psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Y20	S:S:L125	5.86	No	Yes	0	2	4
2	R:R:G21	R:R:P22	4.06	No	No	0	3	5
3	R:R:G21	R:R:S113	3.71	No	No	0	3	4
4	R:R:F98	R:R:P22	8.67	Yes	No	0	4	5
5	R:R:D23	R:R:R25	8.34	No	No	0	1	4
6	R:R:Q27	R:R:R25	3.5	No	No	0	4	4
7	R:R:F98	R:R:R25	5.34	Yes	No	0	4	4
8	R:R:A26	R:R:I97	3.25	No	Yes	0	6	8
9	R:R:K29	R:R:Q27	5.42	No	No	0	3	4
10	R:R:Q27	R:R:R96	3.5	No	Yes	0	4	4
11	R:R:K28	R:R:N82	4.2	No	No	0	5	9
12	R:R:K28	R:R:Y95	13.14	No	Yes	0	5	8
13	R:R:H344	R:R:K28	6.55	No	No	0	3	5
14	R:R:K29	R:R:P136	3.35	No	No	0	3	4
15	R:R:D31	R:R:L91	6.79	No	No	0	8	6
16	R:R:I139	R:R:I32	4.42	No	No	0	5	6
17	R:R:I32	R:R:L431	4.28	No	No	0	6	8
18	R:R:I32	R:R:V455	3.07	No	No	0	6	4
19	R:R:I33	R:R:R96	5.01	No	Yes	0	5	4
20	R:R:I33	R:R:T138	3.04	No	No	0	5	6
21	R:R:I427	R:R:L34	4.28	No	No	0	5	7
22	R:R:F114	R:R:G35	3.01	Yes	No	0	5	8
23	R:R:L37	R:R:T100	5.9	No	No	0	6	7
24	R:R:F114	R:R:L37	3.65	Yes	No	0	5	6
25	R:R:L37	R:R:V153	2.98	No	No	0	6	6
26	R:R:F38	R:R:P39	4.33	Yes	Yes	1	7	6
27	R:R:F38	R:R:L71	6.09	Yes	No	1	7	4
28	R:R:F38	R:R:M74	7.46	Yes	No	1	7	8
29	R:R:F38	R:R:I97	3.77	Yes	Yes	1	7	8
30	R:R:F38	R:R:Y167	10.32	Yes	Yes	1	7	8
31	R:R:F38	R:R:V420	3.93	Yes	No	1	7	7
32	R:R:N64	R:R:P39	3.26	Yes	Yes	0	4	6
33	R:R:P39	R:R:W70	5.4	Yes	Yes	1	6	5
34	R:R:P39	R:R:T145	8.74	Yes	Yes	1	6	5
35	R:R:I40	R:R:Y63	3.63	Yes	Yes	1	5	5
36	R:R:I40	R:R:L71	4.28	Yes	No	1	5	4
37	R:R:D99	R:R:I40	9.8	Yes	Yes	1	9	5
38	R:R:F347	R:R:I40	3.77	Yes	Yes	1	5	5
39	R:R:C60	R:R:H41	8.85	No	Yes	1	7	7
40	R:R:H41	R:R:Y63	5.44	Yes	Yes	1	7	5
41	R:R:D99	R:R:H41	3.78	Yes	Yes	1	9	7
42	R:R:C101	R:R:H41	5.9	Yes	Yes	1	8	7
43	R:R:E350	R:R:H41	4.92	No	Yes	1	5	7
44	R:R:F42	R:R:R62	8.55	Yes	No	0	3	4
45	R:R:F42	R:R:N64	13.29	Yes	Yes	0	3	4
46	R:R:F42	R:R:P274	7.22	Yes	Yes	32	3	3
47	R:R:F42	R:R:L304	10.96	Yes	No	32	3	2
48	L:L:?1102	R:R:F42	4.47	No	Yes	0	0	3
49	R:R:V44	R:R:V58	6.41	No	No	0	2	1
50	R:R:T103	R:R:V44	6.35	No	No	0	4	2
51	R:R:K47	R:R:Q49	4.07	No	No	0	2	1
52	R:R:K47	R:R:V58	3.04	No	No	0	2	1
53	R:R:Q49	S:S:Y161	6.76	No	Yes	0	1	4
54	R:R:D50	R:R:K52	4.15	No	No	0	3	3
55	R:R:L51	R:R:P55	4.93	Yes	No	17	6	6
56	R:R:L51	S:S:Y161	3.52	Yes	Yes	17	6	4
57	R:R:L51	S:S:W458	3.42	Yes	Yes	17	6	4
58	R:R:L51	S:S:K462	4.23	Yes	No	0	6	4
59	R:R:L51	S:S:R465	7.29	Yes	No	0	6	5
60	R:R:R54	S:S:E456	3.49	No	No	17	2	5
61	R:R:R54	S:S:W458	9	No	Yes	17	2	4
62	R:R:P55	S:S:Y161	11.13	No	Yes	17	6	4
63	R:R:P55	S:S:W458	12.16	No	Yes	17	6	4
64	R:R:K106	R:R:S57	3.06	Yes	No	0	4	1
65	R:R:C101	R:R:C60	7.28	Yes	No	1	8	7
66	R:R:C60	R:R:K106	3.23	No	Yes	0	7	4
67	R:R:F65	R:R:Y63	10.32	Yes	Yes	1	2	5
68	R:R:F68	R:R:Y63	3.09	Yes	Yes	1	7	5
69	R:R:E350	R:R:Y63	4.49	No	Yes	1	5	5
70	R:R:F351	R:R:Y63	5.16	Yes	Yes	1	6	5
71	R:R:E354	R:R:Y63	4.49	No	Yes	0	4	5
72	R:R:N64	R:R:R66	3.62	Yes	Yes	0	4	5
73	R:R:G67	R:R:N64	5.09	No	Yes	0	4	4
74	R:R:F351	R:R:F65	4.29	Yes	Yes	1	6	2
75	R:R:F65	R:R:T355	5.19	Yes	Yes	1	2	4
76	R:R:F65	R:R:T406	9.08	Yes	No	1	2	4
77	R:R:F65	R:R:Y408	3.09	Yes	Yes	1	2	3
78	R:R:R66	R:R:R69	3.2	Yes	No	0	5	8
79	R:R:R66	R:R:W70	11	Yes	Yes	0	5	5
80	R:R:R66	W:W:W1101	3	Yes	Yes	0	5	0
81	R:R:G67	R:R:W70	5.63	No	Yes	0	4	5
82	R:R:F68	R:R:Q72	10.54	Yes	No	0	7	7
83	R:R:F351	R:R:F68	9.65	Yes	Yes	1	6	7
84	R:R:F68	R:R:Y408	6.19	Yes	Yes	1	7	3
85	R:R:F330	R:R:R69	3.21	Yes	No	0	8	8
86	R:R:R69	R:R:Y411	11.32	No	Yes	0	8	5
87	R:R:T145	R:R:W70	3.64	Yes	Yes	1	5	5
88	R:R:W70	R:R:Y167	4.82	Yes	Yes	1	5	8
89	R:R:I416	R:R:W70	11.74	No	Yes	0	4	5
90	R:R:F347	R:R:L71	3.65	Yes	No	1	5	4
91	R:R:F333	R:R:Q72	4.68	No	No	0	7	7
92	R:R:N345	R:R:Q72	3.96	No	No	0	8	7
93	R:R:A73	R:R:F330	4.16	No	Yes	13	7	8
94	R:R:A73	R:R:S417	3.42	No	No	13	7	6
95	R:R:I97	R:R:M74	8.75	Yes	No	1	8	8
96	R:R:M74	R:R:V142	4.56	No	No	0	8	7
97	R:R:I75	R:R:Y95	13.3	No	Yes	0	4	8
98	R:R:E80	R:R:F76	4.66	No	Yes	13	8	7
99	R:R:F76	R:R:I327	3.77	Yes	Yes	13	7	6
100	R:R:F330	R:R:F76	7.5	Yes	Yes	13	8	7
101	R:R:F333	R:R:F76	13.93	No	Yes	0	7	7
102	R:R:F76	R:R:Y421	4.13	Yes	Yes	13	7	8
103	R:R:A77	R:R:Y421	5.34	No	Yes	0	8	8
104	R:R:I78	R:R:Y95	7.25	No	Yes	0	6	8
105	R:R:I78	R:R:V424	3.07	No	No	0	6	8
106	R:R:E80	R:R:Y421	6.73	No	Yes	13	8	8
107	R:R:E80	R:R:Y425	5.61	No	No	13	8	8
108	R:R:I81	R:R:L93	5.71	No	No	0	9	9
109	R:R:I81	R:R:Y425	4.84	No	No	0	9	8
110	R:R:A428	R:R:I81	3.25	No	No	0	9	9
111	R:R:N82	R:R:T92	10.24	No	No	0	9	7
112	R:R:H429	R:R:L87	3.86	No	No	0	6	6
113	R:R:L87	R:R:Q432	7.99	No	No	0	6	7
114	R:R:L431	R:R:L88	4.15	No	No	0	8	9
115	R:R:P89	R:R:Y435	9.74	No	No	0	8	3
116	R:R:I452	R:R:L91	4.28	No	No	0	3	6
117	R:R:I97	R:R:Y95	8.46	Yes	Yes	0	8	8
118	R:R:F98	R:R:R96	5.34	Yes	Yes	0	4	4
119	R:R:I135	R:R:R96	3.76	No	Yes	0	4	4
120	R:R:A110	R:R:F98	5.55	No	Yes	0	5	4
121	R:R:F114	R:R:F98	7.5	Yes	Yes	0	5	4
122	R:R:C101	R:R:D99	4.67	Yes	Yes	1	8	9
123	R:R:D99	R:R:F347	3.58	Yes	Yes	1	9	5
124	R:R:A107	R:R:T100	3.36	No	No	0	7	7
125	R:R:K106	R:R:T103	3	Yes	No	0	4	4
126	R:R:L108	R:R:V104	2.98	No	Yes	0	4	4
127	R:R:A152	R:R:V104	5.09	No	Yes	0	5	4
128	R:R:V104	S:S:N155	7.39	Yes	No	9	4	5
129	R:R:V104	S:S:Q179	4.3	Yes	No	9	4	5
130	R:R:K106	R:R:S105	3.06	Yes	No	0	4	4
131	R:R:S105	S:S:L159	3	No	No	0	4	5
132	R:R:E109	S:S:S122	5.75	No	No	0	5	3
133	R:R:F114	R:R:T111	3.89	Yes	No	0	5	7
134	R:R:T111	R:R:V153	7.93	No	No	31	7	6
135	R:R:L157	R:R:T111	4.42	Yes	No	31	7	7
136	R:R:S113	S:S:L123	3	No	No	0	4	5
137	R:R:F114	R:R:T138	6.49	Yes	No	0	5	6
138	R:R:F114	R:R:V141	6.55	Yes	No	0	5	7
139	R:R:F160	R:R:V115	13.11	Yes	No	0	7	5
140	R:R:I162	R:R:V115	3.07	Yes	No	0	6	5
141	R:R:F128	R:R:Q117	7.03	No	No	0	3	6
142	R:R:Q117	R:R:S137	5.78	No	No	0	6	4
143	R:R:F160	R:R:N118	4.83	Yes	No	0	7	4
144	R:R:I162	R:R:N118	5.66	Yes	No	0	6	4
145	R:R:K119	S:S:K119	11.49	No	No	0	3	3
146	R:R:D126	R:R:I120	4.2	No	No	0	3	3
147	R:R:D121	R:R:S122	5.89	No	No	0	3	3
148	R:R:D121	R:R:F160	7.17	No	Yes	0	3	7
149	R:R:S122	S:S:E109	5.75	No	No	0	3	5
150	R:R:L123	S:S:S113	3	No	No	0	5	4
151	R:R:L125	S:S:Y20	5.86	Yes	No	0	4	2
152	R:R:L125	S:S:N130	16.48	Yes	No	0	4	2
153	R:R:L125	S:S:C131	4.76	Yes	No	0	4	3
154	R:R:L125	S:S:I135	4.28	Yes	No	0	4	4
155	R:R:D126	R:R:F128	10.75	No	No	0	3	3
156	R:R:E127	S:S:C129	15.19	No	No	0	4	8
157	R:R:E127	S:S:N130	5.26	No	No	0	4	2
158	R:R:F128	R:R:H134	37.33	No	No	0	3	4
159	R:R:C129	S:S:E127	15.19	No	No	0	8	4
160	R:R:C129	S:S:C129	7.28	No	No	0	8	8
161	R:R:N130	S:S:L125	16.48	No	Yes	0	2	4
162	R:R:N130	S:S:E127	5.26	No	No	0	2	4
163	R:R:C131	S:S:L125	4.76	No	Yes	0	3	4
164	R:R:E133	R:R:S132	8.62	No	No	0	5	4
165	R:R:E133	R:R:P136	4.72	No	No	0	5	4
166	R:R:I135	S:S:L125	4.28	No	Yes	0	4	4
167	R:R:I139	R:R:V460	4.61	No	No	0	5	7
168	R:R:A140	R:R:P163	3.74	No	Yes	0	6	8
169	R:R:A140	R:R:I427	4.87	No	No	0	6	5
170	R:R:L157	R:R:V141	4.47	Yes	No	0	7	7
171	R:R:G143	R:R:Y167	5.79	No	Yes	0	9	8
172	R:R:A144	R:R:V149	3.39	No	No	0	6	4
173	R:R:A144	R:R:S150	3.42	No	No	0	6	8
174	R:R:G146	R:R:T145	3.64	No	Yes	0	5	5
175	R:R:T145	R:R:Y167	4.99	Yes	Yes	1	5	8
176	R:R:A168	R:R:T145	3.36	No	Yes	1	5	5
177	R:R:T145	W:W:W1101	3.64	Yes	Yes	1	5	0
178	R:R:G146	R:R:V149	3.68	No	No	0	5	4
179	R:R:S147	R:R:S169	3.26	No	Yes	10	8	8
180	R:R:S147	R:R:S171	6.52	No	No	10	8	7
181	R:R:L174	R:R:S147	4.5	Yes	No	10	7	8
182	R:R:D217	R:R:G148	5.03	No	No	0	6	4
183	R:R:S150	R:R:S169	6.52	No	Yes	10	8	8
184	R:R:L174	R:R:S150	3	Yes	No	10	7	8
185	R:R:L174	R:R:T151	4.42	Yes	No	10	7	5
186	R:R:F180	R:R:T151	6.49	Yes	No	10	5	5
187	R:R:L157	R:R:V153	2.98	Yes	No	31	7	6
188	R:R:A154	R:R:Q164	3.03	No	No	0	7	8
189	R:R:A154	R:R:F180	4.16	No	Yes	0	7	5
190	R:R:N155	R:R:Q179	3.96	No	No	10	5	5
191	R:R:F180	R:R:N155	3.62	Yes	No	10	5	5
192	R:R:N155	S:S:V104	7.39	No	Yes	10	5	4
193	R:R:I162	R:R:L157	5.71	Yes	Yes	0	6	7
194	R:R:F160	R:R:L159	6.09	Yes	No	0	7	5
195	R:R:L159	S:S:S105	3	No	No	0	5	4
196	R:R:K181	R:R:Y161	9.55	No	Yes	0	7	4
197	R:R:Y161	S:S:Q49	6.76	Yes	No	0	4	1
198	R:R:Y161	S:S:L51	3.52	Yes	Yes	18	4	6
199	R:R:Y161	S:S:P55	11.13	Yes	No	18	4	6
200	R:R:I162	R:R:P163	3.39	Yes	Yes	0	6	8
201	R:R:A457	R:R:I162	3.25	No	Yes	0	4	6
202	R:R:L461	R:R:P163	6.57	No	Yes	0	7	8
203	R:R:L464	R:R:P163	3.28	No	Yes	0	7	8
204	R:R:F183	R:R:Q164	11.71	Yes	No	0	8	8
205	R:R:A423	R:R:V165	3.39	No	No	0	9	6
206	R:R:I427	R:R:V165	4.61	No	No	0	5	6
207	R:R:S166	R:R:S169	4.89	No	Yes	10	9	8
208	R:R:F183	R:R:S166	3.96	Yes	No	10	8	9
209	R:R:V420	R:R:Y167	7.57	No	Yes	1	7	8
210	R:R:A168	W:W:W1101	3.89	No	Yes	1	5	0
211	R:R:L174	R:R:S169	3	Yes	Yes	10	7	8
212	R:R:F183	R:R:S169	3.96	Yes	Yes	10	8	8
213	R:R:I187	R:R:S170	4.64	No	No	0	6	7
214	R:R:D190	R:R:S170	5.89	Yes	No	0	8	7
215	R:R:L174	R:R:S171	3	Yes	No	10	7	7
216	R:R:L173	R:R:R172	4.86	No	No	0	5	4
217	R:R:N189	R:R:R172	3.62	Yes	No	0	8	4
218	R:R:R172	S:S:D215	9.53	No	No	0	4	6
219	R:R:L173	R:R:P221	9.85	No	No	0	5	3
220	R:R:L173	S:S:R220	8.5	No	No	0	5	6
221	R:R:F180	R:R:L174	7.31	Yes	Yes	10	5	7
222	R:R:F183	R:R:L174	15.83	Yes	Yes	10	8	7
223	R:R:N189	R:R:S175	2.98	Yes	No	0	8	8
224	R:R:C482	R:R:S175	5.16	No	No	0	7	8
225	R:R:N178	S:S:Y246	12.79	No	No	0	3	3
226	R:R:F180	R:R:Q179	8.2	Yes	No	10	5	5
227	R:R:Q179	S:S:V104	4.3	No	Yes	10	5	4
228	R:R:L461	R:R:S182	4.5	No	No	0	7	7
229	R:R:F183	R:R:R185	8.55	Yes	No	0	8	9
230	R:R:L184	R:R:L464	5.54	No	No	0	6	7
231	R:R:F479	R:R:L184	6.09	No	No	0	8	6
232	R:R:N189	R:R:R185	6.03	Yes	No	0	8	9
233	R:R:D484	R:R:R185	3.57	No	No	0	8	9
234	R:R:N419	R:R:T186	5.85	No	No	0	7	8
235	R:R:I187	R:R:P188	3.39	No	No	0	6	8
236	R:R:P188	R:R:Y489	4.17	No	Yes	0	8	8
237	R:R:E191	R:R:N189	3.94	No	Yes	0	3	8
238	R:R:D190	R:R:Q193	10.44	Yes	Yes	19	8	9
239	R:R:D190	R:R:Y218	5.75	Yes	Yes	19	8	7
240	R:R:D190	R:R:F270	5.97	Yes	Yes	19	8	7
241	R:R:F270	R:R:Q193	4.68	Yes	Yes	19	7	9
242	R:R:Q193	R:R:S296	4.33	Yes	No	19	9	8
243	R:R:E297	R:R:Q193	5.1	No	Yes	0	8	9
244	R:R:Q193	R:R:Y489	5.64	Yes	Yes	0	9	8
245	R:R:A194	R:R:K225	3.21	No	No	0	7	3
246	R:R:E229	R:R:T195	12.7	No	No	0	5	4
247	R:R:A196	R:R:Y511	9.34	No	Yes	0	8	5
248	R:R:M197	R:R:V268	3.04	No	No	0	7	6
249	R:R:F320	R:R:M197	4.98	No	No	0	6	7
250	R:R:D199	R:R:R233	5.96	No	Yes	0	7	4
251	R:R:D199	R:R:Y511	3.45	No	Yes	0	7	5
252	R:R:I200	R:R:L521	4.28	No	No	5	8	5
253	R:R:I200	R:R:I523	4.42	No	Yes	5	8	6
254	R:R:I201	R:R:W206	4.7	Yes	Yes	5	6	9
255	R:R:I201	R:R:V209	4.61	Yes	Yes	5	6	8
256	R:R:I201	R:R:I235	4.42	Yes	Yes	5	6	7
257	R:R:I201	R:R:V266	3.07	Yes	Yes	5	6	7
258	R:R:E202	R:R:R233	8.14	No	Yes	0	5	4
259	R:R:F204	R:R:Y203	8.25	Yes	No	5	7	5
260	R:R:L521	R:R:Y203	3.52	No	No	5	5	5
261	R:R:I523	R:R:Y203	10.88	Yes	No	5	6	5
262	R:R:F204	R:R:W206	11.02	Yes	Yes	5	7	9
263	R:R:F204	R:R:I523	5.02	Yes	Yes	5	7	6
264	R:R:E525	R:R:F204	5.83	No	Yes	0	4	7
265	R:R:F204	R:R:W530	10.02	Yes	Yes	5	7	8
266	H:H:?3	R:R:R205	4.33	Yes	No	6	0	4
267	H:H:?4	R:R:R205	5.42	No	No	6	0	4
268	R:R:V266	R:R:W206	15.94	Yes	Yes	5	7	9
269	R:R:I292	R:R:W206	3.52	No	Yes	5	7	9
270	R:R:W206	R:R:W530	3.75	Yes	Yes	5	9	8
271	R:R:S540	R:R:W206	11.12	No	Yes	5	9	9
272	R:R:C236	R:R:N207	3.15	No	Yes	6	9	6
273	R:R:N207	R:R:N541	10.9	Yes	No	6	6	5
274	R:R:C561	R:R:N207	4.72	No	Yes	6	9	6
275	H:H:?3	R:R:N207	15.92	Yes	Yes	6	0	6
276	R:R:C236	R:R:W208	5.22	No	Yes	6	9	9
277	R:R:D238	R:R:W208	13.4	No	Yes	6	8	9
278	R:R:A264	R:R:W208	3.89	No	Yes	0	7	9
279	R:R:C542	R:R:W208	18.28	No	Yes	6	9	9
280	R:R:P559	R:R:W208	5.4	No	Yes	0	6	9
281	R:R:C562	R:R:W208	6.53	Yes	Yes	6	9	9
282	R:R:G210	R:R:V209	3.68	No	Yes	0	8	8
283	R:R:I235	R:R:V209	3.07	Yes	Yes	5	7	8
284	R:R:V209	R:R:V266	6.41	Yes	Yes	5	8	7
285	R:R:F239	R:R:G210	9.03	Yes	No	0	6	8
286	R:R:I223	R:R:T211	7.6	No	No	0	5	5
287	R:R:I237	R:R:T211	3.04	No	No	0	6	5
288	R:R:S240	R:R:T211	3.2	No	No	0	4	5
289	R:R:I212	R:R:I243	4.42	No	No	0	6	5
290	R:R:A213	R:R:I223	4.87	No	No	0	4	5
291	R:R:A214	R:R:S271	3.42	No	No	0	5	4
292	R:R:A214	R:R:D275	4.63	No	No	0	5	5
293	R:R:D215	R:R:R220	8.34	No	No	0	6	6
294	R:R:D215	R:R:L242	6.79	No	No	0	6	4
295	R:R:D215	S:S:R172	9.53	No	No	0	6	4
296	R:R:D216	R:R:Y218	3.45	No	Yes	0	6	7
297	R:R:G219	R:R:Y218	4.35	No	Yes	0	7	7
298	R:R:F270	R:R:Y218	9.28	Yes	Yes	19	7	7
299	R:R:S296	R:R:Y218	7.63	No	Yes	19	8	7
300	R:R:A298	R:R:Y218	4	No	Yes	0	6	7
301	R:R:R220	S:S:L173	8.5	No	No	0	6	5
302	R:R:F270	R:R:G222	4.52	Yes	No	0	7	7
303	R:R:F270	R:R:I223	3.77	Yes	No	0	7	5
304	R:R:E224	R:R:R227	11.63	No	Yes	0	6	4
305	R:R:E224	S:S:E224	17.76	No	No	0	6	6
306	R:R:E229	R:R:K225	16.2	No	No	0	5	3
307	R:R:A230	R:R:F226	5.55	No	No	0	6	6
308	R:R:F226	R:R:V268	5.24	No	No	0	6	6
309	R:R:I237	R:R:R227	11.27	No	Yes	0	6	4
310	R:R:R227	R:R:S240	7.91	Yes	No	0	4	4
311	R:R:R227	S:S:R227	3.2	Yes	Yes	0	4	4
312	R:R:A230	R:R:I235	6.5	No	Yes	0	6	7
313	R:R:I235	R:R:R233	3.76	Yes	Yes	0	7	4
314	R:R:K517	R:R:R233	3.71	No	Yes	0	1	4
315	R:R:D234	S:S:G557	3.35	No	No	33	5	6
316	R:R:D234	W:W:?1103	7.48	No	No	33	5	0
317	R:R:C236	R:R:C561	7.28	No	No	6	9	9
318	R:R:D238	R:R:F239	9.55	No	Yes	6	8	6
319	R:R:D238	R:R:S262	8.83	No	No	6	8	7
320	R:R:F239	R:R:V258	3.93	Yes	No	0	6	4
321	R:R:F239	R:R:S262	5.28	Yes	No	6	6	7
322	R:R:E241	R:R:H254	6.15	No	No	0	5	3
323	R:R:E241	R:R:V255	5.7	No	Yes	0	5	5
324	R:R:I243	R:R:V255	3.07	No	Yes	0	5	5
325	R:R:Q245	R:R:Y246	16.91	No	No	0	4	3
326	R:R:D275	R:R:Q245	6.53	No	No	0	5	4
327	R:R:Y246	S:S:N178	12.79	No	No	0	3	3
328	R:R:I252	R:R:S247	4.64	No	No	0	4	2
329	R:R:D248	R:R:E250	3.9	No	No	0	3	2
330	R:R:D248	R:R:E251	3.9	No	No	0	3	4
331	R:R:E249	R:R:Q253	5.1	No	No	0	2	3
332	R:R:E257	R:R:Q253	6.37	No	No	0	3	3
333	R:R:Q253	R:R:R286	7.01	No	Yes	0	3	4
334	R:R:H254	R:R:V258	4.15	No	No	0	3	4
335	R:R:L279	R:R:V255	4.47	No	Yes	0	5	5
336	R:R:E282	R:R:V256	12.84	No	No	27	6	5
337	R:R:I283	R:R:V256	3.07	Yes	No	0	4	5
338	R:R:R286	R:R:V256	6.54	Yes	No	27	4	5
339	R:R:Q260	R:R:R286	8.18	No	Yes	0	5	4
340	R:R:I288	R:R:Q260	9.61	No	No	0	4	5
341	H:H:?11	R:R:N261	30.62	No	No	0	0	4
342	R:R:K265	R:R:S540	3.06	No	No	0	5	9
343	R:R:I292	R:R:V266	3.07	No	Yes	5	7	7
344	R:R:L294	R:R:V266	4.47	No	Yes	0	7	7
345	R:R:S540	R:R:V266	4.85	No	Yes	5	9	7
346	R:R:I267	R:R:K291	5.82	No	No	0	7	6
347	R:R:I267	R:R:W293	8.22	No	No	0	7	8
348	R:R:L294	R:R:V268	4.47	No	No	0	7	6
349	R:R:L276	R:R:V269	4.47	No	No	14	5	5
350	R:R:V269	R:R:W299	9.81	No	Yes	14	5	7
351	R:R:F270	R:R:S296	6.61	Yes	No	19	7	8
352	R:R:G273	R:R:S272	3.71	No	No	0	4	5
353	R:R:G273	R:R:P274	4.06	No	Yes	0	4	3
354	R:R:L304	R:R:P274	3.28	No	Yes	32	2	3
355	R:R:I280	R:R:L276	7.14	Yes	No	0	5	5
356	R:R:L276	R:R:W299	10.25	No	Yes	14	5	7
357	R:R:E277	R:R:P278	3.14	No	No	0	2	2
358	R:R:E277	R:R:K281	10.8	No	No	0	2	2
359	R:R:E277	R:R:L304	5.3	No	No	0	2	2
360	R:R:I283	R:R:L279	4.28	Yes	No	0	4	5
361	R:R:I280	R:R:I305	7.36	Yes	No	0	5	4
362	R:R:I280	R:R:Y310	3.63	Yes	Yes	0	5	3
363	R:R:I280	R:R:V314	3.07	Yes	No	0	5	7
364	R:R:E282	R:R:R285	4.65	No	No	27	6	3
365	R:R:E282	R:R:R286	12.79	No	Yes	27	6	4
366	R:R:I283	R:R:W293	3.52	Yes	No	0	4	8
367	R:R:I283	R:R:V313	4.61	Yes	No	0	4	3
368	R:R:V284	R:R:Y310	8.83	No	Yes	0	3	3
369	R:R:R285	R:R:R286	5.33	No	Yes	27	3	4
370	H:H:?12	R:R:N287	29.4	No	No	0	0	6
371	R:R:G290	R:R:T289	3.64	No	No	0	4	5
372	R:R:I292	R:R:W530	3.52	No	Yes	5	7	8
373	R:R:T317	R:R:W293	3.64	No	No	0	7	8
374	R:R:A295	R:R:W299	6.48	No	Yes	0	7	7
375	R:R:E297	R:R:L322	14.58	No	No	0	8	4
376	R:R:E297	W:W:W1101	6.54	No	Yes	0	8	0
377	R:R:A298	W:W:W1101	6.48	No	Yes	0	6	0
378	R:R:I305	R:R:W299	5.87	No	Yes	14	4	7
379	R:R:W299	R:R:W494	3.75	Yes	Yes	14	7	7
380	L:L:?1102	R:R:S302	5.51	No	No	0	0	5
381	R:R:P407	R:R:S303	3.56	No	No	0	1	3
382	R:R:I305	R:R:W494	3.52	No	Yes	14	4	7
383	R:R:A306	R:R:W494	5.19	No	Yes	14	4	7
384	R:R:A306	R:R:I503	4.87	No	Yes	14	4	4
385	R:R:M307	R:R:P308	3.35	No	No	0	3	2
386	R:R:M307	R:R:Q309	5.44	No	No	34	3	3
387	R:R:M307	R:R:Y310	7.18	No	Yes	34	3	3
388	R:R:Q309	R:R:Y310	4.51	No	Yes	34	3	3
389	R:R:F311	R:R:G315	4.52	No	No	0	3	4
390	R:R:F311	R:R:L496	7.31	No	No	0	3	3
391	R:R:F311	R:R:I503	5.02	No	Yes	0	3	4
392	R:R:V314	R:R:W494	3.68	No	Yes	0	7	7
393	R:R:G316	R:R:N493	3.39	No	No	0	8	9
394	R:R:T317	R:R:W494	18.19	No	Yes	0	7	7
395	R:R:F320	R:R:Y489	3.09	No	Yes	0	6	8
396	R:R:F320	R:R:I491	6.28	No	No	0	6	8
397	R:R:A321	R:R:R415	6.91	No	No	0	5	5
398	R:R:A324	R:R:H413	4.39	No	No	0	5	7
399	R:R:G325	R:R:Y418	7.24	No	Yes	0	4	7
400	R:R:I327	R:R:P328	3.39	Yes	No	0	6	4
401	R:R:F330	R:R:I327	6.28	Yes	Yes	13	8	6
402	R:R:I327	R:R:L414	4.28	Yes	Yes	13	6	6
403	R:R:I327	R:R:Y421	9.67	Yes	Yes	13	6	8
404	R:R:F330	R:R:L334	10.96	Yes	No	0	8	6
405	R:R:F330	R:R:L414	4.87	Yes	Yes	13	8	6
406	R:R:F330	R:R:S417	3.96	Yes	No	13	8	6
407	R:R:K335	R:R:R331	3.71	No	No	0	4	4
408	R:R:R331	R:R:Y411	15.43	No	Yes	0	4	5
409	R:R:L334	R:R:Y408	9.38	No	Yes	0	6	3
410	R:R:L334	R:R:Y411	3.52	No	Yes	0	6	5
411	R:R:I409	R:R:K335	5.82	No	No	0	5	4
412	R:R:H338	R:R:P339	10.68	No	Yes	0	4	7
413	R:R:H338	R:R:R340	3.39	No	No	0	4	4
414	R:R:H338	R:R:K341	20.96	No	No	0	4	3
415	R:R:P339	R:R:W352	25.67	Yes	Yes	0	7	8
416	R:R:L360	R:R:P339	3.28	No	Yes	0	4	7
417	R:R:N345	R:R:S342	2.98	No	No	0	8	3
418	R:R:H344	R:R:V343	6.92	No	No	0	3	3
419	R:R:F347	R:R:N345	3.62	Yes	No	0	5	8
420	R:R:F351	R:R:T355	9.08	Yes	Yes	1	6	4
421	R:R:F351	R:R:Y408	11.35	Yes	Yes	1	6	3
422	R:R:F356	R:R:W352	17.04	Yes	Yes	1	8	8
423	R:R:G397	R:R:W352	4.22	No	Yes	1	5	8
424	R:R:E399	R:R:W352	6.54	Yes	Yes	1	8	8
425	R:R:F356	R:R:T355	9.08	Yes	Yes	1	8	4
426	R:R:T355	R:R:T406	3.14	Yes	No	1	4	4
427	R:R:E399	R:R:F356	16.32	Yes	Yes	1	8	8
428	R:R:C358	R:R:C395	7.28	No	No	0	9	9
429	R:R:E362	R:R:L360	5.3	No	No	0	1	4
430	R:R:L394	R:R:Q361	9.32	No	No	0	1	1
431	R:R:C395	R:R:E399	4.56	No	Yes	0	9	8
432	R:R:E399	R:R:T396	4.23	Yes	No	0	8	6
433	R:R:D398	R:R:G397	3.35	No	No	0	3	5
434	R:R:E399	R:R:G397	3.27	Yes	No	1	8	5
435	R:R:N400	R:R:S402	7.45	No	No	0	4	4
436	R:R:N400	R:R:S403	4.47	No	No	0	4	2
437	R:R:S403	R:R:V404	3.23	No	No	0	2	4
438	R:R:D410	R:R:E405	6.5	No	No	0	6	4
439	R:R:P407	R:R:T406	3.5	No	No	0	1	4
440	R:R:L414	R:R:Y411	7.03	Yes	Yes	0	6	5
441	R:R:H413	R:R:T412	6.85	No	No	0	7	5
442	R:R:H413	R:R:R415	9.03	No	No	0	7	5
443	R:R:L414	R:R:S417	4.5	Yes	No	13	6	6
444	R:R:I416	W:W:W1101	3.52	No	Yes	0	4	0
445	R:R:L422	R:R:Y418	5.86	No	Yes	20	8	7
446	R:R:N471	R:R:Y418	4.65	Yes	Yes	20	6	7
447	R:R:N472	R:R:Y418	3.49	No	Yes	20	4	7
448	R:R:M473	R:R:Y418	4.79	No	Yes	20	4	7
449	R:R:Y421	R:R:Y425	13.9	Yes	No	13	8	8
450	R:R:L422	R:R:N471	4.12	No	Yes	20	8	6
451	R:R:L467	R:R:S426	3	No	No	0	7	7
452	R:R:F479	R:R:S426	5.28	No	No	0	8	7
453	R:R:F469	R:R:H429	21.5	No	No	0	8	6
454	R:R:Q432	R:R:T436	4.25	No	No	0	7	4
455	R:R:I434	R:R:I452	4.42	No	No	0	6	3
456	R:R:I434	R:R:V455	3.07	No	No	0	6	4
457	R:R:H463	R:R:I434	13.26	No	No	0	5	6
458	R:R:T436	R:R:Y435	4.99	No	No	0	4	3
459	R:R:I452	R:R:Y435	3.63	No	No	0	3	3
460	R:R:C437	R:R:C449	7.28	No	No	0	6	7
461	R:R:L438	R:R:P439	3.28	No	No	0	3	2
462	R:R:C449	R:R:G442	3.92	No	No	0	7	4
463	R:R:H463	R:R:L443	5.14	No	No	0	5	3
464	R:R:H466	R:R:L443	6.43	No	No	0	4	3
465	R:R:F444	R:R:Q459	9.37	Yes	Yes	0	3	7
466	R:R:F444	R:R:K462	3.72	Yes	No	0	3	4
467	R:R:F444	R:R:H463	5.66	Yes	No	0	3	5
468	H:H:?13	R:R:N446	35.52	No	No	0	0	3
469	R:R:A450	R:R:Q459	4.55	No	Yes	0	3	7
470	R:R:D451	R:R:K454	4.15	No	No	0	3	3
471	R:R:E456	R:R:W458	14.17	No	Yes	18	5	4
472	R:R:E456	R:R:Q459	6.37	No	Yes	18	5	7
473	R:R:E456	S:S:R54	3.49	No	No	18	5	2
474	R:R:Q459	R:R:W458	12.05	Yes	Yes	18	7	4
475	R:R:W458	S:S:L51	3.42	Yes	Yes	18	4	6
476	R:R:W458	S:S:R54	9	Yes	No	18	4	2
477	R:R:W458	S:S:P55	12.16	Yes	No	18	4	6
478	R:R:H466	R:R:K462	9.17	No	No	0	4	4
479	R:R:R465	S:S:L51	7.29	No	Yes	0	5	6
480	R:R:F469	R:R:L467	3.65	No	No	0	8	7
481	R:R:N468	R:R:Q476	3.96	No	No	0	6	3
482	H:H:?14	R:R:N468	26.95	No	No	0	0	6
483	R:R:F469	R:R:V477	9.18	No	No	0	8	6
484	R:R:Q476	R:R:T470	9.92	No	No	0	3	5
485	R:R:E475	R:R:N471	3.94	No	Yes	0	5	6
486	R:R:N471	R:R:V477	5.91	Yes	No	0	6	6
487	R:R:M473	R:R:N472	5.61	No	No	20	4	4
488	R:R:L485	R:R:V477	5.96	No	No	0	4	6
489	H:H:?14	R:R:T478	3.94	No	No	0	0	3
490	R:R:F479	R:R:L485	6.09	No	No	0	8	4
491	R:R:D480	R:R:D484	3.99	No	No	0	7	8
492	R:R:V486	R:R:Y514	3.79	No	Yes	0	3	4
493	R:R:N488	R:R:N512	5.45	Yes	Yes	21	4	4
494	R:R:N488	R:R:V513	5.91	Yes	No	0	4	3
495	R:R:N488	R:R:Y514	6.98	Yes	Yes	21	4	4
496	H:H:?1	R:R:N488	28.17	Yes	Yes	21	0	4
497	R:R:Y489	R:R:Y511	2.98	Yes	Yes	0	8	5
498	R:R:E507	R:R:S490	8.62	No	No	0	5	8
499	R:R:I491	R:R:V508	3.07	No	No	0	8	7
500	R:R:I492	R:R:W494	3.52	No	Yes	14	5	7
501	R:R:F505	R:R:I492	6.28	No	No	14	4	5
502	R:R:H495	R:R:N493	7.65	Yes	No	0	7	9
503	R:R:I528	R:R:N493	5.66	No	No	0	7	9
504	R:R:I503	R:R:W494	3.52	Yes	Yes	14	4	7
505	R:R:F505	R:R:W494	11.02	No	Yes	14	4	7
506	R:R:H495	R:R:K506	6.55	Yes	No	0	7	5
507	R:R:H495	R:R:L529	11.57	Yes	No	0	7	4
508	R:R:P498	R:R:S497	3.56	No	Yes	35	3	3
509	R:R:E499	R:R:S497	5.75	No	Yes	35	4	3
510	R:R:G501	R:R:S497	3.71	No	Yes	0	5	3
511	R:R:S497	R:R:V504	3.23	Yes	No	0	3	3
512	R:R:E499	R:R:P498	3.14	No	No	35	4	3
513	R:R:F505	R:R:I503	3.77	No	Yes	14	4	4
514	R:R:K527	R:R:V508	3.04	No	No	0	3	7
515	R:R:I528	R:R:V508	6.14	No	No	0	7	7
516	R:R:F522	R:R:Y510	14.44	No	No	0	1	3
517	H:H:?1	R:R:Y510	13.59	Yes	No	0	0	3
518	R:R:R520	R:R:Y511	7.2	No	Yes	0	3	5
519	R:R:N512	R:R:Y514	3.49	Yes	Yes	21	4	4
520	R:R:A515	R:R:N512	3.13	No	Yes	0	4	4
521	H:H:?1	R:R:N512	18.37	Yes	Yes	21	0	4
522	H:H:?2	R:R:N512	3.67	No	Yes	21	0	4
523	H:H:?1	R:R:Y514	11.5	Yes	Yes	21	0	4
524	R:R:E519	R:R:K516	6.75	No	No	0	4	2
525	R:R:I523	R:R:L521	8.56	Yes	No	5	6	5
526	R:R:E526	R:R:N524	5.26	No	No	0	3	5
527	R:R:K527	R:R:N524	6.99	No	No	0	3	5
528	R:R:I528	R:R:W530	14.09	No	Yes	0	7	8
529	R:R:L529	R:R:R535	3.64	No	No	0	4	4
530	R:R:V537	R:R:W530	4.9	No	Yes	5	4	8
531	R:R:P538	R:R:W530	14.86	No	Yes	5	8	8
532	R:R:E536	R:R:S534	4.31	No	No	0	5	4
533	R:R:P538	R:R:V537	3.53	No	No	5	8	4
534	R:R:F539	R:R:N541	7.25	No	No	6	1	5
535	R:R:F539	R:R:R544	27.79	No	No	0	1	5
536	H:H:?3	R:R:F539	4.35	Yes	No	6	0	1
537	H:H:?3	R:R:N541	25.72	Yes	No	6	0	5
538	R:R:C542	R:R:C562	7.28	No	Yes	6	9	9
539	R:R:D545	R:R:D578	10.65	No	No	0	5	7
540	R:R:C546	R:R:T550	6.76	No	No	36	9	6
541	R:R:C546	R:R:C565	7.28	No	No	36	9	9
542	R:R:C565	R:R:T550	3.38	No	No	36	9	6
543	R:R:R551	R:R:V566	7.85	No	No	0	7	4
544	R:R:R551	S:S:R551	18.13	No	No	0	7	7
545	R:R:F563	R:R:K552	16.13	No	No	0	7	8
546	R:R:K552	R:R:S580	3.06	No	No	37	8	4
547	R:R:K552	S:S:E556	4.05	No	No	37	8	6
548	R:R:I554	S:S:I554	10.3	No	No	0	3	3
549	R:R:I554	S:S:S580	3.1	No	No	0	3	4
550	R:R:E558	R:R:I555	9.56	No	No	0	5	5
551	R:R:E556	S:S:K552	4.05	No	No	38	6	8
552	R:R:E556	S:S:D578	3.9	No	No	0	6	7
553	R:R:E556	S:S:S580	5.75	No	No	38	6	4
554	R:R:G557	S:S:D234	3.35	No	No	39	6	5
555	R:R:G557	X:X:?1108	3.14	No	No	39	6	0
556	R:R:E558	R:R:P559	3.14	No	No	0	5	6
557	R:R:C562	R:R:E558	3.04	Yes	No	0	9	5
558	R:R:T560	S:S:T560	4.71	No	No	0	4	4
559	R:R:E564	R:R:V566	4.28	No	No	0	6	4
560	R:R:E567	R:R:H595	8.62	No	No	0	4	5
561	R:R:C568	R:R:E572	13.67	Yes	Yes	28	9	7
562	R:R:C568	R:R:C582	7.28	Yes	No	28	9	9
563	R:R:D570	R:R:P569	9.66	No	No	0	5	5
564	R:R:D570	S:S:D570	3.99	No	No	0	5	5
565	R:R:C585	R:R:G571	3.92	Yes	No	0	9	7
566	R:R:G571	R:R:S591	3.71	No	No	0	7	8
567	R:R:E572	R:R:S574	10.06	Yes	No	28	7	8
568	R:R:C582	R:R:E572	13.67	No	Yes	28	9	7
569	R:R:E572	R:R:H595	3.69	Yes	No	0	7	5
570	R:R:D575	R:R:Y573	8.05	No	Yes	0	8	6
571	R:R:N583	R:R:Y573	31.4	No	Yes	0	1	6
572	R:R:C585	R:R:Y573	8.06	Yes	Yes	40	9	6
573	R:R:C598	R:R:Y573	6.72	No	Yes	40	9	6
574	R:R:C582	R:R:S574	5.16	No	No	28	9	8
575	R:R:D575	R:R:E576	3.9	No	No	0	8	3
576	R:R:D575	R:R:S597	7.36	No	No	0	8	1
577	R:R:A579	R:R:E576	4.53	No	No	0	7	3
578	R:R:D578	R:R:T577	4.34	No	No	0	7	5
579	R:R:D578	S:S:E556	3.9	No	No	0	7	6
580	R:R:S580	S:S:I554	3.1	No	No	0	4	3
581	R:R:S580	S:S:E556	5.75	No	No	37	4	6
582	R:R:C585	R:R:C598	7.28	Yes	No	40	9	9
583	R:R:F589	R:R:P586	7.22	No	No	0	5	4
584	R:R:D588	R:R:E602	5.2	No	No	41	6	3
585	R:R:D588	R:R:I761	5.6	No	No	41	6	7
586	R:R:E757	R:R:W590	4.36	No	No	0	4	6
587	R:R:D758	R:R:W590	15.63	No	No	0	4	6
588	R:R:H595	R:R:S591	4.18	No	No	0	5	8
589	R:R:N592	R:R:N594	4.09	No	No	0	7	3
590	R:R:N594	R:R:T596	4.39	No	No	0	3	5
591	R:R:E604	R:R:K601	9.45	No	No	0	6	8
592	R:R:E602	R:R:Q754	3.82	No	No	0	3	4
593	R:R:E602	R:R:I761	13.66	No	No	41	3	7
594	R:R:F605	R:R:I603	33.91	No	No	0	7	4
595	R:R:E759	R:R:I603	5.47	No	No	0	4	4
596	R:R:F605	R:R:F762	8.57	No	Yes	0	7	7
597	R:R:E671	R:R:L606	15.9	No	No	0	4	9
598	R:R:K831	R:R:S607	7.65	No	No	0	9	7
599	R:R:T609	R:R:W608	9.7	No	No	0	4	5
600	R:R:G670	R:R:W608	4.22	No	No	0	7	5
601	R:R:E671	R:R:W608	3.27	No	No	0	4	5
602	R:R:E610	R:R:P611	6.29	No	No	0	7	4
603	R:R:I614	R:R:T617	6.08	No	No	0	6	5
604	R:R:I839	R:R:L616	5.71	No	No	0	7	8
605	R:R:I669	R:R:T617	4.56	No	No	0	8	5
606	R:R:F619	R:R:L842	9.74	No	Yes	0	3	9
607	R:R:A620	R:R:L842	4.73	No	Yes	0	7	9
608	R:R:F662	R:R:G623	9.03	Yes	No	0	8	6
609	R:R:I624	R:R:T627	3.04	No	No	0	5	7
610	R:R:I624	R:R:S663	3.1	No	No	0	5	6
611	R:R:F625	R:R:F629	34.29	No	No	0	3	3
612	R:R:L659	R:R:T627	5.9	No	No	0	4	7
613	R:R:V630	R:R:V633	3.21	Yes	No	11	7	5
614	R:R:F634	R:R:V630	9.18	Yes	Yes	11	9	7
615	R:R:F853	R:R:V630	11.8	Yes	Yes	11	9	7
616	R:R:I857	R:R:V630	6.14	Yes	Yes	11	8	7
617	R:R:I635	R:R:L631	7.14	No	No	0	4	4
618	R:R:L631	R:R:L655	5.54	No	Yes	0	4	9
619	R:R:G632	R:R:I635	3.53	No	No	0	1	4
620	R:R:I857	R:R:V633	6.14	Yes	No	11	8	5
621	R:R:F634	R:R:L655	3.65	Yes	Yes	11	9	9
622	R:R:F634	R:R:F853	16.08	Yes	Yes	11	9	9
623	R:R:F634	R:R:I857	13.82	Yes	Yes	11	9	8
624	R:R:E649	R:R:F725	27.98	No	No	3	7	5
625	R:R:E649	R:R:L726	11.93	No	No	3	7	4
626	R:R:L650	R:R:V697	2.98	No	No	0	8	8
627	R:R:L653	R:R:Y652	5.86	No	No	0	5	7
628	R:R:L654	R:R:S693	10.51	No	No	0	8	9
629	R:R:F853	R:R:L655	6.09	Yes	Yes	11	9	9
630	R:R:C660	R:R:F656	5.59	No	No	0	7	4
631	R:R:S657	R:R:V689	6.46	No	No	0	9	7
632	R:R:L690	R:R:S657	3	Yes	No	0	7	9
633	R:R:L658	R:R:L690	4.15	No	Yes	11	8	7
634	R:R:L658	R:R:L849	17.99	No	No	11	8	8
635	R:R:F853	R:R:L658	4.87	Yes	No	11	9	8
636	R:R:C660	R:R:I686	6.55	No	Yes	0	7	7
637	R:R:C661	R:R:I686	6.55	No	Yes	0	7	7
638	R:R:C661	R:R:S687	5.16	No	No	11	7	6
639	R:R:C661	R:R:L690	9.52	No	Yes	11	7	7
640	R:R:F662	R:R:L842	3.65	Yes	Yes	0	8	9
641	R:R:F662	R:R:S845	7.93	Yes	No	0	8	8
642	R:R:I686	R:R:S664	3.1	Yes	No	0	7	6
643	R:R:I841	R:R:S665	3.1	No	No	0	9	8
644	R:R:L842	R:R:S665	4.5	Yes	No	0	9	8
645	R:R:F667	R:R:L666	14.61	No	No	0	5	7
646	R:R:F668	R:R:R680	13.9	Yes	No	0	9	8
647	R:R:F668	R:R:S834	5.28	Yes	No	0	9	8
648	R:R:E837	R:R:F668	7	No	Yes	0	9	9
649	R:R:F668	R:R:V838	5.24	Yes	No	0	9	7
650	R:R:P672	R:R:S750	5.34	Yes	No	22	9	6
651	R:R:I763	R:R:P672	8.47	No	Yes	0	7	9
652	R:R:C765	R:R:P672	3.77	Yes	Yes	22	9	9
653	R:R:T676	R:R:W675	8.49	No	No	0	7	3
654	R:R:C677	R:R:R680	4.18	No	No	22	9	8
655	R:R:C677	R:R:S750	5.16	No	No	22	9	6
656	R:R:C677	R:R:C765	7.28	No	Yes	22	9	9
657	R:R:Q681	R:R:R678	17.52	No	No	3	9	5
658	R:R:L743	R:R:R678	23.08	No	No	3	7	5
659	R:R:P748	R:R:R678	10.09	No	No	0	9	5
660	R:R:L679	R:R:P682	9.85	No	No	0	5	5
661	R:R:C765	R:R:R680	9.75	Yes	No	22	9	8
662	R:R:C739	R:R:Q681	7.63	No	No	3	7	9
663	R:R:L743	R:R:Q681	11.98	No	No	3	7	9
664	R:R:F684	R:R:F775	6.43	Yes	Yes	3	8	4
665	R:R:F684	R:R:L776	26.79	Yes	No	3	8	8
666	R:R:F684	R:R:Y779	25.79	Yes	Yes	3	8	9
667	R:R:F684	R:R:W818	3.01	Yes	Yes	0	8	9
668	R:R:F775	R:R:G685	3.01	Yes	No	0	4	8
669	R:R:L690	R:R:S687	4.5	Yes	No	11	7	6
670	R:R:C731	R:R:F688	13.97	No	Yes	3	5	8
671	R:R:F688	R:R:Q735	9.37	Yes	Yes	3	8	9
672	R:R:F688	R:R:Y779	7.22	Yes	Yes	3	8	9
673	R:R:F688	R:R:L783	13.4	Yes	No	3	8	9
674	R:R:T732	R:R:V689	9.52	No	No	0	7	7
675	R:R:C691	R:R:L783	4.76	No	No	0	8	9
676	R:R:I692	R:R:I695	5.89	Yes	No	0	7	7
677	R:R:I692	R:R:L696	12.85	Yes	No	3	7	8
678	R:R:I692	R:R:V728	10.75	Yes	No	3	7	7
679	R:R:C694	R:R:C787	7.28	No	No	0	6	8
680	R:R:L696	R:R:V728	4.47	No	No	3	8	7
681	R:R:I807	R:R:V697	3.07	Yes	No	0	9	8
682	R:R:I807	R:R:K698	13.09	Yes	No	0	9	9
683	R:R:L727	R:R:Q724	6.65	No	No	0	7	8
684	R:R:F725	R:R:L726	15.83	No	No	3	5	4
685	R:R:L727	R:R:L730	4.15	No	No	0	7	3
686	R:R:C731	R:R:L783	3.17	No	No	3	5	9
687	R:R:I736	R:R:T732	3.04	No	No	0	5	7
688	R:R:F733	R:R:V737	6.55	No	No	0	4	3
689	R:R:I738	R:R:Q735	6.86	No	Yes	3	8	9
690	R:R:C739	R:R:Q735	4.58	No	Yes	3	7	9
691	R:R:F775	R:R:Q735	35.14	Yes	Yes	3	4	9
692	R:R:Q735	R:R:Y779	12.4	Yes	Yes	3	9	9
693	R:R:I741	R:R:V737	3.07	No	No	0	4	3
694	R:R:I738	R:R:W742	8.22	No	Yes	3	8	9
695	R:R:F775	R:R:I738	7.54	Yes	No	3	4	8
696	R:R:C739	R:R:F775	8.38	No	Yes	3	7	4
697	R:R:I741	R:R:W742	8.22	No	Yes	0	4	9
698	R:R:T745	R:R:W742	9.7	No	Yes	3	4	9
699	R:R:M771	R:R:W742	27.92	Yes	Yes	3	3	9
700	R:R:M771	R:R:T745	10.54	Yes	No	3	3	4
701	R:R:A746	R:R:M771	3.22	No	Yes	0	6	3
702	R:R:C765	R:R:S750	5.16	Yes	No	22	9	6
703	R:R:N753	R:R:Y751	5.81	Yes	No	0	7	3
704	R:R:H766	R:R:Y751	4.36	No	No	0	6	3
705	R:R:E755	R:R:N753	3.94	No	Yes	42	4	7
706	R:R:F762	R:R:N753	3.62	Yes	Yes	42	7	7
707	R:R:N753	R:R:T764	11.7	Yes	No	0	7	7
708	R:R:I760	R:R:Q754	6.86	No	No	0	5	4
709	R:R:E755	R:R:F762	7	No	Yes	42	4	7
710	R:R:E755	R:R:Y829	3.37	No	No	0	4	6
711	R:R:I760	R:R:L756	8.56	No	No	0	5	5
712	R:R:D758	R:R:E759	6.5	No	No	0	4	4
713	R:R:F762	R:R:I760	10.05	Yes	No	0	7	5
714	R:R:E767	R:R:Y825	4.49	No	Yes	0	7	9
715	R:R:L770	R:R:M771	7.07	No	Yes	0	3	3
716	R:R:I777	R:R:L773	7.14	No	No	0	8	8
717	R:R:F775	R:R:Y779	17.54	Yes	Yes	3	4	9
718	R:R:L776	R:R:Y779	16.41	No	Yes	3	8	9
719	R:R:L776	R:R:T780	4.42	No	No	3	8	7
720	R:R:T780	R:R:Y779	23.72	No	Yes	3	7	9
721	R:R:T780	R:R:W818	7.28	No	Yes	0	7	9
722	R:R:I786	R:R:L782	7.14	No	No	0	4	4
723	R:R:F790	R:R:I786	3.77	No	No	0	7	4
724	R:R:C787	R:R:M811	8.1	No	No	0	8	9
725	R:R:F792	R:R:K796	4.96	No	No	0	8	7
726	R:R:A804	R:R:S794	3.42	No	No	0	9	9
727	R:R:K796	R:R:R795	3.71	No	No	0	7	9
728	R:R:K805	R:R:R795	27.23	No	No	0	9	9
729	R:R:R795	R:R:T808	10.35	No	No	0	9	9
730	R:R:L797	R:R:P798	4.93	No	No	0	8	9
731	R:R:F801	R:R:I859	15.07	No	No	0	9	9
732	R:R:K805	R:R:N802	4.2	No	No	0	9	9
733	R:R:F806	R:R:N802	20.54	No	No	0	5	9
734	R:R:E803	R:R:I807	6.83	No	Yes	0	9	9
735	R:R:E803	R:R:K856	13.5	No	No	0	9	9
736	R:R:F806	R:R:N855	27.79	No	No	0	5	9
737	R:R:F809	R:R:I813	6.28	No	No	0	9	8
738	R:R:C851	R:R:F809	4.19	No	No	0	8	9
739	R:R:L848	R:R:S810	3	No	No	0	7	9
740	R:R:C851	R:R:S810	3.44	No	No	0	8	9
741	R:R:I852	R:R:S810	3.1	No	No	0	9	9
742	R:R:F814	R:R:W818	23.05	Yes	Yes	0	9	9
743	R:R:F814	R:R:L848	4.87	Yes	No	0	9	7
744	R:R:F815	R:R:I819	13.82	No	No	0	7	6
745	R:R:I816	S:S:I816	4.42	No	No	0	8	8
746	R:R:A843	R:R:V817	3.39	No	No	0	7	9
747	R:R:A844	R:R:V817	3.39	No	No	0	9	9
748	R:R:F821	R:R:W818	9.02	Yes	Yes	0	9	9
749	R:R:F821	R:R:I822	7.54	Yes	No	0	9	7
750	R:R:F821	R:R:Y825	8.25	Yes	Yes	0	9	9
751	R:R:E837	R:R:F821	4.66	No	Yes	0	9	9
752	R:R:A840	R:R:F821	4.16	No	Yes	0	9	9
753	R:R:I822	R:R:P823	3.39	No	No	0	7	9
754	R:R:V833	R:R:Y825	3.79	No	Yes	0	6	9
755	R:R:V836	R:R:Y825	3.79	No	Yes	0	8	9
756	R:R:S827	S:S:T828	3.2	No	No	0	8	8
757	R:R:T828	R:R:V833	3.17	No	No	0	8	6
758	R:R:T828	S:S:S827	3.2	No	No	0	8	8
759	R:R:G830	R:R:V833	3.68	No	No	0	8	6
760	R:R:E837	R:R:I841	4.1	No	No	0	9	9
761	R:R:F853	R:R:L849	9.74	Yes	No	11	9	8
762	R:R:F854	R:R:Y858	29.91	No	No	0	4	8
763	S:S:G21	S:S:P22	4.06	No	No	0	3	5
764	S:S:G21	S:S:S113	3.71	No	No	0	3	4
765	S:S:F98	S:S:P22	8.67	Yes	No	0	4	5
766	S:S:D23	S:S:R25	8.34	No	No	0	1	4
767	S:S:Q27	S:S:R25	3.5	No	No	0	4	4
768	S:S:F98	S:S:R25	5.34	Yes	No	0	4	4
769	S:S:A26	S:S:I97	3.25	No	Yes	0	6	8
770	S:S:K29	S:S:Q27	5.42	No	No	0	3	4
771	S:S:Q27	S:S:R96	3.5	No	Yes	0	4	4
772	S:S:K28	S:S:N82	4.2	No	No	0	5	9
773	S:S:K28	S:S:Y95	13.14	No	Yes	0	5	8
774	S:S:H344	S:S:K28	6.55	No	No	0	3	5
775	S:S:K29	S:S:P136	3.35	No	No	0	3	4
776	S:S:D31	S:S:L91	6.79	No	No	0	8	6
777	S:S:I139	S:S:I32	4.42	No	No	0	5	6
778	S:S:I32	S:S:L431	4.28	No	No	0	6	8
779	S:S:I32	S:S:V455	3.07	No	No	0	6	4
780	S:S:I33	S:S:R96	5.01	No	Yes	0	5	4
781	S:S:I33	S:S:T138	3.04	No	No	0	5	6
782	S:S:I427	S:S:L34	4.28	No	No	0	5	7
783	S:S:F114	S:S:G35	3.01	Yes	No	0	5	8
784	S:S:L37	S:S:T100	5.9	No	No	0	6	7
785	S:S:F114	S:S:L37	3.65	Yes	No	0	5	6
786	S:S:L37	S:S:V153	2.98	No	No	0	6	6
787	S:S:F38	S:S:P39	4.33	Yes	Yes	2	7	6
788	S:S:F38	S:S:L71	6.09	Yes	No	2	7	4
789	S:S:F38	S:S:M74	7.46	Yes	No	2	7	8
790	S:S:F38	S:S:I97	3.77	Yes	Yes	2	7	8
791	S:S:F38	S:S:Y167	10.32	Yes	Yes	2	7	8
792	S:S:F38	S:S:V420	3.93	Yes	No	2	7	7
793	S:S:N64	S:S:P39	3.26	Yes	Yes	0	4	6
794	S:S:P39	S:S:W70	5.4	Yes	Yes	2	6	5
795	S:S:P39	S:S:T145	8.74	Yes	Yes	2	6	5
796	S:S:I40	S:S:Y63	3.63	Yes	Yes	2	5	5
797	S:S:I40	S:S:L71	4.28	Yes	No	2	5	4
798	S:S:D99	S:S:I40	9.8	Yes	Yes	2	9	5
799	S:S:F347	S:S:I40	3.77	Yes	Yes	2	5	5
800	S:S:C60	S:S:H41	8.85	No	Yes	2	7	7
801	S:S:H41	S:S:Y63	5.44	Yes	Yes	2	7	5
802	S:S:D99	S:S:H41	3.78	Yes	Yes	2	9	7
803	S:S:C101	S:S:H41	5.9	Yes	Yes	2	8	7
804	S:S:E350	S:S:H41	4.92	No	Yes	2	5	7
805	S:S:F42	S:S:R62	8.55	Yes	No	0	3	4
806	S:S:F42	S:S:N64	13.29	Yes	Yes	0	3	4
807	S:S:F42	S:S:P274	7.22	Yes	Yes	44	3	3
808	S:S:F42	S:S:L304	10.96	Yes	No	44	3	2
809	M:M:?1102	S:S:F42	4.47	No	Yes	0	0	3
810	S:S:V44	S:S:V58	6.41	No	No	0	2	1
811	S:S:T103	S:S:V44	6.35	No	No	0	4	2
812	S:S:K47	S:S:Q49	4.07	No	No	0	2	1
813	S:S:K47	S:S:V58	3.04	No	No	0	2	1
814	S:S:D50	S:S:K52	4.15	No	No	0	3	3
815	S:S:L51	S:S:P55	4.93	Yes	No	18	6	6
816	S:S:K106	S:S:S57	3.06	Yes	No	0	4	1
817	S:S:C101	S:S:C60	7.28	Yes	No	2	8	7
818	S:S:C60	S:S:K106	3.23	No	Yes	0	7	4
819	S:S:F65	S:S:Y63	10.32	Yes	Yes	2	2	5
820	S:S:F68	S:S:Y63	3.09	Yes	Yes	2	7	5
821	S:S:E350	S:S:Y63	4.49	No	Yes	2	5	5
822	S:S:F351	S:S:Y63	5.16	Yes	Yes	2	6	5
823	S:S:E354	S:S:Y63	4.49	No	Yes	0	4	5
824	S:S:N64	S:S:R66	3.62	Yes	Yes	0	4	5
825	S:S:G67	S:S:N64	5.09	No	Yes	0	4	4
826	S:S:F351	S:S:F65	4.29	Yes	Yes	2	6	2
827	S:S:F65	S:S:T355	5.19	Yes	Yes	2	2	4
828	S:S:F65	S:S:T406	9.08	Yes	No	2	2	4
829	S:S:F65	S:S:Y408	3.09	Yes	Yes	2	2	3
830	S:S:R66	S:S:R69	3.2	Yes	No	0	5	8
831	S:S:R66	S:S:W70	11	Yes	Yes	0	5	5
832	S:S:R66	X:X:W1101	3	Yes	Yes	0	5	0
833	S:S:G67	S:S:W70	5.63	No	Yes	0	4	5
834	S:S:F68	S:S:Q72	10.54	Yes	No	0	7	7
835	S:S:F351	S:S:F68	9.65	Yes	Yes	2	6	7
836	S:S:F68	S:S:Y408	6.19	Yes	Yes	2	7	3
837	S:S:F330	S:S:R69	3.21	Yes	No	0	8	8
838	S:S:R69	S:S:Y411	11.32	No	Yes	0	8	5
839	S:S:T145	S:S:W70	3.64	Yes	Yes	2	5	5
840	S:S:W70	S:S:Y167	4.82	Yes	Yes	2	5	8
841	S:S:I416	S:S:W70	11.74	No	Yes	0	4	5
842	S:S:F347	S:S:L71	3.65	Yes	No	2	5	4
843	S:S:F333	S:S:Q72	4.68	No	No	0	7	7
844	S:S:N345	S:S:Q72	3.96	No	No	0	8	7
845	S:S:A73	S:S:F330	4.16	No	Yes	15	7	8
846	S:S:A73	S:S:S417	3.42	No	No	15	7	6
847	S:S:I97	S:S:M74	8.75	Yes	No	2	8	8
848	S:S:M74	S:S:V142	4.56	No	No	0	8	7
849	S:S:I75	S:S:Y95	13.3	No	Yes	0	4	8
850	S:S:E80	S:S:F76	4.66	No	Yes	15	8	7
851	S:S:F76	S:S:I327	3.77	Yes	Yes	15	7	6
852	S:S:F330	S:S:F76	7.5	Yes	Yes	15	8	7
853	S:S:F333	S:S:F76	13.93	No	Yes	0	7	7
854	S:S:F76	S:S:Y421	4.13	Yes	Yes	15	7	8
855	S:S:A77	S:S:Y421	5.34	No	Yes	0	8	8
856	S:S:I78	S:S:Y95	7.25	No	Yes	0	6	8
857	S:S:I78	S:S:V424	3.07	No	No	0	6	8
858	S:S:E80	S:S:Y421	6.73	No	Yes	15	8	8
859	S:S:E80	S:S:Y425	5.61	No	No	15	8	8
860	S:S:I81	S:S:L93	5.71	No	No	0	9	9
861	S:S:I81	S:S:Y425	4.84	No	No	0	9	8
862	S:S:A428	S:S:I81	3.25	No	No	0	9	9
863	S:S:N82	S:S:T92	10.24	No	No	0	9	7
864	S:S:H429	S:S:L87	3.86	No	No	0	6	6
865	S:S:L87	S:S:Q432	7.99	No	No	0	6	7
866	S:S:L431	S:S:L88	4.15	No	No	0	8	9
867	S:S:P89	S:S:Y435	9.74	No	No	0	8	3
868	S:S:I452	S:S:L91	4.28	No	No	0	3	6
869	S:S:I97	S:S:Y95	8.46	Yes	Yes	0	8	8
870	S:S:F98	S:S:R96	5.34	Yes	Yes	0	4	4
871	S:S:I135	S:S:R96	3.76	No	Yes	0	4	4
872	S:S:A110	S:S:F98	5.55	No	Yes	0	5	4
873	S:S:F114	S:S:F98	7.5	Yes	Yes	0	5	4
874	S:S:C101	S:S:D99	4.67	Yes	Yes	2	8	9
875	S:S:D99	S:S:F347	3.58	Yes	Yes	2	9	5
876	S:S:A107	S:S:T100	3.36	No	No	0	7	7
877	S:S:K106	S:S:T103	3	Yes	No	0	4	4
878	S:S:L108	S:S:V104	2.98	No	Yes	0	4	4
879	S:S:A152	S:S:V104	5.09	No	Yes	0	5	4
880	S:S:K106	S:S:S105	3.06	Yes	No	0	4	4
881	S:S:F114	S:S:T111	3.89	Yes	No	0	5	7
882	S:S:T111	S:S:V153	7.93	No	No	43	7	6
883	S:S:L157	S:S:T111	4.42	Yes	No	43	7	7
884	S:S:F114	S:S:T138	6.49	Yes	No	0	5	6
885	S:S:F114	S:S:V141	6.55	Yes	No	0	5	7
886	S:S:F160	S:S:V115	13.11	Yes	No	0	7	5
887	S:S:I162	S:S:V115	3.07	Yes	No	0	6	5
888	S:S:F128	S:S:Q117	7.03	No	No	0	3	6
889	S:S:Q117	S:S:S137	5.78	No	No	0	6	4
890	S:S:F160	S:S:N118	4.83	Yes	No	0	7	4
891	S:S:I162	S:S:N118	5.66	Yes	No	0	6	4
892	S:S:D126	S:S:I120	4.2	No	No	0	3	3
893	S:S:D121	S:S:S122	5.89	No	No	0	3	3
894	S:S:D121	S:S:F160	7.17	No	Yes	0	3	7
895	S:S:D126	S:S:F128	10.75	No	No	0	3	3
896	S:S:F128	S:S:H134	37.33	No	No	0	3	4
897	S:S:E133	S:S:S132	8.62	No	No	0	5	4
898	S:S:E133	S:S:P136	4.72	No	No	0	5	4
899	S:S:I139	S:S:V460	4.61	No	No	0	5	7
900	S:S:A140	S:S:P163	3.74	No	Yes	0	6	8
901	S:S:A140	S:S:I427	4.87	No	No	0	6	5
902	S:S:L157	S:S:V141	4.47	Yes	No	0	7	7
903	S:S:G143	S:S:Y167	5.79	No	Yes	0	9	8
904	S:S:A144	S:S:V149	3.39	No	No	0	6	4
905	S:S:A144	S:S:S150	3.42	No	No	0	6	8
906	S:S:G146	S:S:T145	3.64	No	Yes	0	5	5
907	S:S:T145	S:S:Y167	4.99	Yes	Yes	2	5	8
908	S:S:A168	S:S:T145	3.36	No	Yes	2	5	5
909	S:S:T145	X:X:W1101	3.64	Yes	Yes	2	5	0
910	S:S:G146	S:S:V149	3.68	No	No	0	5	4
911	S:S:S147	S:S:S169	3.26	No	Yes	9	8	8
912	S:S:S147	S:S:S171	6.52	No	No	9	8	7
913	S:S:L174	S:S:S147	4.5	Yes	No	9	7	8
914	S:S:D217	S:S:G148	5.03	No	No	0	6	4
915	S:S:S150	S:S:S169	6.52	No	Yes	9	8	8
916	S:S:L174	S:S:S150	3	Yes	No	9	7	8
917	S:S:L174	S:S:T151	4.42	Yes	No	9	7	5
918	S:S:F180	S:S:T151	6.49	Yes	No	9	5	5
919	S:S:L157	S:S:V153	2.98	Yes	No	43	7	6
920	S:S:A154	S:S:Q164	3.03	No	No	0	7	8
921	S:S:A154	S:S:F180	4.16	No	Yes	0	7	5
922	S:S:N155	S:S:Q179	3.96	No	No	9	5	5
923	S:S:F180	S:S:N155	3.62	Yes	No	9	5	5
924	S:S:I162	S:S:L157	5.71	Yes	Yes	0	6	7
925	S:S:F160	S:S:L159	6.09	Yes	No	0	7	5
926	S:S:K181	S:S:Y161	9.55	No	Yes	0	7	4
927	S:S:I162	S:S:P163	3.39	Yes	Yes	0	6	8
928	S:S:A457	S:S:I162	3.25	No	Yes	0	4	6
929	S:S:L461	S:S:P163	6.57	No	Yes	0	7	8
930	S:S:L464	S:S:P163	3.28	No	Yes	0	7	8
931	S:S:F183	S:S:Q164	11.71	Yes	No	0	8	8
932	S:S:A423	S:S:V165	3.39	No	No	0	9	6
933	S:S:I427	S:S:V165	4.61	No	No	0	5	6
934	S:S:S166	S:S:S169	4.89	No	Yes	9	9	8
935	S:S:F183	S:S:S166	3.96	Yes	No	9	8	9
936	S:S:V420	S:S:Y167	7.57	No	Yes	2	7	8
937	S:S:A168	X:X:W1101	3.89	No	Yes	2	5	0
938	S:S:L174	S:S:S169	3	Yes	Yes	9	7	8
939	S:S:F183	S:S:S169	3.96	Yes	Yes	9	8	8
940	S:S:I187	S:S:S170	4.64	No	No	0	6	7
941	S:S:D190	S:S:S170	5.89	Yes	No	0	8	7
942	S:S:L174	S:S:S171	3	Yes	No	9	7	7
943	S:S:L173	S:S:R172	4.86	No	No	0	5	4
944	S:S:N189	S:S:R172	3.62	Yes	No	0	8	4
945	S:S:L173	S:S:P221	9.85	No	No	0	5	3
946	S:S:F180	S:S:L174	7.31	Yes	Yes	9	5	7
947	S:S:F183	S:S:L174	15.83	Yes	Yes	9	8	7
948	S:S:N189	S:S:S175	2.98	Yes	No	0	8	8
949	S:S:C482	S:S:S175	5.16	No	No	0	7	8
950	S:S:F180	S:S:Q179	8.2	Yes	No	9	5	5
951	S:S:L461	S:S:S182	4.5	No	No	0	7	7
952	S:S:F183	S:S:R185	8.55	Yes	No	0	8	9
953	S:S:L184	S:S:L464	5.54	No	No	0	6	7
954	S:S:F479	S:S:L184	6.09	No	No	0	8	6
955	S:S:N189	S:S:R185	6.03	Yes	No	0	8	9
956	S:S:D484	S:S:R185	3.57	No	No	0	8	9
957	S:S:N419	S:S:T186	5.85	No	No	0	7	8
958	S:S:I187	S:S:P188	3.39	No	No	0	6	8
959	S:S:P188	S:S:Y489	4.17	No	Yes	0	8	8
960	S:S:E191	S:S:N189	3.94	No	Yes	0	3	8
961	S:S:D190	S:S:Q193	10.44	Yes	Yes	23	8	9
962	S:S:D190	S:S:Y218	5.75	Yes	Yes	23	8	7
963	S:S:D190	S:S:F270	5.97	Yes	Yes	23	8	7
964	S:S:F270	S:S:Q193	4.68	Yes	Yes	23	7	9
965	S:S:Q193	S:S:S296	4.33	Yes	No	23	9	8
966	S:S:E297	S:S:Q193	5.1	No	Yes	0	8	9
967	S:S:Q193	S:S:Y489	5.64	Yes	Yes	0	9	8
968	S:S:A194	S:S:K225	3.21	No	No	0	7	3
969	S:S:E229	S:S:T195	12.7	No	No	0	5	4
970	S:S:A196	S:S:Y511	9.34	No	Yes	0	8	5
971	S:S:M197	S:S:V268	3.04	No	No	0	7	6
972	S:S:F320	S:S:M197	4.98	No	No	0	6	7
973	S:S:D199	S:S:R233	5.96	No	Yes	0	7	4
974	S:S:D199	S:S:Y511	3.45	No	Yes	0	7	5
975	S:S:I200	S:S:L521	4.28	No	No	7	8	5
976	S:S:I200	S:S:I523	4.42	No	Yes	7	8	6
977	S:S:I201	S:S:W206	4.7	Yes	Yes	7	6	9
978	S:S:I201	S:S:V209	4.61	Yes	Yes	7	6	8
979	S:S:I201	S:S:I235	4.42	Yes	Yes	7	6	7
980	S:S:I201	S:S:V266	3.07	Yes	Yes	7	6	7
981	S:S:E202	S:S:R233	8.14	No	Yes	0	5	4
982	S:S:F204	S:S:Y203	8.25	Yes	No	7	7	5
983	S:S:L521	S:S:Y203	3.52	No	No	7	5	5
984	S:S:I523	S:S:Y203	10.88	Yes	No	7	6	5
985	S:S:F204	S:S:W206	11.02	Yes	Yes	7	7	9
986	S:S:F204	S:S:I523	5.02	Yes	Yes	7	7	6
987	S:S:E525	S:S:F204	5.83	No	Yes	0	4	7
988	S:S:F204	S:S:W530	10.02	Yes	Yes	7	7	8
989	H:H:?8	S:S:R205	4.33	Yes	No	8	0	4
990	H:H:?9	S:S:R205	5.42	No	No	8	0	4
991	S:S:V266	S:S:W206	15.94	Yes	Yes	7	7	9
992	S:S:I292	S:S:W206	3.52	No	Yes	7	7	9
993	S:S:W206	S:S:W530	3.75	Yes	Yes	7	9	8
994	S:S:S540	S:S:W206	11.12	No	Yes	7	9	9
995	S:S:C236	S:S:N207	3.15	No	Yes	8	9	6
996	S:S:N207	S:S:N541	10.9	Yes	No	8	6	5
997	S:S:C561	S:S:N207	4.72	No	Yes	8	9	6
998	H:H:?8	S:S:N207	15.92	Yes	Yes	8	0	6
999	S:S:C236	S:S:W208	5.22	No	Yes	8	9	9
1000	S:S:D238	S:S:W208	13.4	No	Yes	8	8	9
1001	S:S:A264	S:S:W208	3.89	No	Yes	0	7	9
1002	S:S:C542	S:S:W208	18.28	No	Yes	8	9	9
1003	S:S:P559	S:S:W208	5.4	No	Yes	0	6	9
1004	S:S:C562	S:S:W208	6.53	Yes	Yes	8	9	9
1005	S:S:G210	S:S:V209	3.68	No	Yes	0	8	8
1006	S:S:I235	S:S:V209	3.07	Yes	Yes	7	7	8
1007	S:S:V209	S:S:V266	6.41	Yes	Yes	7	8	7
1008	S:S:F239	S:S:G210	9.03	Yes	No	0	6	8
1009	S:S:I223	S:S:T211	7.6	No	No	0	5	5
1010	S:S:I237	S:S:T211	3.04	No	No	0	6	5
1011	S:S:S240	S:S:T211	3.2	No	No	0	4	5
1012	S:S:I212	S:S:I243	4.42	No	No	0	6	5
1013	S:S:A213	S:S:I223	4.87	No	No	0	4	5
1014	S:S:A214	S:S:S271	3.42	No	No	0	5	4
1015	S:S:A214	S:S:D275	4.63	No	No	0	5	5
1016	S:S:D215	S:S:R220	8.34	No	No	0	6	6
1017	S:S:D215	S:S:L242	6.79	No	No	0	6	4
1018	S:S:D216	S:S:Y218	3.45	No	Yes	0	6	7
1019	S:S:G219	S:S:Y218	4.35	No	Yes	0	7	7
1020	S:S:F270	S:S:Y218	9.28	Yes	Yes	23	7	7
1021	S:S:S296	S:S:Y218	7.63	No	Yes	23	8	7
1022	S:S:A298	S:S:Y218	4	No	Yes	0	6	7
1023	S:S:F270	S:S:G222	4.52	Yes	No	0	7	7
1024	S:S:F270	S:S:I223	3.77	Yes	No	0	7	5
1025	S:S:E224	S:S:R227	11.63	No	Yes	0	6	4
1026	S:S:E229	S:S:K225	16.2	No	No	0	5	3
1027	S:S:A230	S:S:F226	5.55	No	No	0	6	6
1028	S:S:F226	S:S:V268	5.24	No	No	0	6	6
1029	S:S:I237	S:S:R227	11.27	No	Yes	0	6	4
1030	S:S:R227	S:S:S240	7.91	Yes	No	0	4	4
1031	S:S:A230	S:S:I235	6.5	No	Yes	0	6	7
1032	S:S:I235	S:S:R233	3.76	Yes	Yes	0	7	4
1033	S:S:K517	S:S:R233	3.71	No	Yes	0	1	4
1034	S:S:D234	X:X:?1108	7.48	No	No	39	5	0
1035	S:S:C236	S:S:C561	7.28	No	No	8	9	9
1036	S:S:D238	S:S:F239	9.55	No	Yes	8	8	6
1037	S:S:D238	S:S:S262	8.83	No	No	8	8	7
1038	S:S:F239	S:S:V258	3.93	Yes	No	0	6	4
1039	S:S:F239	S:S:S262	5.28	Yes	No	8	6	7
1040	S:S:E241	S:S:H254	6.15	No	No	0	5	3
1041	S:S:E241	S:S:V255	5.7	No	Yes	0	5	5
1042	S:S:I243	S:S:V255	3.07	No	Yes	0	5	5
1043	S:S:Q245	S:S:Y246	16.91	No	No	0	4	3
1044	S:S:D275	S:S:Q245	6.53	No	No	0	5	4
1045	S:S:I252	S:S:S247	4.64	No	No	0	4	2
1046	S:S:D248	S:S:E250	3.9	No	No	0	3	2
1047	S:S:D248	S:S:E251	3.9	No	No	0	3	4
1048	S:S:E249	S:S:Q253	5.1	No	No	0	2	3
1049	S:S:E257	S:S:Q253	6.37	No	No	0	3	3
1050	S:S:Q253	S:S:R286	7.01	No	Yes	0	3	4
1051	S:S:H254	S:S:V258	4.15	No	No	0	3	4
1052	S:S:L279	S:S:V255	4.47	No	Yes	0	5	5
1053	S:S:E282	S:S:V256	12.84	No	No	29	6	5
1054	S:S:I283	S:S:V256	3.07	Yes	No	0	4	5
1055	S:S:R286	S:S:V256	6.54	Yes	No	29	4	5
1056	S:S:Q260	S:S:R286	8.18	No	Yes	0	5	4
1057	S:S:I288	S:S:Q260	9.61	No	No	0	4	5
1058	H:H:?15	S:S:N261	30.62	No	No	0	0	4
1059	S:S:K265	S:S:S540	3.06	No	No	0	5	9
1060	S:S:I292	S:S:V266	3.07	No	Yes	7	7	7
1061	S:S:L294	S:S:V266	4.47	No	Yes	0	7	7
1062	S:S:S540	S:S:V266	4.85	No	Yes	7	9	7
1063	S:S:I267	S:S:K291	5.82	No	No	0	7	6
1064	S:S:I267	S:S:W293	8.22	No	No	0	7	8
1065	S:S:L294	S:S:V268	4.47	No	No	0	7	6
1066	S:S:L276	S:S:V269	4.47	No	No	16	5	5
1067	S:S:V269	S:S:W299	9.81	No	Yes	16	5	7
1068	S:S:F270	S:S:S296	6.61	Yes	No	23	7	8
1069	S:S:G273	S:S:S272	3.71	No	No	0	4	5
1070	S:S:G273	S:S:P274	4.06	No	Yes	0	4	3
1071	S:S:L304	S:S:P274	3.28	No	Yes	44	2	3
1072	S:S:I280	S:S:L276	7.14	Yes	No	0	5	5
1073	S:S:L276	S:S:W299	10.25	No	Yes	16	5	7
1074	S:S:E277	S:S:P278	3.14	No	No	0	2	2
1075	S:S:E277	S:S:K281	10.8	No	No	0	2	2
1076	S:S:E277	S:S:L304	5.3	No	No	0	2	2
1077	S:S:I283	S:S:L279	4.28	Yes	No	0	4	5
1078	S:S:I280	S:S:I305	7.36	Yes	No	0	5	4
1079	S:S:I280	S:S:Y310	3.63	Yes	Yes	0	5	3
1080	S:S:I280	S:S:V314	3.07	Yes	No	0	5	7
1081	S:S:E282	S:S:R285	4.65	No	No	29	6	3
1082	S:S:E282	S:S:R286	12.79	No	Yes	29	6	4
1083	S:S:I283	S:S:W293	3.52	Yes	No	0	4	8
1084	S:S:I283	S:S:V313	4.61	Yes	No	0	4	3
1085	S:S:V284	S:S:Y310	8.83	No	Yes	0	3	3
1086	S:S:R285	S:S:R286	5.33	No	Yes	29	3	4
1087	H:H:?16	S:S:N287	29.4	No	No	0	0	6
1088	S:S:G290	S:S:T289	3.64	No	No	0	4	5
1089	S:S:I292	S:S:W530	3.52	No	Yes	7	7	8
1090	S:S:T317	S:S:W293	3.64	No	No	0	7	8
1091	S:S:A295	S:S:W299	6.48	No	Yes	0	7	7
1092	S:S:E297	S:S:L322	13.25	No	No	0	8	4
1093	S:S:E297	X:X:W1101	6.54	No	Yes	0	8	0
1094	S:S:A298	X:X:W1101	6.48	No	Yes	0	6	0
1095	S:S:I305	S:S:W299	5.87	No	Yes	16	4	7
1096	S:S:W299	S:S:W494	3.75	Yes	Yes	16	7	7
1097	M:M:?1102	S:S:S302	5.51	No	No	0	0	5
1098	S:S:P407	S:S:S303	3.56	No	No	0	1	3
1099	S:S:I305	S:S:W494	3.52	No	Yes	16	4	7
1100	S:S:A306	S:S:W494	5.19	No	Yes	16	4	7
1101	S:S:A306	S:S:I503	4.87	No	Yes	16	4	4
1102	S:S:M307	S:S:P308	3.35	No	No	0	3	2
1103	S:S:M307	S:S:Q309	5.44	No	No	45	3	3
1104	S:S:M307	S:S:Y310	7.18	No	Yes	45	3	3
1105	S:S:Q309	S:S:Y310	4.51	No	Yes	45	3	3
1106	S:S:F311	S:S:G315	4.52	No	No	0	3	4
1107	S:S:F311	S:S:L496	7.31	No	No	0	3	3
1108	S:S:F311	S:S:I503	5.02	No	Yes	0	3	4
1109	S:S:V314	S:S:W494	3.68	No	Yes	0	7	7
1110	S:S:G316	S:S:N493	3.39	No	No	0	8	9
1111	S:S:T317	S:S:W494	18.19	No	Yes	0	7	7
1112	S:S:F320	S:S:Y489	3.09	No	Yes	0	6	8
1113	S:S:F320	S:S:I491	6.28	No	No	0	6	8
1114	S:S:A321	S:S:R415	6.91	No	No	0	5	5
1115	S:S:A324	S:S:H413	4.39	No	No	0	5	7
1116	S:S:G325	S:S:Y418	7.24	No	Yes	0	4	7
1117	S:S:I327	S:S:P328	3.39	Yes	No	0	6	4
1118	S:S:F330	S:S:I327	6.28	Yes	Yes	15	8	6
1119	S:S:I327	S:S:L414	4.28	Yes	Yes	15	6	6
1120	S:S:I327	S:S:Y421	9.67	Yes	Yes	15	6	8
1121	S:S:F330	S:S:L334	10.96	Yes	No	0	8	6
1122	S:S:F330	S:S:L414	4.87	Yes	Yes	15	8	6
1123	S:S:F330	S:S:S417	3.96	Yes	No	15	8	6
1124	S:S:K335	S:S:R331	3.71	No	No	0	4	4
1125	S:S:R331	S:S:Y411	15.43	No	Yes	0	4	5
1126	S:S:L334	S:S:Y408	9.38	No	Yes	0	6	3
1127	S:S:L334	S:S:Y411	3.52	No	Yes	0	6	5
1128	S:S:I409	S:S:K335	5.82	No	No	0	5	4
1129	S:S:H338	S:S:P339	10.68	No	Yes	0	4	7
1130	S:S:H338	S:S:R340	3.39	No	No	0	4	4
1131	S:S:H338	S:S:K341	20.96	No	No	0	4	3
1132	S:S:P339	S:S:W352	25.67	Yes	Yes	0	7	8
1133	S:S:L360	S:S:P339	3.28	No	Yes	0	4	7
1134	S:S:N345	S:S:S342	2.98	No	No	0	8	3
1135	S:S:H344	S:S:V343	6.92	No	No	0	3	3
1136	S:S:F347	S:S:N345	3.62	Yes	No	0	5	8
1137	S:S:F351	S:S:T355	9.08	Yes	Yes	2	6	4
1138	S:S:F351	S:S:Y408	11.35	Yes	Yes	2	6	3
1139	S:S:F356	S:S:W352	17.04	Yes	Yes	2	8	8
1140	S:S:G397	S:S:W352	4.22	No	Yes	2	5	8
1141	S:S:E399	S:S:W352	6.54	Yes	Yes	2	8	8
1142	S:S:F356	S:S:T355	9.08	Yes	Yes	2	8	4
1143	S:S:T355	S:S:T406	3.14	Yes	No	2	4	4
1144	S:S:E399	S:S:F356	16.32	Yes	Yes	2	8	8
1145	S:S:C358	S:S:C395	7.28	No	No	0	9	9
1146	S:S:E362	S:S:L360	5.3	No	No	0	1	4
1147	S:S:L394	S:S:Q361	9.32	No	No	0	1	1
1148	S:S:C395	S:S:E399	4.56	No	Yes	0	9	8
1149	S:S:E399	S:S:T396	4.23	Yes	No	0	8	6
1150	S:S:D398	S:S:G397	3.35	No	No	0	3	5
1151	S:S:E399	S:S:G397	3.27	Yes	No	2	8	5
1152	S:S:N400	S:S:S402	7.45	No	No	0	4	4
1153	S:S:N400	S:S:S403	4.47	No	No	0	4	2
1154	S:S:S403	S:S:V404	3.23	No	No	0	2	4
1155	S:S:D410	S:S:E405	6.5	No	No	0	6	4
1156	S:S:P407	S:S:T406	3.5	No	No	0	1	4
1157	S:S:L414	S:S:Y411	7.03	Yes	Yes	0	6	5
1158	S:S:H413	S:S:T412	6.85	No	No	0	7	5
1159	S:S:H413	S:S:R415	9.03	No	No	0	7	5
1160	S:S:L414	S:S:S417	4.5	Yes	No	15	6	6
1161	S:S:I416	X:X:W1101	3.52	No	Yes	0	4	0
1162	S:S:L422	S:S:Y418	5.86	No	Yes	24	8	7
1163	S:S:N471	S:S:Y418	4.65	Yes	Yes	24	6	7
1164	S:S:N472	S:S:Y418	3.49	No	Yes	24	4	7
1165	S:S:M473	S:S:Y418	4.79	No	Yes	24	4	7
1166	S:S:Y421	S:S:Y425	13.9	Yes	No	15	8	8
1167	S:S:L422	S:S:N471	4.12	No	Yes	24	8	6
1168	S:S:L467	S:S:S426	3	No	No	0	7	7
1169	S:S:F479	S:S:S426	5.28	No	No	0	8	7
1170	S:S:F469	S:S:H429	21.5	No	No	0	8	6
1171	S:S:A430	S:S:L464	3.15	No	No	0	8	7
1172	S:S:Q432	S:S:T436	4.25	No	No	0	7	4
1173	S:S:I434	S:S:I452	4.42	No	No	0	6	3
1174	S:S:I434	S:S:V455	3.07	No	No	0	6	4
1175	S:S:H463	S:S:I434	13.26	No	No	0	5	6
1176	S:S:T436	S:S:Y435	4.99	No	No	0	4	3
1177	S:S:I452	S:S:Y435	3.63	No	No	0	3	3
1178	S:S:C437	S:S:C449	7.28	No	No	0	6	7
1179	S:S:L438	S:S:P439	3.28	No	No	0	3	2
1180	S:S:C449	S:S:G442	3.92	No	No	0	7	4
1181	S:S:H463	S:S:L443	5.14	No	No	0	5	3
1182	S:S:H466	S:S:L443	6.43	No	No	0	4	3
1183	S:S:F444	S:S:Q459	9.37	Yes	Yes	0	3	7
1184	S:S:F444	S:S:K462	3.72	Yes	No	0	3	4
1185	S:S:F444	S:S:H463	5.66	Yes	No	0	3	5
1186	H:H:?17	S:S:N446	35.52	No	No	0	0	3
1187	S:S:A450	S:S:Q459	4.55	No	Yes	0	3	7
1188	S:S:D451	S:S:K454	4.15	No	No	0	3	3
1189	S:S:E456	S:S:W458	14.17	No	Yes	17	5	4
1190	S:S:E456	S:S:Q459	6.37	No	Yes	17	5	7
1191	S:S:Q459	S:S:W458	12.05	Yes	Yes	17	7	4
1192	S:S:H466	S:S:K462	9.17	No	No	0	4	4
1193	S:S:F469	S:S:L467	3.65	No	No	0	8	7
1194	S:S:N468	S:S:Q476	3.96	No	No	0	6	3
1195	H:H:?18	S:S:N468	26.95	No	No	0	0	6
1196	S:S:F469	S:S:V477	9.18	No	No	0	8	6
1197	S:S:Q476	S:S:T470	9.92	No	No	0	3	5
1198	S:S:E475	S:S:N471	3.94	No	Yes	0	5	6
1199	S:S:N471	S:S:V477	5.91	Yes	No	0	6	6
1200	S:S:M473	S:S:N472	5.61	No	No	24	4	4
1201	S:S:L485	S:S:V477	5.96	No	No	0	4	6
1202	H:H:?18	S:S:T478	3.94	No	No	0	0	3
1203	S:S:F479	S:S:L485	6.09	No	No	0	8	4
1204	S:S:D480	S:S:D484	3.99	No	No	0	7	8
1205	S:S:V486	S:S:Y514	3.79	No	Yes	0	3	4
1206	S:S:N488	S:S:N512	5.45	Yes	Yes	25	4	4
1207	S:S:N488	S:S:V513	5.91	Yes	No	0	4	3
1208	S:S:N488	S:S:Y514	6.98	Yes	Yes	25	4	4
1209	H:H:?6	S:S:N488	28.17	Yes	Yes	25	0	4
1210	S:S:Y489	S:S:Y511	2.98	Yes	Yes	0	8	5
1211	S:S:E507	S:S:S490	8.62	No	No	0	5	8
1212	S:S:I491	S:S:V508	3.07	No	No	0	8	7
1213	S:S:I492	S:S:W494	3.52	No	Yes	16	5	7
1214	S:S:F505	S:S:I492	6.28	No	No	16	4	5
1215	S:S:H495	S:S:N493	7.65	Yes	No	0	7	9
1216	S:S:I528	S:S:N493	5.66	No	No	0	7	9
1217	S:S:I503	S:S:W494	3.52	Yes	Yes	16	4	7
1218	S:S:F505	S:S:W494	11.02	No	Yes	16	4	7
1219	S:S:H495	S:S:K506	6.55	Yes	No	0	7	5
1220	S:S:H495	S:S:L529	11.57	Yes	No	0	7	4
1221	S:S:P498	S:S:S497	3.56	No	Yes	46	3	3
1222	S:S:E499	S:S:S497	5.75	No	Yes	46	4	3
1223	S:S:G501	S:S:S497	3.71	No	Yes	0	5	3
1224	S:S:S497	S:S:V504	3.23	Yes	No	0	3	3
1225	S:S:E499	S:S:P498	3.14	No	No	46	4	3
1226	S:S:F505	S:S:I503	3.77	No	Yes	16	4	4
1227	S:S:K527	S:S:V508	3.04	No	No	0	3	7
1228	S:S:I528	S:S:V508	6.14	No	No	0	7	7
1229	S:S:F522	S:S:Y510	14.44	No	No	0	1	3
1230	H:H:?6	S:S:Y510	13.59	Yes	No	0	0	3
1231	S:S:R520	S:S:Y511	7.2	No	Yes	0	3	5
1232	S:S:N512	S:S:Y514	3.49	Yes	Yes	25	4	4
1233	S:S:A515	S:S:N512	3.13	No	Yes	0	4	4
1234	H:H:?6	S:S:N512	18.37	Yes	Yes	25	0	4
1235	H:H:?7	S:S:N512	3.67	No	Yes	25	0	4
1236	H:H:?6	S:S:Y514	11.5	Yes	Yes	25	0	4
1237	S:S:E519	S:S:K516	6.75	No	No	0	4	2
1238	S:S:I523	S:S:L521	8.56	Yes	No	7	6	5
1239	S:S:E526	S:S:N524	5.26	No	No	0	3	5
1240	S:S:K527	S:S:N524	6.99	No	No	0	3	5
1241	S:S:I528	S:S:W530	14.09	No	Yes	0	7	8
1242	S:S:L529	S:S:R535	3.64	No	No	0	4	4
1243	S:S:V537	S:S:W530	4.9	No	Yes	7	4	8
1244	S:S:P538	S:S:W530	14.86	No	Yes	7	8	8
1245	S:S:E536	S:S:S534	4.31	No	No	0	5	4
1246	S:S:P538	S:S:V537	3.53	No	No	7	8	4
1247	S:S:F539	S:S:N541	7.25	No	No	8	1	5
1248	S:S:F539	S:S:R544	27.79	No	No	0	1	5
1249	H:H:?8	S:S:F539	4.35	Yes	No	8	0	1
1250	H:H:?8	S:S:N541	25.72	Yes	No	8	0	5
1251	S:S:C542	S:S:C562	7.28	No	Yes	8	9	9
1252	S:S:D545	S:S:D578	10.65	No	No	0	5	7
1253	S:S:C546	S:S:T550	6.76	No	No	47	9	6
1254	S:S:C546	S:S:C565	7.28	No	No	47	9	9
1255	S:S:C565	S:S:T550	3.38	No	No	47	9	6
1256	S:S:R551	S:S:V566	7.85	No	No	0	7	4
1257	S:S:F563	S:S:K552	16.13	No	No	0	7	8
1258	S:S:K552	S:S:S580	3.06	No	No	38	8	4
1259	S:S:E558	S:S:I555	9.56	No	No	0	5	5
1260	S:S:G557	W:W:?1103	3.14	No	No	33	6	0
1261	S:S:E558	S:S:P559	3.14	No	No	0	5	6
1262	S:S:C562	S:S:E558	3.04	Yes	No	0	9	5
1263	S:S:E564	S:S:V566	4.28	No	No	0	6	4
1264	S:S:E567	S:S:H595	8.62	No	No	0	4	5
1265	S:S:C568	S:S:E572	13.67	Yes	Yes	30	9	7
1266	S:S:C568	S:S:C582	7.28	Yes	No	30	9	9
1267	S:S:D570	S:S:P569	9.66	No	No	0	5	5
1268	S:S:C585	S:S:G571	3.92	Yes	No	0	9	7
1269	S:S:G571	S:S:S591	3.71	No	No	0	7	8
1270	S:S:E572	S:S:S574	10.06	Yes	No	30	7	8
1271	S:S:C582	S:S:E572	13.67	No	Yes	30	9	7
1272	S:S:E572	S:S:H595	3.69	Yes	No	0	7	5
1273	S:S:D575	S:S:Y573	8.05	No	Yes	0	8	6
1274	S:S:N583	S:S:Y573	31.4	No	Yes	0	1	6
1275	S:S:C585	S:S:Y573	8.06	Yes	Yes	48	9	6
1276	S:S:C598	S:S:Y573	6.72	No	Yes	48	9	6
1277	S:S:C582	S:S:S574	5.16	No	No	30	9	8
1278	S:S:D575	S:S:E576	3.9	No	No	0	8	3
1279	S:S:D575	S:S:S597	7.36	No	No	0	8	1
1280	S:S:A579	S:S:E576	4.53	No	No	0	7	3
1281	S:S:D578	S:S:T577	4.34	No	No	0	7	5
1282	S:S:C585	S:S:C598	7.28	Yes	No	48	9	9
1283	S:S:F589	S:S:P586	7.22	No	No	0	5	4
1284	S:S:D588	S:S:E602	5.2	No	No	49	6	3
1285	S:S:D588	S:S:I761	5.6	No	No	49	6	7
1286	S:S:E757	S:S:W590	4.36	No	No	0	4	6
1287	S:S:D758	S:S:W590	15.63	No	No	0	4	6
1288	S:S:H595	S:S:S591	4.18	No	No	0	5	8
1289	S:S:N592	S:S:N594	4.09	No	No	0	7	3
1290	S:S:N594	S:S:T596	4.39	No	No	0	3	5
1291	S:S:E604	S:S:K601	9.45	No	No	0	6	8
1292	S:S:E602	S:S:Q754	3.82	No	No	0	3	4
1293	S:S:E602	S:S:I761	13.66	No	No	49	3	7
1294	S:S:F605	S:S:I603	33.91	No	No	0	7	4
1295	S:S:E759	S:S:I603	5.47	No	No	0	4	4
1296	S:S:F605	S:S:F762	8.57	No	Yes	0	7	7
1297	S:S:E671	S:S:L606	15.9	No	No	0	4	9
1298	S:S:K831	S:S:S607	7.65	No	No	0	9	7
1299	S:S:T609	S:S:W608	9.7	No	No	0	4	5
1300	S:S:G670	S:S:W608	4.22	No	No	0	7	5
1301	S:S:E671	S:S:W608	3.27	No	No	0	4	5
1302	S:S:E610	S:S:P611	6.29	No	No	0	7	4
1303	S:S:I614	S:S:T617	6.08	No	No	0	6	5
1304	S:S:I839	S:S:L616	5.71	No	No	0	7	8
1305	S:S:I669	S:S:T617	4.56	No	No	0	8	5
1306	S:S:F619	S:S:L842	9.74	No	Yes	0	3	9
1307	S:S:A620	S:S:L842	4.73	No	Yes	0	7	9
1308	S:S:F662	S:S:G623	9.03	Yes	No	0	8	6
1309	S:S:I624	S:S:T627	3.04	No	No	0	5	7
1310	S:S:I624	S:S:S663	3.1	No	No	0	5	6
1311	S:S:F625	S:S:F629	34.29	No	No	0	3	3
1312	S:S:L659	S:S:T627	5.9	No	No	0	4	7
1313	S:S:V630	S:S:V633	3.21	Yes	No	12	7	5
1314	S:S:F634	S:S:V630	9.18	Yes	Yes	12	9	7
1315	S:S:F853	S:S:V630	11.8	Yes	Yes	12	9	7
1316	S:S:I857	S:S:V630	6.14	Yes	Yes	12	8	7
1317	S:S:I635	S:S:L631	7.14	No	No	0	4	4
1318	S:S:L631	S:S:L655	5.54	No	Yes	0	4	9
1319	S:S:G632	S:S:I635	3.53	No	No	0	1	4
1320	S:S:I857	S:S:V633	6.14	Yes	No	12	8	5
1321	S:S:F634	S:S:L655	3.65	Yes	Yes	12	9	9
1322	S:S:F634	S:S:F853	16.08	Yes	Yes	12	9	9
1323	S:S:F634	S:S:I857	13.82	Yes	Yes	12	9	8
1324	S:S:E649	S:S:F725	27.98	No	No	4	7	5
1325	S:S:E649	S:S:L726	11.93	No	No	4	7	4
1326	S:S:L650	S:S:V697	2.98	No	No	0	8	8
1327	S:S:L653	S:S:Y652	5.86	No	No	0	5	7
1328	S:S:L654	S:S:S693	10.51	No	No	0	8	9
1329	S:S:F853	S:S:L655	6.09	Yes	Yes	12	9	9
1330	S:S:C660	S:S:F656	5.59	No	No	0	7	4
1331	S:S:S657	S:S:V689	6.46	No	No	0	9	7
1332	S:S:L690	S:S:S657	3	Yes	No	0	7	9
1333	S:S:L658	S:S:L690	4.15	No	Yes	12	8	7
1334	S:S:L658	S:S:L849	17.99	No	No	12	8	8
1335	S:S:F853	S:S:L658	4.87	Yes	No	12	9	8
1336	S:S:C660	S:S:I686	6.55	No	Yes	0	7	7
1337	S:S:C661	S:S:I686	6.55	No	Yes	0	7	7
1338	S:S:C661	S:S:S687	5.16	No	No	12	7	6
1339	S:S:C661	S:S:L690	9.52	No	Yes	12	7	7
1340	S:S:F662	S:S:L842	3.65	Yes	Yes	0	8	9
1341	S:S:F662	S:S:S845	7.93	Yes	No	0	8	8
1342	S:S:I686	S:S:S664	3.1	Yes	No	0	7	6
1343	S:S:I841	S:S:S665	3.1	No	No	0	9	8
1344	S:S:L842	S:S:S665	4.5	Yes	No	0	9	8
1345	S:S:F667	S:S:L666	14.61	No	No	0	5	7
1346	S:S:F668	S:S:R680	13.9	Yes	No	0	9	8
1347	S:S:F668	S:S:S834	5.28	Yes	No	0	9	8
1348	S:S:E837	S:S:F668	7	No	Yes	0	9	9
1349	S:S:F668	S:S:V838	5.24	Yes	No	0	9	7
1350	S:S:P672	S:S:S750	5.34	Yes	No	26	9	6
1351	S:S:I763	S:S:P672	8.47	No	Yes	0	7	9
1352	S:S:C765	S:S:P672	3.77	Yes	Yes	26	9	9
1353	S:S:T676	S:S:W675	8.49	No	No	0	7	3
1354	S:S:C677	S:S:R680	4.18	No	No	26	9	8
1355	S:S:C677	S:S:S750	5.16	No	No	26	9	6
1356	S:S:C677	S:S:C765	7.28	No	Yes	26	9	9
1357	S:S:Q681	S:S:R678	17.52	No	No	4	9	5
1358	S:S:L743	S:S:R678	23.08	No	No	4	7	5
1359	S:S:P748	S:S:R678	10.09	No	No	0	9	5
1360	S:S:L679	S:S:P682	9.85	No	No	0	5	5
1361	S:S:C765	S:S:R680	9.75	Yes	No	26	9	8
1362	S:S:C739	S:S:Q681	7.63	No	No	4	7	9
1363	S:S:L743	S:S:Q681	11.98	No	No	4	7	9
1364	S:S:F684	S:S:F775	6.43	Yes	Yes	4	8	4
1365	S:S:F684	S:S:L776	26.79	Yes	No	4	8	8
1366	S:S:F684	S:S:Y779	25.79	Yes	Yes	4	8	9
1367	S:S:F684	S:S:W818	3.01	Yes	Yes	0	8	9
1368	S:S:F775	S:S:G685	3.01	Yes	No	0	4	8
1369	S:S:L690	S:S:S687	4.5	Yes	No	12	7	6
1370	S:S:C731	S:S:F688	13.97	No	Yes	4	5	8
1371	S:S:F688	S:S:Q735	9.37	Yes	Yes	4	8	9
1372	S:S:F688	S:S:Y779	7.22	Yes	Yes	4	8	9
1373	S:S:F688	S:S:L783	13.4	Yes	No	4	8	9
1374	S:S:T732	S:S:V689	9.52	No	No	0	7	7
1375	S:S:C691	S:S:L783	4.76	No	No	0	8	9
1376	S:S:I692	S:S:I695	5.89	Yes	No	0	7	7
1377	S:S:I692	S:S:L696	12.85	Yes	No	4	7	8
1378	S:S:I692	S:S:V728	10.75	Yes	No	4	7	7
1379	S:S:C694	S:S:C787	7.28	No	No	0	6	8
1380	S:S:L696	S:S:V728	4.47	No	No	4	8	7
1381	S:S:I807	S:S:V697	3.07	Yes	No	0	9	8
1382	S:S:I807	S:S:K698	13.09	Yes	No	0	9	9
1383	S:S:L727	S:S:Q724	6.65	No	No	0	7	8
1384	S:S:F725	S:S:L726	15.83	No	No	4	5	4
1385	S:S:L727	S:S:L730	4.15	No	No	0	7	3
1386	S:S:C731	S:S:L783	3.17	No	No	4	5	9
1387	S:S:I736	S:S:T732	3.04	No	No	0	5	7
1388	S:S:F733	S:S:V737	6.55	No	No	0	4	3
1389	S:S:I738	S:S:Q735	6.86	No	Yes	4	8	9
1390	S:S:C739	S:S:Q735	4.58	No	Yes	4	7	9
1391	S:S:F775	S:S:Q735	35.14	Yes	Yes	4	4	9
1392	S:S:Q735	S:S:Y779	12.4	Yes	Yes	4	9	9
1393	S:S:I741	S:S:V737	3.07	No	No	0	4	3
1394	S:S:I738	S:S:W742	8.22	No	Yes	4	8	9
1395	S:S:F775	S:S:I738	7.54	Yes	No	4	4	8
1396	S:S:C739	S:S:F775	8.38	No	Yes	4	7	4
1397	S:S:I741	S:S:W742	8.22	No	Yes	0	4	9
1398	S:S:T745	S:S:W742	9.7	No	Yes	4	4	9
1399	S:S:M771	S:S:W742	27.92	Yes	Yes	4	3	9
1400	S:S:M771	S:S:T745	10.54	Yes	No	4	3	4
1401	S:S:A746	S:S:M771	3.22	No	Yes	0	6	3
1402	S:S:C765	S:S:S750	5.16	Yes	No	26	9	6
1403	S:S:N753	S:S:Y751	5.81	Yes	No	0	7	3
1404	S:S:H766	S:S:Y751	4.36	No	No	0	6	3
1405	S:S:E755	S:S:N753	3.94	No	Yes	50	4	7
1406	S:S:F762	S:S:N753	3.62	Yes	Yes	50	7	7
1407	S:S:N753	S:S:T764	11.7	Yes	No	0	7	7
1408	S:S:I760	S:S:Q754	6.86	No	No	0	5	4
1409	S:S:E755	S:S:F762	7	No	Yes	50	4	7
1410	S:S:E755	S:S:Y829	3.37	No	No	0	4	6
1411	S:S:I760	S:S:L756	8.56	No	No	0	5	5
1412	S:S:D758	S:S:E759	6.5	No	No	0	4	4
1413	S:S:F762	S:S:I760	10.05	Yes	No	0	7	5
1414	S:S:E767	S:S:Y825	4.49	No	Yes	0	7	9
1415	S:S:L770	S:S:M771	7.07	No	Yes	0	3	3
1416	S:S:I777	S:S:L773	7.14	No	No	0	8	8
1417	S:S:F775	S:S:Y779	17.54	Yes	Yes	4	4	9
1418	S:S:L776	S:S:Y779	16.41	No	Yes	4	8	9
1419	S:S:L776	S:S:T780	4.42	No	No	4	8	7
1420	S:S:T780	S:S:Y779	23.72	No	Yes	4	7	9
1421	S:S:T780	S:S:W818	7.28	No	Yes	0	7	9
1422	S:S:I786	S:S:L782	7.14	No	No	0	4	4
1423	S:S:F790	S:S:I786	3.77	No	No	0	7	4
1424	S:S:C787	S:S:M811	8.1	No	No	0	8	9
1425	S:S:F792	S:S:K796	4.96	No	No	0	8	7
1426	S:S:A804	S:S:S794	3.42	No	No	0	9	9
1427	S:S:K796	S:S:R795	3.71	No	No	0	7	9
1428	S:S:K805	S:S:R795	27.23	No	No	0	9	9
1429	S:S:R795	S:S:T808	10.35	No	No	0	9	9
1430	S:S:L797	S:S:P798	4.93	No	No	0	8	9
1431	S:S:F801	S:S:I859	15.07	No	No	0	9	9
1432	S:S:K805	S:S:N802	4.2	No	No	0	9	9
1433	S:S:F806	S:S:N802	19.33	No	No	0	5	9
1434	S:S:E803	S:S:I807	6.83	No	Yes	0	9	9
1435	S:S:E803	S:S:K856	13.5	No	No	0	9	9
1436	S:S:F806	S:S:N855	27.79	No	No	0	5	9
1437	S:S:F809	S:S:I813	6.28	No	No	0	9	8
1438	S:S:C851	S:S:F809	4.19	No	No	0	8	9
1439	S:S:L848	S:S:S810	3	No	No	0	7	9
1440	S:S:C851	S:S:S810	3.44	No	No	0	8	9
1441	S:S:I852	S:S:S810	3.1	No	No	0	9	9
1442	S:S:F814	S:S:W818	23.05	Yes	Yes	0	9	9
1443	S:S:F814	S:S:L848	4.87	Yes	No	0	9	7
1444	S:S:F815	S:S:I819	13.82	No	No	0	7	6
1445	S:S:A843	S:S:V817	3.39	No	No	0	7	9
1446	S:S:A844	S:S:V817	3.39	No	No	0	9	9
1447	S:S:F821	S:S:W818	9.02	Yes	Yes	0	9	9
1448	S:S:F821	S:S:I822	7.54	Yes	No	0	9	7
1449	S:S:F821	S:S:Y825	8.25	Yes	Yes	0	9	9
1450	S:S:E837	S:S:F821	4.66	No	Yes	0	9	9
1451	S:S:A840	S:S:F821	4.16	No	Yes	0	9	9
1452	S:S:I822	S:S:P823	3.39	No	No	0	7	9
1453	S:S:V833	S:S:Y825	3.79	No	Yes	0	6	9
1454	S:S:V836	S:S:Y825	3.79	No	Yes	0	8	9
1455	S:S:T828	S:S:V833	3.17	No	No	0	8	6
1456	S:S:G830	S:S:V833	3.68	No	No	0	8	6
1457	S:S:E837	S:S:I841	4.1	No	No	0	9	9
1458	S:S:F853	S:S:L849	9.74	Yes	No	12	9	8
1459	S:S:F854	S:S:Y858	29.91	No	No	0	4	8
1460	H:H:?1	H:H:?2	27.53	Yes	No	21	0	0
1461	H:H:?3	H:H:?4	35.24	Yes	No	6	0	0
1462	H:H:?4	H:H:?5	34.14	No	No	0	0	0
1463	H:H:?6	H:H:?7	27.53	Yes	No	25	0	0
1464	H:H:?8	H:H:?9	35.24	Yes	No	8	0	0
1465	H:H:?10	H:H:?9	34.14	No	No	0	0	0
1466	R:R:L849	R:R:T627	2.95	No	No	0	8	7
1467	S:S:L849	S:S:T627	2.95	No	No	0	8	7
1468	R:R:I212	R:R:I259	2.94	No	No	0	6	6
1469	R:R:D275	R:R:S272	2.94	No	No	0	5	5
1470	S:S:I212	S:S:I259	2.94	No	No	0	6	6
1471	S:S:D275	S:S:S272	2.94	No	No	0	5	5
1472	R:R:N287	R:R:T289	2.92	No	No	0	6	5
1473	R:R:I807	R:R:M811	2.92	Yes	No	0	9	9
1474	S:S:N287	S:S:T289	2.92	No	No	0	6	5
1475	S:S:I807	S:S:M811	2.92	Yes	No	0	9	9
1476	R:R:G94	R:R:Y95	2.9	No	Yes	0	9	8
1477	S:S:G94	S:S:Y95	2.9	No	Yes	0	9	8
1478	R:R:D217	R:R:T151	2.89	No	No	0	6	5
1479	R:R:D199	R:R:T195	2.89	No	No	0	7	4
1480	S:S:D217	S:S:T151	2.89	No	No	0	6	5
1481	S:S:D199	S:S:T195	2.89	No	No	0	7	4
1482	R:R:K323	R:R:M473	2.88	No	No	0	5	4
1483	S:S:K323	S:S:M473	2.88	No	No	0	5	4
1484	R:R:E251	R:R:S247	2.87	No	No	0	4	2
1485	R:R:E610	R:R:S607	2.87	No	No	0	7	7
1486	S:S:E251	S:S:S247	2.87	No	No	0	4	2
1487	S:S:E610	S:S:S607	2.87	No	No	0	7	7
1488	R:R:E251	R:R:V255	2.85	No	Yes	0	4	5
1489	R:R:I318	R:R:L294	2.85	No	No	0	6	7
1490	R:R:I763	R:R:L606	2.85	No	No	0	7	9
1491	S:S:E251	S:S:V255	2.85	No	Yes	0	4	5
1492	S:S:I318	S:S:L294	2.85	No	No	0	6	7
1493	S:S:I763	S:S:L606	2.85	No	No	0	7	9
1494	R:R:I187	R:R:N419	2.83	No	No	0	6	7
1495	R:R:I599	R:R:N592	2.83	No	No	0	4	7
1496	R:R:Q673	R:R:T676	2.83	No	No	0	4	7
1497	S:S:I187	S:S:N419	2.83	No	No	0	6	7
1498	S:S:I599	S:S:N592	2.83	No	No	0	4	7
1499	S:S:Q673	S:S:T676	2.83	No	No	0	4	7
1500	R:R:E567	R:R:T550	2.82	No	No	0	4	6
1501	R:R:E799	R:R:T699	2.82	No	No	0	8	9
1502	S:S:E567	S:S:T550	2.82	No	No	0	4	6
1503	S:S:E799	S:S:T699	2.82	No	No	0	8	9
1504	R:R:K856	R:R:N800	2.8	No	No	0	9	7
1505	S:S:K856	S:S:N800	2.8	No	No	0	9	7
1506	R:R:C449	R:R:F444	2.79	No	Yes	0	7	3
1507	R:R:C568	R:R:R551	2.79	Yes	No	0	9	7
1508	R:R:C565	R:R:F563	2.79	No	No	0	9	7
1509	S:S:C449	S:S:F444	2.79	No	Yes	0	7	3
1510	S:S:C568	S:S:R551	2.79	Yes	No	0	9	7
1511	S:S:C565	S:S:F563	2.79	No	No	0	9	7
1512	R:R:L112	R:R:L156	2.77	Yes	No	0	5	5
1513	R:R:L112	S:S:L156	2.77	Yes	No	0	5	5
1514	R:R:L156	S:S:L112	2.77	No	Yes	0	5	5
1515	R:R:A198	R:R:F226	2.77	No	No	0	7	6
1516	R:R:A198	R:R:R233	2.77	No	Yes	0	7	4
1517	R:R:L654	R:R:L655	2.77	No	Yes	0	8	9
1518	R:R:A784	R:R:F814	2.77	No	Yes	0	8	9
1519	R:R:A844	R:R:F814	2.77	No	Yes	0	9	9
1520	S:S:L112	S:S:L156	2.77	Yes	No	0	5	5
1521	S:S:A198	S:S:F226	2.77	No	No	0	7	6
1522	S:S:A198	S:S:R233	2.77	No	Yes	0	7	4
1523	S:S:L654	S:S:L655	2.77	No	Yes	0	8	9
1524	S:S:A784	S:S:F814	2.77	No	Yes	0	8	9
1525	S:S:A844	S:S:F814	2.77	No	Yes	0	9	9
1526	R:R:E79	R:R:I75	2.73	No	No	0	7	4
1527	S:S:E79	S:S:I75	2.73	No	No	0	7	4
1528	R:R:N176	R:R:N178	2.72	No	No	0	6	3
1529	S:S:N176	S:S:N178	2.72	No	No	0	6	3
1530	H:H:?13	R:R:S448	2.68	No	No	0	0	3
1531	H:H:?17	S:S:S448	2.68	No	No	0	0	3
1532	R:R:R415	R:R:S490	2.64	No	No	0	5	8
1533	R:R:F533	R:R:S531	2.64	No	No	0	1	4
1534	R:R:F563	R:R:S543	2.64	No	No	0	7	8
1535	R:R:F667	R:R:S664	2.64	No	No	0	5	6
1536	S:S:R415	S:S:S490	2.64	No	No	0	5	8
1537	S:S:F533	S:S:S531	2.64	No	No	0	1	4
1538	S:S:F563	S:S:S543	2.64	No	No	0	7	8
1539	S:S:F667	S:S:S664	2.64	No	No	0	5	6
1540	R:R:E799	R:R:N800	2.63	No	No	0	8	7
1541	S:S:E799	S:S:N800	2.63	No	No	0	8	7
1542	R:R:F351	R:R:V337	2.62	Yes	No	0	6	5
1543	R:R:F356	R:R:V404	2.62	Yes	No	0	8	4
1544	S:S:F351	S:S:V337	2.62	Yes	No	0	6	5
1545	S:S:F356	S:S:V404	2.62	Yes	No	0	8	4
1546	R:R:D433	R:R:Q432	2.61	No	No	0	4	7
1547	S:S:D433	S:S:Q432	2.61	No	No	0	4	7
1548	R:R:F832	R:R:T828	2.59	No	No	0	5	8
1549	S:S:F832	S:S:T828	2.59	No	No	0	5	8
1550	R:R:E757	S:S:E757	2.54	No	No	0	4	4
1551	R:R:V513	R:R:Y511	2.52	No	Yes	0	3	5
1552	S:S:V513	S:S:Y511	2.52	No	Yes	0	3	5
1553	R:R:F662	R:R:I624	2.51	Yes	No	0	8	5
1554	S:S:F662	S:S:I624	2.51	Yes	No	0	8	5
1555	R:R:F183	R:R:K177	2.48	Yes	No	0	8	7
1556	R:R:F333	R:R:K336	2.48	No	No	0	7	4
1557	R:R:F612	R:R:K831	2.48	No	No	0	8	9
1558	R:R:F790	R:R:K793	2.48	No	No	0	7	7
1559	S:S:F183	S:S:K177	2.48	Yes	No	0	8	7
1560	S:S:F333	S:S:K336	2.48	No	No	0	7	4
1561	S:S:F612	S:S:K831	2.48	No	No	0	8	9
1562	S:S:F790	S:S:K793	2.48	No	No	0	7	7
1563	R:R:S534	R:R:W530	2.47	No	Yes	0	4	8
1564	R:R:S591	R:R:W590	2.47	No	No	0	8	6
1565	S:S:S534	S:S:W530	2.47	No	Yes	0	4	8
1566	S:S:S591	S:S:W590	2.47	No	No	0	8	6
1567	R:R:L112	S:S:F160	2.44	Yes	Yes	0	5	7
1568	R:R:F160	S:S:L112	2.44	Yes	Yes	0	7	5
1569	R:R:F846	R:R:L626	2.44	Yes	No	0	6	4
1570	S:S:F846	S:S:L626	2.44	Yes	No	0	6	4
1571	R:R:K584	R:R:Y573	2.39	No	Yes	0	4	6
1572	S:S:K584	S:S:Y573	2.39	No	Yes	0	4	6
1573	H:H:?11	R:R:E257	2.36	No	No	0	0	3
1574	H:H:?15	S:S:E257	2.36	No	No	0	0	3
1575	R:R:I401	R:R:W352	2.35	No	Yes	0	7	8
1576	S:S:I401	S:S:W352	2.35	No	Yes	0	7	8
1577	R:R:F347	R:R:Q24	2.34	Yes	No	0	5	5
1578	S:S:F347	S:S:Q24	2.34	Yes	No	0	5	5
1579	R:R:E332	R:R:R331	2.33	No	No	0	5	4
1580	S:S:E332	S:S:R331	2.33	No	No	0	5	4
1581	R:R:H192	R:R:Y489	2.18	No	Yes	0	4	8
1582	S:S:H192	S:S:Y489	2.18	No	Yes	0	4	8
1583	R:R:F391	R:R:R392	2.14	No	No	0	1	1
1584	R:R:F662	R:R:F846	2.14	Yes	Yes	0	8	6
1585	R:R:F729	R:R:F733	2.14	No	No	0	3	4
1586	S:S:F391	S:S:R392	2.14	No	No	0	1	1
1587	S:S:F662	S:S:F846	2.14	Yes	Yes	0	8	6
1588	S:S:F729	S:S:F733	2.14	No	No	0	3	4
1589	R:R:G30	R:R:G94	2.11	No	No	0	9	9
1590	R:R:G35	R:R:G36	2.11	No	No	0	8	7
1591	R:R:G442	R:R:G447	2.11	No	No	0	4	1
1592	S:S:G30	S:S:G94	2.11	No	No	0	9	9
1593	S:S:G35	S:S:G36	2.11	No	No	0	8	7
1594	S:S:G442	S:S:G447	2.11	No	No	0	4	1
1595	R:R:G487	R:R:P188	2.03	No	No	0	6	8
1596	R:R:G768	R:R:P747	2.03	No	No	0	7	8
1597	S:S:G487	S:S:P188	2.03	No	No	0	6	8
1598	S:S:G768	S:S:P747	2.03	No	No	0	7	8
1599	R:R:C101	R:R:G43	1.96	Yes	No	0	8	2
1600	S:S:C101	S:S:G43	1.96	Yes	No	0	8	2
1601	R:R:A295	R:R:G319	1.95	No	No	0	7	8
1602	R:R:A300	R:R:G319	1.95	No	No	0	6	8
1603	R:R:A324	R:R:G325	1.95	No	No	0	5	4
1604	R:R:A746	R:R:G768	1.95	No	No	0	6	7
1605	R:R:P747	R:R:P748	1.95	No	No	0	8	9
1606	S:S:A295	S:S:G319	1.95	No	No	0	7	8
1607	S:S:A300	S:S:G319	1.95	No	No	0	6	8
1608	S:S:A324	S:S:G325	1.95	No	No	0	5	4
1609	S:S:A746	S:S:G768	1.95	No	No	0	6	7
1610	S:S:P747	S:S:P748	1.95	No	No	0	8	9
1611	R:R:C568	R:R:P569	1.88	Yes	No	0	9	5
1612	R:R:C585	R:R:P586	1.88	Yes	No	0	9	4
1613	S:S:C568	S:S:P569	1.88	Yes	No	0	9	5
1614	S:S:C585	S:S:P586	1.88	Yes	No	0	9	4
1615	R:R:G158	R:R:S182	1.86	No	No	0	6	7
1616	S:S:G158	S:S:S182	1.86	No	No	0	6	7
1617	R:R:G474	R:R:T470	1.82	No	No	0	5	5
1618	S:S:G474	S:S:T470	1.82	No	No	0	5	5
1619	R:R:A784	R:R:C787	1.81	No	No	0	8	8
1620	S:S:A784	S:S:C787	1.81	No	No	0	8	8
1621	R:R:P85	R:R:S84	1.78	No	No	0	3	6
1622	R:R:P308	R:R:S502	1.78	No	No	0	2	4
1623	S:S:P85	S:S:S84	1.78	No	No	0	3	6
1624	S:S:P308	S:S:S502	1.78	No	No	0	2	4
1625	R:R:G43	R:R:I61	1.76	No	No	0	2	2
1626	R:R:G670	R:R:I669	1.76	No	No	0	7	8
1627	S:S:G43	S:S:I61	1.76	No	No	0	2	2
1628	S:S:G670	S:S:I669	1.76	No	No	0	7	8
1629	R:R:P672	R:R:T676	1.75	Yes	No	0	9	7
1630	S:S:P672	S:S:T676	1.75	Yes	No	0	9	7
1631	R:R:G483	R:R:K177	1.74	No	No	0	7	7
1632	R:R:G518	R:R:K517	1.74	No	No	0	3	1
1633	R:R:G632	R:R:K636	1.74	No	No	0	1	4
1634	S:S:G483	S:S:K177	1.74	No	No	0	7	7
1635	S:S:G518	S:S:K517	1.74	No	No	0	3	1
1636	S:S:G632	S:S:K636	1.74	No	No	0	1	4
1637	R:R:C542	R:R:S543	1.72	No	No	6	9	8
1638	R:R:C562	R:R:S543	1.72	Yes	No	6	9	8
1639	S:S:C542	S:S:S543	1.72	No	No	8	9	8
1640	S:S:C562	S:S:S543	1.72	Yes	No	8	9	8
1641	R:R:A348	R:R:S342	1.71	No	No	0	5	3
1642	R:R:G532	R:R:L529	1.71	No	No	0	1	4
1643	R:R:G774	R:R:L773	1.71	No	No	0	4	8
1644	R:R:G778	R:R:L782	1.71	No	No	0	5	4
1645	R:R:A791	R:R:S794	1.71	No	No	0	9	9
1646	S:S:A348	S:S:S342	1.71	No	No	0	5	3
1647	S:S:G532	S:S:L529	1.71	No	No	0	1	4
1648	S:S:G774	S:S:L773	1.71	No	No	0	4	8
1649	S:S:G778	S:S:L782	1.71	No	No	0	5	4
1650	S:S:A791	S:S:S794	1.71	No	No	0	9	9
1651	R:R:A45	R:R:V58	1.7	No	No	0	1	1
1652	R:R:A430	R:R:V460	1.7	No	No	0	8	7
1653	R:R:A824	R:R:V836	1.7	No	No	0	7	8
1654	S:S:A45	S:S:V58	1.7	No	No	0	1	1
1655	S:S:A824	S:S:V836	1.7	No	No	0	7	8
1656	R:R:I686	R:R:P682	1.69	Yes	No	0	7	5
1657	S:S:I686	S:S:P682	1.69	Yes	No	0	7	5
1658	R:R:A791	R:R:T808	1.68	No	No	0	9	9
1659	S:S:A791	S:S:T808	1.68	No	No	0	9	9
1660	R:R:K349	R:R:P339	1.67	No	Yes	0	3	7
1661	S:S:K349	S:S:P339	1.67	No	Yes	0	3	7
1662	R:R:G346	R:R:Q24	1.64	No	No	0	3	5
1663	R:R:E564	R:R:G553	1.64	No	No	0	6	6
1664	R:R:C731	R:R:I692	1.64	No	Yes	3	5	7
1665	R:R:C694	R:R:I695	1.64	No	No	0	6	7
1666	S:S:G346	S:S:Q24	1.64	No	No	0	3	5
1667	S:S:E564	S:S:G553	1.64	No	No	0	6	6
1668	S:S:C731	S:S:I692	1.64	No	Yes	4	5	7
1669	S:S:C694	S:S:I695	1.64	No	No	0	6	7
1670	R:R:N102	R:R:P274	1.63	No	Yes	0	3	3
1671	R:R:S244	R:R:S247	1.63	No	No	0	4	2
1672	S:S:N102	S:S:P274	1.63	No	Yes	0	3	3
1673	S:S:S244	S:S:S247	1.63	No	No	0	4	2
1674	R:R:A116	R:R:I135	1.62	No	No	0	6	4
1675	R:R:A683	R:R:I841	1.62	No	No	0	5	9
1676	R:R:S820	R:R:V817	1.62	No	No	0	7	9
1677	S:S:A116	S:S:I135	1.62	No	No	0	6	4
1678	S:S:A683	S:S:I841	1.62	No	No	0	5	9
1679	S:S:S820	S:S:V817	1.62	No	No	0	7	9
1680	R:R:S597	R:R:T596	1.6	No	No	0	1	5
1681	S:S:S597	S:S:T596	1.6	No	No	0	1	5
1682	R:R:T289	R:R:V313	1.59	No	No	0	5	3
1683	S:S:T289	S:S:V313	1.59	No	No	0	5	3
1684	R:R:A600	R:R:N592	1.56	No	No	0	4	7
1685	S:S:A600	S:S:N592	1.56	No	No	0	4	7
1686	R:R:A450	R:R:D451	1.54	No	No	0	3	3
1687	R:R:I736	R:R:V740	1.54	No	No	0	5	3
1688	S:S:A450	S:S:D451	1.54	No	No	0	3	3
1689	S:S:I736	S:S:V740	1.54	No	No	0	5	3
1690	R:R:C482	R:R:E481	1.52	No	No	0	7	4
1691	S:S:C482	S:S:E481	1.52	No	No	0	7	4
1692	R:R:F533	R:R:G532	1.51	No	No	0	1	1
1693	R:R:E564	S:S:A581	1.51	No	No	0	6	4
1694	R:R:A581	S:S:E564	1.51	No	No	0	4	6
1695	R:R:F846	R:R:G847	1.51	Yes	No	0	6	8
1696	S:S:F533	S:S:G532	1.51	No	No	0	1	1
1697	S:S:F846	S:S:G847	1.51	Yes	No	0	6	8
1698	R:R:K52	S:S:T445	1.5	No	No	0	3	1
1699	R:R:L87	R:R:S84	1.5	No	No	0	6	6
1700	R:R:T445	S:S:K52	1.5	No	No	0	1	3
1701	R:R:L650	R:R:S651	1.5	No	No	0	8	9
1702	R:R:L797	R:R:S794	1.5	No	No	0	8	9
1703	S:S:L87	S:S:S84	1.5	No	No	0	6	6
1704	S:S:L650	S:S:S651	1.5	No	No	0	8	9
1705	S:S:L797	S:S:S794	1.5	No	No	0	8	9
1706	R:R:N118	R:R:S137	1.49	No	No	0	4	4
1707	R:R:L616	R:R:V838	1.49	No	No	0	8	7
1708	S:S:N118	S:S:S137	1.49	No	No	0	4	4
1709	S:S:L616	S:S:V838	1.49	No	No	0	8	7
1710	R:R:L618	R:R:T617	1.47	No	No	0	4	5
1711	S:S:L618	S:S:T617	1.47	No	No	0	4	5
1712	R:R:G830	R:R:Y829	1.45	No	No	0	8	6
1713	R:R:I859	R:R:K856	1.45	No	No	0	9	9
1714	S:S:G830	S:S:Y829	1.45	No	No	0	8	6
1715	S:S:I859	S:S:K856	1.45	No	No	0	9	9
1716	R:R:P393	R:R:R392	1.44	No	No	0	1	1
1717	S:S:P393	S:S:R392	1.44	No	No	0	1	1
1718	R:R:I120	R:R:N124	1.42	No	No	0	3	6
1719	S:S:I120	S:S:N124	1.42	No	No	0	3	6
1720	R:R:K119	R:R:L112	1.41	No	Yes	0	3	5
1721	R:R:K119	S:S:L123	1.41	No	No	0	3	5
1722	R:R:L123	S:S:K119	1.41	No	No	0	5	3
1723	S:S:K119	S:S:L112	1.41	No	Yes	0	3	5
1724	R:R:A850	R:R:F846	1.39	No	Yes	0	1	6
1725	S:S:A850	S:S:F846	1.39	No	Yes	0	1	6
1726	R:R:H312	R:R:V313	1.38	No	No	0	3	3
1727	R:R:H495	R:R:V504	1.38	Yes	No	0	7	3
1728	R:R:D587	R:R:K584	1.38	No	No	0	3	4
1729	R:R:D588	R:R:K601	1.38	No	No	0	6	8
1730	S:S:H312	S:S:V313	1.38	No	No	0	3	3
1731	S:S:H495	S:S:V504	1.38	Yes	No	0	7	3
1732	S:S:D587	S:S:K584	1.38	No	No	0	3	4
1733	S:S:D588	S:S:K601	1.38	No	No	0	6	8
1734	R:R:E231	R:R:I237	1.37	No	No	0	4	6
1735	S:S:E231	S:S:I237	1.37	No	No	0	4	6
1736	R:R:E649	R:R:L653	1.33	No	No	0	7	5
1737	S:S:E649	S:S:L653	1.33	No	No	0	7	5
1738	R:R:R66	R:R:S301	1.32	Yes	No	0	5	5
1739	S:S:R66	S:S:S301	1.32	Yes	No	0	5	5
1740	R:R:E593	R:R:N594	1.31	No	No	0	2	3
1741	S:S:E593	S:S:N594	1.31	No	No	0	2	3
1742	R:R:E229	R:R:E232	1.27	No	No	0	5	4
1743	R:R:E475	R:R:Q476	1.27	No	No	0	5	3
1744	S:S:E229	S:S:E232	1.27	No	No	0	5	4
1745	S:S:E475	S:S:Q476	1.27	No	No	0	5	3
1746	R:R:H359	R:R:Q361	1.24	No	No	0	4	1
1747	S:S:H359	S:S:Q361	1.24	No	No	0	4	1
1748	R:R:F629	R:R:L626	1.22	No	No	0	3	4
1749	R:R:F725	R:R:L696	1.22	No	No	3	5	8
1750	S:S:F629	S:S:L626	1.22	No	No	0	3	4
1751	S:S:F725	S:S:L696	1.22	No	No	4	5	8
1752	R:R:F801	R:R:N802	1.21	No	No	0	9	9
1753	R:R:F854	R:R:N855	1.21	No	No	0	4	9
1754	R:R:I857	R:R:Y858	1.21	Yes	No	0	8	8
1755	S:S:F801	S:S:N802	1.21	No	No	0	9	9
1756	S:S:F854	S:S:N855	1.21	No	No	0	4	9
1757	S:S:I857	S:S:Y858	1.21	Yes	No	0	8	8
1758	R:R:H359	R:R:R392	1.13	No	No	0	4	1
1759	S:S:H359	S:S:R392	1.13	No	No	0	4	1
1760	R:R:F788	R:R:F792	1.07	No	No	0	8	8
1761	S:S:F788	S:S:F792	1.07	No	No	0	8	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F38	5.98333	6	1	7
2	R:R:P39	5.4325	4	1	6
3	R:R:I40	5.37	4	1	5
4	R:R:H41	5.778	5	1	7
5	R:R:F42	8.898	5	32	3
6	R:R:L51	4.678	5	17	6
7	R:R:Y63	5.23143	7	1	5
8	R:R:N64	6.315	4	0	4
9	R:R:F65	6.394	5	1	2
10	R:R:R66	4.428	5	0	5
11	R:R:F68	7.3675	4	1	7
12	R:R:W70	7.03833	6	1	5
13	R:R:F76	6.798	5	13	7
14	R:R:Y95	9.01	5	0	8
15	R:R:R96	4.4025	4	0	4
16	R:R:I97	6.0575	4	1	8
17	R:R:F98	6.48	5	0	4
18	R:R:D99	5.4575	4	1	9
19	R:R:C101	4.9525	4	1	8
20	R:R:V104	4.94	4	9	4
21	R:R:K106	3.0875	4	0	4
22	R:R:L112	2.3475	4	0	5
23	R:R:F114	5.18167	6	0	5
24	R:R:L125	7.845	4	0	4
25	R:R:T145	4.66833	6	1	5
26	R:R:L157	4.395	4	31	7
27	R:R:F160	6.728	5	0	7
28	R:R:Y161	7.74	4	18	4
29	R:R:I162	4.216	5	0	6
30	R:R:P163	4.245	4	0	8
31	R:R:Y167	6.698	5	1	8
32	R:R:S169	4.326	5	10	8
33	R:R:L174	5.86571	7	10	7
34	R:R:F180	5.956	5	10	5
35	R:R:F183	7.74833	6	10	8
36	R:R:N189	4.1425	4	0	8
37	R:R:D190	7.0125	4	19	8
38	R:R:Q193	6.038	5	19	9
39	R:R:I201	4.2	4	5	6
40	R:R:F204	8.028	5	5	7
41	R:R:W206	8.34167	6	5	9
42	R:R:N207	8.6725	4	6	6
43	R:R:W208	8.78667	6	6	9
44	R:R:V209	4.4425	4	5	8
45	R:R:Y218	5.74333	6	19	7
46	R:R:R227	8.5025	4	0	4
47	R:R:R233	4.868	5	0	4
48	R:R:I235	4.4375	4	5	7
49	R:R:F239	6.9475	4	6	6
50	R:R:V255	4.0225	4	0	5
51	R:R:V266	6.30167	6	5	7
52	R:R:F270	5.805	6	19	7
53	R:R:P274	4.0475	4	32	3
54	R:R:I280	5.3	4	0	5
55	R:R:I283	3.87	4	0	4
56	R:R:R286	7.97	5	27	4
57	R:R:W299	7.232	5	14	7
58	R:R:Y310	6.0375	4	34	3
59	R:R:I327	5.478	5	13	6
60	R:R:F330	5.84857	7	13	8
61	R:R:P339	10.325	4	0	7
62	R:R:F347	3.392	5	1	5
63	R:R:F351	7.025	6	1	6
64	R:R:W352	11.164	5	1	8
65	R:R:T355	6.6225	4	1	4
66	R:R:F356	11.265	4	1	8
67	R:R:E399	6.984	5	1	8
68	R:R:Y408	7.5025	4	1	3
69	R:R:Y411	9.325	4	0	5
70	R:R:L414	5.17	4	13	6
71	R:R:Y418	5.206	5	20	7
72	R:R:Y421	7.954	5	13	8
73	R:R:F444	5.385	4	0	3
74	R:R:W458	10.16	5	18	4
75	R:R:Q459	8.085	4	18	7
76	R:R:N471	4.655	4	20	6
77	R:R:N488	11.6275	4	21	4
78	R:R:Y489	3.612	5	0	8
79	R:R:W494	6.54875	8	14	7
80	R:R:H495	6.7875	4	0	7
81	R:R:S497	4.0625	4	35	3
82	R:R:I503	4.295	4	14	4
83	R:R:Y511	5.098	5	0	5
84	R:R:N512	6.822	5	21	4
85	R:R:Y514	6.44	4	21	4
86	R:R:I523	7.22	4	5	6
87	R:R:W530	7.65857	7	5	8
88	R:R:C562	4.6425	4	6	9
89	R:R:C568	6.405	4	28	9
90	R:R:E572	10.2725	4	28	7
91	R:R:Y573	11.324	5	40	6
92	R:R:C585	5.285	4	40	9
93	R:R:V630	7.5825	4	11	7
94	R:R:F634	10.6825	4	11	9
95	R:R:L655	4.5125	4	11	9
96	R:R:F662	5.052	5	0	8
97	R:R:F668	7.855	4	0	9
98	R:R:P672	4.8325	4	22	9
99	R:R:F684	15.505	4	3	8
100	R:R:I686	4.4725	4	0	7
101	R:R:F688	10.99	4	3	8
102	R:R:L690	5.2925	4	11	7
103	R:R:I692	7.7825	4	3	7
104	R:R:Q735	13.67	5	3	9
105	R:R:W742	13.515	4	3	9
106	R:R:N753	6.2675	4	42	7
107	R:R:F762	7.31	4	42	7
108	R:R:C765	6.49	4	22	9
109	R:R:M771	12.1875	4	3	3
110	R:R:F775	13.0067	6	3	4
111	R:R:Y779	17.18	6	3	9
112	R:R:I807	6.4775	4	0	9
113	R:R:F814	8.365	4	0	9
114	R:R:W818	10.59	4	0	9
115	R:R:F821	6.726	5	0	9
116	R:R:Y825	5.08	4	0	9
117	R:R:L842	5.655	4	0	9
118	R:R:F846	1.87	4	0	6
119	R:R:F853	9.716	5	11	9
120	R:R:I857	6.8275	4	11	8
121	S:S:F38	5.98333	6	2	7
122	S:S:P39	5.4325	4	2	6
123	S:S:I40	5.37	4	2	5
124	S:S:H41	5.778	5	2	7
125	S:S:F42	8.898	5	44	3
126	S:S:L51	4.79	4	18	6
127	S:S:Y63	5.23143	7	2	5
128	S:S:N64	6.315	4	0	4
129	S:S:F65	6.394	5	2	2
130	S:S:R66	4.428	5	0	5
131	S:S:F68	7.3675	4	2	7
132	S:S:W70	7.03833	6	2	5
133	S:S:F76	6.798	5	15	7
134	S:S:Y95	9.01	5	0	8
135	S:S:R96	4.4025	4	0	4
136	S:S:I97	6.0575	4	2	8
137	S:S:F98	6.48	5	0	4
138	S:S:D99	5.4575	4	2	9
139	S:S:C101	4.9525	4	2	8
140	S:S:V104	4.94	4	10	4
141	S:S:K106	3.0875	4	0	4
142	S:S:L112	2.3475	4	0	5
143	S:S:F114	5.18167	6	0	5
144	S:S:L125	7.845	4	0	4
145	S:S:T145	4.66833	6	2	5
146	S:S:L157	4.395	4	43	7
147	S:S:F160	6.728	5	0	7
148	S:S:Y161	7.74	4	17	4
149	S:S:I162	4.216	5	0	6
150	S:S:P163	4.245	4	0	8
151	S:S:Y167	6.698	5	2	8
152	S:S:S169	4.326	5	9	8
153	S:S:L174	5.86571	7	9	7
154	S:S:F180	5.956	5	9	5
155	S:S:F183	7.74833	6	9	8
156	S:S:N189	4.1425	4	0	8
157	S:S:D190	7.0125	4	23	8
158	S:S:Q193	6.038	5	23	9
159	S:S:I201	4.2	4	7	6
160	S:S:F204	8.028	5	7	7
161	S:S:W206	8.34167	6	7	9
162	S:S:N207	8.6725	4	8	6
163	S:S:W208	8.78667	6	8	9
164	S:S:V209	4.4425	4	7	8
165	S:S:Y218	5.74333	6	23	7
166	S:S:R227	8.5025	4	0	4
167	S:S:R233	4.868	5	0	4
168	S:S:I235	4.4375	4	7	7
169	S:S:F239	6.9475	4	8	6
170	S:S:V255	4.0225	4	0	5
171	S:S:V266	6.30167	6	7	7
172	S:S:F270	5.805	6	23	7
173	S:S:P274	4.0475	4	44	3
174	S:S:I280	5.3	4	0	5
175	S:S:I283	3.87	4	0	4
176	S:S:R286	7.97	5	29	4
177	S:S:W299	7.232	5	16	7
178	S:S:Y310	6.0375	4	45	3
179	S:S:I327	5.478	5	15	6
180	S:S:F330	5.84857	7	15	8
181	S:S:P339	10.325	4	0	7
182	S:S:F347	3.392	5	2	5
183	S:S:F351	7.025	6	2	6
184	S:S:W352	11.164	5	2	8
185	S:S:T355	6.6225	4	2	4
186	S:S:F356	11.265	4	2	8
187	S:S:E399	6.984	5	2	8
188	S:S:Y408	7.5025	4	2	3
189	S:S:Y411	9.325	4	0	5
190	S:S:L414	5.17	4	15	6
191	S:S:Y418	5.206	5	24	7
192	S:S:Y421	7.954	5	15	8
193	S:S:F444	5.385	4	0	3
194	S:S:W458	10.16	5	17	4
195	S:S:Q459	8.085	4	17	7
196	S:S:N471	4.655	4	24	6
197	S:S:N488	11.6275	4	25	4
198	S:S:Y489	3.612	5	0	8
199	S:S:W494	6.54875	8	16	7
200	S:S:H495	6.7875	4	0	7
201	S:S:S497	4.0625	4	46	3
202	S:S:I503	4.295	4	16	4
203	S:S:Y511	5.098	5	0	5
204	S:S:N512	6.822	5	25	4
205	S:S:Y514	6.44	4	25	4
206	S:S:I523	7.22	4	7	6
207	S:S:W530	7.65857	7	7	8
208	S:S:C562	4.6425	4	8	9
209	S:S:C568	6.405	4	30	9
210	S:S:E572	10.2725	4	30	7
211	S:S:Y573	11.324	5	48	6
212	S:S:C585	5.285	4	48	9
213	S:S:V630	7.5825	4	12	7
214	S:S:F634	10.6825	4	12	9
215	S:S:L655	4.5125	4	12	9
216	S:S:F662	5.052	5	0	8
217	S:S:F668	7.855	4	0	9
218	S:S:P672	4.8325	4	26	9
219	S:S:F684	15.505	4	4	8
220	S:S:I686	4.4725	4	0	7
221	S:S:F688	10.99	4	4	8
222	S:S:L690	5.2925	4	12	7
223	S:S:I692	7.7825	4	4	7
224	S:S:Q735	13.67	5	4	9
225	S:S:W742	13.515	4	4	9
226	S:S:N753	6.2675	4	50	7
227	S:S:F762	7.31	4	50	7
228	S:S:C765	6.49	4	26	9
229	S:S:M771	12.1875	4	4	3
230	S:S:F775	13.0067	6	4	4
231	S:S:Y779	17.18	6	4	9
232	S:S:I807	6.4775	4	0	9
233	S:S:F814	8.365	4	0	9
234	S:S:W818	10.59	4	0	9
235	S:S:F821	6.726	5	0	9
236	S:S:Y825	5.08	4	0	9
237	S:S:L842	5.655	4	0	9
238	S:S:F846	1.87	4	0	6
239	S:S:F853	9.716	5	12	9
240	S:S:I857	6.8275	4	12	8
241	W:W:W1101	4.51167	6	1	0
242	X:X:W1101	4.51167	6	2	0
243	H:H:?1	19.832	5	21	0
244	H:H:?3	17.112	5	6	0
245	H:H:?6	19.832	5	25	0
246	H:H:?8	17.112	5	8	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F98	R:R:R96	10.764	5.34	Yes	Yes	0	4	4
2	R:R:F38	R:R:L71	94.9991	6.09	Yes	No	1	7	4
3	R:R:I40	R:R:L71	56.6199	4.28	Yes	No	1	5	4
4	R:R:I40	R:R:Y63	19.0612	3.63	Yes	Yes	1	5	5
5	R:R:H41	R:R:Y63	22.4234	5.44	Yes	Yes	1	7	5
6	R:R:C60	R:R:H41	59.609	8.85	No	Yes	1	7	7
7	R:R:C60	R:R:K106	96.5215	3.23	No	Yes	0	7	4
8	R:R:K106	R:R:S105	89.3543	3.06	Yes	No	0	4	4
9	R:R:S105	S:S:L159	89.2368	3	No	No	0	4	5
10	S:S:F160	S:S:L159	89.1301	6.09	Yes	No	0	7	5
11	R:R:L112	S:S:F160	62.3735	2.44	Yes	Yes	0	5	7
12	R:R:D99	R:R:I40	37.4993	9.8	Yes	Yes	1	9	5
13	R:R:D99	R:R:H41	37.3868	3.78	Yes	Yes	1	9	7
14	R:R:F347	R:R:L71	38.3306	3.65	Yes	No	1	5	4
15	R:R:D99	R:R:F347	37.757	3.58	Yes	Yes	1	9	5
16	R:R:C101	R:R:D99	37.769	4.67	Yes	Yes	1	8	9
17	R:R:C101	R:R:C60	37.3398	7.28	Yes	No	1	8	7
18	R:R:F469	R:R:H429	11.2681	21.5	No	No	0	8	6
19	R:R:F479	R:R:L184	30.9308	6.09	No	No	0	8	6
20	R:R:L184	R:R:L464	31.6323	5.54	No	No	0	6	7
21	R:R:L464	R:R:P163	32.334	3.28	No	Yes	0	7	8
22	R:R:I162	R:R:P163	38.6521	3.39	Yes	Yes	0	6	8
23	R:R:I162	R:R:L157	23.3679	5.71	Yes	Yes	0	6	7
24	R:R:F114	R:R:F98	15.1564	7.5	Yes	Yes	0	5	4
25	R:R:L485	R:R:V477	21.7948	5.96	No	No	0	4	6
26	R:R:F479	R:R:L485	22.4967	6.09	No	No	0	8	4
27	R:R:F38	R:R:P39	49.2045	4.33	Yes	Yes	1	7	6
28	R:R:F38	R:R:Y167	47.4451	10.32	Yes	Yes	1	7	8
29	R:R:P39	R:R:T145	47.0196	8.74	Yes	Yes	1	6	5
30	R:R:T145	R:R:Y167	47.1838	4.99	Yes	Yes	1	5	8
31	R:R:T103	R:R:V44	16.2719	6.35	No	No	0	4	2
32	R:R:K106	R:R:T103	16.6252	3	Yes	No	0	4	4
33	R:R:V44	R:R:V58	15.9188	6.41	No	No	0	2	1
34	R:R:K47	R:R:V58	15.2126	3.04	No	No	0	2	1
35	R:R:K47	R:R:Q49	14.8599	4.07	No	No	0	2	1
36	R:R:Q49	S:S:Y161	14.508	6.76	No	Yes	0	1	4
37	R:R:L51	S:S:Y161	10.9801	3.52	Yes	Yes	17	6	4
38	R:R:R66	R:R:R69	10.4991	3.2	Yes	No	0	5	8
39	R:R:T145	W:W:W1101	92.2809	3.64	Yes	Yes	1	5	0
40	S:S:A144	S:S:S150	16.286	3.42	No	No	0	6	8
41	S:S:A144	S:S:V149	16.5658	3.39	No	No	0	6	4
42	S:S:G146	S:S:V149	16.8456	3.68	No	No	0	5	4
43	S:S:G146	S:S:T145	17.1253	3.64	No	Yes	0	5	5
44	S:S:P39	S:S:T145	48.7803	8.74	Yes	Yes	2	6	5
45	S:S:F38	S:S:P39	50.9508	4.33	Yes	Yes	2	7	6
46	S:S:F38	S:S:L71	98.4935	6.09	Yes	No	2	7	4
47	S:S:I40	S:S:L71	58.7163	4.28	Yes	No	2	5	4
48	S:S:I40	S:S:Y63	19.7598	3.63	Yes	Yes	2	5	5
49	S:S:H41	S:S:Y63	23.109	5.44	Yes	Yes	2	7	5
50	S:S:C60	S:S:H41	61.6911	8.85	No	Yes	2	7	7
51	S:S:C60	S:S:K106	100	3.23	No	Yes	0	7	4
52	S:S:K106	S:S:S105	89.149	3.06	Yes	No	0	4	4
53	R:R:L159	S:S:S105	89.0307	3	No	No	0	5	4
54	R:R:F160	R:R:L159	88.9232	6.09	Yes	No	0	7	5
55	R:R:F160	R:R:V115	31.9461	13.11	Yes	No	0	7	5
56	R:R:I162	R:R:V115	31.5973	3.07	Yes	No	0	6	5
57	S:S:T145	S:S:Y167	48.9445	4.99	Yes	Yes	2	5	8
58	S:S:F38	S:S:Y167	49.2023	10.32	Yes	Yes	2	7	8
59	S:S:D99	S:S:I40	38.8967	9.8	Yes	Yes	2	9	5
60	S:S:D99	S:S:H41	38.7836	3.78	Yes	Yes	2	9	7
61	S:S:F347	S:S:L71	39.7282	3.65	Yes	No	2	5	4
62	S:S:D99	S:S:F347	39.1534	3.58	Yes	Yes	2	9	5
63	S:S:C101	S:S:D99	39.1658	4.67	Yes	Yes	2	8	9
64	S:S:C101	S:S:C60	38.7363	7.28	Yes	No	2	8	7
65	R:R:F160	R:R:N118	34.4056	4.83	Yes	No	0	7	4
66	R:R:I162	R:R:N118	31.615	5.66	Yes	No	0	6	4
67	R:R:A144	R:R:V149	16.6246	3.39	No	No	0	6	4
68	R:R:G146	R:R:V149	16.9054	3.68	No	No	0	5	4
69	R:R:G146	R:R:T145	17.1861	3.64	No	Yes	0	5	5
70	R:R:A144	R:R:S150	16.3438	3.42	No	No	0	6	8
71	R:R:Y161	S:S:Q49	21.4072	6.76	Yes	No	0	4	1
72	S:S:K47	S:S:Q49	21.7578	4.07	No	No	0	2	1
73	S:S:K47	S:S:V58	22.1099	3.04	No	No	0	2	1
74	S:S:V44	S:S:V58	22.8141	6.41	No	No	0	2	1
75	S:S:T103	S:S:V44	23.1663	6.35	No	No	0	4	2
76	S:S:K106	S:S:T103	23.5188	3	Yes	No	0	4	4
77	R:R:Y161	S:S:L51	10.5294	3.52	Yes	Yes	18	4	6
78	R:R:Y161	S:S:P55	10.1768	11.13	Yes	No	18	4	6
79	R:R:E297	R:R:Q193	91.6549	5.1	No	Yes	0	8	9
80	R:R:E297	W:W:W1101	91.7788	6.54	No	Yes	0	8	0
81	R:R:Q193	R:R:Y489	87.5551	5.64	Yes	Yes	0	9	8
82	R:R:A298	R:R:Y218	13.505	4	No	Yes	0	6	7
83	R:R:A298	W:W:W1101	13.5473	6.48	No	Yes	0	6	0
84	R:R:F270	R:R:Q193	21.2109	4.68	Yes	Yes	19	7	9
85	R:R:F270	R:R:Y218	12.4597	9.28	Yes	Yes	19	7	7
86	R:R:D199	R:R:Y511	75.4064	3.45	No	Yes	0	7	5
87	R:R:Y489	R:R:Y511	77.8336	2.98	Yes	Yes	0	8	5
88	R:R:D199	R:R:R233	74.3954	5.96	No	Yes	0	7	4
89	R:R:I235	R:R:R233	73.5756	3.76	Yes	Yes	0	7	4
90	R:R:I235	R:R:V209	72.8821	3.07	Yes	Yes	5	7	8
91	R:R:D238	R:R:W208	63.9211	13.4	No	Yes	6	8	9
92	R:R:D238	R:R:F239	64.0468	9.55	No	Yes	6	8	6
93	R:R:F239	R:R:G210	74.9576	9.03	Yes	No	0	6	8
94	R:R:G210	R:R:V209	75.119	3.68	No	Yes	0	8	8
95	R:R:C542	R:R:W208	30.4252	18.28	No	Yes	6	9	9
96	R:R:C562	R:R:W208	30.7984	6.53	Yes	Yes	6	9	9
97	R:R:F270	R:R:I223	34.1217	3.77	Yes	No	0	7	5
98	R:R:I223	R:R:T211	33.9375	7.6	No	No	0	5	5
99	R:R:I237	R:R:T211	17.0025	3.04	No	No	0	6	5
100	R:R:S240	R:R:T211	16.8561	3.2	No	No	0	4	5
101	R:R:E241	R:R:V255	13.9071	5.7	No	Yes	0	5	5
102	R:R:E241	R:R:H254	14.1233	6.15	No	No	0	5	3
103	R:R:H254	R:R:V258	14.3395	4.15	No	No	0	3	4
104	R:R:F239	R:R:V258	14.5557	3.93	Yes	No	0	6	4
105	R:R:I237	R:R:R227	17.0966	11.27	No	Yes	0	6	4
106	R:R:R227	R:R:S240	16.9032	7.91	Yes	No	0	4	4
107	R:R:R227	S:S:R227	33.7265	3.2	Yes	Yes	0	4	4
108	S:S:I237	S:S:R227	17.1232	11.27	No	Yes	0	6	4
109	S:S:I237	S:S:T211	17.0689	3.04	No	No	0	6	5
110	S:S:I223	S:S:T211	34.1009	7.6	No	No	0	5	5
111	S:S:F270	S:S:I223	34.3516	3.77	Yes	No	0	7	5
112	S:S:F270	S:S:Q193	21.4135	4.68	Yes	Yes	23	7	9
113	S:S:E297	S:S:Q193	95.0493	5.1	No	Yes	0	8	9
114	S:S:E297	X:X:W1101	95.1713	6.54	No	Yes	0	8	0
115	S:S:T145	X:X:W1101	95.865	3.64	Yes	Yes	2	5	0
116	S:S:R227	S:S:S240	16.943	7.91	Yes	No	0	4	4
117	S:S:S240	S:S:T211	16.9159	3.2	No	No	0	4	5
118	S:S:F270	S:S:Y218	12.6623	9.28	Yes	Yes	23	7	7
119	S:S:A298	S:S:Y218	13.6987	4	No	Yes	0	6	7
120	S:S:A298	X:X:W1101	13.7399	6.48	No	Yes	0	6	0
121	R:R:I283	R:R:L279	11.5265	4.28	Yes	No	0	4	5
122	R:R:L279	R:R:V255	11.7431	4.47	No	Yes	0	5	5
123	R:R:N471	R:R:V477	14.7813	5.91	Yes	No	0	6	6
124	R:R:F444	R:R:Q459	14.7233	9.37	Yes	Yes	0	3	7
125	R:R:Q459	R:R:W458	17.538	12.05	Yes	Yes	18	7	4
126	R:R:F563	R:R:S543	60.4069	2.64	No	No	0	7	8
127	R:R:C542	R:R:S543	30.2657	1.72	No	No	6	9	8
128	R:R:C562	R:R:S543	30.3356	1.72	Yes	No	6	9	8
129	R:R:C565	R:R:F563	56.3316	2.79	No	No	0	9	7
130	R:R:C565	R:R:T550	55.7829	3.38	No	No	36	9	6
131	S:S:E567	S:S:H595	58.4515	8.62	No	No	0	4	5
132	S:S:E567	S:S:T550	58.7168	2.82	No	No	0	4	6
133	S:S:C565	S:S:T550	58.9741	3.38	No	No	47	9	6
134	S:S:C565	S:S:F563	59.5129	2.79	No	No	0	9	7
135	S:S:F563	S:S:S543	63.7732	2.64	No	No	0	7	8
136	S:S:C542	S:S:S543	31.9523	1.72	No	No	8	9	8
137	S:S:C542	S:S:W208	32.1108	18.28	No	Yes	8	9	9
138	S:S:D238	S:S:W208	67.2734	13.4	No	Yes	8	8	9
139	S:S:D238	S:S:F239	67.3981	9.55	No	Yes	8	8	6
140	S:S:F239	S:S:G210	78.2401	9.03	Yes	No	0	6	8
141	S:S:G210	S:S:V209	78.4006	3.68	No	Yes	0	8	8
142	S:S:I235	S:S:V209	76.1627	3.07	Yes	Yes	7	7	8
143	S:S:I235	S:S:R233	76.8521	3.76	Yes	Yes	0	7	4
144	S:S:D199	S:S:R233	77.667	5.96	No	Yes	0	7	4
145	S:S:D199	S:S:Y511	78.672	3.45	No	Yes	0	7	5
146	S:S:Y489	S:S:Y511	81.0853	2.98	Yes	Yes	0	8	5
147	S:S:Q193	S:S:Y489	90.7539	5.64	Yes	Yes	0	9	8
148	S:S:C562	S:S:S543	32.0223	1.72	Yes	No	8	9	8
149	S:S:C562	S:S:W208	32.482	6.53	Yes	Yes	8	9	9
150	R:R:E567	R:R:H595	55.2503	8.62	No	No	0	4	5
151	R:R:E567	R:R:T550	55.5206	2.82	No	No	0	4	6
152	R:R:H595	R:R:S591	52.1376	4.18	No	No	0	5	8
153	R:R:F605	R:R:F762	47.5572	8.57	No	Yes	0	7	7
154	R:R:F605	R:R:I603	47.7893	33.91	No	No	0	7	4
155	R:R:E759	R:R:I603	48.0213	5.47	No	No	0	4	4
156	R:R:D758	R:R:E759	48.2533	6.5	No	No	0	4	4
157	R:R:D758	R:R:W590	48.4852	15.63	No	No	0	4	6
158	R:R:S591	R:R:W590	48.5824	2.47	No	No	0	8	6
159	R:R:E757	R:R:W590	40.3981	4.36	No	No	0	4	6
160	R:R:E757	S:S:E757	40.3918	2.54	No	No	0	4	4
161	S:S:E757	S:S:W590	40.4114	4.36	No	No	0	4	6
162	S:S:S591	S:S:W590	51.3455	2.47	No	No	0	8	6
163	S:S:H595	S:S:S591	55.1664	4.18	No	No	0	5	8
164	R:R:E837	R:R:F821	18.7353	4.66	No	Yes	0	9	9
165	R:R:F821	R:R:Y825	41.9778	8.25	Yes	Yes	0	9	9
166	R:R:V833	R:R:Y825	42.909	3.79	No	Yes	0	6	9
167	R:R:G830	R:R:V833	43.8397	3.68	No	No	0	8	6
168	R:R:G830	R:R:Y829	44.0723	1.45	No	No	0	8	6
169	R:R:E755	R:R:Y829	44.3049	3.37	No	No	0	4	6
170	R:R:E755	R:R:F762	44.5248	7	No	Yes	42	4	7
171	R:R:L842	R:R:S665	12.1118	4.5	Yes	No	0	9	8
172	R:R:I841	R:R:S665	12.3482	3.1	No	No	0	9	8
173	R:R:E837	R:R:I841	12.8221	4.1	No	No	0	9	9
174	R:R:F662	R:R:L842	11.4027	3.65	Yes	Yes	0	8	9
175	R:R:F821	R:R:W818	22.5096	9.02	Yes	Yes	0	9	9
176	S:S:G830	S:S:V833	43.8397	3.68	No	No	0	8	6
177	S:S:G830	S:S:Y829	44.0723	1.45	No	No	0	8	6
178	S:S:E755	S:S:Y829	44.3049	3.37	No	No	0	4	6
179	S:S:E755	S:S:F762	44.5248	7	No	Yes	50	4	7
180	S:S:F605	S:S:F762	47.5572	8.57	No	Yes	0	7	7
181	S:S:F605	S:S:I603	47.7893	33.91	No	No	0	7	4
182	S:S:E759	S:S:I603	48.0213	5.47	No	No	0	4	4
183	S:S:D758	S:S:E759	48.2533	6.5	No	No	0	4	4
184	S:S:D758	S:S:W590	48.4852	15.63	No	No	0	4	6
185	S:S:F98	S:S:R96	10.7595	5.34	Yes	Yes	0	4	4
186	S:S:F160	S:S:V115	32.2592	13.11	Yes	No	0	7	5
187	S:S:I162	S:S:V115	31.9099	3.07	Yes	No	0	6	5
188	S:S:I162	S:S:P163	39.2752	3.39	Yes	Yes	0	6	8
189	S:S:L464	S:S:P163	32.9465	3.28	No	Yes	0	7	8
190	S:S:L184	S:S:L464	31.5412	5.54	No	No	0	6	7
191	S:S:F479	S:S:L184	30.8389	6.09	No	No	0	8	6
192	S:S:F469	S:S:H429	11.1508	21.5	No	No	0	8	6
193	S:S:F160	S:S:N118	34.7215	4.83	Yes	No	0	7	4
194	S:S:I162	S:S:N118	31.9275	5.66	Yes	No	0	6	4
195	S:S:F479	S:S:L485	22.4596	6.09	No	No	0	8	4
196	S:S:L485	S:S:V477	21.7567	5.96	No	No	0	4	6
197	S:S:F114	S:S:F98	15.1455	7.5	Yes	Yes	0	5	4
198	S:S:R66	S:S:R69	10.498	3.2	Yes	No	0	5	8
199	S:S:I162	S:S:L157	23.3572	5.71	Yes	Yes	0	6	7
200	S:S:F239	S:S:V258	14.4889	3.93	Yes	No	0	6	4
201	S:S:H254	S:S:V258	14.2737	4.15	No	No	0	3	4
202	S:S:E241	S:S:H254	14.0586	6.15	No	No	0	5	3
203	S:S:E241	S:S:V255	13.8433	5.7	No	Yes	0	5	5
204	S:S:L279	S:S:V255	11.6893	4.47	No	Yes	0	5	5
205	S:S:I283	S:S:L279	11.4737	4.28	Yes	No	0	4	5
206	S:S:N471	S:S:V477	14.7991	5.91	Yes	No	0	6	6
207	S:S:V833	S:S:Y825	42.909	3.79	No	Yes	0	6	9
208	S:S:F821	S:S:Y825	41.9778	8.25	Yes	Yes	0	9	9
209	S:S:E837	S:S:F821	18.7353	4.66	No	Yes	0	9	9
210	S:S:E837	S:S:I841	12.8221	4.1	No	No	0	9	9
211	S:S:I841	S:S:S665	12.3482	3.1	No	No	0	9	8
212	S:S:L842	S:S:S665	12.1118	4.5	Yes	No	0	9	8
213	S:S:F662	S:S:L842	11.4027	3.65	Yes	Yes	0	8	9
214	S:S:F821	S:S:W818	22.5096	9.02	Yes	Yes	0	9	9
215	R:R:L112	R:R:L156	28.4652	2.77	Yes	No	0	5	5
216	R:R:L112	S:S:L156	28.4652	2.77	Yes	No	0	5	5
217	R:R:F160	S:S:L112	62.3828	2.44	Yes	Yes	0	7	5
218	R:R:L156	S:S:L112	28.4654	2.77	No	Yes	0	5	5
219	S:S:L112	S:S:L156	28.4654	2.77	Yes	No	0	5	5
220	S:S:R66	X:X:W1101	12.6612	3	Yes	Yes	0	5	0
221	R:R:R66	W:W:W1101	12.6612	3	Yes	Yes	0	5	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:F42	S:S:R62	8.55	44	Yes	No	3	4	1	2
S:S:F42	S:S:N64	13.29	44	Yes	Yes	3	4	1	2
S:S:F42	S:S:P274	7.22	44	Yes	Yes	3	3	1	2
S:S:F42	S:S:L304	10.96	44	Yes	No	3	2	1	2
M:M:?1102	S:S:F42	4.47	0	No	Yes	0	3	0	1
S:S:L304	S:S:P274	3.28	44	No	Yes	2	3	2	2
M:M:?1102	S:S:S302	5.51	0	No	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
100.00	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
100.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
100.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
100.00	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
100.00	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
100.00	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
100.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
100.00	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
100.00	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
100.00	Single	7DD5	Ca3	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
100.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
100.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
100.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
100.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
100.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00	Single	7EB2	Baclofen	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
100.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
100.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
100.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
100.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
100.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
100.00	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00	Single	7FII	hCG	7FII-LH-hCG-6fuf
100.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
100.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
100.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
100.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
100.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
100.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
100.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
100.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
100.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
100.00	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
100.00	Single	7XW7	K1-70	7XW7-TSH-K1-70
100.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
100.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
100.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
100.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
100.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
100.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
100.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
100.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
100.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
100.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
100.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
100.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
100.00	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-J9R
100.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
100.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
100.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
100.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
100.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
100.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
100.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
100.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
100.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
100.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
100.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
100.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
100.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
100.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
100.00	Consensus	fsh_on_allo	Orthosteric Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
100.00	Consensus	gabab_off	Orthosteric Ligand	7C7S-GABA_B1, GABA_B2-CGP54626 7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid 6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
100.00	Consensus	gabab_on	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
100.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
100.00	Consensus	gi_gaba	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	gphr_on	Orthosteric Ligand	lh_on tsh_on
100.00	Consensus	gs_gphr	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00	Consensus	gs_protein	Orthosteric Ligand	gs_gphr
100.00	Consensus	lh_on	Orthosteric Ligand	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00	Consensus	lh_on_allo	Orthosteric Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
100.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
100.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
100.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
100.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
100.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
100.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
100.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
100.00	Consensus	smo_off_allo	Other Ligand	6D32-SMO-Cyclopamine-Cyclopamine
100.00	Consensus	tsh_on	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2
100.00	Consensus	tsh_on_allo	Orthosteric Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
50.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
33.33	Single	8HS2	Fab046	8HS2-GPR20-Fab046
25.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
25.00	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00	Single	7UTZ	TR1402	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
25.00	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
25.00	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
20.00	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
20.00	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/&β;1/&γ;2
20.00	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
20.00	Single	8I2G	Glycoprotein hormones alpha chain	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
14.29	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
14.29	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
14.29	Single	6LI0	GTPL9804	6LI0-GPR52-GTPL9804
14.29	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
14.29	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
14.29	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
12.50	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
12.50	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
12.50	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
12.50	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50	Consensus	go_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.50	Consensus	go_protein	Orthosteric Ligand	go_chemokine
12.50	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
11.11	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
11.11	Single	5U09	Taranabant	5U09-CB₁-Taranabant
11.11	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.11	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
11.11	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
11.11	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
11.11	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
11.11	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
11.11	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
11.11	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
11.11	Single	8HMP	PubChem 69921479	8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Consensus	class-f_off	Orthosteric Ligand	smo_off
11.11	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
11.11	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
11.11	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
10.00	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
10.00	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
10.00	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.00	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
10.00	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
10.00	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
10.00	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
10.00	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
10.00	Consensus	gi_class-f	Orthosteric Ligand	gi_frizzled
10.00	Consensus	gi_frizzled	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
10.00	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
10.00	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
9.09	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
9.09	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
9.09	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
9.09	Single	6D27	CAY10471	6D27-DP₂-CAY10471
9.09	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.09	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
9.09	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
9.09	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
9.09	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
9.09	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
9.09	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
9.09	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
9.09	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
9.09	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.09	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
9.09	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
9.09	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.33	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
8.33	Single	5C1M	BU72	5C1M-μ-BU72
8.33	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.33	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.33	Single	7C4S	S1P	7C4S-S1P₃-S1P
8.33	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
8.33	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
8.33	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.33	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
8.33	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
8.33	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
8.33	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.69	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
7.69	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
7.69	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
7.69	Single	5V56	TC114	5V56-SMO-TC114
7.69	Single	5V57	TC114	5V57-SMO-TC114
7.69	Single	6OS1	TRV026	6OS1-AT₁-TRV026
7.69	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
7.69	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.69	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
7.69	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
7.69	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.69	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.69	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.69	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
7.69	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
7.69	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
7.69	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Single	8E0G	BU72	8E0G-μ-BU72
7.69	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
7.69	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
7.69	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.69	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
7.69	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
7.69	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
7.69	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.69	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
7.14	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
7.14	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
7.14	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
7.14	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
7.14	Single	6OS2	TRV026	6OS2-AT₁-TRV026
7.14	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.14	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
7.14	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
7.14	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.14	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
7.14	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
7.14	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.14	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
7.14	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
7.14	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
7.14	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
7.14	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
7.14	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
7.14	Consensus	dp_off	Orthosteric Ligand	dp2_off
7.14	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
7.14	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
7.14	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.14	Consensus	nts_on	Orthosteric Ligand	nts1_on
7.14	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
7.14	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.67	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
6.67	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
6.67	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
6.67	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
6.67	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
6.67	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
6.67	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6.67	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
6.67	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
6.67	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
6.67	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.67	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.67	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
6.25	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
6.25	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
6.25	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
6.25	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
6.25	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
6.25	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
6.25	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
6.25	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
6.25	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
6.25	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
6.25	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
6.25	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
5.88	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
5.88	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.88	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.88	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
5.88	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
5.88	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
5.88	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.88	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
5.88	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.88	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.88	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.88	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
5.88	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.88	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.88	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.88	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
5.88	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
5.56	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
5.56	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.56	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
5.56	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
5.56	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
5.56	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
5.56	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
5.56	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.56	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
5.56	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.56	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.56	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
5.56	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
5.26	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
5.26	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
5.26	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
5.26	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
5.26	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
5.26	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.26	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
5.26	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
5.26	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.26	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
5.26	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
5.26	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
5.26	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
5.26	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
5.00	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
5.00	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
5.00	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
5.00	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
5.00	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.00	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
5.00	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
5.00	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
5.00	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
5.00	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
5.00	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
5.00	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
5.00	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
5.00	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.00	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
5.00	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
5.00	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.76	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.76	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
4.76	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.76	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.76	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.76	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.76	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.76	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.76	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.76	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.76	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
4.76	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
4.76	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.76	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
4.76	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
4.55	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
4.55	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
4.55	Single	6FJ3	PTH	6FJ3-PTH1-PTH
4.55	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.55	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.55	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
4.55	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
4.55	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
4.55	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.55	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
4.55	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
4.55	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.55	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.55	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
4.55	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.55	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.35	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
4.35	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
4.35	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
4.35	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.35	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
4.35	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
4.35	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
4.35	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.35	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.35	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.35	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
4.35	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.35	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
4.35	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
4.35	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.35	Consensus	go_class-b1	Orthosteric Ligand	go_crf
4.35	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.35	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.17	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
4.17	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
4.17	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.17	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
4.17	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.17	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
4.17	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.17	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
4.17	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
4.17	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
4.17	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
4.17	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
4.17	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
4.17	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.17	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.17	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.17	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
4.17	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
4.17	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
4.17	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.00	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
4.00	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.00	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
4.00	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
4.00	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.00	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
4.00	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.00	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
4.00	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
4.00	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.00	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
4.00	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.00	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
3.85	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.85	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
3.85	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.85	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.85	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.85	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.85	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
3.85	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
3.70	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
3.70	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.70	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.70	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.70	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.70	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
3.57	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.57	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.57	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.57	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.57	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.57	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.57	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.57	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.57	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
3.57	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.45	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.45	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.45	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
3.45	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
3.33	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.33	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.23	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.23	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
3.23	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.12	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
3.12	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
3.12	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.03	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
3.03	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
3.03	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.94	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.94	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.86	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:N64	S:S:P39	3.26	0	Yes	Yes	4	6	2	2
S:S:P39	S:S:W70	5.4	2	Yes	Yes	6	5	2	2
S:S:P39	S:S:T145	8.74	2	Yes	Yes	6	5	2	1
S:S:N64	S:S:R66	3.62	0	Yes	Yes	4	5	2	1
S:S:R66	S:S:R69	3.2	0	Yes	No	5	8	1	2
S:S:R66	S:S:W70	11	0	Yes	Yes	5	5	1	2
S:S:R66	X:X:W1101	3	0	Yes	Yes	5	0	1	0
S:S:T145	S:S:W70	3.64	2	Yes	Yes	5	5	1	2
S:S:W70	S:S:Y167	4.82	2	Yes	Yes	5	8	2	2
S:S:I416	S:S:W70	11.74	0	No	Yes	4	5	1	2
S:S:G146	S:S:T145	3.64	0	No	Yes	5	5	2	1
S:S:T145	S:S:Y167	4.99	2	Yes	Yes	5	8	1	2
S:S:A168	S:S:T145	3.36	2	No	Yes	5	5	1	1
S:S:T145	X:X:W1101	3.64	2	Yes	Yes	5	0	1	0
S:S:A168	X:X:W1101	3.89	2	No	Yes	5	0	1	0
S:S:E297	S:S:Q193	5.1	0	No	Yes	8	9	1	2
S:S:A298	S:S:Y218	4	0	No	Yes	6	7	1	2
S:S:E297	S:S:L322	13.25	0	No	No	8	4	1	2
S:S:E297	X:X:W1101	6.54	0	No	Yes	8	0	1	0
S:S:A298	X:X:W1101	6.48	0	No	Yes	6	0	1	0
S:S:I416	X:X:W1101	3.52	0	No	Yes	4	0	1	0
S:S:R66	S:S:S301	1.32	0	Yes	No	5	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
100.00	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
100.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
100.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
100.00	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
100.00	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
100.00	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
100.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
100.00	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
100.00	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
100.00	Single	7DD5	Ca3	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
100.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
100.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
100.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
100.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
100.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00	Single	7EB2	Baclofen	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
100.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
100.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
100.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
100.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
100.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
100.00	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00	Single	7FII	hCG	7FII-LH-hCG-6fuf
100.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
100.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
100.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
100.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
100.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
100.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
100.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
100.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
100.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
100.00	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
100.00	Single	7XW7	K1-70	7XW7-TSH-K1-70
100.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
100.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
100.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
100.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
100.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
100.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
100.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
100.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
100.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
100.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
100.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
100.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
100.00	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-J9R
100.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
100.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
100.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
100.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
100.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
100.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
100.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
100.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
100.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
100.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
100.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
100.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
100.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
100.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
100.00	Consensus	fsh_on_allo	Orthosteric Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
100.00	Consensus	gabab_off	Orthosteric Ligand	7C7S-GABA_B1, GABA_B2-CGP54626 7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid 6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
100.00	Consensus	gabab_on	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
100.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
100.00	Consensus	gi_gaba	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	gphr_on	Orthosteric Ligand	lh_on tsh_on
100.00	Consensus	gs_gphr	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00	Consensus	gs_protein	Orthosteric Ligand	gs_gphr
100.00	Consensus	lh_on	Orthosteric Ligand	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00	Consensus	lh_on_allo	Orthosteric Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
100.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
100.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
100.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
100.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
100.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
100.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
100.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
100.00	Consensus	smo_off_allo	Other Ligand	6D32-SMO-Cyclopamine-Cyclopamine
100.00	Consensus	tsh_on	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2
100.00	Consensus	tsh_on_allo	Orthosteric Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
50.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
33.33	Single	8HS2	Fab046	8HS2-GPR20-Fab046
25.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
25.00	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00	Single	7UTZ	TR1402	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
25.00	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
25.00	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
20.00	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
20.00	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/&β;1/&γ;2
20.00	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
20.00	Single	8I2G	Glycoprotein hormones alpha chain	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
14.29	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
14.29	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
14.29	Single	6LI0	GTPL9804	6LI0-GPR52-GTPL9804
14.29	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
14.29	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
14.29	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
12.50	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
12.50	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
12.50	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
12.50	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50	Consensus	go_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.50	Consensus	go_protein	Orthosteric Ligand	go_chemokine
12.50	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
11.11	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
11.11	Single	5U09	Taranabant	5U09-CB₁-Taranabant
11.11	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.11	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
11.11	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
11.11	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
11.11	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
11.11	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
11.11	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
11.11	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
11.11	Single	8HMP	PubChem 69921479	8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Consensus	class-f_off	Orthosteric Ligand	smo_off
11.11	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
11.11	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
11.11	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
10.00	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
10.00	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
10.00	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.00	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
10.00	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
10.00	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
10.00	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
10.00	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
10.00	Consensus	gi_class-f	Orthosteric Ligand	gi_frizzled
10.00	Consensus	gi_frizzled	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
10.00	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
10.00	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
9.09	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
9.09	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
9.09	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
9.09	Single	6D27	CAY10471	6D27-DP₂-CAY10471
9.09	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.09	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
9.09	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
9.09	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
9.09	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
9.09	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
9.09	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
9.09	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
9.09	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
9.09	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.09	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
9.09	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
9.09	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.33	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
8.33	Single	5C1M	BU72	5C1M-μ-BU72
8.33	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.33	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.33	Single	7C4S	S1P	7C4S-S1P₃-S1P
8.33	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
8.33	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
8.33	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.33	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
8.33	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
8.33	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
8.33	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.69	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
7.69	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
7.69	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
7.69	Single	5V56	TC114	5V56-SMO-TC114
7.69	Single	5V57	TC114	5V57-SMO-TC114
7.69	Single	6OS1	TRV026	6OS1-AT₁-TRV026
7.69	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
7.69	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.69	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
7.69	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
7.69	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.69	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.69	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.69	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
7.69	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
7.69	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
7.69	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Single	8E0G	BU72	8E0G-μ-BU72
7.69	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
7.69	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
7.69	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.69	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
7.69	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
7.69	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
7.69	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.69	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
7.14	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
7.14	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
7.14	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
7.14	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
7.14	Single	6OS2	TRV026	6OS2-AT₁-TRV026
7.14	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.14	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
7.14	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
7.14	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.14	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
7.14	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
7.14	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.14	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
7.14	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
7.14	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
7.14	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
7.14	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
7.14	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
7.14	Consensus	dp_off	Orthosteric Ligand	dp2_off
7.14	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
7.14	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
7.14	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.14	Consensus	nts_on	Orthosteric Ligand	nts1_on
7.14	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
7.14	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.67	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
6.67	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
6.67	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
6.67	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
6.67	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
6.67	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
6.67	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6.67	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
6.67	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
6.67	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
6.67	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.67	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.67	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
6.25	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
6.25	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
6.25	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
6.25	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
6.25	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
6.25	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
6.25	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
6.25	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
6.25	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
6.25	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
6.25	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
6.25	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
5.88	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
5.88	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.88	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.88	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
5.88	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
5.88	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
5.88	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.88	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
5.88	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.88	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.88	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.88	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
5.88	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.88	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.88	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.88	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
5.88	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
5.56	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
5.56	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.56	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
5.56	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
5.56	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
5.56	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
5.56	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
5.56	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.56	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
5.56	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.56	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.56	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
5.56	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
5.26	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
5.26	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
5.26	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
5.26	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
5.26	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
5.26	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.26	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
5.26	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
5.26	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.26	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
5.26	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
5.26	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
5.26	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
5.26	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
5.00	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
5.00	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
5.00	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
5.00	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
5.00	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.00	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
5.00	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
5.00	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
5.00	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
5.00	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
5.00	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
5.00	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
5.00	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
5.00	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.00	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
5.00	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
5.00	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.76	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.76	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
4.76	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.76	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.76	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.76	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.76	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.76	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.76	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.76	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.76	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
4.76	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
4.76	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.76	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
4.76	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
4.55	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
4.55	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
4.55	Single	6FJ3	PTH	6FJ3-PTH1-PTH
4.55	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.55	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.55	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
4.55	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
4.55	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
4.55	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.55	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
4.55	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
4.55	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.55	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.55	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
4.55	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.55	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.35	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
4.35	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
4.35	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
4.35	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.35	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
4.35	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
4.35	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
4.35	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.35	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.35	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.35	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
4.35	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.35	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
4.35	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
4.35	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.35	Consensus	go_class-b1	Orthosteric Ligand	go_crf
4.35	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.35	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.17	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
4.17	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
4.17	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.17	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
4.17	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.17	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
4.17	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.17	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
4.17	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
4.17	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
4.17	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
4.17	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
4.17	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
4.17	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.17	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.17	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.17	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
4.17	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
4.17	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
4.17	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.00	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
4.00	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.00	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
4.00	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
4.00	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.00	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
4.00	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.00	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
4.00	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
4.00	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.00	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
4.00	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.00	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
3.85	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.85	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
3.85	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.85	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.85	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.85	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.85	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
3.85	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
3.70	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
3.70	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.70	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.70	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.70	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.70	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
3.57	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.57	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.57	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.57	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.57	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.57	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.57	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.57	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.57	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
3.57	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.45	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.45	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.45	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
3.45	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
3.33	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.33	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.23	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.23	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
3.23	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.12	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
3.12	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
3.12	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.03	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
3.03	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
3.03	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.94	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.94	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.86	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F42	R:R:R62	8.55	32	Yes	No	3	4	1	2
R:R:F42	R:R:N64	13.29	32	Yes	Yes	3	4	1	2
R:R:F42	R:R:P274	7.22	32	Yes	Yes	3	3	1	2
R:R:F42	R:R:L304	10.96	32	Yes	No	3	2	1	2
L:L:?1102	R:R:F42	4.47	0	No	Yes	0	3	0	1
R:R:L304	R:R:P274	3.28	32	No	Yes	2	3	2	2
L:L:?1102	R:R:S302	5.51	0	No	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
100.00	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
100.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
100.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
100.00	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
100.00	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
100.00	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
100.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
100.00	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
100.00	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
100.00	Single	7DD5	Ca3	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
100.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
100.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
100.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
100.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
100.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00	Single	7EB2	Baclofen	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
100.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
100.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
100.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
100.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
100.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
100.00	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00	Single	7FII	hCG	7FII-LH-hCG-6fuf
100.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
100.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
100.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
100.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
100.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
100.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
100.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
100.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
100.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
100.00	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
100.00	Single	7XW7	K1-70	7XW7-TSH-K1-70
100.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
100.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
100.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
100.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
100.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
100.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
100.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
100.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
100.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
100.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
100.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
100.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
100.00	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-J9R
100.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
100.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
100.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
100.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
100.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
100.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
100.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
100.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
100.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
100.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
100.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
100.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
100.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
100.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
100.00	Consensus	fsh_on_allo	Orthosteric Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
100.00	Consensus	gabab_off	Orthosteric Ligand	7C7S-GABA_B1, GABA_B2-CGP54626 7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid 6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
100.00	Consensus	gabab_on	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
100.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
100.00	Consensus	gi_gaba	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	gphr_on	Orthosteric Ligand	lh_on tsh_on
100.00	Consensus	gs_gphr	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00	Consensus	gs_protein	Orthosteric Ligand	gs_gphr
100.00	Consensus	lh_on	Orthosteric Ligand	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00	Consensus	lh_on_allo	Orthosteric Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
100.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
100.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
100.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
100.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
100.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
100.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
100.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
100.00	Consensus	smo_off_allo	Other Ligand	6D32-SMO-Cyclopamine-Cyclopamine
100.00	Consensus	tsh_on	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2
100.00	Consensus	tsh_on_allo	Orthosteric Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
50.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
33.33	Single	8HS2	Fab046	8HS2-GPR20-Fab046
25.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
25.00	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00	Single	7UTZ	TR1402	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
25.00	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
25.00	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
20.00	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
20.00	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/&β;1/&γ;2
20.00	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
20.00	Single	8I2G	Glycoprotein hormones alpha chain	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
14.29	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
14.29	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
14.29	Single	6LI0	GTPL9804	6LI0-GPR52-GTPL9804
14.29	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
14.29	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
14.29	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
12.50	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
12.50	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
12.50	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
12.50	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50	Consensus	go_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.50	Consensus	go_protein	Orthosteric Ligand	go_chemokine
12.50	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
11.11	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
11.11	Single	5U09	Taranabant	5U09-CB₁-Taranabant
11.11	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.11	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
11.11	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
11.11	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
11.11	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
11.11	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
11.11	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
11.11	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
11.11	Single	8HMP	PubChem 69921479	8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Consensus	class-f_off	Orthosteric Ligand	smo_off
11.11	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
11.11	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
11.11	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
10.00	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
10.00	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
10.00	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.00	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
10.00	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
10.00	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
10.00	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
10.00	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
10.00	Consensus	gi_class-f	Orthosteric Ligand	gi_frizzled
10.00	Consensus	gi_frizzled	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
10.00	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
10.00	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
9.09	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
9.09	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
9.09	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
9.09	Single	6D27	CAY10471	6D27-DP₂-CAY10471
9.09	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.09	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
9.09	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
9.09	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
9.09	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
9.09	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
9.09	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
9.09	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
9.09	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
9.09	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.09	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
9.09	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
9.09	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.33	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
8.33	Single	5C1M	BU72	5C1M-μ-BU72
8.33	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.33	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.33	Single	7C4S	S1P	7C4S-S1P₃-S1P
8.33	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
8.33	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
8.33	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.33	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
8.33	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
8.33	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
8.33	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.69	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
7.69	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
7.69	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
7.69	Single	5V56	TC114	5V56-SMO-TC114
7.69	Single	5V57	TC114	5V57-SMO-TC114
7.69	Single	6OS1	TRV026	6OS1-AT₁-TRV026
7.69	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
7.69	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.69	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
7.69	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
7.69	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.69	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.69	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.69	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
7.69	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
7.69	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
7.69	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Single	8E0G	BU72	8E0G-μ-BU72
7.69	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
7.69	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
7.69	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.69	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
7.69	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
7.69	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
7.69	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.69	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
7.14	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
7.14	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
7.14	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
7.14	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
7.14	Single	6OS2	TRV026	6OS2-AT₁-TRV026
7.14	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.14	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
7.14	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
7.14	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.14	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
7.14	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
7.14	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.14	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
7.14	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
7.14	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
7.14	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
7.14	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
7.14	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
7.14	Consensus	dp_off	Orthosteric Ligand	dp2_off
7.14	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
7.14	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
7.14	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.14	Consensus	nts_on	Orthosteric Ligand	nts1_on
7.14	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
7.14	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.67	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
6.67	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
6.67	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
6.67	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
6.67	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
6.67	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
6.67	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6.67	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
6.67	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
6.67	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
6.67	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.67	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.67	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
6.25	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
6.25	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
6.25	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
6.25	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
6.25	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
6.25	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
6.25	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
6.25	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
6.25	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
6.25	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
6.25	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
6.25	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
5.88	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
5.88	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.88	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.88	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
5.88	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
5.88	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
5.88	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.88	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
5.88	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.88	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.88	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.88	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
5.88	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.88	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.88	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.88	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
5.88	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
5.56	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
5.56	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.56	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
5.56	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
5.56	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
5.56	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
5.56	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
5.56	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.56	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
5.56	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.56	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.56	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
5.56	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
5.26	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
5.26	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
5.26	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
5.26	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
5.26	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
5.26	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.26	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
5.26	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
5.26	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.26	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
5.26	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
5.26	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
5.26	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
5.26	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
5.00	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
5.00	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
5.00	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
5.00	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
5.00	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.00	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
5.00	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
5.00	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
5.00	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
5.00	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
5.00	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
5.00	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
5.00	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
5.00	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.00	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
5.00	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
5.00	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.76	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.76	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
4.76	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.76	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.76	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.76	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.76	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.76	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.76	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.76	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.76	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
4.76	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
4.76	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.76	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
4.76	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
4.55	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
4.55	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
4.55	Single	6FJ3	PTH	6FJ3-PTH1-PTH
4.55	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.55	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.55	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
4.55	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
4.55	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
4.55	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.55	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
4.55	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
4.55	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.55	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.55	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
4.55	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.55	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.35	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
4.35	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
4.35	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
4.35	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.35	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
4.35	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
4.35	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
4.35	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.35	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.35	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.35	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
4.35	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.35	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
4.35	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
4.35	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.35	Consensus	go_class-b1	Orthosteric Ligand	go_crf
4.35	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.35	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.17	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
4.17	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
4.17	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.17	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
4.17	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.17	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
4.17	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.17	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
4.17	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
4.17	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
4.17	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
4.17	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
4.17	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
4.17	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.17	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.17	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.17	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
4.17	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
4.17	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
4.17	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.00	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
4.00	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.00	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
4.00	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
4.00	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.00	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
4.00	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.00	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
4.00	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
4.00	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.00	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
4.00	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.00	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
3.85	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.85	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
3.85	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.85	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.85	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.85	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.85	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
3.85	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
3.70	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
3.70	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.70	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.70	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.70	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.70	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
3.57	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.57	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.57	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.57	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.57	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.57	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.57	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.57	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.57	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
3.57	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.45	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.45	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.45	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
3.45	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
3.33	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.33	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.23	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.23	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
3.23	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.12	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
3.12	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
3.12	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.03	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
3.03	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
3.03	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.94	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.94	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.86	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N64	R:R:P39	3.26	0	Yes	Yes	4	6	2	2
R:R:P39	R:R:W70	5.4	1	Yes	Yes	6	5	2	2
R:R:P39	R:R:T145	8.74	1	Yes	Yes	6	5	2	1
R:R:N64	R:R:R66	3.62	0	Yes	Yes	4	5	2	1
R:R:R66	R:R:R69	3.2	0	Yes	No	5	8	1	2
R:R:R66	R:R:W70	11	0	Yes	Yes	5	5	1	2
R:R:R66	W:W:W1101	3	0	Yes	Yes	5	0	1	0
R:R:T145	R:R:W70	3.64	1	Yes	Yes	5	5	1	2
R:R:W70	R:R:Y167	4.82	1	Yes	Yes	5	8	2	2
R:R:I416	R:R:W70	11.74	0	No	Yes	4	5	1	2
R:R:G146	R:R:T145	3.64	0	No	Yes	5	5	2	1
R:R:T145	R:R:Y167	4.99	1	Yes	Yes	5	8	1	2
R:R:A168	R:R:T145	3.36	1	No	Yes	5	5	1	1
R:R:T145	W:W:W1101	3.64	1	Yes	Yes	5	0	1	0
R:R:A168	W:W:W1101	3.89	1	No	Yes	5	0	1	0
R:R:E297	R:R:Q193	5.1	0	No	Yes	8	9	1	2
R:R:A298	R:R:Y218	4	0	No	Yes	6	7	1	2
R:R:E297	R:R:L322	14.58	0	No	No	8	4	1	2
R:R:E297	W:W:W1101	6.54	0	No	Yes	8	0	1	0
R:R:A298	W:W:W1101	6.48	0	No	Yes	6	0	1	0
R:R:I416	W:W:W1101	3.52	0	No	Yes	4	0	1	0
R:R:R66	R:R:S301	1.32	0	Yes	No	5	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
100.00	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
100.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
100.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
100.00	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
100.00	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
100.00	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
100.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
100.00	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
100.00	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
100.00	Single	7DD5	Ca3	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
100.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
100.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
100.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
100.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
100.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00	Single	7EB2	Baclofen	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
100.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
100.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
100.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
100.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
100.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
100.00	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00	Single	7FII	hCG	7FII-LH-hCG-6fuf
100.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
100.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
100.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
100.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
100.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
100.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
100.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
100.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
100.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
100.00	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
100.00	Single	7XW7	K1-70	7XW7-TSH-K1-70
100.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
100.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
100.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
100.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
100.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
100.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
100.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
100.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
100.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
100.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
100.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
100.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
100.00	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-J9R
100.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
100.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
100.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
100.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
100.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
100.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
100.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
100.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
100.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
100.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
100.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
100.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
100.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
100.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
100.00	Consensus	fsh_on_allo	Orthosteric Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
100.00	Consensus	gabab_off	Orthosteric Ligand	7C7S-GABA_B1, GABA_B2-CGP54626 7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid 6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
100.00	Consensus	gabab_on	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
100.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
100.00	Consensus	gi_gaba	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	gphr_on	Orthosteric Ligand	lh_on tsh_on
100.00	Consensus	gs_gphr	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00	Consensus	gs_protein	Orthosteric Ligand	gs_gphr
100.00	Consensus	lh_on	Orthosteric Ligand	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00	Consensus	lh_on_allo	Orthosteric Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
100.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
100.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
100.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
100.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
100.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
100.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
100.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
100.00	Consensus	smo_off_allo	Other Ligand	6D32-SMO-Cyclopamine-Cyclopamine
100.00	Consensus	tsh_on	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2
100.00	Consensus	tsh_on_allo	Orthosteric Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
50.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
33.33	Single	8HS2	Fab046	8HS2-GPR20-Fab046
25.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
25.00	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00	Single	7UTZ	TR1402	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
25.00	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
25.00	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
20.00	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
20.00	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/&β;1/&γ;2
20.00	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
20.00	Single	8I2G	Glycoprotein hormones alpha chain	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
14.29	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
14.29	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
14.29	Single	6LI0	GTPL9804	6LI0-GPR52-GTPL9804
14.29	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
14.29	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
14.29	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
12.50	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
12.50	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
12.50	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
12.50	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50	Consensus	go_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.50	Consensus	go_protein	Orthosteric Ligand	go_chemokine
12.50	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
11.11	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
11.11	Single	5U09	Taranabant	5U09-CB₁-Taranabant
11.11	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.11	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
11.11	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
11.11	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
11.11	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
11.11	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
11.11	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
11.11	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
11.11	Single	8HMP	PubChem 69921479	8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Consensus	class-f_off	Orthosteric Ligand	smo_off
11.11	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
11.11	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
11.11	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
10.00	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
10.00	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
10.00	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.00	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
10.00	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
10.00	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
10.00	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
10.00	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
10.00	Consensus	gi_class-f	Orthosteric Ligand	gi_frizzled
10.00	Consensus	gi_frizzled	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
10.00	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
10.00	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
9.09	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
9.09	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
9.09	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
9.09	Single	6D27	CAY10471	6D27-DP₂-CAY10471
9.09	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.09	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
9.09	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
9.09	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
9.09	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
9.09	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
9.09	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
9.09	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
9.09	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
9.09	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.09	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
9.09	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
9.09	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.33	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
8.33	Single	5C1M	BU72	5C1M-μ-BU72
8.33	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.33	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.33	Single	7C4S	S1P	7C4S-S1P₃-S1P
8.33	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
8.33	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
8.33	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.33	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
8.33	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
8.33	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
8.33	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.69	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
7.69	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
7.69	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
7.69	Single	5V56	TC114	5V56-SMO-TC114
7.69	Single	5V57	TC114	5V57-SMO-TC114
7.69	Single	6OS1	TRV026	6OS1-AT₁-TRV026
7.69	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
7.69	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.69	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
7.69	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
7.69	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.69	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.69	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.69	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
7.69	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
7.69	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
7.69	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Single	8E0G	BU72	8E0G-μ-BU72
7.69	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
7.69	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
7.69	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.69	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
7.69	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
7.69	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
7.69	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.69	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
7.14	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
7.14	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
7.14	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
7.14	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
7.14	Single	6OS2	TRV026	6OS2-AT₁-TRV026
7.14	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.14	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
7.14	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
7.14	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.14	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
7.14	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
7.14	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.14	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
7.14	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
7.14	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
7.14	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
7.14	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
7.14	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
7.14	Consensus	dp_off	Orthosteric Ligand	dp2_off
7.14	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
7.14	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
7.14	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.14	Consensus	nts_on	Orthosteric Ligand	nts1_on
7.14	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
7.14	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.67	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
6.67	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
6.67	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
6.67	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
6.67	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
6.67	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
6.67	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6.67	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
6.67	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
6.67	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
6.67	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.67	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.67	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
6.25	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
6.25	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
6.25	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
6.25	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
6.25	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
6.25	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
6.25	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
6.25	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
6.25	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
6.25	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
6.25	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
6.25	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
5.88	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
5.88	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.88	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.88	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
5.88	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
5.88	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
5.88	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.88	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
5.88	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.88	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.88	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.88	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
5.88	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.88	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.88	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.88	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
5.88	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
5.56	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
5.56	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.56	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
5.56	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
5.56	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
5.56	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
5.56	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
5.56	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.56	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
5.56	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.56	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.56	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
5.56	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
5.26	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
5.26	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
5.26	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
5.26	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
5.26	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
5.26	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.26	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
5.26	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
5.26	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.26	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
5.26	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
5.26	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
5.26	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
5.26	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
5.00	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
5.00	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
5.00	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
5.00	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
5.00	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.00	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
5.00	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
5.00	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
5.00	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
5.00	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
5.00	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
5.00	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
5.00	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
5.00	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.00	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
5.00	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
5.00	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.76	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.76	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
4.76	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.76	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.76	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.76	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.76	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.76	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.76	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.76	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.76	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
4.76	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
4.76	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.76	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
4.76	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
4.55	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
4.55	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
4.55	Single	6FJ3	PTH	6FJ3-PTH1-PTH
4.55	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.55	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.55	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
4.55	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
4.55	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
4.55	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.55	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
4.55	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
4.55	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.55	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.55	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
4.55	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.55	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.35	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
4.35	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
4.35	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
4.35	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.35	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
4.35	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
4.35	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
4.35	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.35	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.35	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.35	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
4.35	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.35	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
4.35	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
4.35	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.35	Consensus	go_class-b1	Orthosteric Ligand	go_crf
4.35	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.35	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.17	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
4.17	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
4.17	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.17	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
4.17	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.17	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
4.17	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.17	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
4.17	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
4.17	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
4.17	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
4.17	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
4.17	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
4.17	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.17	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.17	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.17	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
4.17	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
4.17	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
4.17	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.00	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
4.00	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.00	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
4.00	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
4.00	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.00	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
4.00	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.00	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
4.00	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
4.00	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.00	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
4.00	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.00	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
3.85	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.85	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
3.85	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.85	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.85	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.85	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.85	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
3.85	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
3.70	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
3.70	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.70	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.70	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.70	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.70	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
3.57	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.57	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.57	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.57	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.57	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.57	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.57	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.57	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.57	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
3.57	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.45	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.45	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.45	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
3.45	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
3.33	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.33	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.23	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.23	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
3.23	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.12	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
3.12	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
3.12	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.03	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
3.03	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
3.03	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.94	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.94	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.86	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB	7DTV
Class	C
SubFamily	Ion
Type	Calcium-sensing
SubType	CaS
Species	Homo sapiens
Ligand	Ca
Other Ligand(s)	Ca; Tryptophan
Protein Partners	-
PDB Resolution	3.5
Date	2021-03-10
D.O.I.	10.1038/s41422-021-00474-0

Net Summary
I_min	2.98
Number of Linked Nodes	1496
Number of Links	1761
Number of Hubs	246
Number of Links mediated by Hubs	908
Number of Communities	50
Number of Nodes involved in Communities	376
Number of Links involved in Communities	540

Path Summary
Number Of Nodes in MetaPath	222
Number Of Links MetaPath	221
Number of Shortest Paths	15258916
Length Of Smallest Path	3
Average Path Length	43.5755
Length of Longest Path	82
Minimum Path Strength	1.185
Average Path Strength	6.28921
Maximum Path Strength	34.69
Minimum Path Correlation	0.7
Average Path Correlation	0.999495
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.43902
Average % Of Corr. Nodes	60.5463
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.9443
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CA
PDB Residues	L:L:?1102 W:W:?1103 X:X:?1108 M:M:?1102
Environment Details	Open EMBL-EBI Page
Code	CA
Name	CALCIUM ION
Synonyms
Identifier	calcium(+2) cation
Formula	Ca
Molecular Weight	40.078
SMILES	[Ca+2]
PubChem
Formal Charge	2
Total Atoms	1
Total Chiral Atoms	0
Total Bonds	0
Total Aromatic Bonds	0


Code	NAG
PDB Residues	H:H:?1 H:H:?2 H:H:?3 H:H:?4 H:H:?5 H:H:?6 H:H:?7 H:H:?8 H:H:?9 H:H:?10 H:H:?11 H:H:?12 H:H:?13 H:H:?14 H:H:?15 H:H:?16 H:H:?17 H:H:?18
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetyl-D-glucosamine
Identifier	N-[(2R,3R,4R,5S,6R)-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl]ethanamide
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES	CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41180
Sequence	>7DTV_Chain_R Y G P D Q R A Q K K G D I I L G G L F P I H F G V A A K D Q D L K S R P E S V E C I R Y N F R G F R W L Q A M I F A I E E I N S S P A L L P N L T L G Y R I F D T C N T V S K A L E A T L S F V A Q N K I D S L N L D E F C N C S E H I P S T I A V V G A T G S G V S T A V A N L L G L F Y I P Q V S Y A S S S R L L S N K N Q F K S F L R T I P N D E H Q A T A M A D I I E Y F R W N W V G T I A A D D D Y G R P G I E K F R E E A E E R D I C I D F S E L I S Q Y S D E E E I Q H V V E V I Q N S T A K V I V V F S S G P D L E P L I K E I V R R N I T G K I W L A S E A W A S S S L I A M P Q Y F H V V G G T I G F A L K A G Q I P G F R E F L K K V H P R K S V H N G F A K E F W E E T F N C H L Q E F R P L C T G D E N I S S V E T P Y I D Y T H L R I S Y N V Y L A V Y S I A H A L Q D I Y T C L P G R G L F T N G S C A D I K K V E A W Q V L K H L R H L N F T N N M G E Q V T F D E C G D L V G N Y S I I N W H L S P E D G S I V F K E V G Y Y N V Y A K K G E R L F I N E E K I L W S G F S R E V P F S N C S R D C L A G T R K G I I E G E P T C C F E C V E C P D G E Y S D E T D A S A C N K C P D D F W S N E N H T S C I A K E I E F L S W T E P F G I A L T L F A V L G I F L T A F V L G V F I K F E L S Y L L L F S L L C C F S S S L F F I G E P Q D W T C R L R Q P A F G I S F V L C I S C I L V K T N R Q F L L V F L C T F M Q I V I C V I W L Y T A P P S S Y R N Q E L E D E I I F I T C H E G S L M A L G F L I G Y T C L L A A I C F F F A F K S R K L P E N F N E A K F I T F S M L I F F I V W I S F I P A Y A S T Y G K F V S A V E V I A I L A A S F G L L A C I F F N K I Y I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	S
Protein	Receptor
UniProt	P41180
Sequence	>7DTV_Chain_S Y G P D Q R A Q K K G D I I L G G L F P I H F G V A A K D Q D L K S R P E S V E C I R Y N F R G F R W L Q A M I F A I E E I N S S P A L L P N L T L G Y R I F D T C N T V S K A L E A T L S F V A Q N K I D S L N L D E F C N C S E H I P S T I A V V G A T G S G V S T A V A N L L G L F Y I P Q V S Y A S S S R L L S N K N Q F K S F L R T I P N D E H Q A T A M A D I I E Y F R W N W V G T I A A D D D Y G R P G I E K F R E E A E E R D I C I D F S E L I S Q Y S D E E E I Q H V V E V I Q N S T A K V I V V F S S G P D L E P L I K E I V R R N I T G K I W L A S E A W A S S S L I A M P Q Y F H V V G G T I G F A L K A G Q I P G F R E F L K K V H P R K S V H N G F A K E F W E E T F N C H L Q E F R P L C T G D E N I S S V E T P Y I D Y T H L R I S Y N V Y L A V Y S I A H A L Q D I Y T C L P G R G L F T N G S C A D I K K V E A W Q V L K H L R H L N F T N N M G E Q V T F D E C G D L V G N Y S I I N W H L S P E D G S I V F K E V G Y Y N V Y A K K G E R L F I N E E K I L W S G F S R E V P F S N C S R D C L A G T R K G I I E G E P T C C F E C V E C P D G E Y S D E T D A S A C N K C P D D F W S N E N H T S C I A K E I E F L S W T E P F G I A L T L F A V L G I F L T A F V L G V F I K F E L S Y L L L F S L L C C F S S S L F F I G E P Q D W T C R L R Q P A F G I S F V L C I S C I L V K T N R Q F L L V F L C T F M Q I V I C V I W L Y T A P P S S Y R N Q E L E D E I I F I T C H E G S L M A L G F L I G Y T C L L A A I C F F F A F K S R K L P E N F N E A K F I T F S M L I F F I V W I S F I P A Y A S T Y G K F V S A V E V I A I L A A S F G L L A C I F F N K I Y I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7DD5	C	Ion	Calcium-sensing	CaS	Gallus gallus	Ca	Ca; Ca; Tryptophan; NPS-2143	-	3.2	2021-06-16	10.1126/sciadv.abg1483
	7DD6	C	Ion	Calcium-sensing	CaS	Gallus gallus	Ca	Ca; Ca; Tryptophan	-	3.2	2021-06-16	10.1126/sciadv.abg1483
	7DD7	C	Ion	Calcium-sensing	CaS	Gallus gallus	Ca	Ca; Ca; Tryptophan; Evocalcet	-	3.2	2021-06-16	10.1126/sciadv.abg1483
	7DTT	C	Ion	Calcium-sensing	CaS	Homo sapiens	Ca	Ca	-	3.8	2021-03-10	10.1038/s41422-021-00474-0
	7DTU	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Tryptophan	-	4.4	2021-03-10	10.1038/s41422-021-00474-0
	7DTV	C	Ion	Calcium-sensing	CaS	Homo sapiens	Ca	Ca; Tryptophan	-	3.5	2021-03-10	10.1038/s41422-021-00474-0
	7DTW	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	-	-	4.5	2021-03-10	10.1038/s41422-021-00474-0
	7E6T	C	Ion	Calcium-sensing	CaS	Homo sapiens	Ca	Ca; Ca; Cyclomethyltryptophan; PO4	-	3	2021-09-22	10.7554/eLife.68578
	7E6U	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	-	-	6	2021-09-22	10.7554/eLife.68578
	7M3E	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; NPS-2143; PO4	-	3.2	2021-06-30	10.1038/s41586-021-03691-0
	7M3F	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4	-	2.8	2021-06-30	10.1038/s41586-021-03691-0
	7M3G	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	-	2.5	2021-06-30	10.1038/s41586-021-03691-0
	7M3J	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	NPS-2143; PO4	-	4.1	2021-06-30	10.1038/s41586-021-03691-0
	7SIL	C	Ion	Calcium-sensing	CaS	Homo sapiens	Ca	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	-	2.7	2022-01-19	10.1073/pnas.2115849118
	7SIM	C	Ion	Calcium-sensing	CaS	Homo sapiens	Ca	Ca; Ca; Cyclomethyltryptophan; PO4	-	2.7	2022-01-19	10.1073/pnas.2115849118
	7SIN	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	NPS-2143	-	5.9	2022-01-19	10.1073/pnas.2115849118
	8SZF	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	-	2.8	2024-02-07	10.1038/s41586-024-07055-2
	8SZG	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	chim(NtGi1-Gq)/&β;1/&γ;2	3.6	2024-02-07	10.1038/s41586-024-07055-2
	8SZH	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	Gi1/&β;1/&γ;2	3.1	2024-02-07	10.1038/s41586-024-07055-2
	8SZI	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	Gi3/&β;1/&γ;2	3.5	2024-02-07	10.1038/s41586-024-07055-2
	8WPG	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Tryptophan; Cinacalcet; PO4; Ca	-	2.7	2023-11-22	10.1038/s41422-023-00892-2
	8WPU	C	Ion	Calcium-sensing	CaS	Homo sapiens	-	Tryptophan; Cinacalcet; PO4; Ca	chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2	3.1	2023-11-22	10.1038/s41422-023-00892-2
	9AXF	C	Ion	Calcium-sensing	CaS	Homo sapiens	Ca	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	chim(NtGi1-Gs-CtGq)/&β;1/&γ;2	3.5	2024-04-17	10.1038/s41586-024-07331-1
	9AYF	C	Ion	Calcium-sensing	CaS	Homo sapiens	Ca	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	Gi1/&β;1/&γ;2	3.6	2024-04-17	10.1038/s41586-024-07331-1

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