Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1S:S:I32 4.066506
2S:S:L37 3.855406
3S:S:F38 8.0275427
4S:S:P39 6.37167626
5S:S:I40 6.6075425
6S:S:H41 7.07167627
7S:S:F42 10.5254263
8S:S:P55 8.4425466
9S:S:R62 6.61754264
10S:S:Y63 6.19857725
11S:S:F65 7.21422
12S:S:R66 11.73425
13S:S:F68 8.746527
14S:S:R69 6.09833628
15S:S:W70 7.5971025
16S:S:L71 4.9975424
17S:S:Q72 5.528527
18S:S:M74 4.825628
19S:S:I75 5.52424
20S:S:F76 6.6625407
21S:S:I81 6.0775499
22S:S:L87 5.4475496
23S:S:Y95 6.85628
24S:S:R96 3.8645254
25S:S:I97 6.032528
26S:S:F98 7.056676254
27S:S:T100 4.8525427
28S:S:K106 2.924304
29S:S:F114 5.215405
30S:S:T145 6.41667625
31S:S:V153 5.2275476
32S:S:L157 4.584577
33S:S:F160 8.135407
34S:S:P163 4.19254138
35S:S:Q164 6.8375478
36S:S:Y167 7.91528
37S:S:R172 6.84404
38S:S:L173 5.128505
39S:S:L174 8.0425477
40S:S:F180 8.2325475
41S:S:F183 8.302578
42S:S:L184 4.1475406
43S:S:R185 6.73333679
44S:S:I187 4.088576
45S:S:Q193 5.24629
46S:S:I201 3.8325486
47S:S:F204 8.785487
48S:S:W206 7.68833689
49S:S:W208 8.995649
50S:S:T211 4.8875405
51S:S:I212 3.2875426
52S:S:Y218 7.84333627
53S:S:K225 6.6425273
54S:S:R227 10.1975404
55S:S:E229 5.1285275
56S:S:R233 6.334504
57S:S:F239 5.83406
58S:S:V266 7.388587
59S:S:I267 5.7025427
60S:S:F270 5.334527
61S:S:S271 3.5424
62S:S:P274 3.515403
63S:S:D275 4.534525
64S:S:L276 5.472525
65S:S:E277 6.46754262
66S:S:L279 3.255425
67S:S:I280 4.2175425
68S:S:K291 3.415426
69S:S:L294 3.63407
70S:S:W299 7.746527
71S:S:S302 4.2075405
72S:S:L304 5.2725262
73S:S:I305 4.584524
74S:S:Y310 6.53523
75S:S:F311 6.3875403
76S:S:V313 3.2925403
77S:S:F320 5.9525426
78S:S:I327 5.4025406
79S:S:F330 6.164508
80S:S:V337 4.364525
81S:S:N345 3.94833628
82S:S:E350 7.26425
83S:S:F351 9.79167626
84S:S:W352 11.6745218
85S:S:L360 4.955214
86S:S:E399 9.00254218
87S:S:I401 3.4025407
88S:S:Y408 8.51833623
89S:S:Y411 9.84405
90S:S:L414 4.188526
91S:S:S417 4.7426
92S:S:Y418 8.844597
93S:S:Y421 10.6375498
94S:S:Y425 9.97498
95S:S:Q432 6.5075497
96S:S:Y435 5.9925493
97S:S:F444 4.5045143
98S:S:W458 10.165144
99S:S:Q459 7.8545147
100S:S:L461 5.32254137
101S:S:K462 6.78754134
102S:S:H463 5.38405
103S:S:L464 3.73754137
104S:S:F469 9.826598
105S:S:N471 5.452596
106S:S:M473 5.05494
107S:S:D484 8.015478
108S:S:N493 6.05489
109S:S:W494 7.69143727
110S:S:V508 3.4125487
111S:S:Y511 7.464505
112S:S:N512 9.02754204
113S:S:V513 4.63403
114S:S:Y514 5.52754204
115S:S:I523 5.0275486
116S:S:W530 8.56167688
117S:S:T550 2.9354366
118S:S:R551 9.8125407
119S:S:E558 3.744545
120S:S:P559 4.6225446
121S:S:C562 6.095449
122S:S:Y573 2.8225406
123S:S:C582 4.485409
124S:S:W590 4.98506
125S:S:T596 2.776505
126S:S:W608 7.47754405
127S:S:E610 4.9925397
128S:S:T627 3.5975407
129S:S:T640 5.11754429
130S:S:P641 5.04754428
131S:S:R648 5.24508
132S:S:L650 64288
133S:S:L655 5.75754159
134S:S:F662 6.2065418
135S:S:P672 4.864169
136S:S:R680 7.924168
137S:S:Q681 6.99559
138S:S:F684 9.066558
139S:S:F688 5.69608
140S:S:I695 4.475407
141S:S:F706 7.654449
142S:S:Q724 7.2345288
143S:S:Q735 6.874559
144S:S:W742 5.74459
145S:S:I760 4.7885235
146S:S:I761 5.1754387
147S:S:F762 5.748336237
148S:S:E767 4.7875457
149S:S:I777 4.2125458
150S:S:Y779 9.1325459
151S:S:F809 6.31754459
152S:S:F814 8.8525409
153S:S:W818 9.18559
154S:S:F821 7.016559
155S:S:T828 3.6575458
156S:S:F853 7.0125159
157S:S:R866 10.85254436
158R:R:L37 4.2275406
159R:R:F38 7.415417
160R:R:P39 5.6425416
161R:R:I40 8.49405
162R:R:H41 7.176517
163R:R:F42 9.8625433
164R:R:V44 4.524512
165R:R:Y63 6.20429715
166R:R:F65 6.918512
167R:R:R66 10.134515
168R:R:F68 7.455617
169R:R:R69 6.498518
170R:R:W70 7.38889915
171R:R:L71 3.8825414
172R:R:Q72 5.978517
173R:R:M74 4.84167618
174R:R:I75 5.8525414
175R:R:F76 6.9025407
176R:R:I81 7.04419
177R:R:L87 4.678516
178R:R:Y95 8.836518
179R:R:R96 5.96167614
180R:R:I97 5.41518
181R:R:F98 6.595614
182R:R:C101 5.705418
183R:R:T111 5.1675417
184R:R:F114 4.91571715
185R:R:K119 7.0625313
186R:R:T145 5.46833615
187R:R:T151 3.4625405
188R:R:V153 5.2775416
189R:R:L157 4.298517
190R:R:F160 6.2665317
191R:R:I162 3.688506
192R:R:P163 3.7825468
193R:R:Q164 5.268518
194R:R:Y167 7.296518
195R:R:R172 5.85514
196R:R:L173 4.556515
197R:R:L174 8.0425417
198R:R:S175 4.065418
199R:R:F183 8.098518
200R:R:L184 4.825406
201R:R:R185 6.54667619
202R:R:I187 3.778516
203R:R:N189 5.43418
204R:R:Q193 5.55167619
205R:R:I201 4.12754106
206R:R:F204 9.88254107
207R:R:W206 7.1345109
208R:R:W208 9.538539
209R:R:V209 3.65754108
210R:R:T211 4.8675405
211R:R:I212 3.552536
212R:R:Y218 7.47833617
213R:R:K225 7.5525413
214R:R:R227 8.1625404
215R:R:E229 7.0925415
216R:R:R233 9.295404
217R:R:F239 5.38536
218R:R:I243 3.258535
219R:R:Q253 5.70254243
220R:R:V255 4.435435
221R:R:V258 5.535434
222R:R:V266 5.9025107
223R:R:I267 5.1175437
224R:R:P274 3.86433
225R:R:L276 5.08333635
226R:R:L279 4.3275435
227R:R:E282 7.56754246
228R:R:R286 6.58254244
229R:R:I292 3.26754107
230R:R:W293 5.655438
231R:R:L294 3.645407
232R:R:E297 7.3975418
233R:R:W299 9.4437
234R:R:S302 3.8325435
235R:R:L304 6.234532
236R:R:I305 3.944534
237R:R:F311 8.8125403
238R:R:V313 3.235433
239R:R:I327 6.22416
240R:R:F330 6.825618
241R:R:L334 7.124516
242R:R:V337 4.1075415
243R:R:N345 4.56833618
244R:R:F347 7.84415
245R:R:F351 8.17714716
246R:R:W352 12.9725418
247R:R:T355 6.0525414
248R:R:L360 7.28254474
249R:R:R392 2.202501
250R:R:Y408 8.335613
251R:R:I409 5.12415
252R:R:Y411 8.0775405
253R:R:L414 6.1475416
254R:R:I416 7.814514
255R:R:S417 5.35416
256R:R:Y418 8.06167617
257R:R:Y421 9.9518
258R:R:Y425 11.6418
259R:R:Q432 5.0425407
260R:R:F444 5.864563
261R:R:I452 2.7175403
262R:R:W458 9.996564
263R:R:Q459 8.382567
264R:R:L461 4.9125467
265R:R:K462 5.598564
266R:R:L464 3.59567
267R:R:F469 12.605418
268R:R:N471 6.286516
269R:R:M473 5.73414
270R:R:D484 8.485418
271R:R:I491 3.3275408
272R:R:N493 6.624109
273R:R:W494 9.275467
274R:R:S497 3.296503
275R:R:Y511 6.702505
276R:R:Y514 7.81254174
277R:R:L521 5.6854105
278R:R:I528 7.064107
279R:R:W530 9.0956108
280R:R:C546 4.524229
281R:R:R551 10.14407
282R:R:C582 5.32754379
283R:R:F589 3.4075405
284R:R:W590 8.345486
285R:R:T596 2.6475405
286R:R:F605 4.3875407
287R:R:L606 4.1565119
288R:R:W608 6.6375405
289R:R:E610 6.6454117
290R:R:F612 4.644118
291R:R:T640 4.9945539
292R:R:L655 5.37254529
293R:R:F662 8.06754518
294R:R:F668 8.8409
295R:R:I669 6.7254118
296R:R:P672 2.9865189
297R:R:R680 7.96754188
298R:R:Q681 6.024129
299R:R:F684 7.993336128
300R:R:F688 6.235408
301R:R:C691 2.83254548
302R:R:I692 4.574557
303R:R:L696 4.89254558
304R:R:W719 4.5725406
305R:R:Q724 4.44508
306R:R:W742 4.123336129
307R:R:A746 1.8025406
308R:R:I760 6.984115
309R:R:I761 6.2354507
310R:R:F762 5.9256117
311R:R:I763 3.8175407
312R:R:F788 4.50754568
313R:R:F790 4.81407
314R:R:L797 3.834198
315R:R:P798 6.63754199
316R:R:F801 4.285409
317R:R:M811 4.415409
318R:R:F814 6.9665129
319R:R:W818 12.5754129
320R:R:F821 4.45833609
321R:R:P823 3.51559
322R:R:V838 5.10254117
323R:R:F853 7.0125529
324R:R:N867 5.384539
325H:H:?1 17.76336200
326H:H:?3 17.07640
327H:H:?5 16.4756170
328H:H:?7 17.9867640
329X:X:?1 7.41625820
330X:X:?2 9.57429720
331I:I:?1 6.3775420
332X:X:?3 10.861050
333W:W:?1 7.7910
334W:W:?2 9.87167610
335I:I:?3 5.025600
336W:W:?3 11.76449120
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1S:S:L334 S:S:Y408 22.778611.72NoYes063
2S:S:F330 S:S:L334 11.561114.61YesNo086
3S:S:F330 S:S:R69 19.43153.21YesYes088
4S:S:R69 S:S:W70 16.4453YesYes285
5S:S:L334 S:S:Y411 11.54443.52NoYes065
6S:S:R69 S:S:Y411 12.328311.32YesYes085
7S:S:W70 X:X:?1 33.95633.28YesYes250
8S:S:S147 X:X:?1 33.58516.48NoYes080
9S:S:S147 S:S:S171 33.5513.26NoNo087
10S:S:L173 S:S:S171 33.52394.5YesNo057
11S:S:D217 S:S:L173 40.2924.07NoYes065
12S:S:D217 S:S:R220 40.26513.57NoNo066
13R:R:F183 R:R:Q164 12.47189.37YesYes188
14R:R:L157 R:R:Q164 14.09085.32YesYes178
15R:R:I162 R:R:L157 10.40944.28YesYes067
16S:S:T145 X:X:?1 15.60773.18YesYes250
17R:R:L173 S:S:R220 34.39996.07YesNo056
18R:R:L173 R:R:S171 24.1884.5YesNo057
19R:R:S147 R:R:S171 24.20413.26NoNo087
20S:S:I327 S:S:L414 11.62032.85YesYes066
21S:S:I327 S:S:Y421 11.152113.3YesYes068
22S:S:Y421 S:S:Y425 10.33617.87YesYes988
23R:R:S147 W:W:?1 22.31666.48NoYes080
24S:S:Y218 X:X:?1 55.924121.07YesYes270
25R:R:R66 W:W:?1 12.4675.24YesYes150
26L:L:?1 R:R:R66 31.48168.93NoYes005
27L:L:?1 R:R:S302 31.50435.52NoYes005
28S:S:D238 S:S:W208 61.166318.98NoYes089
29S:S:D238 S:S:S262 61.19968.83NoNo087
30S:S:F239 S:S:S262 61.28445.28YesNo067
31S:S:F239 S:S:I267 61.47743.77YesYes067
32S:S:I212 S:S:I267 60.11062.94YesYes267
33S:S:I212 S:S:I243 60.38084.42YesNo265
34S:S:I243 S:S:S271 62.12134.64NoYes254
35S:S:A214 S:S:S271 33.26193.42NoYes254
36S:S:A214 S:S:D216 33.30063.09NoNo256
37S:S:D216 S:S:Y218 67.36323.45NoYes267
38S:S:D275 S:S:S271 33.6672.94YesYes254
39S:S:D216 S:S:D275 34.04613.99NoYes265
40S:S:C542 S:S:W208 58.603315.67NoYes499
41S:S:I401 S:S:W352 10.45194.7YesYes078
42S:S:C542 S:S:S543 59.31623.44NoNo098
43S:S:F563 S:S:S543 59.31493.96NoNo078
44S:S:C546 S:S:F563 1002.79NoNo097
45S:S:C546 S:S:T550 99.7085.07NoYes3696
46S:S:G549 S:S:T550 99.57511.82NoYes096
47S:S:C568 S:S:G549 98.97871.96NoNo099
48S:S:C568 S:S:C582 42.33477.28NoYes099
49S:S:C582 S:S:R551 41.81854.18YesYes097
50R:R:R551 S:S:R551 41.407319.19YesYes077
51S:S:F563 S:S:K552 42.522316.13NoNo078
52R:R:I554 S:S:K552 42.38512.91NoNo038
53R:R:K552 S:S:I554 42.25372.91NoNo083
54R:R:I554 S:S:I554 42.3524.42NoNo033
55S:S:C568 S:S:H595 56.96664.42NoNo095
56R:R:C582 R:R:R551 41.10214.18YesYes097
57S:S:H595 S:S:S591 56.78352.79NoNo058
58S:S:S591 S:S:W590 55.87393.71NoYes086
59S:S:I761 S:S:K601 54.24135.82YesNo078
60S:S:K601 S:S:W590 54.42292.32NoYes086
61S:S:I603 S:S:I761 53.96964.42NoYes047
62S:S:F605 S:S:I603 53.87922.51NoNo074
63S:S:E671 S:S:F605 53.608913.99NoNo047
64S:S:L842 S:S:S665 10.28373NoNo098
65S:S:I841 S:S:S665 10.40423.1NoNo098
66S:S:F668 S:S:I841 29.24673.77NoNo099
67S:S:F668 S:S:R680 52.526714.97NoYes098
68S:S:P672 S:S:R680 52.81285.76YesYes1698
69S:S:E671 S:S:P672 53.51883.14NoYes049
70R:R:P823 S:S:V836 16.21433.53YesNo598
71S:S:F821 S:S:V836 18.09523.93YesNo598
72S:S:E837 S:S:F821 16.60858.16NoYes599
73S:S:E837 S:S:F668 23.220313.99NoNo099
74S:S:M811 S:S:S810 17.75934.6NoNo099
75S:S:L848 S:S:S810 18.24863NoNo079
76S:S:F688 S:S:L848 18.61676.09YesNo087
77S:S:F684 S:S:F688 19.26157.5YesYes088
78S:S:F684 S:S:I841 18.914113.82YesNo089
79R:R:F684 R:R:I841 19.226615.07YesNo1289
80R:R:F668 R:R:I841 19.52983.77YesNo099
81R:R:F668 R:R:R680 36.152118.17YesYes098
82R:R:P672 R:R:R680 36.37962.88YesYes1898
83R:R:I763 R:R:P672 36.95813.39YesYes079
84R:R:I763 R:R:R752 37.76375.01YesNo073
85R:R:I761 R:R:R752 37.67173.76YesNo5073
86R:R:I761 R:R:K601 38.89738.72YesNo078
87R:R:K601 R:R:W590 38.98442.32NoYes086
88R:R:S591 R:R:W590 39.22744.94NoYes4886
89R:R:H595 R:R:S591 39.419912.55NoNo058
90R:R:C568 R:R:H595 39.59454.42NoNo095
91R:R:C568 R:R:C582 40.59447.28NoYes099
92R:R:E837 W:W:?3 12.963312.32NoYes1290
93R:R:E837 R:R:F668 13.36999.33NoYes099
94R:R:I822 W:W:?3 15.07463.32NoYes070
95R:R:I822 R:R:P823 15.18083.39NoYes079
96R:R:F330 R:R:L334 13.26417.05YesYes186
97R:R:F330 R:R:R69 24.6453.21YesYes188
98R:R:R66 R:R:R69 37.06925.33YesYes158
99R:R:L334 R:R:Y408 18.7848.21YesYes163
100R:R:L334 R:R:Y411 13.0123.52YesYes065
101R:R:R69 R:R:Y411 13.487310.29YesYes085
102R:R:D238 R:R:F239 44.43483.58NoYes386
103R:R:F239 R:R:I267 38.67663.77YesYes367
104R:R:I212 R:R:I267 38.11222.94YesYes367
105R:R:I212 R:R:I243 16.93994.42YesYes365
106R:R:D238 R:R:W208 44.414716.75NoYes389
107R:R:L276 R:R:V269 10.61462.98YesNo355
108R:R:I305 R:R:L276 21.29374.28YesYes345
109R:R:I305 R:R:S302 30.55033.1YesYes345
110R:R:V269 R:R:W299 10.63869.81NoYes357
111R:R:I305 R:R:W299 10.69595.87YesYes347
112R:R:C542 R:R:S543 42.13393.44NoNo098
113R:R:F563 R:R:S543 42.10195.28NoNo078
114R:R:F563 R:R:K552 41.935218.61NoNo2278
115R:R:F853 R:R:I852 19.960211.3YesNo099
116R:R:I695 R:R:I852 20.39052.94NoNo079
117R:R:I695 R:R:L654 15.66512.85NoNo078
118R:R:C691 R:R:L654 17.55533.17YesNo088
119R:R:C691 R:R:L848 19.13083.17YesNo5487
120R:R:L848 R:R:S810 19.76953NoNo079
121R:R:M811 R:R:S810 20.40414.6YesNo099
122R:R:F688 R:R:I692 18.2315.02YesYes087
123R:R:F684 R:R:F688 17.58096.43YesYes088
124R:R:F788 R:R:M811 14.00034.98YesYes089
125R:R:F788 R:R:F815 14.6514.29YesNo087
126R:R:F814 R:R:F815 15.09035.36YesNo097
127R:R:F814 W:W:?3 16.11082.83YesYes1290
128S:S:I81 S:S:Y425 12.695310.88YesYes998
129S:S:R66 S:S:R69 15.4375.33YesYes258
130S:S:R66 X:X:?1 19.88165.24YesYes250
131R:R:C542 R:R:W208 41.970116.98NoYes399
132R:R:I243 R:R:L276 10.75542.85YesYes355
133R:R:I212 R:R:V269 21.18274.61YesNo365
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:F42 S:S:R62 8.55 26 Yes Yes 3 4 1 2
S:S:F42 S:S:N64 19.33 26 Yes No 3 4 1 2
S:S:F42 S:S:L304 9.74 26 Yes Yes 3 2 1 2
M:M:?1 S:S:F42 4.48 0 No Yes 0 3 0 1
S:S:L304 S:S:R62 4.86 26 Yes Yes 2 4 2 2
S:S:G273 S:S:S302 3.71 0 No Yes 4 5 2 1
S:S:L304 S:S:S302 4.5 26 Yes Yes 2 5 2 1
S:S:I305 S:S:S302 3.1 2 Yes Yes 4 5 2 1
M:M:?1 S:S:S302 5.52 0 No Yes 0 5 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:P39 S:S:W70 5.4 2 Yes Yes 6 5 2 1
S:S:P39 S:S:T145 10.49 2 Yes Yes 6 5 2 1
I:I:?1 S:S:P39 9.06 2 Yes Yes 0 6 2 2
S:S:R66 S:S:R69 5.33 2 Yes Yes 5 8 1 2
S:S:R66 S:S:W70 13.99 2 Yes Yes 5 5 1 1
S:S:R66 X:X:?1 5.24 2 Yes Yes 5 0 1 0
S:S:R66 X:X:?2 22.36 2 Yes Yes 5 0 1 2
S:S:G67 S:S:W70 5.63 0 No Yes 4 5 2 1
S:S:R69 S:S:W70 3 2 Yes Yes 8 5 2 1
S:S:R69 S:S:S417 3.95 2 Yes Yes 8 6 2 2
S:S:R69 X:X:?2 9.78 2 Yes Yes 8 0 2 2
S:S:T145 S:S:W70 6.06 2 Yes Yes 5 5 1 1
S:S:W70 S:S:Y167 6.75 2 Yes Yes 5 8 1 2
S:S:I416 S:S:W70 16.44 2 No Yes 4 5 2 1
S:S:S417 S:S:W70 4.94 2 Yes Yes 6 5 2 1
S:S:W70 X:X:?1 3.28 2 Yes Yes 5 0 1 0
S:S:W70 X:X:?2 10.48 2 Yes Yes 5 0 1 2
S:S:T145 S:S:Y167 9.99 2 Yes Yes 5 8 1 2
S:S:A168 S:S:T145 3.36 0 No Yes 5 5 2 1
S:S:T145 X:X:?1 3.18 2 Yes Yes 5 0 1 0
I:I:?1 S:S:T145 5.42 2 Yes Yes 0 5 2 1
S:S:S147 S:S:S171 3.26 0 No No 8 7 1 2
S:S:S147 X:X:?1 6.48 0 No Yes 8 0 1 0
S:S:A168 S:S:I416 3.25 0 No No 5 4 2 2
S:S:I187 S:S:S170 6.19 7 Yes No 6 7 2 1
S:S:D190 S:S:S170 8.83 0 No No 8 7 2 1
S:S:S170 X:X:?1 7.56 0 No Yes 7 0 1 0
S:S:I187 S:S:L322 2.85 7 Yes No 6 4 2 2
S:S:D190 S:S:Q193 3.92 0 No Yes 8 9 2 2
S:S:D190 S:S:Y218 8.05 0 No Yes 8 7 2 1
S:S:F270 S:S:Q193 3.51 2 Yes Yes 7 9 2 2
S:S:Q193 S:S:S296 2.89 2 Yes No 9 8 2 2
S:S:E297 S:S:Q193 3.82 0 No Yes 8 9 1 2
S:S:D216 S:S:Y218 3.45 2 No Yes 6 7 2 1
S:S:F270 S:S:Y218 4.13 2 Yes Yes 7 7 2 1
S:S:S296 S:S:Y218 6.36 2 No Yes 8 7 2 1
S:S:A298 S:S:Y218 4 2 No Yes 6 7 1 1
S:S:Y218 X:X:?1 21.07 2 Yes Yes 7 0 1 0
S:S:F270 S:S:S296 5.28 2 Yes No 7 8 2 2
S:S:E297 S:S:L322 13.25 0 No No 8 4 1 2
S:S:E297 X:X:?1 5.72 0 No Yes 8 0 1 0
S:S:A298 X:X:?1 6.8 2 No Yes 6 0 1 0
S:S:I416 X:X:?2 11.5 2 No Yes 4 0 2 2
S:S:S417 X:X:?2 6.91 2 Yes Yes 6 0 2 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:F684 S:S:S664 3.96 5 Yes No 8 6 1 2
S:S:E837 S:S:F668 13.99 5 No No 9 9 1 2
S:S:F668 S:S:I841 3.77 0 No No 9 9 2 2
S:S:P682 S:S:Q681 3.16 5 No Yes 5 9 2 1
S:S:Q681 S:S:W742 4.38 5 Yes Yes 9 9 1 2
S:S:E767 S:S:Q681 7.65 5 Yes Yes 7 9 2 1
S:S:L773 S:S:Q681 5.32 5 No Yes 8 9 1 1
S:S:Q681 X:X:?3 14.44 5 Yes Yes 9 0 1 0
S:S:P682 S:S:W742 4.05 5 No Yes 5 9 2 2
S:S:F684 S:S:F688 7.5 5 Yes Yes 8 8 1 2
S:S:F684 S:S:W818 4.01 5 Yes Yes 8 9 1 1
S:S:F684 S:S:I841 13.82 5 Yes No 8 9 1 2
S:S:F684 X:X:?3 16.04 5 Yes Yes 8 0 1 0
S:S:F688 S:S:F814 8.57 0 Yes Yes 8 9 2 2
S:S:Q735 S:S:V689 12.89 5 Yes No 9 7 2 2
S:S:T780 S:S:V689 3.17 5 No No 7 7 1 2
S:S:L776 S:S:Q735 7.99 0 No Yes 8 9 1 2
S:S:Q735 S:S:T780 2.83 5 Yes No 9 7 2 1
S:S:E767 S:S:W742 5.45 5 Yes Yes 7 9 2 2
S:S:I777 S:S:L773 5.71 5 Yes No 8 8 1 1
S:S:L773 X:X:?3 9.65 5 No Yes 8 0 1 0
S:S:L776 X:X:?3 3.22 0 No Yes 8 0 1 0
S:S:I777 X:X:?3 7.74 5 Yes Yes 8 0 1 0
S:S:T780 X:X:?3 4.57 5 No Yes 7 0 1 0
S:S:F814 S:S:W818 13.03 0 Yes Yes 9 9 2 1
S:S:F821 S:S:W818 10.02 5 Yes Yes 9 9 1 1
S:S:A840 S:S:W818 6.48 0 No Yes 9 9 2 1
S:S:W818 X:X:?3 12.36 5 Yes Yes 9 0 1 0
S:S:F821 S:S:Y825 8.25 5 Yes No 9 9 1 1
S:S:F821 S:S:V836 3.93 5 Yes No 9 8 1 2
S:S:E837 S:S:F821 8.16 5 No Yes 9 9 1 1
S:S:F821 X:X:?3 4.72 5 Yes Yes 9 0 1 0
S:S:V833 S:S:Y825 5.05 0 No No 6 9 2 1
S:S:Y825 X:X:?3 16.35 5 No Yes 9 0 1 0
S:S:E837 X:X:?3 19.51 5 No Yes 9 0 1 0
S:S:G778 S:S:I777 1.76 0 No Yes 5 8 2 1
S:S:C781 S:S:I777 1.64 0 No Yes 7 8 2 1
S:S:I738 S:S:L776 1.43 0 No No 8 8 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:R66 R:R:R69 5.33 1 Yes Yes 5 8 1 2
R:R:R66 R:R:W70 13 1 Yes Yes 5 5 1 2
R:R:R66 W:W:?1 5.24 1 Yes Yes 5 0 1 2
R:R:R66 W:W:?2 18.17 1 Yes Yes 5 0 1 2
L:L:?1 R:R:R66 8.93 0 No Yes 0 5 0 1
R:R:R69 W:W:?2 8.39 1 Yes Yes 8 0 2 2
R:R:W70 W:W:?1 3.28 1 Yes Yes 5 0 2 2
R:R:W70 W:W:?2 7.86 1 Yes Yes 5 0 2 2
R:R:G273 R:R:S302 3.71 3 No Yes 4 5 2 1
R:R:G273 R:R:I305 3.53 3 No Yes 4 4 2 2
R:R:L304 R:R:S302 3 3 Yes Yes 2 5 2 1
R:R:I305 R:R:S302 3.1 3 Yes Yes 4 5 2 1
L:L:?1 R:R:S302 5.52 0 No Yes 0 5 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P39 R:R:W70 4.05 1 Yes Yes 6 5 2 1
R:R:P39 R:R:T145 8.74 1 Yes Yes 6 5 2 1
R:R:R66 R:R:R69 5.33 1 Yes Yes 5 8 1 2
R:R:R66 R:R:W70 13 1 Yes Yes 5 5 1 1
R:R:R66 W:W:?1 5.24 1 Yes Yes 5 0 1 0
R:R:R66 W:W:?2 18.17 1 Yes Yes 5 0 1 2
L:L:?1 R:R:R66 8.93 0 No Yes 0 5 2 1
R:R:G67 R:R:W70 5.63 0 No Yes 4 5 2 1
R:R:R69 R:R:S417 5.27 1 Yes Yes 8 6 2 2
R:R:R69 W:W:?2 8.39 1 Yes Yes 8 0 2 2
R:R:T145 R:R:W70 6.06 1 Yes Yes 5 5 1 1
R:R:W70 R:R:Y167 2.89 1 Yes Yes 5 8 1 2
R:R:I416 R:R:W70 18.79 1 Yes Yes 4 5 1 1
R:R:S417 R:R:W70 4.94 1 Yes Yes 6 5 2 1
R:R:W70 W:W:?1 3.28 1 Yes Yes 5 0 1 0
R:R:W70 W:W:?2 7.86 1 Yes Yes 5 0 1 2
R:R:T145 R:R:Y167 4.99 1 Yes Yes 5 8 1 2
R:R:A168 R:R:T145 3.36 0 No Yes 5 5 2 1
R:R:T145 W:W:?1 4.24 1 Yes Yes 5 0 1 0
I:I:?3 R:R:T145 5.42 0 Yes Yes 0 5 2 1
R:R:S147 R:R:S169 3.26 0 No No 8 8 1 2
R:R:S147 R:R:S171 3.26 0 No No 8 7 1 2
R:R:S147 W:W:?1 6.48 0 No Yes 8 0 1 0
R:R:A168 R:R:I416 3.25 0 No Yes 5 4 2 1
R:R:I187 R:R:S170 4.64 1 Yes No 6 7 2 1
R:R:D190 R:R:S170 8.83 0 No No 8 7 2 1
R:R:S170 W:W:?1 7.56 0 No Yes 7 0 1 0
R:R:I187 R:R:L322 2.85 1 Yes No 6 4 2 2
R:R:D190 R:R:Q193 5.22 0 No Yes 8 9 2 2
R:R:D190 R:R:Y218 8.05 0 No Yes 8 7 2 1
R:R:Q193 R:R:S296 2.89 1 Yes No 9 8 2 2
R:R:E297 R:R:Q193 3.82 1 Yes Yes 8 9 1 2
R:R:D216 R:R:Y218 4.6 0 No Yes 6 7 2 1
R:R:G219 R:R:Y218 2.9 0 No Yes 7 7 2 1
R:R:S296 R:R:Y218 5.09 0 No Yes 8 7 2 1
R:R:A298 R:R:Y218 4 1 No Yes 6 7 1 1
R:R:Y218 W:W:?1 20.23 1 Yes Yes 7 0 1 0
R:R:E297 R:R:L322 9.28 1 Yes No 8 4 1 2
R:R:E297 R:R:I416 4.1 1 Yes Yes 8 4 1 1
R:R:E297 W:W:?1 12.39 1 Yes Yes 8 0 1 0
R:R:A298 W:W:?1 6.8 1 No Yes 6 0 1 0
R:R:I416 W:W:?1 3.08 1 Yes Yes 4 0 1 0
R:R:I416 W:W:?2 9.85 1 Yes Yes 4 0 1 2
R:R:S417 W:W:?2 5.18 1 Yes Yes 6 0 2 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F684 R:R:S664 5.28 12 Yes No 8 6 1 2
R:R:I841 R:R:S664 3.1 12 No No 9 6 2 2
R:R:E837 R:R:F668 9.33 12 No Yes 9 9 1 2
R:R:F668 R:R:I841 3.77 0 Yes No 9 9 2 2
R:R:Q681 R:R:W742 4.38 12 Yes Yes 9 9 1 2
R:R:E767 R:R:Q681 5.1 12 No Yes 7 9 2 1
R:R:L773 R:R:Q681 5.32 12 No Yes 8 9 2 1
R:R:Q681 W:W:?3 9.28 12 Yes Yes 9 0 1 0
R:R:F684 R:R:G685 3.01 12 Yes No 8 8 1 2
R:R:F684 R:R:F688 6.43 12 Yes Yes 8 8 1 2
R:R:F684 R:R:W818 4.01 12 Yes Yes 8 9 1 1
R:R:F684 R:R:I841 15.07 12 Yes No 8 9 1 2
R:R:F684 W:W:?3 14.16 12 Yes Yes 8 0 1 0
R:R:F688 R:R:F814 10.72 0 Yes Yes 8 9 2 1
R:R:E767 R:R:W742 3.27 12 No Yes 7 9 2 2
R:R:L773 R:R:W742 3.42 12 No Yes 8 9 2 2
R:R:I777 W:W:?3 17.69 0 No Yes 8 0 1 0
R:R:F814 R:R:T780 3.89 12 Yes No 9 7 1 1
R:R:T780 W:W:?3 7.99 12 No Yes 7 0 1 0
R:R:F814 R:R:F815 5.36 12 Yes No 9 7 1 2
R:R:F814 R:R:W818 12.03 12 Yes Yes 9 9 1 1
R:R:F814 W:W:?3 2.83 12 Yes Yes 9 0 1 0
R:R:A840 R:R:W818 7.78 0 No Yes 9 9 2 1
R:R:W818 W:W:?3 26.48 12 Yes Yes 9 0 1 0
R:R:I822 R:R:P823 3.39 0 No Yes 7 9 1 2
R:R:I822 W:W:?3 3.32 0 No Yes 7 0 1 0
R:R:V833 R:R:Y825 3.79 0 No No 6 9 2 1
R:R:E837 R:R:Y825 8.98 12 No No 9 9 1 1
R:R:Y825 W:W:?3 11.81 12 No Yes 9 0 1 0
R:R:E837 W:W:?3 12.32 12 No Yes 9 0 1 0
R:R:G774 R:R:I777 1.76 0 No No 4 8 2 1
R:R:G778 R:R:I777 1.76 0 No No 5 8 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9AVL_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.8
Number of Linked Nodes 1596
Number of Links 1999
Number of Hubs 336
Number of Links mediated by Hubs 1223
Number of Communities 56
Number of Nodes involved in Communities 529
Number of Links involved in Communities 752
Path Summary
Number Of Nodes in MetaPath 134
Number Of Links MetaPath 133
Number of Shortest Paths 9114784
Length Of Smallest Path 3
Average Path Length 38.59
Length of Longest Path 77
Minimum Path Strength 1.21
Average Path Strength 6.37835
Maximum Path Strength 32.615
Minimum Path Correlation 0.71
Average Path Correlation 0.998992
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.04082
Average % Of Corr. Nodes 62.8257
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.044
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • amino acid binding   • identical protein binding   • protein binding   • cation binding   • ion binding   • calcium ion binding   • metal ion binding   • small molecule binding   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • phosphoric ester hydrolase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • phospholipase C activity   • hydrolase activity   • phosphatidylinositol-4,5-bisphosphate phospholipase C activity   • catalytic activity   • phospholipase activity   • lipase activity   • transmembrane transporter binding   • cell adhesion molecule binding   • protein-containing complex binding   • integrin binding   • signaling receptor binding   • protein homodimerization activity   • protein dimerization activity   • kinase binding   • enzyme binding   • protein kinase binding   • biological regulation   • regulation of biological quality   • regulation of presynaptic membrane potential   • regulation of membrane potential   • regulation of calcium ion transport   • regulation of localization   • regulation of biological process   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • metal ion transport   • calcium ion transport   • localization
Gene OntologyBiological Process• biological regulation   • regulation of biological quality   • regulation of presynaptic membrane potential   • regulation of membrane potential   • regulation of calcium ion transport   • regulation of localization   • regulation of biological process   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • metal ion transport   • calcium ion transport   • localization   • monoatomic ion transport   • regulation of metal ion transport   • monoatomic cation transport   • developmental process   • multicellular organismal process   • epithelium development   • tube development   • branching morphogenesis of an epithelial tube   • morphogenesis of an epithelium   • tissue development   • tissue morphogenesis   • anatomical structure morphogenesis   • multicellular organism development   • tube morphogenesis   • morphogenesis of a branching structure   • anatomical structure development   • epithelial tube morphogenesis   • morphogenesis of a branching epithelium   • regulation of tube diameter   • system process   • regulation of tube size   • regulation of system process   • positive regulation of biological process   • positive regulation of vasoconstriction   • circulatory system process   • regulation of blood circulation   • vascular process in circulatory system   • regulation of vasoconstriction   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • blood vessel diameter maintenance   • vasoconstriction   • blood circulation   • regulation of anatomical structure size   • monoatomic ion transmembrane transport   • inorganic ion transmembrane transport   • inorganic anion transmembrane transport   • chloride transport   • transmembrane transport   • chloride transmembrane transport   • monoatomic anion transport   • monoatomic anion transmembrane transport   • cellular process   • inorganic anion transport   • regulation of biosynthetic process   • regulation of cellular process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • biosynthetic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • response to stimulus   • response to stress   • response to ischemia   • response to decreased oxygen levels   • cellular response to stimulus   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to chemical stimulus   • cellular response to stress   • response to hypoxia   • response to chemical   • response to oxygen levels   • response to abiotic stimulus   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • calcium ion homeostasis   • cellular homeostasis   • chemical homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis   • organic acid transport   • bile acid secretion   • organic anion transport   • monocarboxylic acid transport   • carboxylic acid transport   • secretion   • acid secretion   • response to peptide   • cellular response to peptide   • behavior   • chemosensory behavior   • signaling   • intracellular signal transduction   • cell communication   • JNK cascade   • intracellular signaling cassette   • MAPK cascade   • signal transduction   • cellular response to low-density lipoprotein particle stimulus   • response to endogenous stimulus   • response to lipoprotein particle   • response to nitrogen compound   • cellular response to lipoprotein particle stimulus   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • regulation of calcium ion import   • positive regulation of calcium ion transport   • positive regulation of calcium ion import   • positive regulation of transport   • positive regulation of monoatomic ion transport   • calcium ion import   • ossification   • connective tissue development   • adipose tissue development   • fat pad development   • animal organ development   • response to fibroblast growth factor   • response to growth factor   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • regulation of cell communication   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • response to oxygen-containing compound   • cellular response to glucose stimulus   • intracellular glucose homeostasis   • cellular response to oxygen-containing compound   • response to hexose   • cellular response to carbohydrate stimulus   • response to monosaccharide   • response to carbohydrate   • response to glucose   • glucose homeostasis   • carbohydrate homeostasis   • cellular response to hexose stimulus   • cellular response to monosaccharide stimulus   • response to nutrient levels   • response to lipid   • response to nutrient   • response to vitamin   • cellular response to vitamin D   • cellular response to nutrient levels   • response to vitamin D   • cellular response to vitamin   • cellular response to lipid   • cellular response to nutrient   • cell population proliferation   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • vasodilation   • positive chemotaxis   • chemotaxis   • positive regulation of locomotion   • regulation of response to external stimulus   • positive regulation of positive chemotaxis   • response to external stimulus   • regulation of chemotaxis   • positive regulation of chemotaxis   • regulation of positive chemotaxis   • positive regulation of response to external stimulus   • taxis   • regulation of locomotion   • locomotion   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • cellular response to endogenous stimulus   • response to hepatocyte growth factor   • cellular response to growth factor stimulus   • cellular response to hepatocyte growth factor stimulus   • protein localization   • establishment of protein localization   • nitrogen compound transport   • positive regulation of establishment of protein localization   • cellular macromolecule localization   • positive regulation of insulin secretion   • regulation of peptide hormone secretion   • regulation of hormone levels   • positive regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • protein secretion   • regulation of protein secretion   • regulation of secretion   • positive regulation of protein localization   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • positive regulation of secretion by cell   • hormone secretion   • protein localization to extracellular region   • positive regulation of protein transport   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • positive regulation of hormone secretion   • positive regulation of secretion   • amide transport   • signal release   • positive regulation of peptide secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • positive regulation of protein secretion   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • detection of stimulus   • response to metal ion   • detection of chemical stimulus   • detection of calcium ion   • response to calcium ion   • cell periphery   • presynapse   • cellular anatomical structure   • synapse   • cell junction   • membrane   • plasma membrane   • presynaptic membrane   • plasma membrane region   • synaptic membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • glutamatergic synapse
Gene OntologyCellular Component• cell periphery   • presynapse   • cellular anatomical structure   • synapse   • cell junction   • membrane   • plasma membrane   • presynaptic membrane   • plasma membrane region   • synaptic membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • glutamatergic synapse   • somatodendritic compartment   • cell body   • neuronal cell body   • apical part of cell   • apical plasma membrane   • cell surface   • axon   • neuron projection   • axon terminus   • plasma membrane bounded cell projection   • cell projection   • distal axon   • neuron projection terminus   • binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • GDP binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • cation binding   • metal ion binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cellular process   • cell division   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • regulation of molecular function   • negative regulation of lyase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • positive regulation of autophagy   • catabolic process   • macroautophagy   • autophagy   • positive regulation of biological process   • regulation of catabolic process   • regulation of autophagy   • positive regulation of catabolic process   • positive regulation of metabolic process   • regulation of macroautophagy   • metabolic process   • positive regulation of macroautophagy   • process utilizing autophagic mechanism   • regulation of metabolic process   • positive regulation of cellular process   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • nucleoside phosphate metabolic process   • ribose phosphate metabolic process   • purine nucleoside triphosphate metabolic process   • GTP metabolic process   • carbohydrate derivative metabolic process   • primary metabolic process   • nucleotide metabolic process   • purine-containing compound metabolic process   • nucleobase-containing compound metabolic process   • purine nucleotide metabolic process   • ribonucleotide metabolic process   • organophosphate metabolic process   • nucleobase-containing small molecule metabolic process   • purine ribonucleoside triphosphate metabolic process   • phosphate-containing compound metabolic process   • small molecule metabolic process   • nucleoside triphosphate metabolic process   • purine ribonucleotide metabolic process   • phosphorus metabolic process   • ribonucleoside triphosphate metabolic process   • midbody   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytoplasm   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • ciliary basal body   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • regulation of localization   • regulation of potassium ion transport   • transport   • monoatomic ion transmembrane transport   • potassium ion transmembrane transport   • regulation of monoatomic ion transmembrane transport   • metal ion transport   • monoatomic cation transmembrane transport   • localization   • monoatomic ion transport   • monoatomic cation transport   • regulation of metal ion transport   • regulation of transport   • regulation of monoatomic ion transport   • inorganic ion transmembrane transport   • regulation of potassium ion transmembrane transport   • establishment of localization   • inorganic cation transmembrane transport   • transmembrane transport   • regulation of transmembrane transport   • potassium ion transport   • regulation of monoatomic cation transmembrane transport   • anchoring junction   • focal adhesion   • cell-substrate junction   • perinuclear region of cytoplasm   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus
SCOP2Domain Identifier• TNF receptor-like   • Type 1 solute binding protein-like   • Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• TNF receptor-like   • Type 1 solute binding protein-like   • Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3 H:H:?4 H:H:?5 H:H:?6 H:H:?7 H:H:?8 H:H:?9 H:H:?10 H:H:?11 H:H:?12
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetyl-D-glucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

CodeTCR
PDB ResiduesX:X:?1 W:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeTCR
NameCYCLOMETHYLTRYPTOPHAN
Synonyms
Identifier
FormulaC12 H12 N2 O2
Molecular Weight216.236
SMILES
PubChem6920044
Formal Charge0
Total Atoms28
Total Chiral Atoms1
Total Bonds30
Total Aromatic Bonds10

CodePO4
PDB ResiduesX:X:?2 W:W:?2
Environment DetailsOpen EMBL-EBI Page
CodePO4
NamePhosphate ion
Synonyms
  • Phosphate
  • Phosphate ion
  • Orthophosphate
Identifier
FormulaO4 P
Molecular Weight94.971
SMILES
PubChem1061
Formal Charge-3
Total Atoms5
Total Chiral Atoms0
Total Bonds4
Total Aromatic Bonds0

CodeCA
PDB ResiduesI:I:?1 M:M:?1 I:I:?2 I:I:?3 L:L:?1 I:I:?4
Environment DetailsOpen EMBL-EBI Page
CodeCA
NameCALCIUM ION
Synonyms
Identifier
FormulaCa
Molecular Weight40.078
SMILES
PubChem
Formal Charge2
Total Atoms1
Total Chiral Atoms0
Total Bonds0
Total Aromatic Bonds0

Code9IG
PDB ResiduesX:X:?3 W:W:?3
Environment DetailsOpen EMBL-EBI Page
Code9IG
Name3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine
Synonyms
Identifier
FormulaC18 H22 Cl N O
Molecular Weight303.826
SMILES
PubChem158797
Formal Charge0
Total Atoms43
Total Chiral Atoms1
Total Bonds44
Total Aromatic Bonds12

PDBsumOpen PDBsum Page
ChainS
ProteinReceptor
UniProtP41180
Sequence
>9AVL_nogp_Chain_S
PDQRAQKKG DIILGGLFP IHFGVAAKD QDLKSRPES VECIRYNFR 
GFRWLQAMI FAIEEINSS PALLPNLTL GYRIFDTCN TVSKALEAT 
LSFVAQNKI DSLNCSEHI PSTIAVVGA TGSGVSTAV ANLLGLFYI 
PQVSYASSS RLLSNKNQF KSFLRTIPN DEHQATAMA DIIEYFRWN 
WVGTIAADD DYGRPGIEK FREEAEERD ICIDFSELI SQYSDEEEI 
QHVVEVIQN STAKVIVVF SSGPDLEPL IKEIVRRNI TGKIWLASE 
AWASSSLIA MPQYFHVVG GTIGFALKA GQIPGFREF LKKVHPRKS 
VHNGFAKEF WEETFNCHL PLCTGDENI SSVETPYID YTHLRISYN 
VYLAVYSIA HALQDIYTC LPGRGLFTN GSCADIKKV EAWQVLKHL 
RHLNFTNNM GEQVTFDEC GDLVGNYSI INWHLSPED GSIVFKEVG 
YYNVYAKKG ERLFINEEK ILWSGFSRE VPFSNCSRD CLAGTRKGI 
IEGEPTCCF ECVECPDGE YSDETDASA CNKCPDDFW SNENHTSCI 
AKEIEFLSW TEPFGIALT LFAVLGIFL TAFVLGVFI KFRNTPIVK 
ATNRELSYL LLFSLLCCF SSSLFFIGE PQDWTCRLR QPAFGISFV 
LCISCILVK TNRVLLVFE AKINLQFLL VFLCTFMQI VICVIWLYT 
APPSSYRNQ ELEDEIIFI TCHEGSLMA LGFLIGYTC LLAAICFFF 
AFKSRKLPE NFNEAKFIT FSMLIFFIV WISFIPAYA STYGKFVSA 
VEVIAILAA SFGLLACIF FNKIYIILF KPSRNTIEE VR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP41180
Sequence
>9AVL_nogp_Chain_R
GPDQRAQKK GDIILGGLF PIHFGVAAK DQDLKSRPE SVECIRYNF 
RGFRWLQAM IFAIEEINS SPALLPNLT LGYRIFDTC NTVSKALEA 
TLSFVAQNK IDSLNCSEH IPSTIAVVG ATGSGVSTA VANLLGLFY 
IPQVSYASS SRLLSNKNQ FKSFLRTIP NDEHQATAM ADIIEYFRW 
NWVGTIAAD DDYGRPGIE KFREEAEER DICIDFSEL ISQYSDEEE 
IQHVVEVIQ NSTAKVIVV FSSGPDLEP LIKEIVRRN ITGKIWLAS 
EAWASSSLI AMPQYFHVV GGTIGFALK AGQIPGFRE FLKKVHPRK 
SVHNGFAKE FWEETFNCH LRPLCTGDE NISSVETPY IDYTHLRIS 
YNVYLAVYS IAHALQDIY TCLPGRGLF TNGSCADIK KVEAWQVLK 
HLRHLNFTN NMGEQVTFD ECGDLVGNY SIINWHLSP EDGSIVFKE 
VGYYNVYAK KGERLFINE EKILWSGFS REVPFSNCS RDCLAGTRK 
GIIEGEPTC CFECVECPD GEYSDETDA SACNKCPDD FWSNENHTS 
CIAKEIEFL SWTEPFGIA LTLFAVLGI FLTAFVLGV FIKFRNTPI 
VKATNRELS YLLLFSLLC CFSSSLFFI GEPQDWTCR LRQPAFGIS 
FVLCISCIL VKTNRVLLV FEAKIPTSF HRKWWGLNL QFLLVFLCT 
FMQIVICVI WLYTAPPSS YRNQELEDE IIFITCHEG SLMALGFLI 
GYTCLLAAI CFFFAFKSR KLPENFNEA KFITFSMLI FFIVWISFI 
PAYASTYGK FVSAVEVIA ILAASFGLL ACIFFNKIY IILFKPSRN 
TIEEVRCST AAHAF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9C2FCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Tryptophan; '6218; PO4-2.82024-10-0210.1126/science.ado1868
9C1PCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan; '6218; PO4-2.82024-10-0210.1126/science.ado1868
9AXFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.52024-04-1710.1038/s41586-024-07331-1
9AXF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.52024-04-1710.1038/s41586-024-07331-1
9ASBCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs-CtGq)/β1/γ23.42024-04-1710.1038/s41586-024-07331-1
9ASB (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.42024-04-1710.1038/s41586-024-07331-1
9AVGCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4chim(NtGi1-Gs)/β1/γ23.62024-04-1710.1038/s41586-024-07331-1
9AVG (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-1710.1038/s41586-024-07331-1
9AYFCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4Gi1/β1/γ23.62024-04-1710.1038/s41586-024-07331-1
9AYF (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO43.62024-04-1710.1038/s41586-024-07331-1
9AVLCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO4Gi3/β2/γ23.82024-04-1710.1038/s41586-024-07331-1
9AVL (No Gprot) CIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; 9IG; PO43.82024-04-1710.1038/s41586-024-07331-1
8SZFCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-2.82024-02-0710.1038/s41586-024-07055-2
8SZGCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCWchim(NtGi1-Gq)/β1/γ23.62024-02-0710.1038/s41586-024-07055-2
8SZG (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW3.62024-02-0710.1038/s41586-024-07055-2
8SZHCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCWGi1/β1/γ23.12024-02-0710.1038/s41586-024-07055-2
8SZH (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW3.12024-02-0710.1038/s41586-024-07055-2
8SZICIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCWGi3/β1/γ23.52024-02-0710.1038/s41586-024-07055-2
8SZI (No Gprot) CIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW3.52024-02-0710.1038/s41586-024-07055-2
8WPGCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca-2.72023-11-2210.1038/s41422-023-00892-2
8WPUCIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Cachim(NtGi2L-Gs-CtGq)/β1/γ23.12023-11-2210.1038/s41422-023-00892-2
8WPU (No Gprot) CIonCalcium SensingCaSHomo sapiens-Tryptophan; Cinacalcet; PO4; Ca3.12023-11-2210.1038/s41422-023-00892-2
7SINCIonCalcium SensingCaSHomo sapiens-NPS-2143-5.92022-01-1910.1073/pnas.2115849118
7SIMCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-2.72022-01-1910.1073/pnas.2115849118
7SILCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-2.72022-01-1910.1073/pnas.2115849118
7E6UCIonCalcium SensingCaSHomo sapiens---62021-09-2210.7554/eLife.68578
7E6TCIonCalcium SensingCaSHomo sapiensCaCa; Ca; Cyclomethyltryptophan; PO4-32021-09-2210.7554/eLife.68578
7M3JCIonCalcium SensingCaSHomo sapiens-NPS-2143; PO4-4.12021-06-3010.1038/s41586-021-03691-0
7M3GCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4-2.52021-06-3010.1038/s41586-021-03691-0
7M3FCIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; Cinacalcet; PO4-2.82021-06-3010.1038/s41586-021-03691-0
7M3ECIonCalcium SensingCaSHomo sapiens-Ca; Ca; Tryptophan; NPS-2143-3.22021-06-3010.1038/s41586-021-03691-0
7DD7CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; Evocalcet-3.22021-06-1610.1126/sciadv.abg1483
7DD6CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan-3.22021-06-1610.1126/sciadv.abg1483
7DD5CIonCalcium SensingCaSGallus gallusCaCa; Ca; Tryptophan; NPS-2143-3.22021-06-1610.1126/sciadv.abg1483
7DTWCIonCalcium SensingCaSHomo sapiens---4.52021-03-1010.1038/s41422-021-00474-0
7DTVCIonCalcium SensingCaSHomo sapiensCaCa; Tryptophan-3.52021-03-1010.1038/s41422-021-00474-0
7DTUCIonCalcium SensingCaSHomo sapiens-Tryptophan-4.42021-03-1010.1038/s41422-021-00474-0
7DTTCIonCalcium SensingCaSHomo sapiensCaCa-3.82021-03-1010.1038/s41422-021-00474-0




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