:T470	51.6063	5.67	No	No	0	3	5
442	S:S:G474	S:S:T470	61.9275	1.82	No	No	0	5	5
443	S:S:G474	S:S:N471	72.2487	3.39	No	Yes	0	5	6
444	S:S:N468	S:S:T478	10.3213	5.85	No	No	28	6	3
445	H:H:?7	S:S:Q476	20.6425	5.94	No	No	28	0	3
446	H:H:?7	S:S:T478	10.3213	3.94	No	No	28	0	3
447	S:S:E475	S:S:N471	10.3212	10.52	No	Yes	2	5	6
448	S:S:E475	S:S:M473	10.3212	5.41	No	Yes	2	5	4
449	S:S:F479	S:S:L485	41.2482	7.31	Yes	No	0	8	4
450	S:S:D480	S:S:D484	10.3188	3.99	No	Yes	0	7	8
451	S:S:V513	S:S:Y514	21.7429	7.57	Yes	Yes	2	3	4
452	S:S:N488	S:S:V513	21.7429	4.43	No	Yes	2	4	3
453	S:S:N488	S:S:N512	18.6368	5.45	No	Yes	2	4	4
454	S:S:N512	S:S:Y514	18.6368	5.81	Yes	Yes	2	4	4
455	S:S:I491	S:S:V508	66.0758	3.07	No	No	0	8	7
456	S:S:I528	S:S:V508	99.1137	9.22	Yes	No	0	7	7
457	S:S:G509	S:S:I491	33.0379	5.29	No	No	0	9	8
458	S:S:H495	S:S:N493	100	10.2	No	No	0	7	9
459	S:S:H495	S:S:K506	100	14.41	No	No	0	7	5
460	S:S:H495	S:S:L529	33.0457	12.86	No	No	0	7	4
461	S:S:P498	S:S:S497	66.0914	3.56	No	Yes	0	3	3
462	S:S:S497	S:S:V504	100	3.23	Yes	No	0	3	3
463	S:S:K506	S:S:V504	100	1.52	No	No	0	5	3
464	S:S:D500	S:S:S497	33.0457	4.42	No	Yes	0	4	3
465	S:S:G501	S:S:S497	33.0457	1.86	No	Yes	0	5	3
466	S:S:S497	S:S:S502	33.0457	3.26	Yes	No	0	3	4
467	S:S:E499	S:S:P498	33.0457	11	No	No	0	4	3
468	S:S:K506	S:S:K527	100	5.75	No	Yes	0	5	3
469	S:S:E507	S:S:K527	33.0457	2.7	No	Yes	0	5	3
470	S:S:N512	S:S:Y510	12.4246	2.33	Yes	No	0	4	3
471	S:S:A515	S:S:N512	18.6369	4.69	No	Yes	0	4	4
472	S:S:A515	S:S:E519	12.4246	4.53	No	No	0	4	4
473	S:S:E526	S:S:K527	66.0914	2.7	No	Yes	40	3	3
474	S:S:K527	S:S:N524	33.0457	9.79	Yes	No	40	3	5
475	S:S:E526	S:S:R535	33.0457	2.33	No	No	0	3	4
476	S:S:F533	S:S:S531	49.587	5.28	No	No	0	1	4
477	S:S:I292	S:S:S531	66.1159	1.55	Yes	No	0	7	4
478	S:S:F533	S:S:S534	33.058	2.64	No	No	0	1	4
479	S:S:E536	S:S:S534	16.529	5.75	No	No	0	5	4
480	S:S:F539	S:S:R544	39.2203	2.14	Yes	No	0	1	5
481	S:S:C568	S:S:H595	12.0754	2.95	Yes	Yes	0	9	5
482	R:R:P569	S:S:P569	100	7.79	Yes	Yes	1	5	5
483	R:R:C568	R:R:P569	100	1.88	Yes	Yes	1	9	5
484	R:R:C568	R:R:G549	100	1.96	Yes	No	1	9	9
485	R:R:G549	R:R:T550	100	1.82	No	No	1	9	6
486	R:R:C546	R:R:T550	100	5.07	No	No	1	9	6
487	R:R:C546	R:R:F563	100	2.79	No	Yes	1	9	7
488	R:R:D578	R:R:F563	100	3.58	No	Yes	1	7	7
489	R:R:D545	R:R:D578	100	14.64	Yes	No	1	5	7
490	R:R:D545	R:R:N541	100	2.69	Yes	Yes	1	5	5
491	R:R:F539	R:R:N541	100	8.46	Yes	Yes	1	1	5
492	R:R:F539	R:R:K265	100	2.48	Yes	No	0	1	5
493	R:R:I292	R:R:K265	100	2.91	Yes	No	0	7	5
494	R:R:I292	R:R:V266	100	6.14	Yes	Yes	1	7	7
495	R:R:V209	R:R:V266	100	3.21	Yes	Yes	1	8	7
496	R:R:I235	R:R:V209	100	3.07	Yes	Yes	1	7	8
497	R:R:I235	R:R:R233	100	3.76	Yes	Yes	1	7	4
498	R:R:E229	R:R:R233	100	3.49	Yes	Yes	1	5	4
499	H:H:?3	R:R:D545	100	3.63	Yes	Yes	1	0	5
500	H:H:?3	R:R:F539	100	5.43	Yes	Yes	1	0	1
501	R:R:K265	R:R:S540	100	3.06	No	No	0	5	9
502	R:R:S540	R:R:V266	100	3.23	No	Yes	1	9	7
503	R:R:S540	R:R:W206	100	11.12	No	Yes	1	9	9
504	R:R:I201	R:R:W206	100	2.35	Yes	Yes	1	6	9
505	R:R:I201	R:R:I235	100	5.89	Yes	Yes	1	6	7
506	R:R:F226	R:R:I201	100	2.51	Yes	Yes	1	6	6
507	R:R:L294	R:R:V266	100	2.98	Yes	Yes	0	7	7
508	R:R:L294	R:R:V268	100	4.47	Yes	Yes	0	7	6
509	R:R:M197	R:R:V268	100	4.56	Yes	Yes	1	7	6
510	H:H:?1	S:S:D545	12.4237	6.05	Yes	No	0	0	5
511	S:S:E558	S:S:P559	100	6.29	No	Yes	0	5	6
512	S:S:E558	S:S:I555	100	5.47	No	No	0	5	5
513	S:S:E564	S:S:I555	72.2241	8.2	No	No	0	6	5
514	S:S:E556	S:S:G557	36.112	3.27	No	No	0	6	6
515	I:I:?2	S:S:G557	72.2241	3.14	No	No	41	0	6
516	I:I:?2	S:S:E558	100	2.43	No	No	0	0	5
517	I:I:?2	R:R:D234	36.112	7.48	No	No	41	0	5
518	S:S:E572	S:S:P569	100	7.86	No	Yes	0	7	5
519	S:S:E572	S:S:K584	100	5.4	No	No	0	7	4
520	S:S:K584	S:S:W590	100	3.48	No	Yes	10	4	6
521	S:S:H595	S:S:S591	16.2053	5.58	Yes	Yes	0	5	8
522	S:S:K601	S:S:W590	14.8357	2.32	No	Yes	10	8	6
523	S:S:I761	S:S:K601	14.7979	8.72	Yes	No	10	7	8
524	S:S:E759	S:S:W590	100	13.08	No	Yes	10	4	6
525	S:S:E757	S:S:I760	100	5.47	No	Yes	0	4	5
526	S:S:E757	S:S:E759	100	6.34	No	No	0	4	4
527	S:S:F605	S:S:I603	19.5062	2.51	Yes	Yes	0	7	4
528	S:S:I603	S:S:I761	19.5363	5.89	Yes	Yes	10	4	7
529	S:S:E604	S:S:I760	100	2.73	No	Yes	42	6	5
530	S:S:F762	S:S:I760	41.8517	6.28	Yes	Yes	42	7	5
531	S:S:E604	S:S:K831	100	9.45	No	No	0	6	9
532	S:S:F605	S:S:S607	19.0385	9.25	Yes	No	0	7	7
533	S:S:E610	S:S:S607	19.9211	5.75	Yes	No	0	7	7
534	S:S:E610	S:S:K831	12.237	2.7	Yes	No	0	7	9
535	S:S:E610	S:S:L606	14.1876	3.98	Yes	Yes	0	7	9
536	S:S:F832	S:S:L606	12.9853	2.44	Yes	Yes	0	5	9
537	S:S:F832	S:S:K831	100	12.41	Yes	No	0	5	9
538	S:S:F612	S:S:F832	100	11.79	Yes	Yes	9	8	5
539	S:S:F612	S:S:L616	92.5173	2.44	Yes	No	0	8	8
540	R:R:P823	S:S:F832	100	2.89	Yes	Yes	9	9	5
541	R:R:I822	S:S:F612	100	2.51	Yes	Yes	9	7	8
542	R:R:I822	R:R:P823	100	3.39	Yes	Yes	9	7	9
543	S:S:F668	S:S:V838	88.4557	3.93	Yes	No	0	9	7
544	S:S:L616	S:S:V838	88.5711	7.45	No	No	0	8	7
545	S:S:F684	X:X:?4	31.4249	19.98	Yes	Yes	12	8	0
546	S:S:Y825	X:X:?4	39.267	10.49	Yes	Yes	12	9	0
547	S:S:V833	S:S:Y825	42.2383	5.05	No	Yes	0	6	9
548	S:S:G830	S:S:V833	41.957	1.84	No	No	0	8	6
549	S:S:F762	S:S:G830	42.0942	4.52	Yes	No	0	7	8
550	S:S:F688	S:S:L848	73.3657	3.65	Yes	Yes	0	8	7
551	S:S:F684	S:S:F688	83.226	10.72	Yes	Yes	0	8	8
552	S:S:F853	S:S:L654	21.4286	6.09	Yes	Yes	7	9	8
553	S:S:C691	S:S:L654	27.7729	4.76	Yes	Yes	7	8	8
554	S:S:C691	S:S:L848	28.5542	6.35	Yes	Yes	7	8	7
555	S:S:I695	S:S:L654	27.7626	5.71	No	Yes	0	7	8
556	S:S:I695	S:S:L848	42.8329	4.28	No	Yes	0	7	7
557	S:S:F853	S:S:L655	11.905	8.53	Yes	No	7	9	9
558	S:S:L631	S:S:L655	11.1122	13.84	No	No	7	4	9
559	S:S:E803	S:S:I807	12.6965	2.73	Yes	Yes	7	9	9
560	S:S:I695	S:S:I807	14.6801	2.94	No	Yes	0	7	9
561	S:S:K698	S:S:T646	11.1136	3	Yes	No	0	9	9
562	S:S:K698	S:S:L654	19.8342	2.82	Yes	Yes	7	9	8
563	S:S:C694	S:S:L654	13.4949	7.94	Yes	Yes	0	6	8
564	S:S:L650	S:S:Q724	12.0866	2.66	Yes	Yes	7	8	8
565	S:S:F668	S:S:I841	70.568	3.77	Yes	Yes	0	9	9
566	R:R:F814	W:W:?4	100	3.63	Yes	Yes	9	9	0
567	R:R:I822	W:W:?4	100	4.26	Yes	Yes	9	7	0
568	R:R:L849	R:R:T627	100	5.9	Yes	No	0	8	7
569	R:R:F662	R:R:T627	100	2.59	Yes	No	0	8	7
570	R:R:F662	R:R:S845	100	7.93	Yes	No	0	8	8
571	R:R:C661	R:R:S845	100	5.16	No	No	0	7	8
572	R:R:C661	R:R:F684	100	5.59	No	Yes	0	7	8
573	R:R:F684	W:W:?4	100	19.07	Yes	Yes	9	8	0
574	R:R:I695	R:R:L654	100	4.28	Yes	Yes	0	7	8
575	R:R:C787	R:R:I695	100	3.27	Yes	Yes	0	8	7
576	R:R:C787	R:R:I692	100	3.27	Yes	No	0	8	7
577	R:R:F688	R:R:I692	100	8.79	Yes	No	0	8	7
578	R:R:F684	R:R:F688	100	7.5	Yes	Yes	0	8	8
579	R:R:F688	R:R:T780	100	2.59	Yes	No	0	8	7
580	R:R:T780	W:W:?4	100	6.59	No	Yes	0	7	0
581	R:R:F688	R:R:F814	100	13.93	Yes	Yes	0	8	9
582	R:R:R96	R:R:Y20	31.0218	6.17	Yes	Yes	1	4	2
583	R:R:I135	R:R:Y20	10.3691	10.88	No	Yes	0	4	2
584	R:R:E109	R:R:P22	15.4889	3.14	Yes	No	1	5	5
585	R:R:F98	R:R:P22	25.8168	8.67	Yes	No	1	4	5
586	R:R:F114	R:R:F98	46.4919	6.43	Yes	Yes	1	5	4
587	R:R:F347	R:R:L71	98.5864	2.44	Yes	Yes	1	5	4
588	R:R:F38	R:R:L71	100	3.65	Yes	Yes	1	7	4
589	R:R:F38	R:R:G36	100	3.01	Yes	Yes	1	7	7
590	R:R:G35	R:R:G36	100	2.11	Yes	Yes	1	8	7
591	R:R:F347	R:R:Q24	10.3565	12.88	Yes	No	0	5	5
592	R:R:L71	R:R:N345	26.1897	4.12	Yes	Yes	1	4	8
593	R:R:K28	R:R:Y95	10.3408	14.33	No	Yes	1	5	8
594	R:R:I97	R:R:Y95	20.6728	8.46	Yes	Yes	1	8	8
595	R:R:N82	R:R:T92	10.597	4.39	No	No	0	9	7
596	R:R:L93	R:R:N82	12.7276	5.49	Yes	No	0	9	9
597	R:R:I33	R:R:R96	10.3536	3.76	No	Yes	0	5	4
598	R:R:T111	R:R:V153	18.7283	7.93	No	Yes	1	7	6
599	R:R:L156	R:R:T111	34.4109	5.9	No	No	0	5	7
600	R:R:F38	R:R:W70	100	2	Yes	Yes	1	7	5
601	R:R:V142	R:R:Y167	22.7143	2.52	No	Yes	1	7	8
602	R:R:F42	R:R:N64	15.5857	20.54	Yes	Yes	1	3	4
603	R:R:P274	R:R:Q245	10.4212	4.74	Yes	Yes	0	3	4
604	R:R:Q245	R:R:Y246	26.0754	11.27	Yes	No	0	4	3
605	R:R:P39	R:R:W70	10.3463	5.4	Yes	Yes	1	6	5
606	R:R:N102	R:R:P39	10.3303	4.89	No	Yes	0	3	6
607	R:R:T145	R:R:Y167	10.3247	7.49	Yes	Yes	1	5	8
608	R:R:G146	R:R:T145	15.4824	3.64	No	Yes	0	5	5
609	R:R:G146	R:R:V149	10.3249	1.84	No	No	0	5	4
610	R:R:H41	R:R:I40	20.7048	6.63	Yes	Yes	1	7	5
611	R:R:F347	R:R:I40	15.5493	3.77	Yes	Yes	1	5	5
612	R:R:D99	R:R:H41	10.3425	5.04	Yes	Yes	1	9	7
613	R:R:D99	R:R:F347	62.1164	4.78	Yes	Yes	1	9	5
614	R:R:F68	R:R:Y63	25.9423	6.19	Yes	Yes	1	7	5
615	R:R:C60	R:R:H41	31.0397	13.27	No	Yes	1	7	7
616	R:R:C101	R:R:D99	46.6156	6.22	Yes	Yes	1	8	9
617	R:R:L304	R:R:P274	10.3621	3.28	Yes	Yes	1	2	3
618	R:R:K106	R:R:V58	10.3892	3.04	Yes	No	0	4	1
619	R:R:C101	R:R:K106	36.313	3.23	Yes	Yes	1	8	4
620	R:R:K106	R:R:T103	15.5838	3	Yes	No	0	4	4
621	R:R:K52	R:R:S53	20.6449	3.06	No	No	0	3	3
622	R:R:F65	R:R:Y63	25.8983	8.25	Yes	Yes	1	2	5
623	R:R:F65	R:R:Y408	51.7888	2.06	Yes	Yes	1	2	3
624	R:R:F68	R:R:Y408	46.5988	8.25	Yes	Yes	1	7	3
625	R:R:R69	R:R:Y408	100	2.06	Yes	Yes	1	8	3
626	R:R:R66	R:R:R69	100	5.33	Yes	Yes	1	5	8
627	R:R:S417	R:R:W70	62.1355	3.71	Yes	Yes	1	6	5
628	R:R:W70	W:W:?2	31.015	14.41	Yes	Yes	1	5	0
629	R:R:E354	R:R:Y63	15.5122	14.59	No	Yes	1	4	5
630	R:R:F351	R:R:T355	25.9119	2.59	Yes	Yes	1	6	4
631	R:R:F65	R:R:P407	15.6601	7.22	Yes	No	0	2	1
632	R:R:S147	R:R:Y218	100	5.09	No	Yes	0	8	7
633	R:R:Y218	W:W:W1	100	1.93	Yes	Yes	1	7	0
634	R:R:D275	R:R:Q245	46.5697	2.61	Yes	Yes	0	5	4
635	R:R:S272	W:W:W1	31.0287	3.71	No	Yes	0	5	0
636	R:R:W70	W:W:W1	100	4.69	Yes	Yes	1	5	0
637	R:R:F330	R:R:S417	36.2434	2.64	Yes	Yes	1	8	6
638	R:R:F330	R:R:F333	10.3673	2.14	Yes	Yes	1	8	7
639	R:R:L334	R:R:R69	20.6737	4.86	Yes	Yes	1	6	8
640	R:R:R69	R:R:Y411	20.6837	11.32	Yes	Yes	1	8	5
641	R:R:L414	R:R:S417	20.7003	6.01	Yes	Yes	1	6	6
642	R:R:I416	R:R:Y167	14.479	4.84	Yes	Yes	1	4	8
643	R:R:I416	R:R:N419	18.7228	2.83	Yes	Yes	1	4	7
644	R:R:I187	R:R:R185	100	2.51	Yes	Yes	1	6	9
645	R:R:F183	R:R:R185	100	6.41	Yes	Yes	1	8	9
646	R:R:F183	R:R:Q164	100	10.54	Yes	Yes	1	8	8
647	R:R:M74	R:R:V424	10.3709	3.04	Yes	No	0	8	8
648	R:R:I81	R:R:Y425	29.3152	4.84	No	No	0	9	8
649	R:R:I81	R:R:L93	25.2257	5.71	No	Yes	0	9	9
650	R:R:F330	R:R:I327	31.2059	6.28	Yes	Yes	1	8	6
651	R:R:I327	R:R:L414	31.1033	4.28	Yes	Yes	1	6	6
652	R:R:N471	R:R:V477	100	4.43	Yes	No	0	6	6
653	R:R:F469	R:R:V477	100	13.11	No	No	0	8	6
654	R:R:F469	R:R:L467	33.0648	3.65	No	No	0	8	7
655	R:R:L467	R:R:S426	24.8288	3	No	No	0	7	7
656	R:R:Y421	R:R:Y425	31.2379	17.87	Yes	No	1	8	8
657	R:R:P85	W:W:?3	24.808	3.02	No	Yes	0	3	0
658	R:R:P85	R:R:S84	16.5387	3.56	No	No	0	3	6
659	R:R:F469	R:R:H429	100	21.5	No	No	0	8	6
660	R:R:L87	R:R:Q432	65.9676	2.66	No	Yes	0	6	7
661	R:R:L87	W:W:?3	41.2359	2.54	No	Yes	0	6	0
662	R:R:Q432	R:R:Y435	49.6156	3.38	Yes	Yes	47	7	3
663	R:R:F183	R:R:S166	10.3882	3.96	Yes	Yes	1	8	9
664	R:R:A168	R:R:Y167	10.3244	2.67	No	Yes	1	5	8
665	R:R:G148	R:R:S147	100	1.86	No	No	0	4	8
666	R:R:G148	R:R:T151	100	1.82	No	Yes	0	4	5
667	R:R:D217	R:R:L173	100	5.43	No	Yes	0	6	5
668	R:R:D217	R:R:R220	100	3.57	No	Yes	0	6	6
669	R:R:F180	R:R:T151	100	6.49	Yes	Yes	1	5	5
670	R:R:C482	R:R:D484	12.3916	4.67	No	Yes	1	7	8
671	R:R:N176	R:R:Q179	100	6.6	No	Yes	0	6	5
672	R:R:E191	R:R:N189	20.7202	7.89	No	No	0	3	8
673	R:R:N419	R:R:T186	100	2.92	Yes	No	0	7	8
674	R:R:L422	R:R:T186	100	4.42	No	No	0	8	8
675	R:R:L422	R:R:N471	49.5837	4.12	No	Yes	1	8	6
676	R:R:I187	R:R:L322	100	5.71	Yes	Yes	1	6	4
677	R:R:L322	R:R:Y489	100	2.34	Yes	Yes	1	4	8
678	R:R:V513	R:R:Y511	100	2.52	Yes	Yes	1	3	5
679	R:R:V486	R:R:V513	12.3684	3.21	No	Yes	1	3	3
680	R:R:F320	R:R:Q193	100	7.03	Yes	Yes	1	6	9
681	R:R:F320	R:R:Y489	100	4.13	Yes	Yes	1	6	8
682	R:R:K517	R:R:R233	12.3832	3.71	Yes	Yes	1	1	4
683	R:R:D199	R:R:L521	12.3958	4.07	Yes	Yes	1	7	5
684	R:R:L521	R:R:Y511	100	2.34	Yes	Yes	1	5	5
685	R:R:F204	R:R:I200	100	2.51	Yes	Yes	1	7	8
686	R:R:F320	R:R:I200	100	2.51	Yes	Yes	1	6	8
687	R:R:L521	R:R:Y203	100	3.52	Yes	No	1	5	5
688	R:R:I523	R:R:L521	100	5.71	Yes	Yes	1	6	5
689	R:R:F204	R:R:W530	100	12.03	Yes	Yes	1	7	8
690	R:R:I318	R:R:W530	37.157	2.35	Yes	Yes	1	6	8
691	R:R:N207	R:R:N541	100	12.26	No	Yes	1	6	5
692	H:H:?3	R:R:N207	100	15.92	Yes	No	1	0	6
693	R:R:C561	R:R:N207	100	7.87	Yes	No	1	9	6
694	R:R:C236	R:R:C561	100	7.28	Yes	Yes	1	9	9
695	R:R:C236	R:R:W208	95.8743	2.61	Yes	Yes	1	9	9
696	R:R:D238	R:R:W208	100	20.1	Yes	Yes	1	8	9
697	R:R:D238	R:R:F239	100	3.58	Yes	Yes	1	8	6
698	R:R:F239	R:R:I212	37.1576	3.77	Yes	No	1	6	6
699	R:R:I212	R:R:I243	35.1167	4.42	No	Yes	1	6	5
700	R:R:I243	R:R:S271	27.004	3.1	Yes	No	0	5	4
701	R:R:A214	R:R:S271	22.9169	3.42	No	No	0	5	4
702	R:R:A214	R:R:D275	20.7725	4.63	No	Yes	1	5	5
703	R:R:C542	R:R:C561	100	1.82	No	Yes	1	9	9
704	R:R:C542	R:R:W208	95.8455	20.89	No	Yes	1	9	9
705	R:R:A213	R:R:I223	10.3135	4.87	No	No	0	4	5
706	R:R:D216	R:R:D275	30.9307	2.66	No	Yes	1	6	5
707	R:R:F239	R:R:V258	14.4549	2.62	Yes	No	0	6	4
708	R:R:E241	R:R:V258	12.3691	4.28	No	No	0	5	4
709	R:R:I267	R:R:W293	100	7.05	Yes	Yes	1	7	8
710	R:R:W293	R:R:W299	25.888	2.81	Yes	Yes	1	8	7
711	R:R:E241	R:R:H254	10.4321	8.62	No	No	0	5	3
712	R:R:E251	R:R:S247	12.4328	2.87	No	No	0	4	2
713	R:R:S244	R:R:S247	15.5409	1.63	No	No	0	4	2
714	R:R:D215	R:R:S244	18.6491	1.47	Yes	No	0	6	4
715	R:R:I283	R:R:V256	10.529	4.61	No	No	0	4	5
716	R:R:I283	R:R:V313	21.0149	4.61	No	Yes	0	4	3
717	R:R:V313	R:R:W293	72.6998	2.45	Yes	Yes	1	3	8
718	R:R:G273	R:R:P274	10.3162	4.06	No	Yes	0	4	3
719	R:R:G273	R:R:S302	10.3206	3.71	No	No	0	4	5
720	R:R:E277	R:R:K281	16.5493	5.4	Yes	No	0	2	2
721	R:R:K281	R:R:Y310	20.6683	4.78	No	Yes	0	2	3
722	R:R:V314	R:R:Y310	16.5341	2.52	Yes	Yes	1	7	3
723	R:R:V284	R:R:Y310	16.4953	10.09	No	Yes	1	3	3
724	R:R:H312	R:R:V313	10.4408	5.54	No	Yes	1	3	3
725	R:R:F311	R:R:I503	10.6219	5.02	Yes	Yes	1	3	4
726	R:R:F311	R:R:G315	14.4586	6.02	Yes	No	1	3	4
727	R:R:F311	R:R:L496	16.7141	24.36	Yes	No	0	3	3
728	R:R:F311	R:R:G532	14.4586	4.52	Yes	No	1	3	1
729	R:R:G316	R:R:N493	31.9671	5.09	No	No	0	8	9
730	R:R:I318	R:R:N493	36.1681	2.83	Yes	No	0	6	9
731	R:R:A321	R:R:R415	17.5486	6.91	No	No	0	5	5
732	R:R:R415	W:W:?2	87.743	2.79	No	Yes	0	5	0
733	R:R:E475	R:R:N471	100	5.26	Yes	Yes	1	5	6
734	H:H:?11	R:R:E475	100	4.73	Yes	Yes	1	0	5
735	R:R:A324	R:R:H413	17.5486	4.39	No	No	0	5	7
736	R:R:H413	R:R:R415	52.6458	12.41	No	No	0	7	5
737	R:R:I327	R:R:P328	45.4488	3.39	Yes	No	0	6	4
738	R:R:G329	R:R:P328	22.7244	2.03	No	No	0	5	4
739	R:R:R331	R:R:Y411	15.5254	8.23	Yes	Yes	1	4	5
740	R:R:I409	R:R:K335	10.3817	4.36	Yes	No	1	5	4
741	R:R:I409	R:R:L334	10.3817	2.85	Yes	Yes	1	5	6
742	R:R:I409	R:R:Y408	10.3842	2.42	Yes	Yes	1	5	3
743	R:R:H338	R:R:P339	15.541	9.15	No	No	0	4	7
744	R:R:P339	R:R:W352	20.721	25.67	No	Yes	1	7	8
745	R:R:F351	R:R:W352	93.2436	3.01	Yes	Yes	1	6	8
746	R:R:L360	R:R:W352	41.4422	2.28	Yes	Yes	1	4	8
747	R:R:E399	R:R:T396	10.3606	12.7	Yes	No	1	8	6
748	R:R:E399	R:R:W352	20.721	4.36	Yes	Yes	1	8	8
749	R:R:N345	R:R:S342	10.3609	2.98	Yes	No	0	8	3
750	R:R:E353	R:R:L360	20.7213	7.95	No	Yes	1	7	4
751	R:R:F351	R:R:I401	15.5408	3.77	Yes	No	1	6	7
752	R:R:T355	R:R:V404	15.5407	4.76	Yes	Yes	1	4	4
753	R:R:C395	R:R:L360	10.3607	7.94	No	Yes	0	9	4
754	R:R:E353	R:R:H359	15.541	1.23	No	No	0	7	4
755	R:R:H359	R:R:Q361	10.3607	4.95	No	No	0	4	1
756	R:R:I401	R:R:S402	10.3607	1.55	No	No	0	7	4
757	R:R:H413	R:R:T412	17.5486	9.58	No	No	0	7	5
758	R:R:F479	R:R:S426	16.5233	6.61	No	No	0	8	7
759	R:R:I452	R:R:Y435	33.0773	8.46	No	Yes	0	3	3
760	R:R:I452	R:R:K453	24.808	1.45	No	No	0	3	2
761	R:R:G474	R:R:N471	16.5199	1.7	No	Yes	0	5	6
762	R:R:N512	R:R:Y514	43.3615	8.14	Yes	Yes	1	4	4
763	R:R:G501	R:R:S497	12.5356	1.86	No	Yes	0	5	3
764	R:R:G501	R:R:L496	14.6249	1.71	No	No	0	5	3
765	H:H:?11	R:R:Y510	31.0432	8.37	Yes	No	1	0	3
766	R:R:F522	R:R:Y510	49.6105	17.54	No	No	0	1	3
767	R:R:F522	R:R:N524	37.2079	2.42	No	No	0	1	5
768	R:R:E526	R:R:N524	12.4026	10.52	No	No	0	3	5
769	R:R:K527	R:R:N524	12.4026	5.6	No	No	0	3	5
770	R:R:C568	R:R:H595	17.3598	2.95	Yes	No	0	9	5
771	R:R:H595	R:R:S591	16.7083	2.79	No	Yes	0	5	8
772	R:R:S591	R:R:W590	15.8285	3.71	Yes	Yes	16	8	6
773	R:R:E759	R:R:W590	15.8221	4.36	No	Yes	16	4	6
774	R:R:E755	R:R:Q754	14.9917	14.02	No	No	25	4	4
775	R:R:E755	R:R:N753	14.2554	7.89	No	Yes	25	4	7
776	R:R:F762	R:R:N753	15.454	2.42	Yes	Yes	0	7	7
777	R:R:E757	R:R:F762	15.4403	5.83	No	Yes	0	4	7
778	R:R:E757	R:R:E759	15.8652	6.34	No	No	0	4	4
779	R:R:I761	R:R:Q754	14.8111	5.49	Yes	No	25	7	4
780	R:R:I763	R:R:R752	14.7853	5.01	Yes	No	0	7	3
781	R:R:I761	R:R:R752	14.8263	3.76	Yes	No	0	7	3
782	R:R:F668	R:R:I841	10.7373	3.77	Yes	Yes	0	9	9
783	R:R:F853	R:R:V630	13.8336	3.93	Yes	Yes	4	9	7
784	R:R:F853	R:R:L654	100	6.09	Yes	Yes	0	9	8
785	R:R:F853	R:R:I852	100	10.05	Yes	No	4	9	9
786	R:R:I695	R:R:I852	100	4.42	Yes	No	0	7	9
787	R:R:F853	R:R:L849	100	2.44	Yes	Yes	0	9	8
788	R:R:F634	R:R:F853	100	5.36	Yes	Yes	4	9	9
789	R:R:F634	R:R:Y652	100	5.16	Yes	Yes	4	9	7
790	R:R:F634	R:R:V643	15.8822	3.93	Yes	No	0	9	9
791	R:R:R638	R:R:Y652	100	4.12	No	Yes	4	6	7
792	R:R:R638	R:R:R648	100	6.4	No	Yes	0	6	8
793	R:R:E649	R:R:R648	100	4.65	No	Yes	0	7	8
794	R:R:E649	R:R:F725	100	4.66	No	Yes	0	7	5
795	R:R:F725	R:R:L653	100	4.87	Yes	No	0	5	5
796	R:R:C694	R:R:L653	100	4.76	No	No	4	6	5
797	R:R:C694	R:R:L654	100	6.35	No	Yes	0	6	8
798	R:R:K644	R:R:R648	100	2.48	No	Yes	0	8	8
799	A:A:V394	R:R:K644	100	4.55	Yes	No	0	8	8
800	A:A:L388	A:A:V394	100	8.94	Yes	Yes	4	8	8
801	A:A:L388	R:R:V705	100	2.98	Yes	Yes	4	8	9
802	A:A:L393	R:R:V705	100	2.98	Yes	Yes	4	8	9
803	A:A:L393	R:R:N647	100	4.12	Yes	Yes	4	8	9
804	R:R:K698	R:R:N647	100	2.8	Yes	Yes	4	9	9
805	R:R:K698	R:R:K856	100	2.87	Yes	Yes	4	9	9
806	R:R:I852	R:R:K856	100	2.91	No	Yes	4	9	9
807	R:R:E803	R:R:K698	100	2.7	Yes	Yes	4	9	9
808	R:R:E803	R:R:I807	100	2.73	Yes	No	0	9	9
809	R:R:I695	R:R:I807	100	4.42	Yes	No	0	7	9
810	R:R:F801	R:R:V702	20.2792	6.55	Yes	No	0	9	9
811	A:A:L393	R:R:V702	21.954	2.98	Yes	No	0	8	9
812	R:R:N647	R:R:R701	100	14.46	Yes	Yes	4	9	8
813	A:A:Y391	R:R:R701	100	7.2	Yes	Yes	4	4	8
814	A:A:L393	A:A:Y391	100	2.34	Yes	Yes	4	8	4
815	R:R:K793	R:R:L703	13.6097	2.82	No	No	0	7	7
816	R:R:L703	R:R:L797	17.0121	2.77	No	Yes	0	7	8
817	R:R:F706	R:R:L797	15.2323	4.87	Yes	Yes	4	9	8
818	R:R:F706	R:R:V705	22.0596	3.93	Yes	Yes	4	9	9
819	R:R:F801	R:R:L797	15.3892	2.44	Yes	Yes	4	9	8
820	A:A:E390	A:A:N387	100	9.2	No	Yes	0	4	8
821	A:A:E390	A:A:Y391	100	6.73	No	Yes	0	4	4
822	A:A:I383	A:A:N387	100	4.25	No	Yes	32	8	8
823	R:R:K793	R:R:R795	10.2073	2.48	No	No	0	7	9
824	A:A:I26	A:A:R22	100	3.76	Yes	No	0	9	4
825	A:A:R22	B:B:H91	100	4.51	No	Yes	0	4	5
826	B:B:H91	B:B:V133	100	5.54	Yes	Yes	15	5	4
827	B:B:V133	B:B:Y124	100	3.79	Yes	Yes	15	4	6
828	B:B:C114	B:B:Y124	100	5.38	Yes	Yes	15	8	6
829	B:B:C114	B:B:G115	100	1.96	Yes	Yes	0	8	9
830	B:B:G115	B:B:G116	100	2.11	Yes	No	0	9	9
831	B:B:G116	B:B:M101	100	3.49	No	No	0	9	9
832	A:A:C237	B:B:M101	100	4.86	No	No	0	8	9
833	A:A:C237	B:B:Y59	100	6.72	No	Yes	0	8	8
834	B:B:W332	B:B:Y59	100	12.54	Yes	Yes	3	9	8
835	A:A:W281	B:B:W332	100	3.75	Yes	Yes	3	5	9
836	A:A:R280	A:A:W281	100	13.99	No	Yes	0	5	5
837	A:A:R280	A:A:R283	100	4.26	No	No	0	5	3
838	A:A:R283	A:A:T284	100	6.47	No	No	0	3	4
839	A:A:R356	A:A:T284	100	2.59	No	No	0	2	4
840	A:A:R356	A:A:R389	100	2.13	No	Yes	0	2	5
841	A:A:Q385	A:A:R389	100	2.34	No	Yes	4	5	5
842	A:A:L388	A:A:Q385	100	7.99	Yes	No	4	8	5
843	A:A:R389	A:A:V394	100	2.62	Yes	Yes	4	5	8
844	A:A:S23	B:B:K89	24.7922	7.65	No	Yes	0	7	9
845	A:A:I26	B:B:K89	100	5.82	Yes	Yes	5	9	9
846	A:A:S23	B:B:N88	18.5899	8.94	No	Yes	0	7	7
847	B:B:D76	B:B:L55	43.3924	2.71	Yes	No	0	9	6
848	B:B:D76	B:B:K78	100	8.3	Yes	No	0	9	8
849	B:B:K78	B:B:P94	100	3.35	No	No	0	8	5
850	B:B:I93	B:B:P94	100	3.39	No	No	0	7	5
851	B:B:I93	B:B:Y124	100	6.04	No	Yes	15	7	6
852	B:B:D76	B:B:H54	100	8.82	Yes	Yes	5	9	9
853	A:A:E35	A:A:G34	18.6059	1.64	No	No	0	4	5
854	A:A:G34	B:B:L55	31.0098	3.42	No	No	0	5	6
855	A:A:E32	A:A:K36	24.8183	4.05	No	No	0	3	1
856	A:A:D33	A:A:K36	37.2274	5.53	No	No	0	5	1
857	A:A:D33	B:B:K78	43.432	5.53	No	No	0	5	8
858	A:A:N218	A:A:Q213	34.1851	9.24	Yes	No	0	4	3
859	A:A:Q213	A:A:R61	37.5446	4.67	No	No	0	3	8
860	A:A:F212	A:A:R61	54.356	3.21	Yes	No	0	9	8
861	A:A:F212	A:A:F219	100	9.65	Yes	Yes	0	9	8
862	A:A:F219	A:A:L41	100	7.31	Yes	No	0	8	6
863	A:A:I383	A:A:L41	100	2.85	No	No	0	8	6
864	A:A:L41	A:A:T242	100	5.9	No	No	0	6	8
865	A:A:F222	A:A:H220	17.3828	2.26	Yes	Yes	3	7	7
866	A:A:H220	A:A:N218	24.0949	3.83	Yes	Yes	3	7	4
867	A:A:I285	A:A:L282	12.3891	5.71	No	Yes	0	7	9
868	A:A:L282	A:A:N279	43.5426	5.49	Yes	No	3	9	8
869	A:A:N279	A:A:W281	100	3.39	No	Yes	3	8	5
870	B:B:Q75	B:B:W99	12.4198	13.14	Yes	Yes	3	9	9
871	B:B:K57	B:B:Q75	18.5867	12.2	Yes	Yes	3	9	9
872	B:B:K57	B:B:W332	24.7593	15.08	Yes	Yes	3	9	9
873	B:B:Q75	B:B:Y59	18.5752	4.51	Yes	Yes	3	9	8
874	A:A:F219	A:A:L43	100	2.44	Yes	No	0	8	7
875	A:A:L43	A:A:T242	100	2.95	No	No	0	7	8
876	A:A:I245	A:A:L43	100	7.14	No	No	0	7	7
877	A:A:L44	A:A:L46	10.7246	2.77	No	Yes	3	9	8
878	A:A:G47	A:A:L46	62.1707	3.42	Yes	Yes	3	9	8
879	A:A:G47	A:A:K53	100	3.49	Yes	No	3	9	9
880	A:A:K53	A:A:L45	100	4.23	No	Yes	3	9	8
881	A:A:L45	A:A:M221	100	8.48	Yes	Yes	0	8	8
882	A:A:F212	A:A:M221	100	4.98	Yes	Yes	0	9	8
883	A:A:I245	A:A:L45	100	2.85	No	Yes	0	7	8
884	A:A:I235	A:A:W234	100	3.52	No	Yes	3	9	9
885	A:A:I235	A:A:N279	100	4.25	No	No	3	9	8
886	A:A:I244	A:A:L46	20.3145	2.85	Yes	Yes	3	8	8
887	A:A:I244	A:A:I276	12.4261	2.94	Yes	Yes	3	8	8
888	A:A:I276	A:A:L282	24.993	2.85	Yes	Yes	3	8	9
889	A:A:D223	A:A:L45	20.2588	4.07	No	Yes	3	9	8
890	A:A:L46	A:A:R231	22.897	4.86	Yes	Yes	0	8	9
891	A:A:R231	A:A:W234	16.4938	9	Yes	Yes	0	9	9
892	A:A:F246	A:A:G47	100	3.01	Yes	Yes	3	9	9
893	A:A:G47	A:A:S51	100	1.86	Yes	Yes	0	9	9
894	A:A:S51	A:A:V247	100	4.85	Yes	Yes	0	9	7
895	A:A:F290	A:A:V247	100	3.93	Yes	Yes	13	9	7
896	A:A:F290	A:A:I288	100	6.28	Yes	Yes	13	9	9
897	A:A:I245	A:A:I288	100	4.42	No	Yes	0	7	9
898	A:A:A48	A:A:S51	67.5705	3.42	No	Yes	0	8	9
899	A:A:A48	A:A:N50	50.6777	3.13	No	Yes	0	8	9
900	A:A:D249	A:A:N50	50.6789	13.46	Yes	Yes	0	8	9
901	A:A:D249	A:A:S51	100	2.94	Yes	Yes	0	8	9
902	A:A:D49	A:A:N50	33.7854	6.73	No	Yes	0	8	9
903	A:A:N50	A:A:R265	33.7854	7.23	Yes	No	0	9	9
904	A:A:G52	A:A:N292	40.5405	1.7	No	Yes	0	9	9
905	A:A:I56	A:A:N292	27.0122	8.5	Yes	Yes	13	7	9
906	A:A:F290	A:A:I56	33.7649	3.77	Yes	Yes	13	9	7
907	A:A:N292	A:A:V247	27.0654	4.43	Yes	Yes	13	9	7
908	A:A:N292	A:A:T364	27.0344	2.92	Yes	Yes	13	9	9
909	A:A:F290	A:A:T364	40.5392	14.27	Yes	Yes	13	9	9
910	A:A:G52	A:A:T55	20.2702	1.82	No	No	0	9	9
911	A:A:K58	A:A:Q59	10.1683	8.14	No	No	0	9	9
912	A:A:Q59	A:A:R61	13.5641	11.68	No	No	0	9	8
913	A:A:V224	A:A:W234	18.6022	15.94	Yes	Yes	3	9	9
914	A:A:F219	A:A:F376	20.5071	4.29	Yes	Yes	18	8	8
915	A:A:G225	A:A:V224	12.4076	1.84	No	Yes	0	9	9
916	B:B:D163	B:B:S161	43.379	8.83	Yes	Yes	3	9	9
917	B:B:G162	B:B:S161	100	3.71	No	Yes	3	9	9
918	B:B:G162	B:B:Y145	100	7.24	No	Yes	3	9	8
919	A:A:W234	B:B:Y145	100	3.86	Yes	Yes	3	9	8
920	B:B:G144	B:B:S161	18.5967	3.71	Yes	Yes	3	8	9
921	B:B:D186	B:B:Y145	100	9.2	Yes	Yes	3	9	8
922	A:A:K233	B:B:Y145	100	3.58	Yes	Yes	3	9	8
923	B:B:C204	B:B:D186	100	4.67	Yes	Yes	3	7	9
924	A:A:D272	A:A:F246	11.6491	8.36	No	Yes	0	8	9
925	A:A:K233	B:B:D228	100	4.15	Yes	Yes	3	9	9
926	A:A:K233	B:B:N230	100	4.2	Yes	No	0	9	9
927	A:A:W281	B:B:R314	18.5874	9	Yes	Yes	3	5	8
928	A:A:I244	A:A:V287	16.71	6.14	Yes	No	3	8	6
929	A:A:F273	A:A:V287	10.2718	5.24	Yes	No	3	9	6
930	A:A:F246	A:A:F273	100	6.43	Yes	Yes	3	9	9
931	A:A:F246	A:A:V248	100	6.55	Yes	No	0	9	7
932	A:A:F246	A:A:L289	100	2.44	Yes	No	0	9	9
933	A:A:A269	A:A:V248	10.1486	3.39	No	No	0	9	7
934	A:A:F345	A:A:V248	100	2.62	Yes	No	0	8	7
935	A:A:F273	A:A:F345	100	5.36	Yes	Yes	3	9	8
936	A:A:F345	A:A:L289	100	6.09	Yes	No	0	8	9
937	A:A:D249	A:A:S251	100	4.42	Yes	No	0	8	9
938	A:A:K293	A:A:N292	20.261	9.79	No	Yes	0	9	9
939	A:A:L296	A:A:L297	100	2.77	No	No	0	6	8
940	A:A:L296	A:A:S251	100	4.5	No	No	0	6	9
941	A:A:L297	A:A:S250	33.7625	7.51	No	No	0	8	6
942	A:A:I341	A:A:S250	60.8924	3.1	No	No	0	8	6
943	A:A:I341	A:A:L291	91.3374	2.85	No	Yes	3	8	8
944	A:A:F345	A:A:L291	100	2.44	Yes	Yes	3	8	8
945	A:A:D252	A:A:S251	100	5.89	No	No	0	8	9
946	A:A:D252	A:A:N264	100	2.69	No	No	0	8	4
947	A:A:D252	A:A:K300	100	2.77	No	Yes	0	8	9
948	A:A:K300	A:A:Y253	100	13.14	Yes	No	0	9	4
949	A:A:I308	A:A:Y253	100	22.97	No	No	0	7	4
950	A:A:N264	A:A:Y311	100	11.63	No	No	0	4	6
951	A:A:E268	A:A:Q267	16.8928	3.82	No	No	0	9	4
952	A:A:F312	A:A:Q267	33.7857	17.57	No	No	0	8	4
953	A:A:F312	A:A:I308	67.5713	2.51	No	No	0	8	7
954	A:A:F345	A:A:L270	60.8947	3.65	Yes	Yes	3	8	6
955	A:A:I348	A:A:L270	20.3011	4.28	Yes	Yes	3	4	6
956	A:A:F273	A:A:I348	40.6022	5.02	Yes	Yes	3	9	4
957	A:A:L270	A:A:N271	40.5977	4.12	Yes	No	0	6	5
958	A:A:I348	A:A:K274	10.151	13.09	Yes	No	3	4	5
959	A:A:F273	A:A:W277	81.1247	5.01	Yes	Yes	3	9	6
960	A:A:F273	A:A:S349	50.7227	2.64	Yes	Yes	3	9	7
961	A:A:N278	A:A:W277	20.3261	5.65	No	Yes	0	8	6
962	A:A:H357	A:A:W277	20.3261	29.62	No	Yes	0	7	6
963	A:A:C359	A:A:W277	30.536	2.61	No	Yes	3	5	6
964	A:A:C359	A:A:S349	30.4219	6.89	No	Yes	3	5	7
965	A:A:N278	A:A:S352	10.1631	5.96	No	No	0	8	5
966	A:A:W281	B:B:D290	12.4017	7.82	Yes	No	3	5	6
967	A:A:S286	A:A:Y360	13.5732	2.54	No	Yes	13	8	8
968	A:A:I288	A:A:Y360	40.6514	2.42	Yes	Yes	13	9	8
969	A:A:D378	A:A:I288	13.5505	12.59	No	Yes	13	7	9
970	A:A:H362	A:A:I288	27.0117	6.63	Yes	Yes	13	9	9
971	A:A:F290	A:A:R374	20.3054	2.14	Yes	Yes	13	9	4
972	A:A:H362	A:A:R374	20.2591	11.28	Yes	Yes	13	9	4
973	A:A:L291	A:A:R342	100	2.43	Yes	Yes	3	8	4
974	A:A:F363	A:A:L291	100	9.74	Yes	Yes	3	5	8
975	A:A:L297	A:A:Q294	84.4651	2.66	No	No	0	8	6
976	A:A:F363	A:A:K338	61.191	22.33	Yes	Yes	3	5	5
977	A:A:C365	A:A:Q294	67.8107	6.1	Yes	No	0	8	6
978	A:A:C365	A:A:D295	16.9527	3.11	Yes	No	0	8	9
979	A:A:A298	A:A:L302	60.8932	3.15	No	Yes	33	4	2
980	A:A:D331	A:A:L302	100	4.07	Yes	Yes	33	4	2
981	A:A:D331	A:A:P332	100	6.44	Yes	No	0	4	1
982	A:A:P332	A:A:R336	100	5.76	No	No	0	1	5
983	A:A:R336	A:A:Y318	100	2.06	No	Yes	0	5	6
984	A:A:Y318	A:A:Y339	100	20.85	Yes	Yes	3	6	3
985	A:A:R342	A:A:Y339	100	6.17	Yes	Yes	3	4	3
986	A:A:A298	A:A:V334	77.7737	5.09	No	Yes	33	4	4
987	A:A:D331	A:A:V334	100	5.84	Yes	Yes	33	4	4
988	A:A:F363	A:A:Y339	100	2.06	Yes	Yes	3	5	3
989	A:A:V301	A:A:V334	33.7626	4.81	No	Yes	0	7	4
990	A:A:A337	A:A:V301	50.7774	5.09	No	No	0	8	7
991	A:A:A337	A:A:F315	67.7921	2.77	No	No	0	8	6
992	A:A:F315	A:A:I308	84.444	27.63	No	No	0	6	7
993	A:A:E299	A:A:L302	60.8936	2.65	No	Yes	0	6	2
994	A:A:K300	A:A:K305	16.8928	8.62	Yes	No	54	9	3
995	A:A:K300	A:A:S306	16.8928	3.06	Yes	No	54	9	7
996	A:A:A303	A:A:G304	16.8929	1.95	No	No	0	5	5
997	A:A:G304	A:A:K307	33.7857	5.23	No	No	0	5	6
998	A:A:E309	A:A:K307	50.6786	2.7	No	No	0	4	6
999	A:A:D310	A:A:E309	100	5.2	No	No	0	3	4
1000	A:A:D310	A:A:Y311	100	4.6	No	No	0	3	6
1001	A:A:F312	A:A:P313	16.8928	4.33	No	No	0	8	6
1002	A:A:F340	A:A:Y318	100	3.09	Yes	Yes	3	7	6
1003	A:A:E314	A:A:R317	33.7857	1.16	No	No	0	6	2
1004	A:A:A316	A:A:E314	50.6786	1.51	No	No	0	2	6
1005	A:A:A316	A:A:E309	67.5714	1.51	No	No	0	2	4
1006	A:A:R317	A:A:T319	16.8929	5.17	No	No	0	2	5
1007	A:A:K343	A:A:Y318	60.8948	28.66	No	Yes	3	3	6
1008	A:A:D331	A:A:R333	60.8952	4.76	Yes	No	0	4	5
1009	A:A:K338	A:A:T335	30.4456	3	Yes	No	3	5	4
1010	A:A:T335	A:A:Y339	60.8933	2.5	No	Yes	3	4	3
1011	A:A:E344	A:A:F340	60.8936	12.83	No	Yes	0	5	7
1012	A:A:C359	A:A:P361	40.655	3.77	No	No	0	5	5
1013	A:A:P361	A:A:V346	20.3035	3.53	No	No	0	5	4
1014	A:A:S349	A:A:T350	10.1534	3.2	Yes	No	0	7	4
1015	A:A:G353	A:A:H357	10.1631	3.18	No	No	0	4	7
1016	A:A:D354	A:A:R356	12.4024	4.76	No	No	0	3	2
1017	A:A:C365	A:A:V367	16.9527	3.42	Yes	No	0	8	9
1018	A:A:D368	A:A:R374	13.5171	4.76	No	Yes	13	9	4
1019	A:A:E370	A:A:R374	13.5304	12.79	No	Yes	13	4	4
1020	B:B:E3	B:B:L7	24.7811	13.25	No	Yes	0	5	8
1021	B:B:L7	G:G:L15	37.1715	2.77	Yes	Yes	34	8	2
1022	B:B:A11	G:G:L15	100	4.73	No	Yes	0	5	2
1023	B:B:A11	B:B:K15	100	1.61	No	No	0	5	6
1024	B:B:K15	G:G:L19	100	8.46	No	No	0	6	9
1025	G:G:L19	G:G:Q18	100	2.66	No	No	0	9	9
1026	B:B:C218	G:G:Q18	100	7.63	No	No	0	5	9
1027	B:B:C218	B:B:K209	100	9.7	No	Yes	6	5	6
1028	B:B:H183	B:B:K209	100	14.41	Yes	Yes	6	9	6
1029	B:B:D205	B:B:H183	100	2.52	Yes	Yes	6	9	9
1030	B:B:D205	B:B:G185	100	5.03	Yes	No	0	9	5
1031	B:B:C204	B:B:G185	100	1.96	Yes	No	0	7	5
1032	B:B:C218	B:B:W211	100	5.22	No	Yes	6	5	8
1033	B:B:H183	B:B:W211	100	3.17	Yes	Yes	6	9	8
1034	B:B:E3	B:B:S2	12.3906	4.31	No	No	0	5	5
1035	B:B:L4	G:G:Q11	37.1718	2.66	No	Yes	0	4	3
1036	G:G:L15	G:G:Q11	61.9527	6.65	Yes	Yes	34	2	3
1037	B:B:L4	B:B:R8	24.7812	2.43	No	No	0	4	3
1038	B:B:D5	B:B:Q6	12.3906	9.14	No	No	0	1	1
1039	B:B:E10	B:B:Q6	24.7812	2.55	Yes	No	0	8	1
1040	B:B:E10	G:G:L15	86.7337	3.98	Yes	Yes	34	8	2
1041	B:B:Q9	B:B:R8	12.3906	2.34	No	No	0	3	3
1042	B:B:E12	B:B:N16	12.3906	9.2	No	No	0	4	1
1043	B:B:N16	B:B:Q17	24.7812	6.6	No	No	0	1	4
1044	B:B:Q13	B:B:Q17	37.1718	2.56	No	No	0	1	4
1045	B:B:E10	B:B:Q13	49.5624	1.27	Yes	No	0	8	1
1046	B:B:L14	G:G:L19	37.1717	4.15	No	No	0	8	9
1047	B:B:L14	G:G:K20	24.7811	9.87	No	No	0	8	6
1048	B:B:I18	G:G:E22	24.8022	6.83	No	Yes	0	7	9
1049	B:B:T221	G:G:E22	100	8.47	No	Yes	0	7	9
1050	B:B:K209	B:B:T221	100	9.01	Yes	No	0	6	7
1051	B:B:I18	B:B:R19	12.4011	2.51	No	No	0	7	4
1052	B:B:F222	B:B:F241	100	6.43	Yes	Yes	3	8	6
1053	B:B:F241	B:B:T243	100	3.89	Yes	Yes	3	6	8
1054	B:B:H225	B:B:T243	100	6.85	Yes	Yes	3	9	8
1055	B:B:H225	B:B:S245	100	15.34	Yes	Yes	3	9	9
1056	B:B:D246	B:B:S245	100	4.42	Yes	Yes	3	9	9
1057	B:B:D228	B:B:D246	100	11.98	Yes	Yes	3	9	9
1058	B:B:F222	B:B:F253	100	13.93	Yes	Yes	3	8	6
1059	B:B:F253	B:B:T243	100	7.78	Yes	Yes	3	6	8
1060	B:B:F253	B:B:R251	100	2.14	Yes	Yes	3	6	8
1061	B:B:H225	B:B:R251	100	18.05	Yes	Yes	3	9	8
1062	B:B:I229	B:B:T243	100	3.04	Yes	Yes	3	7	8
1063	B:B:I229	B:B:S245	100	3.1	Yes	Yes	3	7	9
1064	B:B:D247	B:B:H225	100	10.08	Yes	Yes	3	9	9
1065	B:B:D247	B:B:S227	100	2.94	Yes	No	3	9	6
1066	B:B:D228	B:B:S227	100	2.94	Yes	No	3	9	6
1067	B:B:R251	B:B:T249	100	6.47	Yes	Yes	3	8	6
1068	B:B:D247	B:B:T249	100	5.78	Yes	Yes	3	9	6
1069	B:B:D246	B:B:N230	100	6.73	Yes	No	0	9	9
1070	B:B:F222	B:B:R22	100	2.14	Yes	Yes	3	8	6
1071	B:B:R22	G:G:E22	24.83	3.49	Yes	Yes	3	6	9
1072	B:B:D258	B:B:F222	100	9.55	Yes	Yes	3	7	8
1073	B:B:D258	G:G:E22	18.6318	2.6	Yes	Yes	3	7	9
1074	B:B:Q259	B:B:R22	100	3.5	No	Yes	0	6	6
1075	B:B:A26	B:B:Q259	100	4.55	No	No	0	3	6
1076	B:B:A26	B:B:K23	92.8944	3.21	No	No	0	3	2
1077	B:B:C25	G:G:R27	92.8961	2.79	No	No	0	3	8
1078	B:B:D258	G:G:R27	100	8.34	Yes	No	0	7	8
1079	B:B:L261	B:B:L30	100	5.54	Yes	Yes	3	5	5
1080	B:B:D254	B:B:L261	100	2.71	Yes	Yes	3	9	5
1081	B:B:D254	B:B:R256	100	7.15	Yes	Yes	3	9	9
1082	B:B:N239	B:B:R256	100	14.46	No	Yes	0	2	9
1083	B:B:N237	B:B:N239	100	6.81	Yes	No	0	5	2
1084	B:B:G238	B:B:N237	100	3.39	No	Yes	3	7	5
1085	B:B:F234	B:B:G238	100	3.01	Yes	No	3	5	7
1086	B:B:F234	B:B:F241	100	3.22	Yes	Yes	3	5	6
1087	B:B:L30	B:B:T34	93.0952	4.42	Yes	No	0	5	5
1088	B:B:L252	B:B:L261	30.9663	5.54	No	Yes	3	7	5
1089	B:B:L252	B:B:Y264	30.9966	7.03	No	Yes	3	7	5
1090	B:B:L285	B:B:Y264	100	2.34	No	Yes	3	6	5
1091	B:B:F278	B:B:L285	100	15.83	Yes	No	3	7	6
1092	B:B:F235	B:B:F278	100	6.43	Yes	Yes	3	6	7
1093	B:B:F235	B:B:N237	100	12.08	Yes	Yes	3	6	5
1094	B:B:M262	B:B:Y264	61.961	5.99	Yes	Yes	3	4	5
1095	B:B:L300	B:B:T34	62.1353	11.79	Yes	No	0	6	5
1096	B:B:L300	B:B:R283	12.5239	9.72	Yes	Yes	0	6	9
1097	B:B:R283	G:G:L51	68.2593	6.07	Yes	Yes	26	9	6
1098	G:G:D48	G:G:L51	100	8.14	Yes	Yes	0	9	6
1099	G:G:D48	G:G:P49	100	4.83	Yes	Yes	0	9	7
1100	B:B:M325	G:G:P49	100	3.35	Yes	Yes	5	5	7
1101	B:B:M325	G:G:P60	100	5.03	Yes	Yes	5	5	9
1102	B:B:Y85	G:G:P60	100	9.74	No	Yes	5	4	9
1103	B:B:R68	B:B:Y85	100	24.69	No	No	0	5	4
1104	B:B:D66	B:B:R68	100	2.38	No	No	0	8	5
1105	B:B:D66	B:B:L69	100	10.86	No	Yes	0	8	5
1106	B:B:L69	B:B:Y105	100	8.21	Yes	Yes	15	5	6
1107	B:B:V71	B:B:Y105	100	7.57	Yes	Yes	0	8	6
1108	B:B:L79	B:B:V71	100	4.47	No	Yes	0	7	8
1109	B:B:C114	B:B:L79	100	4.76	Yes	No	15	8	7
1110	B:B:L300	G:G:C41	12.4489	4.76	Yes	No	0	6	7
1111	B:B:S281	G:G:C41	31.0309	3.44	No	No	0	9	7
1112	B:B:S281	G:G:D48	37.2277	5.89	No	Yes	0	9	9
1113	B:B:I37	B:B:R283	18.5908	3.76	No	Yes	0	2	9
1114	B:B:L300	G:G:M38	43.3506	2.83	Yes	No	0	6	4
1115	G:G:C41	G:G:E42	12.3903	3.04	No	No	0	7	1
1116	B:B:I43	B:B:M45	37.213	4.37	Yes	Yes	0	3	4
1117	B:B:M45	B:B:N340	100	7.01	Yes	No	0	4	9
1118	B:B:N340	B:B:R48	100	6.03	No	No	0	9	7
1119	B:B:R48	G:G:F61	100	4.28	No	Yes	0	7	8
1120	B:B:Y85	G:G:F61	100	8.25	No	Yes	5	4	8
1121	B:B:I43	B:B:V40	18.621	3.07	Yes	Yes	0	3	3
1122	B:B:V40	G:G:L51	18.5928	2.98	Yes	Yes	26	3	6
1123	B:B:D298	B:B:V40	24.7911	2.92	Yes	Yes	26	9	3
1124	B:B:D298	B:B:R283	12.3975	2.38	Yes	Yes	26	9	9
1125	B:B:Q44	B:B:R46	12.4003	3.5	No	No	0	4	5
1126	B:B:R46	B:B:R48	18.6004	2.13	No	No	0	5	7
1127	B:B:M45	B:B:V296	55.7869	4.56	Yes	Yes	0	4	5
1128	B:B:L308	B:B:M45	12.4355	5.65	No	Yes	0	7	4
1129	B:B:H311	B:B:K337	100	14.41	Yes	Yes	14	9	6
1130	B:B:G330	B:B:H311	100	3.18	No	Yes	0	5	9
1131	B:B:C317	B:B:G330	100	3.92	No	No	0	7	5
1132	B:B:C317	B:B:I58	100	3.27	No	Yes	0	7	9
1133	B:B:H54	B:B:I58	100	6.63	Yes	Yes	5	9	9
1134	B:B:G330	B:B:L336	100	3.42	No	Yes	0	5	7
1135	B:B:I58	B:B:L336	100	5.71	Yes	Yes	0	9	7
1136	B:B:L336	B:B:S72	100	3	Yes	Yes	0	7	9
1137	B:B:H54	B:B:S72	100	6.97	Yes	Yes	5	9	9
1138	B:B:I58	B:B:S74	100	3.1	Yes	No	5	9	9
1139	B:B:D76	B:B:S74	100	10.31	Yes	No	5	9	9
1140	B:B:K337	B:B:T47	30.9769	4.5	Yes	No	14	6	3
1141	B:B:T329	B:B:W339	30.9861	9.7	Yes	Yes	14	8	9
1142	B:B:H311	B:B:T329	100	5.48	Yes	Yes	14	9	8
1143	B:B:K337	B:B:W339	30.9943	8.12	Yes	Yes	14	6	9
1144	B:B:L51	B:B:W82	12.4245	13.67	No	Yes	0	9	9
1145	B:B:K89	B:B:W82	80.611	10.44	Yes	Yes	5	9	9
1146	B:B:R52	B:B:T50	30.9838	7.76	No	No	14	7	3
1147	B:B:K337	B:B:T50	61.9692	10.51	Yes	No	14	6	3
1148	B:B:F335	B:B:R52	30.9808	10.69	No	No	14	4	7
1149	B:B:D333	B:B:F335	61.9631	8.36	Yes	No	14	9	4
1150	B:B:D333	B:B:H311	100	8.82	Yes	Yes	14	9	9
1151	B:B:A73	B:B:C103	12.3958	3.61	No	No	0	9	8
1152	B:B:A73	B:B:V100	18.5911	3.39	No	No	0	9	9
1153	B:B:G115	B:B:V100	37.1815	1.84	Yes	No	0	9	9
1154	B:B:C317	B:B:M61	100	9.73	No	No	0	7	6
1155	B:B:G319	B:B:M61	100	3.49	No	No	0	5	6
1156	B:B:H62	B:B:Y105	25.15	4.36	No	Yes	0	6	6
1157	B:B:H62	B:B:R150	18.9578	12.41	No	Yes	0	6	6
1158	B:B:L70	B:B:W82	62.03	9.11	No	Yes	5	5	9
1159	B:B:L70	B:B:W63	49.633	5.69	No	Yes	5	5	7
1160	B:B:T321	B:B:W63	37.2478	16.98	Yes	Yes	5	7	7
1161	B:B:S67	B:B:T321	12.3972	7.99	No	Yes	5	5	7
1162	B:B:D323	B:B:S67	12.3968	8.83	No	No	5	7	5
1163	B:B:D323	B:B:M325	18.5987	8.32	No	Yes	5	7	5
1164	B:B:D83	B:B:R68	12.4137	16.68	No	No	0	8	5
1165	B:B:G77	B:B:L95	12.3973	5.13	No	Yes	0	8	8
1166	B:B:L95	B:B:V100	12.3982	4.47	Yes	No	0	8	9
1167	B:B:C114	B:B:L95	12.3938	4.76	Yes	Yes	15	8	8
1168	B:B:D118	B:B:G116	12.4047	1.68	No	No	0	9	9
1169	B:B:G115	B:B:T102	55.7304	1.82	Yes	No	0	9	8
1170	B:B:C149	B:B:T102	49.5289	8.45	No	No	0	8	8
1171	B:B:G109	B:B:Y105	12.5295	2.9	No	Yes	0	5	6
1172	B:B:A106	B:B:F151	12.3877	8.32	No	Yes	3	6	9
1173	B:B:F151	B:B:I157	100	5.02	Yes	Yes	3	9	7
1174	B:B:I157	B:B:T159	100	3.04	Yes	Yes	3	7	9
1175	B:B:H142	B:B:T159	100	2.74	Yes	Yes	3	9	9
1176	B:B:H142	B:B:S161	100	13.95	Yes	Yes	3	9	9
1177	B:B:L146	B:B:T159	100	2.95	No	Yes	3	7	9
1178	B:B:G115	B:B:L146	100	3.42	Yes	No	0	9	7
1179	B:B:F151	B:B:P107	24.7754	2.89	Yes	No	3	9	6
1180	B:B:D154	B:B:Y111	24.864	9.2	No	Yes	3	6	4
1181	B:B:I123	B:B:Y111	100	3.63	Yes	Yes	3	6	4
1182	B:B:I123	B:B:I157	100	5.89	Yes	Yes	3	6	7
1183	B:B:F151	B:B:Y111	100	3.09	Yes	Yes	3	9	4
1184	B:B:N110	B:B:Y111	49.5293	11.63	Yes	Yes	3	4	4
1185	B:B:N125	B:B:Y111	100	15.12	Yes	Yes	3	4	4
1186	B:B:K127	B:B:N110	24.7687	8.39	No	Yes	0	4	4
1187	B:B:S136	B:B:Y111	100	6.36	No	Yes	3	4	4
1188	B:B:A113	B:B:F151	12.3877	4.16	No	Yes	0	9	9
1189	B:B:E138	B:B:S122	24.8089	5.75	No	No	0	6	8
1190	B:B:S122	B:B:Y124	31.0111	10.17	No	Yes	15	8	6
1191	B:B:E138	B:B:I120	18.6067	4.1	No	No	0	6	6
1192	B:B:A140	B:B:I120	12.4045	4.87	No	No	0	5	6
1193	B:B:C121	B:B:C149	43.3303	5.46	No	No	3	8	8
1194	B:B:C121	B:B:T159	86.6848	3.38	No	Yes	3	8	9
1195	B:B:C121	B:B:L139	100	4.76	No	Yes	0	8	9
1196	B:B:L139	B:B:W169	74.3039	12.53	Yes	Yes	0	9	8
1197	B:B:T159	B:B:W169	100	8.49	Yes	Yes	3	9	8
1198	B:B:I123	B:B:I171	37.1594	4.42	Yes	Yes	3	6	6
1199	B:B:F151	B:B:I171	37.1641	3.77	Yes	Yes	3	9	6
1200	B:B:N125	B:B:R134	100	4.82	Yes	Yes	3	4	3
1201	B:B:R134	B:B:S136	100	2.64	Yes	No	3	3	4
1202	B:B:E130	B:B:T128	49.5471	2.82	No	No	0	3	3
1203	B:B:R134	B:B:T128	100	2.59	Yes	No	0	3	3
1204	B:B:E130	B:B:N132	49.5471	9.2	No	No	0	3	3
1205	B:B:N132	B:B:R134	99.0942	2.41	No	Yes	0	3	3
1206	B:B:G131	B:B:T128	49.5471	1.82	No	No	0	4	3
1207	B:B:L139	B:B:R137	100	3.64	Yes	No	0	9	5
1208	B:B:G174	B:B:R137	100	3	No	No	0	4	5
1209	B:B:H142	B:B:T165	24.7976	5.48	Yes	No	3	9	7
1210	B:B:D163	B:B:T165	24.7877	11.56	Yes	No	3	9	7
1211	B:B:C148	B:B:L190	18.5799	3.17	No	Yes	6	6	5
1212	B:B:L190	B:B:S160	24.8081	6.01	Yes	Yes	6	5	6
1213	B:B:S160	B:B:V187	49.5746	6.46	Yes	Yes	6	6	9
1214	B:B:H183	B:B:V187	37.175	5.54	Yes	Yes	6	9	9
1215	B:B:F199	B:B:L190	12.5663	6.09	Yes	Yes	6	9	5
1216	B:B:F199	B:B:W211	68.4585	12.03	Yes	Yes	6	9	8
1217	B:B:A203	B:B:V187	37.1695	3.39	No	Yes	6	8	9
1218	B:B:A203	B:B:D205	43.3606	3.09	No	Yes	6	8	9
1219	B:B:F199	B:B:L192	24.9557	2.44	Yes	No	0	9	5
1220	B:B:D153	B:B:L152	18.5863	4.07	No	Yes	6	5	3
1221	B:B:L152	B:B:V158	18.5847	4.47	Yes	No	6	3	5
1222	B:B:F199	B:B:V158	24.7795	3.93	Yes	No	6	9	5
1223	B:B:L152	B:B:L192	18.5992	8.3	Yes	No	0	3	5
1224	B:B:L152	B:B:V213	18.5861	2.98	Yes	No	0	3	4
1225	B:B:F180	B:B:V213	24.7798	2.62	Yes	No	0	7	4
1226	B:B:F180	B:B:W211	86.768	14.03	Yes	Yes	6	7	8
1227	B:B:L168	B:B:Q156	12.3969	2.66	Yes	No	6	6	5
1228	B:B:F180	B:B:L168	31.0066	2.44	Yes	Yes	6	7	6
1229	B:B:L152	B:B:T196	18.5865	4.42	Yes	No	0	3	1
1230	B:B:I171	B:B:N155	49.5426	4.25	Yes	No	0	6	3
1231	B:B:E172	B:B:N155	24.7713	7.89	No	No	0	6	3
1232	B:B:C166	B:B:V187	12.387	5.12	Yes	Yes	6	8	9
1233	B:B:H183	B:B:S201	12.3873	2.79	Yes	Yes	6	9	9
1234	B:B:T165	B:B:T181	37.189	3.14	No	No	0	7	2
1235	B:B:L168	B:B:T177	12.4254	4.42	Yes	No	6	6	4
1236	B:B:T177	B:B:T178	12.4203	4.71	No	Yes	6	4	4
1237	B:B:F180	B:B:T178	18.617	6.49	Yes	Yes	6	7	4
1238	B:B:Q176	B:B:W169	24.7818	6.57	No	Yes	0	4	8
1239	B:B:D170	B:B:T173	31.0059	8.67	No	No	0	9	5
1240	B:B:G174	B:B:T173	92.9026	1.82	No	No	0	4	5
1241	B:B:D170	B:B:T177	12.4495	5.78	No	No	0	9	4
1242	B:B:Q175	B:B:T173	30.9665	4.25	No	No	0	4	5
1243	B:B:Q176	B:B:T179	12.3909	5.67	No	No	0	4	4
1244	B:B:G182	B:B:T181	24.7927	3.64	No	No	0	6	2
1245	B:B:G182	G:G:K14	12.3963	3.49	No	No	0	6	4
1246	B:B:I232	B:B:T243	100	3.04	Yes	Yes	3	8	8
1247	B:B:I232	B:B:S189	30.9805	3.1	Yes	No	0	8	7
1248	B:B:F234	B:B:S191	30.9722	5.28	Yes	No	0	5	8
1249	B:B:A193	B:B:F234	92.9166	5.55	No	Yes	3	4	5
1250	B:B:F234	B:B:P194	30.9702	5.78	Yes	No	3	5	4
1251	B:B:A193	B:B:D195	61.9477	3.09	No	No	0	4	5
1252	B:B:D195	B:B:R197	30.9739	14.29	No	No	0	5	5
1253	B:B:L198	B:B:L210	100	4.15	No	Yes	3	3	5
1254	B:B:L210	B:B:V200	100	4.47	Yes	Yes	3	5	6
1255	B:B:I232	B:B:V200	100	4.61	Yes	Yes	3	8	6
1256	B:B:F241	B:B:V200	100	11.8	Yes	Yes	3	6	6
1257	B:B:L210	B:B:L255	100	6.92	Yes	Yes	3	5	6
1258	B:B:F241	B:B:L255	100	2.44	Yes	Yes	3	6	6
1259	B:B:D212	B:B:L198	100	5.43	Yes	No	3	9	3
1260	B:B:D212	B:B:R219	100	9.53	Yes	Yes	3	9	5
1261	B:B:L210	B:B:R219	100	4.86	Yes	Yes	3	5	5
1262	B:B:Q220	B:B:R219	100	3.5	Yes	Yes	3	7	5
1263	B:B:L255	B:B:Q220	100	2.66	Yes	Yes	3	6	7
1264	B:B:F222	B:B:Q220	100	10.54	Yes	Yes	3	8	7
1265	B:B:Q220	G:G:E22	43.5624	3.82	Yes	Yes	3	7	9
1266	B:B:A208	B:B:G202	12.3936	1.95	No	No	0	6	6
1267	B:B:G202	B:B:I229	24.7755	3.53	No	Yes	0	6	7
1268	B:B:D212	B:B:E215	100	22.09	Yes	No	0	9	3
1269	B:B:E215	B:B:M217	100	8.12	No	No	0	3	3
1270	B:B:Q220	G:G:I25	100	2.74	Yes	No	0	7	2
1271	B:B:F253	B:B:G224	55.7511	3.01	Yes	No	0	6	6
1272	B:B:A231	B:B:V276	30.9662	3.39	No	No	55	5	6
1273	B:B:C233	B:B:V276	100	5.12	No	No	0	3	6
1274	B:B:C233	B:B:F278	100	4.19	No	Yes	0	3	7
1275	B:B:G244	B:B:V276	100	1.84	Yes	No	55	5	6
1276	B:B:F235	B:B:P236	30.9688	8.67	Yes	Yes	3	6	7
1277	B:B:P236	G:G:Y40	30.9786	5.56	Yes	Yes	3	7	6
1278	B:B:N237	G:G:Y40	100	8.14	Yes	Yes	3	5	6
1279	B:B:A240	B:B:F235	30.9728	4.16	No	Yes	3	6	6
1280	B:B:A240	G:G:L37	30.9693	4.73	No	No	3	6	7
1281	B:B:N237	G:G:L37	61.9399	4.12	Yes	No	3	5	7
1282	B:B:F235	B:B:G282	30.9688	6.02	Yes	No	3	6	9
1283	B:B:A242	B:B:F278	30.9692	2.77	No	Yes	3	4	7
1284	B:B:C250	B:B:G244	30.968	3.92	No	Yes	0	8	5
1285	B:B:G244	B:B:I273	100	3.53	Yes	No	0	5	6
1286	B:B:E260	B:B:R251	24.7752	10.47	No	Yes	3	6	8
1287	B:B:R251	B:B:T263	24.782	6.47	Yes	No	3	8	1
1288	B:B:A257	B:B:D254	30.9701	4.63	No	Yes	0	7	9
1289	B:B:R256	G:G:A33	30.9688	4.15	Yes	No	3	9	7
1290	B:B:R256	G:G:I28	92.9149	8.77	Yes	No	0	9	4
1291	B:B:R256	G:G:D36	92.9149	5.96	Yes	No	0	9	5
1292	B:B:L261	G:G:V30	61.9389	2.98	Yes	No	0	5	8
1293	B:B:A302	B:B:Y264	30.9657	2.67	No	Yes	3	2	5
1294	B:B:A299	B:B:Y264	30.9733	4	No	Yes	0	5	5
1295	B:B:H266	B:B:I269	30.9667	3.98	No	Yes	19	4	4
1296	B:B:I269	B:B:Y289	92.892	3.63	Yes	Yes	19	4	7
1297	B:B:I273	B:B:Y289	100	13.3	No	Yes	0	6	7
1298	B:B:I269	B:B:N268	30.9667	7.08	Yes	No	19	4	4
1299	B:B:N295	B:B:R304	37.1577	9.64	Yes	No	19	6	5
1300	B:B:N295	B:B:Y289	61.9605	13.96	Yes	Yes	19	6	7
1301	B:B:R304	B:B:W297	30.9632	2	No	Yes	19	5	8
1302	B:B:W297	B:B:Y289	61.9272	7.72	Yes	Yes	19	8	7
1303	B:B:N295	B:B:V307	12.4338	2.96	Yes	No	0	6	3
1304	B:B:G306	B:B:V307	37.2285	1.84	No	No	0	4	3
1305	B:B:G306	B:B:V296	43.4255	1.84	No	Yes	0	4	5
1306	B:B:C271	B:B:D291	30.9667	7.78	No	No	0	5	8
1307	B:B:D291	B:B:Y289	61.981	2.3	No	Yes	0	8	7
1308	B:B:G288	B:B:V315	92.9325	1.84	No	No	0	7	7
1309	B:B:H311	B:B:V315	100	4.15	Yes	No	14	9	7
1310	B:B:G288	B:B:S275	30.979	1.86	No	No	0	7	8
1311	B:B:L318	B:B:S275	43.3748	7.51	Yes	No	0	6	8
1312	B:B:L318	B:B:T329	92.9488	2.95	Yes	Yes	14	6	8
1313	B:B:L318	B:B:S277	37.1768	3	Yes	Yes	14	6	5
1314	B:B:G319	B:B:S277	99.1605	1.86	No	Yes	0	5	5
1315	B:B:L286	B:B:S277	37.2124	4.5	Yes	Yes	14	7	5
1316	B:B:S277	B:B:V320	12.4024	4.85	Yes	No	0	5	7
1317	B:B:G324	B:B:V320	12.4072	1.84	Yes	No	0	9	7
1318	B:B:G324	B:B:T321	18.6681	1.82	Yes	Yes	0	9	7
1319	B:B:G324	G:G:P49	18.6402	2.03	Yes	Yes	0	9	7
1320	B:B:L286	B:B:S279	24.8084	4.5	Yes	No	0	7	9
1321	B:B:S279	G:G:L50	12.3968	3	No	No	0	9	9
1322	B:B:G324	B:B:K280	12.4346	3.49	Yes	No	0	9	1
1323	B:B:K301	B:B:R283	18.5972	4.95	Yes	Yes	26	5	9
1324	B:B:T329	B:B:V327	30.9941	3.17	Yes	No	14	8	6
1325	B:B:A287	B:B:Y289	30.9668	4	No	Yes	19	6	7
1326	B:B:C294	B:B:G288	30.983	3.92	No	No	0	5	7
1327	B:B:C294	B:B:L318	43.3703	3.17	No	Yes	0	5	6
1328	B:B:N293	B:B:V307	18.5984	5.91	No	No	0	5	3
1329	B:B:N313	B:B:W332	12.4051	7.91	No	Yes	0	7	9
1330	B:B:A309	B:B:N293	12.4307	3.13	No	No	0	3	5
1331	B:B:D298	B:B:D303	18.5941	10.65	Yes	No	26	9	2
1332	B:B:H311	B:B:S331	30.9875	12.55	Yes	No	14	9	9
1333	B:B:D312	B:B:D333	30.9876	10.65	No	Yes	0	5	9
1334	B:B:M325	G:G:V54	24.7893	3.04	Yes	Yes	5	5	6
1335	G:G:N59	G:G:V54	49.588	5.91	No	Yes	5	9	6
1336	G:G:N59	G:G:P60	30.9858	4.89	No	Yes	5	9	9
1337	G:G:F61	G:G:N59	30.9977	2.42	Yes	No	5	8	9
1338	G:G:I9	G:G:R13	12.3906	5.01	No	No	0	2	6
1339	G:G:E17	G:G:R13	24.7811	10.47	No	No	0	6	6
1340	G:G:E17	G:G:V16	37.1717	1.43	No	No	0	6	7
1341	G:G:L15	G:G:V16	49.5623	1.49	Yes	No	0	2	7
1342	G:G:K20	G:G:N24	12.3906	2.8	No	No	0	6	1
1343	G:G:I28	G:G:K32	61.9433	2.91	No	No	0	4	5
1344	G:G:D36	G:G:K32	61.9433	4.15	No	No	0	5	5
1345	G:G:H44	G:G:Y40	61.9544	17.42	No	Yes	0	6	6
1346	G:G:A43	G:G:H44	30.9772	2.93	No	No	0	4	6
1347	G:G:E58	G:G:V54	55.7847	2.85	No	Yes	0	5	6
1348	G:G:E58	G:G:P55	37.1898	4.72	No	No	0	5	5
1349	A:A:A366	A:A:C365	16.9527	1.81	No	Yes	0	9	8
1350	G:G:P55	G:G:S57	18.5949	1.78	No	No	0	5	6
1351	S:S:G94	S:S:I33	10.3482	1.76	No	No	0	9	5
1352	B:B:P107	B:B:T65	12.3877	1.75	No	No	0	6	1
1353	G:G:L51	G:G:T52	12.3988	1.47	Yes	No	0	6	4
1354	S:S:A86	S:S:S84	20.6295	1.71	No	No	0	3	6
1355	S:S:A321	S:S:S490	20.6244	1.71	Yes	No	0	5	8
1356	S:S:G346	S:S:N345	20.6366	1.7	No	Yes	0	3	8
1357	B:B:A28	G:G:V30	30.9695	1.7	No	No	0	4	8
1358	S:S:E564	S:S:G553	36.112	1.64	No	No	0	6	6
1359	B:B:S147	B:B:S160	12.3895	1.63	No	Yes	0	9	6
1360	B:B:I33	G:G:A34	61.939	1.62	No	No	0	3	6
1361	B:B:L30	G:G:A34	92.9084	1.58	Yes	No	0	5	6
1362	B:B:I33	G:G:A35	30.9695	1.62	No	No	0	3	2
1363	S:S:I139	S:S:S137	20.6331	1.55	Yes	No	0	5	4
1364	B:B:M262	B:B:S31	30.9693	1.53	Yes	No	0	4	1
1365	G:G:K32	G:G:S31	61.9433	1.53	No	No	0	5	9
1366	S:S:C482	S:S:E481	23.7218	1.52	No	No	0	7	4
1367	G:G:A12	G:G:Q11	12.3906	1.52	No	Yes	0	5	3
1368	S:S:F479	S:S:G483	41.2411	1.51	Yes	No	0	8	7
1369	A:A:L266	A:A:S250	47.326	1.5	No	No	0	8	6
1370	S:S:N400	S:S:S403	20.6314	1.49	No	No	0	4	2
1371	B:B:D322	B:B:S67	12.397	1.47	No	No	0	1	5
1372	B:B:A206	B:B:H225	18.5913	1.46	No	Yes	0	4	9
1373	B:B:Q75	B:B:S98	12.3886	1.44	Yes	No	0	9	8
1374	A:A:K28	A:A:N29	12.4092	1.4	No	No	0	4	4
1375	A:A:E32	A:A:K28	18.6138	1.35	No	No	0	3	4
1376	A:A:D223	A:A:F208	10.1409	1.19	No	No	0	9	5
1377	A:A:D229	A:A:R231	16.3255	1.19	No	Yes	0	8	9
1378	B:B:D212	B:B:R214	100	1.19	Yes	No	0	9	9
1379	S:S:R25	S:S:Y20	82.4694	11.32	Yes	No	0	4	2
1380	S:S:Q27	S:S:R96	41.2371	10.51	No	Yes	2	4	4
1381	R:R:L123	R:R:L125	10.3486	4.15	No	Yes	0	5	4
1382	R:R:L125	S:S:S132	10.3334	3	Yes	No	36	4	4
1383	R:R:F270	R:R:Y218	100	2.06	Yes	Yes	1	7	7
1384	R:R:N176	R:R:N178	100	8.17	No	No	0	6	3
1385	R:R:I292	R:R:W530	100	2.35	Yes	Yes	1	7	8
1386	R:R:F204	R:R:W206	100	13.03	Yes	Yes	1	7	9
1387	R:R:F114	R:R:R96	56.8423	4.28	Yes	Yes	1	5	4
1388	R:R:N64	R:R:R66	20.709	3.62	Yes	Yes	1	4	5
1389	R:R:L157	R:R:T111	19.8121	2.95	Yes	No	1	7	7
1390	R:R:E297	R:R:Q193	100	5.1	No	Yes	0	8	9
1391	R:R:F239	R:R:I267	100	3.77	Yes	Yes	1	6	7
1392	R:R:D216	R:R:Y218	34.1339	3.45	No	Yes	1	6	7
1393	R:R:V284	R:R:V313	18.567	6.41	No	Yes	1	3	3
1394	R:R:G315	R:R:G316	15.4617	2.11	No	No	1	4	8
1395	R:R:G316	R:R:G532	15.4617	2.11	No	No	1	8	1
1396	S:S:I162	S:S:N118	41.3728	4.25	Yes	No	2	6	4
1397	R:R:G273	R:R:S272	25.7857	1.86	No	No	0	4	5
1398	R:R:Q164	R:R:V153	27.0248	4.3	Yes	Yes	1	8	6
1399	R:R:T145	W:W:W1	41.2678	6.06	Yes	Yes	1	5	0
1400	R:R:R66	W:W:W1	100	4	Yes	Yes	1	5	0
1401	R:R:I416	W:W:W1	46.4664	5.87	Yes	Yes	1	4	0
1402	R:R:A168	W:W:W1	15.4831	5.19	No	Yes	1	5	0
1403	R:R:D484	R:R:N189	16.5012	4.04	Yes	No	1	8	8
1404	R:R:E297	W:W:W1	100	5.45	No	Yes	0	8	0
1405	R:R:V513	R:R:Y514	100	7.57	Yes	Yes	1	3	4
1406	S:S:I75	S:S:L71	30.9397	2.85	Yes	Yes	2	4	4
1407	S:S:F38	S:S:L71	100	7.31	Yes	Yes	2	7	4
1408	S:S:I139	S:S:I32	100	5.89	Yes	Yes	11	5	6
1409	S:S:G35	S:S:V141	62.4129	5.52	Yes	No	2	8	7
1410	S:S:R69	S:S:Y408	100	3.09	Yes	Yes	2	8	3
1411	S:S:F65	S:S:P407	100	7.22	Yes	Yes	2	2	1
1412	S:S:E350	S:S:E354	10.3109	2.54	Yes	No	2	5	4
1413	S:S:E354	S:S:F65	20.624	2.33	No	Yes	2	4	2
1414	R:R:F160	R:R:I162	13.393	2.51	Yes	Yes	1	7	6
1415	S:S:L334	S:S:Y408	10.3399	11.72	Yes	Yes	2	6	3
1416	S:S:I416	S:S:W70	51.5764	12.92	Yes	Yes	2	4	5
1417	S:S:L87	S:S:Y425	92.8066	4.69	Yes	Yes	2	6	8
1418	S:S:A140	S:S:I427	41.5003	4.87	No	Yes	0	6	5
1419	S:S:I427	S:S:L464	41.5099	4.28	Yes	Yes	0	5	7
1420	S:S:L174	S:S:S169	41.2313	3	Yes	Yes	2	7	8
1421	S:S:S166	S:S:S169	20.614	6.52	Yes	Yes	2	9	8
1422	S:S:Q459	S:S:W458	41.2484	16.43	Yes	Yes	11	7	4
1423	S:S:L184	S:S:V165	20.7598	2.98	No	Yes	2	6	6
1424	S:S:A423	S:S:T186	30.92	3.36	No	No	2	9	8
1425	S:S:S426	S:S:V165	20.8494	3.23	Yes	Yes	2	7	6
1426	S:S:I187	S:S:S170	100	4.64	Yes	Yes	2	6	7
1427	S:S:L174	S:S:R185	82.4815	4.86	Yes	Yes	2	7	9
1428	S:S:F270	S:S:I223	66.0095	8.79	Yes	Yes	2	7	5
1429	S:S:F270	S:S:G222	100	4.52	Yes	No	0	7	7
1430	R:R:D215	R:R:R220	21.7004	7.15	Yes	Yes	2	6	6
1431	S:S:D190	S:S:E297	10.3607	3.9	Yes	Yes	2	8	8
1432	S:S:A198	S:S:F226	16.5071	2.77	No	Yes	0	7	6
1433	S:S:I200	S:S:L521	18.6273	4.28	Yes	Yes	0	8	5
1434	S:S:I237	S:S:V209	100	3.07	No	Yes	2	6	8
1435	S:S:I201	S:S:V209	100	3.07	Yes	Yes	2	6	8
1436	S:S:F204	S:S:Y203	12.4232	7.22	Yes	No	2	7	5
1437	S:S:F204	S:S:I523	12.4232	5.02	Yes	No	2	7	6
1438	S:S:F539	S:S:K265	66.0633	2.48	Yes	No	0	1	5
1439	S:S:F239	S:S:G210	100	7.53	Yes	No	0	6	8
1440	S:S:F330	S:S:L414	41.2479	6.09	Yes	Yes	2	8	6
1441	S:S:F469	S:S:Y425	82.6102	2.06	Yes	Yes	2	8	8
1442	S:S:F444	S:S:Q459	20.659	4.68	Yes	Yes	11	3	7
1443	R:R:W70	R:R:Y167	10.3216	3.86	Yes	Yes	1	5	8
1444	R:R:V420	R:R:W70	10.3226	2.45	Yes	Yes	1	7	5
1445	R:R:P39	R:R:T145	10.3214	8.74	Yes	Yes	1	6	5
1446	R:R:F351	R:R:Y63	25.8253	6.19	Yes	Yes	1	6	5
1447	R:R:F351	R:R:Y408	100	11.35	Yes	Yes	1	6	3
1448	R:R:R66	W:W:?2	30.958	26.55	Yes	Yes	1	5	0
1449	R:R:I416	W:W:?2	43.3897	9.85	Yes	Yes	1	4	0
1450	R:R:F330	R:R:R69	36.2975	2.14	Yes	Yes	1	8	8
1451	R:R:L414	R:R:R69	20.7286	2.43	Yes	Yes	1	6	8
1452	R:R:E80	R:R:F76	10.4475	5.83	No	Yes	1	8	7
1453	R:R:F330	R:R:F76	20.8209	6.43	Yes	Yes	1	8	7
1454	R:R:F180	R:R:L174	76.3861	3.65	Yes	Yes	1	5	7
1455	H:H:?11	R:R:Y514	100	14.64	Yes	Yes	1	0	4
1456	R:R:L422	R:R:Y418	49.5481	7.03	No	Yes	1	8	7
1457	R:R:N512	R:R:Y510	30.9699	2.33	Yes	No	1	4	3
1458	S:S:F351	S:S:F65	100	4.29	Yes	Yes	2	6	2
1459	S:S:T355	S:S:T406	82.4996	3.14	Yes	No	2	4	4
1460	S:S:R66	X:X:W1	100	3	Yes	Yes	2	5	0
1461	S:S:F351	S:S:Y408	100	19.6	Yes	Yes	2	6	3
1462	S:S:R66	X:X:?2	92.7962	18.17	Yes	Yes	2	5	0
1463	S:S:T436	S:S:Y435	20.6568	4.99	No	No	0	4	3
1464	S:S:L88	S:S:Q432	41.2416	2.66	No	No	0	9	7
1465	S:S:F183	S:S:S150	10.311	5.28	Yes	Yes	2	8	8
1466	S:S:D275	S:S:Q245	25.8118	5.22	Yes	Yes	0	5	4
1467	S:S:I401	S:S:I409	10.3215	4.42	Yes	Yes	2	7	5
1468	R:R:E350	R:R:Y63	15.4857	8.98	Yes	Yes	1	5	5
1469	R:R:F68	R:R:I40	15.5478	2.51	Yes	Yes	1	7	5
1470	R:R:H41	R:R:Y63	31.0392	5.44	Yes	Yes	1	7	5
1471	R:R:Y418	R:R:Y421	37.1616	1.99	Yes	Yes	1	7	8
1472	R:R:L174	R:R:R185	78.6175	4.86	Yes	Yes	1	7	9
1473	S:S:H41	S:S:Y63	100	5.44	Yes	Yes	2	7	5
1474	S:S:F505	S:S:W494	20.6497	12.03	No	Yes	8	4	7
1475	S:S:I327	S:S:L414	100	2.85	Yes	Yes	2	6	6
1476	S:S:E79	S:S:F76	30.9298	4.66	No	Yes	2	7	7
1477	S:S:K335	S:S:R331	41.2567	12.38	No	Yes	2	4	4
1478	S:S:L431	S:S:V455	61.8485	2.98	No	Yes	11	8	4
1479	S:S:S170	S:S:Y218	61.9192	2.54	Yes	Yes	2	7	7
1480	S:S:S147	S:S:Y218	100	2.54	No	Yes	2	8	7
1481	S:S:V513	S:S:Y511	52.7212	2.52	Yes	Yes	2	3	5
1482	S:S:W206	S:S:W530	100	5.62	Yes	Yes	2	9	8
1483	S:S:I318	S:S:W530	100	3.52	No	Yes	0	6	8
1484	S:S:F226	S:S:T211	33	2.59	Yes	Yes	2	6	5
1485	S:S:I292	S:S:P538	16.5003	5.08	Yes	No	2	7	8
1486	S:S:P538	S:S:V537	16.4996	3.53	No	Yes	2	8	4
1487	S:S:E399	S:S:F356	41.2503	15.16	No	Yes	2	8	8
1488	S:S:I401	S:S:T355	10.313	4.56	Yes	Yes	2	7	4
1489	S:S:V420	S:S:W70	61.8722	2.45	Yes	Yes	2	7	5
1490	R:R:F38	R:R:I97	30.9581	2.51	Yes	Yes	1	7	8
1491	R:R:F38	R:R:M74	20.6417	7.46	Yes	Yes	1	7	8
1492	H:H:?5	S:S:E257	72.1684	3.55	No	No	0	0	3
1493	R:R:I237	R:R:V209	26.8011	3.07	Yes	Yes	1	6	8
1494	S:S:E525	S:S:W530	32.998	8.72	Yes	Yes	2	4	8
1495	S:S:L304	S:S:P274	72.3053	3.28	No	Yes	8	2	3
1496	S:S:D217	S:S:G148	10.3116	3.35	Yes	No	2	6	4
1497	S:S:E241	S:S:V258	36.0932	9.98	No	No	2	5	4
1498	S:S:A298	S:S:Y218	10.3088	4	No	Yes	2	6	7
1499	R:R:F114	R:R:G35	100	4.52	Yes	Yes	1	5	8
1500	R:R:L322	R:R:N419	100	4.12	Yes	Yes	1	4	7
1501	R:R:I200	R:R:L521	100	2.85	Yes	Yes	1	8	5
1502	R:R:F204	R:R:Y203	100	9.28	Yes	No	1	7	5
1503	R:R:E475	R:R:M473	24.8122	2.71	Yes	Yes	1	5	4
1504	R:R:H429	R:R:L87	100	10.29	No	No	0	6	6
1505	S:S:E257	S:S:Q253	36.0822	2.55	No	No	38	3	3
1506	R:R:V313	R:R:V314	20.6087	3.21	Yes	Yes	1	3	7
1507	R:R:T211	R:R:V268	10.3056	3.17	Yes	Yes	1	5	6
1508	R:R:F204	R:R:I523	100	3.77	Yes	Yes	1	7	6
1509	R:R:F239	R:R:I259	10.3025	3.77	Yes	Yes	1	6	6
1510	R:R:T317	R:R:W293	10.3032	7.28	No	Yes	1	7	8
1511	S:S:S591	S:S:W590	21.0898	2.47	Yes	Yes	10	8	6
1512	S:S:F684	S:S:I841	57.7292	15.07	Yes	Yes	12	8	9
1513	S:S:E837	S:S:F668	12.0496	10.49	Yes	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:F38	S:S:W70	3.01	2	Yes	Yes	7	5	2	1
S:S:F38	S:S:Y167	12.38	2	Yes	Yes	7	8	2	2
S:S:F38	S:S:V420	3.93	2	Yes	Yes	7	7	2	2
S:S:G67	S:S:P39	2.03	2	No	Yes	4	6	2	2
S:S:P39	S:S:W70	5.4	2	Yes	Yes	6	5	2	1
S:S:P39	S:S:T145	8.74	2	Yes	Yes	6	5	2	1
S:S:N64	S:S:R66	6.03	0	No	Yes	4	5	2	1
S:S:G67	S:S:N64	3.39	2	No	No	4	4	2	2
S:S:R66	S:S:R69	3.2	2	Yes	Yes	5	8	1	2
S:S:R66	S:S:W70	8	2	Yes	Yes	5	5	1	1
S:S:P407	S:S:R66	2.88	2	Yes	Yes	1	5	2	1
S:S:R66	X:X:W1	3	2	Yes	Yes	5	0	1	0
S:S:R66	X:X:?2	18.17	2	Yes	Yes	5	0	1	2
S:S:G67	S:S:W70	5.63	2	No	Yes	4	5	2	1
S:S:R69	X:X:?2	5.59	2	Yes	Yes	8	0	2	2
S:S:T145	S:S:W70	7.28	2	Yes	Yes	5	5	1	1
S:S:W70	S:S:Y167	5.79	2	Yes	Yes	5	8	1	2
S:S:I416	S:S:W70	12.92	2	Yes	Yes	4	5	2	1
S:S:S417	S:S:W70	6.18	2	No	Yes	6	5	2	1
S:S:V420	S:S:W70	2.45	2	Yes	Yes	7	5	2	1
S:S:W70	X:X:W1	2.81	2	Yes	Yes	5	0	1	0
S:S:W70	X:X:?2	9.17	2	Yes	Yes	5	0	1	2
S:S:G146	S:S:T145	3.64	2	No	Yes	5	5	1	1
S:S:T145	S:S:Y167	6.24	2	Yes	Yes	5	8	1	2
S:S:A168	S:S:T145	5.03	2	No	Yes	5	5	1	1
S:S:T145	X:X:W1	4.85	2	Yes	Yes	5	0	1	0
S:S:G146	S:S:V149	3.68	2	No	No	5	4	1	2
S:S:G146	X:X:W1	4.22	2	No	Yes	5	0	1	0
S:S:S147	S:S:S171	6.52	2	No	No	8	7	1	2
S:S:S147	S:S:Y218	2.54	2	No	Yes	8	7	1	1
S:S:S147	X:X:W1	6.18	2	No	Yes	8	0	1	0
S:S:A168	S:S:Y167	2.67	2	No	Yes	5	8	1	2
S:S:I416	S:S:Y167	4.84	2	Yes	Yes	4	8	2	2
S:S:V420	S:S:Y167	10.09	2	Yes	Yes	7	8	2	2
S:S:A168	X:X:W1	3.89	2	No	Yes	5	0	1	0
S:S:I187	S:S:S170	4.64	2	Yes	Yes	6	7	2	1
S:S:D190	S:S:S170	10.31	2	Yes	Yes	8	7	2	1
S:S:S170	S:S:Y218	2.54	2	Yes	Yes	7	7	1	1
S:S:S170	X:X:W1	4.94	2	Yes	Yes	7	0	1	0
S:S:D190	S:S:Y218	5.75	2	Yes	Yes	8	7	2	1
S:S:D216	S:S:Y218	3.45	0	No	Yes	6	7	2	1
S:S:G219	S:S:Y218	2.9	0	No	Yes	7	7	2	1
S:S:S296	S:S:Y218	6.36	0	No	Yes	8	7	2	1
S:S:A298	S:S:Y218	4	2	No	Yes	6	7	1	1
S:S:Y218	X:X:W1	15.43	2	Yes	Yes	7	0	1	0
S:S:A298	X:X:W1	6.48	2	No	Yes	6	0	1	0
S:S:I416	X:X:?2	6.57	2	Yes	Yes	4	0	2	2
S:S:S417	X:X:?2	5.18	2	No	Yes	6	0	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
100.00	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
100.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
100.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
100.00	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
100.00	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
100.00	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
100.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
100.00	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
100.00	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
100.00	Single	7DD5	Ca3	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
100.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
100.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
100.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
100.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
100.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00	Single	7EB2	Baclofen	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
100.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
100.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
100.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
100.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
100.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
100.00	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00	Single	7FII	hCG	7FII-LH-hCG-6fuf
100.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
100.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
100.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
100.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
100.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
100.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
100.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
100.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
100.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
100.00	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
100.00	Single	7XW7	K1-70	7XW7-TSH-K1-70
100.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
100.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
100.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
100.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
100.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
100.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
100.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
100.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
100.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
100.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
100.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
100.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
100.00	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-J9R
100.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
100.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
100.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
100.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
100.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
100.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
100.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
100.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
100.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
100.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
100.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
100.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
100.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
100.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
100.00	Consensus	fsh_on_allo	Orthosteric Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
100.00	Consensus	gabab_off	Orthosteric Ligand	7C7S-GABA_B1, GABA_B2-CGP54626 7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid 6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
100.00	Consensus	gabab_on	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
100.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
100.00	Consensus	gi_gaba	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	gphr_on	Orthosteric Ligand	lh_on tsh_on
100.00	Consensus	gs_gphr	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00	Consensus	gs_protein	Orthosteric Ligand	gs_gphr
100.00	Consensus	lh_on	Orthosteric Ligand	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00	Consensus	lh_on_allo	Orthosteric Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
100.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
100.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
100.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
100.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
100.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
100.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
100.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
100.00	Consensus	smo_off_allo	Other Ligand	6D32-SMO-Cyclopamine-Cyclopamine
100.00	Consensus	tsh_on	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2
100.00	Consensus	tsh_on_allo	Orthosteric Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
50.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
33.33	Single	8HS2	Fab046	8HS2-GPR20-Fab046
25.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
25.00	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00	Single	7UTZ	TR1402	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
25.00	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
25.00	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
20.00	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
20.00	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/&β;1/&γ;2
20.00	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
20.00	Single	8I2G	Glycoprotein hormones alpha chain	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
14.29	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
14.29	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
14.29	Single	6LI0	GTPL9804	6LI0-GPR52-GTPL9804
14.29	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
14.29	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
14.29	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
12.50	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
12.50	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
12.50	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
12.50	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50	Consensus	go_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.50	Consensus	go_protein	Orthosteric Ligand	go_chemokine
12.50	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
11.11	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
11.11	Single	5U09	Taranabant	5U09-CB₁-Taranabant
11.11	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.11	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
11.11	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
11.11	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
11.11	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
11.11	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
11.11	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
11.11	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
11.11	Single	8HMP	PubChem 69921479	8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Consensus	class-f_off	Orthosteric Ligand	smo_off
11.11	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
11.11	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
11.11	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
10.00	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
10.00	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
10.00	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.00	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
10.00	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
10.00	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
10.00	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
10.00	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
10.00	Consensus	gi_class-f	Orthosteric Ligand	gi_frizzled
10.00	Consensus	gi_frizzled	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
10.00	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
10.00	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
9.09	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
9.09	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
9.09	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
9.09	Single	6D27	CAY10471	6D27-DP₂-CAY10471
9.09	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.09	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
9.09	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
9.09	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
9.09	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
9.09	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
9.09	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
9.09	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
9.09	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
9.09	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.09	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
9.09	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
9.09	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.33	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
8.33	Single	5C1M	BU72	5C1M-μ-BU72
8.33	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.33	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.33	Single	7C4S	S1P	7C4S-S1P₃-S1P
8.33	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
8.33	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
8.33	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.33	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
8.33	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
8.33	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
8.33	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.69	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
7.69	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
7.69	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
7.69	Single	5V56	TC114	5V56-SMO-TC114
7.69	Single	5V57	TC114	5V57-SMO-TC114
7.69	Single	6OS1	TRV026	6OS1-AT₁-TRV026
7.69	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
7.69	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.69	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
7.69	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
7.69	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.69	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.69	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.69	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
7.69	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
7.69	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
7.69	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Single	8E0G	BU72	8E0G-μ-BU72
7.69	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
7.69	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
7.69	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.69	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
7.69	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
7.69	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
7.69	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.69	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
7.14	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
7.14	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
7.14	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
7.14	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
7.14	Single	6OS2	TRV026	6OS2-AT₁-TRV026
7.14	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.14	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
7.14	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
7.14	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.14	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
7.14	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
7.14	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.14	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
7.14	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
7.14	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
7.14	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
7.14	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
7.14	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
7.14	Consensus	dp_off	Orthosteric Ligand	dp2_off
7.14	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
7.14	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
7.14	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.14	Consensus	nts_on	Orthosteric Ligand	nts1_on
7.14	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
7.14	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.67	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
6.67	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
6.67	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
6.67	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
6.67	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
6.67	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
6.67	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6.67	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
6.67	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
6.67	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
6.67	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.67	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.67	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
6.25	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
6.25	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
6.25	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
6.25	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
6.25	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
6.25	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
6.25	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
6.25	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
6.25	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
6.25	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
6.25	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
6.25	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
5.88	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
5.88	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.88	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.88	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
5.88	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
5.88	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
5.88	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.88	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
5.88	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.88	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.88	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.88	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
5.88	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.88	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.88	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.88	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
5.88	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
5.56	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
5.56	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.56	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
5.56	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
5.56	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
5.56	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
5.56	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
5.56	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.56	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
5.56	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.56	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.56	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
5.56	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
5.26	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
5.26	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
5.26	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
5.26	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
5.26	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
5.26	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.26	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
5.26	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
5.26	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.26	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
5.26	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
5.26	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
5.26	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
5.26	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
5.00	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
5.00	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
5.00	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
5.00	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
5.00	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.00	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
5.00	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
5.00	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
5.00	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
5.00	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
5.00	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
5.00	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
5.00	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
5.00	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.00	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
5.00	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
5.00	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.76	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.76	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
4.76	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.76	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.76	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.76	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.76	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.76	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.76	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.76	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.76	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
4.76	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
4.76	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.76	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
4.76	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
4.55	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
4.55	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
4.55	Single	6FJ3	PTH	6FJ3-PTH1-PTH
4.55	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.55	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.55	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
4.55	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
4.55	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
4.55	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.55	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
4.55	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
4.55	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.55	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.55	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
4.55	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.55	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.35	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
4.35	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
4.35	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
4.35	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.35	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
4.35	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
4.35	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
4.35	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.35	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.35	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.35	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
4.35	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.35	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
4.35	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
4.35	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.35	Consensus	go_class-b1	Orthosteric Ligand	go_crf
4.35	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.35	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.17	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
4.17	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
4.17	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.17	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
4.17	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.17	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
4.17	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.17	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
4.17	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
4.17	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
4.17	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
4.17	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
4.17	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
4.17	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.17	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.17	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.17	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
4.17	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
4.17	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
4.17	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.00	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
4.00	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.00	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
4.00	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
4.00	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.00	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
4.00	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.00	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
4.00	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
4.00	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.00	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
4.00	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.00	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
3.85	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.85	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
3.85	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.85	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.85	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.85	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.85	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
3.85	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
3.70	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
3.70	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.70	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.70	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.70	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.70	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
3.57	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.57	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.57	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.57	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.57	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.57	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.57	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.57	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.57	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
3.57	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.45	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.45	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.45	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
3.45	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
3.33	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.33	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.23	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.23	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
3.23	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.12	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
3.12	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
3.12	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.03	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
3.03	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
3.03	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.94	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.94	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.86	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:C661	S:S:F684	2.79	0	No	Yes	7	8	2	1
S:S:F684	S:S:S664	5.28	12	Yes	No	8	6	1	2
S:S:F668	S:S:R680	13.9	0	Yes	Yes	9	8	2	2
S:S:E837	S:S:F668	10.49	12	Yes	Yes	9	9	1	2
S:S:F668	S:S:I841	3.77	0	Yes	Yes	9	9	2	1
S:S:Q681	S:S:R680	7.01	0	No	Yes	9	8	1	2
S:S:L773	S:S:Q681	5.32	0	No	No	8	9	2	1
S:S:Q681	X:X:?4	7.94	0	No	Yes	9	0	1	0
S:S:F684	S:S:F688	10.72	12	Yes	Yes	8	8	1	2
S:S:F684	S:S:W818	6.01	12	Yes	Yes	8	9	1	1
S:S:F684	S:S:I841	15.07	12	Yes	Yes	8	9	1	1
S:S:F684	X:X:?4	19.98	12	Yes	Yes	8	0	1	0
S:S:G685	S:S:Q735	4.93	0	No	Yes	8	9	1	2
S:S:G685	X:X:?4	2.55	0	No	Yes	8	0	1	0
S:S:F688	S:S:F814	7.5	0	Yes	Yes	8	9	2	2
S:S:A844	S:S:F688	2.77	0	No	Yes	9	8	2	2
S:S:Q735	S:S:V689	17.19	46	Yes	Yes	9	7	2	2
S:S:T780	S:S:V689	3.17	0	No	Yes	7	7	1	2
S:S:E767	S:S:W742	3.27	12	Yes	Yes	7	9	1	2
S:S:E767	S:S:H766	2.46	12	Yes	Yes	7	6	1	2
S:S:E767	S:S:L770	7.95	12	Yes	No	7	3	1	1
S:S:E767	S:S:L773	2.65	12	Yes	No	7	8	1	2
S:S:E767	X:X:?4	1.98	12	Yes	Yes	7	0	1	0
S:S:L770	X:X:?4	6.19	12	No	Yes	3	0	1	0
S:S:I777	X:X:?4	19.15	0	No	Yes	8	0	1	0
S:S:T780	X:X:?4	6.59	0	No	Yes	7	0	1	0
S:S:F814	S:S:W818	7.02	12	Yes	Yes	9	9	2	1
S:S:F821	S:S:W818	12.03	12	Yes	Yes	9	9	1	1
S:S:A840	S:S:W818	7.78	12	No	Yes	9	9	2	1
S:S:I841	S:S:W818	2.35	12	Yes	Yes	9	9	1	1
S:S:A844	S:S:W818	2.59	0	No	Yes	9	9	2	1
S:S:W818	X:X:?4	18.68	12	Yes	Yes	9	0	1	0
S:S:F821	S:S:Y825	11.35	12	Yes	Yes	9	9	1	1
S:S:F821	S:S:V836	3.93	12	Yes	No	9	8	1	2
S:S:E837	S:S:F821	2.33	12	Yes	Yes	9	9	1	1
S:S:A840	S:S:F821	4.16	12	No	Yes	9	9	2	1
S:S:F821	X:X:?4	1.82	12	Yes	Yes	9	0	1	0
S:S:V833	S:S:Y825	5.05	0	No	Yes	6	9	2	1
S:S:V836	S:S:Y825	2.52	12	No	Yes	8	9	2	1
S:S:E837	S:S:Y825	5.61	12	Yes	Yes	9	9	1	1
S:S:Y825	X:X:?4	10.49	12	Yes	Yes	9	0	1	0
S:S:E837	X:X:?4	6.91	12	Yes	Yes	9	0	1	0
S:S:I841	X:X:?4	2.13	12	Yes	Yes	9	0	1	0
S:S:C781	S:S:I777	1.64	0	No	No	7	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
84.62	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
78.57	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
78.57	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
71.43	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
71.43	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
71.43	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
69.23	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
61.54	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
61.54	Single	7EJ0	L-Norepinephrine	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2
61.54	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
61.54	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
61.54	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
60.00	Single	6PS6	Timolol	6PS6-β₂-Timolol
60.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
57.14	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
56.25	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
56.25	Consensus	5ht_off	Orthosteric Ligand	5ht2_off 5ht5_off 5ht1_off
53.85	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
53.85	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
53.85	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
53.33	Single	3NY8	ICI 118-551	3NY8-β₂-ICI 118-551
53.33	Single	3NYA	(S)-Alprenolol	3NYA-β₂-(S)-Alprenolol
53.33	Single	3ZPR	4-methyl-2-(piperazin-1-yl)	3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
53.33	Single	4GBR	(S)-Carazolol	4GBR-β₂-(S)-Carazolol
53.33	Single	5JQH	(S)-Carazolol	5JQH-β₂-(S)-Carazolol
53.33	Single	6PS0	(S)-Carazolol	6PS0-β₂-(S)-Carazolol
53.33	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
53.33	Single	8JJO	Alprenolol	8JJO-β₂-Alprenolol
53.33	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
50.00	Single	2RH1	(S)-Carazolol	2RH1-β₂-(S)-Carazolol
50.00	Single	2YCW	(S)-Carazolol	2YCW-β₁-(S)-Carazolol
50.00	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
50.00	Single	5D6L	(S)-Carazolol	5D6L-β₂-(S)-Carazolol
50.00	Single	5X7D	(S)-Carazolol	5X7D-β₂-(S)-Carazolol-PubChem 129318963
50.00	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
50.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
50.00	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
50.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
50.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
50.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
50.00	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
50.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
50.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
50.00	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2
50.00	Single	8UO0	Epinephrine	8UO0-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
50.00	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
50.00	Consensus	alpha2_off	Orthosteric Ligand	alpha2a_off alpha2c_off
50.00	Consensus	amine_off	Orthosteric Ligand	adrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
50.00	Consensus	beta1_off_allo	Orthosteric Ligand	4BVN-β₁-Cyanopindolol-Na
50.00	Consensus	beta2_off	Orthosteric Ligand	6PS2-β₂-(S)-Alprenolol 6PS3-β₂-(S)-Carvedilol 6PS5-β₂-(S)-Propranolol 6PS6-β₂-Timolol 2RH1-β₂-(S)-Carazolol 6PS4-β₂-ICI 118-551 3NY9-β₂-PubChem 913103
50.00	Consensus	beta_off	Orthosteric Ligand	beta1_off beta2_off
50.00	Consensus	gi_nucleotide	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
47.37	Single	3NY9	PubChem 913103	3NY9-β₂-PubChem 913103
47.06	Single	2YDV	NECA	2YDV-A_2A-NECA
47.06	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
47.06	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
47.06	Single	5D5A	(S)-Carazolol	5D5A-β₂-(S)-Carazolol
47.06	Single	5D5B	(S)-Carazolol	5D5B-β₂-(S)-Carazolol
47.06	Single	5G53	NECA	5G53-A_2A-NECA-Gs
47.06	Single	5X93	K-8794	5X93-ET_B-K-8794
47.06	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
47.06	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
47.06	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
47.06	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
47.06	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
47.06	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
47.06	Single	7EW7	PubChem 4077460	7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
47.06	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2
47.06	Single	7U2L	PubChem 163201242	7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
47.06	Single	7W6P	W96	7W6P-α_2a-W96-Go/&β;1/&γ;2
47.06	Single	7W7E	W58	7W7E-α_2a-W58-Go/&β;1/&γ;2
47.06	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/&β;1/&γ;2
47.06	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2
47.06	Single	8IRU	Rotigotine	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
47.06	Consensus	beta1_off	Orthosteric Ligand	2VT4-β₁-Cyanopindolol 2YCZ-β₁-Iodocyanopindolol
47.06	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
47.06	Consensus	dopamine_off	Orthosteric Ligand	d3_off d2_off d4_off
47.06	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
47.06	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2
46.67	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
46.67	Single	3UZC	PubChem 135566609	3UZC-A_2A-PubChem 135566609
46.67	Single	4LDO	L-Epinephrine	4LDO-β₂-L-Epinephrine
46.67	Single	6K41	Dexmedetomidine	6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2
46.67	Single	6PS4	ICI 118-551	6PS4-β₂-ICI 118-551
46.67	Single	6V9S	GTPL11403	6V9S-OX₁-GTPL11403
46.67	Single	8GEG	Epinephrine	8GEG-β₂-Epinephrine-Gs/&β;1/&γ;2
46.67	Single	8GGQ	Epinephrine	8GGQ-β₂-Epinephrine
46.67	Single	8JLN	T1AM	8JLN-TA1-T1AM-Gs/&β;1/&γ;2
46.67	Single	8THL	Epinephrine	8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67	Single	8UNZ	Epinephrine	8UNZ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67	Single	8UO2	Epinephrine	8UO2-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2
46.67	Consensus	alpha2b_on	Orthosteric Ligand	6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2
46.15	Single	3C9M	11-cis-Retinal	3C9M-Rhodopsin-11-cis-Retinal
46.15	Single	8IU2	Retinal	8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
44.44	Single	3D4S	Timolol Maleate	3D4S-β₂-Timolol Maleate
44.44	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
44.44	Single	4LDE	BI167107	4LDE-β₂-BI167107
44.44	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
44.44	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
44.44	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
44.44	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
44.44	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
44.44	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
44.44	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
44.44	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/&β;1/&γ;2
44.44	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.44	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
44.44	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.44	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
44.44	Consensus	gpr119_on	Orthosteric Ligand	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
44.44	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
44.44	Consensus	leuko_off	Orthosteric Ligand	blt_off cyslt_off
44.44	Consensus	opioid_off	Orthosteric Ligand	kop_off mop_off nop_off dop_off
43.75	Single	2VT4	Cyanopindolol	2VT4-β₁-Cyanopindolol
43.75	Single	2Y04	Salbutamol	2Y04-β₁-Salbutamol
43.75	Single	2YCY	Cyanopindolol	2YCY-β₁-Cyanopindolol
43.75	Single	3ZPQ	4-(piperazin-1- yl)-1H-indole	3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na
43.75	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
43.75	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
43.75	Single	4U16	N-Methyl Scopolamine	4U16-M₃-N-Methyl Scopolamine
43.75	Single	4X1H	Nonyl Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
43.75	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
43.75	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
43.75	Single	6K42	Dexmedetomidine	6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
43.75	Single	6PRZ	(S)-Alprenolol	6PRZ-β₂-(S)-Alprenolol
43.75	Single	6PS1	Timolol	6PS1-β₂-Timolol
43.75	Single	6PS2	(S)-Alprenolol	6PS2-β₂-(S)-Alprenolol
43.75	Single	7BTS	L-Epinephrine	7BTS-β₁-L-Epinephrine
43.75	Single	7BU6	L-Norepinephrine	7BU6-β₁-L-Norepinephrine
43.75	Single	7BU7	BI167107	7BU7-β₁-BI167107
43.75	Single	7E32	Serotonin	7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2
43.75	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
43.75	Single	7S0G	Isoprenaline	7S0G-β₁-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
43.75	Single	7UL4	Alvimopan	7UL4-μ-Alvimopan
43.75	Single	7UM5	5-CT	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
43.75	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
43.75	Single	8CIC	Etrumadenant	8CIC-A_2A-Etrumadenant-Na
43.75	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
43.75	Single	8GE3	Epinephrine	8GE3-β₂-Epinephrine-Gs/&β;1/&γ;2
43.75	Single	8GEE	Epinephrine	8GEE-β₂-Epinephrine-Gs/&β;1/&γ;2
43.75	Single	8GEH	Epinephrine	8GEH-β₂-Epinephrine-Gs/&β;1/&γ;2
43.75	Single	8GFW	Epinephrine	8GFW-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75	Single	8GFX	Epinephrine	8GFX-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75	Single	8GFY	Epinephrine	8GFY-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75	Single	8GFZ	Epinephrine	8GFZ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75	Single	8GG0	Epinephrine	8GG0-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75	Single	8GG1	Epinephrine	8GG1-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75	Single	8GG2	Epinephrine	8GG2-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75	Single	8GG6	Epinephrine	8GG6-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75	Single	8GGJ	Epinephrine	8GGJ-β₂-Epinephrine
43.75	Single	8GGN	Epinephrine	8GGN-β₂-Epinephrine
43.75	Single	8GGO	Epinephrine	8GGO-β₂-Epinephrine
43.75	Single	8GGU	Epinephrine	8GGU-β₂-Epinephrine
43.75	Single	8UNN	Epinephrine	8UNN-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75	Single	8UNP	Epinephrine	8UNP-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75	Single	8UO4	Epinephrine	8UO4-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
43.75	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
43.75	Consensus	5ht1d_on	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2
43.75	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
43.75	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on
43.75	Consensus	adrenergic_on	Orthosteric Ligand	beta_on alpha_on
43.75	Consensus	alpha2_on	Orthosteric Ligand	alpha2a_on alpha2b_on
43.75	Consensus	alpha_on	Orthosteric Ligand	alpha1_on alpha2_on
43.75	Consensus	amine_on	Orthosteric Ligand	adrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
43.75	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
43.75	Consensus	dopamine_on	Orthosteric Ligand	d3_on d2_on d5_on d1_on
43.75	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on
42.86	Single	1L9H	11-cis-Retinal	1L9H-Rhodopsin-11-cis-Retinal
42.86	Single	1U19	11-cis-Retinal	1U19-Rhodopsin-11-cis-Retinal
42.86	Single	2G87	All-trans-retinal	2G87-Rhodopsin-All-trans-retinal
42.86	Single	2I35	11-cis-Retinal	2I35-Rhodopsin-11-cis-Retinal
42.86	Single	3AYM	All-trans-retinal	3AYM-Rhodopsin-All-trans-retinal
42.86	Single	3PBL	Eticlopride	3PBL-D₃-Eticlopride
42.86	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
42.86	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
42.86	Single	7EJK	Oxymetazoline	7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2
42.86	Single	8GEI	Epinephrine	8GEI-β₂-Epinephrine-Gs/&β;1/&γ;2
42.86	Single	8ITF	DMCHA	8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
42.86	Single	8WC3	SEP-363856	8WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
42.86	Consensus	d3_off	Orthosteric Ligand	3PBL-D₃-Eticlopride
42.86	Consensus	ox1_off_allo	Orthosteric Ligand	6TOD-OX₁-EMPA-Na 6TOS-OX₁-GSK1059865-Na 6TQ4-OX₁-PubChem 16046844-Na 6TO7-OX₁-Suvorexant-Na
42.11	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
42.11	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
42.11	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
42.11	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
42.11	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
42.11	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
42.11	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
42.11	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
42.11	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
42.11	Consensus	endothelin_off	Orthosteric Ligand	etb_off
42.11	Consensus	etb_off	Orthosteric Ligand	5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500 5X93-ET_B-K-8794
42.11	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
41.67	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
41.18	Single	2Y03	Isoprenaline	2Y03-β₁-Isoprenaline
41.18	Single	5N2R	PubChem 92460631; psb36	5N2R-A_2A-PubChem 92460631; psb36-Na
41.18	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
41.18	Single	5TVN	LSD	5TVN-5-HT_2B-LSD
41.18	Single	5XPR	Bosentan	5XPR-ET_B-Bosentan
41.18	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
41.18	Single	6PS3	(S)-Carvedilol	6PS3-β₂-(S)-Carvedilol
41.18	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
41.18	Single	7BVQ	(S)-Carazolol	7BVQ-β₁-(S)-Carazolol
41.18	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
41.18	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2
41.18	Single	7XKA	Epinephrine	7XKA-β₂-Epinephrine
41.18	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
41.18	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/&β;1/&γ;2
41.18	Single	8DZR	GR89,696	8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
41.18	Single	8E9Z	Iperoxo	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18	Single	8EFB	Oliceridine	8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
41.18	Single	8UNY	Epinephrine	8UNY-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18	Consensus	5ht1_on	Orthosteric Ligand	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
41.18	Consensus	a1_on_allo	Orthosteric Ligand	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
41.18	Consensus	adrenergic_off	Orthosteric Ligand	beta_off alpha_off
41.18	Consensus	alpha2a_on	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
41.18	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
41.18	Consensus	beta2_on	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2
41.18	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
41.18	Consensus	gi_adrenergic	Orthosteric Ligand	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
41.18	Consensus	go_amine	Orthosteric Ligand	go_adrenergic go_muscarinic go_5ht
41.18	Consensus	go_opioid	Orthosteric Ligand	8DZQ-κ-momSalB-Go/&β;1/&γ;2
41.18	Consensus	gq_muscarinic	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
41.18	Consensus	m1_on	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
41.18	Consensus	m2_off	Orthosteric Ligand	5ZKB-M₂-AF-DX 384 5ZKC-M₂-N-Methyl Scopolamine 5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
41.18	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
40.91	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
40.00	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
40.00	Single	1GZM	11-cis-Retinal	1GZM-Rhodopsin-11-cis-Retinal
40.00	Single	2PED	9-cis-Retinal	2PED-Rhodopsin-9-cis-Retinal
40.00	Single	2X72	All-trans-retinal	2X72-Rhodopsin-All-trans-retinal-Gt(CT)
40.00	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
40.00	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
40.00	Single	3C9L	11-cis-Retinal	3C9L-Rhodopsin-11-cis-Retinal
40.00	Single	4S0V	Suvorexant	4S0V-OX₂-Suvorexant
40.00	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
40.00	Single	5WS3	EMPA	5WS3-OX₂-EMPA
40.00	Single	6B73	PubChem 131955138	6B73-κ-PubChem 131955138
40.00	Single	6KUX	RS-79948	6KUX-α_2a-RS-79948
40.00	Single	6KUY	PubChem 145704643	6KUY-α_2a-PubChem 145704643
40.00	Single	6TOD	EMPA	6TOD-OX₁-EMPA-Na
40.00	Single	6TPJ	Suvorexant	6TPJ-OX₂-Suvorexant
40.00	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
40.00	Single	7T8X	Acetylcholine	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
40.00	Single	7T90	Acetylcholine	7T90-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
40.00	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00	Single	7YM8	Oxymetazoline	7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
40.00	Single	7YMH	Norepinephrine	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
40.00	Single	8A6C	All-trans-retinal	8A6C-Rhodopsin-All-trans-retinal
40.00	Single	8A6D	All-trans-retinal	8A6D-Rhodopsin-All-trans-retinal
40.00	Single	8A6E	All-trans-retinal	8A6E-Rhodopsin-All-trans-retinal
40.00	Single	8EFO	PZM21	8EFO-μ-PZM21-Gi1/&β;1/&γ;2
40.00	Single	8GEC	Epinephrine	8GEC-β₂-Epinephrine-Gs/&β;1/&γ;2
40.00	Single	8GEF	Epinephrine	8GEF-β₂-Epinephrine-Gs/&β;1/&γ;2
40.00	Single	8GG9	Epinephrine	8GG9-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00	Single	8GGA	Epinephrine	8GGA-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00	Single	8GGF	Epinephrine	8GGF-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00	Single	8GGV	Epinephrine	8GGV-β₂-Epinephrine
40.00	Single	8GGW	Epinephrine	8GGW-β₂-Epinephrine
40.00	Single	8GGX	Epinephrine	8GGX-β₂-Epinephrine
40.00	Single	8GH0	Epinephrine	8GH0-β₂-Epinephrine
40.00	Single	8HOC	Imetit	8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
40.00	Single	8IW4	Spermidine	8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
40.00	Single	8IWE	Spermidine	8IWE-TAAR9-Spermidine
40.00	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
40.00	Single	8UNW	Epinephrine	8UNW-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00	Single	8UO3	Epinephrine	8UO3-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
40.00	Consensus	5ht2_on	Orthosteric Ligand	5ht2a_on 5ht2c_on
40.00	Consensus	alpha1_on	Orthosteric Ligand	alpha1a_on
40.00	Consensus	alpha1a_on	Orthosteric Ligand	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00	Consensus	alpha2a_off	Orthosteric Ligand	6KUX-α_2a-RS-79948
40.00	Consensus	gi_histamine	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2 8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
40.00	Consensus	gs_histamine	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00	Consensus	h4_on	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00	Consensus	m2_on	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
40.00	Consensus	mglu_on	Other Ligand	mglu2_on mglu4_on
40.00	Consensus	opsin_off	Orthosteric Ligand	1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
39.13	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
38.89	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/&β;1/&γ;2
38.89	Single	3UON	Quinuclidinyl benzilate hydrobromide	3UON-M₂-Quinuclidinyl benzilate hydrobromide
38.89	Single	4DJH	JDTic	4DJH-κ-JDTic
38.89	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
38.89	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
38.89	Single	5V54	Methiothepin	5V54-5-HT_1B-Methiothepin
38.89	Single	5ZKB	AF-DX 384	5ZKB-M₂-AF-DX 384
38.89	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
38.89	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
38.89	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/&β;1/&γ;2
38.89	Single	6OIJ	Iperoxo	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
38.89	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
38.89	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/&β;1/&γ;2
38.89	Single	7EPE	NAM563	7EPE-mGlu-NAM563
38.89	Single	7EW4	CYM5541	7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2
38.89	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/&β;1/&γ;2
38.89	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/&β;1/&γ;2
38.89	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
38.89	Single	7W41	PD176252	7W41-BB₂-PD176252
38.89	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/&β;1/&γ;2
38.89	Single	8E0G	BU72	8E0G-μ-BU72
38.89	Single	8EF5	Fentanyl	8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
38.89	Single	8JD0	J9R	8JD0-mGlu2; mGlu3-Glutamate-J9R
38.89	Single	8JXX	Clobenpropit	8JXX-H₄-Clobenpropit-Gi1/&β;1/&γ;2
38.89	Single	8X16	Piclidenoson	8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
38.89	Consensus	5ht1_off	Orthosteric Ligand	5ht1b_off
38.89	Consensus	5ht1b_off	Orthosteric Ligand	5V54-5-HT_1B-Methiothepin
38.89	Consensus	a2_on	Orthosteric Ligand	a2a_on a2b_on
38.89	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
38.89	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
38.89	Consensus	gi_dopamine	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
38.89	Consensus	go_adrenergic	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
38.89	Consensus	h1_off	Orthosteric Ligand	3RZE-H₁-Cidoxepin 8X5Y-H₁-Astemizole 8X63-H₁-Mepyramine 8X64-H₁-Desloratadine
38.89	Consensus	histamine_off	Orthosteric Ligand	h1_off
38.89	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
38.89	Consensus	muscarinic_off	Orthosteric Ligand	m2_off m3_off m4_off m5_off m1_off
38.46	Single	2HPY	All-trans-retinal	2HPY-Rhodopsin-All-trans-retinal
38.46	Single	7MTB	All-trans-retinal	7MTB-Rhodopsin-All-trans-retinal-GRK1
38.46	Single	8DPH	Lorcaserin	8DPH-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.46	Single	8IWM	2-Phenylethylamine	8IWM-TAAR9-2-Phenylethylamine
38.46	Single	8WC5	Tetramethylammonium ion	8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
38.46	Consensus	sensory_on	Orthosteric Ligand	opsin_on
38.10	Single	4AMJ	(S)-Carvedilol	4AMJ-β₁-(S)-Carvedilol
38.10	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.10	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
38.10	Consensus	mop_off	Orthosteric Ligand	7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
37.50	Single	3OAX	11-cis-Retinal	3OAX-Rhodopsin-11-cis-Retinal
37.50	Single	4DKL	Beta-funaltrexamine	4DKL-μ-Beta-funaltrexamine
37.50	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
37.50	Single	4ZJC	SB-674042	4ZJC-OX₁-SB-674042
37.50	Single	5TE3	Octyl Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
37.50	Single	6DS0	Ly266097	6DS0-5-HT_2B-Ly266097
37.50	Single	6IQL	L745870	6IQL-D₄-L745870
37.50	Single	6PS5	(S)-Propranolol	6PS5-β₂-(S)-Propranolol
37.50	Single	6TOS	GSK1059865	6TOS-OX₁-GSK1059865-Na
37.50	Single	6TP3	Nemorexant	6TP3-OX₁-Nemorexant
37.50	Single	6TPG	EMPA	6TPG-OX₂-EMPA
37.50	Single	6TPN	HTL6641	6TPN-OX₂-HTL6641
37.50	Single	6WH4	Methiothepin	6WH4-5-HT_2A-Methiothepin
37.50	Single	7CMU	Pramipexole	7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
37.50	Single	7CMV	PD128907	7CMV-D₃-PD128907-Gi1/&β;1/&γ;2
37.50	Single	7DHI	Salbutamol	7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2
37.50	Single	7E33	BRL-54443	7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2
37.50	Single	7RAN	PubChem 164575847	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50	Single	7SR8	TAK-925	7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
37.50	Single	7T94	Acetylcholine	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
37.50	Single	7TRS	Acetylcholine	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2
37.50	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
37.50	Single	7ZBC	11-cis-Retinal	7ZBC-Rhodopsin-11-cis-Retinal
37.50	Single	8FCZ	11-cis-Retinal	8FCZ-Rhodopsin-11-cis-Retinal
37.50	Single	8GE1	Epinephrine	8GE1-β₂-Epinephrine-Gs/&β;1/&γ;2
37.50	Single	8GE4	Epinephrine	8GE4-β₂-Epinephrine-Gs/&β;1/&γ;2
37.50	Single	8GE6	Epinephrine	8GE6-β₂-Epinephrine-Gs/&β;1/&γ;2
37.50	Single	8GE7	Epinephrine	8GE7-β₂-Epinephrine-Gs/&β;1/&γ;2
37.50	Single	8GE8	Epinephrine	8GE8-β₂-Epinephrine-Gs/&β;1/&γ;2
37.50	Single	8GE9	Epinephrine	8GE9-β₂-Epinephrine-Gs/&β;1/&γ;2
37.50	Single	8GFV	Epinephrine	8GFV-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50	Single	8GG3	Epinephrine	8GG3-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50	Single	8GG4	Epinephrine	8GG4-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50	Single	8GG5	Epinephrine	8GG5-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50	Single	8GGI	Epinephrine	8GGI-β₂-Epinephrine
37.50	Single	8GGK	Epinephrine	8GGK-β₂-Epinephrine
37.50	Single	8GGM	Epinephrine	8GGM-β₂-Epinephrine
37.50	Single	8GGP	Epinephrine	8GGP-β₂-Epinephrine
37.50	Single	8GGT	Epinephrine	8GGT-β₂-Epinephrine
37.50	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
37.50	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
37.50	Single	8THK	A61603	8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/&β;1/&γ;2
37.50	Single	8UNQ	Epinephrine	8UNQ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50	Single	8UNR	Epinephrine	8UNR-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50	Single	8UNS	Epinephrine	8UNS-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50	Consensus	5ht1e_on	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2
37.50	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6WH4-5-HT_2A-Methiothepin 7VOE-5-HT_2A-Aripiprazole 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 6A93-5-HT_2A-Risperidone
37.50	Consensus	5ht2a_on	Orthosteric Ligand	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50	Consensus	at1_off	Orthosteric Ligand	4YAY-AT₁-ZD-7155 4ZUD-AT₁-Olmesartan
37.50	Consensus	d3_on	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
37.50	Consensus	dop_off_allo	Orthosteric Ligand	4N6H-δ-Naltrindole-Na
37.50	Consensus	ghrelin_off	Orthosteric Ligand	6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
37.50	Consensus	ox1_off	Orthosteric Ligand	6TOT-OX₁-Lemborexant 6TP4-OX₁-ACT-462206 6TP6-OX₁-Filorexant 6V9S-OX₁-GTPL11403 6TP3-OX₁-Nemorexant 6TQ6-OX₁-PubChem 145714283 6TQ7-OX₁-SB-334867 6TQ9-OX₁-SB-408124 4ZJC-OX₁-SB-674042 4ZJ8-OX₁-Suvorexant
37.50	Consensus	ox2_off	Orthosteric Ligand	6TPN-OX₂-HTL6641 7XRR-OX₂-Lemborexant
37.50	Consensus	sensory_off	Orthosteric Ligand	opsin_off
36.84	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
36.84	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
36.84	Single	5CXV	Tiotropium	5CXV-M₁-Tiotropium
36.84	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
36.84	Single	6H7N	(S)-Xamoterol	6H7N-β₁-(S)-Xamoterol
36.84	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
36.84	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
36.84	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
36.84	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
36.84	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
36.84	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
36.84	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
36.84	Single	7JNI	Olodanrigan	7JNI-AT₂-Olodanrigan
36.84	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
36.84	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
36.84	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.84	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
36.84	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
36.84	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
36.84	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
36.84	Consensus	at2_off	Orthosteric Ligand	7JNI-AT₂-Olodanrigan
36.84	Consensus	blt1_off	Orthosteric Ligand	7K15-BLT₁-MKD046-Na
36.84	Consensus	blt_off	Orthosteric Ligand	blt1_off
36.84	Consensus	go_5ht	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
36.84	Consensus	gs_trh	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.84	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
36.84	Consensus	m1_off	Orthosteric Ligand	5CXV-M₁-Tiotropium
36.84	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
36.84	Consensus	peptide_off	Orthosteric Ligand	opioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
36.84	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.36	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
36.36	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
36.36	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
35.71	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
35.71	Single	3PQR	All-trans-retinal	3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
35.71	Single	3UZA	GTPL9236	3UZA-A_2A-GTPL9236
35.71	Single	6FUF	All-trans-retinal	6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
35.71	Single	7MT8	All-trans-retinal	7MT8-Rhodopsin-All-trans-retinal-GRK1
35.71	Single	7MT9	All-trans-retinal	7MT9-Rhodopsin-All-trans-retinal-GRK1
35.71	Single	7MTA	All-trans-retinal	7MTA-Rhodopsin-All-trans-retinal-GRK1
35.71	Single	8GGR	Epinephrine	8GGR-β₂-Epinephrine
35.71	Single	8GGZ	Epinephrine	8GGZ-β₂-Epinephrine
35.71	Single	8IW7	2-Phenylethylamine	8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
35.71	Single	8J6Q	Beta-hydroxybutyrate	8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
35.71	Single	8JXT	Histamine	8JXT-H₄-Histamine-PO4-Gi1/&β;1/&γ;2
35.71	Single	8WC9	ZH8651	8WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.71	Consensus	opsin_on	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
35.29	Single	1HZX	11-cis-Retinal	1HZX-Rhodopsin-11-cis-Retinal
35.29	Single	2Y01	Dobutamine	2Y01-β₁-Dobutamine
35.29	Single	2Y02	Carmoterol	2Y02-β₁-Carmoterol
35.29	Single	4DAJ	Tiotropium	4DAJ-M₃-Tiotropium
35.29	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
35.29	Single	4QKX	PubChem 76210628	4QKX-β₂-PubChem 76210628
35.29	Single	4YAY	ZD-7155	4YAY-AT₁-ZD-7155
35.29	Single	4ZUD	Olmesartan	4ZUD-AT₁-Olmesartan
35.29	Single	5DSG	Tiotropium	5DSG-M₄-Tiotropium
35.29	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
35.29	Single	5YC8	N-Methyl Scopolamine	5YC8-M₂-N-Methyl Scopolamine
35.29	Single	5ZK8	N-Methyl Scopolamine	5ZK8-M₂-N-Methyl Scopolamine
35.29	Single	5ZKC	N-Methyl Scopolamine	5ZKC-M₂-N-Methyl Scopolamine
35.29	Single	6DRZ	Methysergide	6DRZ-5-HT_2B-Methysergide
35.29	Single	6H7M	Salbutamol	6H7M-β₁-Salbutamol
35.29	Single	6TOT	Lemborexant	6TOT-OX₁-Lemborexant
35.29	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/&β;1/&γ;2
35.29	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
35.29	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
35.29	Single	7SQO	TAK-925	7SQO-OX₂-TAK-925-Gi1/&β;1/&γ;2
35.29	Single	7T2G	Mitragynine pseudoindoxyl	7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
35.29	Single	7UM6	Lisuride	7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
35.29	Single	7WC7	Lisuride	7WC7-5-HT_2A-Lisuride
35.29	Single	7XJH	Isoproterenol	7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
35.29	Single	7XTC	5-CT	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
35.29	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
35.29	Single	8GEB	Epinephrine	8GEB-β₂-Epinephrine-Gs/&β;1/&γ;2
35.29	Single	8GGB	Epinephrine	8GGB-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29	Single	8IRT	Rotigotine	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2
35.29	Single	8JLJ	T1AM	8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
35.29	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
35.29	Single	8UNM	Epinephrine	8UNM-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
35.29	Single	8X17	Namodenoson	8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
35.29	Single	8X63	Mepyramine	8X63-H₁-Mepyramine
35.29	Single	8X64	Desloratadine	8X64-H₁-Desloratadine
35.29	Consensus	5ht7_on	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
35.29	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
35.29	Consensus	d5_on	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
35.29	Consensus	gi_5ht	Orthosteric Ligand	7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT_5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2
35.29	Consensus	gi_hca	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
35.29	Consensus	gi_hcar	Orthosteric Ligand	gi_hca
35.29	Consensus	go_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
35.29	Consensus	gq_amine	Orthosteric Ligand	gq_muscarinic gq_histamine
35.29	Consensus	hca2_on	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA₂-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
35.29	Consensus	histamine_on	Orthosteric Ligand	h1_on h4_on
35.29	Consensus	m2_on_allo	Orthosteric Ligand	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
35.29	Consensus	m4_off	Orthosteric Ligand	5DSG-M₄-Tiotropium
35.29	Consensus	muscarinic_on	Orthosteric Ligand	m2_on m3_on m4_on m1_on
35.29	Consensus	tar_on	Orthosteric Ligand	ta1_on
35.00	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
35.00	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
35.00	Single	5UNG	PubChem 15780052	5UNG-AT₂-PubChem 15780052
35.00	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
35.00	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
35.00	Single	7EZC	UKA	7EZC-A_2A-UKA
35.00	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
35.00	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
35.00	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
35.00	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
35.00	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2
35.00	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/&β;1/&γ;2
35.00	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
35.00	Single	8E9Y	PubChem 446603	8E9Y-M₃-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
35.00	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00	Consensus	5ht5a_off	Orthosteric Ligand	7UM4-5-HT_5A-AS2674723
35.00	Consensus	ffa4_on_allo	Orthosteric Ligand	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
34.78	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
33.33	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
33.33	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
33.33	Single	4WW3	All-trans-retinal	4WW3-Rhodopsin-All-trans-retinal
33.33	Single	4ZJ8	Suvorexant	4ZJ8-OX₁-Suvorexant
33.33	Single	5C1M	BU72	5C1M-μ-BU72
33.33	Single	5CGC	HTL14242	5CGC-mGlu₅-HTL14242
33.33	Single	5MZP	Caffeine	5MZP-A_2A-Caffeine-Na
33.33	Single	5N2S	PSB36	5N2S-A₁-PSB36
33.33	Single	5NM2	ZM241385	5NM2-A_2A-ZM241385-Na
33.33	Single	5WQC	EMPA	5WQC-OX₂-EMPA
33.33	Single	5ZK3	Quinuclidinyl benzilate hydrobromide	5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
33.33	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
33.33	Single	6E67	BI167107	6E67-β₂-BI167107-Gs (fused)
33.33	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
33.33	Single	6HLL	CP99994	6HLL-NK₁-CP99994
33.33	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
33.33	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
33.33	Single	6OIK	Iperoxo	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
33.33	Single	6PT3	DPI-287	6PT3-δ-DPI-287
33.33	Single	6QNO	All-trans-retinal	6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
33.33	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
33.33	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
33.33	Single	6TQ4	PubChem 16046844	6TQ4-OX₁-PubChem 16046844-Na
33.33	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/&β;1/&γ;2
33.33	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
33.33	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/&β;1/&γ;2
33.33	Single	7SRQ	LSD	7SRQ-5-HT_2B-LSD
33.33	Single	7V68	Iperoxo	7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
33.33	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
33.33	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
33.33	Single	7WC6	LSD	7WC6-5-HT_2A-LSD
33.33	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
33.33	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/&β;1/&γ;2
33.33	Single	7YFC	Histamine	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33	Single	7YFD	Imetit	7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33	Single	7YS6	Serotonin	7YS6-5-HT₆-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
33.33	Single	8DPF	Lorcaserin	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33	Single	8EA0	Iperoxo	8EA0-M₃-Iperoxo
33.33	Single	8GGC	Epinephrine	8GGC-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33	Single	8GGE	Epinephrine	8GGE-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33	Single	8GGS	Epinephrine	8GGS-β₂-Epinephrine
33.33	Single	8GGY	Epinephrine	8GGY-β₂-Epinephrine
33.33	Single	8GH1	Epinephrine	8GH1-β₂-Epinephrine
33.33	Single	8HN8	Histamine	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2
33.33	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
33.33	Single	8UNV	Epinephrine	8UNV-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33	Single	8UNX	Epinephrine	8UNX-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
33.33	Single	8W8B	SEP-363856	8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2
33.33	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
33.33	Consensus	5ht2b_off	Orthosteric Ligand	6DRZ-5-HT_2B-Methysergide 6DRX-5-HT_2B-Lisuride
33.33	Consensus	5ht4_on	Orthosteric Ligand	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
33.33	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
33.33	Consensus	a2a_on	Orthosteric Ligand	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
33.33	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
33.33	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
33.33	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
33.33	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
33.33	Consensus	gs_adrenergic	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJI-β₃-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
33.33	Consensus	gs_muscarinic	Orthosteric Ligand	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
33.33	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
33.33	Consensus	m3_on	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
32.14	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
32.14	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
32.00	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
31.82	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
31.82	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
31.82	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
31.82	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
31.82	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
31.82	Single	8G59	TUG-891	8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
31.82	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
31.58	Single	3P0G	BI167107	3P0G-β₂-BI167107
31.58	Single	3PDS	Hydroxybenzylisoproterenol	3PDS-β₂-Hydroxybenzylisoproterenol
31.58	Single	4LDL	Hydroxybenzylisoproterenol	4LDL-β₂-Hydroxybenzylisoproterenol
31.58	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
31.58	Single	4U15	Tiotropium	4U15-M₃-Tiotropium
31.58	Single	6E59	L-760735	6E59-NK₁-L-760735
31.58	Single	6OL9	Tiotropium	6OL9-M₅-Tiotropium
31.58	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
31.58	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
31.58	Single	7M8W	15r-Methyl-Prostaglandin D2	7M8W-DP₂-15r-Methyl-Prostaglandin D2-Na
31.58	Single	7TRQ	Iperoxo	7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
31.58	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
31.58	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2
31.58	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/&β;1/&γ;2
31.58	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
31.58	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2
31.58	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
31.58	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
31.58	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/&β;1/&γ;2
31.58	Consensus	5ht1b_on	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
31.58	Consensus	5ht5_off	Orthosteric Ligand	5ht5a_off
31.58	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
31.58	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
31.58	Consensus	alpha1b_off	Orthosteric Ligand	7B6W-α_1b-Cyclazosin
31.58	Consensus	angiotensin_off	Orthosteric Ligand	at1_off at2_off
31.58	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A_2A-NECA-Gs/&β;1/&γ;1 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
31.58	Consensus	gs_compl-peptide	Orthosteric Ligand	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
31.58	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
31.58	Consensus	m3_off	Orthosteric Ligand	4U15-M₃-Tiotropium 4U16-M₃-N-Methyl Scopolamine 5ZHP-M₃-PubChem 134828589
31.58	Consensus	m5_off	Orthosteric Ligand	6OL9-M₅-Tiotropium
31.58	Consensus	nk1_off	Orthosteric Ligand	6J20-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
31.58	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
31.58	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
31.25	Single	3VGA	ZM241385	3VGA-A_2A-ZM241385-Antibody
31.25	Single	6AKX	A4R	6AKX-CCR5-A4R
31.25	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/&β;1/&γ;2
31.25	Single	6NWE	Octyl Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
31.25	Single	6OBA	(S)-Alprenolol	6OBA-β₂-(S)-Alprenolol-GTPL11074
31.25	Single	6OYA	All-trans-retinal	6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
31.25	Single	6TQ6	PubChem 145714283	6TQ6-OX₁-PubChem 145714283
31.25	Single	7DHR	Isoprenaline	7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2
31.25	Single	7F24	Dopamine	7F24-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
31.25	Single	7SRR	LSD	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
31.25	Single	7X5H	5-CT	7X5H-5-HT_5A-5-CT-Gi1/&β;1/&γ;2
31.25	Single	7XRR	Lemborexant	7XRR-OX₂-Lemborexant
31.25	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
31.25	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
31.25	Single	8GEA	Epinephrine	8GEA-β₂-Epinephrine-Gs/&β;1/&γ;2
31.25	Single	8GED	Epinephrine	8GED-β₂-Epinephrine-Gs/&β;1/&γ;2
31.25	Single	8GG7	Epinephrine	8GG7-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
31.25	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2
31.25	Single	8UNL	Epinephrine	8UNL-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25	Single	8UNO	Epinephrine	8UNO-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25	Single	8UNT	Epinephrine	8UNT-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25	Single	8UNU	Epinephrine	8UNU-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
31.25	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
31.25	Consensus	5ht_on	Orthosteric Ligand	5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
31.25	Consensus	a2a_off_allo	Orthosteric Ligand	6ZDR-A_2A-HMS1413f12-Na 6GT3-A_2A-Imaradenant-Na 8CU7-A_2A-LJ-4517-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PubChem 92460631; psb36-Na 5MZJ-A_2A-Theophylline-Na 5OLO-A_2A-Tozadenant-Na 5OLH-A_2A-Vipadenant-Na 5NM4-A_2A-ZM241385-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5MZP-A_2A-Caffeine-Na 8CIC-A_2A-Etrumadenant-Na
31.25	Consensus	beta2_off_allo	Orthosteric Ligand	6OBA-β₂-(S)-Alprenolol-GTPL11074
31.25	Consensus	gs_5ht	Orthosteric Ligand	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25	Consensus	gt_class-a	Orthosteric Ligand	gt_opsin
31.25	Consensus	gt_opsin	Orthosteric Ligand	gt_sensory
31.25	Consensus	gt_sensory	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
31.25	Consensus	melatonin_on	Orthosteric Ligand	mt1_on mt2_on
31.25	Consensus	orexin_off	Orthosteric Ligand	ox2_off ox1_off
30.77	Single	3PXO	All-trans-retinal	3PXO-Rhodopsin-All-trans-retinal
30.77	Single	5DYS	All-trans-retinal	5DYS-Rhodopsin-All-trans-retinal
30.77	Single	5MZJ	Theophylline	5MZJ-A_2A-Theophylline-Na
30.77	Single	8GEJ	Epinephrine	8GEJ-β₂-Epinephrine-Gs/&β;1/&γ;2
30.77	Single	8PWN	Theophylline	8PWN-A_2A-Theophylline
30.00	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
30.00	Single	6DRY	Methylergonovine	6DRY-5-HT_2B-Methylergonovine
30.00	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
30.00	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
30.00	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
30.00	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2
30.00	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.00	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
30.00	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
30.00	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
30.00	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
30.00	Single	8I95	EP54	8I95-C3a_B-EP54-Go/&β;1/&γ;2
30.00	Single	8I9L	C3a anaphylatoxin	8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2
30.00	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2
30.00	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
30.00	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
30.00	Single	8JWY	PubChem 168451710	8JWY-A_2A-PubChem 168451710
30.00	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
30.00	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg3_on
30.00	Consensus	beta1_on	Orthosteric Ligand	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
30.00	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
30.00	Consensus	class-b2_on	Orthosteric Ligand	adgrg_on
30.00	Consensus	gi_class-f	Other Ligand	gi_frizzled
30.00	Consensus	gi_frizzled	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
30.00	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
29.63	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
29.41	Single	3RZE	Cidoxepin	3RZE-H₁-Cidoxepin
29.41	Single	4MBS	Maraviroc	4MBS-CCR5-Maraviroc
29.41	Single	4MQT	Iperoxo	4MQT-M₂-Iperoxo-LY2119620
29.41	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
29.41	Single	5JTB	ZM241385	5JTB-A_2A-ZM241385
29.41	Single	5K2B	ZM241385	5K2B-A_2A-ZM241385-Na
29.41	Single	6A94	Zotepine	6A94-5-HT_2A-Zotepine
29.41	Single	6AQF	ZM241385	6AQF-A_2A-ZM241385
29.41	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
29.41	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
29.41	Single	6MH8	ZM241385	6MH8-A_2A-ZM241385
29.41	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
29.41	Single	6TPK	Retosiban	6TPK-OT-Retosiban
29.41	Single	6VI4	JDTic	6VI4-κ-JDTic
29.41	Single	6WJC	Atropine	6WJC-M₁-Atropine-Muscarinic toxin 7
29.41	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
29.41	Single	6ZG9	GSK1034702	6ZG9-M₁-GSK1034702
29.41	Single	7ARO	LUF5833	7ARO-A_2A-LUF5833-Na
29.41	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/&β;1/&γ;2
29.41	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
29.41	Single	7EJ8	Brimonidine	7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2
29.41	Single	7EJA	Dexmedetomidine	7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
29.41	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2
29.41	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
29.41	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/&β;1/&γ;2
29.41	Single	7T32	ZM241385	7T32-A_2A-ZM241385
29.41	Single	7UM7	Methylergometrine	7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
29.41	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
29.41	Single	8DPG	Psilocin	8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41	Single	8GDZ	Epinephrine	8GDZ-β₂-Epinephrine-Gs/&β;1/&γ;2
29.41	Single	8GG8	Epinephrine	8GG8-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41	Single	8GGL	Epinephrine	8GGL-β₂-Epinephrine
29.41	Single	8HNM	VUF11222	8HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
29.41	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
29.41	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/&β;1/&γ;2
29.41	Single	8JIM	MMF	8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2
29.41	Single	8JSP	Ulotaront	8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2
29.41	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
29.41	Consensus	5ht5_on	Orthosteric Ligand	5ht5a_on
29.41	Consensus	5ht5a_on	Orthosteric Ligand	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
29.41	Consensus	d1_on_allo	Orthosteric Ligand	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
29.41	Consensus	gi_melatonin	Orthosteric Ligand	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
29.41	Consensus	gs_tar	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
29.41	Consensus	hca_on	Orthosteric Ligand	hca2_on hca3_on
29.41	Consensus	hcar_on	Orthosteric Ligand	hca_on
29.41	Consensus	m1_off_allo	Orthosteric Ligand	6WJC-M₁-Atropine-Muscarinic toxin 7
29.41	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
29.41	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
29.41	Consensus	vasopressin-ot_off	Orthosteric Ligand	ot_off
29.17	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
29.17	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
28.57	Single	3RFM	Caffeine	3RFM-A_2A-Caffeine
28.57	Single	5CGD	HTL14242	5CGD-mGlu₅-HTL14242
28.57	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
28.57	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/&β;1/&γ;2
28.57	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
28.57	Single	6OY9	All-trans-retinal	6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
28.57	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
28.57	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
28.57	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
28.57	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/&β;1/&γ;2
28.57	Single	7Y65	C5a peptide	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
28.57	Single	8A2O	Theophylline	8A2O-A_2A-Theophylline-Na
28.57	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
28.57	Consensus	bileacid_on	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
28.57	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
28.57	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
28.57	Consensus	gs_orexin	Orthosteric Ligand	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
28.57	Consensus	hca2_on_allo	Orthosteric Ligand	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
28.57	Consensus	orexin_on	Orthosteric Ligand	ox2_on
28.57	Consensus	steroid_on	Orthosteric Ligand	bileacid_on
28.00	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
28.00	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
28.00	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
28.00	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78	Single	3EML	ZM241385	3EML-A_2A-ZM241385
27.78	Single	4EIY	ZM241385	4EIY-A_2A-ZM241385-Na
27.78	Single	4MQS	Iperoxo	4MQS-M₂-Iperoxo
27.78	Single	4U14	Tiotropium	4U14-M₃-Tiotropium
27.78	Single	5DHG	PubChem 25001412	5DHG-NOP-PubChem 25001412
27.78	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
27.78	Single	5K2A	ZM241385	5K2A-A_2A-ZM241385-Na
27.78	Single	5OLG	ZM241385	5OLG-A_2A-ZM241385-Na
27.78	Single	5UEN	DU172	5UEN-A₁-DU172
27.78	Single	5UIG	J3.651.884G	5UIG-A_2A-J3.651.884G
27.78	Single	5VRA	ZM241385	5VRA-A_2A-ZM241385-Na
27.78	Single	6DRX	Lisuride	6DRX-5-HT_2B-Lisuride
27.78	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
27.78	Single	6GPS	MK0812	6GPS-CCR2-MK0812
27.78	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
27.78	Single	6S0L	ZM241385	6S0L-A_2A-ZM241385
27.78	Single	6WHA	DB13948	6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78	Single	6Z10	PubChem 154585554	6Z10-Succinate-PubChem 154585554
27.78	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
27.78	Single	7LJC	PubChem 86764103	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
27.78	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
27.78	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/&β;1/&γ;2
27.78	Single	7T6V	fMLFII	7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
27.78	Single	7TRP	Iperoxo	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
27.78	Single	7VH0	Ramelteon	7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
27.78	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
27.78	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
27.78	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
27.78	Single	7YAC	Paltusotine	7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
27.78	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
27.78	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/&β;1/&γ;2
27.78	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/&β;1/&γ;2
27.78	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
27.78	Single	8J18	(3R)-3-hydroxydodecanoic acid	8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
27.78	Single	8JII	Niacin	8JII-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
27.78	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
27.78	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
27.78	Single	8WC7	ZH8667	8WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
27.78	Consensus	5ht1a_on	Orthosteric Ligand	8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2
27.78	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
27.78	Consensus	a2_off	Orthosteric Ligand	a2a_off
27.78	Consensus	a2a_off	Orthosteric Ligand	8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 5UIG-A_2A-J3.651.884G 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-PubChem 168451710 5K2D-A_2A-ZM241385
27.78	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
27.78	Consensus	m4_on_allo	Orthosteric Ligand	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
27.78	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
27.78	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
27.59	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
27.59	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
27.59	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
27.59	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
27.59	Consensus	gs_crf	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
27.27	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
27.27	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
27.27	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
27.27	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
27.27	Single	7XY6	PubChem 11717831	7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
27.27	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2 8I95-C3a_B-EP54-Go/&β;1/&γ;2
27.27	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
27.27	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
27.27	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
26.92	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
26.92	Consensus	bombesin_on	Orthosteric Ligand	bb2_on bb1_on
26.92	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
26.67	Single	5WKT	Octyl Beta-D-Glucopyranoside	5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
26.67	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
26.67	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
26.67	Single	7WC5	Psilocin	7WC5-5-HT_2A-Psilocin
26.67	Single	8DPI	Lorcaserin	8DPI-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.67	Single	8POK	Histamine	8POK-H₂-Histamine-Gs/&β;1/&γ;2
26.67	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
26.32	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
26.32	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
26.32	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
26.32	Single	6D26	Fevipiprant	6D26-DP₂-Fevipiprant
26.32	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/&β;1/&γ;2
26.32	Single	6GPX	MK0812	6GPX-CCR2-MK0812
26.32	Single	6LPL	ZM241385	6LPL-A_2A-ZM241385-Na
26.32	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
26.32	Single	6S0Q	ZM241385	6S0Q-A_2A-ZM241385
26.32	Single	6WQA	ZM241385	6WQA-A_2A-ZM241385-Na
26.32	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
26.32	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
26.32	Single	7C4S	S1P	7C4S-S1P₃-S1P
26.32	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2
26.32	Single	7RM5	ZM241385	7RM5-A_2A-ZM241385-Na
26.32	Single	7TRK	Iperoxo	7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2
26.32	Single	8FYN	ZM241385	8FYN-A_2A-ZM241385-Na
26.32	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
26.32	Single	8HNL	PS372424	8HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
26.32	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
26.32	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
26.32	Single	8J19	PubChem 127045422	8J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
26.32	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
26.32	Single	8QOT	Nanobody E	8QOT-μ-Nanobody E
26.32	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
26.32	Consensus	d4_off	Orthosteric Ligand	5WIU-D₄-Nemonapride
26.32	Consensus	d4_off_allo	Orthosteric Ligand	5WIV-D₄-Nemonapride-Na
26.09	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
26.09	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
26.09	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
26.09	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/&β;1/&γ;2
26.09	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
26.09	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
26.09	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
26.09	Consensus	sst_on	Orthosteric Ligand	sst2_on sst4_on
25.93	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
25.93	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
25.93	Consensus	gi_neuromedin	Orthosteric Ligand	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
25.93	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
25.81	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
25.00	Single	3OE9	IT1t	3OE9-CXCR4-IT1t
25.00	Single	4IAQ	Dihydroergotamine	4IAQ-5-HT_1B-Dihydroergotamine
25.00	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
25.00	Single	4OO9	Mavoglurant	4OO9-mGlu₅-Mavoglurant
25.00	Single	5OLV	LUAA41063	5OLV-A_2A-LUAA41063-Na
25.00	Single	5XRA	AM11542	5XRA-CB₁-AM11542
25.00	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
25.00	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
25.00	Single	6I9K	9-cis-Retinal	6I9K-Rhodopsin-9-cis-Retinal
25.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
25.00	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
25.00	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
25.00	Single	6TP4	ACT-462206	6TP4-OX₁-ACT-462206
25.00	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
25.00	Single	7DFL	Histamine	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00	Single	7E2Y	Serotonin	7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2
25.00	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2
25.00	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
25.00	Single	7FEE	PubMed 104895	7FEE-CB₁-PubMed 104895-ZCZ011
25.00	Single	7P2L	4YI	7P2L-mGlu₅-4YI
25.00	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
25.00	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
25.00	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
25.00	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
25.00	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
25.00	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
25.00	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
25.00	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2
25.00	Single	7XTB	Serotonin	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2
25.00	Single	8A2P	LUAA47070	8A2P-A_2A-LUAA47070-Na
25.00	Single	8EF6	Morphine	8EF6-μ-Morphine-Gi1/&β;1/&γ;2
25.00	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2
25.00	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
25.00	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
25.00	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2
25.00	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2
25.00	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/&β;1/&γ;2
25.00	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/&β;1/&γ;2
25.00	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/&β;1/&γ;2
25.00	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
25.00	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
25.00	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/&β;1/&γ;2
25.00	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
25.00	Single	8TAO	CDPPB	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
25.00	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
25.00	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off alpha1b_off
25.00	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
25.00	Consensus	ffa4_on	Orthosteric Ligand	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
25.00	Consensus	gi_ffa	Orthosteric Ligand	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
25.00	Consensus	gi_muscarinic	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
25.00	Consensus	gq_histamine	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00	Consensus	gs_ffa	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2 8GDB-EP₄-PGE2-Gs/&β;1/&γ;2
25.00	Consensus	h1_on	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
25.00	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
25.00	Consensus	mt1_on	Orthosteric Ligand	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
25.00	Consensus	mt2_on	Orthosteric Ligand	7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
25.00	Consensus	s1p2_on	Orthosteric Ligand	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
25.00	Consensus	sst4_on	Orthosteric Ligand	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
24.24	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
24.14	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
24.14	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
24.14	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
24.14	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
24.00	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
24.00	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
24.00	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
24.00	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;2
24.00	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
24.00	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
23.81	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
23.81	Single	5X33	BIIL260	5X33-BLT₁-BIIL260
23.81	Single	6KQI	PubMed 104895	6KQI-CB₁-PubMed 104895-ORG27569
23.81	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2
23.81	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
23.81	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
23.81	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/&β;1/&γ;2
23.81	Single	8WU1	KCA	8WU1-CB₁-KCA-Arrestin1
23.81	Consensus	cb1_off_allo	Orthosteric Ligand	6KQI-CB₁-PubMed 104895-ORG27569
23.81	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
23.81	Consensus	dp_off	Orthosteric Ligand	dp2_off
23.81	Consensus	gs_bileacid	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
23.81	Consensus	gs_steroid	Orthosteric Ligand	gs_bileacid
23.81	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
23.53	Single	3PWH	ZM241385	3PWH-A_2A-ZM241385
23.53	Single	3VG9	ZM241385	3VG9-A_2A-ZM241385-Antibody
23.53	Single	5DHH	SB-612111	5DHH-NOP-SB-612111
23.53	Single	5K2D	ZM241385	5K2D-A_2A-ZM241385
23.53	Single	5OLH	Vipadenant	5OLH-A_2A-Vipadenant-Na
23.53	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
23.53	Single	6AKY	Maraviroc	6AKY-CCR5-Maraviroc
23.53	Single	6JZH	ZM241385	6JZH-A_2A-ZM241385-Na
23.53	Single	6PS7	ZM241385	6PS7-A_2A-ZM241385-Na
23.53	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
23.53	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
23.53	Single	7F8U	Lintitript	7F8U-CCK_A-Lintitript
23.53	Single	7LJD	Dopamine	7LJD-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;1
23.53	Single	7SRS	LSD	7SRS-5-HT_2B-LSD-Arrestin2
23.53	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
23.53	Single	7W0M	PubChem 122701908	7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
23.53	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
23.53	Single	7X2F	Dopamine	7X2F-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
23.53	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
23.53	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2
23.53	Single	8UO1	Epinephrine	8UO1-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
23.53	Consensus	5ht2c_on	Orthosteric Ligand	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
23.08	Single	4A4M	All-trans-retinal	4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
23.08	Single	5EN0	All-trans-retinal	5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
23.08	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
23.08	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
23.08	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
23.08	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2
23.08	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/&β;1/&γ;2
23.08	Single	8WCC	Cyclohexylammonium ion	8WCC-TA1-Cyclohexylammonium ion
23.08	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
23.08	Consensus	gi_somatostatin	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
23.08	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
23.08	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
22.73	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
22.73	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
22.73	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
22.73	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
22.73	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2
22.73	Single	8ID8	TUG-891	8ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
22.73	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73	Single	8K2X	CXCL10	8K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
22.73	Single	8WRZ	8D0	8WRZ-CB₁-8D0-Arrestin1
22.58	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
22.22	Single	3REY	PubChem 5697	3REY-A_2A-PubChem 5697
22.22	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
22.22	Single	5IU4	ZM241385	5IU4-A_2A-ZM241385-Na
22.22	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
22.22	Single	5K2C	ZM241385	5K2C-A_2A-ZM241385-Na
22.22	Single	5NLX	ZM241385	5NLX-A_2A-ZM241385-Na
22.22	Single	5NM4	ZM241385	5NM4-A_2A-ZM241385-Na
22.22	Single	5UVI	ZM241385	5UVI-A_2A-ZM241385
22.22	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
22.22	Single	6ZDV	PubChem 984073	6ZDV-A_2A-PubChem 984073-Na
22.22	Single	6ZFZ	77-LH-28-1	6ZFZ-M₁-77-LH-28-1
22.22	Single	7BB6	Acyclovir triphosphate	7BB6-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
22.22	Single	7F61	PF-03654746	7F61-H₃-PF-03654746-Cholesterol
22.22	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
22.22	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
22.22	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
22.22	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
22.22	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
22.22	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
22.22	Single	8DWG	ML382	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22	Single	8GUR	PubChem 104895	8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2
22.22	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
22.22	Single	8JHN	MMF	8JHN-HCA₂-MMF-Go/&β;1/&γ;2
22.22	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
22.22	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
22.22	Consensus	bk1_on	Orthosteric Ligand	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
22.22	Consensus	gs_bradykinin	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22	Consensus	h3_on_allo	Orthosteric Ligand	7F61-H₃-PF-03654746-Cholesterol
22.22	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
22.22	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
22.22	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
21.74	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
21.74	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
21.74	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
21.74	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
21.74	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
21.74	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
21.74	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/&β;1/&γ;2
21.74	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/&β;1/&γ;2
21.74	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
21.74	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
21.74	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
21.74	Consensus	gs_adgr	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
21.74	Consensus	gs_class-b2	Orthosteric Ligand	gs_adgr
21.74	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
21.74	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
21.43	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
21.43	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43	Single	7WC4	Serotonin	7WC4-5-HT_2A-Serotonin
21.43	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
21.43	Consensus	bb1_on	Orthosteric Ligand	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
21.43	Consensus	class-c_on	Other Ligand	gabab_on mglu_on
21.43	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
21.21	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
21.21	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
21.05	Single	5NDD	AZ8838; Na	5NDD-PAR2-AZ8838; Na
21.05	Single	6D27	CAY10471	6D27-DP₂-CAY10471
21.05	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
21.05	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
21.05	Single	6IIV	Daltroban	6IIV-TP-Daltroban
21.05	Single	6LPJ	ZM241385	6LPJ-A_2A-ZM241385-Na
21.05	Single	6LPK	ZM241385	6LPK-A_2A-ZM241385-Na
21.05	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
21.05	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
21.05	Single	7NA8	PubChem 178024	7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
21.05	Single	7V3Z	PubMed 104895	7V3Z-CB₁-PubMed 104895
21.05	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/&β;1/&γ;2
21.05	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
21.05	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
21.05	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
21.05	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
21.05	Consensus	blt_on	Orthosteric Ligand	blt1_on
21.05	Consensus	cck_off	Orthosteric Ligand	ccka_off
21.05	Consensus	ccka_off	Orthosteric Ligand	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
21.05	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
21.05	Consensus	hca3_on	Orthosteric Ligand	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
21.05	Consensus	hcar_off	Orthosteric Ligand	succinate_off
21.05	Consensus	leuko_on	Orthosteric Ligand	blt_on
21.05	Consensus	succinate_off	Orthosteric Ligand	6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
21.05	Consensus	tp_off	Orthosteric Ligand	6IIV-TP-Daltroban 6IIU-TP-Ramatroban
20.83	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
20.83	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
20.83	Single	7QA8	Peptide	7QA8-STE2-Peptide
20.83	Single	7QA8	Peptide	7QA8-STE2-Peptide
20.83	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
20.83	Single	8GHV	PubChem 145964903	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
20.83	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
20.83	Consensus	class-d_off	Orthosteric Ligand	ste2_off
20.83	Consensus	fpr-alx_on	Orthosteric Ligand	fpr1-alx_on fpr2-alx_on
20.83	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
20.83	Consensus	nmur1_on	Orthosteric Ligand	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
20.69	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
20.69	Consensus	go_class-b1	Orthosteric Ligand	go_crf
20.69	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.59	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
20.00	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
20.00	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
20.00	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
20.00	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
20.00	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
20.00	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
20.00	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
20.00	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
20.00	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
20.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/&β;1/&γ;2
20.00	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
20.00	Single	7VFX	fMLF	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
20.00	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
20.00	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.00	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
20.00	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
20.00	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
20.00	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
20.00	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
20.00	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
20.00	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
20.00	Single	8FEG	PRD_002517	8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
20.00	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
20.00	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
20.00	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.00	Consensus	cb2_on	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
20.00	Consensus	ccr2_off_allo	Other Ligand	5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
20.00	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
20.00	Consensus	cx3cr_on	Orthosteric Ligand	cx3cr1_on
20.00	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
20.00	Consensus	gs_endothelin	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
20.00	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
19.44	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
19.44	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
19.35	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
19.35	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
19.23	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
19.23	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
19.23	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
19.23	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
19.23	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
19.23	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
19.23	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
19.23	Consensus	cx3cr1_on	Orthosteric Ligand	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
19.23	Consensus	gi_chemerin	Orthosteric Ligand	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
19.23	Consensus	gi_formylpeptide	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
19.23	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
19.23	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
19.05	Single	5XR8	AM841	5XR8-CB₁-AM841
19.05	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
19.05	Single	7WV9	PubMed 104895	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
19.05	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/&β;1/&γ;2
19.05	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
19.05	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2
19.05	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
19.05	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
19.05	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
19.05	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
19.05	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
19.05	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
19.05	Consensus	cyslt1_off_ortoallo	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
19.05	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
18.75	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
18.75	Single	3OE6	IT1t	3OE6-CXCR4-IT1t
18.75	Single	3OE8	IT1t	3OE8-CXCR4-IT1t
18.75	Single	6ME5	Agomelatine	6ME5-MT₁-Agomelatine
18.75	Single	6ME9	Ramelteon	6ME9-MT₂-Ramelteon
18.75	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
18.75	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
18.75	Single	8J21	Butyric acid	8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
18.75	Single	8J24	Acetic acid	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
18.75	Consensus	ffa3_on	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
18.75	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
18.75	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
18.52	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
18.52	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
18.52	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
18.52	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.52	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
18.52	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.52	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
18.52	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
18.52	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
18.52	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
18.52	Consensus	class-d_on	Orthosteric Ligand	ste2_on
18.52	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
18.52	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.52	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
18.52	Consensus	nmur_on	Orthosteric Ligand	nmur1_on nmur2_on
18.52	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.18	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
18.18	Single	6C1R	PMX53	6C1R-C5a₁-PMX53-Avacopan; Na
18.18	Single	6IIU	Ramatroban	6IIU-TP-Ramatroban
18.18	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2
18.18	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
18.18	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
18.18	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/&β;1/&γ;2
18.18	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2
18.18	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18	Single	8HK2	C3a anaphylatoxin	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2
18.18	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
18.18	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
18.18	Consensus	cannabinoid_on	Orthosteric Ligand	cb1_on cb2_on
18.18	Consensus	cb1_on	Orthosteric Ligand	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
18.18	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
18.18	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
17.86	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
17.86	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
17.86	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
17.86	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86	Single	7KH0	Acyclovir triphosphate	7KH0-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
17.86	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
17.86	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
17.86	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
17.86	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
17.86	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
17.86	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
17.86	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86	Consensus	gs_melanocortin	Orthosteric Ligand	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2
17.86	Consensus	gs_neuromedin	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
17.65	Single	8H8J	Lodoxamide	8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
17.65	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2
17.65	Single	8X2K	5YM	8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
17.65	Consensus	go_adhesion	Orthosteric Ligand	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
17.65	Consensus	go_class-b2	Orthosteric Ligand	go_adhesion
17.65	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
17.39	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
17.39	Single	8GAG	YVF	8GAG-CB₁-YVF-Gi1/&β;1/&γ;2
17.39	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
17.39	Single	8XJO	U46619	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39	Consensus	c5a1_off_ortoallo	Orthosteric Ligand	6C1Q-C5a₁-PMX53-NDT9513727 6C1R-C5a₁-PMX53-Avacopan; Na
17.39	Consensus	cckb_on	Orthosteric Ligand	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
17.39	Consensus	fpa_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39	Consensus	ot_on	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
17.24	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
17.24	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
17.24	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/&β;1/&γ;2
17.24	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
17.24	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
17.24	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
17.24	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
17.24	Consensus	class-d_on	Orthosteric Ligand	ste2_on
17.24	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
17.14	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
16.67	Single	3ODU	IT1t	3ODU-CXCR4-IT1t
16.67	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
16.67	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
16.67	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
16.67	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
16.67	Single	6RNK	NF-56-EJ40	6RNK-Succinate-NF-56-EJ40
16.67	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
16.67	Single	7F8Y	Devazepide	7F8Y-CCK_A-Devazepide
16.67	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
16.67	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
16.67	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
16.67	Single	7T6S	PubChem 24776341	7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
16.67	Single	7TUZ	7alpha,25-dihydroxycholesterol	7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
16.67	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
16.67	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
16.67	Single	7W0O	Elabela	7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
16.67	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
16.67	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
16.67	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
16.67	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67	Single	8J20	Valeric acid	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
16.67	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/&β;1/&γ;2
16.67	Single	8T3S	Butyric acid	8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67	Consensus	class-d_off	Orthosteric Ligand	ste2_off
16.67	Consensus	etb_on	Orthosteric Ligand	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
16.67	Consensus	ffa3_on_allo	Orthosteric Ligand	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
16.67	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
16.67	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67	Consensus	go_vasopressin	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
16.67	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
16.67	Consensus	gs_bombesin	Orthosteric Ligand	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.67	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
16.13	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.13	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
16.13	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
16.13	Single	7VGX	Neuropeptide Y	7VGX-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
16.13	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
16.13	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
16.13	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
16.13	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
16.13	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
16.13	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
16.00	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
16.00	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
16.00	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
16.00	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
16.00	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
16.00	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
16.00	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
16.00	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
16.00	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
16.00	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
16.00	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
16.00	Consensus	sst2_on	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
16.00	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
15.79	Single	6FFI	MMPEP	6FFI-mGlu₅-MMPEP
15.79	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
15.79	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
15.79	Single	6ZA8	RTI-3a	6ZA8-NTS₁-RTI-3a
15.79	Single	7VVO	PTH	7VVO-PTH1-PTH-Gs/&β;1/&γ;2
15.79	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
15.79	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
15.79	Single	7ZBE	11-cis-Retinal	7ZBE-Rhodopsin-11-cis-Retinal
15.79	Single	8GCM	L902688	8GCM-EP₄-L902688-Gi1/&β;1/&γ;2
15.79	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2
15.79	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79	Single	8K2W	AMG487	8K2W-CXCR3-AMG487
15.79	Single	8T3V	DHA	8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
15.79	Consensus	ffa2_on	Orthosteric Ligand	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
15.62	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
15.38	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
15.38	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
15.38	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
15.38	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
15.38	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
15.38	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
15.38	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
15.15	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
15.15	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
15.00	Single	5ZKP	Foropafant (SR27417)	5ZKP-PAF-Foropafant (SR27417)
15.00	Single	6FFH	Fenobam	6FFH-mGlu₅-Fenobam
15.00	Single	6KPF	PubChem 145915889	6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2
15.00	Single	7CFM	P395	7CFM-GPBA-P395-Gs/&β;1/&γ;2
15.00	Single	7PP1	Selatogrel	7PP1-P2Y₁₂-Selatogrel
15.00	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
15.00	Single	8EJC	TAK-875	8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.00	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
15.00	Single	8KFY	ZK-756326	8KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
15.00	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
15.00	Consensus	cb1_on_allo	Orthosteric Ligand	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
15.00	Consensus	ffa1_on	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00	Consensus	ffa_on	Orthosteric Ligand	ffa4_on ffa1_on ffa2_on ffa3_on
15.00	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
15.00	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
15.00	Consensus	p2y12_off	Orthosteric Ligand	4NTJ-P2Y₁₂-AZD1283 7PP1-P2Y₁₂-Selatogrel
15.00	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
15.00	Consensus	prostanoid_off	Orthosteric Ligand	ep_off tp_off dp_off
14.81	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
14.81	Single	7F4D	Alpha-MSH	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
14.81	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1
14.81	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
14.81	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
14.81	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
14.81	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
14.81	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.81	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
14.29	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
14.29	Single	4PHU	Fasiglifam	4PHU-FFA1 (GPR40)-Fasiglifam
14.29	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
14.29	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
14.29	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
14.29	Single	6KPC	PubChem 145915889	6KPC-CB₂-PubChem 145915889
14.29	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
14.29	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
14.29	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
14.29	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
14.29	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
14.29	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
14.29	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
14.29	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
14.29	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
14.29	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29	Single	7Y27	Somatostatin-14	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
14.29	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2
14.29	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
14.29	Single	8WCB	Cyclohexylammonium ion	8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29	Consensus	ep3_on	Orthosteric Ligand	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
14.29	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
14.29	Consensus	ep_off	Orthosteric Ligand	ep4_off
14.29	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
14.29	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
14.29	Consensus	gs_sst	Orthosteric Ligand	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29	Consensus	nmur2_on	Orthosteric Ligand	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
14.29	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
14.29	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
14.29	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
13.79	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
13.79	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
13.79	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
13.79	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
13.79	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
13.64	Single	5TZR	-	5TZR-FFA1 (GPR40)-MK8666
13.64	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
13.64	Single	6Z4Q	SR142948A	6Z4Q-NTS₁-SR142948A
13.64	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
13.64	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
13.64	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
13.64	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
13.64	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
13.64	Single	7XOX	Cholecystokinin-8	7XOX-CCK_B-Cholecystokinin-8-Gq/&β;1/&γ;2
13.64	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2
13.64	Single	8GDB	PGE2	8GDB-EP₄-PGE2-Gs/&β;1/&γ;2
13.64	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
13.64	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/&β;1/&γ;2
13.64	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
13.64	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
13.64	Consensus	cml1_on	Orthosteric Ligand	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
13.64	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
13.64	Consensus	npy_off	Orthosteric Ligand	npy2_off npy1_off
13.51	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
13.33	Single	6FJ3	PTH	6FJ3-PTH1-PTH
13.33	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
13.33	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
13.33	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
13.33	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
13.33	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
13.33	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
13.33	Single	7XKE	Betahydroxyandrosterone	7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
13.33	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
13.33	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
13.33	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
13.33	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
13.33	Consensus	gabab_off	Other Ligand	7C7S-GABA_B1, GABA_B2-CGP54626 7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid 6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
13.33	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
13.04	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
13.04	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
13.04	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
13.04	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
13.04	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
13.04	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
13.04	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
13.04	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/&β;1/&γ;2
13.04	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2
13.04	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
13.04	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/&β;1/&γ;2
13.04	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
13.04	Consensus	gi_prostanoid	Orthosteric Ligand	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2 8GCM-EP₄-L902688-Gi1/&β;1/&γ;2
13.04	Consensus	nts1_off	Orthosteric Ligand	6Z4Q-NTS₁-SR142948A 6Z4S-NTS₁-SR48692
13.04	Consensus	nts_off	Orthosteric Ligand	nts1_off
13.04	Consensus	prostanoid_on	Orthosteric Ligand	ep_on fpa_on
12.90	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
12.90	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
12.90	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
12.90	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
12.90	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
12.90	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
12.82	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
12.50	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
12.50	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
12.50	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
12.50	Single	6TQ9	SB-408124	6TQ9-OX₁-SB-408124
12.50	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
12.50	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
12.50	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2
12.50	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
12.50	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
12.50	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
12.50	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
12.50	Consensus	crf1_on	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
12.50	Consensus	ep4_on	Orthosteric Ligand	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2
12.50	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
12.50	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
12.50	Consensus	gs_lipid	Orthosteric Ligand	gs_ffa gs_prostanoid
12.50	Consensus	gs_prostanoid	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
12.12	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
12.12	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
12.00	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
12.00	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
12.00	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
12.00	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
12.00	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
11.76	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
11.76	Single	7V6A	PubChem 9864275	7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
11.76	Single	8EIT	Doconexent	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.76	Single	8F76	-	8F76-OR51E2-Gs/&β;1/&γ;2
11.76	Single	8JGB	Conorfamide-Tx2	8JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
11.76	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
11.76	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
11.54	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
11.54	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
11.54	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
11.54	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
11.43	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
11.43	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
11.43	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
11.43	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
11.11	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
11.11	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
11.11	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
11.11	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
11.11	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
11.11	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
11.11	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
11.11	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
11.11	Single	7XP6	Strychnine	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
11.11	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/&β;1/&γ;2
11.11	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
11.11	Consensus	class-t_on	Orthosteric Ligand	taste2_on
11.11	Consensus	gs_class-t	Orthosteric Ligand	gs_taste
11.11	Consensus	gs_taste	Orthosteric Ligand	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
11.11	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
11.11	Consensus	sst_off	Orthosteric Ligand	sst2_off
11.11	Consensus	taste2_on	Orthosteric Ligand	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
10.71	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
10.71	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
10.71	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
10.53	Single	5U09	Taranabant	5U09-CB₁-Taranabant
10.53	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
10.53	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
10.53	Single	8HMP	PubChem 69921479	8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
10.53	Single	8U4P	AMD3100	8U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
10.53	Single	8U8F	PML	8U8F-GPR3-PML-Gs/&β;1/&γ;2
10.53	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
10.53	Consensus	smo_on_allo	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.34	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
10.34	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
10.34	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
10.34	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
10.00	Single	6WJC	Muscarinic toxin 7	6WJC-M₁-Atropine-Muscarinic toxin 7
10.00	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
10.00	Single	6ZIN	SR48692	6ZIN-NTS₁-SR48692
10.00	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
10.00	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
10.00	Single	7S8P	MS47134	7S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.00	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
10.00	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
10.00	Single	8HJ5	PubChem 139030531	8HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00	Single	8HQN	9(S)-HODE	8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
10.00	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/&β;1/&γ;2
10.00	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
10.00	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
10.00	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
10.00	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00	Consensus	m1_off_allo	Other Ligand	6WJC-M₁-Atropine-Muscarinic toxin 7
9.76	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
9.68	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
9.68	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
9.68	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
9.68	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
9.68	Consensus	ghrh_on	Orthosteric Ligand	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
9.68	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
9.52	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
9.52	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.52	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
9.52	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.52	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.52	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
9.52	Single	8EJK	TAK-875	8EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.52	Single	8JGG	BAM8-22	8JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
9.52	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
9.38	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
9.38	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
9.38	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
9.38	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
9.38	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
9.09	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
9.09	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
9.09	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
9.09	Single	6Z4S	SR48692	6Z4S-NTS₁-SR48692
9.09	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
9.09	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/&β;1/&γ;2
9.09	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
9.09	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
9.09	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
9.09	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
9.09	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
8.70	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
8.70	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
8.70	Single	5V56	TC114	5V56-SMO-TC114
8.70	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
8.70	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
8.70	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
8.70	Single	7XBD	Galanin	7XBD-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70	Consensus	mglu2_on	Other Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
8.70	Consensus	nts1_on_allo	Orthosteric Ligand	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.57	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
8.57	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
8.33	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
8.33	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
8.33	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
8.33	Single	6OS2	TRV026	6OS2-AT₁-TRV026
8.33	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
8.33	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
8.33	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
8.33	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
8.33	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
8.33	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
8.33	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.33	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
8.33	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
8.33	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
8.33	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
8.33	Consensus	ep_on	Orthosteric Ligand	ep4_on ep2_on ep3_on
8.33	Consensus	galanin_on	Orthosteric Ligand	gal2_on gal1_on
8.11	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
8.11	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
8.00	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
8.00	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
8.00	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/&β;1/&γ;2
8.00	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2
8.00	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
8.00	Consensus	adgrg2_on	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
8.00	Consensus	cyslt2_off	Orthosteric Ligand	6RZ6-CysLT₂-ONO-2570366 6RZ9-CysLT₂-ONO-2770372 6RZ8-CysLT₂-ONO-2080365
8.00	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off
8.00	Consensus	ep2_on	Orthosteric Ligand	7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2
8.00	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
8.00	Consensus	gs_galanin	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.89	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
7.69	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
7.69	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
7.69	Single	8INR	Alpha-MSH	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.69	Single	8SAI	1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine	8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
7.50	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
7.41	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2
7.41	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
7.14	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
7.14	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.90	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Single	6W25	Ca	6W25-MC₄-SHU9119-Ca
6.67	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
6.25	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
6.25	Single	7V68	PubChem 57664406	7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
6.25	Single	8HQM	NPGLY	8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
6.06	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
5.88	Single	7VDM	Substance P	7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
5.88	Single	7XKD	Betahydroxyandrosterone	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.88	Single	7Y14	Beta-alanine	7Y14-MRGPRD-Beta-alanine
5.88	Single	8HVI	NOX-6-7	8HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
5.71	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Single	6LI0	GTPL9804	6LI0-GPR52-GTPL9804
5.56	Single	7S8O	(R)-Zinc-3573	7S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
5.56	Single	7Y12	Beta-alanine	7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
5.56	Consensus	gip_on_allo	Other Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Single	4MQT	LY2119620	4MQT-M₂-Iperoxo-LY2119620
5.26	Single	6U1N	LY2119620	6U1N-M₂-LY2119620-Arrestin2
5.26	Single	7S8N	(R)-Zinc-3573	7S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26	Single	7TRP	LY2033298	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
5.26	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.26	Single	8J6Q	Compound 9n	8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
5.26	Single	8JII	Compound 9n	8JII-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
5.26	Consensus	hca2_on_allo	Other Ligand	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
5.26	Consensus	m4_on_allo	Other Ligand	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.26	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.00	Single	4K5Y	CP-376395	4K5Y-CRF₁-CP-376395
5.00	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
5.00	Single	7T94	PubChem 57664406	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
5.00	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.00	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
5.00	Single	8DWH	Compound-16	8DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
5.00	Single	8HNN	SCH546738	8HNN-CXCR3-SCH546738
5.00	Single	8J6P	Compound 9n	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
5.00	Single	8JHY	Compound 9n	8JHY-HCA₂-Compound 9n-Gi1/&β;1/&γ;2
5.00	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.00	Consensus	m2_on_allo	Other Ligand	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
4.76	Single	7TRQ	VU0467154	7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
4.76	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
4.76	Single	7XJJ	Galanin	7XJJ-GAL₁-Galanin-Go/&β;1/&γ;2
4.76	Single	8IYX	YL-365	8IYX-GPR34-YL-365
4.76	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.76	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
4.76	Consensus	go_galanin	Orthosteric Ligand	7XJJ-GAL₁-Galanin-Go/&β;1/&γ;2
4.65	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.55	Single	4Z9G	CP-376395	4Z9G-CRF₁-CP-376395
4.55	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
4.55	Single	6ORV	TT-OAD2	6ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
4.55	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
4.55	Single	7WQ3	Galanin	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
4.55	Single	8GTI	BMK-C205	8GTI-CRF₁-BMK-C205
4.55	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
4.55	Consensus	gal1_on	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
4.55	Consensus	gi_galanin	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
4.35	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
4.35	Single	8GTG	BMK-I152	8GTG-CRF₁-BMK-I152
4.17	Single	5V57	TC114	5V57-SMO-TC114
4.17	Single	6OS1	TRV026	6OS1-AT₁-TRV026
4.17	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
4.00	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1
4.00	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00	Single	8GTM	BMK-C203	8GTM-CRF₁-BMK-C203
4.00	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
4.00	Consensus	nts_on	Orthosteric Ligand	nts1_on
3.85	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
3.70	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
3.45	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
2.86	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.78	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.78	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.56	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.56	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.33	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F38	R:R:W70	2	1	Yes	Yes	7	5	2	1
R:R:F38	R:R:Y167	13.41	1	Yes	Yes	7	8	2	2
R:R:F38	R:R:V420	5.24	1	Yes	Yes	7	7	2	2
R:R:N64	R:R:P39	3.26	1	Yes	Yes	4	6	2	2
R:R:G67	R:R:P39	2.03	1	No	Yes	4	6	2	2
R:R:P39	R:R:W70	5.4	1	Yes	Yes	6	5	2	1
R:R:P39	R:R:T145	8.74	1	Yes	Yes	6	5	2	1
R:R:N64	R:R:R66	3.62	1	Yes	Yes	4	5	2	1
R:R:G67	R:R:N64	5.09	1	No	Yes	4	4	2	2
R:R:R66	R:R:R69	5.33	1	Yes	Yes	5	8	1	2
R:R:R66	R:R:W70	7	1	Yes	Yes	5	5	1	1
R:R:R66	W:W:W1	4	1	Yes	Yes	5	0	1	0
R:R:R66	W:W:?2	26.55	1	Yes	Yes	5	0	1	2
R:R:G67	R:R:W70	5.63	1	No	Yes	4	5	2	1
R:R:R69	R:R:S417	6.59	1	Yes	Yes	8	6	2	2
R:R:R69	W:W:?2	16.77	1	Yes	Yes	8	0	2	2
R:R:T145	R:R:W70	7.28	1	Yes	Yes	5	5	1	1
R:R:W70	R:R:Y167	3.86	1	Yes	Yes	5	8	1	2
R:R:I416	R:R:W70	12.92	1	Yes	Yes	4	5	1	1
R:R:S417	R:R:W70	3.71	1	Yes	Yes	6	5	2	1
R:R:V420	R:R:W70	2.45	1	Yes	Yes	7	5	2	1
R:R:W70	W:W:W1	4.69	1	Yes	Yes	5	0	1	0
R:R:W70	W:W:?2	14.41	1	Yes	Yes	5	0	1	2
R:R:G146	R:R:T145	3.64	0	No	Yes	5	5	2	1
R:R:T145	R:R:Y167	7.49	1	Yes	Yes	5	8	1	2
R:R:A168	R:R:T145	5.03	1	No	Yes	5	5	1	1
R:R:T145	W:W:W1	6.06	1	Yes	Yes	5	0	1	0
R:R:S147	R:R:Y218	5.09	0	No	Yes	8	7	2	1
R:R:A168	R:R:Y167	2.67	1	No	Yes	5	8	1	2
R:R:I416	R:R:Y167	4.84	1	Yes	Yes	4	8	1	2
R:R:V420	R:R:Y167	8.83	1	Yes	Yes	7	8	2	2
R:R:A168	W:W:W1	5.19	1	No	Yes	5	0	1	0
R:R:D190	R:R:S170	7.36	1	Yes	No	8	7	2	2
R:R:S170	R:R:Y218	2.54	1	No	Yes	7	7	2	1
R:R:D190	R:R:Q193	2.61	1	Yes	Yes	8	9	2	2
R:R:D190	R:R:Y218	9.2	1	Yes	Yes	8	7	2	1
R:R:D190	R:R:F270	3.58	1	Yes	Yes	8	7	2	2
R:R:F270	R:R:Q193	2.34	1	Yes	Yes	7	9	2	2
R:R:Q193	R:R:S296	2.89	1	Yes	Yes	9	8	2	2
R:R:E297	R:R:Q193	5.1	0	No	Yes	8	9	1	2
R:R:D216	R:R:Y218	3.45	1	No	Yes	6	7	2	1
R:R:D216	R:R:D275	2.66	1	No	Yes	6	5	2	2
R:R:G219	R:R:Y218	4.35	0	No	Yes	7	7	2	1
R:R:F270	R:R:Y218	2.06	1	Yes	Yes	7	7	2	1
R:R:S296	R:R:Y218	6.36	1	Yes	Yes	8	7	2	1
R:R:A298	R:R:Y218	4	1	No	Yes	6	7	1	1
R:R:Y218	W:W:W1	1.93	1	Yes	Yes	7	0	1	0
R:R:F270	R:R:S296	5.28	1	Yes	Yes	7	8	2	2
R:R:G273	R:R:S272	1.86	0	No	No	4	5	2	1
R:R:D275	R:R:S272	7.36	1	Yes	No	5	5	2	1
R:R:S272	W:W:W1	3.71	0	No	Yes	5	0	1	0
R:R:E297	R:R:L322	10.6	0	No	Yes	8	4	1	2
R:R:E297	W:W:W1	5.45	0	No	Yes	8	0	1	0
R:R:A298	W:W:W1	5.19	1	No	Yes	6	0	1	0
R:R:L322	R:R:N419	4.12	1	Yes	Yes	4	7	2	2
R:R:I416	R:R:N419	2.83	1	Yes	Yes	4	7	1	2
R:R:I416	W:W:W1	5.87	1	Yes	Yes	4	0	1	0
R:R:I416	W:W:?2	9.85	1	Yes	Yes	4	0	1	2
R:R:S417	W:W:?2	5.18	1	Yes	Yes	6	0	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
100.00	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
100.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
100.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
100.00	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
100.00	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
100.00	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
100.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
100.00	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
100.00	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
100.00	Single	7DD5	Ca3	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
100.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
100.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
100.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
100.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
100.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00	Single	7EB2	Baclofen	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
100.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
100.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
100.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
100.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
100.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
100.00	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00	Single	7FII	hCG	7FII-LH-hCG-6fuf
100.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
100.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
100.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
100.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
100.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
100.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
100.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
100.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
100.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
100.00	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
100.00	Single	7XW7	K1-70	7XW7-TSH-K1-70
100.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
100.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
100.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
100.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
100.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
100.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
100.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
100.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
100.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
100.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
100.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
100.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
100.00	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-J9R
100.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
100.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
100.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
100.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
100.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
100.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
100.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
100.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
100.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
100.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
100.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
100.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
100.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
100.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
100.00	Consensus	fsh_on_allo	Orthosteric Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
100.00	Consensus	gabab_off	Orthosteric Ligand	7C7S-GABA_B1, GABA_B2-CGP54626 7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid 6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
100.00	Consensus	gabab_on	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
100.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
100.00	Consensus	gi_gaba	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	gphr_on	Orthosteric Ligand	lh_on tsh_on
100.00	Consensus	gs_gphr	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00	Consensus	gs_protein	Orthosteric Ligand	gs_gphr
100.00	Consensus	lh_on	Orthosteric Ligand	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00	Consensus	lh_on_allo	Orthosteric Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
100.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
100.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
100.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
100.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
100.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
100.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
100.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
100.00	Consensus	smo_off_allo	Other Ligand	6D32-SMO-Cyclopamine-Cyclopamine
100.00	Consensus	tsh_on	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2
100.00	Consensus	tsh_on_allo	Orthosteric Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
50.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
33.33	Single	8HS2	Fab046	8HS2-GPR20-Fab046
25.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
25.00	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00	Single	7UTZ	TR1402	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
25.00	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
25.00	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
20.00	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
20.00	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/&β;1/&γ;2
20.00	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
20.00	Single	8I2G	Glycoprotein hormones alpha chain	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
14.29	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
14.29	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
14.29	Single	6LI0	GTPL9804	6LI0-GPR52-GTPL9804
14.29	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
14.29	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
14.29	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
12.50	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
12.50	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
12.50	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
12.50	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50	Consensus	go_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.50	Consensus	go_protein	Orthosteric Ligand	go_chemokine
12.50	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
11.11	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
11.11	Single	5U09	Taranabant	5U09-CB₁-Taranabant
11.11	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.11	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
11.11	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
11.11	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
11.11	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
11.11	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
11.11	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
11.11	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
11.11	Single	8HMP	PubChem 69921479	8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Consensus	class-f_off	Orthosteric Ligand	smo_off
11.11	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
11.11	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
11.11	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
10.00	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
10.00	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
10.00	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.00	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
10.00	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
10.00	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
10.00	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
10.00	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
10.00	Consensus	gi_class-f	Orthosteric Ligand	gi_frizzled
10.00	Consensus	gi_frizzled	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
10.00	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
10.00	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
9.09	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
9.09	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
9.09	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
9.09	Single	6D27	CAY10471	6D27-DP₂-CAY10471
9.09	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.09	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
9.09	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
9.09	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
9.09	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
9.09	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
9.09	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
9.09	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
9.09	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
9.09	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.09	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
9.09	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
9.09	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.33	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
8.33	Single	5C1M	BU72	5C1M-μ-BU72
8.33	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.33	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.33	Single	7C4S	S1P	7C4S-S1P₃-S1P
8.33	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
8.33	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
8.33	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.33	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
8.33	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
8.33	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
8.33	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.69	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
7.69	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
7.69	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
7.69	Single	5V56	TC114	5V56-SMO-TC114
7.69	Single	5V57	TC114	5V57-SMO-TC114
7.69	Single	6OS1	TRV026	6OS1-AT₁-TRV026
7.69	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
7.69	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.69	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
7.69	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
7.69	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.69	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.69	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.69	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
7.69	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
7.69	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
7.69	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Single	8E0G	BU72	8E0G-μ-BU72
7.69	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
7.69	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
7.69	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.69	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
7.69	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
7.69	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
7.69	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.69	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
7.14	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
7.14	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
7.14	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
7.14	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
7.14	Single	6OS2	TRV026	6OS2-AT₁-TRV026
7.14	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.14	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
7.14	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
7.14	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.14	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
7.14	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
7.14	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.14	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
7.14	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
7.14	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
7.14	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
7.14	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
7.14	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
7.14	Consensus	dp_off	Orthosteric Ligand	dp2_off
7.14	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
7.14	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
7.14	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.14	Consensus	nts_on	Orthosteric Ligand	nts1_on
7.14	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
7.14	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.67	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
6.67	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
6.67	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
6.67	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
6.67	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
6.67	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
6.67	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6.67	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
6.67	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
6.67	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
6.67	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.67	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.67	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
6.25	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
6.25	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
6.25	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
6.25	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
6.25	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
6.25	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
6.25	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
6.25	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
6.25	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
6.25	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
6.25	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
6.25	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
5.88	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
5.88	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.88	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.88	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
5.88	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
5.88	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
5.88	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.88	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
5.88	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.88	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.88	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.88	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
5.88	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.88	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.88	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.88	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
5.88	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
5.56	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
5.56	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.56	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
5.56	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
5.56	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
5.56	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
5.56	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
5.56	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.56	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
5.56	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.56	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.56	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
5.56	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
5.26	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
5.26	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
5.26	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
5.26	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
5.26	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
5.26	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.26	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
5.26	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
5.26	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.26	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
5.26	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
5.26	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
5.26	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
5.26	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
5.00	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
5.00	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
5.00	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
5.00	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
5.00	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.00	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
5.00	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
5.00	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
5.00	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
5.00	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
5.00	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
5.00	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
5.00	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
5.00	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.00	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
5.00	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
5.00	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.76	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.76	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
4.76	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.76	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.76	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.76	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.76	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.76	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.76	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.76	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.76	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
4.76	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
4.76	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.76	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
4.76	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
4.55	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
4.55	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
4.55	Single	6FJ3	PTH	6FJ3-PTH1-PTH
4.55	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.55	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.55	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
4.55	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
4.55	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
4.55	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.55	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
4.55	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
4.55	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.55	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.55	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
4.55	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.55	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.35	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
4.35	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
4.35	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
4.35	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.35	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
4.35	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
4.35	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
4.35	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.35	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.35	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.35	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
4.35	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.35	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
4.35	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
4.35	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.35	Consensus	go_class-b1	Orthosteric Ligand	go_crf
4.35	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.35	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.17	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
4.17	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
4.17	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.17	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
4.17	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.17	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
4.17	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.17	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
4.17	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
4.17	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
4.17	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
4.17	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
4.17	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
4.17	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.17	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.17	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.17	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
4.17	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
4.17	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
4.17	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.00	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
4.00	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.00	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
4.00	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
4.00	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.00	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
4.00	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.00	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
4.00	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
4.00	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.00	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
4.00	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.00	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
3.85	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.85	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
3.85	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.85	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.85	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.85	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.85	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
3.85	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
3.70	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
3.70	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.70	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.70	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.70	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.70	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
3.57	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.57	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.57	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.57	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.57	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.57	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.57	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.57	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.57	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
3.57	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.45	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.45	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.45	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
3.45	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
3.33	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.33	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.23	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.23	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
3.23	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.12	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
3.12	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
3.12	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.03	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
3.03	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
3.03	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.94	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.94	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.86	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I822	S:S:F612	2.51	9	Yes	Yes	7	8	1	2
R:R:P823	S:S:F612	5.78	9	Yes	Yes	9	8	2	2
R:R:C661	R:R:F684	5.59	0	No	Yes	7	8	2	1
R:R:F684	R:R:S664	5.28	9	Yes	No	8	6	1	2
R:R:E837	R:R:F668	9.33	9	Yes	Yes	9	9	1	2
R:R:F668	R:R:I841	3.77	0	Yes	Yes	9	9	2	1
R:R:Q681	R:R:W742	6.57	9	Yes	Yes	9	9	1	2
R:R:L773	R:R:Q681	13.31	9	No	Yes	8	9	1	1
R:R:E837	R:R:Q681	2.55	9	Yes	Yes	9	9	1	1
R:R:Q681	W:W:?4	6.95	9	Yes	Yes	9	0	1	0
R:R:F684	R:R:G685	3.01	9	Yes	No	8	8	1	1
R:R:F684	R:R:F688	7.5	9	Yes	Yes	8	8	1	2
R:R:F684	R:R:W818	3.01	9	Yes	Yes	8	9	1	1
R:R:F684	R:R:I841	17.58	9	Yes	Yes	8	9	1	1
R:R:F684	W:W:?4	19.07	9	Yes	Yes	8	0	1	0
R:R:G685	W:W:?4	2.55	9	No	Yes	8	0	1	0
R:R:F688	R:R:T780	2.59	0	Yes	No	8	7	2	1
R:R:F688	R:R:F814	13.93	0	Yes	Yes	8	9	2	1
R:R:L776	R:R:Q735	10.65	0	No	Yes	8	9	1	2
R:R:Q735	R:R:T780	5.67	52	Yes	No	9	7	2	1
R:R:I738	R:R:L776	4.28	0	No	No	8	8	2	1
R:R:I777	R:R:L773	4.28	9	No	No	8	8	1	1
R:R:L773	W:W:?4	2.06	9	No	Yes	8	0	1	0
R:R:L776	W:W:?4	4.13	0	No	Yes	8	0	1	0
R:R:G778	R:R:I777	3.53	0	No	No	5	8	2	1
R:R:I777	W:W:?4	17.02	9	No	Yes	8	0	1	0
R:R:T780	W:W:?4	6.59	0	No	Yes	7	0	1	0
R:R:A784	R:R:F814	2.77	9	No	Yes	8	9	2	1
R:R:A784	R:R:F815	4.16	9	No	Yes	8	7	2	2
R:R:F814	R:R:F815	10.72	9	Yes	Yes	9	7	1	2
R:R:F814	R:R:W818	8.02	9	Yes	Yes	9	9	1	1
R:R:A844	R:R:F814	2.77	9	No	Yes	9	9	2	1
R:R:F814	W:W:?4	3.63	9	Yes	Yes	9	0	1	0
R:R:A840	R:R:W818	7.78	0	No	Yes	9	9	2	1
R:R:I841	R:R:W818	2.35	9	Yes	Yes	9	9	1	1
R:R:A844	R:R:W818	2.59	9	No	Yes	9	9	2	1
R:R:W818	W:W:?4	33.96	9	Yes	Yes	9	0	1	0
R:R:I822	R:R:P823	3.39	9	Yes	Yes	7	9	1	2
R:R:I822	W:W:?4	4.26	9	Yes	Yes	7	0	1	0
R:R:E837	R:R:Y825	2.24	9	Yes	No	9	9	1	1
R:R:Y825	W:W:?4	11.36	9	No	Yes	9	0	1	0
R:R:E837	W:W:?4	11.85	9	Yes	Yes	9	0	1	0
R:R:I841	W:W:?4	2.13	9	Yes	Yes	9	0	1	0
R:R:I819	R:R:I822	1.47	0	No	Yes	6	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
92.31	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
84.62	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
76.92	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
69.23	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
69.23	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
69.23	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
69.23	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
69.23	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
66.67	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
66.67	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
62.50	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
61.54	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
60.00	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
60.00	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
58.82	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
58.82	Consensus	opioid_off	Orthosteric Ligand	kop_off mop_off nop_off dop_off
57.14	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
57.14	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
57.14	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
57.14	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
57.14	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
56.25	Single	5X7D	(S)-Carazolol	5X7D-β₂-(S)-Carazolol-PubChem 129318963
56.25	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
56.25	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/&β;1/&γ;2
56.25	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
56.25	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
56.25	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
55.00	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
53.33	Single	8THL	Epinephrine	8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.33	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
52.94	Single	5X93	K-8794	5X93-ET_B-K-8794
52.94	Single	8IRU	Rotigotine	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
52.94	Single	8JD0	J9R	8JD0-mGlu2; mGlu3-Glutamate-J9R
52.94	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
52.94	Consensus	5ht_off	Orthosteric Ligand	5ht2_off 5ht5_off 5ht1_off
52.63	Single	3NY9	PubChem 913103	3NY9-β₂-PubChem 913103
50.00	Single	1HZX	11-cis-Retinal	1HZX-Rhodopsin-11-cis-Retinal
50.00	Single	3NY8	ICI 118-551	3NY8-β₂-ICI 118-551
50.00	Single	3ZPR	4-methyl-2-(piperazin-1-yl)	3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
50.00	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
50.00	Single	4GBR	(S)-Carazolol	4GBR-β₂-(S)-Carazolol
50.00	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
50.00	Single	5JQH	(S)-Carazolol	5JQH-β₂-(S)-Carazolol
50.00	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
50.00	Single	6PS0	(S)-Carazolol	6PS0-β₂-(S)-Carazolol
50.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
50.00	Consensus	alpha2_on	Orthosteric Ligand	alpha2a_on alpha2b_on
50.00	Consensus	alpha_on	Orthosteric Ligand	alpha1_on alpha2_on
50.00	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
47.62	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
47.62	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
47.37	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
47.37	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
47.37	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
47.37	Single	8E9Y	PubChem 446603	8E9Y-M₃-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.37	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
47.37	Consensus	beta1_off_allo	Orthosteric Ligand	4BVN-β₁-Cyanopindolol-Na
47.37	Consensus	endothelin_off	Orthosteric Ligand	etb_off
47.37	Consensus	etb_off	Orthosteric Ligand	5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500 5X93-ET_B-K-8794
47.06	Single	2RH1	(S)-Carazolol	2RH1-β₂-(S)-Carazolol
47.06	Single	2YCW	(S)-Carazolol	2YCW-β₁-(S)-Carazolol
47.06	Single	5D6L	(S)-Carazolol	5D6L-β₂-(S)-Carazolol
47.06	Single	5XPR	Bosentan	5XPR-ET_B-Bosentan
47.06	Single	6PS6	Timolol	6PS6-β₂-Timolol
47.06	Single	7WC6	LSD	7WC6-5-HT_2A-LSD
47.06	Single	8DZR	GR89,696	8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
47.06	Consensus	alpha2a_on	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
47.06	Consensus	amine_off	Orthosteric Ligand	adrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
47.06	Consensus	beta2_off	Orthosteric Ligand	6PS2-β₂-(S)-Alprenolol 6PS3-β₂-(S)-Carvedilol 6PS5-β₂-(S)-Propranolol 6PS6-β₂-Timolol 2RH1-β₂-(S)-Carazolol 6PS4-β₂-ICI 118-551 3NY9-β₂-PubChem 913103
47.06	Consensus	beta_off	Orthosteric Ligand	beta1_off beta2_off
47.06	Consensus	go_amine	Orthosteric Ligand	go_adrenergic go_muscarinic go_5ht
46.67	Single	2PED	9-cis-Retinal	2PED-Rhodopsin-9-cis-Retinal
46.67	Single	6B73	PubChem 131955138	6B73-κ-PubChem 131955138
46.67	Single	7EJ0	L-Norepinephrine	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2
46.67	Single	8EFO	PZM21	8EFO-μ-PZM21-Gi1/&β;1/&γ;2
46.67	Consensus	alpha1_on	Orthosteric Ligand	alpha1a_on
46.67	Consensus	alpha1a_on	Orthosteric Ligand	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67	Consensus	mglu_on	Other Ligand	mglu2_on mglu4_on
45.00	Single	6PT3	DPI-287	6PT3-δ-DPI-287
45.00	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
44.44	Single	2YDV	NECA	2YDV-A_2A-NECA
44.44	Single	4DJH	JDTic	4DJH-κ-JDTic
44.44	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
44.44	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
44.44	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
44.44	Single	5D5A	(S)-Carazolol	5D5A-β₂-(S)-Carazolol
44.44	Single	5D5B	(S)-Carazolol	5D5B-β₂-(S)-Carazolol
44.44	Single	5G53	NECA	5G53-A_2A-NECA-Gs
44.44	Single	5V54	Methiothepin	5V54-5-HT_1B-Methiothepin
44.44	Single	5ZKB	AF-DX 384	5ZKB-M₂-AF-DX 384
44.44	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
44.44	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
44.44	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
44.44	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
44.44	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
44.44	Single	7EPE	NAM563	7EPE-mGlu-NAM563
44.44	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2
44.44	Single	7U2L	PubChem 163201242	7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
44.44	Single	7W6P	W96	7W6P-α_2a-W96-Go/&β;1/&γ;2
44.44	Single	7W7E	W58	7W7E-α_2a-W58-Go/&β;1/&γ;2
44.44	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/&β;1/&γ;2
44.44	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/&β;1/&γ;2
44.44	Single	8E0G	BU72	8E0G-μ-BU72
44.44	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2
44.44	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
44.44	Single	8JXX	Clobenpropit	8JXX-H₄-Clobenpropit-Gi1/&β;1/&γ;2
44.44	Consensus	5ht1_off	Orthosteric Ligand	5ht1b_off
44.44	Consensus	5ht1b_off	Orthosteric Ligand	5V54-5-HT_1B-Methiothepin
44.44	Consensus	a2_on	Orthosteric Ligand	a2a_on a2b_on
44.44	Consensus	beta1_off	Orthosteric Ligand	2VT4-β₁-Cyanopindolol 2YCZ-β₁-Iodocyanopindolol
44.44	Consensus	dopamine_off	Orthosteric Ligand	d3_off d2_off d4_off
44.44	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
44.44	Consensus	go_adrenergic	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
44.44	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2
44.44	Consensus	h1_off	Orthosteric Ligand	3RZE-H₁-Cidoxepin 8X5Y-H₁-Astemizole 8X63-H₁-Mepyramine 8X64-H₁-Desloratadine
44.44	Consensus	histamine_off	Orthosteric Ligand	h1_off
44.44	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
44.44	Consensus	muscarinic_off	Orthosteric Ligand	m2_off m3_off m4_off m5_off m1_off
43.75	Single	3OAX	11-cis-Retinal	3OAX-Rhodopsin-11-cis-Retinal
43.75	Single	3UZC	PubChem 135566609	3UZC-A_2A-PubChem 135566609
43.75	Single	4DKL	Beta-funaltrexamine	4DKL-μ-Beta-funaltrexamine
43.75	Single	4LDO	L-Epinephrine	4LDO-β₂-L-Epinephrine
43.75	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
43.75	Single	6K41	Dexmedetomidine	6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2
43.75	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
43.75	Single	6PS4	ICI 118-551	6PS4-β₂-ICI 118-551
43.75	Single	6TPG	EMPA	6TPG-OX₂-EMPA
43.75	Single	6TPN	HTL6641	6TPN-OX₂-HTL6641
43.75	Single	7CMU	Pramipexole	7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
43.75	Single	7E33	BRL-54443	7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2
43.75	Single	7RAN	PubChem 164575847	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75	Single	7ZBC	11-cis-Retinal	7ZBC-Rhodopsin-11-cis-Retinal
43.75	Single	8FCZ	11-cis-Retinal	8FCZ-Rhodopsin-11-cis-Retinal
43.75	Single	8GEG	Epinephrine	8GEG-β₂-Epinephrine-Gs/&β;1/&γ;2
43.75	Single	8GGQ	Epinephrine	8GGQ-β₂-Epinephrine
43.75	Single	8THK	A61603	8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75	Single	8UNZ	Epinephrine	8UNZ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75	Consensus	5ht1e_on	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2
43.75	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6WH4-5-HT_2A-Methiothepin 7VOE-5-HT_2A-Aripiprazole 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 6A93-5-HT_2A-Risperidone
43.75	Consensus	alpha2b_on	Orthosteric Ligand	6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2
43.75	Consensus	d3_on	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
43.75	Consensus	dop_off_allo	Orthosteric Ligand	4N6H-δ-Naltrindole-Na
42.86	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
42.86	Consensus	mop_off	Orthosteric Ligand	7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
42.11	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
42.11	Single	3D4S	Timolol Maleate	3D4S-β₂-Timolol Maleate
42.11	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
42.11	Single	4LDE	BI167107	4LDE-β₂-BI167107
42.11	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
42.11	Single	5CXV	Tiotropium	5CXV-M₁-Tiotropium
42.11	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
42.11	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
42.11	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
42.11	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
42.11	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.11	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
42.11	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
42.11	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
42.11	Consensus	m1_off	Orthosteric Ligand	5CXV-M₁-Tiotropium
42.11	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
41.18	Single	2VT4	Cyanopindolol	2VT4-β₁-Cyanopindolol
41.18	Single	2Y04	Salbutamol	2Y04-β₁-Salbutamol
41.18	Single	2YCY	Cyanopindolol	2YCY-β₁-Cyanopindolol
41.18	Single	3NYA	(S)-Alprenolol	3NYA-β₂-(S)-Alprenolol
41.18	Single	3ZPQ	4-(piperazin-1- yl)-1H-indole	3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na
41.18	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
41.18	Single	4U16	N-Methyl Scopolamine	4U16-M₃-N-Methyl Scopolamine
41.18	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
41.18	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
41.18	Single	6K42	Dexmedetomidine	6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
41.18	Single	6PRZ	(S)-Alprenolol	6PRZ-β₂-(S)-Alprenolol
41.18	Single	6PS2	(S)-Alprenolol	6PS2-β₂-(S)-Alprenolol
41.18	Single	7BTS	L-Epinephrine	7BTS-β₁-L-Epinephrine
41.18	Single	7BU6	L-Norepinephrine	7BU6-β₁-L-Norepinephrine
41.18	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/&β;1/&γ;2
41.18	Single	7E32	Serotonin	7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2
41.18	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
41.18	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
41.18	Single	7S0G	Isoprenaline	7S0G-β₁-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
41.18	Single	7UM5	5-CT	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
41.18	Single	7XTC	5-CT	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
41.18	Single	8CIC	Etrumadenant	8CIC-A_2A-Etrumadenant-Na
41.18	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
41.18	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
41.18	Single	8GE3	Epinephrine	8GE3-β₂-Epinephrine-Gs/&β;1/&γ;2
41.18	Single	8GEE	Epinephrine	8GEE-β₂-Epinephrine-Gs/&β;1/&γ;2
41.18	Single	8GEH	Epinephrine	8GEH-β₂-Epinephrine-Gs/&β;1/&γ;2
41.18	Single	8GFW	Epinephrine	8GFW-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18	Single	8GFX	Epinephrine	8GFX-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18	Single	8GFY	Epinephrine	8GFY-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18	Single	8GFZ	Epinephrine	8GFZ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18	Single	8GG0	Epinephrine	8GG0-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18	Single	8GG1	Epinephrine	8GG1-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18	Single	8GG2	Epinephrine	8GG2-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18	Single	8GG6	Epinephrine	8GG6-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18	Single	8GGJ	Epinephrine	8GGJ-β₂-Epinephrine
41.18	Single	8GGN	Epinephrine	8GGN-β₂-Epinephrine
41.18	Single	8GGO	Epinephrine	8GGO-β₂-Epinephrine
41.18	Single	8GGU	Epinephrine	8GGU-β₂-Epinephrine
41.18	Single	8IRT	Rotigotine	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2
41.18	Single	8JJO	Alprenolol	8JJO-β₂-Alprenolol
41.18	Single	8JLJ	T1AM	8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
41.18	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
41.18	Single	8UNN	Epinephrine	8UNN-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18	Single	8UNP	Epinephrine	8UNP-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
41.18	Single	8X64	Desloratadine	8X64-H₁-Desloratadine
41.18	Consensus	5ht1d_on	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2
41.18	Consensus	5ht7_on	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
41.18	Consensus	adrenergic_on	Orthosteric Ligand	beta_on alpha_on
41.18	Consensus	amine_on	Orthosteric Ligand	adrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
41.18	Consensus	dopamine_on	Orthosteric Ligand	d3_on d2_on d5_on d1_on
41.18	Consensus	tar_on	Orthosteric Ligand	ta1_on
40.00	Single	1U19	11-cis-Retinal	1U19-Rhodopsin-11-cis-Retinal
40.00	Single	2G87	All-trans-retinal	2G87-Rhodopsin-All-trans-retinal
40.00	Single	2I35	11-cis-Retinal	2I35-Rhodopsin-11-cis-Retinal
40.00	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
40.00	Single	3AYM	All-trans-retinal	3AYM-Rhodopsin-All-trans-retinal
40.00	Single	3PBL	Eticlopride	3PBL-D₃-Eticlopride
40.00	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
40.00	Single	6QNO	All-trans-retinal	6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
40.00	Single	7EJK	Oxymetazoline	7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2
40.00	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
40.00	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
40.00	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
40.00	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2
40.00	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
40.00	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
40.00	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
40.00	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00	Single	8WC3	SEP-363856	8WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
40.00	Consensus	5ht5a_off	Orthosteric Ligand	7UM4-5-HT_5A-AS2674723
40.00	Consensus	d3_off	Orthosteric Ligand	3PBL-D₃-Eticlopride
40.00	Consensus	ffa4_on_allo	Orthosteric Ligand	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00	Consensus	ox1_off_allo	Orthosteric Ligand	6TOD-OX₁-EMPA-Na 6TOS-OX₁-GSK1059865-Na 6TQ4-OX₁-PubChem 16046844-Na 6TO7-OX₁-Suvorexant-Na
39.13	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
38.89	Single	2Y03	Isoprenaline	2Y03-β₁-Isoprenaline
38.89	Single	5C1M	BU72	5C1M-μ-BU72
38.89	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
38.89	Single	5TVN	LSD	5TVN-5-HT_2B-LSD
38.89	Single	5WQC	EMPA	5WQC-OX₂-EMPA
38.89	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
38.89	Single	6PS3	(S)-Carvedilol	6PS3-β₂-(S)-Carvedilol
38.89	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
38.89	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
38.89	Single	7BVQ	(S)-Carazolol	7BVQ-β₁-(S)-Carazolol
38.89	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2
38.89	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
38.89	Single	7XKA	Epinephrine	7XKA-β₂-Epinephrine
38.89	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
38.89	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/&β;1/&γ;2
38.89	Single	8E9Z	Iperoxo	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89	Single	8EFB	Oliceridine	8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
38.89	Single	8UNY	Epinephrine	8UNY-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89	Consensus	5ht1_on	Orthosteric Ligand	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
38.89	Consensus	adrenergic_off	Orthosteric Ligand	beta_off alpha_off
38.89	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
38.89	Consensus	beta2_on	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2
38.89	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
38.89	Consensus	gi_adrenergic	Orthosteric Ligand	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
38.89	Consensus	go_opioid	Orthosteric Ligand	8DZQ-κ-momSalB-Go/&β;1/&γ;2
38.89	Consensus	m2_off	Orthosteric Ligand	5ZKB-M₂-AF-DX 384 5ZKC-M₂-N-Methyl Scopolamine 5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
38.89	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
38.46	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
38.10	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
38.10	Single	7XY6	PubChem 11717831	7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
38.10	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
38.10	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
38.10	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
37.50	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
37.50	Single	1GZM	11-cis-Retinal	1GZM-Rhodopsin-11-cis-Retinal
37.50	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
37.50	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
37.50	Single	3C9L	11-cis-Retinal	3C9L-Rhodopsin-11-cis-Retinal
37.50	Single	5WS3	EMPA	5WS3-OX₂-EMPA
37.50	Single	6KUX	RS-79948	6KUX-α_2a-RS-79948
37.50	Single	6KUY	PubChem 145704643	6KUY-α_2a-PubChem 145704643
37.50	Single	6TOD	EMPA	6TOD-OX₁-EMPA-Na
37.50	Single	6TQ6	PubChem 145714283	6TQ6-OX₁-PubChem 145714283
37.50	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
37.50	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
37.50	Single	7DHR	Isoprenaline	7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2
37.50	Single	7F24	Dopamine	7F24-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
37.50	Single	7YM8	Oxymetazoline	7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
37.50	Single	7YMH	Norepinephrine	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
37.50	Single	8A6C	All-trans-retinal	8A6C-Rhodopsin-All-trans-retinal
37.50	Single	8A6D	All-trans-retinal	8A6D-Rhodopsin-All-trans-retinal
37.50	Single	8A6E	All-trans-retinal	8A6E-Rhodopsin-All-trans-retinal
37.50	Single	8GEC	Epinephrine	8GEC-β₂-Epinephrine-Gs/&β;1/&γ;2
37.50	Single	8GEF	Epinephrine	8GEF-β₂-Epinephrine-Gs/&β;1/&γ;2
37.50	Single	8GG9	Epinephrine	8GG9-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50	Single	8GGA	Epinephrine	8GGA-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50	Single	8GGF	Epinephrine	8GGF-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50	Single	8GGV	Epinephrine	8GGV-β₂-Epinephrine
37.50	Single	8GGX	Epinephrine	8GGX-β₂-Epinephrine
37.50	Single	8GH0	Epinephrine	8GH0-β₂-Epinephrine
37.50	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50	Single	8UNW	Epinephrine	8UNW-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50	Single	8UO0	Epinephrine	8UO0-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
37.50	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
37.50	Consensus	5ht2_on	Orthosteric Ligand	5ht2a_on 5ht2c_on
37.50	Consensus	alpha2_off	Orthosteric Ligand	alpha2a_off alpha2c_off
37.50	Consensus	alpha2a_off	Orthosteric Ligand	6KUX-α_2a-RS-79948
37.50	Consensus	gs_5ht	Orthosteric Ligand	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50	Consensus	opsin_off	Orthosteric Ligand	1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
36.84	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/&β;1/&γ;2
36.84	Single	3UON	Quinuclidinyl benzilate hydrobromide	3UON-M₂-Quinuclidinyl benzilate hydrobromide
36.84	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
36.84	Single	4U15	Tiotropium	4U15-M₃-Tiotropium
36.84	Single	6E59	L-760735	6E59-NK₁-L-760735
36.84	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
36.84	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/&β;1/&γ;2
36.84	Single	6OL9	Tiotropium	6OL9-M₅-Tiotropium
36.84	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
36.84	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
36.84	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/&β;1/&γ;2
36.84	Single	7EW4	CYM5541	7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2
36.84	Single	7EW7	PubChem 4077460	7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
36.84	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/&β;1/&γ;2
36.84	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/&β;1/&γ;2
36.84	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
36.84	Single	8EF5	Fentanyl	8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
36.84	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2
36.84	Consensus	5ht5_off	Orthosteric Ligand	5ht5a_off
36.84	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
36.84	Consensus	gi_dopamine	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
36.84	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A_2A-NECA-Gs/&β;1/&γ;1 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
36.84	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
36.84	Consensus	m3_off	Orthosteric Ligand	4U15-M₃-Tiotropium 4U16-M₃-N-Methyl Scopolamine 5ZHP-M₃-PubChem 134828589
36.84	Consensus	m5_off	Orthosteric Ligand	6OL9-M₅-Tiotropium
36.84	Consensus	nk1_off	Orthosteric Ligand	6J20-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
36.84	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
36.36	Single	4AMJ	(S)-Carvedilol	4AMJ-β₁-(S)-Carvedilol
36.36	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
36.36	Single	8G59	TUG-891	8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
35.71	Single	2HPY	All-trans-retinal	2HPY-Rhodopsin-All-trans-retinal
35.71	Single	6OY9	All-trans-retinal	6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
35.71	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
35.29	Single	4ZJC	SB-674042	4ZJC-OX₁-SB-674042
35.29	Single	5TE3	Octyl Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
35.29	Single	6A94	Zotepine	6A94-5-HT_2A-Zotepine
35.29	Single	6IQL	L745870	6IQL-D₄-L745870
35.29	Single	6PS5	(S)-Propranolol	6PS5-β₂-(S)-Propranolol
35.29	Single	6TOS	GSK1059865	6TOS-OX₁-GSK1059865-Na
35.29	Single	6VI4	JDTic	6VI4-κ-JDTic
35.29	Single	6WH4	Methiothepin	6WH4-5-HT_2A-Methiothepin
35.29	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/&β;1/&γ;2
35.29	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
35.29	Single	7CMV	PD128907	7CMV-D₃-PD128907-Gi1/&β;1/&γ;2
35.29	Single	7DHI	Salbutamol	7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2
35.29	Single	7EJ8	Brimonidine	7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2
35.29	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2
35.29	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/&β;1/&γ;2
35.29	Single	7SR8	TAK-925	7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.29	Single	7UM7	Methylergometrine	7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
35.29	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
35.29	Single	8GE1	Epinephrine	8GE1-β₂-Epinephrine-Gs/&β;1/&γ;2
35.29	Single	8GE4	Epinephrine	8GE4-β₂-Epinephrine-Gs/&β;1/&γ;2
35.29	Single	8GE6	Epinephrine	8GE6-β₂-Epinephrine-Gs/&β;1/&γ;2
35.29	Single	8GE7	Epinephrine	8GE7-β₂-Epinephrine-Gs/&β;1/&γ;2
35.29	Single	8GE8	Epinephrine	8GE8-β₂-Epinephrine-Gs/&β;1/&γ;2
35.29	Single	8GE9	Epinephrine	8GE9-β₂-Epinephrine-Gs/&β;1/&γ;2
35.29	Single	8GFV	Epinephrine	8GFV-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29	Single	8GG3	Epinephrine	8GG3-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29	Single	8GG4	Epinephrine	8GG4-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29	Single	8GG5	Epinephrine	8GG5-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29	Single	8GGI	Epinephrine	8GGI-β₂-Epinephrine
35.29	Single	8GGK	Epinephrine	8GGK-β₂-Epinephrine
35.29	Single	8GGM	Epinephrine	8GGM-β₂-Epinephrine
35.29	Single	8GGP	Epinephrine	8GGP-β₂-Epinephrine
35.29	Single	8GGT	Epinephrine	8GGT-β₂-Epinephrine
35.29	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
35.29	Single	8JLN	T1AM	8JLN-TA1-T1AM-Gs/&β;1/&γ;2
35.29	Single	8UNQ	Epinephrine	8UNQ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29	Single	8UNR	Epinephrine	8UNR-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29	Single	8UNS	Epinephrine	8UNS-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29	Single	8UO2	Epinephrine	8UO2-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2
35.29	Consensus	5ht2a_on	Orthosteric Ligand	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29	Consensus	5ht5_on	Orthosteric Ligand	5ht5a_on
35.29	Consensus	5ht5a_on	Orthosteric Ligand	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
35.29	Consensus	d1_on_allo	Orthosteric Ligand	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
35.29	Consensus	gs_tar	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
35.29	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
35.29	Consensus	ox1_off	Orthosteric Ligand	6TOT-OX₁-Lemborexant 6TP4-OX₁-ACT-462206 6TP6-OX₁-Filorexant 6V9S-OX₁-GTPL11403 6TP3-OX₁-Nemorexant 6TQ6-OX₁-PubChem 145714283 6TQ7-OX₁-SB-334867 6TQ9-OX₁-SB-408124 4ZJC-OX₁-SB-674042 4ZJ8-OX₁-Suvorexant
35.29	Consensus	ox2_off	Orthosteric Ligand	6TPN-OX₂-HTL6641 7XRR-OX₂-Lemborexant
35.29	Consensus	sensory_off	Orthosteric Ligand	opsin_off
35.00	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
35.00	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
35.00	Single	6H7N	(S)-Xamoterol	6H7N-β₁-(S)-Xamoterol
35.00	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
35.00	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2
35.00	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
35.00	Single	7JNI	Olodanrigan	7JNI-AT₂-Olodanrigan
35.00	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
35.00	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
35.00	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
35.00	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
35.00	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
35.00	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
35.00	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
35.00	Consensus	at2_off	Orthosteric Ligand	7JNI-AT₂-Olodanrigan
35.00	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
35.00	Consensus	go_5ht	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
35.00	Consensus	leuko_off	Orthosteric Ligand	blt_off cyslt_off
35.00	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
35.00	Consensus	peptide_off	Orthosteric Ligand	opioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
34.78	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
34.78	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
34.78	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
34.78	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
33.33	Single	2Y01	Dobutamine	2Y01-β₁-Dobutamine
33.33	Single	2Y02	Carmoterol	2Y02-β₁-Carmoterol
33.33	Single	3C9M	11-cis-Retinal	3C9M-Rhodopsin-11-cis-Retinal
33.33	Single	3PQR	All-trans-retinal	3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
33.33	Single	3UZA	GTPL9236	3UZA-A_2A-GTPL9236
33.33	Single	4DAJ	Tiotropium	4DAJ-M₃-Tiotropium
33.33	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
33.33	Single	4X1H	Nonyl Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
33.33	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
33.33	Single	5DHG	PubChem 25001412	5DHG-NOP-PubChem 25001412
33.33	Single	5DSG	Tiotropium	5DSG-M₄-Tiotropium
33.33	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
33.33	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
33.33	Single	5YC8	N-Methyl Scopolamine	5YC8-M₂-N-Methyl Scopolamine
33.33	Single	5ZK8	N-Methyl Scopolamine	5ZK8-M₂-N-Methyl Scopolamine
33.33	Single	5ZKC	N-Methyl Scopolamine	5ZKC-M₂-N-Methyl Scopolamine
33.33	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/&β;1/&γ;2
33.33	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
33.33	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
33.33	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
33.33	Single	6H7M	Salbutamol	6H7M-β₁-Salbutamol
33.33	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
33.33	Single	6PS1	Timolol	6PS1-β₂-Timolol
33.33	Single	6TOT	Lemborexant	6TOT-OX₁-Lemborexant
33.33	Single	6WHA	DB13948	6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33	Single	7BU7	BI167107	7BU7-β₁-BI167107
33.33	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
33.33	Single	7LJC	PubChem 86764103	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
33.33	Single	7MT8	All-trans-retinal	7MT8-Rhodopsin-All-trans-retinal-GRK1
33.33	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
33.33	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
33.33	Single	7SQO	TAK-925	7SQO-OX₂-TAK-925-Gi1/&β;1/&γ;2
33.33	Single	7T2G	Mitragynine pseudoindoxyl	7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
33.33	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
33.33	Single	7UL4	Alvimopan	7UL4-μ-Alvimopan
33.33	Single	7UM6	Lisuride	7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
33.33	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
33.33	Single	7WC7	Lisuride	7WC7-5-HT_2A-Lisuride
33.33	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
33.33	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
33.33	Single	7XJH	Isoproterenol	7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
33.33	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/&β;1/&γ;2
33.33	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/&β;1/&γ;2
33.33	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2
33.33	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
33.33	Single	8GEB	Epinephrine	8GEB-β₂-Epinephrine-Gs/&β;1/&γ;2
33.33	Single	8GGB	Epinephrine	8GGB-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
33.33	Single	8IU2	Retinal	8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
33.33	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
33.33	Single	8POK	Histamine	8POK-H₂-Histamine-Gs/&β;1/&γ;2
33.33	Single	8UNM	Epinephrine	8UNM-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33	Single	8UO4	Epinephrine	8UO4-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
33.33	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
33.33	Single	8WC7	ZH8667	8WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
33.33	Single	8WC9	ZH8651	8WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33	Single	8WRZ	8D0	8WRZ-CB₁-8D0-Arrestin1
33.33	Single	8X63	Mepyramine	8X63-H₁-Mepyramine
33.33	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
33.33	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on
33.33	Consensus	d5_on	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
33.33	Consensus	gi_5ht	Orthosteric Ligand	7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT_5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2
33.33	Consensus	go_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
33.33	Consensus	gq_amine	Orthosteric Ligand	gq_muscarinic gq_histamine
33.33	Consensus	histamine_on	Orthosteric Ligand	h1_on h4_on
33.33	Consensus	m4_off	Orthosteric Ligand	5DSG-M₄-Tiotropium
33.33	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on
33.33	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
33.33	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
33.33	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
32.00	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
32.00	Consensus	class-d_on	Orthosteric Ligand	ste2_on
32.00	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
32.00	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
31.82	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
31.82	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
31.82	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
31.82	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
31.82	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
31.82	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
31.58	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
31.58	Single	4WW3	All-trans-retinal	4WW3-Rhodopsin-All-trans-retinal
31.58	Single	4ZJ8	Suvorexant	4ZJ8-OX₁-Suvorexant
31.58	Single	5NM2	ZM241385	5NM2-A_2A-ZM241385-Na
31.58	Single	5ZK3	Quinuclidinyl benzilate hydrobromide	5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
31.58	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/&β;1/&γ;2
31.58	Single	6E67	BI167107	6E67-β₂-BI167107-Gs (fused)
31.58	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
31.58	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
31.58	Single	6OIK	Iperoxo	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
31.58	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
31.58	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
31.58	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/&β;1/&γ;2
31.58	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
31.58	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
31.58	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
31.58	Single	8EA0	Iperoxo	8EA0-M₃-Iperoxo
31.58	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
31.58	Single	8QOT	Nanobody E	8QOT-μ-Nanobody E
31.58	Consensus	a1_on_allo	Orthosteric Ligand	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
31.58	Consensus	a2a_on	Orthosteric Ligand	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
31.58	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
31.58	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
31.58	Consensus	gq_muscarinic	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
31.58	Consensus	gs_adrenergic	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJI-β₃-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
31.58	Consensus	gs_muscarinic	Orthosteric Ligand	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58	Consensus	m1_on	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
31.58	Consensus	m3_on	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25	Single	1L9H	11-cis-Retinal	1L9H-Rhodopsin-11-cis-Retinal
31.25	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
31.25	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
31.25	Single	6HLL	CP99994	6HLL-NK₁-CP99994
31.25	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
31.25	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
31.25	Single	6TP4	ACT-462206	6TP4-OX₁-ACT-462206
31.25	Single	6TQ4	PubChem 16046844	6TQ4-OX₁-PubChem 16046844-Na
31.25	Single	7E2Y	Serotonin	7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2
31.25	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2
31.25	Single	7XTB	Serotonin	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2
31.25	Single	7YFD	Imetit	7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25	Single	8DPF	Lorcaserin	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25	Single	8EF6	Morphine	8EF6-μ-Morphine-Gi1/&β;1/&γ;2
31.25	Single	8GEI	Epinephrine	8GEI-β₂-Epinephrine-Gs/&β;1/&γ;2
31.25	Single	8GGC	Epinephrine	8GGC-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25	Single	8GGE	Epinephrine	8GGE-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25	Single	8GGS	Epinephrine	8GGS-β₂-Epinephrine
31.25	Single	8GGY	Epinephrine	8GGY-β₂-Epinephrine
31.25	Single	8GH1	Epinephrine	8GH1-β₂-Epinephrine
31.25	Single	8HN8	Histamine	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2
31.25	Single	8ITF	DMCHA	8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
31.25	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
31.25	Single	8UNV	Epinephrine	8UNV-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25	Single	8UNX	Epinephrine	8UNX-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
31.25	Single	8W8B	SEP-363856	8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2
31.03	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
30.77	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
30.77	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
30.43	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
30.43	Single	7QA8	Peptide	7QA8-STE2-Peptide
30.43	Single	7QA8	Peptide	7QA8-STE2-Peptide
30.43	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
30.43	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
30.43	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/&β;1/&γ;2
30.43	Consensus	class-d_off	Orthosteric Ligand	ste2_off
30.00	Single	3P0G	BI167107	3P0G-β₂-BI167107
30.00	Single	3PDS	Hydroxybenzylisoproterenol	3PDS-β₂-Hydroxybenzylisoproterenol
30.00	Single	4LDL	Hydroxybenzylisoproterenol	4LDL-β₂-Hydroxybenzylisoproterenol
30.00	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
30.00	Single	5XRA	AM11542	5XRA-CB₁-AM11542
30.00	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
30.00	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
30.00	Single	6OIJ	Iperoxo	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
30.00	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2
30.00	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
30.00	Single	7FEE	PubMed 104895	7FEE-CB₁-PubMed 104895-ZCZ011
30.00	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
30.00	Single	7TRQ	Iperoxo	7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
30.00	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2
30.00	Single	7W41	PD176252	7W41-BB₂-PD176252
30.00	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
30.00	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/&β;1/&γ;2
30.00	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
30.00	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
30.00	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
30.00	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/&β;1/&γ;2
30.00	Single	8X16	Piclidenoson	8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
30.00	Consensus	5ht1b_on	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
30.00	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
30.00	Consensus	angiotensin_off	Orthosteric Ligand	at1_off at2_off
30.00	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
30.00	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
30.00	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
30.00	Consensus	ffa4_on	Orthosteric Ligand	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
30.00	Consensus	gi_ffa	Orthosteric Ligand	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
30.00	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
30.00	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
30.00	Consensus	sst4_on	Orthosteric Ligand	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
29.63	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
29.63	Consensus	class-d_on	Orthosteric Ligand	ste2_on
29.63	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
29.41	Single	2X72	All-trans-retinal	2X72-Rhodopsin-All-trans-retinal-Gt(CT)
29.41	Single	3VGA	ZM241385	3VGA-A_2A-ZM241385-Antibody
29.41	Single	4S0V	Suvorexant	4S0V-OX₂-Suvorexant
29.41	Single	5DHH	SB-612111	5DHH-NOP-SB-612111
29.41	Single	6AKX	A4R	6AKX-CCR5-A4R
29.41	Single	6NWE	Octyl Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
29.41	Single	6OBA	(S)-Alprenolol	6OBA-β₂-(S)-Alprenolol-GTPL11074
29.41	Single	6TPJ	Suvorexant	6TPJ-OX₂-Suvorexant
29.41	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
29.41	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
29.41	Single	7LJD	Dopamine	7LJD-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;1
29.41	Single	7SRS	LSD	7SRS-5-HT_2B-LSD-Arrestin2
29.41	Single	7T8X	Acetylcholine	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
29.41	Single	7T90	Acetylcholine	7T90-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
29.41	Single	7X2F	Dopamine	7X2F-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
29.41	Single	7X5H	5-CT	7X5H-5-HT_5A-5-CT-Gi1/&β;1/&γ;2
29.41	Single	7XRR	Lemborexant	7XRR-OX₂-Lemborexant
29.41	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
29.41	Single	8GEA	Epinephrine	8GEA-β₂-Epinephrine-Gs/&β;1/&γ;2
29.41	Single	8GED	Epinephrine	8GED-β₂-Epinephrine-Gs/&β;1/&γ;2
29.41	Single	8GG7	Epinephrine	8GG7-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41	Single	8GGW	Epinephrine	8GGW-β₂-Epinephrine
29.41	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2
29.41	Single	8HOC	Imetit	8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
29.41	Single	8UNL	Epinephrine	8UNL-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41	Single	8UNO	Epinephrine	8UNO-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41	Single	8UNT	Epinephrine	8UNT-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41	Single	8UNU	Epinephrine	8UNU-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41	Single	8UO3	Epinephrine	8UO3-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
29.41	Consensus	5ht2c_on	Orthosteric Ligand	8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41	Consensus	5ht_on	Orthosteric Ligand	5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
29.41	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
29.41	Consensus	a2a_off_allo	Orthosteric Ligand	6ZDR-A_2A-HMS1413f12-Na 6GT3-A_2A-Imaradenant-Na 8CU7-A_2A-LJ-4517-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PubChem 92460631; psb36-Na 5MZJ-A_2A-Theophylline-Na 5OLO-A_2A-Tozadenant-Na 5OLH-A_2A-Vipadenant-Na 5NM4-A_2A-ZM241385-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5MZP-A_2A-Caffeine-Na 8CIC-A_2A-Etrumadenant-Na
29.41	Consensus	beta2_off_allo	Orthosteric Ligand	6OBA-β₂-(S)-Alprenolol-GTPL11074
29.41	Consensus	gi_histamine	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2 8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
29.41	Consensus	gi_nucleotide	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
29.41	Consensus	gs_histamine	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41	Consensus	h4_on	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41	Consensus	m2_on	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
29.41	Consensus	orexin_off	Orthosteric Ligand	ox2_off ox1_off
29.17	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
29.17	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
29.17	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
28.57	Single	3PXO	All-trans-retinal	3PXO-Rhodopsin-All-trans-retinal
28.57	Single	5DYS	All-trans-retinal	5DYS-Rhodopsin-All-trans-retinal
28.57	Single	6DRY	Methylergonovine	6DRY-5-HT_2B-Methylergonovine
28.57	Single	6KQI	PubMed 104895	6KQI-CB₁-PubMed 104895-ORG27569
28.57	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
28.57	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
28.57	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
28.57	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
28.57	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
28.57	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
28.57	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
28.57	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
28.57	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
28.57	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
28.57	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
28.57	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
28.57	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
28.57	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/&β;1/&γ;2
28.57	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
28.57	Single	8JWY	PubChem 168451710	8JWY-A_2A-PubChem 168451710
28.57	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
28.57	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/&β;1/&γ;2
28.57	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57	Single	8WU1	KCA	8WU1-CB₁-KCA-Arrestin1
28.57	Consensus	beta1_on	Orthosteric Ligand	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
28.57	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
28.57	Consensus	cb1_off_allo	Orthosteric Ligand	6KQI-CB₁-PubMed 104895-ORG27569
28.57	Consensus	class-c_on	Other Ligand	gabab_on mglu_on
28.57	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
28.57	Consensus	gi_class-f	Other Ligand	gi_frizzled
28.57	Consensus	gi_frizzled	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
28.57	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
28.57	Consensus	gpr119_on	Orthosteric Ligand	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
28.57	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
28.00	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
28.00	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
28.00	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
28.00	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
27.78	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
27.78	Single	3RZE	Cidoxepin	3RZE-H₁-Cidoxepin
27.78	Single	4MBS	Maraviroc	4MBS-CCR5-Maraviroc
27.78	Single	4MQT	Iperoxo	4MQT-M₂-Iperoxo-LY2119620
27.78	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
27.78	Single	5JTB	ZM241385	5JTB-A_2A-ZM241385
27.78	Single	6AQF	ZM241385	6AQF-A_2A-ZM241385
27.78	Single	6DS0	Ly266097	6DS0-5-HT_2B-Ly266097
27.78	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
27.78	Single	6TP3	Nemorexant	6TP3-OX₁-Nemorexant
27.78	Single	6TPK	Retosiban	6TPK-OT-Retosiban
27.78	Single	6V9S	GTPL11403	6V9S-OX₁-GTPL11403
27.78	Single	6WJC	Atropine	6WJC-M₁-Atropine-Muscarinic toxin 7
27.78	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
27.78	Single	6ZG9	GSK1034702	6ZG9-M₁-GSK1034702
27.78	Single	7EJA	Dexmedetomidine	7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
27.78	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
27.78	Single	7T94	Acetylcholine	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
27.78	Single	7TRS	Acetylcholine	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2
27.78	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
27.78	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
27.78	Single	7ZBE	11-cis-Retinal	7ZBE-Rhodopsin-11-cis-Retinal
27.78	Single	8DPG	Psilocin	8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78	Single	8GDZ	Epinephrine	8GDZ-β₂-Epinephrine-Gs/&β;1/&γ;2
27.78	Single	8GG8	Epinephrine	8GG8-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78	Single	8GGL	Epinephrine	8GGL-β₂-Epinephrine
27.78	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2
27.78	Single	8GUR	PubChem 104895	8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2
27.78	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
27.78	Single	8JSP	Ulotaront	8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2
27.78	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/&β;1/&γ;2
27.78	Consensus	at1_off	Orthosteric Ligand	4YAY-AT₁-ZD-7155 4ZUD-AT₁-Olmesartan
27.78	Consensus	ghrelin_off	Orthosteric Ligand	6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
27.78	Consensus	m1_off_allo	Orthosteric Ligand	6WJC-M₁-Atropine-Muscarinic toxin 7
27.78	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
27.78	Consensus	vasopressin-ot_off	Orthosteric Ligand	ot_off
27.59	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
27.59	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
27.27	Single	5UNG	PubChem 15780052	5UNG-AT₂-PubChem 15780052
27.27	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
27.27	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
27.27	Single	7EZC	UKA	7EZC-A_2A-UKA
27.27	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
27.27	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
27.27	Single	8GAG	YVF	8GAG-CB₁-YVF-Gi1/&β;1/&γ;2
27.27	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2
27.27	Single	8ID8	TUG-891	8ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
27.27	Consensus	bileacid_on	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
27.27	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
27.27	Consensus	gs_orexin	Orthosteric Ligand	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
27.27	Consensus	orexin_on	Orthosteric Ligand	ox2_on
27.27	Consensus	steroid_on	Orthosteric Ligand	bileacid_on
26.92	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
26.92	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2
26.92	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/&β;1/&γ;2
26.67	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
26.67	Single	7MTB	All-trans-retinal	7MTB-Rhodopsin-All-trans-retinal-GRK1
26.67	Single	8DPH	Lorcaserin	8DPH-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.67	Single	8IWM	2-Phenylethylamine	8IWM-TAAR9-2-Phenylethylamine
26.67	Single	8WC5	Tetramethylammonium ion	8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
26.67	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
26.67	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
26.67	Consensus	gs_crf	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
26.67	Consensus	sensory_on	Orthosteric Ligand	opsin_on
26.32	Single	3EML	ZM241385	3EML-A_2A-ZM241385
26.32	Single	4EIY	ZM241385	4EIY-A_2A-ZM241385-Na
26.32	Single	4MQS	Iperoxo	4MQS-M₂-Iperoxo
26.32	Single	4QKX	PubChem 76210628	4QKX-β₂-PubChem 76210628
26.32	Single	4U14	Tiotropium	4U14-M₃-Tiotropium
26.32	Single	4YAY	ZD-7155	4YAY-AT₁-ZD-7155
26.32	Single	4ZUD	Olmesartan	4ZUD-AT₁-Olmesartan
26.32	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
26.32	Single	5K2A	ZM241385	5K2A-A_2A-ZM241385-Na
26.32	Single	5OLG	ZM241385	5OLG-A_2A-ZM241385-Na
26.32	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
26.32	Single	5UIG	J3.651.884G	5UIG-A_2A-J3.651.884G
26.32	Single	5VRA	ZM241385	5VRA-A_2A-ZM241385-Na
26.32	Single	5ZKP	Foropafant (SR27417)	5ZKP-PAF-Foropafant (SR27417)
26.32	Single	6DRX	Lisuride	6DRX-5-HT_2B-Lisuride
26.32	Single	6DRZ	Methysergide	6DRZ-5-HT_2B-Methysergide
26.32	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
26.32	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
26.32	Single	6GPS	MK0812	6GPS-CCR2-MK0812
26.32	Single	6KPF	PubChem 145915889	6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2
26.32	Single	6S0L	ZM241385	6S0L-A_2A-ZM241385
26.32	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
26.32	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
26.32	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/&β;1/&γ;2
26.32	Single	7TRP	Iperoxo	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
26.32	Single	7V3Z	PubMed 104895	7V3Z-CB₁-PubMed 104895
26.32	Single	7VH0	Ramelteon	7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
26.32	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
26.32	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
26.32	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
26.32	Single	8J18	(3R)-3-hydroxydodecanoic acid	8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
26.32	Single	8X17	Namodenoson	8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
26.32	Consensus	5ht1a_on	Orthosteric Ligand	8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2
26.32	Consensus	a2_off	Orthosteric Ligand	a2a_off
26.32	Consensus	a2a_off	Orthosteric Ligand	8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 5UIG-A_2A-J3.651.884G 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-PubChem 168451710 5K2D-A_2A-ZM241385
26.32	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
26.32	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
26.32	Consensus	blt_on	Orthosteric Ligand	blt1_on
26.32	Consensus	gi_hca	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
26.32	Consensus	gi_hcar	Orthosteric Ligand	gi_hca
26.32	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
26.32	Consensus	hca2_on	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA₂-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
26.32	Consensus	leuko_on	Orthosteric Ligand	blt_on
26.32	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
26.32	Consensus	m2_on_allo	Orthosteric Ligand	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
26.32	Consensus	m4_on_allo	Orthosteric Ligand	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
26.32	Consensus	muscarinic_on	Orthosteric Ligand	m2_on m3_on m4_on m1_on
26.09	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
26.09	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
26.09	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
26.09	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/&β;1/&γ;2
26.09	Consensus	class-d_off	Orthosteric Ligand	ste2_off
26.09	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
26.09	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.93	Single	7KH0	Acyclovir triphosphate	7KH0-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.00	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
25.00	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
25.00	Single	5CGC	HTL14242	5CGC-mGlu₅-HTL14242
25.00	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
25.00	Single	5N2S	PSB36	5N2S-A₁-PSB36
25.00	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
25.00	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
25.00	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
25.00	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
25.00	Single	6FUF	All-trans-retinal	6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
25.00	Single	6GPX	MK0812	6GPX-CCR2-MK0812
25.00	Single	6LPL	ZM241385	6LPL-A_2A-ZM241385-Na
25.00	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
25.00	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
25.00	Single	6S0Q	ZM241385	6S0Q-A_2A-ZM241385
25.00	Single	6WQA	ZM241385	6WQA-A_2A-ZM241385-Na
25.00	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
25.00	Single	7C4S	S1P	7C4S-S1P₃-S1P
25.00	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2
25.00	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
25.00	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
25.00	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
25.00	Single	7MT9	All-trans-retinal	7MT9-Rhodopsin-All-trans-retinal-GRK1
25.00	Single	7MTA	All-trans-retinal	7MTA-Rhodopsin-All-trans-retinal-GRK1
25.00	Single	7RM5	ZM241385	7RM5-A_2A-ZM241385-Na
25.00	Single	7TRK	Iperoxo	7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2
25.00	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
25.00	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
25.00	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
25.00	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
25.00	Single	8DPI	Lorcaserin	8DPI-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00	Single	8FYN	ZM241385	8FYN-A_2A-ZM241385-Na
25.00	Single	8GGR	Epinephrine	8GGR-β₂-Epinephrine
25.00	Single	8GGZ	Epinephrine	8GGZ-β₂-Epinephrine
25.00	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
25.00	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
25.00	Single	8IW7	2-Phenylethylamine	8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00	Single	8J19	PubChem 127045422	8J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
25.00	Single	8J21	Butyric acid	8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
25.00	Single	8J24	Acetic acid	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
25.00	Single	8J6Q	Beta-hydroxybutyrate	8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
25.00	Single	8JXT	Histamine	8JXT-H₄-Histamine-PO4-Gi1/&β;1/&γ;2
25.00	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
25.00	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
25.00	Consensus	5ht2b_off	Orthosteric Ligand	6DRZ-5-HT_2B-Methysergide 6DRX-5-HT_2B-Lisuride
25.00	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
25.00	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
25.00	Consensus	cb2_on	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
25.00	Consensus	d4_off	Orthosteric Ligand	5WIU-D₄-Nemonapride
25.00	Consensus	d4_off_allo	Orthosteric Ligand	5WIV-D₄-Nemonapride-Na
25.00	Consensus	ffa3_on	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
25.00	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
25.00	Consensus	opsin_on	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
25.00	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
24.14	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
24.14	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
24.14	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
24.14	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
24.14	Consensus	go_class-b1	Orthosteric Ligand	go_crf
24.14	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
24.00	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/&β;1/&γ;2
24.00	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
24.00	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
24.00	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
24.00	Consensus	cx3cr_on	Orthosteric Ligand	cx3cr1_on
23.81	Single	4IAQ	Dihydroergotamine	4IAQ-5-HT_1B-Dihydroergotamine
23.81	Single	5XR8	AM841	5XR8-CB₁-AM841
23.81	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
23.81	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
23.81	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
23.81	Single	7P2L	4YI	7P2L-mGlu₅-4YI
23.81	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
23.81	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
23.81	Single	7WV9	PubMed 104895	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
23.81	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/&β;1/&γ;2
23.81	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2
23.81	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
23.81	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
23.81	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
23.81	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/&β;1/&γ;2
23.81	Single	8TAO	CDPPB	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
23.81	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
23.81	Consensus	alpha1b_off	Orthosteric Ligand	7B6W-α_1b-Cyclazosin
23.81	Consensus	gs_compl-peptide	Orthosteric Ligand	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81	Consensus	gs_ffa	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2 8GDB-EP₄-PGE2-Gs/&β;1/&γ;2
23.81	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
23.81	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
23.81	Consensus	npy_off	Orthosteric Ligand	npy2_off npy1_off
23.81	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
23.81	Consensus	s1p2_on	Orthosteric Ligand	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
23.53	Single	5OLV	LUAA41063	5OLV-A_2A-LUAA41063-Na
23.53	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
23.53	Single	6I9K	9-cis-Retinal	6I9K-Rhodopsin-9-cis-Retinal
23.53	Single	7DFL	Histamine	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
23.53	Single	7SRQ	LSD	7SRQ-5-HT_2B-LSD
23.53	Single	7V68	Iperoxo	7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
23.53	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/&β;1/&γ;2
23.53	Single	7YFC	Histamine	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53	Single	7YS6	Serotonin	7YS6-5-HT₆-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
23.53	Single	8A2P	LUAA47070	8A2P-A_2A-LUAA47070-Na
23.53	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
23.53	Single	8X2K	5YM	8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
23.53	Consensus	5ht4_on	Orthosteric Ligand	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
23.53	Consensus	gq_histamine	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
23.53	Consensus	h1_on	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
23.33	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
23.33	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
23.33	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
23.33	Single	8FEG	PRD_002517	8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
23.33	Consensus	gs_endothelin	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.08	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
23.08	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1
23.08	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
23.08	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
23.08	Consensus	cx3cr1_on	Orthosteric Ligand	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
22.73	Single	5X33	BIIL260	5X33-BLT₁-BIIL260
22.73	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2
22.73	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
22.73	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
22.73	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
22.73	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.73	Single	8I95	EP54	8I95-C3a_B-EP54-Go/&β;1/&γ;2
22.73	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg3_on
22.73	Consensus	blt1_off	Orthosteric Ligand	7K15-BLT₁-MKD046-Na
22.73	Consensus	blt_off	Orthosteric Ligand	blt1_off
22.73	Consensus	cannabinoid_on	Orthosteric Ligand	cb1_on cb2_on
22.73	Consensus	cb1_on	Orthosteric Ligand	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
22.73	Consensus	class-b2_on	Orthosteric Ligand	adgrg_on
22.73	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
22.73	Consensus	gs_bileacid	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
22.73	Consensus	gs_steroid	Orthosteric Ligand	gs_bileacid
22.73	Consensus	gs_trh	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.73	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.58	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
22.58	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
22.58	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
22.58	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
22.22	Single	5K2D	ZM241385	5K2D-A_2A-ZM241385
22.22	Single	5OLH	Vipadenant	5OLH-A_2A-Vipadenant-Na
22.22	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
22.22	Single	6AKY	Maraviroc	6AKY-CCR5-Maraviroc
22.22	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/&β;1/&γ;2
22.22	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
22.22	Single	6JZH	ZM241385	6JZH-A_2A-ZM241385-Na
22.22	Single	6OYA	All-trans-retinal	6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
22.22	Single	6PS7	ZM241385	6PS7-A_2A-ZM241385-Na
22.22	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
22.22	Single	7F8U	Lintitript	7F8U-CCK_A-Lintitript
22.22	Single	7SRR	LSD	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22	Single	7T6S	PubChem 24776341	7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
22.22	Single	7TUZ	7alpha,25-dihydroxycholesterol	7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
22.22	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
22.22	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
22.22	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
22.22	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
22.22	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
22.22	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
22.22	Single	8IW4	Spermidine	8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
22.22	Single	8IWE	Spermidine	8IWE-TAAR9-Spermidine
22.22	Single	8J20	Valeric acid	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
22.22	Single	8T3S	Butyric acid	8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22	Single	8UO1	Epinephrine	8UO1-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
22.22	Consensus	ffa3_on_allo	Orthosteric Ligand	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
22.22	Consensus	gi_somatostatin	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
22.22	Consensus	gt_class-a	Orthosteric Ligand	gt_opsin
22.22	Consensus	gt_opsin	Orthosteric Ligand	gt_sensory
22.22	Consensus	gt_sensory	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
22.22	Consensus	melatonin_on	Orthosteric Ligand	mt1_on mt2_on
22.22	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
21.88	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
21.88	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
21.88	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
21.74	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
21.74	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
21.74	Single	5CGD	HTL14242	5CGD-mGlu₅-HTL14242
21.74	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
21.74	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
21.74	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
21.43	Single	4A4M	All-trans-retinal	4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
21.43	Single	5EN0	All-trans-retinal	5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
21.43	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
21.43	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
21.43	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
21.43	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
21.43	Consensus	bombesin_on	Orthosteric Ligand	bb2_on bb1_on
21.43	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
21.21	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
21.05	Single	3REY	PubChem 5697	3REY-A_2A-PubChem 5697
21.05	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
21.05	Single	5IU4	ZM241385	5IU4-A_2A-ZM241385-Na
21.05	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
21.05	Single	5K2B	ZM241385	5K2B-A_2A-ZM241385-Na
21.05	Single	5K2C	ZM241385	5K2C-A_2A-ZM241385-Na
21.05	Single	5NLX	ZM241385	5NLX-A_2A-ZM241385-Na
21.05	Single	5NM4	ZM241385	5NM4-A_2A-ZM241385-Na
21.05	Single	5UVI	ZM241385	5UVI-A_2A-ZM241385
21.05	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
21.05	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
21.05	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
21.05	Single	6MH8	ZM241385	6MH8-A_2A-ZM241385
21.05	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
21.05	Single	6ZDV	PubChem 984073	6ZDV-A_2A-PubChem 984073-Na
21.05	Single	6ZFZ	77-LH-28-1	6ZFZ-M₁-77-LH-28-1
21.05	Single	7ARO	LUF5833	7ARO-A_2A-LUF5833-Na
21.05	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
21.05	Single	7T32	ZM241385	7T32-A_2A-ZM241385
21.05	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
21.05	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
21.05	Single	8HNM	VUF11222	8HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
21.05	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
21.05	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/&β;1/&γ;2
21.05	Single	8JIM	MMF	8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2
21.05	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/&β;1/&γ;2
21.05	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
21.05	Single	8T3V	DHA	8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05	Consensus	ffa2_on	Orthosteric Ligand	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
21.05	Consensus	gi_melatonin	Orthosteric Ligand	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
21.05	Consensus	hca_on	Orthosteric Ligand	hca2_on hca3_on
21.05	Consensus	hcar_on	Orthosteric Ligand	hca_on
21.05	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
21.05	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
20.83	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
20.83	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
20.83	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
20.83	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
20.83	Consensus	go_vasopressin	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.83	Consensus	gs_adgr	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
20.83	Consensus	gs_class-b2	Orthosteric Ligand	gs_adgr
20.83	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
20.83	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
20.69	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
20.69	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69	Consensus	bb1_on	Orthosteric Ligand	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69	Consensus	gi_neuromedin	Orthosteric Ligand	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
20.69	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.69	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
20.00	Single	5UEN	DU172	5UEN-A₁-DU172
20.00	Single	6IIV	Daltroban	6IIV-TP-Daltroban
20.00	Single	6LPJ	ZM241385	6LPJ-A_2A-ZM241385-Na
20.00	Single	6LPK	ZM241385	6LPK-A_2A-ZM241385-Na
20.00	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
20.00	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
20.00	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
20.00	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
20.00	Single	6Z10	PubChem 154585554	6Z10-Succinate-PubChem 154585554
20.00	Single	7CFM	P395	7CFM-GPBA-P395-Gs/&β;1/&γ;2
20.00	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
20.00	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
20.00	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
20.00	Single	7NA8	PubChem 178024	7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
20.00	Single	7PP1	Selatogrel	7PP1-P2Y₁₂-Selatogrel
20.00	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
20.00	Single	7T6V	fMLFII	7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
20.00	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/&β;1/&γ;2
20.00	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
20.00	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
20.00	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
20.00	Single	7YAC	Paltusotine	7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
20.00	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
20.00	Single	8EJK	TAK-875	8EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
20.00	Single	8GEJ	Epinephrine	8GEJ-β₂-Epinephrine-Gs/&β;1/&γ;2
20.00	Single	8GHV	PubChem 145964903	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
20.00	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/&β;1/&γ;2
20.00	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/&β;1/&γ;2
20.00	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
20.00	Single	8JII	Niacin	8JII-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
20.00	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
20.00	Single	8KFY	ZK-756326	8KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
20.00	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
20.00	Consensus	cb1_on_allo	Orthosteric Ligand	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
20.00	Consensus	cck_off	Orthosteric Ligand	ccka_off
20.00	Consensus	ccka_off	Orthosteric Ligand	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
20.00	Consensus	etb_on	Orthosteric Ligand	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
20.00	Consensus	ffa_on	Orthosteric Ligand	ffa4_on ffa1_on ffa2_on ffa3_on
20.00	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
20.00	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
20.00	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
20.00	Consensus	hca3_on	Orthosteric Ligand	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
20.00	Consensus	hcar_off	Orthosteric Ligand	succinate_off
20.00	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
20.00	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
20.00	Consensus	p2y12_off	Orthosteric Ligand	4NTJ-P2Y₁₂-AZD1283 7PP1-P2Y₁₂-Selatogrel
20.00	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
20.00	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
20.00	Consensus	sst_on	Orthosteric Ligand	sst2_on sst4_on
20.00	Consensus	succinate_off	Orthosteric Ligand	6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
20.00	Consensus	tp_off	Orthosteric Ligand	6IIV-TP-Daltroban 6IIU-TP-Ramatroban
19.35	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
19.35	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
19.35	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
19.35	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
19.35	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
19.23	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
19.23	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
19.23	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
19.23	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off alpha1b_off
19.23	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
19.05	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
19.05	Single	5N2R	PubChem 92460631; psb36	5N2R-A_2A-PubChem 92460631; psb36-Na
19.05	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
19.05	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
19.05	Single	6KPC	PubChem 145915889	6KPC-CB₂-PubChem 145915889
19.05	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
19.05	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
19.05	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
19.05	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
19.05	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
19.05	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
19.05	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
19.05	Single	8HNL	PS372424	8HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
19.05	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
19.05	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
19.05	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
19.05	Consensus	ccr2_off_allo	Other Ligand	5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
18.92	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
18.92	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
18.75	Single	3RFM	Caffeine	3RFM-A_2A-Caffeine
18.75	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
18.75	Single	6TQ9	SB-408124	6TQ9-OX₁-SB-408124
18.75	Consensus	hca2_on_allo	Orthosteric Ligand	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
18.52	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
18.52	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
18.52	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
18.52	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
18.52	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;2
18.52	Consensus	gi_formylpeptide	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
18.52	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
18.18	Single	4OO9	Mavoglurant	4OO9-mGlu₅-Mavoglurant
18.18	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
18.18	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
18.18	Single	7M8W	15r-Methyl-Prostaglandin D2	7M8W-DP₂-15r-Methyl-Prostaglandin D2-Na
18.18	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
18.18	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
18.18	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
18.18	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
18.18	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2
18.18	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2
18.18	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/&β;1/&γ;2
18.18	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
18.18	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
18.18	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
18.18	Consensus	cyslt1_off_ortoallo	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
18.18	Consensus	gi_muscarinic	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
18.18	Consensus	mglu2_on	Other Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
18.18	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
17.86	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
17.86	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
17.86	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
17.86	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
17.86	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
17.86	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
17.86	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.65	Single	3OE6	IT1t	3OE6-CXCR4-IT1t
17.65	Single	3OE8	IT1t	3OE8-CXCR4-IT1t
17.65	Single	5WKT	Octyl Beta-D-Glucopyranoside	5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
17.65	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
17.65	Single	7WC5	Psilocin	7WC5-5-HT_2A-Psilocin
17.65	Single	8EIT	Doconexent	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.39	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
17.39	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
17.39	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
17.39	Single	6IIU	Ramatroban	6IIU-TP-Ramatroban
17.39	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
17.39	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
17.39	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2
17.39	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
17.39	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/&β;1/&γ;2
17.39	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
17.39	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/&β;1/&γ;2
17.39	Single	8I9L	C3a anaphylatoxin	8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2
17.39	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2
17.39	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
17.39	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
17.39	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
17.24	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
17.24	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
17.24	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
17.24	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
17.24	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
17.24	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
17.24	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
17.24	Consensus	gs_melanocortin	Orthosteric Ligand	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2
17.14	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
17.14	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
17.14	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
17.14	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
17.14	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
17.14	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
16.67	Single	3OE9	IT1t	3OE9-CXCR4-IT1t
16.67	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
16.67	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
16.67	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.67	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
16.67	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2
16.67	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
16.67	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
16.67	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
16.67	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
16.67	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67	Single	7XP6	Strychnine	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
16.67	Single	7Y65	C5a peptide	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
16.67	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2
16.67	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
16.67	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2
16.67	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/&β;1/&γ;2
16.67	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/&β;1/&γ;2
16.67	Single	8K2X	CXCL10	8K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
16.67	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
16.67	Single	8XJO	U46619	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
16.67	Consensus	class-t_on	Orthosteric Ligand	taste2_on
16.67	Consensus	cyslt2_off	Orthosteric Ligand	6RZ6-CysLT₂-ONO-2570366 6RZ9-CysLT₂-ONO-2770372 6RZ8-CysLT₂-ONO-2080365
16.67	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off
16.67	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
16.67	Consensus	gs_class-t	Orthosteric Ligand	gs_taste
16.67	Consensus	gs_lipid	Orthosteric Ligand	gs_ffa gs_prostanoid
16.67	Consensus	gs_taste	Orthosteric Ligand	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
16.67	Consensus	mt1_on	Orthosteric Ligand	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
16.67	Consensus	mt2_on	Orthosteric Ligand	7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
16.67	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
16.67	Consensus	ot_on	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
16.67	Consensus	taste2_on	Orthosteric Ligand	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
16.22	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
16.13	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
16.13	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
16.00	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
16.00	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
16.00	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
16.00	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
16.00	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
16.00	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
16.00	Single	8INR	Alpha-MSH	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.00	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00	Single	8SAI	1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine	8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
16.00	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/&β;1/&γ;2
16.00	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2 8I95-C3a_B-EP54-Go/&β;1/&γ;2
16.00	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
16.00	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
16.00	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
16.00	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
16.00	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
16.00	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
15.79	Single	3ODU	IT1t	3ODU-CXCR4-IT1t
15.79	Single	3PWH	ZM241385	3PWH-A_2A-ZM241385
15.79	Single	3VG9	ZM241385	3VG9-A_2A-ZM241385-Antibody
15.79	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
15.79	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
15.79	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
15.79	Single	6RNK	NF-56-EJ40	6RNK-Succinate-NF-56-EJ40
15.79	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
15.79	Single	7F8Y	Devazepide	7F8Y-CCK_A-Devazepide
15.79	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
15.79	Single	7W0M	PubChem 122701908	7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
15.79	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
15.79	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2
15.79	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/&β;1/&γ;2
15.79	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
15.79	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
15.62	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
15.62	Single	7VGX	Neuropeptide Y	7VGX-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
15.62	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
15.62	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
15.62	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
15.62	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
15.62	Consensus	crf1_on	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
15.62	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
15.38	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
15.38	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
15.38	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
15.38	Consensus	fpr-alx_on	Orthosteric Ligand	fpr1-alx_on fpr2-alx_on
15.38	Consensus	nmur1_on	Orthosteric Ligand	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38	Consensus	sst2_on	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
15.38	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
15.00	Single	6ZA8	RTI-3a	6ZA8-NTS₁-RTI-3a
15.00	Single	7BB6	Acyclovir triphosphate	7BB6-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
15.00	Single	7F61	PF-03654746	7F61-H₃-PF-03654746-Cholesterol
15.00	Single	7VVO	PTH	7VVO-PTH1-PTH-Gs/&β;1/&γ;2
15.00	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
15.00	Single	8DWG	ML382	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00	Single	8GCM	L902688	8GCM-EP₄-L902688-Gi1/&β;1/&γ;2
15.00	Single	8HQN	9(S)-HODE	8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
15.00	Single	8JHN	MMF	8JHN-HCA₂-MMF-Go/&β;1/&γ;2
15.00	Single	8K2W	AMG487	8K2W-CXCR3-AMG487
15.00	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
15.00	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
15.00	Consensus	h3_on_allo	Orthosteric Ligand	7F61-H₃-PF-03654746-Cholesterol
14.81	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
14.81	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
14.81	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
14.81	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
14.81	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
14.81	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
14.81	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
14.71	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
14.71	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
14.63	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
14.63	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
14.29	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
14.29	Single	5NDD	AZ8838; Na	5NDD-PAR2-AZ8838; Na
14.29	Single	7F4D	Alpha-MSH	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
14.29	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
14.29	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
14.29	Single	8EJC	TAK-875	8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
14.29	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
14.29	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
14.29	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
14.29	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
14.29	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
14.29	Consensus	ffa1_on	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29	Consensus	gi_chemerin	Orthosteric Ligand	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
14.29	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
14.29	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.29	Consensus	prostanoid_off	Orthosteric Ligand	ep_off tp_off dp_off
13.89	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
13.89	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
13.79	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
13.79	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
13.79	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
13.79	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
13.79	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
13.79	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
13.79	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
13.79	Consensus	nmur2_on	Orthosteric Ligand	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79	Consensus	nmur_on	Orthosteric Ligand	nmur1_on nmur2_on
13.64	Single	4PHU	Fasiglifam	4PHU-FFA1 (GPR40)-Fasiglifam
13.64	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
13.64	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
13.64	Single	6D26	Fevipiprant	6D26-DP₂-Fevipiprant
13.64	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
13.64	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
13.64	Single	6Z4S	SR48692	6Z4S-NTS₁-SR48692
13.64	Single	7VFX	fMLF	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
13.64	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2
13.64	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
13.64	Consensus	ep3_on	Orthosteric Ligand	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
13.64	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
13.64	Consensus	ep_off	Orthosteric Ligand	ep4_off
13.51	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
13.33	Single	5MZP	Caffeine	5MZP-A_2A-Caffeine-Na
13.33	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
13.33	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
13.33	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
13.33	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
13.33	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
13.33	Single	8WCB	Cyclohexylammonium ion	8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.33	Single	8WCC	Cyclohexylammonium ion	8WCC-TA1-Cyclohexylammonium ion
13.33	Consensus	bk1_on	Orthosteric Ligand	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.33	Consensus	gs_bradykinin	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.33	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.33	Consensus	gs_neuromedin	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04	Single	5TZR	-	5TZR-FFA1 (GPR40)-MK8666
13.04	Single	5V56	TC114	5V56-SMO-TC114
13.04	Single	6Z4Q	SR142948A	6Z4Q-NTS₁-SR142948A
13.04	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
13.04	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04	Single	8GDB	PGE2	8GDB-EP₄-PGE2-Gs/&β;1/&γ;2
13.04	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
13.04	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
13.04	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/&β;1/&γ;2
13.04	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
13.04	Consensus	nts1_on_allo	Orthosteric Ligand	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.90	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
12.90	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/&β;1/&γ;2
12.90	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
12.90	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
12.90	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
12.90	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
12.90	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
12.90	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
12.50	Single	5MZJ	Theophylline	5MZJ-A_2A-Theophylline-Na
12.50	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
12.50	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
12.50	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
12.50	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
12.50	Single	7WC4	Serotonin	7WC4-5-HT_2A-Serotonin
12.50	Single	7XKE	Betahydroxyandrosterone	7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
12.50	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
12.50	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2
12.50	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2
12.50	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
12.50	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.50	Single	8PWN	Theophylline	8PWN-A_2A-Theophylline
12.50	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
12.50	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
12.50	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
12.50	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
12.50	Consensus	dp_off	Orthosteric Ligand	dp2_off
12.50	Consensus	gabab_off	Other Ligand	7C7S-GABA_B1, GABA_B2-CGP54626 7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid 6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
12.50	Consensus	gi_prostanoid	Orthosteric Ligand	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2 8GCM-EP₄-L902688-Gi1/&β;1/&γ;2
12.50	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.50	Consensus	nts1_off	Orthosteric Ligand	6Z4Q-NTS₁-SR142948A 6Z4S-NTS₁-SR48692
12.50	Consensus	nts_off	Orthosteric Ligand	nts1_off
12.50	Consensus	prostanoid_on	Orthosteric Ligand	ep_on fpa_on
12.50	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
12.12	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
12.12	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
12.12	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
12.12	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
12.00	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
12.00	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
12.00	Consensus	adgrg2_on	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
12.00	Consensus	cckb_on	Orthosteric Ligand	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
12.00	Consensus	ep4_on	Orthosteric Ligand	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2
12.00	Consensus	fpa_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
12.00	Consensus	gs_prostanoid	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
11.76	Single	8A2O	Theophylline	8A2O-A_2A-Theophylline-Na
11.54	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
11.54	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
11.54	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
11.54	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
11.54	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
11.54	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
11.54	Consensus	gs_bombesin	Orthosteric Ligand	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.43	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
11.43	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
11.11	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
11.11	Single	6ME5	Agomelatine	6ME5-MT₁-Agomelatine
11.11	Single	6ME9	Ramelteon	6ME9-MT₂-Ramelteon
11.11	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
11.11	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
11.11	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
11.11	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
11.11	Single	7S8O	(R)-Zinc-3573	7S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
11.11	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
11.11	Single	8F76	-	8F76-OR51E2-Gs/&β;1/&γ;2
11.11	Single	8JGB	Conorfamide-Tx2	8JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
11.11	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
11.11	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
11.11	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
11.11	Consensus	gip_on_allo	Other Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
11.11	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
11.11	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
11.11	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
10.71	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
10.71	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
10.71	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
10.53	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
10.53	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.53	Single	7S8N	(R)-Zinc-3573	7S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
10.53	Single	8H8J	Lodoxamide	8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
10.53	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/&β;1/&γ;2
10.53	Consensus	go_adhesion	Orthosteric Ligand	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.53	Consensus	go_class-b2	Orthosteric Ligand	go_adhesion
10.34	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
10.34	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
10.34	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
10.34	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
10.34	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
10.34	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
10.00	Single	4K5Y	CP-376395	4K5Y-CRF₁-CP-376395
10.00	Single	5U09	Taranabant	5U09-CB₁-Taranabant
10.00	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.00	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.00	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
10.00	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
10.00	Single	7W0O	Elabela	7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
10.00	Single	8HMP	PubChem 69921479	8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
10.00	Single	8HNN	SCH546738	8HNN-CXCR3-SCH546738
10.00	Single	8U4P	AMD3100	8U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
10.00	Single	8U8F	PML	8U8F-GPR3-PML-Gs/&β;1/&γ;2
10.00	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
9.76	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
9.76	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
9.68	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
9.68	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
9.68	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
9.68	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
9.68	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
9.52	Single	6FFI	MMPEP	6FFI-mGlu₅-MMPEP
9.52	Single	6ZIN	SR48692	6ZIN-NTS₁-SR48692
9.52	Single	7S8P	MS47134	7S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
9.52	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
9.52	Single	8HJ5	PubChem 139030531	8HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
9.52	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
9.52	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
9.52	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.38	Single	6FJ3	PTH	6FJ3-PTH1-PTH
9.38	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
9.38	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
9.38	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
9.38	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
9.38	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
9.38	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
9.38	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
9.38	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
9.09	Single	4Z9G	CP-376395	4Z9G-CRF₁-CP-376395
9.09	Single	6D27	CAY10471	6D27-DP₂-CAY10471
9.09	Single	6FFH	Fenobam	6FFH-mGlu₅-Fenobam
9.09	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
9.09	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
9.09	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
9.09	Single	8GTI	BMK-C205	8GTI-CRF₁-BMK-C205
9.09	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09	Single	8JGG	BAM8-22	8JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
9.09	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
9.09	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
9.09	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.82	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
8.82	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
8.70	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
8.70	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
8.70	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
8.70	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.70	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70	Single	7Y27	Somatostatin-14	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
8.70	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/&β;1/&γ;2
8.70	Single	8GTG	BMK-I152	8GTG-CRF₁-BMK-I152
8.70	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
8.70	Consensus	gs_sst	Orthosteric Ligand	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
8.33	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
8.33	Single	5V57	TC114	5V57-SMO-TC114
8.33	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
8.33	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
8.33	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
8.33	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
8.33	Single	7XOX	Cholecystokinin-8	7XOX-CCK_B-Cholecystokinin-8-Gq/&β;1/&γ;2
8.33	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2
8.33	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
8.33	Consensus	cml1_on	Orthosteric Ligand	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
8.33	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
8.11	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
8.00	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
8.00	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
8.00	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
8.00	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
8.00	Single	6C1R	PMX53	6C1R-C5a₁-PMX53-Avacopan; Na
8.00	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
8.00	Single	8GTM	BMK-C203	8GTM-CRF₁-BMK-C203
8.00	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00	Single	8HK2	C3a anaphylatoxin	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2
8.00	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/&β;1/&γ;2
8.00	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
8.00	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
8.00	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
8.00	Consensus	ep_on	Orthosteric Ligand	ep4_on ep2_on ep3_on
8.00	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
8.00	Consensus	nts_on	Orthosteric Ligand	nts1_on
7.89	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
7.69	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
7.69	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
7.69	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.69	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/&β;1/&γ;2
7.69	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2
7.69	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
7.69	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
7.69	Consensus	c5a1_off_ortoallo	Orthosteric Ligand	6C1Q-C5a₁-PMX53-NDT9513727 6C1R-C5a₁-PMX53-Avacopan; Na
7.69	Consensus	ep2_on	Orthosteric Ligand	7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2
7.69	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
7.41	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
7.14	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
7.14	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2
6.98	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
6.90	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
6.90	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
6.90	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
6.90	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
6.90	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.90	Consensus	sst_off	Orthosteric Ligand	sst2_off
6.67	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
6.67	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
6.45	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
6.45	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
6.45	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
6.45	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
6.25	Single	6W25	Ca	6W25-MC₄-SHU9119-Ca
6.25	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
6.25	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
6.25	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
6.06	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
6.06	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
6.06	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
6.06	Consensus	ghrh_on	Orthosteric Ligand	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
6.06	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
5.88	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
5.88	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
5.88	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
5.88	Single	7V68	PubChem 57664406	7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.88	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
5.88	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
5.71	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
5.71	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
5.71	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.71	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
5.71	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
5.56	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
5.56	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
5.56	Single	7VDM	Substance P	7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
5.56	Single	7XKD	Betahydroxyandrosterone	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.56	Single	7Y14	Beta-alanine	7Y14-MRGPRD-Beta-alanine
5.56	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
5.56	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.41	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
5.26	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
5.26	Single	6LI0	GTPL9804	6LI0-GPR52-GTPL9804
5.26	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
5.26	Single	7V6A	PubChem 9864275	7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
5.26	Single	7Y12	Beta-alanine	7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
5.26	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
5.13	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.13	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
5.13	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
5.13	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
5.00	Single	4MQT	LY2119620	4MQT-M₂-Iperoxo-LY2119620
5.00	Single	7TRP	LY2033298	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
5.00	Single	7UL2	SR48692	7UL2-NTS₁-SR48692-Na
5.00	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
5.00	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
5.00	Consensus	m4_on_allo	Other Ligand	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.00	Consensus	nts1_off_allo	Orthosteric Ligand	7UL2-NTS₁-SR48692-Na
5.00	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.76	Single	6KK1	PubChem 68178630	6KK1-GLP-1-PubChem 68178630
4.76	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
4.76	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
4.76	Single	7T94	PubChem 57664406	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
4.76	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
4.76	Single	8DWH	Compound-16	8DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
4.76	Consensus	class-f_off	Orthosteric Ligand	smo_off
4.76	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
4.76	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
4.76	Consensus	m2_on_allo	Other Ligand	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
4.76	Consensus	smo_on_allo	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.65	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
4.55	Single	6WJC	Muscarinic toxin 7	6WJC-M₁-Atropine-Muscarinic toxin 7
4.55	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
4.55	Single	7TRQ	VU0467154	7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
4.55	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
4.55	Single	7XJJ	Galanin	7XJJ-GAL₁-Galanin-Go/&β;1/&γ;2
4.55	Single	8IYX	YL-365	8IYX-GPR34-YL-365
4.55	Single	8JD6	N-(3-chlorophenyl)pyridine-2-carboxamide	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.55	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.55	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
4.55	Consensus	go_galanin	Orthosteric Ligand	7XJJ-GAL₁-Galanin-Go/&β;1/&γ;2
4.55	Consensus	m1_off_allo	Other Ligand	6WJC-M₁-Atropine-Muscarinic toxin 7
4.35	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
4.35	Single	6ORV	TT-OAD2	6ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
4.35	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
4.35	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
4.35	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
4.35	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
4.35	Single	7WQ3	Galanin	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
4.35	Single	8JR9	PCO371	8JR9-PTH1-PCO371-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
4.35	Consensus	gal1_on	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
4.35	Consensus	gi_galanin	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
4.17	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.17	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
4.17	Single	8GW8	KHF	8GW8-PTH1-KHF-Gs/&β;1/&γ;2
4.17	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.00	Single	6OS1	TRV026	6OS1-AT₁-TRV026
4.00	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
4.00	Single	7XBD	Galanin	7XBD-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
4.00	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.85	Single	6OS2	TRV026	6OS2-AT₁-TRV026
3.85	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
3.85	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1
3.85	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85	Consensus	galanin_on	Orthosteric Ligand	gal2_on gal1_on
3.70	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
3.70	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70	Consensus	gs_galanin	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.57	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
3.33	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
3.33	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
3.12	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
2.86	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
2.70	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
2.70	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.63	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.56	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.56	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.38	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.22	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.13	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB	8WPU
Class	C
SubFamily	Ion
Type	Calcium-sensing
SubType	CaS
Species	Homo sapiens
Ligand	-
Other Ligand(s)	Tryptophan; Cinacalcet; PO4; Ca
Protein Partners	chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2
PDB Resolution	3.1
Date	2023-11-22
D.O.I.	10.1038/s41422-023-00892-2

Net Summary
I_min	1.82
Number of Linked Nodes	2174
Number of Links	3153
Number of Hubs	677
Number of Links mediated by Hubs	2315
Number of Communities	55
Number of Nodes involved in Communities	996
Number of Links involved in Communities	1642

Path Summary
Number Of Nodes in MetaPath	1514
Number Of Links MetaPath	1513
Number of Shortest Paths	2042875781
Length Of Smallest Path	3
Average Path Length	128
Length of Longest Path	97
Minimum Path Strength	1.22
Average Path Strength	8.07847
Maximum Path Strength	33.545
Minimum Path Correlation	0.72
Average Path Correlation	1
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	1.81818
Average % Of Corr. Nodes	128
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	128
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NAG
PDB Residues	H:H:?1 H:H:?2 H:H:?3 H:H:?4 H:H:?5 H:H:?6 H:H:?7 H:H:?8 H:H:?9 H:H:?10 H:H:?11 H:H:?12 H:H:?13
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetyl-D-glucosamine
Identifier	N-[(2R,3R,4R,5S,6R)-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl]ethanamide
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES	CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


Code	YP4
PDB Residues	X:X:?4 W:W:?4
Environment Details	Open EMBL-EBI Page
Code	YP4
Name	Cinacalcet
Synonyms	Cinacalcet (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethane amine N-((1R)-1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine CNC Cinacalcet hydrochloride
Identifier	~{N}-[(1~{R})-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine
Formula	C22 H22 F3 N
Molecular Weight	357.412
SMILES	C[C@H](c1cccc2c1cccc2)NCCCc3cccc(c3)C(F)(F)F
PubChem	156419
Formal Charge	0
Total Atoms	48
Total Chiral Atoms	1
Total Bonds	50
Total Aromatic Bonds	17


Code	CA
PDB Residues	X:X:?3 I:I:?2 I:I:?1 W:W:?3
Environment Details	Open EMBL-EBI Page
Code	CA
Name	CALCIUM ION
Synonyms
Identifier	calcium(+2) cation
Formula	Ca
Molecular Weight	40.078
SMILES	[Ca+2]
PubChem
Formal Charge	2
Total Atoms	1
Total Chiral Atoms	0
Total Bonds	0
Total Aromatic Bonds	0


Code	PO4
PDB Residues	X:X:?2 W:W:?2
Environment Details	Open EMBL-EBI Page
Code	PO4
Name	Phosphate ion
Synonyms	Phosphate Phosphate ion Orthophosphate
Identifier	phosphate
Formula	O4 P
Molecular Weight	94.971
SMILES	[O-]P(=O)([O-])[O-]
PubChem	1061
Formal Charge	-3
Total Atoms	5
Total Chiral Atoms	0
Total Bonds	4
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	S
Protein	Receptor
UniProt	P41180
Sequence	>8WPU_Chain_S Y G P D Q R A Q K K G D I I L G G L F P I H F G V A A K D Q D L K S R P E S V E C I R Y N F R G F R W L Q A M I F A I E E I N S S P A L L P N L T L G Y R I F D T C N T V S K A L E A T L S F V A Q N K I D S L N L C S E H I P S T I A V V G A T G S G V S T A V A N L L G L F Y I P Q V S Y A S S S R L L S N K N Q F K S F L R T I P N D E H Q A T A M A D I I E Y F R W N W V G T I A A D D D Y G R P G I E K F R E E A E E R D I C I D F S E L I S Q Y S D E E E I Q H V V E V I Q N S T A K V I V V F S S G P D L E P L I K E I V R R N I T G K I W L A S E A W A S S S L I A M P Q Y F H V V G G T I G F A L K A G Q I P G F R E F L K K V H P R K S V H N G F A K E F W E E T F N C H L Q F R P L C T G D E N I S S V E T P Y I D Y T H L R I S Y N V Y L A V Y S I A H A L Q D I Y T C L P G R G L F T N G S C A D I K K V E A W Q V L K H L R H L N F T N N M G E Q V T F D E C G D L V G N Y S I I N W H L S P E D G S I V F K E V G Y Y N V Y A K K G E R L F I N E E K I L W S G F S R E V P F S N C S R D C L A G T R K G I I E G E P T C C F E C V E C P D G E Y S D E T D A S A C N K C P D D F W S N E N H T S C I A K E I E F L S W T E P F G I A L T L F A V L G I F L T A F V L G V F I K F R N T P I V K A T N R E L S Y L L L F S L L C C F S S S L F F I G E P Q D W T C R L R Q P A F G I S F V L C I S C I L V K T N R V L L V K W W G L N L Q F L L V F L C T F M Q I V I C V I W L Y T A P P S S Y R N Q E L E D E I I F I T C H E G S L M A L G F L I G Y T C L L A A I C F F F A F K S R K L P E N F N E A K F I T F S M L I F F I V W I S F I P A Y A S T Y G K F V S A V E V I A I L A A S F G L L A C I F F N K I Y I I L F K P S R N T I E E V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P41180
Sequence	>8WPU_Chain_R Y G P D Q R A Q K K G D I I L G G L F P I H F G V A A K D Q D L K S R P E S V E C I R Y N F R G F R W L Q A M I F A I E E I N S S P A L L P N L T L G Y R I F D T C N T V S K A L E A T L S F V A Q N K I D S L N L D C S E H I P S T I A V V G A T G S G V S T A V A N L L G L F Y I P Q V S Y A S S S R L L S N K N Q F K S F L R T I P N D E H Q A T A M A D I I E Y F R W N W V G T I A A D D D Y G R P G I E K F R E E A E E R D I C I D F S E L I S Q Y S D E E E I Q H V V E V I Q N S T A K V I V V F S S G P D L E P L I K E I V R R N I T G K I W L A S E A W A S S S L I A M P Q Y F H V V G G T I G F A L K A G Q I P G F R E F L K K V H P R K S V H N G F A K E F W E E T F N C H L Q R P L C T G D E N I S S V E T P Y I D Y T H L R I S Y N V Y L A V Y S I A H A L Q D I Y T C L P G R G L F T N G S C A D I K K V E A W Q V L K H L R H L N F T N N M G E Q V T F D E C G D L V G N Y S I I N W H L S P E D G S I V F K E V G Y Y N V Y A K K G E R L F I N E E K I L W S G F S R E V P F S N C S R D C L A G T R K G I I E G E P T C C F E C V E C P D G E Y S D E T D A S A C N K C P D D F W S N E N H T S C I A K E I E F L S W T E P F G I A L T L F A V L G I F L T A F V L G V F I K F R N T P I V K A T N R E L S Y L L L F S L L C C F S S S L F F I G E P Q D W T C R L R Q P A F G I S F V L C I S C I L V K T N R V L L V F E A K W G L N L Q F L L V F L C T F M Q I V I C V I W L Y T A P P S S Y R N Q E L E D E I I F I T C H E G S L M A L G F L I G Y T C L L A A I C F F F A F K S R K L P E N F N E A K F I T F S M L I F F I V W I S F I P A Y A S T Y G K F V S A V E V I A I L A A S F G L L A C I F F N K I Y I I L F K P S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	A
Protein	G Protein α Sub unit
UniProt	P63092
Sequence	>8WPU_Chain_A V S A E D K A A A E R S K M I D K N L R E D G E K A R R T L R L L L L G A D N S G K S T I V K Q M R I F E T K F Q V D K V N F H M F D V G G Q R D E R R K W I Q C F N D V T A I I F V V D S S D Y N R L Q E A L N D F K S I W N N R W L R T I S V I L F L N K Q D L L A E K V L A G K S K I E D Y F P E F A R Y T D P R V T R A K Y F I R K E F V D I S T A S G D G R H I C Y P H F T C A V D T E N A R R I F N D C K D I I L Q M N L R E Y N L V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	B
Protein	G Protein β Sub unit
UniProt	P62873
Sequence	>8WPU_Chain_B S E L D Q L R Q E A E Q L K N Q I R D A R K A C A D A T L S Q I T N N I D P V G R I Q M R T R R T L R G H L A K I Y A M H W G T D S R L L V S A S Q D G K L I I W D S Y T T N K V H A I P L R S S W V M T C A Y A P S G N Y V A C G G L D N I C S I Y N L K T R E G N V R V S R E L A G H T G Y L S C C R F L D D N Q I V T S S G D T T C A L W D I E T G Q Q T T T F T G H T G D V M S L S L A P D T R L F V S G A C D A S A K L W D V R E G M C R Q T F T G H E S D I N A I C F F P N G N A F A T G S D D A T C R L F D L R A D Q E L M T Y S H D N I I C G I T S V S F S K S G R L L L A G Y D D F N C N V W D A L K A D R A G V L A G H D N R V S C L G V T D D G M A V A T G S W D S F L K I W N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	G
Protein	G Protein γ Sub unit
UniProt	P59768
Sequence	>8WPU_Chain_G A S I A Q A R K L V E Q L K M E A N I D R I K V S K A A A D L M A Y C E A H A K E D P L L T P V P A S E N P F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7DD5	C	Ion	Calcium-sensing	CaS	Gallus gallus	Ca	Ca; Ca; Tryptophan; NPS-2143	-	3.2	2021-06-16	10.1126/sciadv.abg1483
	7DD6	C	Ion	Calcium-sensing	CaS	Gallus gallus	Ca	Ca; Ca; Tryptophan	-	3.2	2021-06-16	10.1126/sciadv.abg1483
	7DD7	C	Ion	Calcium-sensing	CaS	Gallus gallus	Ca	Ca; Ca; Tryptophan; Evocalcet	-	3.2	2021-06-16	10.1126/sciadv.abg1483
	7DTT	C	Ion	Calcium-sensing	CaS	Homo sapiens	Ca	Ca	-	3.8	2021-03-10	10.1038/s41422-021-00474-0
	7DTU	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Tryptophan	-	4.4	2021-03-10	10.1038/s41422-021-00474-0
	7DTV	C	Ion	Calcium-sensing	CaS	Homo sapiens	Ca	Ca; Tryptophan	-	3.5	2021-03-10	10.1038/s41422-021-00474-0
	7DTW	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	-	-	4.5	2021-03-10	10.1038/s41422-021-00474-0
	7E6T	C	Ion	Calcium-sensing	CaS	Homo sapiens	Ca	Ca; Ca; Cyclomethyltryptophan; PO4	-	3	2021-09-22	10.7554/eLife.68578
	7E6U	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	-	-	6	2021-09-22	10.7554/eLife.68578
	7M3E	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; NPS-2143; PO4	-	3.2	2021-06-30	10.1038/s41586-021-03691-0
	7M3F	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4	-	2.8	2021-06-30	10.1038/s41586-021-03691-0
	7M3G	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	-	2.5	2021-06-30	10.1038/s41586-021-03691-0
	7M3J	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	NPS-2143; PO4	-	4.1	2021-06-30	10.1038/s41586-021-03691-0
	7SIL	C	Ion	Calcium-sensing	CaS	Homo sapiens	Ca	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	-	2.7	2022-01-19	10.1073/pnas.2115849118
	7SIM	C	Ion	Calcium-sensing	CaS	Homo sapiens	Ca	Ca; Ca; Cyclomethyltryptophan; PO4	-	2.7	2022-01-19	10.1073/pnas.2115849118
	7SIN	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	NPS-2143	-	5.9	2022-01-19	10.1073/pnas.2115849118
	8SZF	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	-	2.8	2024-02-07	10.1038/s41586-024-07055-2
	8SZG	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	chim(NtGi1-Gq)/&β;1/&γ;2	3.6	2024-02-07	10.1038/s41586-024-07055-2
	8SZH	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	Gi1/&β;1/&γ;2	3.1	2024-02-07	10.1038/s41586-024-07055-2
	8SZI	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	Gi3/&β;1/&γ;2	3.5	2024-02-07	10.1038/s41586-024-07055-2
	8WPG	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Tryptophan; Cinacalcet; PO4; Ca	-	2.7	2023-11-22	10.1038/s41422-023-00892-2
	8WPU	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Tryptophan; Cinacalcet; PO4; Ca	chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2	3.1	2023-11-22	10.1038/s41422-023-00892-2
	9AXF	C	Ion	Calcium-sensing	CaS	Homo sapiens	Ca	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	chim(NtGi1-Gs-CtGq)/&β;1/&γ;2	3.5	2024-04-17	10.1038/s41586-024-07331-1
	9AYF	C	Ion	Calcium-sensing	CaS	Homo sapiens	Ca	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	Gi1/&β;1/&γ;2	3.6	2024-04-17	10.1038/s41586-024-07331-1

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