Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x60 5.405406
22x42 5.2575408
32x46 5.744519
42x50 6.994519
52x57 5.12427
6E1x50 6.07429767
73x32 7.745427
83x34 5.5675446
93x37 6.1475446
103x42 7.982518
113x43 6.9175418
123x44 4.14408
133x46 4.1625419
143x51 6.265408
153x52 7.375404
16I2x53 8.575477
174x58 7.924544
18E2.K174 3.52503
19E2x52 6.3825424
20E2.M187 7.15433
21E2.V188 4.8975424
225x36 5.8375404
235x39 5.93571727
245x47 9.34558
255x51 6.1475457
265x54 4.8775458
275x58 4.852559
285x62 4.1825406
296x44 5.3825459
306x48 8.88167608
316x52 9.4125407
326x55 6.94405
336x58 7.685433
34E3.Y287 7.4275433
35E3.V289 6.4075434
367x34 9.532534
377x37 6.4225406
387x39 9.48426
397x42 8.485627
407x43 2.2225405
417x45 10.13419
427x49 10.2325419
437x50 3.5125409
447x53 5.8675419
458x50 6.335408
46Lig 9.25125820
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
16x48 7x45 10014.69YesYes089
23x36 6x48 50.769410.92NoYes078
33x32 3x36 12.47144.34YesNo277
43x32 7x42 14.396910.34YesYes277
57x45 7x49 42.025812.26YesYes199
62x50 7x49 12.94128.08YesYes199
73x43 7x45 56.68634.12YesYes189
82x46 3x43 29.25875.54YesYes198
92x46 3x46 51.6854.28YesYes199
102x42 3x46 74.683.77YesYes089
112x42 3x49 62.45794.78YesNo088
122x39 3x49 32.08385.78NoNo788
132x37 2x39 31.05643.04NoNo058
142x37 2x40 29.45057.08NoNo059
152x40 I1x50 16.48858.24NoNo098
162x46 7x49 28.94889.61YesYes199
173x43 7x53 27.88947.03YesYes189
183x46 7x53 25.02924.84YesYes199
191x60 I1x50 11.5759.5YesNo068
203x49 I2x53 28.830510.34NoYes787
212x40 8x50 11.5754.83NoYes098
223x28 7x42 10.79375.14NoYes057
233x36 Lig 38.131817.1NoYes270
24E2x52 Lig 23.81646.05YesYes240
255x39 E2x52 20.2185.16YesYes274
265x39 E2.N162 11.19798.14YesNo075
276x48 6x52 50.40035.01YesYes087
286x52 Lig 44.26768.07YesYes070
295x461 Lig 19.8763.92NoYes050
303x37 5x461 18.91255.03YesNo065
313x37 4x53 11.0196.99YesNo468
323x34 4x53 10.12893.28YesNo468
336x44 6x48 23.57356.01YesYes098
345x54 6x44 26.40173.73YesYes589
355x54 5x58 18.7914.79YesYes589
36I2x53 I2x57 26.18448.38YesNo077
374x41 I2x57 24.5693.72NoNo067
383x52 4x41 22.94874.12YesNo046
393x52 3x56 14.80758.06YesNo047
403x51 3x56 13.16976.72YesNo087
416x51 Lig 21.96286.05NoYes060
426x51 7x34 21.46919.02NoYes064
436x58 7x34 28.77312.28YesYes334
446x58 E3.Y287 20.47366.9YesYes333
456x55 Lig 23.049410.24YesYes050
466x55 7x34 31.28335.65YesYes054
475x44 6x52 12.46195.28NoYes067
485x44 6x55 12.10555.96NoYes065
495x58 6x37 13.97984.69YesNo098
505x62 6x37 13.00193.52YesNo068
516x54 7x34 11.161212.13NoYes344
527x34 E3.V289 10.97588.58YesYes344
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x563x327.32NoYes7721
2x567x423.792NoYes7722
3x29E2x529.080NoYes4421
3x323x364.342YesNo7711
3x327x4210.342YesYes7712
3x32Lig92YesYes7010
3x33Lig13.580NoYes5010
3x366x4810.922NoYes7812
3x36Lig17.12NoYes7010
3x375x4615.034YesNo6521
E2.V188E2x525.242YesYes4421
5x39E2x525.162YesYes7421
E2x52Lig6.052YesYes4010
5x39E2.V1885.052YesYes7422
6x55E2.V1885.910YesYes5412
5x446x525.280NoYes6721
5x446x555.960NoYes6521
5x461Lig3.920NoYes5010
5x476x5219.295YesYes8721
6x486x525.010YesYes8721
6x517x349.020NoYes6412
6x517x387.310NoNo6512
6x51Lig6.050NoYes6010
6x52Lig8.070YesYes7010
6x557x345.650YesYes5412
6x55Lig10.240YesYes5010
7x387x4214.070NoYes5722

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
88.89Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
88.89Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
88.89Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
80.00Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
80.00Single8GGKEpinephrine8GGK-β2-Epinephrine
80.00Single8GGLEpinephrine8GGL-β2-Epinephrine
80.00Single8GGMEpinephrine8GGM-β2-Epinephrine
80.00Single8GGPEpinephrine8GGP-β2-Epinephrine
77.78Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
77.78Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
72.73Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
72.73Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
72.73Single6PS1Timolol6PS1-β2-Timolol
72.73Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
72.73Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
72.73Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
72.73Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
72.73Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
72.73Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GGJEpinephrine8GGJ-β2-Epinephrine
72.73Single8GGNEpinephrine8GGN-β2-Epinephrine
72.73Single8GGOEpinephrine8GGO-β2-Epinephrine
72.73Single8GGUEpinephrine8GGU-β2-Epinephrine
72.73Single8JJOAlprenolol8JJO-β2-Alprenolol
72.73Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
72.73Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
72.73Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
72.73Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
72.73Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
70.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
70.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
70.00Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
70.00Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
70.00Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
70.00Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
70.00Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
70.00Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
70.00Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
66.67Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
66.67Single6E67BI1671076E67-β2-BI167107-Gs (fused)
66.67Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
66.67Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
66.67Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
66.67Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
66.67Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
66.67Single7XKAEpinephrine7XKA-β2-Epinephrine
66.67Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
66.67Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
66.67Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
66.67Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
66.67Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
66.67Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
66.67Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
66.67Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
66.67Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
63.64Single3RZECidoxepin3RZE-H1-Cidoxepin
63.64Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
63.64Single6A94Zotepine6A94-5-HT2A-Zotepine
63.64Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
63.64Single6PS4ICI 118-5516PS4-β2-ICI 118-551
63.64Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
63.64Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
63.64Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
63.64Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
63.64Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
63.64Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
63.64Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
63.64Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
63.64Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8GGIEpinephrine8GGI-β2-Epinephrine
63.64Single8GGQEpinephrine8GGQ-β2-Epinephrine
63.64Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
63.64Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
63.64Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
63.64Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
63.64Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
63.64Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
63.64Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
61.54Single3P0GBI1671073P0G-β2-BI167107
61.54Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
61.54Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
61.54Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
61.54Single6H7JIsoprenaline6H7J-β1-Isoprenaline
61.54Single6J20Aprepitant6J20-NK1-Aprepitant
61.54Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
61.54Single6WGTLSD6WGT-5-HT2A-LSD
61.54Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
61.54Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
61.54Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
61.54Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
61.54Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
61.54Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
61.54Consensus5ht5_offOrthosteric Ligand5ht5a_off
61.54Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
61.54Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
61.54Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
61.54Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
61.54Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
60.00Single3PBLEticlopride3PBL-D3-Eticlopride
60.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
60.00Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
60.00Single7SRQLSD7SRQ-5-HT2B-LSD
60.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
60.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
60.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
60.00Single8GGSEpinephrine8GGS-β2-Epinephrine
60.00Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
60.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
60.00Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
60.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
60.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
58.33Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
58.33Single2Y02Carmoterol2Y02-β1-Carmoterol
58.33Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
58.33Single3NY8ICI 118-5513NY8-β2-ICI 118-551
58.33Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
58.33Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
58.33Single6H7MSalbutamol6H7M-β1-Salbutamol
58.33Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
58.33Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
58.33Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
58.33Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
58.33Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
58.33Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
58.33Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
58.33Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
58.33Single7WC7Lisuride7WC7-5-HT2A-Lisuride
58.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
58.33Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
58.33Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
58.33Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
58.33Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
58.33Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
58.33Single8X63Mepyramine8X63-H1-Mepyramine
58.33Single8X64Desloratadine8X64-H1-Desloratadine
58.33Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
58.33Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
58.33Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
58.33Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
58.33Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
58.33Consensustachykinin_offOrthosteric Ligandnk1_off
57.14Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
57.14Single4AMIBucindolol4AMI-β1-Bucindolol
57.14Single4LDEBI1671074LDE-β2-BI167107
57.14Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
57.14Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
57.14Single6MXTSalmeterol6MXT-β2-Salmeterol
57.14Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
57.14Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
57.14Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
57.14Single8JJ8Formoterol8JJ8-β2-Formoterol
57.14Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
54.55Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
54.55Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
54.55Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
54.55Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
54.55Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
54.55Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
54.55Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
54.55Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
54.55Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
54.55Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
54.55Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
54.55Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
54.55Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
54.55Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
54.55Single8GGVEpinephrine8GGV-β2-Epinephrine
54.55Single8GGWEpinephrine8GGW-β2-Epinephrine
54.55Single8GGXEpinephrine8GGX-β2-Epinephrine
54.55Single8GH0Epinephrine8GH0-β2-Epinephrine
54.55Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
54.55Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
54.55Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
54.55Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
54.55Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
54.55Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
54.55Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
54.55Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
54.55Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
53.85Single2Y03Isoprenaline2Y03-β1-Isoprenaline
53.85Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
53.85Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
53.85Single5TVNLSD5TVN-5-HT2B-LSD
53.85Single5WIUNemonapride5WIU-D4-Nemonapride
53.85Single5WIVNemonapride5WIV-D4-Nemonapride-Na
53.85Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
53.85Single6PS6Timolol6PS6-β2-Timolol
53.85Single7WC6LSD7WC6-5-HT2A-LSD
53.85Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
53.85Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
53.85Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
53.85Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
53.85Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
53.85Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
53.85Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
53.85Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
53.85Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
53.33Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
53.33Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
53.33Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
53.33Single6H7LDobutamine6H7L-β1-Dobutamine
53.33Single6IBLArformoterol6IBL-β1-Arformoterol
53.33Single7UM4AS26747237UM4-5-HT5A-AS2674723
53.33Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
53.33Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
50.00Single2YDVNECA2YDV-A2A-NECA
50.00Single3NY9PubChem 9131033NY9-β2-PubChem 913103
50.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
50.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
50.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
50.00Single4UHRCGS216804UHR-A2A-CGS21680
50.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
50.00Single5G53NECA5G53-A2A-NECA-Gs
50.00Single6E59L-7607356E59-NK1-L-760735
50.00Single6J21Aprepitant6J21-NK1-Aprepitant
50.00Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
50.00Single6TPNHTL66416TPN-OX2-HTL6641
50.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
50.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
50.00Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
50.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
50.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
50.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
50.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
50.00Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GGREpinephrine8GGR-β2-Epinephrine
50.00Single8GGTEpinephrine8GGT-β2-Epinephrine
50.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
50.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
50.00Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
50.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
50.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
50.00Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
50.00Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
50.00Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
50.00Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
50.00Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
50.00Consensushistamine_offOrthosteric Ligandh1_off
50.00Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
50.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
47.06Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
47.06Single4IARErgotamine4IAR-5-HT1B-Ergotamine
47.06Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
46.67Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
46.67Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
46.67Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
46.67Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
46.67Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
46.67Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
46.67Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
46.67Single8JJLOlodaterol8JJL-β2-Olodaterol
46.67Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
46.67Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
46.67Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
46.67Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
46.15Single2Y04Salbutamol2Y04-β1-Salbutamol
46.15Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
46.15Single4DAJTiotropium4DAJ-M3-Tiotropium
46.15Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
46.15Single4MQSIperoxo4MQS-M2-Iperoxo
46.15Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
46.15Single4U14Tiotropium4U14-M3-Tiotropium
46.15Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
46.15Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
46.15Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
46.15Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
46.15Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
46.15Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
46.15Single7BU7BI1671077BU7-β1-BI167107
46.15Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
46.15Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
46.15Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
46.15Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
46.15Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
46.15Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
46.15Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
46.15Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
46.15Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
46.15Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
46.15Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
46.15Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
46.15Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
46.15Consensushistamine_onOrthosteric Ligandh1_on h4_on
46.15Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
46.15Consensustar_onOrthosteric Ligandta1_on
45.45Single6HLLCP999946HLL-NK1-CP99994
45.45Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
45.45Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
45.45Single8GGYEpinephrine8GGY-β2-Epinephrine
45.45Single8GH1Epinephrine8GH1-β2-Epinephrine
45.45Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
45.45Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
45.45Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
45.45Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
45.45Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
44.44Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
44.44Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
43.75Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
43.75Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
43.75Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
43.75Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
43.75Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
43.75Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
43.75Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.86Single5C1MBU725C1M-μ-BU72
42.86Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
42.86Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
42.86Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
42.86Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
42.86Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
42.86Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
42.86Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
42.86Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.86Single8EA0Iperoxo8EA0-M3-Iperoxo
42.86Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
42.86Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
42.86Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
42.86Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
42.86Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.86Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
42.86Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.67Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
41.67Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
41.67Single5DHHSB-6121115DHH-NOP-SB-612111
41.67Single6AKXA4R6AKX-CCR5-A4R
41.67Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
41.67Single6KUXRS-799486KUX-α2a-RS-79948
41.67Single6ME2Ramelteon6ME2-MT1-Ramelteon
41.67Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
41.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
41.67Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
41.67Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
41.67Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.67Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
41.67Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Single8IWESpermidine8IWE-TAAR9-Spermidine
41.67Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
41.67Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Consensusalpha1_onOrthosteric Ligandalpha1a_on
41.67Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.67Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
41.18Single4UG2CGS216804UG2-A2A-CGS21680
41.18Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
41.18Single8X5YAstemizole8X5Y-H1-Astemizole
40.00Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
40.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
40.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
40.00Single4U15Tiotropium4U15-M3-Tiotropium
40.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
40.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
40.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
40.00Single6OL9Tiotropium6OL9-M5-Tiotropium
40.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
40.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
40.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
40.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
40.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
40.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
40.00Single8E0GBU728E0G-μ-BU72
40.00Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
40.00Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
40.00Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
40.00Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
40.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
40.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
40.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
40.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
40.00Consensusa2_onOrthosteric Liganda2a_on a2b_on
40.00Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
40.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
40.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
40.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
40.00Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
38.89Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
38.46Single2YDOAdenosine2YDO-A2A-Adenosine
38.46Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
38.46Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
38.46Single4MBSMaraviroc4MBS-CCR5-Maraviroc
38.46Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
38.46Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
38.46Single6IQLL7458706IQL-D4-L745870
38.46Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
38.46Single6TPGEMPA6TPG-OX2-EMPA
38.46Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
38.46Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
38.46Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
38.46Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
38.46Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
38.46Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
38.46Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.46Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
38.46Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
38.46Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
38.46Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
37.50Single5CXVTiotropium5CXV-M1-Tiotropium
37.50Single6CM4Risperidone6CM4-D2-Risperidone
37.50Single6HLPNetupitant6HLP-NK1-Netupitant
37.50Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
37.50Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
37.50Single7YITNalfurafine7YIT-κ-Nalfurafine
37.50Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
37.50Single8JWZAB9288JWZ-A2A-AB928-Na
37.50Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
37.50Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
37.50Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
37.50Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
37.50Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.84Single3QAKUK-4320973QAK-A2A-UK-432097
36.84Single6HLOAprepitant6HLO-NK1-Aprepitant
36.36Single3UZAGTPL92363UZA-A2A-GTPL9236
36.36Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
36.36Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
36.36Single7WC5Psilocin7WC5-5-HT2A-Psilocin
36.36Single8GGZEpinephrine8GGZ-β2-Epinephrine
36.36Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
35.71Single2Y01Dobutamine2Y01-β1-Dobutamine
35.71Single4EJ4Naltrindole4EJ4-δ-Naltrindole
35.71Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
35.71Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
35.71Single5DSGTiotropium5DSG-M4-Tiotropium
35.71Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
35.71Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
35.71Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
35.71Single6DRXLisuride6DRX-5-HT2B-Lisuride
35.71Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.71Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
35.71Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
35.71Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
35.71Single7UL4Alvimopan7UL4-μ-Alvimopan
35.71Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
35.71Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
35.71Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
35.71Single8CU6LJ-45178CU6-A2A-LJ-4517
35.71Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
35.71Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
35.71Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
35.71Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
35.71Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
35.71Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
35.71Consensusadenosine_onOrthosteric Liganda1_on a2_on
35.71Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
35.71Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
35.71Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
35.71Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
35.71Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
35.71Consensusnucleotide_onOrthosteric Ligandadenosine_on
35.29Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
35.29Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
35.29Single7EZCUKA7EZC-A2A-UKA
35.29Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.29Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
35.29Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
35.29Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
35.29Consensusendothelin_offOrthosteric Ligandetb_off
35.29Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
35.29Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
35.00Single5WF5UK-4320975WF5-A2A-UK-432097
33.33Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
33.33Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
33.33Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
33.33Single2Y00Dobutamine2Y00-β1-Dobutamine
33.33Single5MZPCaffeine5MZP-A2A-Caffeine-Na
33.33Single5NM2ZM2413855NM2-A2A-ZM241385-Na
33.33Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
33.33Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
33.33Single5WQCEMPA5WQC-OX2-EMPA
33.33Single5XPRBosentan5XPR-ETB-Bosentan
33.33Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
33.33Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
33.33Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
33.33Single6LUQHaloperidol6LUQ-D2-Haloperidol
33.33Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
33.33Single6PT3DPI-2876PT3-δ-DPI-287
33.33Single6TP4ACT-4622066TP4-OX1-ACT-462206
33.33Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
33.33Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
33.33Single7C61Ergotamine7C61-5-HT1B-Ergotamine
33.33Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
33.33Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
33.33Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
33.33Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
33.33Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
33.33Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
33.33Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
33.33Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
33.33Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
33.33Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
33.33Single8QOTNanobody E8QOT-μ-Nanobody E
33.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
33.33Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
33.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
33.33Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
33.33Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
33.33Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
31.82Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
31.58Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
31.58Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
31.58Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
31.58Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
31.58Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
31.25Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
31.25Single5X93K-87945X93-ETB-K-8794
31.25Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
31.25Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
31.25Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
31.25Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
31.25Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
31.25Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
31.25Single7TUYGSK682753A7TUY-GPR183-GSK682753A
31.25Single7W41PD1762527W41-BB2-PD176252
31.25Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
31.25Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
31.25Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
31.25Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
31.25Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
31.25Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Consensusadenosine_offOrthosteric Liganda1_off a2_off
31.25Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
31.25Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
31.25Consensusbombesin_offOrthosteric Ligandbb2_off
31.25Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
31.25Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
31.25Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
31.25Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
31.25Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
31.25Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
30.77Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
30.77Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
30.77Single5K2DZM2413855K2D-A2A-ZM241385
30.77Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
30.77Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
30.77Single6AKYMaraviroc6AKY-CCR5-Maraviroc
30.77Single6B73PubChem 1319551386B73-κ-PubChem 131955138
30.77Single6JZHZM2413856JZH-A2A-ZM241385-Na
30.77Single6PS7ZM2413856PS7-A2A-ZM241385-Na
30.77Single6TODEMPA6TOD-OX1-EMPA-Na
30.77Single7F8ULintitript7F8U-CCKA-Lintitript
30.77Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
30.77Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
30.77Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
30.77Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
30.77Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
30.77Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
30.77Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
30.77Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.77Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
30.77Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
30.77Single8GNGIstradefylline8GNG-A2A-Istradefylline
30.77Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
30.77Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
30.77Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
30.77Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
30.77Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
30.77Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
30.77Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
30.77Consensusorexin_offOrthosteric Ligandox2_off ox1_off
30.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
30.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
30.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
30.00Single8PWNTheophylline8PWN-A2A-Theophylline
30.00Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
30.00Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
29.41Single6A93Risperidone6A93-5-HT2A-Risperidone
29.41Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
29.41Single6ZG4HTL00099366ZG4-M1-HTL0009936
29.41Single7DFPSpiperone7DFP-D2-Spiperone
29.41Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
29.41Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
29.41Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
29.41Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
29.41Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
29.41Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
29.41Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
29.41Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
28.57Single3REYPubChem 56973REY-A2A-PubChem 5697
28.57Single4ZJCSB-6740424ZJC-OX1-SB-674042
28.57Single5IU4ZM2413855IU4-A2A-ZM241385-Na
28.57Single5IU7Q274563465IU7-A2A-Q27456346-Na
28.57Single5IUBQ274563445IUB-A2A-Q27456344-Na
28.57Single5JTBZM2413855JTB-A2A-ZM241385
28.57Single5K2BZM2413855K2B-A2A-ZM241385-Na
28.57Single5K2CZM2413855K2C-A2A-ZM241385-Na
28.57Single5NLXZM2413855NLX-A2A-ZM241385-Na
28.57Single5NM4ZM2413855NM4-A2A-ZM241385-Na
28.57Single5UVIZM2413855UVI-A2A-ZM241385
28.57Single6AQFZM2413856AQF-A2A-ZM241385
28.57Single6DS0Ly2660976DS0-5-HT2B-Ly266097
28.57Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
28.57Single6PT2KGCHM076PT2-δ-KGCHM07
28.57Single6TPKRetosiban6TPK-OT-Retosiban
28.57Single6V9SGTPL114036V9S-OX1-GTPL11403
28.57Single6VI4JDTic6VI4-κ-JDTic
28.57Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
28.57Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
28.57Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
28.57Single7AROLUF58337ARO-A2A-LUF5833-Na
28.57Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
28.57Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
28.57Single7T32ZM2413857T32-A2A-ZM241385
28.57Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
28.57Single7VODCariprazine7VOD-5-HT2A-Cariprazine
28.57Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
28.57Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
28.57Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
28.57Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
28.57Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
28.57Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
28.57Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
28.57Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
28.57Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
28.57Consensussensory_offOrthosteric Ligandopsin_off
28.57Consensusvasopressin-ot_offOrthosteric Ligandot_off
27.78Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
27.78Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
27.78Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
27.78Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
27.78Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
27.78Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
27.78Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
27.78Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
27.78Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
27.78Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
27.78Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
27.78Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
27.78Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
27.78Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
27.78Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
27.78Consensusorexin_onOrthosteric Ligandox2_on
27.78Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
27.27Single3RFMCaffeine3RFM-A2A-Caffeine
27.27Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
27.27Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
27.27Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
27.27Single8A2OTheophylline8A2O-A2A-Theophylline-Na
27.27Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
27.27Consensussensory_onOrthosteric Ligandopsin_on
27.27Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.92Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
26.92Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
26.67Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
26.67Single3EMLZM2413853EML-A2A-ZM241385
26.67Single4EIYZM2413854EIY-A2A-ZM241385-Na
26.67Single5IU8Q274563475IU8-A2A-Q27456347-Na
26.67Single5K2AZM2413855K2A-A2A-ZM241385-Na
26.67Single5OLGZM2413855OLG-A2A-ZM241385-Na
26.67Single5UENDU1725UEN-A1-DU172
26.67Single5VRAZM2413855VRA-A2A-ZM241385-Na
26.67Single6LPJZM2413856LPJ-A2A-ZM241385-Na
26.67Single6LPKZM2413856LPK-A2A-ZM241385-Na
26.67Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
26.67Single6S0LZM2413856S0L-A2A-ZM241385
26.67Single6TOTLemborexant6TOT-OX1-Lemborexant
26.67Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
26.67Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
26.67Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
26.67Single7PYRPSB-21157PYR-A2A-PSB-2115
26.67Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
26.67Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
26.67Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
26.67Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
26.67Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
26.67Consensusa2_offOrthosteric Liganda2a_off
26.67Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
26.67Consensuscck_offOrthosteric Ligandccka_off
26.67Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
26.67Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
26.67Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
26.67Consensusgi_hcarOrthosteric Ligandgi_hca
26.67Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
26.67Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
26.32Single5WF6UK-4320975WF6-A2A-UK-432097
26.32Single5ZTYAM102575ZTY-CB2-AM10257
26.32Single7SK9CCX6627SK9-ACKR3-CCX662
26.32Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single7XN9L-054,5227XN9-SST2-L-054,522
26.32Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
26.32Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
26.32Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
26.32Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
26.32Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
26.32Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
26.32Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
26.32Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
26.32Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
26.09Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
25.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
25.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
25.00Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
25.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
25.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
25.00Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
25.00Single5N2SPSB365N2S-A1-PSB36
25.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
25.00Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
25.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
25.00Single6LPLZM2413856LPL-A2A-ZM241385-Na
25.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
25.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
25.00Single6S0QZM2413856S0Q-A2A-ZM241385
25.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
25.00Single6TP6Filorexant6TP6-OX1-Filorexant
25.00Single6WQAZM2413856WQA-A2A-ZM241385-Na
25.00Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
25.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
25.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
25.00Single7F8XNN90567F8X-CCKA-NN9056
25.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
25.00Single7RM5ZM2413857RM5-A2A-ZM241385-Na
25.00Single7SINNPS-21437SIN-CaS-NPS-2143
25.00Single7SINNPS-21437SIN-CaS-NPS-2143
25.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
25.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
25.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
25.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
25.00Single8FYNZM2413858FYN-A2A-ZM241385-Na
25.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
25.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
25.00Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
25.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
25.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
25.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
25.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
25.00Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
25.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
25.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
25.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
25.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
25.00Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
25.00Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
25.00Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
25.00Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
25.00Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
25.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
25.00Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
25.00Consensussst_onOrthosteric Ligandsst2_on sst4_on
24.00Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
23.81Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
23.81Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
23.81Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
23.81Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
23.81Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
23.53Single4DJHJDTic4DJH-κ-JDTic
23.53Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
23.53Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
23.53Single7EPENAM5637EPE-mGlu-NAM563
23.53Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
23.53Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
23.53Single7PX4PSB-21137PX4-A2A-PSB-2113
23.53Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
23.53Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
23.53Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
23.53Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
23.53Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
23.53Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
23.53Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
23.53Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
23.53Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
23.53Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
23.53Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
23.53Consensuscck_onOrthosteric Ligandccka_on cckb_on
23.53Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
23.53Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
23.53Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
23.53Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
23.53Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
23.08Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
23.08Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
23.08Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
23.08Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
23.08Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
23.08Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
23.08Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
23.08Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
23.08Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
23.08Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
23.08Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
23.08Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
23.08Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
23.08Single8K5BNiacin8K5B-HCA2-Niacin
23.08Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
23.08Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
23.08Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
23.08Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
23.08Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
22.73Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
22.73Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
22.73Consensusangiotensin_onOrthosteric Ligandat1_on
22.73Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
22.73Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
22.22Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
22.22Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
22.22Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
22.22Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
22.22Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
22.22Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
22.22Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
22.22Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
22.22Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
22.22Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
22.22Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
22.22Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
22.22Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
22.22Single8WU1KCA8WU1-CB1-KCA-Arrestin1
22.22Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
22.22Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
22.22Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
22.22Consensusdp_offOrthosteric Liganddp2_off
22.22Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
22.22Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
22.22Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
22.22Consensusgs_steroidOrthosteric Ligandgs_bileacid
22.22Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
22.22Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
21.74Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
21.74Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
21.74Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
21.74Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
21.74Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
21.43Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
21.43Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
21.43Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
21.43Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
21.43Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
21.43Single3PWHZM2413853PWH-A2A-ZM241385
21.43Single4S0VSuvorexant4S0V-OX2-Suvorexant
21.43Single5WS3EMPA5WS3-OX2-EMPA
21.43Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
21.43Single6TPJSuvorexant6TPJ-OX2-Suvorexant
21.43Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
21.43Single7BR3Elagolix7BR3-GnRH1-Elagolix
21.43Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
21.43Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
21.43Single7XRRLemborexant7XRR-OX2-Lemborexant
21.43Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
21.43Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
21.43Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
21.43Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
21.43Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
21.43Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
21.43Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
21.43Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
21.43Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
21.43Consensusgt_class-aOrthosteric Ligandgt_opsin
21.43Consensusgt_opsinOrthosteric Ligandgt_sensory
21.43Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
21.43Consensusmglu_onOther Ligandmglu2_on mglu4_on
21.05Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
21.05Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
21.05Single6K1QIRL25006K1Q-ETB-IRL2500
21.05Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
21.05Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
21.05Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
21.05Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
21.05Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
21.05Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
21.05Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
21.05Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
21.05Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Consensussteroid_onOrthosteric Ligandbileacid_on
20.83Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
20.83Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
20.83Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.83Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
20.83Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
20.83Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
20.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
20.00Single5EE7MK08935EE7-Glucagon-MK0893
20.00Single6MH8ZM2413856MH8-A2A-ZM241385
20.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
20.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
20.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
20.00Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
20.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
20.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
20.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
20.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
20.00Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
20.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
20.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
20.00Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
20.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
20.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
20.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
20.00Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
20.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
20.00Single8K5CAcipimox8K5C-HCA2-Acipimox
20.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
20.00Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
20.00Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
20.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
20.00Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
20.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
20.00Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
20.00Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
20.00Consensusgnrh_offOrthosteric Ligandgnrh1_off
20.00Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
20.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
20.00Consensushca_onOrthosteric Ligandhca2_on hca3_on
20.00Consensushcar_onOrthosteric Ligandhca_on
20.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
20.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
20.00Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
20.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
20.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
20.00Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
20.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
20.00Consensuss1p_offOrthosteric Ligands1p1_off
19.23Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
19.23Consensusendothelin_onOrthosteric Ligandetb_on eta_on
19.23Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
19.05Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
19.05Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
19.05Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
19.05Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
19.05Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
19.05Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
19.05Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
19.05Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
18.75Single4YAYZD-71554YAY-AT1-ZD-7155
18.75Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
18.75Single6D27CAY104716D27-DP2-CAY10471
18.75Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
18.75Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
18.75Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
18.75Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
18.75Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
18.75Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
18.75Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
18.75Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
18.75Single8K5DGSK2560738K5D-HCA2-GSK256073
18.75Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
18.75Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
18.75Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
18.75Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
18.52Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
18.52Single6IGLIRL16206IGL-ETB-IRL1620
18.52Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
18.52Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
18.52Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
18.18Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
18.18Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
18.18Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
18.18Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
18.18Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
18.18Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
18.18Consensusclass-c_onOther Ligandgabab_on mglu_on
17.86Single5GLHEndothelin-15GLH-ETB-Endothelin-1
17.86Single6IGKEndothelin-36IGK-ETB-Endothelin-3
17.65Single4NTJAZD12834NTJ-P2Y12-AZD1283
17.65Single5CGCHTL142425CGC-mGlu5-HTL14242
17.65Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
17.65Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
17.65Single7C4SS1P7C4S-S1P3-S1P
17.65Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
17.65Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
17.65Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
17.65Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
17.65Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
17.39Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
17.39Single6W25SHU91196W25-MC4-SHU9119-Ca
17.39Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
17.39Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
17.39Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
17.39Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
17.39Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
17.24Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
17.24Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
16.67Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
16.67Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
16.67Single5XR8AM8415XR8-CB1-AM841
16.67Single5XRAAM115425XRA-CB1-AM11542
16.67Single6JODAngiotensin II6JOD-AT2-Angiotensin II
16.67Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
16.67Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
16.67Single6TQ9SB-4081246TQ9-OX1-SB-408124
16.67Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
16.67Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
16.67Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
16.67Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
16.67Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
16.67Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
16.67Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
16.67Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
16.67Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
16.67Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
16.67Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
16.67Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
16.67Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
16.67Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
16.67Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
16.67Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
16.67Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
16.67Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
16.67Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
16.67Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
16.67Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
16.67Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Consensuslpa_offOrthosteric Ligandlpa1_off
16.67Consensuslpa_onOrthosteric Ligandlpa1_on
16.13Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
16.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
16.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
16.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
16.00Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
16.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
16.00Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
16.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
16.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
16.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
15.79Single4N4WSANT-14N4W-SMO-SANT-1
15.79Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
15.79Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
15.79Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
15.79Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
15.79Single7K15MKD0467K15-BLT1-MKD046-Na
15.79Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
15.79Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
15.79Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
15.79Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
15.79Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
15.79Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
15.79Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
15.79Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
15.79Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
15.79Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
15.79Consensusblt_offOrthosteric Ligandblt1_off
15.79Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
15.79Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
15.79Consensusclass-b2_onOrthosteric Ligandadgrg_on
15.79Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
15.79Consensusgi_class-fOther Ligandgi_frizzled
15.79Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
15.79Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
15.79Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
15.38Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
15.38Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
15.38Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
15.38Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
15.38Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
15.38Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
15.38Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
15.38Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
15.38Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
15.38Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.38Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
15.38Consensusclass-d_onOrthosteric Ligandste2_on
15.38Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
15.38Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single5CGDHTL142425CGD-mGlu5-HTL14242
15.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
15.00Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
15.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
15.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
15.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
15.00Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
15.00Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
15.00Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
14.81Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
14.81Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
14.81Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.81Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
14.81Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
14.81Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
14.81Consensusgi_class-dOrthosteric Ligandgi_ste
14.81Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.81Consensusgo_class-b1Orthosteric Ligandgo_crf
14.81Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
14.81Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
14.29Single3OE9IT1t3OE9-CXCR4-IT1t
14.29Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
14.29Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
14.29Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
14.29Single6LMLGlucagon6LML-Glucagon-Glucagon
14.29Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
14.29Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
14.29Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
14.29Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
14.29Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
14.29Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
14.29Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
14.29Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
14.29Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
14.29Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
14.29Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
14.29Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
14.29Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
14.29Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
14.29Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
14.29Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
14.29Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
14.29Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8IY6Endothelin-18IY6-ETB-Endothelin-1
14.29Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
14.29Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
14.29Consensusclass-d_offOrthosteric Ligandste2_off
14.29Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
14.29Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
14.29Consensusgo_class-b2Orthosteric Ligandgo_adhesion
14.29Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
14.29Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
14.29Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
14.29Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
13.79Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
13.79Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
13.79Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
13.64Single4XT1Fractalkine4XT1-US28-Fractalkine
13.64Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.64Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
13.64Single7QA8Peptide7QA8-STE2-Peptide
13.64Single7QA8Peptide7QA8-STE2-Peptide
13.64Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
13.64Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
13.64Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
13.64Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
13.64Consensusclass-d_offOrthosteric Ligandste2_off
13.64Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
13.51Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
13.33Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
13.33Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
13.33Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
13.33Single7F8YDevazepide7F8Y-CCKA-Devazepide
13.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
13.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.33Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
13.33Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
13.33Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
13.33Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
13.33Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
13.33Single8IHKAcifran8IHK-HCA3-Acifran
13.33Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
13.33Consensusglp_onOrthosteric Ligandglp1_on glp2_on
13.33Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
13.33Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
13.04Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
13.04Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
13.04Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
13.04Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
13.04Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
13.04Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
13.04Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
13.04Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
13.04Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
13.04Consensussst_offOrthosteric Ligandsst2_off
13.04Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
12.90Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
12.50Single3OE0CVX153OE0-CXCR4-CVX15
12.50Single6FFIMMPEP6FFI-mGlu5-MMPEP
12.50Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
12.50Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
12.50Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
12.50Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
12.50Single6ZG9GSK10347026ZG9-M1-GSK1034702
12.50Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
12.50Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
12.50Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
12.50Single7XNACYN1548067XNA-SST2-CYN154806
12.50Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
12.50Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
12.50Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
12.50Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
12.50Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
12.50Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
12.50Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
12.50Consensusclass-c_offOther Ligandgabab_off mglu_off
12.50Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
12.50Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
12.50Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
12.50Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
12.50Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
12.12Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
12.12Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
12.12Consensuspth_onOrthosteric Ligandpth1_on pth2_on
12.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
12.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
12.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
12.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
12.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
12.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
12.00Consensusclass-d_onOrthosteric Ligandste2_on
12.00Consensusgi_class-dOrthosteric Ligandgi_ste
12.00Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
12.00Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
12.00Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
12.00Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
11.76Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
11.76Single5TGZAM65385TGZ-CB1-AM6538
11.76Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
11.76Single6FFHFenobam6FFH-mGlu5-Fenobam
11.76Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
11.76Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
11.76Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
11.76Single6GPSMK08126GPS-CCR2-MK0812
11.76Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
11.76Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
11.76Single7F83PF-051904577F83-Ghrelin-PF-05190457
11.76Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
11.76Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
11.76Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
11.76Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.76Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
11.76Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
11.76Consensusblt_onOrthosteric Ligandblt1_on
11.76Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
11.76Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
11.76Consensusleuko_onOrthosteric Ligandblt_on
11.76Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
11.54Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
11.54Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
11.54Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
11.54Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
11.54Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.43Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
11.43Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
11.11Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
11.11Single4XT3Fractalkine4XT3-US28-Fractalkine
11.11Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
11.11Single6FJ3PTH6FJ3-PTH1-PTH
11.11Single6GPXMK08126GPX-CCR2-MK0812
11.11Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
11.11Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
11.11Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
11.11Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
11.11Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
11.11Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
11.11Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
11.11Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
11.11Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
11.11Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
11.11Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
11.11Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
11.11Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
11.11Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
11.11Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
11.11Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
11.11Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
11.11Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
11.11Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
11.11Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
11.11Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
11.11Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
11.11Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
11.11Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
11.11Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
10.71Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
10.71Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
10.71Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
10.71Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
10.71Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
10.71Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
10.71Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
10.71Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.53Single5TZR-5TZR-FFA1 (GPR40)-MK8666
10.53Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
10.53Single7F1TMIP-1a7F1T-CCR5-MIP-1a
10.53Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
10.53Single7P2L4YI7P2L-mGlu5-4YI
10.53Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
10.53Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
10.53Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
10.53Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
10.53Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
10.53Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
10.53Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
10.53Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
10.53Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
10.53Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
10.53Consensuschemerin_onOrthosteric Ligandcml1_on
10.53Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
10.34Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.34Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
10.34Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
10.34Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
10.34Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
10.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
10.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
10.00Single4XESNeurotensin4XES-NTS1-Neurotensin
10.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
10.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
10.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
10.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
10.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
10.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
10.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
10.00Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
10.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
10.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
10.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
10.00Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
10.00Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
10.00Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
10.00Consensusnts_offOrthosteric Ligandnts1_off
10.00Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
9.52Single4BUONeurotensin4BUO-NTS1-Neurotensin
9.52Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
9.52Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
9.52Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
9.52Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
9.52Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
9.52Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
9.52Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
9.52Consensuscyslt_offOrthosteric Ligandcyslt2_off
9.52Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
9.52Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.38Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
9.38Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
9.38Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
9.09Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
9.09Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
9.09Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
9.09Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
9.09Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
9.09Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
9.09Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Consensusgs_class-b2Orthosteric Ligandgs_adgr
9.09Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
9.09Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
9.09Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
8.82Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
8.70Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
8.70Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
8.70Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
8.70Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.70Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
8.70Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
8.70Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
8.70Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
8.33Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
8.33Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
8.33Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
8.33Single7SHEPI; PE7SHE-GPR158-PI; PE
8.33Single7SK5CXCL127SK5-ACKR3-CXCL12
8.33Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
8.33Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
8.33Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
8.33Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
8.33Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
8.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
8.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
8.00Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
8.00Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
8.00Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.89Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
7.69Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
7.69Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
7.69Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
7.69Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
7.69Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
7.69Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
7.69Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
7.69Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
7.41Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
7.41Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
7.41Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
7.41Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
7.14Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
7.14Single3OE6IT1t3OE6-CXCR4-IT1t
7.14Single3OE8IT1t3OE8-CXCR4-IT1t
7.14Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
7.14Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
7.14Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
7.14Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
7.14Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
7.14Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
7.14Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
6.90Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
6.90Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
6.90Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
6.67Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
6.67Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
6.67Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
6.67Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
6.67Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
6.67Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Consensusclass-t_onOrthosteric Ligandtaste2_on
6.67Consensusgs_class-tOrthosteric Ligandgs_taste
6.67Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
6.67Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
6.67Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
6.45Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Single3ODUIT1t3ODU-CXCR4-IT1t
6.25Single5U09Taranabant5U09-CB1-Taranabant
6.25Single5ZKQABT-4915ZKQ-PAF-ABT-491
6.25Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
6.25Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
6.25Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
6.25Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
6.25Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
6.25Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
6.25Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
6.25Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
6.25Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
6.25Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.06Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
5.88Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
5.88Single6ZINSR486926ZIN-NTS1-SR48692
5.88Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
5.88Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88Single7VV6C48/807VV6-MRGPRX2-C48/80
5.88Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
5.88Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
5.88Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
5.88Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
5.88Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88Single8IYXYL-3658IYX-GPR34-YL-365
5.88Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.88Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
5.56Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
5.56Single6IIVDaltroban6IIV-TP-Daltroban
5.56Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.56Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
5.56Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.56Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
5.56Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
5.56Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.56Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
5.56Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
5.56Consensushcar_offOrthosteric Ligandsuccinate_off
5.56Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
5.56Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
5.56Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
5.26Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
5.26Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
5.26Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
5.26Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.26Single6Z4SSR486926Z4S-NTS1-SR48692
5.26Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
5.26Single7YXAONO-54306087YXA-S1P5-ONO-5430608
5.26Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
5.26Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
5.26Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
5.26Consensusep_offOrthosteric Ligandep4_off
5.26Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
5.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
5.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
5.00Single5V56TC1145V56-SMO-TC114
5.00Single6OS1TRV0266OS1-AT1-TRV026
5.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
5.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
5.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
5.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
5.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
5.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
5.00Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.00Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
5.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
5.00Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
4.76Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
4.76Single4PY02MeSATP4PY0-P2Y12-2MeSATP
4.76Single5X33BIIL2605X33-BLT1-BIIL260
4.76Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
4.76Single6IIURamatroban6IIU-TP-Ramatroban
4.76Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
4.76Single6OS2TRV0266OS2-AT1-TRV026
4.76Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
4.76Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.76Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
4.76Single7SHEPI; PE7SHE-GPR158-PI; PE
4.76Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
4.76Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.76Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
4.76Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.76Consensusnts_onOrthosteric Ligandnts1_on
4.55Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
4.55Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
4.55Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.55Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
4.55Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
4.55Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.55Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
4.55Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
4.55Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.55Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Single6KNMJN241-96KNM-Apelin-JN241-9
4.35Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
4.35Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
4.17Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
4.17Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
4.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
4.00Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.00Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
3.85Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.70Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
3.57Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
3.45Single7SK3CXCL127SK3-ACKR3-CXCL12
3.45Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
3.45Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
3.33Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
3.33Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
3.23Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
3.23Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
3.23Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
3.23Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
3.12Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
3.12Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.03Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
2.94Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
2.56Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2

Consensus Members
Id Members
7XT8 7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
Net Summary
Imin 3.72
Number of Linked Nodes 263
Number of Links 285
Number of Hubs 46
Number of Links mediated by Hubs 164
Number of Communities 7
Number of Nodes involved in Communities 48
Number of Links involved in Communities 61
Path Summary
Number Of Nodes in MetaPath 53
Number Of Links MetaPath 52
Number of Shortest Paths 89630
Length Of Smallest Path 3
Average Path Length 14.5895
Length of Longest Path 29
Minimum Path Strength 1.485
Average Path Strength 6.99187
Maximum Path Strength 15.34
Minimum Path Correlation 0.7
Average Path Correlation 0.940693
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4
Average % Of Corr. Nodes 55.4041
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 60.2157
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
5ht_on5ht1_on
5ht2_on
5ht4_on
5ht5_on
5ht6_on
5ht7_on



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Download 5ht4_on.zip



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