Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1NT.H18 8.1725448
2NT.Y19 8.9825419
31x46 4.5975407
41x50 5.9425429
51x57 4.49407
62x38 5.2375465
72x46 3.97429
82x57 8.88407
92x61 4.5825406
103x25 5.04571719
113x26 4.66415
123x28 8.1675415
133x29 7.6425415
143x33 5.545415
153x43 2.9475428
163x46 3.9875429
174x42 3.35506
184x56 1.315406
19E2.Y189 7615
205x39 7.11833617
215x58 5.845409
225x65 1.515408
236x52 5.9407
24E3.C282 4.2725434
257x31 3.8531
267x33 5.5775454
277x45 8.932529
287x49 3.5525429
297x50 3.636529
307x53 4.54429
31Lig 7.122311300
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1NT.H18 NT.L17 13.86289YesNo083
2E2.P187 NT.H18 23.1023.05NoYes048
3E2.P187 NT.Y19 24.936825.03NoYes049
43x25 NT.Y19 35.52963.86YesYes199
53x25 3x29 40.41433.27YesYes195
63x29 Lig 46.44879.65YesYes050
77x31 E3.R280 11.66922.43YesNo013
87x31 E3.C282 20.98184.76YesYes314
96x57 E3.C282 30.42493.17NoYes054
106x54 6x57 33.98034.15NoNo055
116x54 6x55 42.58342.77NoNo056
126x51 6x55 47.54955.54NoNo076
136x51 Lig 50.77886.42NoYes070
142x57 7x38 18.192915.24YesNo075
157x38 Lig 40.73237.33NoYes050
161x50 2x50 12.011710.77YesNo299
172x50 7x46 28.10088.83NoNo099
187x42 7x46 28.39447.67NoNo079
197x38 7x42 28.7452.83NoNo057
206x47 7x45 10.18516.3NoYes089
216x48 7x45 96.599518.08NoYes299
223x36 6x48 99.87776.83NoNo079
233x36 Lig 1007.33NoYes070
241x50 2x51 12.32165.49YesNo097
252x50 7x50 15.78733.22NoYes299
267x49 7x50 24.61063.26YesYes299
277x45 7x49 35.03225.45YesYes299
281x53 7x50 24.39865.3NoYes299
291x53 2x47 21.93591.59NoNo099
301x57 2x43 12.24821.38YesNo078
312x43 2x47 14.69462.95NoNo089
322x38 4x42 16.01575.25YesYes056
332x42 4x42 53.92642.95NoYes086
342x42 3x46 57.63685.71NoYes089
352x46 3x46 43.45592.85YesYes299
362x46 3x43 21.38952.77YesYes298
373x43 7x45 61.64892.75YesYes289
383x46 7x53 18.42943.63YesYes299
393x43 7x53 43.34993.52YesYes289
402x46 7x49 29.03862.75YesYes299
413x38 4x53 10.06283.42NoNo077
423x37 4x53 21.60973.2NoNo067
433x37 Lig 27.16310.74NoYes060
443x34 4x53 10.06283.23NoNo057
453x40 Lig 10.06287.89NoYes080
463x50 7x53 21.91966.17NoYes299
473x50 5x58 26.72275.14NoYes099
485x65 6x33 12.32981.49YesNo088
496x33 6x37 20.65562.77NoNo088
505x58 6x37 22.15618.21YesNo098
514x42 4x45 19.63633.01YesNo065
525x39 E2.W173 10.06286.75YesNo074
535x47 6x52 13.9779.65NoYes087
545x47 Lig 15.90964.84NoYes080
554x41 4x45 11.68561.24NoNo075
564x39 4x42 12.89242.59NoYes076
573x33 Lig 27.67687.26YesYes050
583x33 5x39 21.38959.28YesYes157
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
NT.K24NT.T2230NoNo6812
LigNT.K244.670YesNo0601
2x563x323.390NoNo5521
2x577x3815.240YesNo7521
2x603x283.620NoYes5512
2x60Lig11.820NoYes5010
3x253x2881YesYes9522
3x253x293.271YesYes9521
3x25E2.L1864.561YesNo9722
3x25E2.Y1895.791YesYes9522
3x29E2.L1865.31YesNo5712
3x29E2.Y18912.351YesYes5512
3x29Lig9.651YesYes5010
3x33E2.Y1894.131YesYes5512
3x335x399.281YesYes5712
3x33Lig7.261YesYes5010
3x366x486.830NoNo7912
3x36Lig7.330NoYes7010
3x374x533.20NoNo6712
3x37Lig10.740NoYes6010
3x405x503.070NoNo8812
3x40Lig7.890NoYes8010
E2.L186E2.Y1898.211NoYes7522
5x39E2.Y1895.961YesYes7522
5x43Lig11.560NoYes5010
5x476x529.650NoYes8712
5x47Lig4.840NoYes8010
6x516x555.540NoNo7612
6x51Lig6.420NoYes7010
7x387x422.830NoNo5712
7x38Lig7.330NoYes5010
7x34Lig2.090NoYes4010
6x517x411.580NoNo7712
3x334x571.511YesNo5812
3x373x411.470NoNo6512
3x32Lig0.990NoYes5010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
68.75Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
64.71Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
63.16Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
62.50Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
62.50Single8E0GBU728E0G-μ-BU72
60.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
58.82Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
58.82Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
58.82Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
57.14Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
56.25Single5C1MBU725C1M-μ-BU72
56.25Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
56.25Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
56.25Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
55.56Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
55.56Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
53.33Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
53.33Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
52.94Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
52.63Consensuslpl_onOrthosteric Ligands1p_on lpa_on
50.00Single7DFPSpiperone7DFP-D2-Spiperone
50.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
50.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
50.00Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
50.00Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
50.00Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
50.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
50.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
50.00Single7YITNalfurafine7YIT-κ-Nalfurafine
50.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
50.00Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
47.37Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
47.37Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
47.37Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
47.37Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
47.37Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
47.37Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
47.37Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
47.37Consensusorexin_onOrthosteric Ligandox2_on
47.06Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
47.06Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
47.06Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
47.06Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
47.06Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
47.06Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
46.67Single6AKXA4R6AKX-CCR5-A4R
46.67Single6AKYMaraviroc6AKY-CCR5-Maraviroc
46.67Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
46.67Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
46.67Consensusorexin_offOrthosteric Ligandox2_off ox1_off
45.45Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
45.45Consensusangiotensin_onOrthosteric Ligandat1_on
45.45Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
45.45Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
45.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
45.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
45.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
45.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
45.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
45.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
44.44Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
44.44Single4RWADIPP-NH24RWA-δ-DIPP-NH2
44.44Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
44.44Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
44.44Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
44.44Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
44.44Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
44.44Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
44.44Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
44.44Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
44.44Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
44.44Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
43.75Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
43.75Single4MBSMaraviroc4MBS-CCR5-Maraviroc
43.75Single4ZJCSB-6740424ZJC-OX1-SB-674042
43.75Single6TPGEMPA6TPG-OX2-EMPA
43.75Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
43.75Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
43.75Single8GGTEpinephrine8GGT-β2-Epinephrine
43.75Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
43.75Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75Consensus5ht5_onOrthosteric Ligand5ht5a_on
43.75Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
43.75Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
43.75Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
43.75Consensuss1p_offOrthosteric Ligands1p1_off
43.48Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
43.48Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
42.86Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
42.86Single8GGREpinephrine8GGR-β2-Epinephrine
42.11Single6A93Risperidone6A93-5-HT2A-Risperidone
42.11Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
42.11Single6ZG4HTL00099366ZG4-M1-HTL0009936
42.11Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
42.11Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.11Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.11Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
42.11Single8WU1KCA8WU1-CB1-KCA-Arrestin1
42.11Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
42.11Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
42.11Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
42.11Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
42.11Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
42.11Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
42.11Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
42.11Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
42.11Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
42.11Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
41.67Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
41.18Single2Y04Salbutamol2Y04-β1-Salbutamol
41.18Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
41.18Single6DRXLisuride6DRX-5-HT2B-Lisuride
41.18Single6TOTLemborexant6TOT-OX1-Lemborexant
41.18Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
41.18Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
41.18Single7UL4Alvimopan7UL4-μ-Alvimopan
41.18Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
41.18Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
41.18Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
41.18Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
41.18Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
41.18Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
41.18Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
41.18Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
41.18Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
41.18Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
41.18Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
40.91Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
40.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
40.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
40.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
40.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
40.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
40.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
40.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
40.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
40.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
40.00Single7SRQLSD7SRQ-5-HT2B-LSD
40.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
40.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
40.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
40.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
40.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
40.00Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
40.00Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8GGSEpinephrine8GGS-β2-Epinephrine
40.00Single8GH1Epinephrine8GH1-β2-Epinephrine
40.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
40.00Consensusendothelin_offOrthosteric Ligandetb_off
40.00Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
39.13Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
39.13Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
39.13Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
39.13Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
38.89Single2Y03Isoprenaline2Y03-β1-Isoprenaline
38.89Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
38.89Single5WQCEMPA5WQC-OX2-EMPA
38.89Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
38.89Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
38.89Single6TP6Filorexant6TP6-OX1-Filorexant
38.89Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
38.89Single7C4SS1P7C4S-S1P3-S1P
38.89Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
38.89Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
38.89Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
38.89Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
38.89Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
38.89Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
38.89Single7XKAEpinephrine7XKA-β2-Epinephrine
38.89Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
38.89Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single8EA0Iperoxo8EA0-M3-Iperoxo
38.89Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
38.89Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
38.89Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
38.89Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
38.89Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
38.10Single5ZTYAM102575ZTY-CB2-AM10257
38.10Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
38.10Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
38.10Single7SK9CCX6627SK9-ACKR3-CCX662
38.10Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
38.10Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
38.10Single8X5YAstemizole8X5Y-H1-Astemizole
38.10Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
38.10Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
37.50Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
37.50Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
37.50Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
37.50Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
37.50Single5WS3EMPA5WS3-OX2-EMPA
37.50Single6B73PubChem 1319551386B73-κ-PubChem 131955138
37.50Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
37.50Single6TODEMPA6TOD-OX1-EMPA-Na
37.50Single7C61Ergotamine7C61-5-HT1B-Ergotamine
37.50Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
37.50Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
37.50Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
37.50Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
37.50Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
37.50Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
37.50Single7XRRLemborexant7XRR-OX2-Lemborexant
37.50Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
37.50Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
37.50Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
37.50Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8GGVEpinephrine8GGV-β2-Epinephrine
37.50Single8GGWEpinephrine8GGW-β2-Epinephrine
37.50Single8GGXEpinephrine8GGX-β2-Epinephrine
37.50Single8GH0Epinephrine8GH0-β2-Epinephrine
37.50Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
37.50Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Consensusalpha1_onOrthosteric Ligandalpha1a_on
37.50Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
37.04Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
37.04Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
36.84Single3P0GBI1671073P0G-β2-BI167107
36.84Single4DJHJDTic4DJH-κ-JDTic
36.84Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
36.84Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
36.84Single4U15Tiotropium4U15-M3-Tiotropium
36.84Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
36.84Single5V54Methiothepin5V54-5-HT1B-Methiothepin
36.84Single5X93K-87945X93-ETB-K-8794
36.84Single5XR8AM8415XR8-CB1-AM841
36.84Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
36.84Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
36.84Single6H7JIsoprenaline6H7J-β1-Isoprenaline
36.84Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
36.84Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
36.84Single6OL9Tiotropium6OL9-M5-Tiotropium
36.84Single6TQ7SB-3348676TQ7-OX1-SB-334867
36.84Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
36.84Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
36.84Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
36.84Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
36.84Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
36.84Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
36.84Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
36.84Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
36.84Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
36.84Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
36.84Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
36.84Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
36.84Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
36.84Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
36.84Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
36.84Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
36.84Consensus5ht1_offOrthosteric Ligand5ht1b_off
36.84Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
36.84Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
36.84Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
36.84Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
36.84Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
36.84Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
36.84Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
36.84Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
36.84Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
36.84Consensushistamine_offOrthosteric Ligandh1_off
36.84Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
36.84Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
36.84Consensuslpa_offOrthosteric Ligandlpa1_off
36.84Consensuslpa_onOrthosteric Ligandlpa1_on
36.84Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
36.84Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
36.84Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
36.36Single4IARErgotamine4IAR-5-HT1B-Ergotamine
36.36Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
36.36Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
36.36Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
36.36Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
36.36Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
36.36Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
36.36Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
36.36Consensussst_onOrthosteric Ligandsst2_on sst4_on
35.71Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.71Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
35.29Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
35.29Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
35.29Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
35.29Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
35.29Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
35.29Single6PS4ICI 118-5516PS4-β2-ICI 118-551
35.29Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
35.29Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
35.29Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
35.29Single6TPNHTL66416TPN-OX2-HTL6641
35.29Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
35.29Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
35.29Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
35.29Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
35.29Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
35.29Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
35.29Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
35.29Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
35.29Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
35.29Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
35.29Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
35.29Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
35.29Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
35.29Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
35.29Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
35.29Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
35.29Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
35.29Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
35.29Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8GGIEpinephrine8GGI-β2-Epinephrine
35.29Single8GGKEpinephrine8GGK-β2-Epinephrine
35.29Single8GGMEpinephrine8GGM-β2-Epinephrine
35.29Single8GGPEpinephrine8GGP-β2-Epinephrine
35.29Single8GGQEpinephrine8GGQ-β2-Epinephrine
35.29Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
35.29Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
35.29Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
35.29Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
35.29Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
35.29Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
35.29Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
35.29Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
35.00Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
35.00Single4LDEBI1671074LDE-β2-BI167107
35.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
35.00Single5CXVTiotropium5CXV-M1-Tiotropium
35.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
35.00Single6CM4Risperidone6CM4-D2-Risperidone
35.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
35.00Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
35.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
35.00Single6MXTSalmeterol6MXT-β2-Salmeterol
35.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
35.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
35.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
35.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
35.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
35.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
35.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
35.00Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
35.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
35.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
35.00Single8JJ8Formoterol8JJ8-β2-Formoterol
35.00Single8JJLOlodaterol8JJL-β2-Olodaterol
35.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
35.00Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
35.00Consensusdp_offOrthosteric Liganddp2_off
35.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
35.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
34.78Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
34.78Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
34.78Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
34.78Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
34.78Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
34.78Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
34.62Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
34.48Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
33.33Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
33.33Single3NY8ICI 118-5513NY8-β2-ICI 118-551
33.33Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
33.33Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
33.33Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
33.33Single4EJ4Naltrindole4EJ4-δ-Naltrindole
33.33Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
33.33Single4MQSIperoxo4MQS-M2-Iperoxo
33.33Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
33.33Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
33.33Single4U14Tiotropium4U14-M3-Tiotropium
33.33Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
33.33Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
33.33Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
33.33Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
33.33Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
33.33Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
33.33Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
33.33Single6H7MSalbutamol6H7M-β1-Salbutamol
33.33Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
33.33Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
33.33Single6PS1Timolol6PS1-β2-Timolol
33.33Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
33.33Single6PT2KGCHM076PT2-δ-KGCHM07
33.33Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
33.33Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
33.33Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
33.33Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
33.33Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
33.33Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
33.33Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
33.33Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
33.33Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
33.33Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
33.33Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
33.33Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
33.33Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
33.33Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
33.33Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
33.33Single7UM4AS26747237UM4-5-HT5A-AS2674723
33.33Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
33.33Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
33.33Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
33.33Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
33.33Single7WC7Lisuride7WC7-5-HT2A-Lisuride
33.33Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
33.33Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
33.33Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
33.33Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
33.33Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
33.33Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
33.33Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
33.33Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
33.33Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
33.33Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
33.33Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GGJEpinephrine8GGJ-β2-Epinephrine
33.33Single8GGNEpinephrine8GGN-β2-Epinephrine
33.33Single8GGOEpinephrine8GGO-β2-Epinephrine
33.33Single8GGUEpinephrine8GGU-β2-Epinephrine
33.33Single8GGZEpinephrine8GGZ-β2-Epinephrine
33.33Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
33.33Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
33.33Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
33.33Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
33.33Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
33.33Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
33.33Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
33.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
33.33Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
33.33Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
33.33Single8X63Mepyramine8X63-H1-Mepyramine
33.33Single8X64Desloratadine8X64-H1-Desloratadine
33.33Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
33.33Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
33.33Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
33.33Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
33.33Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
33.33Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
33.33Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
33.33Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
33.33Consensusblt_onOrthosteric Ligandblt1_on
33.33Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
33.33Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
33.33Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
33.33Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Consensusgi_hcarOrthosteric Ligandgi_hca
33.33Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
33.33Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
33.33Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
33.33Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
33.33Consensusleuko_onOrthosteric Ligandblt_on
33.33Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
33.33Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
33.33Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
33.33Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
33.33Consensussteroid_onOrthosteric Ligandbileacid_on
33.33Consensustar_onOrthosteric Ligandta1_on
32.26Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
32.14Single6IGLIRL16206IGL-ETB-IRL1620
32.14Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
32.14Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
32.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
32.00Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
32.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
32.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
32.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
32.00Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Single3NY9PubChem 9131033NY9-β2-PubChem 913103
31.82Single4UG2CGS216804UG2-A2A-CGS21680
31.82Single6PT3DPI-2876PT3-δ-DPI-287
31.82Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.82Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
31.82Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
31.82Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
31.82Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
31.82Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
31.82Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
31.82Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
31.82Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
31.58Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
31.58Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
31.58Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
31.58Single5TVNLSD5TVN-5-HT2B-LSD
31.58Single5WIUNemonapride5WIU-D4-Nemonapride
31.58Single5WIVNemonapride5WIV-D4-Nemonapride-Na
31.58Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
31.58Single5XPRBosentan5XPR-ETB-Bosentan
31.58Single6E67BI1671076E67-β2-BI167107-Gs (fused)
31.58Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
31.58Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
31.58Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
31.58Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
31.58Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
31.58Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
31.58Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
31.58Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
31.58Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
31.58Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
31.58Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
31.58Single7WC6LSD7WC6-5-HT2A-LSD
31.58Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
31.58Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
31.58Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
31.58Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
31.58Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
31.58Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
31.58Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
31.58Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
31.58Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
31.58Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
31.58Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
31.58Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
31.58Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
31.58Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
31.58Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
31.58Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
31.58Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
31.58Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
31.58Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
31.58Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
31.58Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
31.58Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
31.58Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
31.58Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
31.58Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
31.58Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
31.25Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
31.25Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
31.25Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
31.25Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
31.25Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
31.25Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
31.25Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
31.25Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25Single8GGYEpinephrine8GGY-β2-Epinephrine
31.25Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
31.25Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
31.25Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
31.25Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
31.25Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
31.25Consensuspth_onOrthosteric Ligandpth1_on pth2_on
31.03Single5GLHEndothelin-15GLH-ETB-Endothelin-1
31.03Single6IGKEndothelin-36IGK-ETB-Endothelin-3
30.77Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
30.77Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
30.77Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
30.77Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
30.77Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single4XT1Fractalkine4XT1-US28-Fractalkine
30.43Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
30.43Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
30.43Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
30.43Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
30.43Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
30.43Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
30.43Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
30.00Single2YDVNECA2YDV-A2A-NECA
30.00Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
30.00Single4UHRCGS216804UHR-A2A-CGS21680
30.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
30.00Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
30.00Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
30.00Single5G53NECA5G53-A2A-NECA-Gs
30.00Single5XRAAM115425XRA-CB1-AM11542
30.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
30.00Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
30.00Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
30.00Single6WGTLSD6WGT-5-HT2A-LSD
30.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
30.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
30.00Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
30.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
30.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
30.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
30.00Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
30.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
30.00Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
30.00Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
30.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
30.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
30.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
30.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
30.00Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
30.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
30.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
30.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
30.00Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
30.00Consensus5ht5_offOrthosteric Ligand5ht5a_off
30.00Consensusa2_onOrthosteric Liganda2a_on a2b_on
30.00Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
30.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
30.00Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
30.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
30.00Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
30.00Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
30.00Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
30.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
30.00Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
29.63Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
29.63Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
29.63Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
29.63Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
29.63Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
29.63Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
29.63Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
29.63Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single4S0VSuvorexant4S0V-OX2-Suvorexant
29.41Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
29.41Single6KUXRS-799486KUX-α2a-RS-79948
29.41Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
29.41Single6TPJSuvorexant6TPJ-OX2-Suvorexant
29.41Single7BR3Elagolix7BR3-GnRH1-Elagolix
29.41Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
29.41Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
29.41Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
29.41Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
29.41Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
29.41Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
29.41Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
29.41Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
29.41Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
29.41Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
29.41Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
29.41Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
29.41Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
29.41Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
29.41Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
29.41Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
29.41Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
29.41Single8IHKAcifran8IHK-HCA3-Acifran
29.41Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single8IWESpermidine8IWE-TAAR9-Spermidine
29.41Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
29.41Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
29.41Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
29.41Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
29.41Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
29.41Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
29.41Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
29.41Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
29.41Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
29.41Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
29.41Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
29.41Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
29.41Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
29.41Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
29.17Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
29.17Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
29.17Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
29.17Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
29.17Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
29.17Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
29.17Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
29.17Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
29.17Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
29.03Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
29.03Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
28.57Single4AMIBucindolol4AMI-β1-Bucindolol
28.57Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
28.57Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
28.57Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
28.57Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
28.57Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
28.57Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
28.57Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
28.57Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
28.57Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
28.57Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
28.57Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
28.57Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
28.57Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
28.57Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
28.57Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
28.57Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
28.57Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
28.57Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
28.57Consensusgo_class-b1Orthosteric Ligandgo_crf
28.57Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
28.57Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
28.57Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
28.57Consensusgs_steroidOrthosteric Ligandgs_bileacid
28.57Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
28.57Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
28.57Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
28.12Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
28.12Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
28.00Single5WF5UK-4320975WF5-A2A-UK-432097
28.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
28.00Single6W25SHU91196W25-MC4-SHU9119-Ca
28.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
28.00Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
28.00Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
28.00Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
28.00Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Single3RZECidoxepin3RZE-H1-Cidoxepin
27.78Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
27.78Single6A94Zotepine6A94-5-HT2A-Zotepine
27.78Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
27.78Single6IQLL7458706IQL-D4-L745870
27.78Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
27.78Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
27.78Single6TP3Nemorexant6TP3-OX1-Nemorexant
27.78Single6V9SGTPL114036V9S-OX1-GTPL11403
27.78Single6VI4JDTic6VI4-κ-JDTic
27.78Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
27.78Single6ZG9GSK10347026ZG9-M1-GSK1034702
27.78Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
27.78Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
27.78Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
27.78Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
27.78Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
27.78Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
27.78Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
27.78Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
27.78Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
27.78Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8GGLEpinephrine8GGL-β2-Epinephrine
27.78Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
27.78Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
27.78Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
27.78Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
27.78Single8K5CAcipimox8K5C-HCA2-Acipimox
27.78Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
27.78Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
27.78Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
27.78Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
27.78Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
27.78Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
27.78Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
27.78Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
27.78Consensusgnrh_offOrthosteric Ligandgnrh1_off
27.78Consensushca_onOrthosteric Ligandhca2_on hca3_on
27.78Consensushcar_onOrthosteric Ligandhca_on
27.78Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
27.78Consensussensory_offOrthosteric Ligandopsin_off
27.59Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
27.59Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
27.59Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
27.59Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
27.59Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
27.59Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
27.59Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
27.27Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
27.27Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
27.27Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
27.27Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
27.27Single6H7LDobutamine6H7L-β1-Dobutamine
27.27Single6IBLArformoterol6IBL-β1-Arformoterol
27.27Single6K1QIRL25006K1Q-ETB-IRL2500
27.27Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
27.27Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
27.27Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
27.27Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
26.92Single6JODAngiotensin II6JOD-AT2-Angiotensin II
26.92Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
26.92Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
26.92Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
26.92Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
26.67Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
26.67Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
26.67Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single6TQ9SB-4081246TQ9-OX1-SB-408124
26.67Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
26.67Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
26.67Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
26.67Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
26.67Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
26.32Single2Y01Dobutamine2Y01-β1-Dobutamine
26.32Single2Y02Carmoterol2Y02-β1-Carmoterol
26.32Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
26.32Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
26.32Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
26.32Single4DAJTiotropium4DAJ-M3-Tiotropium
26.32Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
26.32Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
26.32Single4YAYZD-71554YAY-AT1-ZD-7155
26.32Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
26.32Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
26.32Single5TGZAM65385TGZ-CB1-AM6538
26.32Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
26.32Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
26.32Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
26.32Single6D27CAY104716D27-DP2-CAY10471
26.32Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
26.32Single6GPSMK08126GPS-CCR2-MK0812
26.32Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
26.32Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
26.32Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
26.32Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
26.32Single7BU7BI1671077BU7-β1-BI167107
26.32Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
26.32Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
26.32Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
26.32Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
26.32Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
26.32Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
26.32Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
26.32Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
26.32Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
26.32Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
26.32Single8JJOAlprenolol8JJO-β2-Alprenolol
26.32Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
26.32Single8K5DGSK2560738K5D-HCA2-GSK256073
26.32Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
26.32Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
26.32Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
26.32Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
26.32Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
26.32Consensusadenosine_onOrthosteric Liganda1_on a2_on
26.32Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
26.32Consensuscck_offOrthosteric Ligandccka_off
26.32Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
26.32Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
26.32Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
26.32Consensushistamine_onOrthosteric Ligandh1_on h4_on
26.32Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
26.32Consensusnucleotide_onOrthosteric Ligandadenosine_on
26.32Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
26.09Single5EE7MK08935EE7-Glucagon-MK0893
26.09Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
26.09Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
26.09Single7XN9L-054,5227XN9-SST2-L-054,522
26.09Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
26.09Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
26.09Consensusclass-d_offOrthosteric Ligandste2_off
26.09Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
25.93Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
25.93Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
25.93Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
25.93Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
25.93Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
25.93Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
25.93Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
25.93Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.81Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
25.00Single2Y00Dobutamine2Y00-β1-Dobutamine
25.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
25.00Single3OE6IT1t3OE6-CXCR4-IT1t
25.00Single3OE8IT1t3OE8-CXCR4-IT1t
25.00Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
25.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
25.00Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
25.00Single4XT3Fractalkine4XT3-US28-Fractalkine
25.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
25.00Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
25.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
25.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
25.00Single6GPXMK08126GPX-CCR2-MK0812
25.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
25.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
25.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
25.00Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
25.00Single6PS6Timolol6PS6-β2-Timolol
25.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
25.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
25.00Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
25.00Single7QA8Peptide7QA8-STE2-Peptide
25.00Single7QA8Peptide7QA8-STE2-Peptide
25.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
25.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
25.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
25.00Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
25.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
25.00Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
25.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
25.00Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
25.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
25.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
25.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
25.00Consensusclass-d_offOrthosteric Ligandste2_off
25.00Consensusclass-d_onOrthosteric Ligandste2_on
25.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
25.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
25.00Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
25.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
25.00Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
25.00Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
25.00Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
25.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
25.00Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
25.00Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
25.00Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
25.00Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
25.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
24.24Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
24.24Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
24.24Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
24.24Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
24.24Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
24.14Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
24.14Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
24.14Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
24.14Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
24.14Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
24.14Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
24.14Consensusendothelin_onOrthosteric Ligandetb_on eta_on
24.14Consensusgi_class-dOrthosteric Ligandgi_ste
24.14Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
24.14Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
24.00Single3QAKUK-4320973QAK-A2A-UK-432097
24.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
24.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
24.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
24.00Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
23.81Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
23.81Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
23.81Single5TZR-5TZR-FFA1 (GPR40)-MK8666
23.81Single6E59L-7607356E59-NK1-L-760735
23.81Single6J20Aprepitant6J20-NK1-Aprepitant
23.81Single6J21Aprepitant6J21-NK1-Aprepitant
23.81Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
23.81Single7EPENAM5637EPE-mGlu-NAM563
23.81Single7TUYGSK682753A7TUY-GPR183-GSK682753A
23.81Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
23.81Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
23.81Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
23.81Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
23.81Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
23.81Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
23.81Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
23.81Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
23.81Consensuscck_onOrthosteric Ligandccka_on cckb_on
23.81Consensuschemerin_onOrthosteric Ligandcml1_on
23.81Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
23.81Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
23.81Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
23.81Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
23.81Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
23.81Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
23.68Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
23.68Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
23.53Single3OE9IT1t3OE9-CXCR4-IT1t
23.53Single3PBLEticlopride3PBL-D3-Eticlopride
23.53Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
23.53Single6HLLCP999946HLL-NK1-CP99994
23.53Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
23.53Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
23.53Single6TP4ACT-4622066TP4-OX1-ACT-462206
23.53Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
23.53Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
23.53Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
23.53Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
23.53Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
23.53Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
23.53Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
23.53Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
23.53Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
23.53Single8K5BNiacin8K5B-HCA2-Niacin
23.53Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
23.53Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
23.53Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
23.53Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
23.53Consensusclass-t_onOrthosteric Ligandtaste2_on
23.53Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
23.53Consensusgs_class-tOrthosteric Ligandgs_taste
23.53Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
23.53Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
23.53Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
23.33Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
23.33Single6LMLGlucagon6LML-Glucagon-Glucagon
23.33Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
23.33Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
23.33Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
23.33Single8IY6Endothelin-18IY6-ETB-Endothelin-1
23.33Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
23.33Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.33Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
23.08Single3OE0CVX153OE0-CXCR4-CVX15
23.08Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
23.08Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
23.08Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
23.08Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
23.08Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
23.08Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
23.08Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
22.73Single4N4WSANT-14N4W-SMO-SANT-1
22.73Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
22.73Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
22.73Single6HLPNetupitant6HLP-NK1-Netupitant
22.73Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
22.73Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
22.73Single7K15MKD0467K15-BLT1-MKD046-Na
22.73Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
22.73Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
22.73Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single8JWZAB9288JWZ-A2A-AB928-Na
22.73Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
22.73Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
22.73Consensusblt_offOrthosteric Ligandblt1_off
22.73Consensusgi_class-fOther Ligandgi_frizzled
22.73Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
22.58Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
22.58Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
22.58Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
22.22Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
22.22Single3ODUIT1t3ODU-CXCR4-IT1t
22.22Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
22.22Single5DHHSB-6121115DHH-NOP-SB-612111
22.22Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
22.22Single6ME2Ramelteon6ME2-MT1-Ramelteon
22.22Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
22.22Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
22.22Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
22.22Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
22.22Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
22.22Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
22.22Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
22.22Single7F8ULintitript7F8U-CCKA-Lintitript
22.22Single7F8YDevazepide7F8Y-CCKA-Devazepide
22.22Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
22.22Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
22.22Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
22.22Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
22.22Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
22.22Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
22.22Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
22.22Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
22.22Single8GNGIstradefylline8GNG-A2A-Istradefylline
22.22Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
22.22Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
22.22Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
22.22Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
22.22Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
22.22Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
22.22Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
22.22Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
22.22Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
22.22Consensusgt_class-aOrthosteric Ligandgt_opsin
22.22Consensusgt_opsinOrthosteric Ligandgt_sensory
22.22Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
22.22Consensusmglu_onOther Ligandmglu2_on mglu4_on
22.22Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
21.88Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
21.88Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
21.88Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
21.88Consensusglp_onOrthosteric Ligandglp1_on glp2_on
21.74Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
21.74Single5CGDHTL142425CGD-mGlu5-HTL14242
21.74Single7EZCUKA7EZC-A2A-UKA
21.74Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
21.74Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
21.74Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
21.74Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
21.43Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
21.43Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
21.43Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
21.43Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
21.43Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
21.43Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
21.43Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
21.43Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
21.43Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
21.43Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
21.43Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
21.43Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
21.21Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
21.21Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
21.05Single2YDOAdenosine2YDO-A2A-Adenosine
21.05Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
21.05Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
21.05Single6DS0Ly2660976DS0-5-HT2B-Ly266097
21.05Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
21.05Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
21.05Single6TPKRetosiban6TPK-OT-Retosiban
21.05Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
21.05Single7AROLUF58337ARO-A2A-LUF5833-Na
21.05Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
21.05Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
21.05Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
21.05Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single7T32ZM2413857T32-A2A-ZM241385
21.05Single7VODCariprazine7VOD-5-HT2A-Cariprazine
21.05Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
21.05Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
21.05Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
21.05Single8K2WAMG4878K2W-CXCR3-AMG487
21.05Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
21.05Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
21.05Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
21.05Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
21.05Consensusvasopressin-ot_offOrthosteric Ligandot_off
20.83Single5WF6UK-4320975WF6-A2A-UK-432097
20.83Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
20.83Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
20.83Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
20.83Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
20.83Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
20.83Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.83Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
20.69Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
20.69Single6FJ3PTH6FJ3-PTH1-PTH
20.69Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
20.69Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
20.69Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
20.69Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
20.69Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
20.69Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7SK3CXCL127SK3-ACKR3-CXCL12
20.69Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
20.69Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
20.59Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
20.00Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
20.00Single5DSGTiotropium5DSG-M4-Tiotropium
20.00Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
20.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
20.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
20.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
20.00Single5UENDU1725UEN-A1-DU172
20.00Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
20.00Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
20.00Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
20.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
20.00Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
20.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
20.00Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
20.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
20.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
20.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
20.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
20.00Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
20.00Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
20.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
20.00Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
20.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
20.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
20.00Single8CU6LJ-45178CU6-A2A-LJ-4517
20.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
20.00Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
20.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
20.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
20.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
20.00Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
20.00Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
20.00Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
20.00Consensushcar_offOrthosteric Ligandsuccinate_off
20.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
20.00Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
20.00Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
20.00Consensustachykinin_offOrthosteric Ligandnk1_off
19.35Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
19.35Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
19.35Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
19.35Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
19.35Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
19.35Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
19.23Single6HLOAprepitant6HLO-NK1-Aprepitant
19.23Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
19.23Single7SK5CXCL127SK5-ACKR3-CXCL12
19.23Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
19.23Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
19.23Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
19.23Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
19.05Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
19.05Single5CGCHTL142425CGC-mGlu5-HTL14242
19.05Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
19.05Single5N2SPSB365N2S-A1-PSB36
19.05Single5NM2ZM2413855NM2-A2A-ZM241385-Na
19.05Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
19.05Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
19.05Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
19.05Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
19.05Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
19.05Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
19.05Single7SINNPS-21437SIN-CaS-NPS-2143
19.05Single7SINNPS-21437SIN-CaS-NPS-2143
19.05Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
19.05Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
19.05Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
19.05Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
19.05Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
19.05Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
18.75Single3RFMCaffeine3RFM-A2A-Caffeine
18.75Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
18.75Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single8A2OTheophylline8A2O-A2A-Theophylline-Na
18.75Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
18.75Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
18.75Consensussensory_onOrthosteric Ligandopsin_on
18.52Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
18.52Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
18.52Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
18.52Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
18.42Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
18.18Single6OS1TRV0266OS1-AT1-TRV026
18.18Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
18.18Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
18.18Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
18.18Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
18.18Single7W41PD1762527W41-BB2-PD176252
18.18Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
18.18Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
18.18Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
18.18Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
18.18Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
18.18Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
18.18Consensusadenosine_offOrthosteric Liganda1_off a2_off
18.18Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
18.18Consensusbombesin_offOrthosteric Ligandbb2_off
18.18Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
18.18Consensusrelaxin_onOrthosteric Ligandrxfp4_on
17.86Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
17.86Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.86Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.86Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
17.86Consensusclass-d_onOrthosteric Ligandste2_on
17.86Consensusgi_class-dOrthosteric Ligandgi_ste
17.86Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.86Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
17.86Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
17.86Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.65Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
17.65Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
17.65Single6ME5Agomelatine6ME5-MT1-Agomelatine
17.65Single6ME9Ramelteon6ME9-MT2-Ramelteon
17.65Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
17.65Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
17.65Single7WC5Psilocin7WC5-5-HT2A-Psilocin
17.65Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
17.65Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Single4PY02MeSATP4PY0-P2Y12-2MeSATP
17.39Single5X33BIIL2605X33-BLT1-BIIL260
17.39Single6OS2TRV0266OS2-AT1-TRV026
17.39Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
17.39Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
17.39Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
17.39Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
17.39Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
17.39Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
17.39Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
17.39Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
17.39Consensuschemokine_offOrthosteric Ligandcxcr_off
17.39Consensusclass-b2_onOrthosteric Ligandadgrg_on
17.39Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
17.39Consensuscxcr_offOrthosteric Ligandcxcr4_off
17.39Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
17.24Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
17.24Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.24Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
17.14Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
16.67Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
16.67Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
16.67Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
16.67Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
16.67Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
16.67Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
16.67Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.67Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
16.67Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
16.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
16.67Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
16.67Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
16.67Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
16.67Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
16.67Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
16.67Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
16.67Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
16.67Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
16.67Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
16.67Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
16.67Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
16.67Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
16.67Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
16.13Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
16.13Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.13Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
16.13Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
16.13Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
16.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
16.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
16.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
16.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
16.00Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
16.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
16.00Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
15.79Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
15.79Single3PWHZM2413853PWH-A2A-ZM241385
15.79Single5K2DZM2413855K2D-A2A-ZM241385
15.79Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
15.79Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
15.79Single5U09Taranabant5U09-CB1-Taranabant
15.79Single5ZKQABT-4915ZKQ-PAF-ABT-491
15.79Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
15.79Single6JZHZM2413856JZH-A2A-ZM241385-Na
15.79Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
15.79Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
15.79Single6PS7ZM2413856PS7-A2A-ZM241385-Na
15.79Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
15.79Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
15.79Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
15.79Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
15.79Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
15.79Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
15.79Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
15.79Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
15.79Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
15.79Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
15.79Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
15.79Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
15.62Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
15.62Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
15.38Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
15.38Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
15.38Single7F8XNN90567F8X-CCKA-NN9056
15.38Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
15.38Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
15.15Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single3REYPubChem 56973REY-A2A-PubChem 5697
15.00Single5IU4ZM2413855IU4-A2A-ZM241385-Na
15.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
15.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
15.00Single5JTBZM2413855JTB-A2A-ZM241385
15.00Single5K2BZM2413855K2B-A2A-ZM241385-Na
15.00Single5K2CZM2413855K2C-A2A-ZM241385-Na
15.00Single5NLXZM2413855NLX-A2A-ZM241385-Na
15.00Single5NM4ZM2413855NM4-A2A-ZM241385-Na
15.00Single6AQFZM2413856AQF-A2A-ZM241385
15.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
15.00Single6MH8ZM2413856MH8-A2A-ZM241385
15.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
15.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
15.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
15.00Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
15.00Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
15.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
15.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
15.00Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
15.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
15.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
15.00Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
15.00Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
15.00Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
15.00Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
15.00Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
14.81Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
14.81Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
14.81Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
14.81Consensussst_offOrthosteric Ligandsst2_off
14.71Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
14.29Single3EMLZM2413853EML-A2A-ZM241385
14.29Single4EIYZM2413854EIY-A2A-ZM241385-Na
14.29Single5IU8Q274563475IU8-A2A-Q27456347-Na
14.29Single5K2AZM2413855K2A-A2A-ZM241385-Na
14.29Single5OLGZM2413855OLG-A2A-ZM241385-Na
14.29Single5VRAZM2413855VRA-A2A-ZM241385-Na
14.29Single6FFHFenobam6FFH-mGlu5-Fenobam
14.29Single6IIVDaltroban6IIV-TP-Daltroban
14.29Single6LPJZM2413856LPJ-A2A-ZM241385-Na
14.29Single6LPKZM2413856LPK-A2A-ZM241385-Na
14.29Single6S0LZM2413856S0L-A2A-ZM241385
14.29Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
14.29Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
14.29Single7PYRPSB-21157PYR-A2A-PSB-2115
14.29Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
14.29Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
14.29Single7XNACYN1548067XNA-SST2-CYN154806
14.29Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
14.29Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
14.29Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusa2_offOrthosteric Liganda2a_off
14.29Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
14.29Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
14.29Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
14.29Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
14.29Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
14.29Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
14.29Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
13.89Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
13.79Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
13.64Single5IUAQ274563485IUA-A2A-Q27456348-Na
13.64Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
13.64Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
13.64Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
13.64Single6LPLZM2413856LPL-A2A-ZM241385-Na
13.64Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
13.64Single6S0QZM2413856S0Q-A2A-ZM241385
13.64Single6WQAZM2413856WQA-A2A-ZM241385-Na
13.64Single7RM5ZM2413857RM5-A2A-ZM241385-Na
13.64Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
13.64Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
13.64Single8FYNZM2413858FYN-A2A-ZM241385-Na
13.64Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
13.64Single8GNEKW-63568GNE-A2A-KW-6356-Na
13.64Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
13.64Single8QOTNanobody E8QOT-μ-Nanobody E
13.64Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
13.64Consensusep_offOrthosteric Ligandep4_off
13.64Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.51Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
13.33Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
13.33Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
13.33Single5MZPCaffeine5MZP-A2A-Caffeine-Na
13.33Single6W25Ca6W25-MC4-SHU9119-Ca
13.33Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.33Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
13.16Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
13.04Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
13.04Single4BV0Neurotensin4BV0-NTS1-Neurotensin
13.04Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
13.04Single7F1TMIP-1a7F1T-CCR5-MIP-1a
13.04Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
13.04Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
13.04Single7P2L4YI7P2L-mGlu5-4YI
13.04Single7PX4PSB-21137PX4-A2A-PSB-2113
13.04Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
13.04Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
13.04Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
13.04Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
13.04Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
12.90Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
12.90Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
12.50Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
12.50Single4XEENeurotensin4XEE-NTS1-Neurotensin
12.50Single4XESNeurotensin4XES-NTS1-Neurotensin
12.50Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
12.50Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
12.50Single6IIURamatroban6IIU-TP-Ramatroban
12.50Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
12.50Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
12.50Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
12.50Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single6YVRNTS8-136YVR-NTS1-NTS8-13
12.50Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
12.50Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
12.50Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
12.50Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.50Single8PWNTheophylline8PWN-A2A-Theophylline
12.50Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
12.50Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
12.50Consensusclass-c_onOther Ligandgabab_on mglu_on
12.50Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
12.50Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
12.50Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
12.50Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
12.20Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
12.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
12.00Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
12.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
12.00Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
12.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
12.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
12.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
12.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
12.00Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
12.00Consensuscyslt_offOrthosteric Ligandcyslt2_off
12.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
12.00Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
11.76Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
11.54Single6KNMJN241-96KNM-Apelin-JN241-9
11.54Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
11.54Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Consensusgs_class-b2Orthosteric Ligandgs_adgr
11.11Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
11.11Single3UZAGTPL92363UZA-A2A-GTPL9236
11.11Single4XNWMRS25004XNW-P2Y1-MRS2500
11.11Single6LI0GTPL98046LI0-GPR52-GTPL9804
11.11Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
11.11Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
11.11Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
11.11Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
11.11Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
11.11Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
11.11Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
10.71Single7SHEPI; PE7SHE-GPR158-PI; PE
10.53Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
10.53Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.53Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
10.53Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
10.53Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.53Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.53Consensusgo_class-b2Orthosteric Ligandgo_adhesion
10.53Consensusgo_proteinOrthosteric Ligandgo_chemokine
10.53Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.34Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
10.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
10.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
10.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.00Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
10.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.00Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.52Single5UVIZM2413855UVI-A2A-ZM241385
9.52Single6ZINSR486926ZIN-NTS1-SR48692
9.52Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
9.52Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
9.52Single8IYXYL-3658IYX-GPR34-YL-365
9.52Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
9.38Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
9.09Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
9.09Single5T04Neurotensin5T04-NTS1-Neurotensin
9.09Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
9.09Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.09Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
9.09Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
9.09Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.82Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
8.70Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
8.70Single6Z4SSR486926Z4S-NTS1-SR48692
8.70Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
8.70Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
8.70Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
8.70Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
8.70Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
8.57Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
8.33Single5V56TC1145V56-SMO-TC114
8.33Single5V57TC1145V57-SMO-TC114
8.33Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
8.33Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
8.33Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
8.33Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.33Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.11Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
8.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
8.00Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
8.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
8.00Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
8.00Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
8.00Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
8.00Consensusnts_offOrthosteric Ligandnts1_off
8.00Consensusnts_onOrthosteric Ligandnts1_on
7.89Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
7.89Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
7.69Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
7.69Single6D35Cholesterol6D35-SMO-Cholesterol
7.69Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
7.69Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
7.69Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
7.69Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
7.69Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
7.69Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
7.69Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.69Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.69Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
7.69Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
7.69Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
7.69Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
7.69Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
7.69Single7DTTCa7DTT-CaS-Ca-Ca
7.69Single7DTTCa7DTT-CaS-Ca-Ca
7.69Single7DTUTryptophan7DTU-CaS-Tryptophan
7.69Single7DTUTryptophan7DTU-CaS-Tryptophan
7.69Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
7.69Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
7.69Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
7.69Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
7.69Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.69Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.69Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
7.69Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
7.69Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
7.69Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
7.69Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
7.69Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
7.69Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
7.69Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
7.69Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
7.69Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single7FIIhCG7FII-LH-hCG-6fuf
7.69Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
7.69Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
7.69Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.69Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.69Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.69Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.69Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.69Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.69Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
7.69Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
7.69Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
7.69Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
7.69Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
7.69Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
7.69Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
7.69Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.69Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.69Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.69Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.69Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
7.69Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
7.69Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
7.69Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
7.69Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
7.69Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
7.69Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
7.69Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
7.69Single7XW7K1-707XW7-TSH-K1-70
7.69Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
7.69Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
7.69Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
7.69Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
7.69Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
7.69Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
7.69Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
7.69Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
7.69Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
7.69Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
7.69Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
7.69Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
7.69Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
7.69Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
7.69Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
7.69Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
7.69Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
7.69Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
7.69Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
7.69Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
7.69Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
7.69Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
7.69Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
7.69Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.69Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.69Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
7.69Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
7.69Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
7.69Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
7.69Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.69Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.69Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
7.69Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
7.69Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
7.69Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
7.69Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
7.69Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
7.69Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.69Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.69Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
7.69Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
7.69Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
7.69Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
7.69Consensusclass-c_offOther Ligandgabab_off mglu_off
7.69Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
7.69Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
7.69Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
7.69Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
7.69Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
7.69Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
7.69Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
7.69Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
7.69Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.69Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.69Consensusgphr_onOrthosteric Ligandlh_on tsh_on
7.69Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
7.69Consensusgs_proteinOrthosteric Ligandgs_gphr
7.69Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
7.69Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
7.69Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
7.69Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.69Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.69Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
7.69Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
7.69Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.69Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.69Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
7.69Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
7.69Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
7.69Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
7.69Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
7.69Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
7.69Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
7.69Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
7.69Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.50Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
7.14Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
7.14Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
7.14Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
7.14Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
7.14Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
7.14Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
7.14Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
7.14Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
7.14Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
6.98Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
6.90Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
6.90Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
6.67Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
6.67Single8HS2Fab0468HS2-GPR20-Fab046
6.45Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
6.25Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
6.25Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
6.25Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
6.25Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.25Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
5.88Single5L7DCholesterol5L7D-SMO-Cholesterol
5.88Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
5.88Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
5.88Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
5.71Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
5.56Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.56Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.56Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
5.56Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
5.56Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
5.56Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.56Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
5.41Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.26Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.26Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
5.26Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
5.26Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
5.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
5.00Single5L7IVismodegib5L7I-SMO-Vismodegib
5.00Single7UL2SR486927UL2-NTS1-SR48692-Na
5.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
5.00Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
4.76Single4K5YCP-3763954K5Y-CRF1-CP-376395
4.76Single4QINSAG1.54QIN-SMO-SAG1.5
4.76Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
4.76Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.76Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
4.76Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
4.76Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
4.76Single8HNNSCH5467388HNN-CXCR3-SCH546738
4.76Consensusclass-f_offOrthosteric Ligandsmo_off
4.55Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.55Single7VV6C48/807VV6-MRGPRX2-C48/80
4.55Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.55Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
4.55Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
4.55Consensusgi_class-fOrthosteric Ligandgi_frizzled
4.55Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.55Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single4Z9GCP-3763954Z9G-CRF1-CP-376395
4.35Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
4.35Single8GTIBMK-C2058GTI-CRF1-BMK-C205
4.17Single8GTGBMK-I1528GTG-CRF1-BMK-I152
4.17Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
3.85Single7SHEPI; PE7SHE-GPR158-PI; PE
3.85Single8GTMBMK-C2038GTM-CRF1-BMK-C203

Consensus Members
Id Members
7EW1 7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
Net Summary
Imin 2.75
Number of Linked Nodes 228
Number of Links 248
Number of Hubs 31
Number of Links mediated by Hubs 118
Number of Communities 7
Number of Nodes involved in Communities 47
Number of Links involved in Communities 63
Path Summary
Number Of Nodes in MetaPath 59
Number Of Links MetaPath 58
Number of Shortest Paths 27232
Length Of Smallest Path 3
Average Path Length 11.3075
Length of Longest Path 24
Minimum Path Strength 1.13
Average Path Strength 5.83855
Maximum Path Strength 14.445
Minimum Path Correlation 0.7
Average Path Correlation 0.923616
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 5
Average % Of Corr. Nodes 54.9347
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.8292
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
s1p_ons1p3_on
s1p5_on
s1p1_on
s1p2_on



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