| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 6W25 | A | Peptide | Melanocortin | MC4 | Homo sapiens | SHU9119 | Ca | - | 2.75 | 2020-04-29 | 10.1126/science.aaz8995 |
|
A 2D representation of the interactions of CA in 6W25
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?4 | R:R:L97 | 5.86 | 1 | Yes | No | 0 | 6 | 1 | 2 | | R:R:E100 | R:R:I125 | 9.56 | 1 | Yes | No | 5 | 5 | 1 | 2 | | R:R:D126 | R:R:E100 | 6.5 | 1 | Yes | Yes | 4 | 5 | 1 | 1 | | R:R:E100 | W:W:?100 | 9.73 | 1 | Yes | Yes | 5 | 0 | 1 | 0 | | L:L:?4 | R:R:E100 | 14.58 | 1 | Yes | Yes | 0 | 5 | 1 | 1 | | R:R:D122 | R:R:D126 | 10.65 | 1 | No | Yes | 8 | 4 | 1 | 1 | | R:R:D122 | W:W:?100 | 7.48 | 1 | No | Yes | 8 | 0 | 1 | 0 | | L:L:?1 | R:R:D122 | 16.68 | 0 | No | No | 0 | 8 | 2 | 1 | | R:R:D126 | W:W:?100 | 7.48 | 1 | Yes | Yes | 4 | 0 | 1 | 0 | | L:L:?4 | R:R:D126 | 16.08 | 1 | Yes | Yes | 0 | 4 | 1 | 1 | | L:L:R5 | R:R:D126 | 19.06 | 1 | Yes | Yes | 0 | 4 | 2 | 1 | | L:L:?4 | R:R:I129 | 19.32 | 1 | Yes | No | 0 | 5 | 1 | 2 | | L:L:?4 | R:R:C130 | 6.71 | 1 | Yes | Yes | 0 | 4 | 1 | 2 | | L:L:?4 | R:R:F261 | 14.43 | 1 | Yes | Yes | 0 | 5 | 1 | 2 | | L:L:?4 | R:R:L288 | 5.86 | 1 | Yes | No | 0 | 4 | 1 | 2 | | L:L:?4 | W:W:?100 | 10.75 | 1 | Yes | Yes | 0 | 0 | 1 | 0 | | L:L:?4 | L:L:R5 | 7.2 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | | L:L:?4 | L:L:W6 | 8.67 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | | L:L:R5 | L:L:W6 | 15.99 | 1 | Yes | Yes | 0 | 0 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 8.86 | | Average Nodes In Shell | 14.00 | | Average Hubs In Shell | 8.00 | | Average Links In Shell | 19.00 | | Average Links Mediated by Hubs In Shell | 18.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7DD5 | C | Ion | Calcium-sensing | CaS | Gallus gallus | Ca | Ca; Ca; Tryptophan; NPS-2143 | - | 3.2 | 2021-06-16 | 10.1126/sciadv.abg1483 |
|
A 2D representation of the interactions of CA in 7DD5
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | I:I:?1102 | R:R:D235 | 7.48 | 0 | No | No | 0 | 7 | 0 | 1 | | R:R:D235 | S:S:G557 | 1.68 | 0 | No | No | 7 | 5 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 7.48 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 2.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7DD5
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:R67 | R:R:R70 | 6.4 | 0 | No | No | 5 | 4 | 1 | 2 | | R:R:R67 | R:R:W71 | 12 | 0 | No | Yes | 5 | 5 | 1 | 2 | | L:L:?1103 | R:R:S303 | 5.51 | 0 | No | No | 0 | 1 | 0 | 1 | | L:L:?1103 | R:R:R67 | 2.23 | 0 | No | No | 0 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 3.87 | | Average Nodes In Shell | 5.00 | | Average Hubs In Shell | 1.00 | | Average Links In Shell | 4.00 | | Average Links Mediated by Hubs In Shell | 1.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7DD5
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:L38 | R:R:T101 | 4.42 | 0 | No | No | 7 | 7 | 2 | 1 | | R:R:P40 | R:R:W71 | 5.4 | 2 | Yes | Yes | 5 | 5 | 2 | 2 | | R:R:P40 | R:R:T146 | 12.24 | 2 | Yes | Yes | 5 | 4 | 2 | 1 | | R:R:T146 | R:R:W71 | 4.85 | 2 | Yes | Yes | 4 | 5 | 1 | 2 | | R:R:W71 | R:R:Y168 | 2.89 | 2 | Yes | Yes | 5 | 5 | 2 | 2 | | R:R:A108 | R:R:T101 | 3.36 | 0 | No | No | 5 | 7 | 2 | 1 | | I:I:?1104 | R:R:T101 | 8.12 | 0 | No | No | 0 | 7 | 0 | 1 | | R:R:A145 | R:R:V150 | 3.39 | 0 | No | No | 5 | 9 | 2 | 1 | | R:R:T146 | R:R:Y168 | 7.49 | 2 | Yes | Yes | 4 | 5 | 1 | 2 | | I:I:?1104 | R:R:T146 | 5.41 | 0 | No | Yes | 0 | 4 | 0 | 1 | | I:I:?1104 | R:R:V150 | 8.21 | 0 | No | No | 0 | 9 | 0 | 1 | | R:R:G147 | R:R:V150 | 1.84 | 0 | No | No | 8 | 9 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 7.25 | | Average Nodes In Shell | 11.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 12.00 | | Average Links Mediated by Hubs In Shell | 6.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7DD5
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | I:I:?1110 | S:S:D235 | 7.48 | 0 | No | No | 0 | 7 | 0 | 1 | | R:R:G557 | S:S:D235 | 1.68 | 0 | No | No | 5 | 7 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 7.48 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 2.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7DD5
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:F43 | S:S:R63 | 3.21 | 8 | Yes | Yes | 1 | 4 | 1 | 2 | | S:S:F43 | S:S:N65 | 19.33 | 8 | Yes | No | 1 | 1 | 1 | 2 | | S:S:F43 | S:S:P275 | 2.89 | 8 | Yes | No | 1 | 5 | 1 | 2 | | S:S:F43 | S:S:L305 | 9.74 | 8 | Yes | Yes | 1 | 4 | 1 | 2 | | M:M:?1102 | S:S:F43 | 4.47 | 0 | No | Yes | 0 | 1 | 0 | 1 | | S:S:L305 | S:S:R63 | 6.07 | 8 | Yes | Yes | 4 | 4 | 2 | 2 | | S:S:L305 | S:S:P275 | 3.28 | 8 | Yes | No | 4 | 5 | 2 | 2 | | S:S:L305 | S:S:S303 | 3 | 8 | Yes | No | 4 | 1 | 2 | 1 | | M:M:?1102 | S:S:S303 | 5.51 | 0 | No | No | 0 | 1 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 4.99 | | Average Nodes In Shell | 7.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 9.00 | | Average Links Mediated by Hubs In Shell | 8.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7DD5
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:L38 | S:S:T101 | 4.42 | 0 | Yes | No | 7 | 7 | 2 | 1 | | S:S:N65 | S:S:P40 | 3.26 | 0 | No | Yes | 1 | 5 | 2 | 1 | | S:S:N103 | S:S:P40 | 4.89 | 0 | No | Yes | 4 | 5 | 2 | 1 | | S:S:P40 | S:S:T146 | 12.24 | 1 | Yes | Yes | 5 | 4 | 1 | 1 | | I:I:?1103 | S:S:P40 | 6.03 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | S:S:T146 | S:S:W71 | 4.85 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | | S:S:W71 | S:S:Y168 | 2.89 | 1 | Yes | Yes | 5 | 5 | 2 | 2 | | S:S:A108 | S:S:T101 | 3.36 | 0 | No | No | 5 | 7 | 2 | 1 | | I:I:?1103 | S:S:T101 | 8.12 | 1 | Yes | No | 0 | 7 | 0 | 1 | | S:S:T146 | S:S:Y168 | 6.24 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | | I:I:?1103 | S:S:T146 | 5.41 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | S:S:G147 | S:S:V150 | 3.68 | 0 | No | No | 8 | 9 | 2 | 1 | | I:I:?1103 | S:S:V150 | 8.21 | 1 | Yes | No | 0 | 9 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 6.94 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 6.00 | | Average Links In Shell | 13.00 | | Average Links Mediated by Hubs In Shell | 11.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7DD6 | C | Ion | Calcium-sensing | CaS | Gallus gallus | Ca | Ca; Ca; Tryptophan | - | 3.2 | 2021-06-16 | 10.1126/sciadv.abg1483 |
|
A 2D representation of the interactions of CA in 7DD6
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | I:I:?1102 | R:R:D235 | 4.98 | 0 | No | No | 0 | 6 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 4.98 | | Average Nodes In Shell | 2.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 1.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7DD6
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:F43 | R:R:P275 | 5.78 | 2 | Yes | Yes | 3 | 4 | 2 | 1 | | R:R:F43 | R:R:L305 | 8.53 | 2 | Yes | No | 3 | 4 | 2 | 2 | | R:R:A169 | W:W:W1108 | 3.89 | 2 | No | Yes | 7 | 0 | 2 | 1 | | R:R:A299 | R:R:Y219 | 4 | 2 | No | Yes | 7 | 8 | 2 | 2 | | R:R:Y219 | W:W:W1108 | 3.86 | 2 | Yes | Yes | 8 | 0 | 2 | 1 | | R:R:G274 | R:R:S273 | 3.71 | 2 | Yes | No | 1 | 4 | 1 | 2 | | R:R:P275 | R:R:S273 | 5.34 | 2 | Yes | No | 4 | 4 | 1 | 2 | | R:R:G274 | R:R:P275 | 4.06 | 2 | Yes | Yes | 1 | 4 | 1 | 1 | | R:R:G274 | R:R:S303 | 3.71 | 2 | Yes | No | 1 | 3 | 1 | 1 | | L:L:?1103 | R:R:G274 | 3.14 | 2 | Yes | Yes | 0 | 1 | 0 | 1 | | R:R:L305 | R:R:P275 | 4.93 | 2 | No | Yes | 4 | 4 | 2 | 1 | | L:L:?1103 | R:R:P275 | 3.02 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:E298 | W:W:W1108 | 5.45 | 0 | No | Yes | 6 | 0 | 2 | 1 | | R:R:A299 | W:W:W1108 | 3.89 | 2 | No | Yes | 7 | 0 | 2 | 1 | | R:R:L305 | R:R:S303 | 3 | 2 | No | No | 4 | 3 | 2 | 1 | | L:L:?1103 | R:R:S303 | 5.51 | 2 | Yes | No | 0 | 3 | 0 | 1 | | L:L:?1103 | W:W:W1108 | 4.18 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 3.96 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 6.00 | | Average Links In Shell | 17.00 | | Average Links Mediated by Hubs In Shell | 16.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7DD6
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:L38 | R:R:T101 | 2.95 | 0 | No | No | 7 | 7 | 2 | 1 | | R:R:P40 | R:R:W71 | 5.4 | 2 | Yes | Yes | 4 | 4 | 2 | 2 | | R:R:P40 | R:R:T146 | 8.74 | 2 | Yes | Yes | 4 | 3 | 2 | 1 | | R:R:T146 | R:R:W71 | 3.64 | 2 | Yes | Yes | 3 | 4 | 1 | 2 | | R:R:W71 | R:R:Y168 | 2.89 | 2 | Yes | Yes | 4 | 5 | 2 | 2 | | R:R:D100 | R:R:T101 | 2.89 | 2 | Yes | No | 7 | 7 | 2 | 1 | | I:I:?1104 | R:R:T101 | 8.12 | 0 | No | No | 0 | 7 | 0 | 1 | | R:R:T146 | R:R:Y168 | 6.24 | 2 | Yes | Yes | 3 | 5 | 1 | 2 | | R:R:A169 | R:R:T146 | 3.36 | 2 | No | Yes | 7 | 3 | 2 | 1 | | I:I:?1104 | R:R:T146 | 2.71 | 0 | No | Yes | 0 | 3 | 0 | 1 | | R:R:G147 | R:R:V150 | 3.68 | 0 | No | No | 9 | 8 | 2 | 1 | | I:I:?1104 | R:R:V150 | 8.21 | 0 | No | No | 0 | 8 | 0 | 1 | | R:R:A169 | R:R:Y168 | 2.67 | 2 | No | Yes | 7 | 5 | 2 | 2 | | R:R:A108 | R:R:V150 | 1.7 | 0 | No | No | 6 | 8 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 6.35 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 14.00 | | Average Links Mediated by Hubs In Shell | 9.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7DD6
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:G557 | S:S:D235 | 5.03 | 40 | No | No | 5 | 7 | 1 | 1 | | I:I:?1105 | R:R:G557 | 3.14 | 40 | No | No | 0 | 5 | 0 | 1 | | I:I:?1105 | S:S:D235 | 7.48 | 40 | No | No | 0 | 7 | 0 | 1 | | R:R:E558 | R:R:G557 | 1.64 | 0 | No | No | 5 | 5 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 5.31 | | Average Nodes In Shell | 4.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 4.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7DD6
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:R67 | S:S:W71 | 7 | 1 | Yes | Yes | 4 | 4 | 2 | 2 | | S:S:R67 | X:X:W1108 | 3 | 1 | Yes | Yes | 4 | 0 | 2 | 1 | | S:S:W71 | X:X:W1108 | 2.81 | 1 | Yes | Yes | 4 | 0 | 2 | 1 | | S:S:A169 | X:X:W1108 | 5.19 | 0 | No | Yes | 7 | 0 | 2 | 1 | | S:S:A299 | S:S:Y219 | 4 | 1 | No | Yes | 7 | 8 | 2 | 2 | | S:S:Y219 | X:X:W1108 | 3.86 | 1 | Yes | Yes | 8 | 0 | 2 | 1 | | S:S:G274 | S:S:P275 | 4.06 | 1 | No | Yes | 1 | 5 | 1 | 2 | | S:S:G274 | S:S:S303 | 3.71 | 1 | No | No | 1 | 1 | 1 | 1 | | M:M:?1103 | S:S:G274 | 3.14 | 1 | No | No | 0 | 1 | 0 | 1 | | S:S:E298 | X:X:W1108 | 5.45 | 0 | No | Yes | 6 | 0 | 2 | 1 | | S:S:A299 | X:X:W1108 | 6.48 | 1 | No | Yes | 7 | 0 | 2 | 1 | | M:M:?1103 | S:S:S303 | 5.51 | 1 | No | No | 0 | 1 | 0 | 1 | | M:M:?1103 | X:X:W1108 | 4.18 | 1 | No | Yes | 0 | 0 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 4.28 | | Average Nodes In Shell | 11.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 13.00 | | Average Links Mediated by Hubs In Shell | 10.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7DD6
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:L38 | S:S:T101 | 5.9 | 0 | No | Yes | 7 | 7 | 2 | 1 | | S:S:N65 | S:S:P40 | 3.26 | 0 | No | Yes | 1 | 4 | 2 | 1 | | S:S:P40 | S:S:T101 | 3.5 | 1 | Yes | Yes | 4 | 7 | 1 | 1 | | S:S:P40 | S:S:T146 | 10.49 | 1 | Yes | Yes | 4 | 4 | 1 | 1 | | I:I:?1106 | S:S:P40 | 6.03 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | S:S:T146 | S:S:W71 | 3.64 | 1 | Yes | Yes | 4 | 4 | 1 | 2 | | S:S:D100 | S:S:T101 | 2.89 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | | S:S:A108 | S:S:T101 | 3.36 | 0 | No | Yes | 6 | 7 | 2 | 1 | | I:I:?1106 | S:S:T101 | 8.12 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | S:S:A145 | S:S:V150 | 3.39 | 0 | No | No | 5 | 9 | 2 | 1 | | S:S:T146 | S:S:Y168 | 12.48 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | | I:I:?1106 | S:S:T146 | 5.41 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | I:I:?1106 | S:S:V150 | 8.21 | 1 | Yes | No | 0 | 9 | 0 | 1 | | S:S:N103 | S:S:P40 | 1.63 | 0 | No | Yes | 4 | 4 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 6.94 | | Average Nodes In Shell | 13.00 | | Average Hubs In Shell | 7.00 | | Average Links In Shell | 14.00 | | Average Links Mediated by Hubs In Shell | 13.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7DD7 | C | Ion | Calcium-sensing | CaS | Gallus gallus | Ca | Ca; Ca; Tryptophan; Evocalcet | - | 3.2 | 2021-06-16 | 10.1126/sciadv.abg1483 |
|
A 2D representation of the interactions of CA in 7DD7
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:F43 | R:R:P275 | 5.78 | 1 | Yes | Yes | 3 | 4 | 2 | 1 | | R:R:F43 | R:R:L305 | 8.53 | 1 | Yes | No | 3 | 4 | 2 | 2 | | R:R:A169 | W:W:W1107 | 3.89 | 1 | No | Yes | 7 | 0 | 2 | 1 | | R:R:A299 | R:R:Y219 | 4 | 1 | No | Yes | 7 | 8 | 2 | 2 | | R:R:Y219 | W:W:W1107 | 3.86 | 1 | Yes | Yes | 8 | 0 | 2 | 1 | | R:R:G274 | R:R:S273 | 3.71 | 1 | Yes | No | 1 | 4 | 1 | 2 | | R:R:P275 | R:R:S273 | 5.34 | 1 | Yes | No | 4 | 4 | 1 | 2 | | R:R:G274 | R:R:P275 | 4.06 | 1 | Yes | Yes | 1 | 4 | 1 | 1 | | R:R:G274 | R:R:S303 | 3.71 | 1 | Yes | No | 1 | 3 | 1 | 1 | | L:L:?1102 | R:R:G274 | 3.14 | 1 | Yes | Yes | 0 | 1 | 0 | 1 | | R:R:L305 | R:R:P275 | 4.93 | 1 | No | Yes | 4 | 4 | 2 | 1 | | L:L:?1102 | R:R:P275 | 3.02 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:E298 | W:W:W1107 | 5.45 | 0 | No | Yes | 6 | 0 | 2 | 1 | | R:R:A299 | W:W:W1107 | 3.89 | 1 | No | Yes | 7 | 0 | 2 | 1 | | R:R:L305 | R:R:S303 | 3 | 1 | No | No | 4 | 3 | 2 | 1 | | L:L:?1102 | R:R:S303 | 5.51 | 1 | Yes | No | 0 | 3 | 0 | 1 | | L:L:?1102 | W:W:W1107 | 4.18 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 3.96 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 6.00 | | Average Links In Shell | 17.00 | | Average Links Mediated by Hubs In Shell | 16.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7DD7
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:L38 | R:R:T101 | 2.95 | 0 | No | No | 7 | 7 | 2 | 1 | | R:R:P40 | R:R:W71 | 5.4 | 1 | Yes | Yes | 4 | 4 | 2 | 2 | | R:R:P40 | R:R:T146 | 8.74 | 1 | Yes | Yes | 4 | 3 | 2 | 1 | | R:R:T146 | R:R:W71 | 3.64 | 1 | Yes | Yes | 3 | 4 | 1 | 2 | | R:R:W71 | R:R:Y168 | 2.89 | 1 | Yes | Yes | 4 | 5 | 2 | 2 | | R:R:D100 | R:R:T101 | 2.89 | 1 | Yes | No | 7 | 7 | 2 | 1 | | I:I:?1103 | R:R:T101 | 8.12 | 0 | No | No | 0 | 7 | 0 | 1 | | R:R:T146 | R:R:Y168 | 6.24 | 1 | Yes | Yes | 3 | 5 | 1 | 2 | | R:R:A169 | R:R:T146 | 3.36 | 1 | No | Yes | 7 | 3 | 2 | 1 | | I:I:?1103 | R:R:T146 | 2.71 | 0 | No | Yes | 0 | 3 | 0 | 1 | | R:R:G147 | R:R:V150 | 3.68 | 0 | No | No | 9 | 8 | 2 | 1 | | I:I:?1103 | R:R:V150 | 8.21 | 0 | No | No | 0 | 8 | 0 | 1 | | R:R:A169 | R:R:Y168 | 2.67 | 1 | No | Yes | 7 | 5 | 2 | 2 | | R:R:A108 | R:R:V150 | 1.7 | 0 | No | No | 6 | 8 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 6.35 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 14.00 | | Average Links Mediated by Hubs In Shell | 9.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7DD7
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | I:I:?1101 | R:R:D235 | 2.49 | 0 | No | No | 0 | 6 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 2.49 | | Average Nodes In Shell | 2.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 1.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7DD7
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:G557 | S:S:D235 | 5.03 | 43 | Yes | No | 5 | 7 | 1 | 1 | | I:I:?1106 | R:R:G557 | 3.14 | 43 | No | Yes | 0 | 5 | 0 | 1 | | I:I:?1106 | S:S:D235 | 7.48 | 43 | No | No | 0 | 7 | 0 | 1 | | R:R:E556 | R:R:G557 | 1.64 | 0 | No | Yes | 7 | 5 | 2 | 1 | | R:R:E558 | R:R:G557 | 1.64 | 0 | No | Yes | 5 | 5 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 5.31 | | Average Nodes In Shell | 5.00 | | Average Hubs In Shell | 1.00 | | Average Links In Shell | 5.00 | | Average Links Mediated by Hubs In Shell | 4.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7DD7
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:R67 | S:S:W71 | 7 | 2 | Yes | Yes | 5 | 5 | 2 | 2 | | S:S:R67 | X:X:W1109 | 3 | 2 | Yes | Yes | 5 | 0 | 2 | 1 | | S:S:W71 | X:X:W1109 | 2.81 | 2 | Yes | Yes | 5 | 0 | 2 | 1 | | S:S:A169 | X:X:W1109 | 5.19 | 0 | No | Yes | 7 | 0 | 2 | 1 | | S:S:A299 | S:S:Y219 | 4 | 2 | No | Yes | 7 | 8 | 2 | 2 | | S:S:Y219 | X:X:W1109 | 3.86 | 2 | Yes | Yes | 8 | 0 | 2 | 1 | | S:S:G274 | S:S:P275 | 4.06 | 2 | No | Yes | 1 | 5 | 1 | 2 | | S:S:G274 | S:S:S303 | 3.71 | 2 | No | No | 1 | 1 | 1 | 1 | | M:M:?1104 | S:S:G274 | 3.14 | 2 | No | No | 0 | 1 | 0 | 1 | | S:S:E298 | X:X:W1109 | 5.45 | 0 | No | Yes | 6 | 0 | 2 | 1 | | S:S:A299 | X:X:W1109 | 6.48 | 2 | No | Yes | 7 | 0 | 2 | 1 | | M:M:?1104 | S:S:S303 | 5.51 | 2 | No | No | 0 | 1 | 0 | 1 | | M:M:?1104 | X:X:W1109 | 4.18 | 2 | No | Yes | 0 | 0 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 4.28 | | Average Nodes In Shell | 11.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 13.00 | | Average Links Mediated by Hubs In Shell | 10.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7DD7
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:L38 | S:S:T101 | 5.9 | 0 | No | Yes | 7 | 7 | 2 | 1 | | S:S:N65 | S:S:P40 | 3.26 | 0 | No | Yes | 1 | 5 | 2 | 1 | | S:S:P40 | S:S:T101 | 3.5 | 2 | Yes | Yes | 5 | 7 | 1 | 1 | | S:S:P40 | S:S:T146 | 10.49 | 2 | Yes | Yes | 5 | 4 | 1 | 1 | | I:I:?1105 | S:S:P40 | 6.03 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | | S:S:T146 | S:S:W71 | 3.64 | 2 | Yes | Yes | 4 | 5 | 1 | 2 | | S:S:D100 | S:S:T101 | 2.89 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | | S:S:A108 | S:S:T101 | 3.36 | 0 | No | Yes | 5 | 7 | 2 | 1 | | I:I:?1105 | S:S:T101 | 8.12 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | | S:S:A145 | S:S:V150 | 3.39 | 0 | No | No | 5 | 9 | 2 | 1 | | S:S:T146 | S:S:Y168 | 12.48 | 2 | Yes | Yes | 4 | 5 | 1 | 2 | | I:I:?1105 | S:S:T146 | 5.41 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | I:I:?1105 | S:S:V150 | 8.21 | 2 | Yes | No | 0 | 9 | 0 | 1 | | S:S:N103 | S:S:P40 | 1.63 | 0 | No | Yes | 4 | 5 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 6.94 | | Average Nodes In Shell | 13.00 | | Average Hubs In Shell | 7.00 | | Average Links In Shell | 14.00 | | Average Links Mediated by Hubs In Shell | 13.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7DTT | C | Ion | Calcium-sensing | CaS | Homo sapiens | Ca | Ca | - | 3.8 | 2021-03-10 | 10.1038/s41422-021-00474-0 |
|
A 2D representation of the interactions of CA in 7DTT
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:L304 | R:R:S302 | 3 | 7 | Yes | No | 2 | 5 | 2 | 1 | | R:R:I305 | R:R:S302 | 3.1 | 7 | Yes | No | 4 | 5 | 2 | 1 | | L:L:?1101 | R:R:S302 | 5.51 | 0 | No | No | 0 | 5 | 0 | 1 | | R:R:I305 | R:R:L304 | 2.85 | 7 | Yes | Yes | 4 | 2 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 5.51 | | Average Nodes In Shell | 4.00 | | Average Hubs In Shell | 2.00 | | Average Links In Shell | 4.00 | | Average Links Mediated by Hubs In Shell | 3.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7DTT
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D234 | S:S:G557 | 3.35 | 22 | No | No | 5 | 6 | 1 | 1 | | I:I:?1102 | R:R:D234 | 9.97 | 22 | Yes | No | 0 | 5 | 0 | 1 | | R:R:G557 | S:S:D234 | 3.35 | 22 | No | No | 6 | 5 | 1 | 1 | | I:I:?1102 | R:R:G557 | 3.14 | 22 | Yes | No | 0 | 6 | 0 | 1 | | I:I:?1102 | S:S:D234 | 9.97 | 22 | Yes | No | 0 | 5 | 0 | 1 | | I:I:?1102 | S:S:G557 | 3.14 | 22 | Yes | No | 0 | 6 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 6.56 | | Average Nodes In Shell | 5.00 | | Average Hubs In Shell | 1.00 | | Average Links In Shell | 6.00 | | Average Links Mediated by Hubs In Shell | 4.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7DTT
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:L304 | S:S:S302 | 3 | 10 | Yes | No | 2 | 5 | 2 | 1 | | S:S:I305 | S:S:S302 | 3.1 | 10 | Yes | No | 4 | 5 | 2 | 1 | | M:M:?1101 | S:S:S302 | 5.51 | 0 | No | No | 0 | 5 | 0 | 1 | | S:S:I305 | S:S:L304 | 2.85 | 10 | Yes | Yes | 4 | 2 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 5.51 | | Average Nodes In Shell | 4.00 | | Average Hubs In Shell | 2.00 | | Average Links In Shell | 4.00 | | Average Links Mediated by Hubs In Shell | 3.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7DTV | C | Ion | Calcium-sensing | CaS | Homo sapiens | Ca | Ca; Tryptophan | - | 3.5 | 2021-03-10 | 10.1038/s41422-021-00474-0 |
|
A 2D representation of the interactions of CA in 7DTV
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:F42 | R:R:R62 | 8.55 | 32 | Yes | No | 3 | 4 | 1 | 2 | | R:R:F42 | R:R:N64 | 13.29 | 32 | Yes | Yes | 3 | 4 | 1 | 2 | | R:R:F42 | R:R:P274 | 7.22 | 32 | Yes | Yes | 3 | 3 | 1 | 2 | | R:R:F42 | R:R:L304 | 10.96 | 32 | Yes | No | 3 | 2 | 1 | 2 | | L:L:?1102 | R:R:F42 | 4.47 | 0 | No | Yes | 0 | 3 | 0 | 1 | | R:R:L304 | R:R:P274 | 3.28 | 32 | No | Yes | 2 | 3 | 2 | 2 | | L:L:?1102 | R:R:S302 | 5.51 | 0 | No | No | 0 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 4.99 | | Average Nodes In Shell | 7.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 7.00 | | Average Links Mediated by Hubs In Shell | 6.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7DTV
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D234 | S:S:G557 | 3.35 | 33 | No | No | 5 | 6 | 1 | 1 | | R:R:D234 | W:W:?1103 | 7.48 | 33 | No | No | 5 | 0 | 1 | 0 | | S:S:G557 | W:W:?1103 | 3.14 | 33 | No | No | 6 | 0 | 1 | 0 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 5.31 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 3.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7DTV
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:G557 | S:S:D234 | 3.35 | 39 | No | No | 6 | 5 | 1 | 1 | | R:R:G557 | X:X:?1108 | 3.14 | 39 | No | No | 6 | 0 | 1 | 0 | | S:S:D234 | X:X:?1108 | 7.48 | 39 | No | No | 5 | 0 | 1 | 0 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 5.31 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 3.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7DTV
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:F42 | S:S:R62 | 8.55 | 44 | Yes | No | 3 | 4 | 1 | 2 | | S:S:F42 | S:S:N64 | 13.29 | 44 | Yes | Yes | 3 | 4 | 1 | 2 | | S:S:F42 | S:S:P274 | 7.22 | 44 | Yes | Yes | 3 | 3 | 1 | 2 | | S:S:F42 | S:S:L304 | 10.96 | 44 | Yes | No | 3 | 2 | 1 | 2 | | M:M:?1102 | S:S:F42 | 4.47 | 0 | No | Yes | 0 | 3 | 0 | 1 | | S:S:L304 | S:S:P274 | 3.28 | 44 | No | Yes | 2 | 3 | 2 | 2 | | M:M:?1102 | S:S:S302 | 5.51 | 0 | No | No | 0 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 4.99 | | Average Nodes In Shell | 7.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 7.00 | | Average Links Mediated by Hubs In Shell | 6.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7E6T | C | Ion | Calcium-sensing | CaS | Homo sapiens | Ca | Ca; Ca; Cyclomethyltryptophan; PO4 | - | 3 | 2021-09-22 | 10.7554/eLife.68578 |
|
A 2D representation of the interactions of CA in 7E6T
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D190 | R:R:S170 | 11.78 | 1 | Yes | No | 8 | 7 | 1 | 1 | | L:L:?902 | R:R:S170 | 5.51 | 1 | Yes | No | 0 | 7 | 0 | 1 | | R:R:I187 | R:R:P188 | 3.39 | 0 | Yes | No | 6 | 8 | 1 | 2 | | R:R:I187 | R:R:L322 | 4.28 | 0 | Yes | No | 6 | 4 | 1 | 2 | | R:R:I187 | R:R:N419 | 4.25 | 0 | Yes | No | 6 | 7 | 1 | 2 | | L:L:?902 | R:R:I187 | 5.24 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | | R:R:D190 | R:R:N189 | 2.69 | 1 | Yes | No | 8 | 8 | 1 | 2 | | R:R:D190 | R:R:Q193 | 5.22 | 1 | Yes | Yes | 8 | 9 | 1 | 2 | | R:R:D190 | R:R:Y218 | 4.6 | 1 | Yes | Yes | 8 | 7 | 1 | 2 | | L:L:?902 | R:R:D190 | 4.98 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | R:R:F320 | R:R:Q193 | 10.54 | 1 | Yes | Yes | 6 | 9 | 2 | 2 | | R:R:Q193 | R:R:Y489 | 3.38 | 1 | Yes | No | 9 | 8 | 2 | 1 | | R:R:F320 | R:R:Y489 | 3.09 | 1 | Yes | No | 6 | 8 | 2 | 1 | | L:L:?902 | R:R:Y489 | 8.61 | 1 | Yes | No | 0 | 8 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 6.08 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 6.00 | | Average Links In Shell | 14.00 | | Average Links Mediated by Hubs In Shell | 14.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7E6T
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | I:I:?903 | R:R:D234 | 7.48 | 0 | No | No | 0 | 5 | 0 | 1 | | R:R:D234 | S:S:G557 | 1.68 | 0 | No | No | 5 | 6 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 7.48 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 2.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7E6T
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:L37 | R:R:T100 | 5.9 | 0 | No | No | 6 | 7 | 2 | 1 | | R:R:P39 | R:R:W70 | 5.4 | 1 | Yes | Yes | 6 | 5 | 1 | 2 | | R:R:N102 | R:R:P39 | 6.52 | 1 | No | Yes | 3 | 6 | 1 | 1 | | R:R:P39 | R:R:T145 | 5.25 | 1 | Yes | Yes | 6 | 5 | 1 | 1 | | R:R:P39 | R:R:Y167 | 2.78 | 1 | Yes | Yes | 6 | 8 | 1 | 2 | | I:I:?904 | R:R:P39 | 6.03 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | | R:R:T145 | R:R:W70 | 2.43 | 1 | Yes | Yes | 5 | 5 | 1 | 2 | | R:R:W70 | R:R:Y167 | 4.82 | 1 | Yes | Yes | 5 | 8 | 2 | 2 | | R:R:A107 | R:R:T100 | 3.36 | 0 | No | No | 7 | 7 | 2 | 1 | | I:I:?904 | R:R:T100 | 8.12 | 1 | Yes | No | 0 | 7 | 0 | 1 | | I:I:?904 | R:R:N102 | 2.52 | 1 | Yes | No | 0 | 3 | 0 | 1 | | R:R:A144 | R:R:S150 | 3.42 | 0 | No | No | 6 | 8 | 1 | 2 | | I:I:?904 | R:R:A144 | 2.89 | 1 | Yes | No | 0 | 6 | 0 | 1 | | R:R:T145 | R:R:Y167 | 6.24 | 1 | Yes | Yes | 5 | 8 | 1 | 2 | | R:R:A168 | R:R:T145 | 3.36 | 1 | No | Yes | 5 | 5 | 2 | 1 | | I:I:?904 | R:R:T145 | 2.71 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | R:R:T145 | W:W:?907 | 5.17 | 1 | Yes | Yes | 5 | 0 | 1 | 2 | | R:R:A168 | R:R:Y167 | 2.67 | 1 | No | Yes | 5 | 8 | 2 | 2 | | R:R:G146 | R:R:T145 | 1.82 | 0 | No | Yes | 5 | 5 | 2 | 1 | | R:R:A107 | R:R:V149 | 1.7 | 0 | No | No | 7 | 4 | 2 | 2 | | R:R:A144 | R:R:V149 | 1.7 | 0 | No | No | 6 | 4 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 4.45 | | Average Nodes In Shell | 15.00 | | Average Hubs In Shell | 6.00 | | Average Links In Shell | 21.00 | | Average Links Mediated by Hubs In Shell | 16.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7E6T
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:I187 | S:S:S170 | 4.64 | 2 | Yes | Yes | 6 | 7 | 1 | 1 | | S:S:D190 | S:S:S170 | 7.36 | 2 | No | Yes | 8 | 7 | 1 | 1 | | S:S:S170 | S:S:Y218 | 2.54 | 2 | Yes | Yes | 7 | 7 | 1 | 2 | | M:M:?902 | S:S:S170 | 5.51 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | | S:S:S170 | X:X:?907 | 4.21 | 2 | Yes | Yes | 7 | 0 | 1 | 2 | | S:S:I187 | S:S:R185 | 3.76 | 2 | Yes | Yes | 6 | 9 | 1 | 2 | | S:S:I187 | S:S:P188 | 3.39 | 2 | Yes | Yes | 6 | 8 | 1 | 2 | | S:S:I187 | S:S:L322 | 2.85 | 2 | Yes | Yes | 6 | 4 | 1 | 2 | | M:M:?902 | S:S:I187 | 5.24 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | | S:S:L322 | S:S:P188 | 3.28 | 2 | Yes | Yes | 4 | 8 | 2 | 2 | | S:S:P188 | S:S:Y489 | 6.95 | 2 | Yes | No | 8 | 8 | 2 | 1 | | S:S:D190 | S:S:Y218 | 6.9 | 2 | No | Yes | 8 | 7 | 1 | 2 | | M:M:?902 | S:S:D190 | 2.49 | 2 | Yes | No | 0 | 8 | 0 | 1 | | S:S:Q193 | S:S:S296 | 7.22 | 0 | Yes | No | 9 | 8 | 1 | 2 | | S:S:E297 | S:S:Q193 | 3.82 | 0 | No | Yes | 8 | 9 | 2 | 1 | | S:S:F320 | S:S:Q193 | 3.51 | 0 | Yes | Yes | 6 | 9 | 2 | 1 | | M:M:?902 | S:S:Q193 | 2.44 | 2 | Yes | Yes | 0 | 9 | 0 | 1 | | S:S:S296 | S:S:Y218 | 3.82 | 0 | No | Yes | 8 | 7 | 2 | 2 | | S:S:Y218 | X:X:?907 | 18.9 | 2 | Yes | Yes | 7 | 0 | 2 | 2 | | S:S:E297 | S:S:L322 | 7.95 | 0 | No | Yes | 8 | 4 | 2 | 2 | | S:S:E297 | X:X:?907 | 6.5 | 0 | No | Yes | 8 | 0 | 2 | 2 | | S:S:L322 | S:S:Y489 | 3.52 | 2 | Yes | No | 4 | 8 | 2 | 1 | | M:M:?902 | S:S:Y489 | 4.31 | 2 | Yes | No | 0 | 8 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 4.00 | | Average Nodes In Shell | 14.00 | | Average Hubs In Shell | 10.00 | | Average Links In Shell | 23.00 | | Average Links Mediated by Hubs In Shell | 23.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7E6T
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:G557 | S:S:D234 | 3.35 | 45 | No | No | 6 | 5 | 1 | 1 | | I:I:?905 | R:R:G557 | 3.14 | 45 | No | No | 0 | 6 | 0 | 1 | | I:I:?905 | S:S:D234 | 7.48 | 45 | No | No | 0 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 5.31 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 3.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7E6T
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:L37 | S:S:T100 | 4.42 | 0 | No | No | 6 | 7 | 2 | 1 | | S:S:P39 | S:S:W70 | 5.4 | 2 | No | Yes | 6 | 5 | 1 | 2 | | S:S:P39 | S:S:T145 | 12.24 | 2 | No | Yes | 6 | 5 | 1 | 1 | | I:I:?906 | S:S:P39 | 3.02 | 2 | Yes | No | 0 | 6 | 0 | 1 | | S:S:T145 | S:S:W70 | 3.64 | 2 | Yes | Yes | 5 | 5 | 1 | 2 | | S:S:W70 | S:S:Y167 | 5.79 | 2 | Yes | Yes | 5 | 8 | 2 | 2 | | I:I:?906 | S:S:T100 | 8.12 | 2 | Yes | No | 0 | 7 | 0 | 1 | | I:I:?906 | S:S:N102 | 2.52 | 2 | Yes | No | 0 | 3 | 0 | 1 | | S:S:A144 | S:S:V149 | 3.39 | 0 | No | No | 6 | 4 | 1 | 2 | | I:I:?906 | S:S:A144 | 2.89 | 2 | Yes | No | 0 | 6 | 0 | 1 | | S:S:T145 | S:S:Y167 | 2.5 | 2 | Yes | Yes | 5 | 8 | 1 | 2 | | I:I:?906 | S:S:T145 | 5.41 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | | S:S:G146 | S:S:T145 | 1.82 | 0 | No | Yes | 5 | 5 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 4.39 | | Average Nodes In Shell | 11.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 13.00 | | Average Links Mediated by Hubs In Shell | 11.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7M3E | C | Ion | Calcium-sensing | CaS | Homo sapiens | - | Ca; Ca; Tryptophan; NPS-2143; PO4 | - | 3.2 | 2021-06-30 | 10.1038/s41586-021-03691-0 |
|
A 2D representation of the interactions of CA in 7M3E
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:L431 | R:R:L88 | 5.54 | 0 | No | No | 8 | 9 | 2 | 1 | | R:R:L88 | R:R:Q432 | 3.99 | 0 | No | Yes | 9 | 7 | 1 | 2 | | I:I:?907 | R:R:L88 | 2.54 | 0 | No | No | 0 | 9 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 2.54 | | Average Nodes In Shell | 4.00 | | Average Hubs In Shell | 1.00 | | Average Links In Shell | 3.00 | | Average Links Mediated by Hubs In Shell | 1.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7M3E
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | I:I:?908 | R:R:D234 | 2.49 | 0 | No | No | 0 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 2.49 | | Average Nodes In Shell | 2.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 1.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7M3E
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | I:I:?909 | S:S:D234 | 2.49 | 0 | No | No | 0 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 2.49 | | Average Nodes In Shell | 2.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 1.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7M3E
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | I:I:?910 | S:S:S84 | 2.76 | 0 | No | No | 0 | 6 | 0 | 1 | | S:S:P85 | S:S:S84 | 1.78 | 0 | No | No | 3 | 6 | 2 | 1 | | S:S:L87 | S:S:S84 | 1.5 | 0 | Yes | No | 6 | 6 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 2.76 | | Average Nodes In Shell | 4.00 | | Average Hubs In Shell | 1.00 | | Average Links In Shell | 3.00 | | Average Links Mediated by Hubs In Shell | 1.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7M3F | C | Ion | Calcium-sensing | CaS | Homo sapiens | - | Ca; Ca; Tryptophan; Cinacalcet; PO4 | - | 2.8 | 2021-06-30 | 10.1038/s41586-021-03691-0 |
|
A 2D representation of the interactions of CA in 7M3F
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:L88 | R:R:L91 | 2.77 | 0 | Yes | Yes | 9 | 6 | 1 | 2 | | R:R:L88 | R:R:L93 | 2.77 | 0 | Yes | Yes | 9 | 9 | 1 | 2 | | R:R:L431 | R:R:L88 | 2.77 | 24 | No | Yes | 8 | 9 | 2 | 1 | | R:R:L88 | R:R:Q432 | 3.99 | 0 | Yes | No | 9 | 7 | 1 | 2 | | I:I:?907 | R:R:L88 | 2.54 | 0 | No | Yes | 0 | 9 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 2.54 | | Average Nodes In Shell | 6.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 5.00 | | Average Links Mediated by Hubs In Shell | 5.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7M3F
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:E558 | R:R:I555 | 4.1 | 3 | Yes | No | 5 | 5 | 1 | 2 | | R:R:E558 | R:R:P559 | 7.86 | 3 | Yes | No | 5 | 6 | 1 | 2 | | R:R:C562 | R:R:E558 | 4.56 | 3 | Yes | Yes | 9 | 5 | 2 | 1 | | R:R:C562 | R:R:P559 | 3.77 | 3 | Yes | No | 9 | 6 | 2 | 2 | | I:I:?908 | S:S:D234 | 2.49 | 0 | No | No | 0 | 5 | 0 | 1 | | I:I:?908 | R:R:E558 | 2.43 | 0 | No | Yes | 0 | 5 | 0 | 1 | | R:R:G557 | S:S:D234 | 1.68 | 0 | No | No | 6 | 5 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 2.46 | | Average Nodes In Shell | 7.00 | | Average Hubs In Shell | 2.00 | | Average Links In Shell | 7.00 | | Average Links Mediated by Hubs In Shell | 5.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7M3F
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D234 | S:S:G557 | 5.03 | 27 | No | No | 5 | 6 | 1 | 1 | | I:I:?909 | R:R:D234 | 7.48 | 27 | No | No | 0 | 5 | 0 | 1 | | I:I:?909 | S:S:G557 | 3.14 | 27 | No | No | 0 | 6 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 5.31 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 3.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7M3F
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | I:I:?910 | S:S:S84 | 2.76 | 0 | No | No | 0 | 6 | 0 | 1 | | S:S:L88 | S:S:L91 | 2.77 | 0 | Yes | No | 9 | 6 | 1 | 2 | | S:S:L431 | S:S:L88 | 4.15 | 0 | No | Yes | 8 | 9 | 2 | 1 | | S:S:L88 | S:S:Q432 | 2.66 | 0 | Yes | No | 9 | 7 | 1 | 2 | | I:I:?910 | S:S:L88 | 2.54 | 0 | No | Yes | 0 | 9 | 0 | 1 | | S:S:P85 | S:S:S84 | 1.78 | 0 | No | No | 3 | 6 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 2.65 | | Average Nodes In Shell | 7.00 | | Average Hubs In Shell | 1.00 | | Average Links In Shell | 6.00 | | Average Links Mediated by Hubs In Shell | 4.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7M3G | C | Ion | Calcium-sensing | CaS | Homo sapiens | - | Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4 | - | 2.5 | 2021-06-30 | 10.1038/s41586-021-03691-0 |
|
A 2D representation of the interactions of CA in 7M3G
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | |
| Statistics | Value |
|---|
| Average Number Of Links | 0.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 0.00 | | Average Nodes In Shell | 0.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 0.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7M3G
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:G557 | S:S:D234 | 3.35 | 45 | No | No | 6 | 5 | 1 | 1 | | I:I:?907 | R:R:G557 | 3.14 | 45 | No | No | 0 | 6 | 0 | 1 | | I:I:?907 | S:S:D234 | 7.48 | 45 | No | No | 0 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 5.31 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 3.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7M3G
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D234 | S:S:G557 | 5.03 | 0 | No | No | 5 | 6 | 1 | 2 | | I:I:?909 | R:R:D234 | 2.49 | 0 | No | No | 0 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 2.49 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 2.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7M3G
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:P85 | S:S:S84 | 3.56 | 0 | No | No | 3 | 6 | 2 | 1 | | I:I:?905 | S:S:S84 | 2.76 | 0 | No | No | 0 | 6 | 0 | 1 | | S:S:L87 | S:S:S84 | 1.5 | 0 | No | No | 6 | 6 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 2.76 | | Average Nodes In Shell | 4.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 3.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7SIL | C | Ion | Calcium-sensing | CaS | Homo sapiens | Ca | Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 | - | 2.7 | 2022-01-19 | 10.1073/pnas.2115849118 |
|
A 2D representation of the interactions of CA in 7SIL
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | |
| Statistics | Value |
|---|
| Average Number Of Links | 0.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 0.00 | | Average Nodes In Shell | 0.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 0.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7SIL
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:L37 | R:R:T100 | 5.9 | 0 | Yes | No | 6 | 7 | 2 | 1 | | R:R:F38 | R:R:P39 | 4.33 | 1 | Yes | Yes | 7 | 6 | 2 | 1 | | R:R:F38 | R:R:Y167 | 14.44 | 1 | Yes | Yes | 7 | 8 | 2 | 2 | | R:R:N64 | R:R:P39 | 3.26 | 0 | No | Yes | 4 | 6 | 2 | 1 | | R:R:P39 | R:R:W70 | 5.4 | 1 | Yes | Yes | 6 | 5 | 1 | 2 | | R:R:N102 | R:R:P39 | 6.52 | 0 | No | Yes | 3 | 6 | 2 | 1 | | R:R:P39 | R:R:T145 | 10.49 | 1 | Yes | Yes | 6 | 5 | 1 | 1 | | I:I:?2 | R:R:P39 | 9.05 | 1 | No | Yes | 0 | 6 | 0 | 1 | | R:R:T145 | R:R:W70 | 6.06 | 1 | Yes | Yes | 5 | 5 | 1 | 2 | | R:R:W70 | R:R:Y167 | 4.82 | 1 | Yes | Yes | 5 | 8 | 2 | 2 | | R:R:W70 | W:W:?2 | 6.39 | 1 | Yes | Yes | 5 | 0 | 2 | 2 | | R:R:A107 | R:R:T100 | 3.36 | 0 | No | No | 7 | 7 | 2 | 1 | | I:I:?2 | R:R:T100 | 8.12 | 1 | No | No | 0 | 7 | 0 | 1 | | R:R:T145 | R:R:Y167 | 9.99 | 1 | Yes | Yes | 5 | 8 | 1 | 2 | | R:R:A168 | R:R:T145 | 3.36 | 1 | No | Yes | 5 | 5 | 2 | 1 | | R:R:T145 | W:W:?2 | 5.17 | 1 | Yes | Yes | 5 | 0 | 1 | 2 | | I:I:?2 | R:R:T145 | 5.41 | 1 | No | Yes | 0 | 5 | 0 | 1 | | R:R:A168 | W:W:?2 | 3.31 | 1 | No | Yes | 5 | 0 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 7.53 | | Average Nodes In Shell | 13.00 | | Average Hubs In Shell | 7.00 | | Average Links In Shell | 18.00 | | Average Links Mediated by Hubs In Shell | 16.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7SIL
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:F42 | R:R:N64 | 20.54 | 32 | No | No | 3 | 4 | 1 | 2 | | R:R:F42 | R:R:L304 | 15.83 | 32 | No | Yes | 3 | 2 | 1 | 1 | | L:L:?3 | R:R:F42 | 4.47 | 32 | No | No | 0 | 3 | 0 | 1 | | R:R:L304 | R:R:R62 | 3.64 | 32 | Yes | No | 2 | 4 | 1 | 2 | | R:R:G273 | R:R:P274 | 4.06 | 0 | No | No | 4 | 3 | 2 | 2 | | R:R:G273 | R:R:S302 | 3.71 | 0 | No | No | 4 | 5 | 2 | 1 | | R:R:L304 | R:R:P274 | 4.93 | 32 | Yes | No | 2 | 3 | 1 | 2 | | L:L:?3 | R:R:S302 | 5.51 | 32 | No | No | 0 | 5 | 0 | 1 | | L:L:?3 | R:R:L304 | 5.08 | 32 | No | Yes | 0 | 2 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 5.02 | | Average Nodes In Shell | 8.00 | | Average Hubs In Shell | 1.00 | | Average Links In Shell | 9.00 | | Average Links Mediated by Hubs In Shell | 4.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7SIL
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:G557 | S:S:D234 | 5.03 | 0 | No | No | 6 | 5 | 1 | 2 | | I:I:?4 | R:R:G557 | 3.14 | 0 | No | No | 0 | 6 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 3.14 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 2.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7SIL
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | |
| Statistics | Value |
|---|
| Average Number Of Links | 0.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 0.00 | | Average Nodes In Shell | 0.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 0.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7SIL
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:L37 | S:S:T100 | 5.9 | 0 | Yes | No | 6 | 7 | 2 | 1 | | S:S:F38 | S:S:P39 | 4.33 | 2 | Yes | Yes | 7 | 6 | 2 | 1 | | S:S:F38 | S:S:Y167 | 14.44 | 2 | Yes | Yes | 7 | 8 | 2 | 2 | | S:S:N64 | S:S:P39 | 3.26 | 0 | No | Yes | 4 | 6 | 2 | 1 | | S:S:P39 | S:S:W70 | 5.4 | 2 | Yes | Yes | 6 | 5 | 1 | 2 | | S:S:N102 | S:S:P39 | 6.52 | 0 | No | Yes | 3 | 6 | 2 | 1 | | S:S:P39 | S:S:T145 | 10.49 | 2 | Yes | Yes | 6 | 5 | 1 | 1 | | I:I:?6 | S:S:P39 | 9.05 | 2 | No | Yes | 0 | 6 | 0 | 1 | | S:S:T145 | S:S:W70 | 6.06 | 2 | Yes | Yes | 5 | 5 | 1 | 2 | | S:S:W70 | S:S:Y167 | 4.82 | 2 | Yes | Yes | 5 | 8 | 2 | 2 | | S:S:W70 | X:X:?2 | 6.39 | 2 | Yes | Yes | 5 | 0 | 2 | 2 | | S:S:A107 | S:S:T100 | 3.36 | 0 | No | No | 7 | 7 | 2 | 1 | | I:I:?6 | S:S:T100 | 8.12 | 2 | No | No | 0 | 7 | 0 | 1 | | S:S:T145 | S:S:Y167 | 9.99 | 2 | Yes | Yes | 5 | 8 | 1 | 2 | | S:S:A168 | S:S:T145 | 3.36 | 2 | No | Yes | 5 | 5 | 2 | 1 | | S:S:T145 | X:X:?2 | 5.17 | 2 | Yes | Yes | 5 | 0 | 1 | 2 | | I:I:?6 | S:S:T145 | 5.41 | 2 | No | Yes | 0 | 5 | 0 | 1 | | S:S:A168 | X:X:?2 | 3.31 | 2 | No | Yes | 5 | 0 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 7.53 | | Average Nodes In Shell | 13.00 | | Average Hubs In Shell | 7.00 | | Average Links In Shell | 18.00 | | Average Links Mediated by Hubs In Shell | 16.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7SIL
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:F42 | S:S:N64 | 19.33 | 0 | No | No | 3 | 4 | 1 | 2 | | S:S:F42 | S:S:L304 | 17.05 | 0 | No | Yes | 3 | 2 | 1 | 2 | | M:M:?7 | S:S:F42 | 4.47 | 0 | No | No | 0 | 3 | 0 | 1 | | S:S:G273 | S:S:S302 | 3.71 | 3 | Yes | No | 4 | 5 | 2 | 1 | | S:S:G273 | S:S:L304 | 3.42 | 3 | Yes | Yes | 4 | 2 | 2 | 2 | | M:M:?7 | S:S:S302 | 5.51 | 0 | No | No | 0 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 4.99 | | Average Nodes In Shell | 6.00 | | Average Hubs In Shell | 2.00 | | Average Links In Shell | 6.00 | | Average Links Mediated by Hubs In Shell | 3.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7SIL
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D234 | S:S:G557 | 5.03 | 0 | No | No | 5 | 6 | 1 | 2 | | S:S:C236 | S:S:P559 | 3.77 | 0 | No | No | 9 | 6 | 2 | 1 | | S:S:E558 | S:S:P559 | 12.58 | 3 | Yes | No | 5 | 6 | 2 | 1 | | I:I:?8 | S:S:P559 | 3.02 | 0 | No | No | 0 | 6 | 0 | 1 | | I:I:?8 | R:R:D234 | 2.49 | 0 | No | No | 0 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 2.75 | | Average Nodes In Shell | 6.00 | | Average Hubs In Shell | 1.00 | | Average Links In Shell | 5.00 | | Average Links Mediated by Hubs In Shell | 1.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7SIM | C | Ion | Calcium-sensing | CaS | Homo sapiens | Ca | Ca; Ca; Cyclomethyltryptophan; PO4 | - | 2.7 | 2022-01-19 | 10.1073/pnas.2115849118 |
|
A 2D representation of the interactions of CA in 7SIM
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:L88 | R:R:L93 | 4.15 | 0 | Yes | No | 9 | 9 | 1 | 2 | | R:R:L431 | R:R:L88 | 5.54 | 0 | No | Yes | 8 | 9 | 2 | 1 | | R:R:L88 | R:R:Q432 | 3.99 | 0 | Yes | No | 9 | 7 | 1 | 2 | | I:I:?1 | R:R:L88 | 2.54 | 0 | No | Yes | 0 | 9 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 2.54 | | Average Nodes In Shell | 5.00 | | Average Hubs In Shell | 1.00 | | Average Links In Shell | 4.00 | | Average Links Mediated by Hubs In Shell | 4.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7SIM
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:L37 | R:R:T100 | 5.9 | 0 | Yes | No | 6 | 7 | 2 | 1 | | R:R:F38 | R:R:P39 | 4.33 | 1 | Yes | Yes | 7 | 6 | 2 | 1 | | R:R:F38 | R:R:Y167 | 17.54 | 1 | Yes | Yes | 7 | 8 | 2 | 2 | | R:R:P39 | R:R:W70 | 5.4 | 1 | Yes | Yes | 6 | 5 | 1 | 2 | | R:R:N102 | R:R:P39 | 6.52 | 0 | No | Yes | 3 | 6 | 2 | 1 | | R:R:P39 | R:R:T145 | 10.49 | 1 | Yes | Yes | 6 | 5 | 1 | 1 | | I:I:?2 | R:R:P39 | 9.05 | 1 | No | Yes | 0 | 6 | 0 | 1 | | R:R:T145 | R:R:W70 | 6.06 | 1 | Yes | Yes | 5 | 5 | 1 | 2 | | R:R:W70 | R:R:Y167 | 6.75 | 1 | Yes | Yes | 5 | 8 | 2 | 2 | | R:R:W70 | W:W:?1 | 5.59 | 1 | Yes | Yes | 5 | 0 | 2 | 2 | | I:I:?2 | R:R:T100 | 8.12 | 1 | No | No | 0 | 7 | 0 | 1 | | R:R:T145 | R:R:Y167 | 7.49 | 1 | Yes | Yes | 5 | 8 | 1 | 2 | | R:R:T145 | W:W:?1 | 5.17 | 1 | Yes | Yes | 5 | 0 | 1 | 2 | | I:I:?2 | R:R:T145 | 5.41 | 1 | No | Yes | 0 | 5 | 0 | 1 | | R:R:A107 | R:R:T100 | 3.36 | 0 | No | No | 7 | 7 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 7.53 | | Average Nodes In Shell | 11.00 | | Average Hubs In Shell | 7.00 | | Average Links In Shell | 15.00 | | Average Links Mediated by Hubs In Shell | 13.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7SIM
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:G273 | R:R:S302 | 3.71 | 0 | No | No | 4 | 5 | 2 | 1 | | L:L:?1 | R:R:S302 | 5.51 | 0 | No | No | 0 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 5.51 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 2.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7SIM
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:G557 | S:S:D234 | 5.03 | 0 | No | No | 6 | 5 | 2 | 1 | | I:I:?4 | S:S:D234 | 7.48 | 0 | No | No | 0 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 7.48 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 2.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7SIM
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:L88 | S:S:L93 | 4.15 | 0 | Yes | No | 9 | 9 | 1 | 2 | | S:S:L431 | S:S:L88 | 5.54 | 0 | No | Yes | 8 | 9 | 2 | 1 | | S:S:L88 | S:S:Q432 | 3.99 | 0 | Yes | No | 9 | 7 | 1 | 2 | | I:I:?5 | S:S:L88 | 2.54 | 0 | No | Yes | 0 | 9 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 2.54 | | Average Nodes In Shell | 5.00 | | Average Hubs In Shell | 1.00 | | Average Links In Shell | 4.00 | | Average Links Mediated by Hubs In Shell | 4.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7SIM
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:L37 | S:S:T100 | 5.9 | 0 | Yes | No | 6 | 7 | 2 | 1 | | S:S:F38 | S:S:P39 | 4.33 | 2 | Yes | Yes | 7 | 6 | 2 | 1 | | S:S:F38 | S:S:Y167 | 17.54 | 2 | Yes | Yes | 7 | 8 | 2 | 2 | | S:S:P39 | S:S:W70 | 5.4 | 2 | Yes | Yes | 6 | 5 | 1 | 2 | | S:S:N102 | S:S:P39 | 6.52 | 0 | No | Yes | 3 | 6 | 2 | 1 | | S:S:P39 | S:S:T145 | 10.49 | 2 | Yes | Yes | 6 | 5 | 1 | 1 | | I:I:?6 | S:S:P39 | 9.05 | 2 | No | Yes | 0 | 6 | 0 | 1 | | S:S:T145 | S:S:W70 | 6.06 | 2 | Yes | Yes | 5 | 5 | 1 | 2 | | S:S:W70 | S:S:Y167 | 6.75 | 2 | Yes | Yes | 5 | 8 | 2 | 2 | | S:S:W70 | X:X:?1 | 5.59 | 2 | Yes | Yes | 5 | 0 | 2 | 2 | | I:I:?6 | S:S:T100 | 8.12 | 2 | No | No | 0 | 7 | 0 | 1 | | S:S:T145 | S:S:Y167 | 9.99 | 2 | Yes | Yes | 5 | 8 | 1 | 2 | | S:S:T145 | X:X:?1 | 4.13 | 2 | Yes | Yes | 5 | 0 | 1 | 2 | | I:I:?6 | S:S:T145 | 5.41 | 2 | No | Yes | 0 | 5 | 0 | 1 | | S:S:A107 | S:S:T100 | 3.36 | 0 | No | No | 7 | 7 | 2 | 1 | | S:S:A168 | S:S:T145 | 3.36 | 0 | No | Yes | 5 | 5 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 7.53 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 7.00 | | Average Links In Shell | 16.00 | | Average Links Mediated by Hubs In Shell | 14.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7SIM
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:F42 | S:S:R62 | 4.28 | 39 | No | Yes | 3 | 4 | 2 | 2 | | S:S:F42 | S:S:L304 | 12.18 | 39 | No | Yes | 3 | 2 | 2 | 1 | | S:S:L304 | S:S:R62 | 7.29 | 39 | Yes | Yes | 2 | 4 | 1 | 2 | | S:S:G273 | S:S:P274 | 4.06 | 0 | No | Yes | 4 | 3 | 2 | 2 | | S:S:G273 | S:S:S302 | 3.71 | 0 | No | No | 4 | 5 | 2 | 1 | | S:S:L304 | S:S:P274 | 4.93 | 39 | Yes | Yes | 2 | 3 | 1 | 2 | | M:M:?1 | S:S:S302 | 5.51 | 0 | No | No | 0 | 5 | 0 | 1 | | M:M:?1 | S:S:L304 | 5.08 | 0 | No | Yes | 0 | 2 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 5.29 | | Average Nodes In Shell | 7.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 8.00 | | Average Links Mediated by Hubs In Shell | 6.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 7SIM
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D234 | S:S:G557 | 5.03 | 0 | No | No | 5 | 6 | 1 | 2 | | I:I:?8 | R:R:D234 | 7.48 | 0 | No | No | 0 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 7.48 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 2.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8GY7 | A | Peptide | Melanocortin | MC2 | Homo sapiens | Corticotropin | Ca | chim(NtGi1-Gs)/Beta1/Gamma2; MRAP1 | 3.3 | 2023-01-11 | 10.1038/s41422-022-00751-6 |
|
A 2D representation of the interactions of CA in 8GY7
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:M4 | R:R:E80 | 6.77 | 1 | Yes | Yes | 0 | 5 | 2 | 1 | | L:L:M4 | R:R:D103 | 6.93 | 1 | Yes | Yes | 0 | 9 | 2 | 1 | | L:L:R8 | R:R:D103 | 8.34 | 1 | Yes | Yes | 0 | 9 | 2 | 1 | | L:L:R8 | R:R:D107 | 17.87 | 1 | Yes | Yes | 0 | 4 | 2 | 1 | | R:R:E80 | R:R:Y76 | 10.1 | 1 | Yes | Yes | 5 | 5 | 1 | 2 | | R:R:I106 | R:R:Y76 | 6.04 | 1 | Yes | Yes | 5 | 5 | 2 | 2 | | R:R:D107 | R:R:Y76 | 8.05 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | | R:R:E80 | R:R:I84 | 8.2 | 1 | Yes | Yes | 5 | 4 | 1 | 2 | | R:R:D103 | R:R:E80 | 3.9 | 1 | Yes | Yes | 9 | 5 | 1 | 1 | | R:R:E80 | R:R:I106 | 5.47 | 1 | Yes | Yes | 5 | 5 | 1 | 2 | | I:I:?1 | R:R:E80 | 7.3 | 1 | No | Yes | 0 | 5 | 0 | 1 | | R:R:D103 | R:R:D107 | 10.65 | 1 | Yes | Yes | 9 | 4 | 1 | 1 | | I:I:?1 | R:R:D103 | 7.48 | 1 | No | Yes | 0 | 9 | 0 | 1 | | I:I:?1 | R:R:D107 | 9.97 | 1 | No | Yes | 0 | 4 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 8.25 | | Average Nodes In Shell | 9.00 | | Average Hubs In Shell | 8.00 | | Average Links In Shell | 14.00 | | Average Links Mediated by Hubs In Shell | 14.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8H8J | A | Orphan | A orphans | GPR35 | Homo sapiens | Lodoxamide | Ca | chim(NtGi1L-G13)/Beta1/Gamma2 | 3.2 | 2023-02-08 | 10.1038/s41421-022-00499-8 |
|
A 2D representation of the interactions of CA in 8H8J
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:R164 | R:R:T83 | 12.94 | 0 | No | No | 5 | 3 | 1 | 2 | | L:L:?1 | R:R:R164 | 8 | 1 | Yes | No | 0 | 5 | 2 | 1 | | H:H:?1 | R:R:R164 | 4.46 | 0 | No | No | 0 | 5 | 0 | 1 | | R:R:R240 | R:R:R255 | 15.99 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | | L:L:?1 | R:R:R240 | 3.55 | 1 | Yes | Yes | 0 | 5 | 2 | 2 | | R:R:L251 | R:R:R255 | 10.93 | 0 | No | Yes | 5 | 4 | 2 | 1 | | H:H:?1 | R:R:R255 | 8.92 | 0 | No | Yes | 0 | 4 | 0 | 1 | | R:R:I254 | R:R:R240 | 2.51 | 1 | No | Yes | 4 | 5 | 2 | 2 | | R:R:I254 | R:R:R255 | 2.51 | 1 | No | Yes | 4 | 4 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 6.69 | | Average Nodes In Shell | 8.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 9.00 | | Average Links Mediated by Hubs In Shell | 7.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8INR | A | Peptide | Melanocortin | MC5 | Homo Sapiens | Alpha-MSH | Ca | chim(NtGi1-Gs)/Beta1/Gamma2 | 2.73 | 2023-09-20 | 10.1038/s41421-023-00586-4 |
|
A 2D representation of the interactions of CA in 8INR
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:E92 | R:R:I96 | 6.83 | 5 | Yes | No | 6 | 4 | 1 | 2 | | R:R:E92 | R:R:F118 | 18.66 | 5 | Yes | Yes | 6 | 6 | 1 | 2 | | R:R:D119 | R:R:E92 | 7.8 | 5 | Yes | Yes | 4 | 6 | 1 | 1 | | L:L:M4 | R:R:E92 | 4.06 | 5 | No | Yes | 0 | 6 | 2 | 1 | | I:I:?1 | R:R:E92 | 7.3 | 5 | No | Yes | 0 | 6 | 0 | 1 | | L:L:M4 | R:R:I96 | 8.75 | 5 | No | No | 0 | 4 | 2 | 2 | | R:R:D115 | R:R:N116 | 6.73 | 5 | Yes | No | 8 | 4 | 1 | 2 | | R:R:D115 | R:R:D119 | 10.65 | 5 | Yes | Yes | 8 | 4 | 1 | 1 | | L:L:Y2 | R:R:D115 | 10.34 | 0 | Yes | Yes | 0 | 8 | 2 | 1 | | L:L:M4 | R:R:D115 | 8.32 | 5 | No | Yes | 0 | 8 | 2 | 1 | | L:L:R8 | R:R:D115 | 5.96 | 5 | Yes | Yes | 0 | 8 | 2 | 1 | | I:I:?1 | R:R:D115 | 7.48 | 5 | No | Yes | 0 | 8 | 0 | 1 | | L:L:R8 | R:R:N116 | 6.03 | 5 | Yes | No | 0 | 4 | 2 | 2 | | R:R:D119 | R:R:I178 | 4.2 | 5 | Yes | Yes | 4 | 4 | 1 | 2 | | L:L:F7 | R:R:D119 | 7.17 | 0 | No | Yes | 0 | 4 | 2 | 1 | | L:L:R8 | R:R:D119 | 20.25 | 5 | Yes | Yes | 0 | 4 | 2 | 1 | | I:I:?1 | R:R:D119 | 9.97 | 5 | No | Yes | 0 | 4 | 0 | 1 | | L:L:R8 | R:R:I178 | 16.28 | 5 | Yes | Yes | 0 | 4 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 8.25 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 7.00 | | Average Links In Shell | 18.00 | | Average Links Mediated by Hubs In Shell | 17.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8IOC | A | Peptide | Melanocortin | MC3 | Homo Sapiens | Gamma-MSH | Ca | chim(NtGi1-Gs)/Beta1/Gamma2 | 2.86 | 2023-09-20 | 10.1038/s41421-023-00586-4 |
|
A 2D representation of the interactions of CA in 8IOC
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D117 | R:R:E94 | 6.5 | 3 | Yes | Yes | 3 | 5 | 1 | 1 | | R:R:D121 | R:R:E94 | 9.09 | 3 | Yes | Yes | 4 | 5 | 1 | 1 | | R:R:E94 | R:R:I124 | 4.1 | 3 | Yes | Yes | 5 | 4 | 1 | 2 | | I:I:?1 | R:R:E94 | 7.3 | 3 | No | Yes | 0 | 5 | 0 | 1 | | R:R:D117 | R:R:D121 | 5.32 | 3 | Yes | Yes | 3 | 4 | 1 | 1 | | L:L:M3 | R:R:D117 | 9.7 | 0 | Yes | Yes | 0 | 3 | 2 | 1 | | I:I:?1 | R:R:D117 | 7.48 | 3 | No | Yes | 0 | 3 | 0 | 1 | | R:R:D121 | R:R:I180 | 4.2 | 3 | Yes | Yes | 4 | 5 | 1 | 2 | | L:L:F6 | R:R:D121 | 3.58 | 0 | Yes | Yes | 0 | 4 | 2 | 1 | | L:L:R7 | R:R:D121 | 11.91 | 3 | Yes | Yes | 0 | 4 | 2 | 1 | | I:I:?1 | R:R:D121 | 9.97 | 3 | No | Yes | 0 | 4 | 0 | 1 | | L:L:F6 | R:R:I124 | 12.56 | 0 | Yes | Yes | 0 | 4 | 2 | 2 | | L:L:R7 | R:R:I180 | 8.77 | 3 | Yes | Yes | 0 | 5 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 8.25 | | Average Nodes In Shell | 9.00 | | Average Hubs In Shell | 8.00 | | Average Links In Shell | 13.00 | | Average Links Mediated by Hubs In Shell | 13.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8IOD | A | Peptide | Melanocortin | MC5 | Homo Sapiens | PG-901 | Ca | chim(NtGi1-Gs)/Beta1/Gamma2 | 2.59 | 2023-09-20 | 10.1038/s41421-023-00586-4 |
|
A 2D representation of the interactions of CA in 8IOD
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?0 | L:L:?1 | 21.6 | 5 | Yes | Yes | 0 | 0 | 2 | 2 | | L:L:?0 | R:R:D115 | 16.29 | 5 | Yes | Yes | 0 | 8 | 2 | 1 | | L:L:?1 | R:R:I96 | 14.84 | 5 | Yes | Yes | 0 | 4 | 2 | 2 | | L:L:?1 | R:R:D115 | 16.68 | 5 | Yes | Yes | 0 | 8 | 2 | 1 | | L:L:?4 | L:L:R5 | 12.33 | 5 | Yes | Yes | 0 | 0 | 1 | 1 | | L:L:?4 | L:L:W6 | 6.75 | 5 | Yes | Yes | 0 | 0 | 1 | 2 | | L:L:?4 | R:R:E92 | 6.73 | 5 | Yes | Yes | 0 | 6 | 1 | 1 | | L:L:?4 | R:R:D119 | 9.19 | 5 | Yes | Yes | 0 | 4 | 1 | 1 | | L:L:?4 | R:R:I122 | 18.11 | 5 | Yes | Yes | 0 | 5 | 1 | 2 | | L:L:?4 | R:R:V126 | 6.3 | 5 | Yes | No | 0 | 6 | 1 | 2 | | L:L:?4 | R:R:F254 | 12.37 | 5 | Yes | Yes | 0 | 5 | 1 | 2 | | L:L:?4 | R:R:L281 | 4.68 | 5 | Yes | No | 0 | 3 | 1 | 2 | | I:I:?1 | L:L:?4 | 8.6 | 5 | Yes | Yes | 0 | 0 | 0 | 1 | | L:L:R5 | L:L:W6 | 4 | 5 | Yes | Yes | 0 | 0 | 1 | 2 | | L:L:R5 | R:R:N116 | 4.82 | 5 | Yes | No | 0 | 4 | 1 | 2 | | L:L:R5 | R:R:D119 | 19.06 | 5 | Yes | Yes | 0 | 4 | 1 | 1 | | L:L:R5 | R:R:I178 | 7.52 | 5 | Yes | Yes | 0 | 4 | 1 | 2 | | L:L:R5 | R:R:S181 | 9.22 | 5 | Yes | No | 0 | 2 | 1 | 2 | | I:I:?1 | L:L:R5 | 4.46 | 5 | Yes | Yes | 0 | 0 | 0 | 1 | | L:L:W6 | R:R:S181 | 6.18 | 5 | Yes | No | 0 | 2 | 2 | 2 | | R:R:E92 | R:R:I96 | 4.1 | 5 | Yes | Yes | 6 | 4 | 1 | 2 | | R:R:D115 | R:R:E92 | 3.9 | 5 | Yes | Yes | 8 | 6 | 1 | 1 | | R:R:E92 | R:R:F118 | 7 | 5 | Yes | Yes | 6 | 6 | 1 | 2 | | R:R:D119 | R:R:E92 | 9.09 | 5 | Yes | Yes | 4 | 6 | 1 | 1 | | R:R:E92 | R:R:I122 | 4.1 | 5 | Yes | Yes | 6 | 5 | 1 | 2 | | I:I:?1 | R:R:E92 | 7.3 | 5 | Yes | Yes | 0 | 6 | 0 | 1 | | R:R:D115 | R:R:D119 | 11.98 | 5 | Yes | Yes | 8 | 4 | 1 | 1 | | I:I:?1 | R:R:D115 | 7.48 | 5 | Yes | Yes | 0 | 8 | 0 | 1 | | R:R:I178 | R:R:N116 | 4.25 | 5 | Yes | No | 4 | 4 | 2 | 2 | | R:R:D119 | R:R:I178 | 4.2 | 5 | Yes | Yes | 4 | 4 | 1 | 2 | | I:I:?1 | R:R:D119 | 7.48 | 5 | Yes | Yes | 0 | 4 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 5.00 | | Average Interaction Strength | 7.06 | | Average Nodes In Shell | 18.00 | | Average Hubs In Shell | 14.00 | | Average Links In Shell | 31.00 | | Average Links Mediated by Hubs In Shell | 31.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8SZF | C | Ion | Calcium-sensing | CaS | Homo sapiens | - | Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW | - | 2.8 | 2024-02-07 | 10.1038/s41586-024-07055-2 |
|
A 2D representation of the interactions of CA in 8SZF
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:L88 | R:R:L91 | 2.77 | 0 | Yes | No | 9 | 6 | 1 | 2 | | R:R:L431 | R:R:L88 | 5.54 | 34 | No | Yes | 8 | 9 | 2 | 1 | | R:R:L88 | R:R:Q432 | 3.99 | 0 | Yes | Yes | 9 | 7 | 1 | 2 | | R:R:L88 | W:W:?2 | 2.54 | 0 | Yes | No | 9 | 0 | 1 | 0 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 2.54 | | Average Nodes In Shell | 5.00 | | Average Hubs In Shell | 2.00 | | Average Links In Shell | 4.00 | | Average Links Mediated by Hubs In Shell | 4.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 8SZF
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:P559 | R:R:W208 | 2.7 | 3 | No | Yes | 6 | 9 | 1 | 2 | | R:R:E558 | R:R:I555 | 4.1 | 3 | Yes | No | 5 | 5 | 1 | 2 | | R:R:E558 | R:R:P559 | 3.14 | 3 | Yes | No | 5 | 6 | 1 | 1 | | R:R:E558 | W:W:?3 | 7.3 | 3 | Yes | No | 5 | 0 | 1 | 0 | | R:R:P559 | W:W:?3 | 3.02 | 3 | No | No | 6 | 0 | 1 | 0 | | R:R:E558 | R:R:G557 | 1.64 | 3 | Yes | No | 5 | 6 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 5.16 | | Average Nodes In Shell | 6.00 | | Average Hubs In Shell | 2.00 | | Average Links In Shell | 6.00 | | Average Links Mediated by Hubs In Shell | 5.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 8SZF
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D234 | W:W:?4 | 7.48 | 0 | No | No | 5 | 0 | 1 | 0 | | S:S:G557 | W:W:?4 | 3.14 | 0 | No | No | 6 | 0 | 1 | 0 | | S:S:E558 | S:S:G557 | 1.64 | 0 | No | No | 5 | 6 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 5.31 | | Average Nodes In Shell | 4.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 3.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 8SZF
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | |
| Statistics | Value |
|---|
| Average Number Of Links | 0.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 0.00 | | Average Nodes In Shell | 0.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 0.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8SZG | C | Ion | Calcium-sensing | CaS | Homo sapiens | - | Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW | chim(NtGi1-Gq)/Beta1/Gamma2 | 3.6 | 2024-02-07 | 10.1038/s41586-024-07055-2 |
|
A 2D representation of the interactions of CA in 8SZG
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | |
| Statistics | Value |
|---|
| Average Number Of Links | 0.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 0.00 | | Average Nodes In Shell | 0.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 0.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 8SZG
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D234 | S:S:G557 | 1.68 | 56 | No | No | 5 | 6 | 1 | 1 | | R:R:D234 | W:W:?4 | 7.48 | 56 | No | No | 5 | 0 | 1 | 0 | | S:S:E558 | S:S:G557 | 3.27 | 0 | No | No | 5 | 6 | 2 | 1 | | S:S:G557 | W:W:?4 | 3.14 | 56 | No | No | 6 | 0 | 1 | 0 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 5.31 | | Average Nodes In Shell | 4.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 4.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 8SZG
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:G557 | S:S:D234 | 5.03 | 0 | No | No | 6 | 5 | 2 | 1 | | S:S:D234 | W:W:?7 | 2.49 | 0 | No | No | 5 | 0 | 1 | 0 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 2.49 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 2.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8SZH | C | Ion | Calcium-sensing | CaS | Homo sapiens | - | Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW | Gi1/Beta1/Gamma2 | 3.1 | 2024-02-07 | 10.1038/s41586-024-07055-2 |
|
A 2D representation of the interactions of CA in 8SZH
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:L88 | R:R:P89 | 1.64 | 1 | Yes | No | 9 | 8 | 1 | 2 | | R:R:A428 | R:R:L88 | 1.58 | 1 | No | Yes | 9 | 9 | 2 | 1 | | R:R:L431 | R:R:L88 | 5.54 | 1 | No | Yes | 8 | 9 | 2 | 1 | | R:R:L88 | R:R:Q432 | 5.32 | 1 | Yes | Yes | 9 | 7 | 1 | 2 | | R:R:L88 | W:W:?3 | 2.54 | 1 | Yes | No | 9 | 0 | 1 | 0 | | R:R:P89 | R:R:Q432 | 1.58 | 1 | No | Yes | 8 | 7 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 2.54 | | Average Nodes In Shell | 6.00 | | Average Hubs In Shell | 2.00 | | Average Links In Shell | 6.00 | | Average Links Mediated by Hubs In Shell | 6.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 8SZH
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D234 | W:W:?4 | 7.48 | 0 | No | No | 5 | 0 | 1 | 0 | | S:S:G557 | W:W:?4 | 3.14 | 0 | No | No | 6 | 0 | 1 | 0 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 5.31 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 2.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 8SZH
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | |
| Statistics | Value |
|---|
| Average Number Of Links | 0.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 0.00 | | Average Nodes In Shell | 0.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 0.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 8SZH
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:G557 | S:S:D234 | 5.03 | 0 | No | No | 6 | 5 | 2 | 1 | | K:K:?4 | S:S:D234 | 7.48 | 0 | No | No | 0 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 7.48 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 2.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8SZI | C | Ion | Calcium-sensing | CaS | Homo sapiens | - | Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW | Gi3/Beta1/Gamma2 | 3.5 | 2024-02-07 | 10.1038/s41586-024-07055-2 |
|
A 2D representation of the interactions of CA in 8SZI
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:L431 | R:R:L88 | 5.54 | 55 | No | No | 8 | 9 | 2 | 1 | | R:R:L88 | R:R:Q432 | 3.99 | 0 | No | No | 9 | 7 | 1 | 2 | | R:R:L88 | W:W:?2 | 2.54 | 0 | No | No | 9 | 0 | 1 | 0 | | R:R:P89 | R:R:Y435 | 4.17 | 0 | No | No | 8 | 3 | 1 | 2 | | R:R:P89 | W:W:?2 | 3.02 | 0 | No | No | 8 | 0 | 1 | 0 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 2.78 | | Average Nodes In Shell | 6.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 5.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 8SZI
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D234 | W:W:?3 | 7.48 | 0 | No | No | 5 | 0 | 1 | 0 | | S:S:G557 | W:W:?3 | 3.14 | 0 | No | No | 6 | 0 | 1 | 0 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 5.31 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 2.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 8SZI
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:L93 | S:S:N82 | 4.12 | 0 | No | No | 9 | 9 | 2 | 1 | | K:K:?2 | S:S:N82 | 2.52 | 0 | No | No | 0 | 9 | 0 | 1 | | S:S:L431 | S:S:L88 | 4.15 | 0 | No | No | 8 | 9 | 2 | 1 | | K:K:?2 | S:S:L88 | 2.54 | 0 | No | No | 0 | 9 | 0 | 1 | | S:S:L88 | S:S:P89 | 1.64 | 0 | No | No | 9 | 8 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 2.53 | | Average Nodes In Shell | 6.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 5.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 8SZI
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:G557 | S:S:D234 | 5.03 | 62 | No | No | 6 | 5 | 1 | 1 | | K:K:?3 | R:R:G557 | 3.14 | 62 | No | No | 0 | 6 | 0 | 1 | | K:K:?3 | S:S:D234 | 9.97 | 62 | No | No | 0 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 6.56 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 3.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8WPG | C | Ion | Calcium-sensing | CaS | Homo sapiens | - | Tryptophan; Cinacalcet; PO4; Ca | - | 2.7 | 2023-11-22 | 10.1038/s41422-023-00892-2 |
|
A 2D representation of the interactions of CA in 8WPG
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:L431 | S:S:L88 | 5.54 | 0 | No | No | 8 | 9 | 2 | 1 | | S:S:L88 | X:X:?2 | 2.54 | 0 | No | No | 9 | 0 | 1 | 0 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 2.54 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 2.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 8WPG
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:E558 | S:S:I555 | 5.47 | 4 | Yes | No | 5 | 5 | 1 | 2 | | S:S:E558 | S:S:P559 | 4.72 | 4 | Yes | Yes | 5 | 6 | 1 | 2 | | S:S:C562 | S:S:E558 | 4.56 | 4 | Yes | Yes | 9 | 5 | 2 | 1 | | S:S:C562 | S:S:P559 | 3.77 | 4 | Yes | Yes | 9 | 6 | 2 | 2 | | I:I:?1 | S:S:G557 | 3.14 | 0 | No | No | 0 | 6 | 0 | 1 | | I:I:?1 | R:R:D234 | 2.49 | 0 | No | No | 0 | 5 | 0 | 1 | | I:I:?1 | S:S:E558 | 2.43 | 0 | No | Yes | 0 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 2.69 | | Average Nodes In Shell | 7.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 7.00 | | Average Links Mediated by Hubs In Shell | 5.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 8WPG
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:G557 | S:S:D234 | 5.03 | 0 | No | No | 6 | 5 | 2 | 1 | | I:I:?2 | S:S:D234 | 7.48 | 0 | No | No | 0 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 7.48 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 2.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 8WPG
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:L87 | R:R:L88 | 4.15 | 2 | Yes | No | 6 | 9 | 1 | 1 | | R:R:L87 | R:R:Y425 | 3.52 | 2 | Yes | Yes | 6 | 8 | 1 | 2 | | R:R:H429 | R:R:L87 | 3.86 | 2 | No | Yes | 6 | 6 | 2 | 1 | | R:R:L431 | R:R:L88 | 4.15 | 0 | No | No | 8 | 9 | 2 | 1 | | R:R:H429 | R:R:Y425 | 4.36 | 2 | No | Yes | 6 | 8 | 2 | 2 | | R:R:S84 | W:W:?2 | 2.76 | 0 | No | No | 6 | 0 | 1 | 0 | | R:R:L87 | W:W:?2 | 2.54 | 2 | Yes | No | 6 | 0 | 1 | 0 | | R:R:L88 | W:W:?2 | 2.54 | 2 | No | No | 9 | 0 | 1 | 0 | | R:R:P85 | R:R:S84 | 1.78 | 0 | No | No | 3 | 6 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 2.61 | | Average Nodes In Shell | 8.00 | | Average Hubs In Shell | 2.00 | | Average Links In Shell | 9.00 | | Average Links Mediated by Hubs In Shell | 5.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8WPU | C | Ion | Calcium-sensing | CaS | Homo sapiens | - | Tryptophan; Cinacalcet; PO4; Ca | chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 | 3.1 | 2023-11-22 | 10.1038/s41422-023-00892-2 |
|
A 2D representation of the interactions of CA in 8WPU
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:P85 | S:S:S84 | 3.56 | 0 | No | No | 3 | 6 | 1 | 2 | | S:S:P85 | X:X:?3 | 3.02 | 0 | No | No | 3 | 0 | 1 | 0 | | S:S:P89 | S:S:Y435 | 6.95 | 0 | No | No | 8 | 3 | 1 | 2 | | S:S:P89 | X:X:?3 | 3.02 | 0 | No | No | 8 | 0 | 1 | 0 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 3.02 | | Average Nodes In Shell | 5.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 4.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 8WPU
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:E558 | S:S:I555 | 5.47 | 0 | No | No | 5 | 5 | 1 | 2 | | S:S:E556 | S:S:G557 | 3.27 | 0 | No | No | 6 | 6 | 2 | 1 | | R:R:D234 | S:S:G557 | 5.03 | 41 | No | No | 5 | 6 | 1 | 1 | | I:I:?2 | S:S:G557 | 3.14 | 41 | No | No | 0 | 6 | 0 | 1 | | S:S:E558 | S:S:P559 | 6.29 | 0 | No | Yes | 5 | 6 | 1 | 2 | | I:I:?2 | S:S:E558 | 2.43 | 41 | No | No | 0 | 5 | 0 | 1 | | I:I:?2 | R:R:D234 | 7.48 | 41 | No | No | 0 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 4.35 | | Average Nodes In Shell | 7.00 | | Average Hubs In Shell | 1.00 | | Average Links In Shell | 7.00 | | Average Links Mediated by Hubs In Shell | 1.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 8WPU
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:G557 | S:S:D234 | 5.03 | 37 | No | No | 6 | 5 | 1 | 1 | | I:I:?1 | S:S:D234 | 7.48 | 37 | No | No | 0 | 5 | 0 | 1 | | I:I:?1 | R:R:G557 | 3.14 | 37 | No | No | 0 | 6 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 5.31 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 3.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 8WPU
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:P85 | R:R:S84 | 3.56 | 0 | No | No | 3 | 6 | 1 | 2 | | R:R:P85 | W:W:?3 | 3.02 | 0 | No | Yes | 3 | 0 | 1 | 0 | | R:R:H429 | R:R:L87 | 10.29 | 0 | No | No | 6 | 6 | 2 | 1 | | R:R:L87 | R:R:Q432 | 2.66 | 0 | No | Yes | 6 | 7 | 1 | 2 | | R:R:L87 | W:W:?3 | 2.54 | 0 | No | Yes | 6 | 0 | 1 | 0 | | R:R:L88 | R:R:L91 | 9.69 | 0 | Yes | No | 9 | 6 | 1 | 2 | | R:R:L88 | R:R:L93 | 2.77 | 0 | Yes | Yes | 9 | 9 | 1 | 2 | | R:R:L431 | R:R:L88 | 4.15 | 0 | No | Yes | 8 | 9 | 2 | 1 | | R:R:L88 | R:R:Q432 | 2.66 | 0 | Yes | Yes | 9 | 7 | 1 | 2 | | R:R:L88 | W:W:?3 | 2.54 | 0 | Yes | Yes | 9 | 0 | 1 | 0 | | R:R:P89 | R:R:Y435 | 8.34 | 0 | No | Yes | 8 | 3 | 1 | 2 | | R:R:P89 | W:W:?3 | 9.05 | 0 | No | Yes | 8 | 0 | 1 | 0 | | R:R:Q432 | R:R:Y435 | 3.38 | 47 | Yes | Yes | 7 | 3 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 4.29 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 13.00 | | Average Links Mediated by Hubs In Shell | 11.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9AXF | C | Ion | Calcium-sensing | CaS | Homo Sapiens | Ca | Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 | chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 | 3.5 | 2024-04-17 | 10.1038/s41586-024-07331-1 |
|
A 2D representation of the interactions of CA in 9AXF
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:L37 | R:R:T100 | 4.42 | 1 | Yes | Yes | 6 | 7 | 2 | 1 | | R:R:G143 | R:R:L37 | 1.71 | 1 | No | Yes | 9 | 6 | 2 | 2 | | R:R:A144 | R:R:L37 | 1.58 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | | R:R:L37 | R:R:V153 | 2.98 | 1 | Yes | Yes | 6 | 6 | 2 | 2 | | R:R:N64 | R:R:P39 | 1.63 | 0 | Yes | Yes | 4 | 6 | 2 | 1 | | R:R:P39 | R:R:W70 | 4.05 | 1 | Yes | Yes | 6 | 5 | 1 | 2 | | R:R:P39 | R:R:T100 | 1.75 | 1 | Yes | Yes | 6 | 7 | 1 | 1 | | R:R:N102 | R:R:P39 | 4.89 | 1 | No | Yes | 3 | 6 | 1 | 1 | | R:R:P39 | R:R:T145 | 6.99 | 1 | Yes | Yes | 6 | 5 | 1 | 1 | | I:I:?2 | R:R:P39 | 9.05 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | | R:R:T145 | R:R:W70 | 3.64 | 1 | Yes | Yes | 5 | 5 | 1 | 2 | | R:R:W70 | R:R:Y167 | 1.93 | 1 | Yes | Yes | 5 | 8 | 2 | 2 | | R:R:W70 | W:W:?1 | 3.19 | 1 | Yes | Yes | 5 | 0 | 2 | 2 | | R:R:A107 | R:R:T100 | 3.36 | 1 | No | Yes | 7 | 7 | 2 | 1 | | I:I:?2 | R:R:T100 | 8.12 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:N102 | R:R:P274 | 1.63 | 1 | No | Yes | 3 | 3 | 1 | 2 | | I:I:?2 | R:R:N102 | 2.52 | 1 | Yes | No | 0 | 3 | 0 | 1 | | R:R:V104 | R:R:V149 | 1.6 | 1 | Yes | Yes | 4 | 4 | 2 | 1 | | R:R:A107 | R:R:V149 | 1.7 | 1 | No | Yes | 7 | 4 | 2 | 1 | | R:R:A107 | R:R:V153 | 1.7 | 1 | No | Yes | 7 | 6 | 2 | 2 | | R:R:A144 | R:R:G143 | 1.95 | 1 | Yes | No | 6 | 9 | 1 | 2 | | R:R:G143 | R:R:Y167 | 5.79 | 1 | No | Yes | 9 | 8 | 2 | 2 | | R:R:A144 | R:R:V149 | 1.7 | 1 | Yes | Yes | 6 | 4 | 1 | 1 | | R:R:A144 | R:R:S150 | 1.71 | 1 | Yes | Yes | 6 | 8 | 1 | 2 | | I:I:?2 | R:R:A144 | 2.89 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | | R:R:G146 | R:R:T145 | 1.82 | 1 | Yes | Yes | 5 | 5 | 2 | 1 | | R:R:T145 | R:R:Y167 | 6.24 | 1 | Yes | Yes | 5 | 8 | 1 | 2 | | R:R:A168 | R:R:T145 | 3.36 | 1 | Yes | Yes | 5 | 5 | 2 | 1 | | R:R:T145 | W:W:?1 | 5.17 | 1 | Yes | Yes | 5 | 0 | 1 | 2 | | I:I:?2 | R:R:T145 | 5.41 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | R:R:G146 | R:R:V149 | 1.84 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | | R:R:G146 | W:W:?1 | 2.4 | 1 | Yes | Yes | 5 | 0 | 2 | 2 | | R:R:V149 | R:R:V153 | 1.6 | 1 | Yes | Yes | 4 | 6 | 1 | 2 | | I:I:?2 | R:R:V149 | 2.74 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:A168 | R:R:Y167 | 2.67 | 1 | Yes | Yes | 5 | 8 | 2 | 2 | | R:R:A168 | W:W:?1 | 3.31 | 1 | Yes | Yes | 5 | 0 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 6.00 | | Average Number Of Links With An Hub | 5.00 | | Average Interaction Strength | 5.12 | | Average Nodes In Shell | 20.00 | | Average Hubs In Shell | 17.00 | | Average Links In Shell | 36.00 | | Average Links Mediated by Hubs In Shell | 36.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 9AXF
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:N64 | R:R:R66 | 3.62 | 0 | Yes | Yes | 4 | 5 | 2 | 1 | | R:R:R66 | R:R:R69 | 4.26 | 1 | Yes | Yes | 5 | 8 | 1 | 2 | | R:R:R66 | R:R:W70 | 12 | 1 | Yes | Yes | 5 | 5 | 1 | 2 | | R:R:R66 | W:W:?1 | 5.96 | 1 | Yes | Yes | 5 | 0 | 1 | 2 | | R:R:R66 | W:W:?2 | 13.97 | 1 | Yes | Yes | 5 | 0 | 1 | 2 | | L:L:?1 | R:R:R66 | 4.46 | 0 | No | Yes | 0 | 5 | 0 | 1 | | R:R:R69 | W:W:?2 | 13.97 | 1 | Yes | Yes | 8 | 0 | 2 | 2 | | R:R:W70 | W:W:?1 | 3.19 | 1 | Yes | Yes | 5 | 0 | 2 | 2 | | R:R:W70 | W:W:?2 | 7.86 | 1 | Yes | Yes | 5 | 0 | 2 | 2 | | R:R:G273 | R:R:S302 | 3.71 | 1 | Yes | Yes | 4 | 5 | 2 | 1 | | R:R:G273 | R:R:L304 | 1.71 | 1 | Yes | Yes | 4 | 2 | 2 | 2 | | R:R:G273 | R:R:I305 | 3.53 | 1 | Yes | Yes | 4 | 4 | 2 | 2 | | R:R:L304 | R:R:S302 | 4.5 | 1 | Yes | Yes | 2 | 5 | 2 | 1 | | R:R:I305 | R:R:S302 | 3.1 | 1 | Yes | Yes | 4 | 5 | 2 | 1 | | L:L:?1 | R:R:S302 | 5.51 | 0 | No | Yes | 0 | 5 | 0 | 1 | | R:R:L304 | R:R:S303 | 3 | 1 | Yes | No | 2 | 3 | 2 | 1 | | L:L:?1 | R:R:S303 | 2.76 | 0 | No | No | 0 | 3 | 0 | 1 | | R:R:I305 | R:R:L304 | 2.85 | 1 | Yes | Yes | 4 | 2 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 4.24 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 10.00 | | Average Links In Shell | 18.00 | | Average Links Mediated by Hubs In Shell | 17.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 9AXF
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:E558 | R:R:I555 | 5.47 | 1 | Yes | No | 5 | 5 | 1 | 2 | | R:R:E558 | R:R:G557 | 3.27 | 1 | Yes | No | 5 | 6 | 1 | 1 | | R:R:G557 | S:S:D234 | 5.03 | 1 | No | No | 6 | 5 | 1 | 1 | | I:I:?3 | R:R:G557 | 3.14 | 1 | No | No | 0 | 6 | 0 | 1 | | R:R:E558 | R:R:P559 | 1.57 | 1 | Yes | Yes | 5 | 6 | 1 | 2 | | R:R:C562 | R:R:E558 | 1.52 | 1 | Yes | Yes | 9 | 5 | 2 | 1 | | I:I:?3 | R:R:E558 | 7.3 | 1 | No | Yes | 0 | 5 | 0 | 1 | | R:R:C562 | R:R:P559 | 3.77 | 1 | Yes | Yes | 9 | 6 | 2 | 2 | | I:I:?3 | S:S:D234 | 2.49 | 1 | No | No | 0 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 4.31 | | Average Nodes In Shell | 7.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 9.00 | | Average Links Mediated by Hubs In Shell | 6.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 9AXF
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | |
| Statistics | Value |
|---|
| Average Number Of Links | 0.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 0.00 | | Average Nodes In Shell | 0.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 0.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 9AXF
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:L37 | S:S:T100 | 4.42 | 1 | Yes | Yes | 6 | 7 | 2 | 1 | | S:S:G143 | S:S:L37 | 1.71 | 1 | No | Yes | 9 | 6 | 2 | 2 | | S:S:A144 | S:S:L37 | 3.15 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | | S:S:L37 | S:S:V153 | 2.98 | 1 | Yes | Yes | 6 | 6 | 2 | 2 | | S:S:N64 | S:S:P39 | 3.26 | 0 | Yes | Yes | 4 | 6 | 2 | 1 | | S:S:P39 | S:S:W70 | 4.05 | 1 | Yes | Yes | 6 | 5 | 1 | 2 | | S:S:P39 | S:S:T100 | 1.75 | 1 | Yes | Yes | 6 | 7 | 1 | 1 | | S:S:N102 | S:S:P39 | 4.89 | 1 | No | Yes | 3 | 6 | 1 | 1 | | S:S:P39 | S:S:T145 | 6.99 | 1 | Yes | Yes | 6 | 5 | 1 | 1 | | I:I:?6 | S:S:P39 | 9.05 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | | S:S:T145 | S:S:W70 | 3.64 | 1 | Yes | Yes | 5 | 5 | 1 | 2 | | S:S:W70 | S:S:Y167 | 1.93 | 1 | Yes | Yes | 5 | 8 | 2 | 2 | | S:S:W70 | X:X:?1 | 3.19 | 1 | Yes | Yes | 5 | 0 | 2 | 2 | | S:S:A107 | S:S:T100 | 3.36 | 1 | No | Yes | 7 | 7 | 2 | 1 | | I:I:?6 | S:S:T100 | 8.12 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | S:S:N102 | S:S:P274 | 1.63 | 1 | No | Yes | 3 | 3 | 1 | 2 | | I:I:?6 | S:S:N102 | 2.52 | 1 | Yes | No | 0 | 3 | 0 | 1 | | S:S:V104 | S:S:V149 | 1.6 | 1 | Yes | Yes | 4 | 4 | 2 | 1 | | S:S:A107 | S:S:V149 | 1.7 | 1 | No | Yes | 7 | 4 | 2 | 1 | | S:S:A107 | S:S:V153 | 1.7 | 1 | No | Yes | 7 | 6 | 2 | 2 | | S:S:A144 | S:S:G143 | 1.95 | 1 | Yes | No | 6 | 9 | 1 | 2 | | S:S:G143 | S:S:Y167 | 4.35 | 1 | No | Yes | 9 | 8 | 2 | 2 | | S:S:A144 | S:S:V149 | 1.7 | 1 | Yes | Yes | 6 | 4 | 1 | 1 | | S:S:A144 | S:S:S150 | 1.71 | 1 | Yes | Yes | 6 | 8 | 1 | 2 | | I:I:?6 | S:S:A144 | 2.89 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | | S:S:G146 | S:S:T145 | 1.82 | 0 | No | Yes | 5 | 5 | 2 | 1 | | S:S:T145 | S:S:Y167 | 7.49 | 1 | Yes | Yes | 5 | 8 | 1 | 2 | | S:S:A168 | S:S:T145 | 3.36 | 1 | Yes | Yes | 5 | 5 | 2 | 1 | | S:S:T145 | X:X:?1 | 5.17 | 1 | Yes | Yes | 5 | 0 | 1 | 2 | | I:I:?6 | S:S:T145 | 5.41 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | S:S:V149 | S:S:V153 | 1.6 | 1 | Yes | Yes | 4 | 6 | 1 | 2 | | I:I:?6 | S:S:V149 | 2.74 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | S:S:A168 | S:S:Y167 | 2.67 | 1 | Yes | Yes | 5 | 8 | 2 | 2 | | S:S:A168 | X:X:?1 | 2.21 | 1 | Yes | Yes | 5 | 0 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 6.00 | | Average Number Of Links With An Hub | 5.00 | | Average Interaction Strength | 5.12 | | Average Nodes In Shell | 20.00 | | Average Hubs In Shell | 16.00 | | Average Links In Shell | 34.00 | | Average Links Mediated by Hubs In Shell | 34.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 9AXF
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:F42 | S:S:R62 | 6.41 | 1 | Yes | No | 3 | 4 | 1 | 2 | | S:S:F42 | S:S:N64 | 19.33 | 1 | Yes | Yes | 3 | 4 | 1 | 2 | | S:S:F42 | S:S:L304 | 13.4 | 1 | Yes | Yes | 3 | 2 | 1 | 1 | | M:M:?1 | S:S:F42 | 6.71 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | | S:S:E277 | S:S:R62 | 6.98 | 1 | Yes | No | 2 | 4 | 2 | 2 | | S:S:L304 | S:S:R62 | 4.86 | 1 | Yes | No | 2 | 4 | 1 | 2 | | S:S:N102 | S:S:P274 | 1.63 | 1 | No | Yes | 3 | 3 | 2 | 1 | | S:S:P274 | S:S:Q245 | 1.58 | 1 | Yes | No | 3 | 4 | 1 | 2 | | S:S:G273 | S:S:S272 | 1.86 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | | S:S:P274 | S:S:S272 | 3.56 | 1 | Yes | Yes | 3 | 5 | 1 | 2 | | S:S:G273 | S:S:P274 | 4.06 | 1 | Yes | Yes | 4 | 3 | 1 | 1 | | S:S:G273 | S:S:S302 | 3.71 | 1 | Yes | Yes | 4 | 5 | 1 | 1 | | S:S:G273 | S:S:I305 | 3.53 | 1 | Yes | Yes | 4 | 4 | 1 | 2 | | M:M:?1 | S:S:G273 | 3.14 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | S:S:L304 | S:S:P274 | 3.28 | 1 | Yes | Yes | 2 | 3 | 1 | 1 | | M:M:?1 | S:S:P274 | 3.02 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | | S:S:E277 | S:S:L304 | 3.98 | 1 | Yes | Yes | 2 | 2 | 2 | 1 | | S:S:L304 | S:S:S302 | 3 | 1 | Yes | Yes | 2 | 5 | 1 | 1 | | S:S:I305 | S:S:S302 | 3.1 | 1 | Yes | Yes | 4 | 5 | 2 | 1 | | M:M:?1 | S:S:S302 | 5.51 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | S:S:L304 | S:S:S303 | 1.5 | 1 | Yes | No | 2 | 3 | 1 | 2 | | M:M:?1 | S:S:L304 | 5.08 | 1 | Yes | Yes | 0 | 2 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 5.00 | | Average Interaction Strength | 4.69 | | Average Nodes In Shell | 14.00 | | Average Hubs In Shell | 10.00 | | Average Links In Shell | 22.00 | | Average Links Mediated by Hubs In Shell | 22.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 9AXF
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D234 | S:S:G557 | 1.68 | 1 | No | No | 5 | 6 | 1 | 1 | | I:I:?7 | R:R:D234 | 2.49 | 1 | No | No | 0 | 5 | 0 | 1 | | S:S:E558 | S:S:I555 | 5.47 | 1 | Yes | No | 5 | 5 | 1 | 2 | | I:I:?7 | S:S:G557 | 3.14 | 1 | No | No | 0 | 6 | 0 | 1 | | S:S:E558 | S:S:P559 | 4.72 | 1 | Yes | Yes | 5 | 6 | 1 | 2 | | S:S:C562 | S:S:E558 | 1.52 | 1 | Yes | Yes | 9 | 5 | 2 | 1 | | I:I:?7 | S:S:E558 | 4.87 | 1 | No | Yes | 0 | 5 | 0 | 1 | | S:S:C562 | S:S:P559 | 3.77 | 1 | Yes | Yes | 9 | 6 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 3.50 | | Average Nodes In Shell | 7.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 8.00 | | Average Links Mediated by Hubs In Shell | 5.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9AYF | C | Ion | Calcium-sensing | CaS | Homo Sapiens | Ca | Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 | Gi1/Beta1/Gamma2 | 3.6 | 2024-04-17 | 10.1038/s41586-024-07331-1 |
|
A 2D representation of the interactions of CA in 9AYF
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:L88 | S:S:P89 | 1.64 | 1 | Yes | Yes | 9 | 8 | 1 | 2 | | S:S:A428 | S:S:L88 | 1.58 | 1 | No | Yes | 9 | 9 | 2 | 1 | | S:S:L431 | S:S:L88 | 5.54 | 0 | No | Yes | 8 | 9 | 2 | 1 | | S:S:L88 | S:S:Q432 | 5.32 | 1 | Yes | Yes | 9 | 7 | 1 | 2 | | I:I:?5 | S:S:L88 | 2.54 | 0 | No | Yes | 0 | 9 | 0 | 1 | | S:S:P89 | S:S:Q432 | 1.58 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 2.54 | | Average Nodes In Shell | 6.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 6.00 | | Average Links Mediated by Hubs In Shell | 6.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 9AYF
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:L37 | S:S:T100 | 4.42 | 1 | Yes | Yes | 6 | 7 | 2 | 1 | | S:S:G67 | S:S:P39 | 2.03 | 1 | No | Yes | 4 | 6 | 2 | 1 | | S:S:P39 | S:S:W70 | 4.05 | 1 | Yes | Yes | 6 | 5 | 1 | 2 | | S:S:P39 | S:S:T100 | 1.75 | 1 | Yes | Yes | 6 | 7 | 1 | 1 | | S:S:N102 | S:S:P39 | 4.89 | 1 | No | Yes | 3 | 6 | 1 | 1 | | S:S:P39 | S:S:T145 | 5.25 | 1 | Yes | Yes | 6 | 5 | 1 | 1 | | I:I:?6 | S:S:P39 | 9.05 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | | S:S:G67 | S:S:W70 | 5.63 | 1 | No | Yes | 4 | 5 | 2 | 2 | | S:S:T145 | S:S:W70 | 3.64 | 1 | Yes | Yes | 5 | 5 | 1 | 2 | | S:S:W70 | S:S:Y167 | 4.82 | 1 | Yes | Yes | 5 | 8 | 2 | 2 | | S:S:W70 | X:X:?1 | 2.4 | 1 | Yes | Yes | 5 | 0 | 2 | 2 | | S:S:A107 | S:S:T100 | 3.36 | 1 | No | Yes | 7 | 7 | 2 | 1 | | I:I:?6 | S:S:T100 | 8.12 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | I:I:?6 | S:S:N102 | 2.52 | 1 | Yes | No | 0 | 3 | 0 | 1 | | S:S:A107 | S:S:V149 | 1.7 | 1 | No | Yes | 7 | 4 | 2 | 2 | | S:S:A144 | S:S:G143 | 1.95 | 0 | Yes | No | 6 | 9 | 1 | 2 | | S:S:G143 | S:S:Y167 | 4.35 | 0 | No | Yes | 9 | 8 | 2 | 2 | | S:S:A144 | S:S:V149 | 3.39 | 0 | Yes | Yes | 6 | 4 | 1 | 2 | | S:S:A144 | S:S:S150 | 1.71 | 0 | Yes | Yes | 6 | 8 | 1 | 2 | | I:I:?6 | S:S:A144 | 2.89 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | | S:S:G146 | S:S:T145 | 1.82 | 0 | No | Yes | 5 | 5 | 2 | 1 | | S:S:T145 | S:S:Y167 | 4.99 | 1 | Yes | Yes | 5 | 8 | 1 | 2 | | S:S:A168 | S:S:T145 | 3.36 | 1 | No | Yes | 5 | 5 | 2 | 1 | | S:S:T145 | X:X:?1 | 3.1 | 1 | Yes | Yes | 5 | 0 | 1 | 2 | | I:I:?6 | S:S:T145 | 5.41 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | S:S:A168 | S:S:Y167 | 2.67 | 1 | No | Yes | 5 | 8 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 4.00 | | Average Interaction Strength | 5.60 | | Average Nodes In Shell | 17.00 | | Average Hubs In Shell | 11.00 | | Average Links In Shell | 26.00 | | Average Links Mediated by Hubs In Shell | 26.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 9AYF
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:F42 | S:S:R62 | 6.41 | 1 | Yes | Yes | 3 | 4 | 1 | 2 | | S:S:F42 | S:S:N64 | 14.5 | 1 | Yes | No | 3 | 4 | 1 | 2 | | S:S:F42 | S:S:L304 | 9.74 | 1 | Yes | Yes | 3 | 2 | 1 | 2 | | M:M:?7 | S:S:F42 | 2.24 | 0 | Yes | Yes | 0 | 3 | 0 | 1 | | S:S:L304 | S:S:R62 | 3.64 | 1 | Yes | Yes | 2 | 4 | 2 | 2 | | S:S:N64 | S:S:R66 | 3.62 | 0 | No | Yes | 4 | 5 | 2 | 1 | | S:S:R66 | S:S:R69 | 5.33 | 1 | Yes | Yes | 5 | 8 | 1 | 2 | | S:S:R66 | S:S:W70 | 10 | 1 | Yes | Yes | 5 | 5 | 1 | 2 | | S:S:R66 | X:X:?1 | 5.11 | 1 | Yes | Yes | 5 | 0 | 1 | 2 | | S:S:R66 | X:X:?2 | 22.36 | 1 | Yes | Yes | 5 | 0 | 1 | 2 | | M:M:?7 | S:S:R66 | 4.46 | 0 | Yes | Yes | 0 | 5 | 0 | 1 | | S:S:R69 | X:X:?2 | 13.97 | 1 | Yes | Yes | 8 | 0 | 2 | 2 | | S:S:W70 | X:X:?1 | 2.4 | 1 | Yes | Yes | 5 | 0 | 2 | 2 | | S:S:W70 | X:X:?2 | 7.86 | 1 | Yes | Yes | 5 | 0 | 2 | 2 | | S:S:G273 | S:S:S302 | 3.71 | 1 | Yes | Yes | 4 | 5 | 2 | 1 | | S:S:G273 | S:S:I305 | 3.53 | 1 | Yes | Yes | 4 | 4 | 2 | 2 | | S:S:L304 | S:S:S302 | 3 | 1 | Yes | Yes | 2 | 5 | 2 | 1 | | S:S:I305 | S:S:S302 | 3.1 | 1 | Yes | Yes | 4 | 5 | 2 | 1 | | M:M:?7 | S:S:S302 | 5.51 | 0 | Yes | Yes | 0 | 5 | 0 | 1 | | S:S:L304 | S:S:S303 | 1.5 | 1 | Yes | No | 2 | 3 | 2 | 1 | | M:M:?7 | S:S:S303 | 2.76 | 0 | Yes | No | 0 | 3 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 3.74 | | Average Nodes In Shell | 14.00 | | Average Hubs In Shell | 12.00 | | Average Links In Shell | 21.00 | | Average Links Mediated by Hubs In Shell | 21.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 9AYF
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D234 | S:S:G557 | 1.68 | 0 | No | No | 5 | 6 | 1 | 2 | | I:I:?8 | R:R:D234 | 7.48 | 0 | No | No | 0 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 7.48 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 2.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 9AYF
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:L88 | R:R:L91 | 5.54 | 0 | Yes | No | 9 | 6 | 1 | 2 | | R:R:L88 | R:R:L93 | 4.15 | 0 | Yes | Yes | 9 | 9 | 1 | 2 | | R:R:L431 | R:R:L88 | 4.15 | 0 | No | Yes | 8 | 9 | 2 | 1 | | R:R:L88 | R:R:Q432 | 6.65 | 0 | Yes | Yes | 9 | 7 | 1 | 2 | | I:I:?1 | R:R:L88 | 2.54 | 0 | No | Yes | 0 | 9 | 0 | 1 | | R:R:P89 | R:R:Q432 | 1.58 | 1 | No | Yes | 8 | 7 | 1 | 2 | | R:R:P89 | R:R:Y435 | 6.95 | 1 | No | Yes | 8 | 3 | 1 | 2 | | I:I:?1 | R:R:P89 | 3.02 | 0 | No | No | 0 | 8 | 0 | 1 | | R:R:Q432 | R:R:Y435 | 9.02 | 1 | Yes | Yes | 7 | 3 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 2.78 | | Average Nodes In Shell | 8.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 9.00 | | Average Links Mediated by Hubs In Shell | 8.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 9AYF
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:L37 | R:R:T100 | 4.42 | 1 | Yes | Yes | 6 | 7 | 2 | 1 | | R:R:G143 | R:R:L37 | 1.71 | 1 | Yes | Yes | 9 | 6 | 2 | 2 | | R:R:A144 | R:R:L37 | 1.58 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | | R:R:N64 | R:R:P39 | 3.26 | 0 | Yes | Yes | 4 | 6 | 2 | 1 | | R:R:P39 | R:R:W70 | 4.05 | 1 | Yes | Yes | 6 | 5 | 1 | 2 | | R:R:P39 | R:R:T100 | 1.75 | 1 | Yes | Yes | 6 | 7 | 1 | 1 | | R:R:N102 | R:R:P39 | 6.52 | 1 | No | Yes | 3 | 6 | 1 | 1 | | R:R:P39 | R:R:T145 | 6.99 | 1 | Yes | Yes | 6 | 5 | 1 | 1 | | I:I:?2 | R:R:P39 | 9.05 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | | R:R:T145 | R:R:W70 | 3.64 | 1 | Yes | Yes | 5 | 5 | 1 | 2 | | R:R:W70 | R:R:Y167 | 4.82 | 1 | Yes | Yes | 5 | 8 | 2 | 2 | | R:R:W70 | W:W:?1 | 2.4 | 1 | Yes | Yes | 5 | 0 | 2 | 2 | | R:R:A107 | R:R:T100 | 3.36 | 1 | No | Yes | 7 | 7 | 2 | 1 | | I:I:?2 | R:R:T100 | 8.12 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | I:I:?2 | R:R:N102 | 2.52 | 1 | Yes | No | 0 | 3 | 0 | 1 | | R:R:A107 | R:R:V149 | 1.7 | 1 | No | Yes | 7 | 4 | 2 | 2 | | R:R:A144 | R:R:G143 | 1.95 | 1 | Yes | Yes | 6 | 9 | 1 | 2 | | R:R:G143 | R:R:Y167 | 5.79 | 1 | Yes | Yes | 9 | 8 | 2 | 2 | | R:R:A144 | R:R:V149 | 1.7 | 1 | Yes | Yes | 6 | 4 | 1 | 2 | | R:R:A144 | R:R:S150 | 1.71 | 1 | Yes | Yes | 6 | 8 | 1 | 2 | | I:I:?2 | R:R:A144 | 2.89 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | | R:R:G146 | R:R:T145 | 1.82 | 0 | No | Yes | 5 | 5 | 2 | 1 | | R:R:T145 | R:R:Y167 | 4.99 | 1 | Yes | Yes | 5 | 8 | 1 | 2 | | R:R:A168 | R:R:T145 | 3.36 | 1 | Yes | Yes | 5 | 5 | 2 | 1 | | R:R:T145 | W:W:?1 | 5.17 | 1 | Yes | Yes | 5 | 0 | 1 | 2 | | I:I:?2 | R:R:T145 | 5.41 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | R:R:A168 | R:R:Y167 | 2.67 | 1 | Yes | Yes | 5 | 8 | 2 | 2 | | R:R:A168 | W:W:?1 | 2.21 | 1 | Yes | Yes | 5 | 0 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 4.00 | | Average Interaction Strength | 5.60 | | Average Nodes In Shell | 17.00 | | Average Hubs In Shell | 14.00 | | Average Links In Shell | 28.00 | | Average Links Mediated by Hubs In Shell | 28.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 9AYF
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:N64 | R:R:R66 | 3.62 | 0 | Yes | Yes | 4 | 5 | 2 | 1 | | R:R:R66 | R:R:R69 | 4.26 | 1 | Yes | Yes | 5 | 8 | 1 | 2 | | R:R:R66 | R:R:W70 | 13 | 1 | Yes | Yes | 5 | 5 | 1 | 2 | | R:R:R66 | W:W:?1 | 5.11 | 1 | Yes | Yes | 5 | 0 | 1 | 1 | | R:R:R66 | W:W:?2 | 20.96 | 1 | Yes | Yes | 5 | 0 | 1 | 2 | | L:L:?3 | R:R:R66 | 2.23 | 1 | No | Yes | 0 | 5 | 0 | 1 | | R:R:R69 | W:W:?2 | 11.18 | 1 | Yes | Yes | 8 | 0 | 2 | 2 | | R:R:T145 | R:R:W70 | 3.64 | 1 | Yes | Yes | 5 | 5 | 2 | 2 | | R:R:W70 | W:W:?1 | 2.4 | 1 | Yes | Yes | 5 | 0 | 2 | 1 | | R:R:W70 | W:W:?2 | 7.86 | 1 | Yes | Yes | 5 | 0 | 2 | 2 | | R:R:A168 | R:R:T145 | 3.36 | 1 | Yes | Yes | 5 | 5 | 2 | 2 | | R:R:T145 | W:W:?1 | 5.17 | 1 | Yes | Yes | 5 | 0 | 2 | 1 | | R:R:S147 | W:W:?1 | 5.26 | 0 | No | Yes | 8 | 0 | 2 | 1 | | R:R:A168 | W:W:?1 | 2.21 | 1 | Yes | Yes | 5 | 0 | 2 | 1 | | R:R:S170 | R:R:Y218 | 2.54 | 1 | Yes | Yes | 7 | 7 | 2 | 2 | | R:R:S170 | W:W:?1 | 7.37 | 1 | Yes | Yes | 7 | 0 | 2 | 1 | | R:R:A298 | R:R:Y218 | 4 | 1 | Yes | Yes | 6 | 7 | 2 | 2 | | R:R:Y218 | W:W:?1 | 18.08 | 1 | Yes | Yes | 7 | 0 | 2 | 1 | | R:R:G273 | R:R:S302 | 3.71 | 1 | Yes | Yes | 4 | 5 | 2 | 1 | | R:R:G273 | R:R:I305 | 3.53 | 1 | Yes | Yes | 4 | 4 | 2 | 2 | | R:R:E297 | W:W:?1 | 5.57 | 0 | No | Yes | 8 | 0 | 2 | 1 | | R:R:A298 | W:W:?1 | 7.73 | 1 | Yes | Yes | 6 | 0 | 2 | 1 | | R:R:L304 | R:R:S302 | 3 | 0 | Yes | Yes | 2 | 5 | 2 | 1 | | R:R:I305 | R:R:S302 | 3.1 | 1 | Yes | Yes | 4 | 5 | 2 | 1 | | L:L:?3 | R:R:S302 | 5.51 | 1 | No | Yes | 0 | 5 | 0 | 1 | | L:L:?3 | W:W:?1 | 1.78 | 1 | No | Yes | 0 | 0 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 3.17 | | Average Nodes In Shell | 18.00 | | Average Hubs In Shell | 15.00 | | Average Links In Shell | 26.00 | | Average Links Mediated by Hubs In Shell | 26.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of CA in 9AYF
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:G557 | S:S:D234 | 1.68 | 1 | No | No | 6 | 5 | 1 | 1 | | I:I:?4 | S:S:D234 | 4.98 | 1 | No | No | 0 | 5 | 0 | 1 | | R:R:E558 | R:R:I555 | 4.1 | 1 | Yes | No | 5 | 5 | 1 | 2 | | I:I:?4 | R:R:G557 | 3.14 | 1 | No | No | 0 | 6 | 0 | 1 | | R:R:E558 | R:R:P559 | 7.86 | 1 | Yes | Yes | 5 | 6 | 1 | 2 | | R:R:C562 | R:R:E558 | 1.52 | 1 | Yes | Yes | 9 | 5 | 2 | 1 | | I:I:?4 | R:R:E558 | 2.43 | 1 | No | Yes | 0 | 5 | 0 | 1 | | R:R:C562 | R:R:P559 | 1.88 | 1 | Yes | Yes | 9 | 6 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 3.52 | | Average Nodes In Shell | 7.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 8.00 | | Average Links Mediated by Hubs In Shell | 5.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
