Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.43 2.48419
2G.HN.52 3.93254114
3G.S1.02 5.76445
4G.S1.04 2.51547
5G.S1.06 3.5075449
6G.S1.07 2.775409
7G.s1h1.06 2.65449
8G.H1.01 4.32649
9G.H1.04 3.62143747
10G.H1.08 2.765449
11G.S2.01 3.82618
12G.S2.08 8.4275445
13G.S3.01 4.025444
14G.S3.03 7.085647
15G.S3.04 6.2675407
16G.S3.05 3.016547
17G.S3.06 3.008516
18G.S3.07 3.8775449
19G.S3.08 5.3825419
20G.s3h2.03 5.738519
21G.H2.02 3.355418
22G.H2.03 4.58419
23G.H2.06 4.67667619
24G.H2.07 6.256519
25G.H2.10 2.578517
26G.h2s4.01 2.934519
27G.S4.04 3.916539
28G.S4.05 2.13333647
29G.S4.06 4.2075437
30G.s4h3.01 4.6575436
31G.s4h3.04 4.766538
32G.s4h3.11 5.6325489
33G.s4h3.15 4.03409
34G.H3.01 4.0075409
35G.H3.02 2.25438
36G.H3.06 2.82333636
37G.H3.09 4.3025439
38G.H3.13 2.84536
39G.H3.17 4.868505
40G.H3.18 5.42699
41G.S5.03 2.286548
42G.S5.04 4.208539
43G.S5.05 2.51649
44G.S5.06 4.02667639
45G.S5.07 3.3825449
46G.HG.04 3.896538
47G.HG.07 4.4225439
48G.HG.13 4.908536
49G.hgh4.01 4.77435
50G.hgh4.02 4.65857738
51G.hgh4.05 5.8975436
52G.H4.03 4.998534
53G.H4.05 5.9825435
54G.H4.10 5.695436
55G.H4.11 2.152537
56G.H4.12 4.07435
57G.h4s6.02 4.3025437
58G.h4s6.11 3.245437
59G.S6.02 4.814508
60G.S6.03 5.776535
61G.S6.04 6.465449
62G.S6.05 3.14535
63G.s6h5.01 3.265449
64G.s6h5.02 2.765447
65G.H5.03 4.4375448
66G.H5.07 1.68649
67G.H5.08 5.864548
68G.H5.11 3.768548
69G.H5.23 3.075454
70G.H5.25 2.6675407
71b.1x11 2.096138
72b.1x19 5.095406
73b.h2x5 3.862515
74b.lhb1x11 2.578514
75b.b1x4 4.3025407
76b.b1x6 6.1175419
77b.l1x3 6.528519
78b.l1x6 6.8125419
79b.l1x7 3.8075419
80b.b2x1 7.34518
81b.b2x3 4.318506
82b.b2x5 3.88833607
83b.b3x3 2.4875418
84b.b3x4 3.392519
85b.b3x6 4.67419
86b.l3x1 4.01833619
87b.l3x2 2.795419
88b.b4x2 2.87408
89b.b4x3 2.72833617
90b.b4x4 3.602518
91b.b4x5 2.16833617
92b.b4x6 7.658519
93b.b4x7 6.2575418
94b.l4x1 3.135405
95b.l4x2 7.732514
96b.b5x2 3.564507
97b.b5x3 4.665619
98b.b5x5 4.2125405
99b.b5x7 3.1875817
100b.l5x1 2.16518
101b.l5x5 4.30143719
102b.b6x3 2.6025418
103b.b6x5 2.746516
104b.l6x1 2.5775466
105b.l6x5 5.328564
106b.b7x1 5.03833664
107b.b7x2 2.222518
108b.b7x3 2.238569
109b.b7x4 2.246518
110b.l7x1 1.8025419
111b.l7x2 3.77833619
112b.b8x3 2.10333666
113b.b8x4 3.00429716
114b.l8x1 2.56415
115b.l8x3 2.5654103
116b.l8x7 5.99254103
117b.l8x8 3.9475414
118b.b9x3 3.2475416
119b.b9x4 4.576569
120b.l9x3 2.198569
121b.l9x6 2.61833618
122b.b10x1 1.945419
123b.b10x2 2.3975416
124b.b10x3 1.7575468
125b.b10x4 4.0975416
126b.b10x5 3.60625869
127b.l10x1 5.962513
128b.l10x4 4.458563
129b.b11x2 4.9475417
130b.b11x3 3.224565
131b.b11x4 2.84519
132b.b11x6 2.61519
133b.l11x2 3.832519
134b.b12x3 2.765418
135b.b12x6 6.59143768
136b.l12x3 4.494205
137b.b13x3 6.7725464
138b.b13x7 6.092517
139b.l13x3 5.79667619
140b.l13x6 3.345619
141b.l13x7 3.42667619
142b.b14x1 3.49418
143b.b14x3 3.406515
144b.b15x1 5.32833619
145b.b15x2 5.68416
146b.b15x3 3.406519
147b.l15x1 5.4225417
148b.l15x2 5.0425419
149b.b16x5 4.2175415
150b.b16x6 6.46833618
151b.b16x7 4.63419
152b.l16x2 6.46419
153b.l16x3 6.2275413
154b.b17x5 4.306517
155b.b17x7 5.17418
156b.l17x3 5.97167619
157b.l17x7 2.9625417
158b.b18x3 4.104518
159b.l18x1 5.49375816
160b.b19x2 5.842516
161b.b19x4 4.578518
162b.b19x5 2.7175415
163b.b19x6 4.8625419
164b.l19x2 4.88419
165b.b20x2 2.63416
166b.b20x4 4.49429718
167b.b20x6 5.618516
168b.b20x7 5.66409
169b.l20x1 2.9225416
170b.b21x1 8.108517
171b.b21x2 3.425406
172b.b21x7 6.30333615
173b.l21x2 4.5825414
174b.l21x5 3.7425414
175b.l21x9 4.61416
176b.b22x1 3.175418
177b.b22x3 1.66333616
178b.b22x5 5.21333617
179b.l22x1 2.3575419
180b.l22x3 3.69419
181b.l22x4 2.8375419
182b.l22x5 4.25667619
183b.b23x1 2.32333615
184b.b23x2 3.4625406
185b.b23x3 3.965417
186b.b23x6 5.02143717
187b.l23x1 7.5825416
188b.l23x2 5.31418
189b.b24x2 4.925415
190b.b24x4 3.78516
191b.b24x5 2.432515
192b.l24x2 3.975616
193b.l24x3 3.685415
194b.b25x3 4.1675415
195b.b25x7 4.255417
196b.l25x3 7.6675419
197b.l25x6 7.726518
198b.l25x7 1.66417
199b.b26x2 3.3675417
200b.b26x3 2.55429716
201b.l26x1 3.675617
202b.l26x3 5.82417
203b.l26x4 1.79519
204b.l26x5 4.038515
205b.b27x1 2.748516
206b.b27x3 3.57333618
207b.b27x5 4.558519
208b.l27x1 10.25519
209b.l27x2 6.7125419
210b.b28x3 3.17857717
211b.b28x4 3.16167616
212b.b28x5 3.175405
213b.b28x6 6.616519
214b.b28x7 4.935419
215g.h1x1 1.80754172
216g.h1x11 3.0975409
217g.h1x14 4.9419
218g.l1x4 5.218518
219g.ctx3 4.18286719
220g.ctx4 3.835417
221g.ctx5 2.795409
222g.ctx6 2.174516
223g.ctx9 2.4075416
224g.ctx14 4.942519
225g.ctx16 5.035618
226NT.L35 4.7285213
2271x31 2.264214
2281x39 3.62667627
2291x43 4.2325427
2301x50 5.566509
2311x53 3.242559
2321x56 3.07557
2331x57 3.34714757
2342x42 4.51407
2352x45 3.27429
2362x46 4.4679
2372x50 5.266579
2382x53 2.805407
2392x56 3.75527
2402x57 3.62571727
2412x59 3.655426
2422x60 4.93626
243E1x49 7.1575425
244E1x50 7.06333628
245E1x52 5.658527
2463x28 4.2425
2473x32 5.5875426
2483x34 1.95525
2493x35 3.1475408
2503x37 3.265626
2513x38 4.378527
2523x40 4.2125477
2533x43 3.604578
2543x46 2.8725408
2553x49 6.9975458
2563x50 2.61559
2573x51 6.105457
2583x53 2.556558
2593x54 2.1475408
2603x55 5.3675456
261I2.P145 2.668558
2624x46 2.7275427
2634x50 5.785429
2644x53 2.1175428
2654x57 3.788527
2664x65 2.1575405
267E2.E182 7.9675421
268E2.F184 3.974521
269E2.K195 8.035423
270E2x50 3.3025429
271E2.F202 3.9625425
2725x40 4.9075425
2735x44 1.8175426
2745x461 5.185426
2755x47 4.8675408
2765x50 3.105479
2775x58 4.74857759
2785x61 1.6075458
2795x64 3.358555
2805x65 3.4725408
2815x70 6.0754234
2826x32 2.9754127
2836x40 2.615457
2846x44 2.5225479
2856x47 2.98254248
2866x48 4.4578
2876x54 4.4475405
2886x59 4.89333624
2897x30 5.1975423
2907x34 5.425425
2917x35 3.265424
2927x38 5.942526
2937x42 4.018527
2947x46 2.4675408
2957x49 2.694579
2967x52 3.855408
2978x47 3.845408
2988x48 4.0665125
2998x50 4.396558
300Lig 16.93362520
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b3x6 b.l1x5 13.89571.71YesNo197
2b.l1x5 b.l3x1 17.62891.52NoYes179
3b.l3x1 b.l5x5 34.14455.48YesYes199
4G.S2.01 b.l5x5 20.42694.7YesYes189
5G.S2.01 G.S3.08 31.9873.07YesYes189
6G.S1.07 G.S3.08 62.31121.49YesYes099
7G.S1.07 G.S4.04 1001.22YesYes099
8G.S4.04 G.S5.04 1003.65YesYes399
9G.S5.04 G.S5.06 1004.15YesYes399
10G.S5.06 G.S6.05 1006.09YesYes395
11G.H4.03 G.S6.05 1002.06YesYes345
12G.H4.03 G.HG.05 10011.22YesNo344
13G.HG.02 G.HG.05 1001.3NoNo394
14G.HG.02 G.HG.03 1006.79NoNo396
15G.HG.03 G.s4h3.02 1003NoNo069
16G.s4h3.02 G.s5hg.01 1007.65NoNo099
17G.s1h1.06 G.s5hg.01 1001.74YesNo099
18G.S5.07 G.s1h1.06 73.13411.7YesYes499
19G.S4.05 G.S5.07 18.72173.15YesYes479
20G.h2s4.01 b.l5x5 20.45214.01YesYes199
21G.S1.05 G.h2s4.01 20.51596.09NoYes099
22G.S1.05 G.S1.07 20.5495.54NoYes099
23G.H1.03 G.s1h1.06 35.7355.46NoYes499
24G.H1.03 G.H1.04 35.75193.04NoYes497
25G.H1.04 G.H1.08 34.92712.92YesYes479
26G.H1.04 G.S5.07 35.7362.83YesYes479
27G.H1.08 G.H5.07 34.54151.52YesYes499
28G.H1.04 G.S5.05 36.53526.28YesYes479
29G.H5.07 G.S5.05 69.05641.31YesYes499
30G.S4.05 G.S5.05 18.31931.4YesYes479
31G.S5.07 G.s6h5.01 18.69345.85YesYes499
32G.S5.05 G.s6h5.01 18.2711.3YesYes499
33G.H5.07 G.H5.11 1001.6YesYes498
34G.H3.12 G.H3.18 19.65912.51NoYes989
35G.H2.08 G.H3.18 19.49732.51NoYes089
36G.H2.08 G.H3.17 19.46392.35NoYes085
37G.H3.17 b.l25x6 19.29212YesYes058
38G.s3h2.03 b.l7x2 10.8973.99YesYes199
39b.b2x1 b.l27x1 17.755313.5YesYes189
40G.H2.10 b.b2x1 12.00612.69YesYes178
41G.H2.02 G.H2.07 19.1943.71YesYes189
42b.b10x1 b.l9x6 14.19661.27YesYes198
43b.l23x1 b.l25x6 13.676717.87YesYes168
44G.H5.11 G.H5.15 1003.07YesNo088
45G.H5.15 I2.P145 1001.69NoYes088
465x64 I2.P145 99.80641.44YesYes558
473x54 G.H5.19 22.56291.42YesNo087
483x54 5x64 97.88731.25YesYes085
493x54 G.H5.23 73.551.64YesYes084
503x53 G.H5.19 22.39534.12YesNo587
513x53 G.H5.23 22.4034.76YesYes584
523x50 G.H5.23 51.00532.79YesYes594
53b.b27x5 b.l27x1 23.61291.24YesYes199
54b.b27x1 g.ctx5 11.49041.49YesYes069
553x46 3x50 50.45281.25YesYes089
562x46 2x50 16.66618.14YesYes799
572x50 7x46 22.54734.34YesYes098
587x42 7x46 17.09231.51YesYes078
593x43 3x46 22.57941.43YesYes088
603x49 3x53 43.95391.33YesYes588
612x42 3x46 19.14815.71YesYes078
622x42 3x49 38.00313.98YesYes078
632x42 3x45 47.38816.92YesNo077
643x45 4x49 47.13321.43NoNo077
655x461 Lig 41.00994.51YesYes260
663x37 5x461 22.56294.25YesYes266
673x37 3x41 23.82793.89YesNo067
683x41 4x49 46.88361.26NoNo077
695x46 5x461 22.54722.66NoYes056
703x41 5x46 22.80232.44NoNo075
71G.S2.01 b.l7x2 10.91587.14YesYes189
72G.S3.08 G.s3h2.03 11.05477.16YesYes199
73G.H3.12 G.S1.07 19.75612.85NoYes089
74G.H2.02 b.l9x6 18.68323.82YesYes188
75b.b27x1 b.b27x3 13.00341.59YesYes168
76b.b10x1 b.b11x6 10.78613.26YesYes199
77G.H2.07 G.S3.08 19.2399.81YesYes199
78b.b27x5 b.l25x3 14.239512.55YesYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x562x601.692YesYes7621
2x563x329.162YesYes7621
2x567x382.952YesYes7622
2x582x592.890NoYes8621
2x59E1x522.142YesYes6712
2x593x287.252YesYes6511
2x59Lig2.342YesYes6010
2x602x641.572YesNo6412
2x603x322.832YesYes6611
2x607x341.32YesYes6511
2x607x3813.692YesYes6612
2x60Lig8.52YesYes6010
2x63E1x508.682NoYes6811
2x63E2x504.032NoYes6912
2x63Lig17.512NoYes6010
2x647x346.492NoYes4521
2x67Lig13.470NoYes4010
E1x49E2.F1842.262YesYes5121
E1x49E2.K19517.032YesYes5322
E1x50E1x5217.042YesYes8712
3x21E1x501.412NoYes8821
3x25E1x509.142NoYes9821
E1x50E2x503.922YesYes8912
E1x50Lig2.192YesYes8010
3x21E1x521.512NoYes8722
3x25E2x503.642NoYes9922
3x283x291.632YesNo5612
3x283x323.962YesYes5611
3x28Lig3.962YesYes5010
3x32Lig6.42YesYes6010
3x375x4614.252YesYes6621
E2.E182E2.T1801.412YesNo1312
E2.T180E2x512.590NoNo3321
E2.E182E2.P1837.862YesNo1111
E2.E182E2.N18613.152YesNo1111
E2.E182Lig9.452YesYes1010
E2.P183E2.V1973.532NoNo1412
E2.P183Lig5.022NoYes1010
E2.F184E2.Q1853.512YesNo1212
E2.F184E2.K1953.722YesYes1312
E2.F184E2.V1977.872YesNo1412
E2.F184Lig2.512YesYes1010
E2.L189E2.N1861.370NoNo5121
E2.N186Lig4.22NoYes1010
E2.T188E2.V1876.350NoNo3221
E2.V187Lig3.532NoYes2010
E2.V197E2x511.310NoNo4321
E2x51Lig11.672NoYes3010
5x36E2.F2027.482NoYes4512
5x366x595.962NoYes4411
5x36Lig10.332NoYes4010
5x395x434.690NoNo6521
5x405x411.572YesNo5512
5x405x441.472YesYes5612
5x406x5910.122YesYes5411
5x40Lig6.472YesYes5010
5x416x602.430NoNo5422
5x435x4619.322NoYes5611
5x43Lig3.522NoYes5010
5x446x591.362YesYes6421
5x465x4612.660NoYes5621
5x461Lig4.512YesYes6010
6x516x555.490NoNo7521
6x547x302.260YesYes5321
6x547x347.50YesYes5521
6x556x591.352NoYes5411
6x55Lig16.752NoYes5010
6x58Lig20.30NoYes4010
6x596x602.232YesNo4412
6x59Lig8.342YesYes4010
7x30E3.I2932.652YesNo3312
7x307x315.12YesNo3411
7x30Lig10.782YesYes3010
7x31Lig9.542NoYes4010
7x34Lig6.412YesYes5010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
100.00Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
62.07Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
60.87Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
60.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
57.69Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
57.69Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
57.14Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
57.14Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
57.14Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
53.57Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
46.15Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
46.15Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
46.15Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
46.15Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
45.45Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
44.44Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
43.33Single8IY6Endothelin-18IY6-ETB-Endothelin-1
42.86Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
42.86Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
42.31Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
41.67Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
41.38Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
40.74Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
40.74Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
40.74Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
40.74Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
40.62Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
40.62Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
40.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
40.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
40.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
40.00Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
40.00Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
40.00Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
40.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
40.00Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
40.00Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
40.00Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
39.29Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
38.71Consensusendothelin_onOrthosteric Ligandetb_on eta_on
38.71Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
38.46Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
38.46Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
38.46Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
38.46Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
38.46Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
38.46Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
37.93Single8ZRTET-18ZRT-ETB-ET-1
37.93Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
37.93Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.50Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
37.50Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
37.50Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
37.04Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
37.04Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
37.04Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
37.04Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
37.04Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
37.04Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
36.67Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
36.36Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
36.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
36.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
35.48Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
35.48Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
35.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
34.78Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
34.78Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.62Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
34.62Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
34.62Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
34.62Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
34.62Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
34.62Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
34.62Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
34.62Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
34.48Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
34.48Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
34.48Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
34.38Single6IGLIRL16206IGL-ETB-IRL1620
34.38Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
34.38Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
34.38Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
34.38Consensusbradykinin_onOrthosteric Ligandbk2_on
34.38Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
34.38Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
33.33Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
33.33Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
33.33Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
33.33Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
33.33Single7F8XNN90567F8X-CCKA-NN9056
33.33Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
33.33Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
33.33Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
33.33Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
33.33Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
33.33Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
33.33Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
33.33Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
33.33Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
33.33Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
33.33Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
33.33Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
33.33Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
33.33Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.35Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
32.26Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
32.26Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
32.26Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
32.26Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
32.26Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
32.26Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
32.14Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
32.14Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
32.14Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
32.14Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
32.14Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
32.14Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
32.14Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
32.14Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
32.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
32.00Single6OS2TRV0266OS2-AT1-TRV026
32.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
32.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
32.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
32.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
32.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
32.00Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
32.00Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.00Single8XWSCXCL58XWS-CXCR2-CXCL5
32.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
32.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
32.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
32.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
32.00Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
32.00Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
31.82Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
31.43Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
31.43Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
31.25Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
31.25Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
31.25Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
31.03Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
31.03Single6PT2KGCHM076PT2-δ-KGCHM07
31.03Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.03Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
31.03Consensusangiotensin_onOrthosteric Ligandat1_on
31.03Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
31.03Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
31.03Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
31.03Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
31.03Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
30.77Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
30.77Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
30.77Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
30.77Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
30.77Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
30.77Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
30.77Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
30.77Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
30.77Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
30.77Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
30.77Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
30.77Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.43Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
30.43Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
30.43Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
30.43Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
30.43Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
30.43Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
30.43Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
30.43Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
30.43Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
30.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
30.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
30.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
30.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
30.00Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
30.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
30.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
30.00Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
30.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
30.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
30.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
30.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
29.63Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
29.63Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
29.63Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
29.63Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
29.63Single7XN9L-054,5227XN9-SST2-L-054,522
29.63Single8QJ2pN1628QJ2-MC4-pN162-Gs
29.63Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
29.63Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
29.63Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
29.63Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
29.63Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single6IGKEndothelin-36IGK-ETB-Endothelin-3
29.41Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
29.41Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
29.17Single5N2SPSB365N2S-A1-PSB36
29.17Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
29.17Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
29.17Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
29.17Single8JXSPF-61428JXS-D1-PF-6142
29.17Single8QOTNanobody-E8QOT-μ-Nanobody-E
29.17Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
29.03Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
29.03Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
29.03Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
29.03Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
29.03Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
29.03Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
29.03Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
29.03Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
28.57Single4IARErgotamine4IAR-5-HT1B-Ergotamine
28.57Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
28.57Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
28.57Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
28.57Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
28.57Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
28.57Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
28.57Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
28.57Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.57Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.57Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
28.57Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
28.12Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
28.12Single7SK3CXCL127SK3-ACKR3-CXCL12
28.12Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
28.12Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
28.12Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
28.12Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
28.00Single6OS1TRV0266OS1-AT1-TRV026
28.00Single7R0CAVP7R0C-V2-AVP-Arrestin2
28.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
28.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.00Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
28.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
28.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
28.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
28.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
28.00Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.00Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
28.00Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.00Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
28.00Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
28.00Consensuslpa_onOrthosteric Ligandlpa1_on
28.00Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
28.00Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
27.59Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
27.59Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
27.59Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
27.59Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
27.59Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
27.59Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Single8IEBA1LYA8IEB-GPR156-A1LYA
27.59Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
27.59Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
27.59Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
27.59Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
27.59Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
27.59Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
27.27Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
27.27Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
27.27Single8GNGIstradefylline8GNG-A2A-Istradefylline
27.27Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
27.27Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
27.27Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
27.27Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
26.92Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
26.92Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
26.92Single4RWADIPP-NH24RWA-δ-DIPP-NH2
26.92Single6MXTSalmeterol6MXT-β2-Salmeterol
26.92Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
26.92Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
26.92Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
26.92Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
26.92Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
26.92Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
26.92Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
26.92Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
26.92Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
26.92Single8JJLOlodaterol8JJL-β2-Olodaterol
26.92Single8XQJJN2418XQJ-Apelin-JN241
26.92Single8XWACXCL18XWA-CXCR2-CXCL1
26.92Single8XWMCXCL68XWM-CXCR2-CXCL6
26.92Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
26.92Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
26.92Consensusalpha1_offOrthosteric Ligandalpha1a_off
26.92Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
26.92Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
26.92Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
26.92Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
26.92Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
26.92Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
26.67Single3OE0CVX153OE0-CXCR4-CVX15
26.67Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
26.67Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
26.67Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
26.67Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
26.67Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
26.67Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
26.67Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
26.47Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
26.09Single6MH8ZM-2413856MH8-A2A-ZM-241385
26.09Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
26.09Single7AROLUF58337ARO-A2A-LUF5833-Na
26.09Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
26.09Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8IHKAcifran8IHK-HCA3-Acifran
26.09Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
26.09Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
26.09Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
26.09Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
26.09Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
26.09Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
26.09Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
25.93Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
25.93Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
25.93Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
25.93Single6IBLArformoterol6IBL-β1-Arformoterol
25.93Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
25.93Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
25.93Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
25.93Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
25.93Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
25.93Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
25.93Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
25.93Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.93Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
25.93Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
25.93Single8XVUCXCL28XVU-CXCR2-CXCL2
25.93Single8XWFCXCL38XWF-CXCR2-CXCL3
25.93Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
25.93Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
25.93Consensuscck_onOrthosteric Ligandccka_on cckb_on
25.93Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
25.93Consensuschemerin_onOrthosteric Ligandcml1_on
25.93Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
25.93Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
25.93Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
25.81Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
25.81Single6JODAngiotensin II6JOD-AT2-Angiotensin II
25.81Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
25.81Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
25.81Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
25.81Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
25.71Single5GLHEndothelin-15GLH-ETB-Endothelin-1
25.71Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
25.64Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
25.64Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
25.00Single2Y02Carmoterol2Y02-β1-Carmoterol
25.00Single3NY9ICI118-5513NY9-β2-ICI118-551
25.00Single5DHGC-355DHG-NOP-C-35
25.00Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
25.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
25.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
25.00Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
25.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
25.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
25.00Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
25.00Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
25.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
25.00Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
25.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
25.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
25.00Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
25.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
25.00Single8CU6LJ-45178CU6-A2A-LJ-4517
25.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
25.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
25.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
25.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
25.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
25.00Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
25.00Single8X5YAstemizole8X5Y-H1-Astemizole
25.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
25.00Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
25.00Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
25.00Single8XQJJN2418XQJ-Apelin-JN241
25.00Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
25.00Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
25.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
25.00Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
25.00Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
25.00Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
25.00Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
24.24Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
24.24Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
24.14Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
24.14Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
24.14Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
24.14Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
24.14Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
24.14Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
24.14Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
24.14Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
24.14Single8IEPA1LYA8IEP-GPR156-A1LYA
24.14Single8IEPA1LYA8IEP-GPR156-A1LYA
24.14Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
24.14Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
24.14Single8WDTphotoNECA8WDT-A2A-photoNECA
24.14Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.14Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
24.14Single8XWNCXCL88XWN-CXCR2-CXCL8
24.14Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
24.14Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.14Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
24.14Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
24.14Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
24.14Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
24.14Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
24.14Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
24.14Consensuslpl_onOrthosteric Ligands1p_on lpa_on
24.14Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
24.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
24.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
24.00Single5WIUNemonapride5WIU-D4-Nemonapride
24.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
24.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
24.00Single6Z4SSR486926Z4S-NTS1-SR48692
24.00Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
24.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
24.00Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
24.00Single7WC6LSD7WC6-5-HT2A-LSD
24.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
24.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
24.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
24.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
24.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
24.00Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
24.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
24.00Single8S4DCMF-0198S4D-Apelin-CMF-019
24.00Single8TF5Oleic acid8TF5-GPR6-Oleic acid
24.00Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
24.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
24.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
24.00Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
24.00Consensusdp_offOrthosteric Liganddp2_off
24.00Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
24.00Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
24.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
24.00Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
23.81Single3OE6IT1t3OE6-CXCR4-IT1t
23.81Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
23.81Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
23.53Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
23.53Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
23.33Single3QAKUK-4320973QAK-A2A-UK-432097
23.33Single6HLOAprepitant6HLO-NK1-Aprepitant
23.33Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
23.33Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
23.33Single7XNACYN1548067XNA-SST2-CYN154806
23.33Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
23.33Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
23.33Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
23.33Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
23.33Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
23.33Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
23.33Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
23.08Single3P0GBI1671073P0G-β2-BI167107
23.08Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
23.08Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
23.08Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
23.08Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
23.08Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
23.08Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
23.08Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
23.08Single6J21Aprepitant6J21-NK1-Aprepitant
23.08Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
23.08Single6WGTLSD6WGT-5-HT2A-LSD
23.08Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
23.08Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
23.08Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
23.08Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
23.08Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
23.08Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
23.08Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
23.08Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
23.08Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
23.08Single7TUYGSK682753A7TUY-GPR183-GSK682753A
23.08Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
23.08Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
23.08Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
23.08Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
23.08Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
23.08Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
23.08Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
23.08Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
23.08Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
23.08Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
23.08Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
23.08Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
23.08Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
23.08Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
23.08Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
23.08Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
23.08Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
23.08Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
23.08Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
23.08Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
23.08Consensusneurotensin_onOrthosteric Ligandnts1_on
23.08Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
23.08Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
23.08Consensusrelaxin_onOrthosteric Ligandrxfp4_on
23.08Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
23.08Consensustachykinin_offOrthosteric Ligandnk1_off
22.86Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
22.86Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
22.86Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single3OE9IT1t3OE9-CXCR4-IT1t
22.73Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
22.73Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
22.73Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
22.73Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
22.73Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
22.73Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
22.73Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
22.58Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
22.58Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
22.58Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
22.58Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
22.58Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
22.58Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
22.58Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
22.58Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
22.22Single4AMIBucindolol4AMI-β1-Bucindolol
22.22Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
22.22Single4PY02MeSATP4PY0-P2Y12-2MeSATP
22.22Single4XEENeurotensin4XEE-NTS1-Neurotensin
22.22Single4XESNeurotensin4XES-NTS1-Neurotensin
22.22Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
22.22Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
22.22Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
22.22Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
22.22Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
22.22Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
22.22Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
22.22Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
22.22Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
22.22Single7YITNalfurafine7YIT-κ-Nalfurafine
22.22Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
22.22Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
22.22Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
22.22Single8JJ8Formoterol8JJ8-β2-Formoterol
22.22Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
22.22Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
22.22Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
22.22Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
22.22Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
22.22Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
22.22Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
22.22Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
22.22Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
22.22Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
22.22Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
22.22Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
22.22Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
22.22Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
22.22Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
22.22Consensusbombesin_onOrthosteric Ligandbb2_on
22.22Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
22.22Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
22.22Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
22.22Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
22.22Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
22.22Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
22.22Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
22.22Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
22.22Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
22.22Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
22.22Consensusorexin_onOrthosteric Ligandox2_on
21.88Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
21.88Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
21.88Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
21.88Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
21.88Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
21.88Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.88Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.88Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
21.88Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
21.88Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
21.88Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
21.88Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
21.88Consensusvasop-oxy_onOrthosteric Ligandv2_on
21.88Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
21.74Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
21.74Single3ODUIT1t3ODU-CXCR4-IT1t
21.74Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
21.74Single5ZKQABT-4915ZKQ-PAF-ABT-491
21.74Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
21.74Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
21.74Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
21.74Single7BR3Elagolix7BR3-GnRH1-Elagolix
21.74Single7F8YDevazepide7F8Y-CCKA-Devazepide
21.74Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
21.74Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
21.74Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
21.74Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
21.74Single7XRRLemborexant7XRR-OX2-Lemborexant
21.74Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
21.74Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
21.74Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
21.74Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
21.74Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
21.74Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
21.74Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
21.74Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
21.43Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
21.43Single4BUONeurotensin4BUO-NTS1-Neurotensin
21.43Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
21.43Single6H7LDobutamine6H7L-β1-Dobutamine
21.43Single6K1QIRL25006K1Q-ETB-IRL2500
21.43Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
21.43Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
21.43Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
21.43Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
21.43Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
21.43Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
21.43Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
21.43Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
21.43Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
21.43Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
21.43Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
21.43Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
21.43Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
21.43Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
21.43Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
21.43Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
21.43Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
21.43Consensusprostanoid_offOrthosteric Ligandep_off dp_off
21.21Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
21.21Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
21.21Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.21Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
21.21Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
20.83Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
20.83Single4MBSMaraviroc4MBS-CCR5-Maraviroc
20.83Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
20.83Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
20.83Single5UVIZM-2413855UVI-A2A-ZM-241385
20.83Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
20.83Single6IQLL7458706IQL-D4-L745870
20.83Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
20.83Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
20.83Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
20.83Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
20.83Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
20.83Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
20.83Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.83Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
20.83Single7VV6C48/807VV6-MRGPRX2-C48/80
20.83Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
20.83Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
20.83Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
20.83Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
20.83Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
20.83Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
20.83Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
20.83Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
20.83Consensusgrh_offOrthosteric Ligandgnrh1_off
20.83Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
20.83Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
20.69Single5WF6UK-4320975WF6-A2A-UK-432097
20.69Single6KNMJN241-96KNM-Apelin-JN241-9
20.69Single6PT3DPI-2876PT3-δ-DPI-287
20.69Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
20.69Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
20.69Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
20.69Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
20.69Single8IEIA1LYA8IEI-GPR156-A1LYA
20.69Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
20.69Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
20.69Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
20.69Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
20.69Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
20.69Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.69Consensuskisspeptin_onOrthosteric Ligandkiss1_on
20.59Single4XT3Fractalkine4XT3-US28-Fractalkine
20.59Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
20.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
20.00Single3EMLZM-2413853EML-A2A-ZM-241385
20.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
20.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
20.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
20.00Single4QIMANTA XV4QIM-SMO-ANTA XV
20.00Single4QKX35V4QKX-β2-35V
20.00Single4XT1Fractalkine4XT1-US28-Fractalkine
20.00Single5DHHSB-6121115DHH-NOP-SB-612111
20.00Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
20.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
20.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
20.00Single5UENDU1725UEN-A1-DU172
20.00Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
20.00Single6D27CAY104716D27-DP2-CAY10471
20.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
20.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
20.00Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
20.00Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
20.00Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
20.00Single6S0LZM-2413856S0L-A2A-ZM-241385
20.00Single6TOTLemborexant6TOT-OX1-Lemborexant
20.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
20.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
20.00Single7BU7BI1671077BU7-β1-BI167107
20.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
20.00Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
20.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
20.00Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
20.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
20.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
20.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
20.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
20.00Single7UL4Alvimopan7UL4-μ-Alvimopan
20.00Single7V3ZCP559407V3Z-CB1-CP55940
20.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
20.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
20.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
20.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
20.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
20.00Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
20.00Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
20.00Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
20.00Single8IEBA1LYA8IEB-GPR156-A1LYA
20.00Single8IEIA1LYA8IEI-GPR156-A1LYA
20.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
20.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
20.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
20.00Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8WKYPG-9348WKY-MC4-PG-934
20.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
20.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
20.00Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
20.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
20.00Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
20.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
20.00Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
20.00Consensusa3_onOrthosteric Liganda3a_on
20.00Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
20.00Consensuscck_offOrthosteric Ligandccka_off
20.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
20.00Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
20.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
20.00Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
20.00Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
20.00Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
20.00Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
20.00Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
20.00Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
20.00Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.00Consensussomatostatin_offOrthosteric Ligandsst2_off
19.35Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
19.35Single7SK5CXCL127SK5-ACKR3-CXCL12
19.35Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
19.35Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
19.35Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
19.23Single4NTJAZD12834NTJ-P2Y12-AZD1283
19.23Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
19.23Single5C1MBU725C1M-μ-BU72
19.23Single5IUAQ274563485IUA-A2A-Q27456348-Na
19.23Single5N2RPSB-365N2R-A2A-PSB-36-Na
19.23Single6E67BI1671076E67-β2-BI167107-Gs (fused)
19.23Single6HLPNetupitant6HLP-NK1-Netupitant
19.23Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
19.23Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
19.23Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
19.23Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
19.23Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
19.23Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
19.23Single6S0QZM-2413856S0Q-A2A-ZM-241385
19.23Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
19.23Single6TP6Filorexant6TP6-OX1-Filorexant
19.23Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
19.23Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
19.23Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
19.23Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
19.23Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
19.23Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
19.23Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
19.23Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
19.23Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
19.23Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
19.23Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
19.23Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
19.23Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.23Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
19.23Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
19.23Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
19.23Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
19.23Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
19.23Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
19.23Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
19.23Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
19.23Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
19.23Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
19.23Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
19.23Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
19.23Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
19.23Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
19.23Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
19.23Consensusa3_on_gpOrthosteric Liganda3a_on_gp
19.23Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
19.23Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
19.23Consensusadenosine_offOrthosteric Liganda1_off a2_off
19.23Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
19.23Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
19.23Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
19.23Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
19.23Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
19.23Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
19.23Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
19.23Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
19.23Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
19.23Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
19.23Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
19.23Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
19.23Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
19.05Single3OE8IT1t3OE8-CXCR4-IT1t
19.05Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
19.05Single6TQ9SB-4081246TQ9-OX1-SB-408124
19.05Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
19.05Consensusp2y_offOrthosteric Ligandp2y1_off
18.75Single5WF5UK-4320975WF5-A2A-UK-432097
18.75Single6W25SHU91196W25-MC4-SHU9119-Ca
18.75Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
18.75Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
18.75Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
18.52Single4BV0Neurotensin4BV0-NTS1-Neurotensin
18.52Single4DJHJDTic4DJH-κ-JDTic
18.52Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
18.52Single5XRAAM115425XRA-CB1-AM11542
18.52Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
18.52Single6E59L-7607356E59-NK1-L-760735
18.52Single6H7JIsoprenaline6H7J-β1-Isoprenaline
18.52Single6J20Aprepitant6J20-NK1-Aprepitant
18.52Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
18.52Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
18.52Single7FEECP559407FEE-CB1-CP55940-ZCZ011
18.52Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
18.52Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
18.52Single7PX4PSB-21137PX4-A2A-PSB-2113
18.52Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
18.52Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
18.52Single8E0GBU728E0G-μ-BU72
18.52Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
18.52Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
18.52Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
18.52Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
18.52Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
18.52Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.52Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
18.52Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
18.52Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
18.52Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
18.52Single8XVLZibotentan8XVL-ETA-Zibotentan
18.52Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
18.52Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
18.52Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
18.52Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
18.52Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
18.52Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
18.52Consensusa2_onOrthosteric Liganda2b_on
18.52Consensusa2_on_gpOrthosteric Liganda2b_on_gp
18.52Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
18.52Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
18.52Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
18.52Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
18.52Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.52Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
18.52Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
18.52Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
18.52Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
18.52Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
18.52Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
18.52Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
18.52Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
18.18Single4XNWMRS25004XNW-P2Y1-MRS2500
18.18Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
18.18Single7WC5Psilocin7WC5-5-HT2A-Psilocin
18.18Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
18.18Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
18.18Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
18.18Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
18.18Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
18.18Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
18.18Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
18.18Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
18.18Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
18.18Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
17.86Single4LDEBI1671074LDE-β2-BI167107
17.86Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
17.86Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
17.86Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
17.86Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
17.86Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
17.86Single6KQICP559406KQI-CB1-CP55940-Org27569
17.86Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
17.86Single6YVRNTS8-136YVR-NTS1-NTS8-13
17.86Single6ZG4HTL00099366ZG4-M1-HTL0009936
17.86Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
17.86Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
17.86Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.86Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
17.86Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
17.86Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
17.86Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
17.86Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
17.86Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
17.86Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
17.86Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
17.86Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.86Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
17.86Consensuslpa_offOrthosteric Ligandlpa1_off
17.86Consensuslpl_offOrthosteric Ligands1p_off lpa_off
17.86Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
17.86Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
17.86Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
17.86Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
17.86Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.86Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
17.65Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
17.65Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
17.39Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
17.39Single6HLLCP999946HLL-NK1-CP99994
17.39Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
17.39Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
17.39Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
17.39Single6TP4ACT-4622066TP4-OX1-ACT-462206
17.39Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
17.39Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
17.39Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single7UL2SR486927UL2-NTS1-SR48692-Na
17.39Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
17.39Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
17.39Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
17.39Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
17.39Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
17.39Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
17.39Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
17.39Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
17.39Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
17.39Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
17.39Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
17.39Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
17.39Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
17.39Consensusgq_nucleotideOrthosteric Ligandgq_p2y
17.39Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
17.39Consensusneurotensin_offOrthosteric Ligandnts1_off
17.39Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
17.24Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
17.24Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
17.24Single5X93K-87945X93-ETB-K-8794
17.24Single7EZCUKA7EZC-A2A-UKA
17.24Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
17.24Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
17.24Single7UM4AS26747237UM4-5-HT5A-AS2674723
17.24Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
17.24Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
17.24Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
17.24Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
17.24Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
17.24Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.24Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
17.24Consensusendothelin_offOrthosteric Ligandetb_off
17.24Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
17.24Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
17.24Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
16.67Single3PWHZM-2413853PWH-A2A-ZM-241385
16.67Single4BWBNeurotensin4BWB-NTS1-Neurotensin
16.67Single4UG2CGS216804UG2-A2A-CGS21680
16.67Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
16.67Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
16.67Single5WS3EMPA5WS3-OX2-EMPA
16.67Single5ZTYAM102575ZTY-CB2-AM10257
16.67Single6AKXA4R6AKX-CCR5-A4R
16.67Single6AKYMaraviroc6AKY-CCR5-Maraviroc
16.67Single6B73MP11046B73-κ-MP1104
16.67Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
16.67Single6DS0Ly2660976DS0-5-HT2B-Ly266097
16.67Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
16.67Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
16.67Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
16.67Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.67Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
16.67Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
16.67Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
16.67Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
16.67Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
16.67Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
16.67Single7F8ULintitript7F8U-CCKA-Lintitript
16.67Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
16.67Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
16.67Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
16.67Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
16.67Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
16.67Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
16.67Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
16.67Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
16.67Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
16.67Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
16.67Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
16.67Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
16.67Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
16.67Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
16.67Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
16.67Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
16.67Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
16.67Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
16.67Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
16.67Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
16.67Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
16.67Consensusorexin_offOrthosteric Ligandox2_off ox1_off
16.67Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
16.67Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
16.67Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
16.67Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
16.67Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
16.22Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
16.13Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
16.13Single7QA8Peptide7QA8-STE2-Peptide
16.13Single7QA8Peptide7QA8-STE2-Peptide
16.13Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.13Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
16.13Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
16.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
16.00Single3REYXAC3REY-A2A-XAC
16.00Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
16.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
16.00Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
16.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
16.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
16.00Single5JTBZM-2413855JTB-A2A-ZM-241385
16.00Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
16.00Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
16.00Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
16.00Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
16.00Single6AQFZM-2413856AQF-A2A-ZM-241385
16.00Single6KUXRS-799486KUX-α2a-RS-79948
16.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
16.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
16.00Single6PS5S-Propranolol6PS5-β2-S-Propranolol
16.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
16.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
16.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
16.00Single6TPGEMPA6TPG-OX2-EMPA
16.00Single6V9SGTPL114036V9S-OX1-GTPL11403
16.00Single6VI4JDTic6VI4-κ-JDTic
16.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
16.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
16.00Single6ZINSR486926ZIN-NTS1-SR48692
16.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
16.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
16.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
16.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
16.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
16.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
16.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
16.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single7UL3Famotidine7UL3-H2-Famotidine
16.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
16.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
16.00Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
16.00Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
16.00Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
16.00Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
16.00Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
16.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
16.00Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
16.00Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
16.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
16.00Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
16.00Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
16.00Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
16.00Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
16.00Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
16.00Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
16.00Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
16.00Consensusa2_offOrthosteric Liganda2a_off
16.00Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
16.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
16.00Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
16.00Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
16.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
16.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
16.00Consensushca_onOrthosteric Ligandhca2_on
16.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.79Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
15.62Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
15.62Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
15.62Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.38Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
15.38Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
15.38Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
15.38Single5IU8Q274563475IU8-A2A-Q27456347-Na
15.38Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
15.38Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
15.38Single5UIGCmpd-15UIG-A2A-Cmpd-1
15.38Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
15.38Single6H7MSalbutamol6H7M-β1-Salbutamol
15.38Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
15.38Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
15.38Single6PS1Timolol6PS1-β2-Timolol
15.38Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
15.38Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
15.38Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
15.38Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
15.38Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
15.38Single7F83PF-051904577F83-Ghrelin-PF-05190457
15.38Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
15.38Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
15.38Single7PYRPSB-21157PYR-A2A-PSB-2115
15.38Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
15.38Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
15.38Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
15.38Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
15.38Single7WC7Lisuride7WC7-5-HT2A-Lisuride
15.38Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
15.38Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
15.38Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
15.38Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
15.38Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
15.38Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
15.38Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
15.38Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
15.38Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
15.38Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
15.38Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
15.38Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
15.38Single8JXRLSD8JXR-D1-LSD
15.38Single8K5DGSK2560738K5D-HCA2-GSK256073
15.38Single8T1WCVN4248T1W-GPR6-CVN424
15.38Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
15.38Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
15.38Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
15.38Single8X64Desloratadine8X64-H1-Desloratadine
15.38Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
15.38Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
15.38Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
15.38Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
15.38Single9CHXS-Carazolol9CHX-β2-S-Carazolol
15.38Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
15.38Consensus5ht5_onOrthosteric Ligand5ht5a_on
15.38Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
15.38Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
15.38Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
15.38Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
15.38Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
15.38Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
15.38Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
15.38Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
15.38Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
15.38Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
15.38Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
15.38Consensushca_on_gpOrthosteric Ligandhca2_on_gp
15.38Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
15.15Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
15.15Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.15Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
14.81Single2RH1S-Carazolol2RH1-β2-S-Carazolol
14.81Single2Y00Dobutamine2Y00-β1-Dobutamine
14.81Single2Y03Isoprenaline2Y03-β1-Isoprenaline
14.81Single5JQHS-Carazolol5JQH-β2-S-Carazolol
14.81Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
14.81Single5TVNLSD5TVN-5-HT2B-LSD
14.81Single5WQCEMPA5WQC-OX2-EMPA
14.81Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
14.81Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
14.81Single6LUQHaloperidol6LUQ-D2-Haloperidol
14.81Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
14.81Single7C4SS1P7C4S-S1P3-S1P
14.81Single7C61Ergotamine7C61-5-HT1B-Ergotamine
14.81Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
14.81Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
14.81Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
14.81Single7W41PD1762527W41-BB2-PD176252
14.81Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
14.81Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
14.81Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
14.81Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
14.81Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
14.81Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
14.81Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
14.81Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
14.81Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
14.81Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
14.81Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
14.81Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
14.81Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
14.81Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
14.81Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
14.81Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
14.81Consensusamine_offonOrthosteric Ligandamine_off amine_on
14.81Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
14.81Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
14.81Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
14.81Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
14.81Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
14.81Consensusbombesin_offOrthosteric Ligandbb2_off
14.81Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
14.81Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
14.81Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
14.81Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
14.81Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
14.81Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
14.81Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
14.81Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.81Consensustrace-amine_onOrthosteric Ligandta1_on
14.71Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
14.71Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
14.29Single2YDVNECA2YDV-A2A-NECA
14.29Single4UHRCGS216804UHR-A2A-CGS21680
14.29Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
14.29Single5D5AS-Carazolol5D5A-β2-S-Carazolol
14.29Single5D5BS-Carazolol5D5B-β2-S-Carazolol
14.29Single5G53NECA5G53-A2A-NECA-Gs
14.29Single5TZRMK86665TZR-FFA1-MK8666
14.29Single5V56TC1145V56-SMO-TC114
14.29Single5XR8AM8415XR8-CB1-AM841
14.29Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
14.29Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
14.29Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
14.29Single6TQ7SB-3348676TQ7-OX1-SB-334867
14.29Single7B6WCyclazosin7B6W-α1b-Cyclazosin
14.29Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
14.29Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
14.29Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
14.29Single7F1TMIP-1a7F1T-CCR5-MIP-1a
14.29Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
14.29Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
14.29Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
14.29Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
14.29Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
14.29Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
14.29Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
14.29Single7WC4Serotonin7WC4-5-HT2A-Serotonin
14.29Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
14.29Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
14.29Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
14.29Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
14.29Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
14.29Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
14.29Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
14.29Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
14.29Single9BJKNAM9BJK-μ-Naloxone-NAM
14.29Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
14.29Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
14.29Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
14.29Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
14.29Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
14.29Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
14.29Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
14.29Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
14.29Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
14.29Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
13.89Single6FJ3PTH6FJ3-PTH1-PTH
13.89Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
13.89Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
13.79Single3D4STimolol3D4S-β2-Timolol
13.79Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
13.79Single6A93Risperidone6A93-5-HT2A-Risperidone
13.79Single6CM4Risperidone6CM4-D2-Risperidone
13.79Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
13.79Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
13.79Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
13.79Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
13.79Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
13.79Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
13.79Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.79Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
13.79Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
13.79Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
13.79Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
13.79Single8JWY2-1188JWY-A2A-2-118
13.79Single8JWZAB9288JWZ-A2A-AB928-Na
13.79Single8XYIVUF106618XYI-CXCR3-VUF10661
13.79Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
13.79Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
13.79Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
13.79Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.79Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Single3RFMCaffeine3RFM-A2A-Caffeine
13.64Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
13.64Single8A2OTheophylline8A2O-A2A-Theophylline-Na
13.51Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
13.51Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
13.51Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
13.51Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
13.51Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
13.33Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
13.33Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
13.33Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
13.33Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
13.33Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
13.33Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
13.33Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
13.33Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
13.16Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
13.16Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
13.16Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
13.16Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
13.16Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
13.16Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
13.04Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
13.04Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
13.04Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
13.04Single6ME5Agomelatine6ME5-MT1-Agomelatine
13.04Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
13.04Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
13.04Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
13.04Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.04Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
13.04Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
13.04Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
12.90Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
12.90Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
12.82Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
12.50Single3PBLEticlopride3PBL-D3-Eticlopride
12.50Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
12.50Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
12.50Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
12.50Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
12.50Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
12.50Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
12.50Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
12.50Single7SRQLSD7SRQ-5-HT2B-LSD
12.50Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
12.50Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
12.50Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
12.50Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
12.50Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
12.50Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
12.50Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
12.50Single8K5BNiacin8K5B-HCA2-Niacin
12.50Single8KIGSHU91198KIG-MC3-SHU9119-Ca
12.50Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.50Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
12.50Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
12.20Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
12.20Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.12Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
12.12Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
12.12Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
12.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
12.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
12.00Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
12.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
12.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
12.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
12.00Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
12.00Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
12.00Single6TODEMPA6TOD-OX1-EMPA-Na
12.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
12.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
12.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
12.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
12.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
12.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
12.00Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
12.00Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.00Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
12.00Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
12.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
12.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
12.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
12.00Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
12.00Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
12.00Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.00Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
12.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
12.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
12.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
12.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
12.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
12.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
12.00Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
12.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
12.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
12.00Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.90Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
11.90Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
11.90Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
11.54Single2YDOAdenosine2YDO-A2A-Adenosine
11.54Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
11.54Single3RZECidoxepin3RZE-H1-Cidoxepin
11.54Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
11.54Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
11.54Single6A94Zotepine6A94-5-HT2A-Zotepine
11.54Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
11.54Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
11.54Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
11.54Single6PS0S-Carazolol6PS0-β2-S-Carazolol
11.54Single6PS4ICI118-5516PS4-β2-ICI118-551
11.54Single6TPKRetosiban6TPK-OT-Retosiban
11.54Single6TPNHTL66416TPN-OX2-HTL6641
11.54Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
11.54Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
11.54Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
11.54Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
11.54Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
11.54Single7VODCariprazine7VOD-5-HT2A-Cariprazine
11.54Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
11.54Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
11.54Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
11.54Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
11.54Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
11.54Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
11.54Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
11.54Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
11.54Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
11.54Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
11.54Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.54Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
11.54Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
11.54Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
11.54Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
11.54Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
11.54Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
11.54Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
11.54Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
11.54Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
11.54Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.54Single8K5CAcipimox8K5C-HCA2-Acipimox
11.54Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
11.54Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
11.54Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
11.54Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
11.54Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
11.54Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
11.54Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
11.54Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
11.54Single9BJKNaloxone9BJK-μ-Naloxone-NAM
11.54Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
11.54Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
11.54Consensusalpha1_onOrthosteric Ligandalpha1a_on
11.54Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
11.54Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
11.54Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
11.54Consensusopsins_offOrthosteric Ligandrhodopsin_off
11.54Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
11.54Consensussensory_offOrthosteric Ligandopsins_off
11.54Consensusvasop-oxy_offOrthosteric Ligandot_off
11.43Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
11.43Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
11.43Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
11.43Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
11.43Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
11.11Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
11.11Single2Y01Dobutamine2Y01-β1-Dobutamine
11.11Single2Y04Salbutamol2Y04-β1-Salbutamol
11.11Single3NY8ICI118-5513NY8-β2-ICI118-551
11.11Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
11.11Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
11.11Single4GBRS-Carazolol4GBR-β2-S-Carazolol
11.11Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
11.11Single5T04Neurotensin5T04-NTS1-Neurotensin
11.11Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
11.11Single6DRXLisuride6DRX-5-HT2B-Lisuride
11.11Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
11.11Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
11.11Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
11.11Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
11.11Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
11.11Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
11.11Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
11.11Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
11.11Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
11.11Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
11.11Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
11.11Single7YXAONO-54306087YXA-S1P5-ONO-5430608
11.11Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
11.11Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
11.11Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
11.11Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
11.11Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
11.11Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
11.11Single8JJOAlprenolol8JJO-β2-Alprenolol
11.11Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
11.11Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
11.11Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
11.11Single8RLNLUF58348RLN-A2A-LUF5834
11.11Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
11.11Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
11.11Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
11.11Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
11.11Single8X63Mepyramine8X63-H1-Mepyramine
11.11Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
11.11Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
11.11Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
11.11Single9IYAONO-97105319IYA-GPR55-ONO-9710531
11.11Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
11.11Consensusalpha2_onOrthosteric Ligandalpha2b_on
11.11Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
11.11Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
11.11Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
11.11Consensusdopamine_offOrthosteric Ligandd2_off d3_off
11.11Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
11.11Consensushistamine_offOrthosteric Ligandh1_off
10.81Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
10.81Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
10.81Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
10.81Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
10.81Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
10.81Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
10.81Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
10.81Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
10.71Single2YCWS-Carazolol2YCW-β1-S-Carazolol
10.71Single4JKVTaladegib4JKV-SMO-Taladegib
10.71Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
10.71Single5D6LS-Carazolol5D6L-β2-S-Carazolol
10.71Single5XPRBosentan5XPR-ETB-Bosentan
10.71Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
10.71Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
10.71Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
10.71Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
10.71Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
10.71Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
10.71Single7SINNPS-21437SIN-CaS-NPS-2143
10.71Single7SINNPS-21437SIN-CaS-NPS-2143
10.71Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
10.71Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.71Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
10.71Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
10.71Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
10.71Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
10.71Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
10.71Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
10.71Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
10.71Consensusep_offOrthosteric Ligandep4_off
10.53Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
10.53Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
10.53Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
10.53Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
10.53Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
10.53Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
10.34Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
10.34Single4U15Tiotropium4U15-M3-Tiotropium
10.34Single5V54Methiothepin5V54-5-HT1B-Methiothepin
10.34Single5V57TC1145V57-SMO-TC114
10.34Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
10.34Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
10.34Single6OL9Tiotropium6OL9-M5-Tiotropium
10.34Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
10.34Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
10.34Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
10.34Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
10.34Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
10.34Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
10.34Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
10.34Consensus5ht1_offOrthosteric Ligand5ht1b_off
10.34Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
10.34Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
10.34Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
10.34Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
10.26Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
10.26Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
10.26Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
10.26Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
10.26Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
10.26Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
10.00Single4N4WSANT-14N4W-SMO-SANT-1
10.00Single5CXVTiotropium5CXV-M1-Tiotropium
10.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
10.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
10.00Single7DFPSpiperone7DFP-D2-Spiperone
10.00Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
10.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
10.00Single7K15MKD0467K15-BLT1-MKD046-Na
10.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
10.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
10.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
10.00Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
10.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
10.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
9.76Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
9.68Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
9.68Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
9.68Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
9.68Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
9.68Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
9.68Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single8XVJMacitentan8XVJ-ETA-Macitentan
9.68Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
9.52Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
9.52Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
9.52Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
9.52Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
9.52Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
9.52Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
9.52Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single5EE7MK08935EE7-Glucagon-MK0893
9.38Single7SK9CCX6627SK9-ACKR3-CCX662
9.09Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
9.09Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
9.09Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
9.09Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
9.09Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
9.09Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
9.09Single8PWNTheophylline8PWN-A2A-Theophylline
9.09Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
8.82Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
8.70Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
8.70Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
8.70Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
8.70Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
8.70Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
8.70Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
8.70Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
8.70Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
8.70Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
8.70Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
8.70Consensussensory_onOrthosteric Ligandopsins_on
8.57Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
8.33Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
8.33Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
8.33Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
8.33Single3UZAGTPL92363UZA-A2A-GTPL9236
8.33Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
8.33Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
8.33Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
8.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.33Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
8.33Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
8.33Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
8.33Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
8.33Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
8.33Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
8.33Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.33Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.33Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
8.33Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
8.33Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
8.33Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
8.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
8.33Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
8.33Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
8.33Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
8.33Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
8.33Consensus5ht2_onOrthosteric Ligand5ht2b_on
8.33Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.33Consensusgi_sensoryOrthosteric Ligandgi_opsins
8.33Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
8.33Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.33Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
8.33Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
8.33Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
8.33Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
8.11Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
8.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
8.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
8.00Single5L7IVismodegib5L7I-SMO-Vismodegib
8.00Single6LI0C176LI0-GPR52-C17
8.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
8.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
8.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
8.00Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
8.00Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
8.00Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
8.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
8.00Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
8.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
8.00Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
8.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
8.00Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
8.00Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.00Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
8.00Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
8.00Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
8.00Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
8.00Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
8.00Single9B9Y7DY9B9Y-CB1-7DY
8.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
7.89Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
7.89Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
7.89Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
7.69Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
7.69Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
7.69Single4QINSAG1.54QIN-SMO-SAG1.5
7.69Single4XNVBPTU4XNV-P2Y1-BPTU
7.69Single5U09Taranabant5U09-CB1-Taranabant
7.69Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
7.69Single6ME2Ramelteon6ME2-MT1-Ramelteon
7.69Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
7.69Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
7.69Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
7.69Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
7.69Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.69Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
7.69Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
7.69Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
7.69Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
7.69Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
7.69Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
7.69Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
7.69Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
7.69Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
7.69Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
7.69Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
7.69Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
7.69Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
7.69Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
7.69Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
7.69Single8Y0HVUF114188Y0H-CXCR3-VUF11418
7.69Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
7.69Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.69Single9BA0A1AKN9BA0-CB1-A1AKN
7.69Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
7.69Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
7.69Consensusalpha2_offOrthosteric Ligandalpha2c_off
7.69Consensusangiotensin_offOrthosteric Ligandat1_off
7.69Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
7.69Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
7.69Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
7.69Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
7.69Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
7.69Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
7.69Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
7.69Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
7.69Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
7.50Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
7.50Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
7.41Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
7.41Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
7.41Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
7.41Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
7.41Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
7.41Single7T32ZM-2413857T32-A2A-ZM-241385
7.41Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
7.41Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
7.41Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
7.41Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
7.41Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
7.41Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
7.41Single8K2WAMG4878K2W-CXCR3-AMG487
7.41Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
7.41Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
7.41Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.41Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
7.41Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
7.41Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
7.41Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
7.41Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
7.41Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
7.41Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
7.14Single4DAJTiotropium4DAJ-M3-Tiotropium
7.14Single4MQSIperoxo4MQS-M2-Iperoxo
7.14Single4U14Tiotropium4U14-M3-Tiotropium
7.14Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
7.14Single4YAYZD-71554YAY-AT1-ZD-7155
7.14Single5TGZAM65385TGZ-CB1-AM6538
7.14Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
7.14Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
7.14Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
7.14Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
7.14Single6GPSMK08126GPS-CCR2-MK0812
7.14Single6IIVDaltroban6IIV-TP-Daltroban
7.14Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
7.14Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
7.14Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
7.14Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
7.14Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
7.14Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
7.14Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
7.14Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
7.14Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
7.14Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
7.14Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
7.14Single9B9ZA1AKO9B9Z-CB1-A1AKO
7.14Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
7.14Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
7.14Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
7.14Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
7.14Consensusblt_onOrthosteric Ligandblt1_on
7.14Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
7.14Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
7.14Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
7.14Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
7.14Consensusleukotriene_onOrthosteric Ligandblt_on
7.14Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
7.14Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
7.14Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
6.90Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
6.90Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
6.90Single6GPXMK08126GPX-CCR2-MK0812
6.90Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
6.90Single6PS6Timolol6PS6-β2-Timolol
6.90Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
6.90Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
6.90Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
6.90Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.90Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
6.90Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
6.90Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
6.90Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
6.90Single8ZMFA1L108ZMF-5-HT2C-A1L10
6.90Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
6.90Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
6.90Consensusblt_offOrthosteric Ligandblt1_off
6.90Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
6.90Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.90Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.82Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
6.82Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
6.82Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
6.82Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
6.67Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
6.67Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
6.67Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
6.67Single8EA0Iperoxo8EA0-M3-Iperoxo
6.67Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
6.67Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
6.67Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
6.67Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
6.67Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
6.67Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
6.45Single5X33BIIL2605X33-BLT1-BIIL260
6.45Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
6.45Single6IIURamatroban6IIU-TP-Ramatroban
6.45Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
6.45Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
6.45Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
6.45Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
6.45Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
6.25Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
6.25Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
6.25Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
6.25Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
6.25Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
6.25Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
6.12Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
6.06Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
6.06Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
6.06Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
6.06Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
5.88Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
5.71Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
5.56Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
5.41Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
5.41Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
5.41Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
5.41Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
5.26Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
5.00Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
5.00Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
4.88Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
4.76Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
4.76Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.55Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
4.55Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
4.55Single5MZPCaffeine5MZP-A2A-Caffeine-Na
4.55Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
4.35Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.35Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.17Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
4.17Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
4.17Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
4.17Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
4.17Single9CHUNoradrenaline9CHU-β2-Noradrenaline
4.00Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
4.00Single8JPSCCL78JPS-ACKR1-CCL7
4.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
4.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
4.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
4.00Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
4.00Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
4.00Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
3.85Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
3.85Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
3.85Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
3.85Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
3.85Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
3.85Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
3.85Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
3.85Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
3.85Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
3.85Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
3.70Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
3.70Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
3.70Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
3.70Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
3.70Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
3.70Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
3.70Single7WV9ZCZ0117WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
3.70Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
3.70Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
3.70Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
3.70Single8IWESpermidine8IWE-TA9-Spermidine
3.70Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
3.70Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
3.70Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
3.70Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
3.70Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
3.57Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.57Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
3.45Single5DSGTiotropium5DSG-M4-Tiotropium
3.45Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
3.45Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
3.45Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
3.33Single5CGCHTL142425CGC-mGlu5-HTL14242
3.33Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
3.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.33Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
3.33Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
3.33Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
3.33Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
3.33Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
3.23Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
3.23Single7P2L4YI7P2L-mGlu5-4YI
3.23Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
3.23Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
3.23Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
3.12Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
3.03Single5CGDHTL142425CGD-mGlu5-HTL14242
2.94Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
2.86Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
2.56Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
2.44Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
2.38Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2

Consensus Members
Id Members
8K6M 8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
Net Summary
Imin 1.24
Number of Linked Nodes 853
Number of Links 1298
Number of Hubs 300
Number of Links mediated by Hubs 1000
Number of Communities 24
Number of Nodes involved in Communities 454
Number of Links involved in Communities 748
Path Summary
Number Of Nodes in MetaPath 79
Number Of Links MetaPath 78
Number of Shortest Paths 19239365
Length Of Smallest Path 3
Average Path Length 46.954
Length of Longest Path 59
Minimum Path Strength 1.24
Average Path Strength 4.19039
Maximum Path Strength 18.905
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.38095
Average % Of Corr. Nodes 30.3756
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 82.9211
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
npy1_off_on_gpnpy1_on_gpnpy1_off
This network is also present in following consensuses:
IdComponents
npy_on_gpnpy1_on_gp
npy2_on_gp
npy4_on_gp



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Download npy1_on_gp.zip



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