Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x31 0.672917405
21x50 5.66417409
31x57 6.22933538
41x60 3.67233507
52x40 4.31875439
62x41 4.689536
72x42 4.67333408
82x43 4.62533538
92x46 3.33333439
102x50 6.196539
112x51 2.905675178
122x55 3.34254176
132x57 3.90833428
142x60 7.299527
152x63 4.94467526
162x65 2.65433506
17E1x52 4.40125406
183x33 8.10233528
193x37 3.41733528
203x46 3.59458439
213x50 3.7075439
223x51 7.128334159
234x50 6.110834189
244x54 2.630834195
254x56 2.96625427
264x57 4.67472628
27E2 6.085881725
28E2x52 7.04708427
295x38 6.20958424
305x39 4.4275428
315x46 5.5575427
325x57 6.039335157
336x29 3.31333407
346x33 2.955538
356x48 6.19417829
366x51 7.05778627
376x55 3.76833427
38E3 4.02037923
397x34 5.946525
407x38 9.835426
417x39 4.94694628
427x42 6.97021828
437x47 2.41083406
447x49 6.11125439
457x53 4.94667539
468x47 4.15567539
478x50 4.53833538
48G.HN.11 2.93033502
49G.S1.02 4.75433585
50G.S1.04 2.81708487
51G.S1.05 4.26333419
52G.S1.06 3.743334208
53G.H1.01 3.341674209
54G.S2.03 5.77833419
55G.S2.06 5.43292409
56G.S2.08 6.74375485
57G.S3.01 3.88625484
58G.S3.03 6.54133587
59G.S3.04 8.60583416
60G.S3.06 7.033515
61G.S3.07 3.003334209
62G.S3.08 3.82625419
63G.s3h2.03 3.09417419
64G.H2.02 3.55292418
65G.H2.03 5.729519
66G.H2.06 4.97111619
67G.H2.07 4.56278619
68G.h2s4.01 5.16367519
69G.S4.04 5.66167479
70G.S4.06 3.68042407
71G.s4h3.01 4.30875477
72G.s4h3.04 5.34979878
73G.s4h3.15 4.29792409
74G.H3.01 6.387084229
75G.H3.09 4.80806679
76G.H3.17 5.90611605
77G.H3.18 6.192084219
78G.S5.03 2.9425408
79G.S5.04 3.65375479
80G.S5.05 3.436946149
81G.S5.06 4.66792478
82G.S5.07 3.3825409
83G.HG.04 5.39833479
84G.HG.13 2.86477
85G.HG.15 3.78042407
86G.hgh4.02 5.3655237
87G.hgh4.05 7.05708407
88G.H4.03 6.71133504
89G.H4.15 3.70067508
90G.S6.02 4.96533507
91G.S6.05 4.10667474
92G.s6h5.01 4.823334149
93G.s6h5.05 2.925149
94G.H5.03 4.5365148
95G.H5.08 4.97667488
96G.H5.25 3.21333437
97b.1x15 3.64875444
98b.1x16 3.019542
99b.1x19 3.82917442
100b.lhb1x3 2.609675102
101b.lhb1x6 3.884335103
102b.lhb1x11 3.72208494
103b.l1x3 7.33583669
104b.b2x1 6.23933518
105b.b2x5 5.953066117
106b.l3x2 4.27333569
107b.b4x3 2.86754167
108b.b4x4 7.31458468
109b.b4x6 8.23917669
110b.b5x2 5.60583407
111b.b5x3 5.43619769
112b.b5x5 4.80417405
113b.b5x7 4.10458407
114b.l5x1 3.3045168
115b.l5x5 5.52905719
116b.b6x5 3.53367506
117b.l6x5 5.19414
118b.b7x1 6.49083414
119b.l7x2 3.788519
120b.b8x3 3.04583416
121b.b8x4 4.6745166
122b.l8x3 2.68375403
123b.b9x4 4.56567509
124b.l9x3 6.235619
125b.l9x6 3.79907918
126b.b10x5 3.38738719
127b.l10x1 3.82167403
128b.b11x4 5.69083419
129b.l11x2 6.302519
130b.b12x6 8.69778618
131b.l12x1 3.34708416
132b.b13x7 7.75367557
133b.l13x3 6.70472659
134b.l13x6 5.79667519
135b.l13x7 4.17375459
136b.b14x3 3.89792455
137b.b15x1 6.435459
138b.b15x2 4.68542446
139b.b15x3 3.92042459
140b.l15x1 4.29167517
141b.l15x2 5.02767559
142b.b16x4 9.86542456
143b.b16x5 3.38333505
144b.b16x6 9.03867558
145b.b16x7 4.72292409
146b.b17x5 6.00542447
147b.b17x7 6.36458448
148b.l17x3 8.83222649
149b.l17x6 5.61233519
150b.b18x3 4.60458448
151b.b18x5 4.49167405
152b.l18x1 5.423337126
153b.l18x2 5.448334127
154b.b19x2 5.94222646
155b.b19x4 4.728548
156b.l19x2 7.26625449
157b.b20x4 9.44333548
158b.b20x6 6.97067546
159b.b21x1 6.212547
160b.b21x2 2.46708406
161b.b21x5 4.34542404
162b.b21x7 4.4825605
163b.l21x5 3.324134
164b.b22x5 4.4655127
165b.l22x5 7.2195109
166b.b23x1 3.59125405
167b.b23x6 5.669176137
168b.l23x1 8.16875406
169b.l23x2 4.000424138
170b.b24x4 5.1015136
171b.b24x6 5.514174138
172b.l24x3 3.5225405
173b.b25x3 3.174135
174b.b25x7 5.96375497
175b.l25x3 7.976599
176b.l25x7 3.05083497
177b.b26x3 3.59917406
178b.l27x1 10.6269619
179b.b28x3 3.1625467
180b.b28x4 5.96917496
181b.b28x6 7.43833599
182g.h2x9 2.11542404
183g.h2x11 6.68254126
184g.ctx3 5.33028609
185g.ctx6 4.2285106
186g.ctx14 3.57233509
187g.ctx15 5.8425469
188g.ctx16 4.23952768
189Lig 8.552581120
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
16x48 Lig 32.26712.55167YesYes290
26x48 7x45 40.84438.66333YesNo099
37x45 7x49 41.502710.4433NoYes099
43x43 7x49 44.74675.19167NoYes399
53x43 7x53 51.58088.05833NoYes399
62x43 7x53 11.75972.99333YesYes389
72x43 8x50 13.27026.04167YesYes388
83x33 E2 11.30213.435YesYes285
93x50 7x53 65.3385.14333YesYes399
103x50 G.H5.25 80.9814.85833YesYes397
116x33 G.H5.25 81.38732.34167YesYes387
126x33 G.H5.26 89.04122.57667YesNo080
136x29 G.H5.26 89.46825.34333YesNo070
146x29 G.H5.17 91.18192.89YesNo075
15G.H5.13 G.H5.17 45.70475.99167NoNo085
16G.H5.13 G.S6.02 46.12693.83333NoYes087
17G.H5.10 G.S6.02 92.53845.115NoYes067
18G.H5.10 G.S5.03 92.64083.25NoYes068
19G.H5.17 G.h4s6.12 45.69365.4NoNo054
20G.S6.02 G.h4s6.12 45.799910.4767YesNo074
21G.S5.03 G.S5.05 98.11813.34833YesYes089
22G.S5.05 G.s6h5.01 49.24115.18833YesYes1499
23G.s6h5.01 G.s6h5.05 50.13622.65YesYes1499
24G.H5.02 G.s6h5.05 99.77265.07NoYes049
25G.H5.02 G.s6h5.02 99.81052.965NoNo047
26G.HG.01 G.s6h5.02 99.83172.965NoNo2457
27G.H4.03 G.HG.01 99.9246.57YesNo045
28G.H4.03 G.HG.04 50.4524.985YesYes049
29G.HG.04 G.s4h3.01 50.13334.06167YesYes797
30G.S5.06 G.s4h3.01 49.77756.69167YesYes787
31G.S4.06 G.S5.06 49.4092.48333YesYes078
32G.S4.04 G.S4.06 49.85463.275YesYes097
33G.H3.08 G.S4.04 1005.07333NoYes099
34G.H3.08 G.H3.12 99.94532.85333NoNo098
35G.H3.12 G.S1.07 99.89063.56667NoNo089
36G.S1.05 G.S1.07 99.83585.075YesNo099
37G.S1.05 G.h2s4.01 62.08367.50833YesYes199
38G.h2s4.01 b.l5x5 23.69866.34833YesYes199
39b.l3x1 b.l5x5 23.354.565NoYes199
40b.b2x1 b.l3x1 23.209814.4667YesNo189
41b.b2x1 b.l27x1 22.8644.66YesYes189
42b.b26x1 b.l27x1 11.8814.94167NoYes099
43b.b26x1 b.b26x2 11.81492.86667NoNo097
44b.b26x2 b.b2x3 11.74945.13NoNo076
45b.b2x3 b.b2x5 11.61423.10333NoYes1167
46G.H5.03 G.S5.05 49.1443.22333YesYes1489
47G.H5.03 G.s6h5.05 49.48484.71167YesYes1489
48G.H4.03 G.H4.07 49.53973.11167YesNo045
49G.H4.07 G.S6.05 49.54973.00167NoYes054
50G.S5.06 G.S6.05 49.516.49667YesYes784
51G.S5.04 G.S5.06 49.87213YesYes798
52G.S4.04 G.S5.04 49.36123.045YesYes799
53G.S1.05 G.S3.08 37.64272.73167YesYes199
54G.H2.07 G.S3.08 37.44357.35667YesYes199
55G.H2.07 b.l9x6 50.90972.89333YesYes198
56b.l11x1 b.l9x6 48.44133.865NoYes198
57b.b11x6 b.l11x1 48.3393.09333NoNo199
58G.H2.07 G.h2s4.01 37.45993.84167YesYes199
59G.H2.04 G.H2.07 23.80714.33333NoYes099
60G.H2.04 G.H2.08 23.53683.34167NoNo098
61G.H2.08 G.H3.17 22.85612.545NoYes085
62G.H3.17 b.l25x6 22.16582.66667YesNo058
63b.l25x6 b.l27x1 11.16817.825NoYes089
64b.b11x6 b.l9x3 46.811215.3433NoYes199
65b.b11x4 b.l9x3 42.26375.70833YesYes199
66b.b11x4 b.b8x1 42.1492.81667YesNo098
67b.b10x3 b.b8x1 42.12082.42667NoNo088
68b.b10x3 b.b6x2 41.98683.66167NoNo088
69b.b10x2 b.b6x2 41.85323.09833NoNo068
70b.b10x2 b.b14x3 41.724.76167NoYes065
71b.b11x3 b.b14x3 37.36692.73167NoYes555
72b.b11x3 b.l10x1 37.39952.73167NoYes053
73b.b11x1 b.l10x1 37.36523.10333NoYes053
74b.b11x1 b.l16x2 36.39433.69833NoNo059
75b.l14x5 b.l16x2 36.25555.51NoNo059
76b.b16x7 b.l14x5 31.17862.38167YesNo095
77b.b16x7 b.l14x6 15.3093.84333YesNo093
78b.b16x5 b.l14x6 15.16892.99833YesNo053
79b.b16x5 b.b17x5 16.79243.325YesYes057
80b.b17x5 b.b21x1 13.404910.0083YesYes477
81b.1x19 b.b21x1 12.01224.36667YesYes427
82b.b16x7 b.b17x4 15.45025.955YesNo095
83b.b16x5 b.b17x4 15.17093.035YesNo055
84b.l23x1 b.l25x6 33.092720.25YesNo068
85b.l21x7 b.l23x1 16.66676.22NoYes056
86b.l21x7 b.l23x2 16.24335.70333NoYes058
87b.b23x6 b.l23x2 14.12153.45YesYes1378
88b.b23x6 b.b24x6 11.7975.46667YesYes1378
89b.b21x7 b.b24x6 10.75915.78833YesYes058
90b.b22x1 b.l23x1 16.04293.13333NoYes086
91b.b22x1 b.b22x2 15.83422.66667NoNo088
92b.b22x2 b.b26x3 15.63145.255NoYes086
933x33 Lig 12.847613.8317YesYes280
942x43 3x46 11.68426.33667YesYes389
953x46 3x50 15.20862.505YesYes399
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x537x422.6550NoYes8821
2x563x328.656672NoNo8821
2x567x423.5252NoYes8821
2x577x392.346672YesYes8822
2x577x424.501672YesYes8821
2x607x389.113332YesYes7621
2x607x393.2152YesYes7822
2x607x424.821672YesYes7821
3x327x4210.7952NoYes8811
3x32Lig8.301672NoYes8010
3x334x5712.922YesYes8811
3x334x625.238332YesNo8712
3x33E2x525.086672YesYes8712
3x33E23.4352YesYes8512
3x33Lig13.83172YesYes8010
3x366x482.611672NoYes8911
3x36Lig6.083332NoYes8010
3x373x415.453332YesNo8712
3x374x533.362YesNo8812
3x374x562.343332YesYes8712
3x374x573.341672YesYes8811
3x37Lig2.588332YesYes8010
3x406x443.522NoNo8922
3x406x486.983332NoYes8921
3x414x562.728332NoYes7722
4x564x574.128332YesYes7821
4x565x462.6652YesYes7721
4x575x432.838332YesNo8812
4x57Lig2.952YesYes8010
E2E2x5215.33172YesYes5722
6x55E23.0252YesYes7522
5x466x486.358332YesYes7911
5x46Lig10.97332YesYes7010
5x476x483.340NoYes9921
6x446x486.182NoYes9921
6x487x4112.8652YesNo9811
6x487x458.663332YesNo9912
6x48Lig2.551672YesYes9010
6x516x556.6252YesYes7712
6x517x347.1152YesYes7512
6x517x374.373332YesNo7512
6x517x387.3952YesYes7611
6x517x418.131672YesNo7811
6x51Lig8.706672YesYes7010
6x557x342.496672YesYes7522
7x387x427.351672YesYes6811
7x38Lig15.482YesYes6010
7x397x4210.77832YesYes8821
7x41Lig11.27832NoYes8010
7x42Lig11.33332YesYes8010
E2E213.00332YesYes5522
5x455x462.233330NoYes4721
4x575x4611.872YesNo8012

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
84.62Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
83.33Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
83.33Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
81.82Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
81.82Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
81.82Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
81.82Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
81.82Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
81.82Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
81.82Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
78.57Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
76.92Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
76.92Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
76.92Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
76.92Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
75.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
75.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
75.00Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
72.73Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
72.73Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
72.73Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
72.73Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
71.43Single4U15Tiotropium4U15-M3-Tiotropium
71.43Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
71.43Single6OL9Tiotropium6OL9-M5-Tiotropium
71.43Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
71.43Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
71.43Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
71.43Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
71.43Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
71.43Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
69.23Single4MQSIperoxo4MQS-M2-Iperoxo
69.23Single4U14Tiotropium4U14-M3-Tiotropium
69.23Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
69.23Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
69.23Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
69.23Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
69.23Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
66.67Single5CXVTiotropium5CXV-M1-Tiotropium
66.67Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
66.67Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
66.67Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
66.67Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
66.67Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
64.29Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
64.29Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
64.29Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
63.64Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
63.64Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
63.64Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
63.64Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
63.64Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
62.50Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
62.50Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
62.50Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
61.54Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
61.54Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
61.54Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
60.00Single8EA0Iperoxo8EA0-M3-Iperoxo
60.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
60.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
58.33Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
58.33Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
58.33Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
58.33Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
58.33Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
57.14Single4DAJTiotropium4DAJ-M3-Tiotropium
57.14Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
57.14Single5DSGTiotropium5DSG-M4-Tiotropium
57.14Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
57.14Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
57.14Consensusalpha2_onOrthosteric Ligandalpha2b_on
57.14Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
57.14Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
57.14Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
57.14Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
56.25Single6ZG4HTL00099366ZG4-M1-HTL0009936
56.25Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
56.25Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
56.25Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
54.55Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
54.55Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
53.85Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
53.85Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
53.85Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
53.85Single8IWESpermidine8IWE-TA9-Spermidine
53.85Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
53.85Single8Y0HVUF114188Y0H-CXCR3-VUF11418
53.85Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
53.85Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
53.85Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
53.33Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
53.33Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
53.33Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
53.33Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
53.33Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
53.33Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
50.00Single2YDOAdenosine2YDO-A2A-Adenosine
50.00Single2YDVNECA2YDV-A2A-NECA
50.00Single3RZECidoxepin3RZE-H1-Cidoxepin
50.00Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
50.00Single4UHRCGS216804UHR-A2A-CGS21680
50.00Single5G53NECA5G53-A2A-NECA-Gs
50.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
50.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
50.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
50.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
50.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
50.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
50.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
50.00Single7SK9CCX6627SK9-ACKR3-CCX662
50.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
50.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
50.00Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
50.00Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
50.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
50.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
50.00Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
50.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
50.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
50.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
50.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
50.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
50.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
50.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
50.00Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
50.00Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
50.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
50.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
50.00Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
50.00Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
50.00Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
50.00Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
50.00Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
50.00Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
47.06Single3D4STimolol3D4S-β2-Timolol
47.06Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
47.06Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
47.06Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
47.06Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
47.06Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
47.06Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
46.67Single3NY8ICI118-5513NY8-β2-ICI118-551
46.67Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
46.67Single4EJ4Naltrindole4EJ4-δ-Naltrindole
46.67Single4GBRS-Carazolol4GBR-β2-S-Carazolol
46.67Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
46.67Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
46.67Single8JJOAlprenolol8JJO-β2-Alprenolol
46.67Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
46.67Single8JXRLSD8JXR-D1-LSD
46.67Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
46.67Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
46.67Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
46.67Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
46.67Single8X63Mepyramine8X63-H1-Mepyramine
46.67Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
46.67Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
46.67Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
46.67Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
46.67Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
46.67Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
46.67Consensusdopamine_offOrthosteric Ligandd2_off d3_off
46.67Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
46.67Consensushistamine_offOrthosteric Ligandh1_off
46.15Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
46.15Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
46.15Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
46.15Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
46.15Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
46.15Single7SRQLSD7SRQ-5-HT2B-LSD
46.15Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
46.15Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
46.15Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
46.15Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
46.15Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
44.44Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
44.44Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
44.44Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
44.44Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
44.44Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
44.44Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
44.44Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
44.44Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
44.44Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
43.75Single2RH1S-Carazolol2RH1-β2-S-Carazolol
43.75Single2YCWS-Carazolol2YCW-β1-S-Carazolol
43.75Single5D6LS-Carazolol5D6L-β2-S-Carazolol
43.75Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
43.75Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
43.75Single6PS6Timolol6PS6-β2-Timolol
43.75Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
43.75Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
43.75Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
43.75Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
43.75Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
43.75Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
43.75Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
43.75Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
43.75Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
43.75Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
43.75Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
43.75Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
43.75Consensusamine_offonOrthosteric Ligandamine_off amine_on
43.75Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
43.75Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
43.75Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
43.75Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
43.75Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
43.75Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
43.75Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
43.75Consensustrace-amine_onOrthosteric Ligandta1_on
42.86Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
42.86Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
42.86Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
42.86Single5WF5UK-4320975WF5-A2A-UK-432097
42.86Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
42.86Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
42.86Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
42.86Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
42.86Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
42.86Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
42.86Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
42.86Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
42.86Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
42.86Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
42.86Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
42.86Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
42.86Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
42.86Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
42.86Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
42.86Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
42.86Consensusalpha2_offOrthosteric Ligandalpha2c_off
42.86Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
42.86Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
42.86Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
42.11Single4UG2CGS216804UG2-A2A-CGS21680
42.11Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
41.67Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
41.67Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
41.67Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
41.67Single9CHUNoradrenaline9CHU-β2-Noradrenaline
41.18Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
41.18Single5D5AS-Carazolol5D5A-β2-S-Carazolol
41.18Single5D5BS-Carazolol5D5B-β2-S-Carazolol
41.18Single5V54Methiothepin5V54-5-HT1B-Methiothepin
41.18Single6TQ7SB-3348676TQ7-OX1-SB-334867
41.18Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
41.18Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
41.18Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
41.18Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
41.18Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
41.18Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
41.18Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
41.18Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
41.18Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
41.18Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
41.18Consensus5ht1_offOrthosteric Ligand5ht1b_off
41.18Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
41.18Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
41.18Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
40.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
40.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
40.00Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
40.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
40.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
40.00Single6PS0S-Carazolol6PS0-β2-S-Carazolol
40.00Single6PS4ICI118-5516PS4-β2-ICI118-551
40.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
40.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
40.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
40.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
40.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
40.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
40.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
40.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
40.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
40.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Single7UL3Famotidine7UL3-H2-Famotidine
40.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
40.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
40.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
40.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
40.00Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
40.00Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
40.00Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
40.00Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
40.00Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
40.00Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
40.00Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
40.00Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
40.00Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
40.00Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
40.00Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
40.00Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
40.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
40.00Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
40.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
40.00Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
40.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
40.00Single8WDTphotoNECA8WDT-A2A-photoNECA
40.00Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
40.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
40.00Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
40.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
40.00Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
40.00Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
40.00Consensusopsins_offOrthosteric Ligandrhodopsin_off
40.00Consensussensory_offOrthosteric Ligandopsins_off
38.89Single4AMIBucindolol4AMI-β1-Bucindolol
38.89Single6A93Risperidone6A93-5-HT2A-Risperidone
38.89Single6CM4Risperidone6CM4-D2-Risperidone
38.89Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
38.89Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
38.89Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
38.89Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
38.89Single7DFPSpiperone7DFP-D2-Spiperone
38.89Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
38.89Single7YITNalfurafine7YIT-κ-Nalfurafine
38.89Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
38.89Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
38.89Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
38.89Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
38.89Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
38.89Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
38.89Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
38.89Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
38.89Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
38.89Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
38.89Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
38.89Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
38.89Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
38.46Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
38.46Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
38.46Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
38.46Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
38.46Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
38.46Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
38.46Consensus5ht2_onOrthosteric Ligand5ht2b_on
38.46Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.46Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
38.46Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
38.46Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
38.46Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
38.10Single3QAKUK-4320973QAK-A2A-UK-432097
37.50Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
37.50Single2Y04Salbutamol2Y04-β1-Salbutamol
37.50Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
37.50Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
37.50Single4QKX35V4QKX-β2-35V
37.50Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
37.50Single5TGZAM65385TGZ-CB1-AM6538
37.50Single6DRXLisuride6DRX-5-HT2B-Lisuride
37.50Single6H7MSalbutamol6H7M-β1-Salbutamol
37.50Single6PS1Timolol6PS1-β2-Timolol
37.50Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
37.50Single6TOTLemborexant6TOT-OX1-Lemborexant
37.50Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
37.50Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
37.50Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
37.50Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
37.50Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
37.50Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
37.50Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
37.50Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
37.50Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
37.50Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
37.50Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
37.50Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
37.50Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
37.50Single7WC7Lisuride7WC7-5-HT2A-Lisuride
37.50Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
37.50Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
37.50Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
37.50Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
37.50Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
37.50Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
37.50Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
37.50Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
37.50Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
37.50Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
37.50Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
37.50Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
37.50Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
37.50Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
37.50Single8T1WCVN4248T1W-GPR6-CVN424
37.50Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
37.50Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
37.50Single8X64Desloratadine8X64-H1-Desloratadine
37.50Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
37.50Single9CHXS-Carazolol9CHX-β2-S-Carazolol
37.50Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
37.50Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
37.50Consensus5ht5_onOrthosteric Ligand5ht5a_on
37.50Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
37.50Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
37.50Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
37.50Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
37.50Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
37.50Consensusblt_onOrthosteric Ligandblt1_on
37.50Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
37.50Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
37.50Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
37.50Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
37.50Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
37.50Consensusleukotriene_onOrthosteric Ligandblt_on
37.50Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
36.84Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
36.84Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
36.84Single5X93K-87945X93-ETB-K-8794
36.84Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
36.84Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
36.84Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
36.84Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.84Single8XVJMacitentan8XVJ-ETA-Macitentan
36.84Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
36.84Consensusendothelin_offOrthosteric Ligandetb_off
36.84Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
36.84Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
35.71Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
35.71Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
35.71Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.71Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
35.71Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
35.71Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
35.71Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
35.71Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
35.71Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
35.29Single2Y03Isoprenaline2Y03-β1-Isoprenaline
35.29Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
35.29Single5C1MBU725C1M-μ-BU72
35.29Single5CGCHTL142425CGC-mGlu5-HTL14242
35.29Single5JQHS-Carazolol5JQH-β2-S-Carazolol
35.29Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
35.29Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
35.29Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
35.29Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
35.29Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
35.29Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
35.29Single6TP6Filorexant6TP6-OX1-Filorexant
35.29Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
35.29Single7C61Ergotamine7C61-5-HT1B-Ergotamine
35.29Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
35.29Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
35.29Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
35.29Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
35.29Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
35.29Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
35.29Single7WC6LSD7WC6-5-HT2A-LSD
35.29Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
35.29Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
35.29Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
35.29Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
35.29Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
35.29Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
35.29Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
35.29Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
35.29Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
35.29Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
35.29Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
35.29Single8ZMFA1L108ZMF-5-HT2C-A1L10
35.29Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
35.29Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29Consensusa3_on_gpOrthosteric Liganda3a_on_gp
35.29Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
35.29Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
35.29Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
35.29Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
35.29Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
35.29Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
35.29Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
35.29Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
35.29Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
35.00Single3NY9ICI118-5513NY9-β2-ICI118-551
35.00Single5ZTYAM102575ZTY-CB2-AM10257
35.00Single6PT3DPI-2876PT3-δ-DPI-287
35.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
35.00Single8X5YAstemizole8X5Y-H1-Astemizole
35.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
35.00Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
35.00Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
33.33Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
33.33Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
33.33Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
33.33Single4DJHJDTic4DJH-κ-JDTic
33.33Single4IARErgotamine4IAR-5-HT1B-Ergotamine
33.33Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
33.33Single4S0VSuvorexant4S0V-OX2-Suvorexant
33.33Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
33.33Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
33.33Single6AKXA4R6AKX-CCR5-A4R
33.33Single6AKYMaraviroc6AKY-CCR5-Maraviroc
33.33Single6B73MP11046B73-κ-MP1104
33.33Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
33.33Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
33.33Single6H7JIsoprenaline6H7J-β1-Isoprenaline
33.33Single6J21Aprepitant6J21-NK1-Aprepitant
33.33Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
33.33Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
33.33Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
33.33Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
33.33Single6TODEMPA6TOD-OX1-EMPA-Na
33.33Single6TPJSuvorexant6TPJ-OX2-Suvorexant
33.33Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
33.33Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
33.33Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
33.33Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
33.33Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
33.33Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
33.33Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
33.33Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
33.33Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
33.33Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
33.33Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
33.33Single8E0GBU728E0G-μ-BU72
33.33Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
33.33Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
33.33Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
33.33Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
33.33Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
33.33Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
33.33Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
33.33Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
33.33Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
33.33Single8XVLZibotentan8XVL-ETA-Zibotentan
33.33Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
33.33Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
33.33Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
33.33Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
33.33Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
33.33Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
33.33Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
33.33Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
33.33Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
33.33Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
33.33Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
33.33Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
33.33Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
33.33Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
33.33Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
33.33Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
33.33Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
33.33Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
33.33Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
33.33Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
33.33Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
31.82Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
31.82Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
31.82Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
31.58Single4LDEBI1671074LDE-β2-BI167107
31.58Single4RWADIPP-NH24RWA-δ-DIPP-NH2
31.58Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
31.58Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
31.58Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
31.58Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
31.58Single7K15MKD0467K15-BLT1-MKD046-Na
31.58Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
31.58Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
31.58Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
31.58Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
31.58Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
31.58Single8JJ8Formoterol8JJ8-β2-Formoterol
31.58Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
31.58Consensusalpha1_offOrthosteric Ligandalpha1a_off
31.58Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
31.58Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
31.58Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
31.58Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
31.58Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
31.58Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
31.58Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
31.25Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
31.25Single4MBSMaraviroc4MBS-CCR5-Maraviroc
31.25Single4ZJCSB-6740424ZJC-OX1-SB-674042
31.25Single6A94Zotepine6A94-5-HT2A-Zotepine
31.25Single6FFIMMPEP6FFI-mGlu5-MMPEP
31.25Single6KUXRS-799486KUX-α2a-RS-79948
31.25Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
31.25Single6PS5S-Propranolol6PS5-β2-S-Propranolol
31.25Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
31.25Single6TP3Nemorexant6TP3-OX1-Nemorexant
31.25Single6TPGEMPA6TPG-OX2-EMPA
31.25Single6TPNHTL66416TPN-OX2-HTL6641
31.25Single6VI4JDTic6VI4-κ-JDTic
31.25Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
31.25Single6ZG9GSK10347026ZG9-M1-GSK1034702
31.25Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
31.25Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
31.25Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.25Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
31.25Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
31.25Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
31.25Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
31.25Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
31.25Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
31.25Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
31.25Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
31.25Single9BJKNaloxone9BJK-μ-Naloxone-NAM
31.25Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
31.25Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
31.25Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
31.25Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
31.25Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
30.77Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
30.77Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
30.77Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
30.77Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
30.77Consensussensory_onOrthosteric Ligandopsins_on
30.43Single6PT2KGCHM076PT2-δ-KGCHM07
30.43Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
30.43Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.43Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
30.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
30.00Single5CGDHTL142425CGD-mGlu5-HTL14242
30.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
30.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
30.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
30.00Single6H7LDobutamine6H7L-β1-Dobutamine
30.00Single6IBLArformoterol6IBL-β1-Arformoterol
30.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
30.00Single7EZCUKA7EZC-A2A-UKA
30.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
30.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
30.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
30.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
30.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
30.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
30.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
30.00Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
30.00Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
30.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
30.00Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
30.00Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
29.41Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
29.41Single2Y01Dobutamine2Y01-β1-Dobutamine
29.41Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
29.41Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
29.41Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
29.41Single5DHHSB-6121115DHH-NOP-SB-612111
29.41Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
29.41Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
29.41Single6FFHFenobam6FFH-mGlu5-Fenobam
29.41Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
29.41Single7BU7BI1671077BU7-β1-BI167107
29.41Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
29.41Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
29.41Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
29.41Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
29.41Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
29.41Single7UL4Alvimopan7UL4-μ-Alvimopan
29.41Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
29.41Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
29.41Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
29.41Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
29.41Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
29.41Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
29.41Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
29.41Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
29.41Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
29.41Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
29.41Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
29.41Single8RLNLUF58348RLN-A2A-LUF5834
29.41Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
29.41Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
29.41Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
29.41Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
29.41Consensusa3_onOrthosteric Liganda3a_on
29.41Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
29.41Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
29.41Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
29.17Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
29.17Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
28.57Single5WF6UK-4320975WF6-A2A-UK-432097
28.57Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
28.57Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
28.57Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
28.57Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
28.57Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
28.57Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
28.57Consensusgi_sensoryOrthosteric Ligandgi_opsins
28.57Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
28.57Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
27.78Single2Y00Dobutamine2Y00-β1-Dobutamine
27.78Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
27.78Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
27.78Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
27.78Single5TVNLSD5TVN-5-HT2B-LSD
27.78Single5WIUNemonapride5WIU-D4-Nemonapride
27.78Single5WIVNemonapride5WIV-D4-Nemonapride-Na
27.78Single5WQCEMPA5WQC-OX2-EMPA
27.78Single5XPRBosentan5XPR-ETB-Bosentan
27.78Single6E67BI1671076E67-β2-BI167107-Gs (fused)
27.78Single6HLPNetupitant6HLP-NK1-Netupitant
27.78Single6LUQHaloperidol6LUQ-D2-Haloperidol
27.78Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
27.78Single7C4SS1P7C4S-S1P3-S1P
27.78Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
27.78Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
27.78Single7SINNPS-21437SIN-CaS-NPS-2143
27.78Single7SINNPS-21437SIN-CaS-NPS-2143
27.78Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
27.78Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
27.78Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
27.78Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
27.78Single8S4DCMF-0198S4D-Apelin-CMF-019
27.78Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
27.78Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
27.78Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
27.78Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
27.78Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
27.78Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
27.78Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
27.78Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
27.78Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
27.78Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
27.78Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
27.27Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
27.27Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
27.27Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
27.27Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
27.27Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
27.27Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
27.27Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
26.67Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
26.67Single3PBLEticlopride3PBL-D3-Eticlopride
26.67Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
26.67Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
26.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
26.67Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
26.67Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
26.67Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
26.67Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
26.67Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
26.67Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
26.67Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
26.67Single8K5BNiacin8K5B-HCA2-Niacin
26.67Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
26.67Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
26.67Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
26.67Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
26.67Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
26.67Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
26.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
26.32Single3P0GBI1671073P0G-β2-BI167107
26.32Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
26.32Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
26.32Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
26.32Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
26.32Single6E59L-7607356E59-NK1-L-760735
26.32Single6J20Aprepitant6J20-NK1-Aprepitant
26.32Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
26.32Single6WGTLSD6WGT-5-HT2A-LSD
26.32Single7B6WCyclazosin7B6W-α1b-Cyclazosin
26.32Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
26.32Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
26.32Single7P2L4YI7P2L-mGlu5-4YI
26.32Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
26.32Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
26.32Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
26.32Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
26.32Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
26.32Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
26.32Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
26.32Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
26.32Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
26.32Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
26.32Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
26.32Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
26.32Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
26.32Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
26.32Consensusa2_onOrthosteric Liganda2b_on
26.32Consensusa2_on_gpOrthosteric Liganda2b_on_gp
26.32Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
26.32Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
26.32Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
26.32Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
26.32Consensustachykinin_offOrthosteric Ligandnk1_off
26.09Single6HLOAprepitant6HLO-NK1-Aprepitant
26.09Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
25.93Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
25.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
25.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
25.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
25.00Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
25.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
25.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
25.00Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
25.00Single5WS3EMPA5WS3-OX2-EMPA
25.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
25.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
25.00Single6MXTSalmeterol6MXT-β2-Salmeterol
25.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
25.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
25.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
25.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
25.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
25.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
25.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
25.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
25.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
25.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
25.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
25.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
25.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
25.00Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
25.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
25.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
25.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
25.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
25.00Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
25.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
25.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
25.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
25.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
25.00Single8JJLOlodaterol8JJL-β2-Olodaterol
25.00Single8JWY2-1188JWY-A2A-2-118
25.00Single8JWZAB9288JWZ-A2A-AB928-Na
25.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
25.00Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
25.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
25.00Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
25.00Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
25.00Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8XYIVUF106618XYI-CXCR3-VUF10661
25.00Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
25.00Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
25.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
25.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
25.00Consensusangiotensin_offOrthosteric Ligandat1_off
25.00Consensusangiotensin_onOrthosteric Ligandat1_on
25.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
25.00Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
25.00Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
25.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
25.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
25.00Consensuslpa_offOrthosteric Ligandlpa1_off
25.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
25.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
25.00Consensusorexin_onOrthosteric Ligandox2_on
25.00Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
25.00Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
25.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
25.00Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
25.00Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
25.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.14Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
24.14Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
24.14Consensusbombesin_onOrthosteric Ligandbb2_on
24.14Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
24.14Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
24.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
24.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
24.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
24.00Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
24.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
24.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
23.81Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
23.81Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
23.81Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
23.81Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.81Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
23.81Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
23.81Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
23.81Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
23.81Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
23.81Consensusprostanoid_offOrthosteric Ligandep_off dp_off
23.81Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
23.81Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
23.81Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
23.53Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
23.53Single6IQLL7458706IQL-D4-L745870
23.53Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
23.53Single6TPKRetosiban6TPK-OT-Retosiban
23.53Single6V9SGTPL114036V9S-OX1-GTPL11403
23.53Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
23.53Single7T32ZM-2413857T32-A2A-ZM-241385
23.53Single7VODCariprazine7VOD-5-HT2A-Cariprazine
23.53Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
23.53Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
23.53Single8IHKAcifran8IHK-HCA3-Acifran
23.53Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
23.53Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
23.53Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
23.53Single8K5CAcipimox8K5C-HCA2-Acipimox
23.53Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
23.53Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
23.53Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
23.53Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
23.53Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
23.53Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
23.53Consensushca_onOrthosteric Ligandhca2_on
23.53Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
23.53Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
23.53Consensusvasop-oxy_offOrthosteric Ligandot_off
23.08Single7WC4Serotonin7WC4-5-HT2A-Serotonin
23.08Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
23.08Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
23.08Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
22.73Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
22.73Single7XN9L-054,5227XN9-SST2-L-054,522
22.73Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
22.73Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
22.73Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
22.73Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
22.73Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
22.73Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
22.73Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
22.73Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single2Y02Carmoterol2Y02-β1-Carmoterol
22.22Single4YAYZD-71554YAY-AT1-ZD-7155
22.22Single5DHGC-355DHG-NOP-C-35
22.22Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
22.22Single6GPSMK08126GPS-CCR2-MK0812
22.22Single6IIVDaltroban6IIV-TP-Daltroban
22.22Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
22.22Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
22.22Single7F83PF-051904577F83-Ghrelin-PF-05190457
22.22Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
22.22Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
22.22Single8CU6LJ-45178CU6-A2A-LJ-4517
22.22Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
22.22Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
22.22Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
22.22Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
22.22Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
22.22Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
22.22Single8K5DGSK2560738K5D-HCA2-GSK256073
22.22Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
22.22Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
22.22Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
22.22Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
22.22Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
22.22Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
22.22Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
22.22Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
22.22Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
22.22Consensushca_on_gpOrthosteric Ligandhca2_on_gp
22.22Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
21.74Single7QA8Peptide7QA8-STE2-Peptide
21.74Single7QA8Peptide7QA8-STE2-Peptide
21.74Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
21.74Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
21.74Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
21.74Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
21.74Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
21.74Consensuslpl_onOrthosteric Ligands1p_on lpa_on
21.74Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
21.74Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.43Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
21.43Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
21.43Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
21.43Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
21.43Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
21.43Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
21.05Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
21.05Single5N2RPSB-365N2R-A2A-PSB-36-Na
21.05Single5N2SPSB365N2S-A1-PSB36
21.05Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
21.05Single6D26Fevipiprant6D26-DP2-Fevipiprant
21.05Single6GPXMK08126GPX-CCR2-MK0812
21.05Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
21.05Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
21.05Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
21.05Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
21.05Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
21.05Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
21.05Single7W41PD1762527W41-BB2-PD176252
21.05Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.05Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
21.05Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
21.05Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
21.05Single8JXSPF-61428JXS-D1-PF-6142
21.05Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
21.05Single8TF5Oleic acid8TF5-GPR6-Oleic acid
21.05Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
21.05Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
21.05Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
21.05Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
21.05Consensusadenosine_offOrthosteric Liganda1_off a2_off
21.05Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
21.05Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
21.05Consensusblt_offOrthosteric Ligandblt1_off
21.05Consensusbombesin_offOrthosteric Ligandbb2_off
21.05Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
21.05Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
21.05Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
21.05Consensusdp_offOrthosteric Liganddp2_off
21.05Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
21.05Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
20.83Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
20.83Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
20.83Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
20.83Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
20.83Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
20.83Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
20.83Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
20.83Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
20.83Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
20.83Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
20.83Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
20.69Single6IGLIRL16206IGL-ETB-IRL1620
20.69Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
20.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
20.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
20.00Single3UZAGTPL92363UZA-A2A-GTPL9236
20.00Single5TZRMK86665TZR-FFA1-MK8666
20.00Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
20.00Single5XR8AM8415XR8-CB1-AM841
20.00Single5XRAAM115425XRA-CB1-AM11542
20.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
20.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
20.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
20.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
20.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
20.00Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
20.00Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
20.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
20.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
20.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
20.00Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
20.00Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
20.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
20.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
20.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
20.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
20.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
20.00Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
20.00Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
20.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
20.00Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
20.00Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
20.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
20.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
20.00Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
20.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
20.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
20.00Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
20.00Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
20.00Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.00Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
20.00Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
20.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
20.00Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
20.00Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
20.00Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
20.00Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
19.23Single6JODAngiotensin II6JOD-AT2-Angiotensin II
19.23Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
19.23Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
19.23Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
19.23Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
19.23Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
19.23Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
19.23Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.23Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
19.23Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
19.23Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
19.23Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
19.23Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
19.23Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
19.23Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
19.23Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
19.23Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
19.23Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
19.23Consensusvasop-oxy_onOrthosteric Ligandv2_on
19.23Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
19.05Single4N4WSANT-14N4W-SMO-SANT-1
19.05Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
19.05Single5X33BIIL2605X33-BLT1-BIIL260
19.05Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
19.05Single6IIURamatroban6IIU-TP-Ramatroban
19.05Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
19.05Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
19.05Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
19.05Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
19.05Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
19.05Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
19.05Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
19.05Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
19.05Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
19.05Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
19.05Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
19.05Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
19.05Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
18.75Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
18.75Single6HLLCP999946HLL-NK1-CP99994
18.75Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
18.75Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
18.75Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
18.75Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
18.75Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
18.75Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
18.75Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
18.75Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single9B9Y7DY9B9Y-CB1-7DY
18.75Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
18.75Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
18.75Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
18.52Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
18.52Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
18.52Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
18.52Single8ZRTET-18ZRT-ETB-ET-1
18.52Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
18.52Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
18.52Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
18.52Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.18Single6K1QIRL25006K1Q-ETB-IRL2500
18.18Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
18.18Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
18.18Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
18.18Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
18.18Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
18.18Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
18.18Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
18.18Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
18.18Consensuschemerin_onOrthosteric Ligandcml1_on
18.18Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
18.18Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
17.86Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
17.86Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
17.86Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
17.65Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
17.65Single5U09Taranabant5U09-CB1-Taranabant
17.65Single6ME9Ramelteon6ME9-MT2-Ramelteon
17.65Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
17.65Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
17.65Single7F8ULintitript7F8U-CCKA-Lintitript
17.65Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
17.65Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.65Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.65Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
17.65Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
17.65Single7XRRLemborexant7XRR-OX2-Lemborexant
17.65Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
17.65Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single8GNGIstradefylline8GNG-A2A-Istradefylline
17.65Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
17.65Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
17.65Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
17.65Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
17.65Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
17.65Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
17.65Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
17.65Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
17.39Single5EE7MK08935EE7-Glucagon-MK0893
17.39Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
17.39Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
17.39Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
17.39Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
17.39Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
17.39Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
17.39Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
17.39Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
17.39Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
17.39Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8QJ2pN1628QJ2-MC4-pN162-Gs
17.39Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
17.39Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
17.39Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
17.39Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
17.24Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
17.24Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
17.24Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
17.24Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
17.24Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
17.24Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
17.24Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
17.24Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
17.24Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
17.24Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
17.24Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
16.67Single5IU7Q274563465IU7-A2A-Q27456346-Na
16.67Single5JTBZM-2413855JTB-A2A-ZM-241385
16.67Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
16.67Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
16.67Single6AQFZM-2413856AQF-A2A-ZM-241385
16.67Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
16.67Single6MH8ZM-2413856MH8-A2A-ZM-241385
16.67Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
16.67Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
16.67Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
16.67Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
16.67Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
16.67Single7AROLUF58337ARO-A2A-LUF5833-Na
16.67Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
16.67Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
16.67Single7F8XNN90567F8X-CCKA-NN9056
16.67Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.67Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
16.67Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
16.67Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
16.67Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
16.67Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
16.67Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
16.67Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
16.67Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
16.67Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
16.67Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
16.67Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
16.67Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8IEBA1LYA8IEB-GPR156-A1LYA
16.67Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
16.67Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
16.67Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
16.67Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.67Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
16.67Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
16.67Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
16.67Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
16.67Single8WKYPG-9348WKY-MC4-PG-934
16.67Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
16.67Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
16.67Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
16.67Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
16.67Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
16.67Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
16.67Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
16.67Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
16.67Consensusa2_offOrthosteric Liganda2a_off
16.67Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
16.67Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
16.67Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
16.67Consensusbradykinin_onOrthosteric Ligandbk2_on
16.67Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
16.67Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
16.67Consensusendothelin_onOrthosteric Ligandetb_on eta_on
16.67Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
16.13Single5GLHEndothelin-15GLH-ETB-Endothelin-1
16.13Single6IGKEndothelin-36IGK-ETB-Endothelin-3
16.13Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
16.13Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
16.13Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
16.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
16.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
16.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
16.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
16.00Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
16.00Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
16.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
16.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
16.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
15.79Single3EMLZM-2413853EML-A2A-ZM-241385
15.79Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
15.79Single5IU8Q274563475IU8-A2A-Q27456347-Na
15.79Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
15.79Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
15.79Single5UENDU1725UEN-A1-DU172
15.79Single5UIGCmpd-15UIG-A2A-Cmpd-1
15.79Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
15.79Single6D27CAY104716D27-DP2-CAY10471
15.79Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
15.79Single6S0LZM-2413856S0L-A2A-ZM-241385
15.79Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
15.79Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
15.79Single7PYRPSB-21157PYR-A2A-PSB-2115
15.79Single7V3ZCP559407V3Z-CB1-CP55940
15.79Single7YXAONO-54306087YXA-S1P5-ONO-5430608
15.79Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
15.79Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
15.79Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
15.79Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
15.79Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
15.79Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
15.79Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
15.79Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
15.79Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
15.79Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
15.79Single9B9ZA1AKO9B9Z-CB1-A1AKO
15.79Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
15.79Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
15.79Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
15.79Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
15.79Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
15.62Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
15.62Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
15.62Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
15.62Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
15.62Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
15.38Single5MZPCaffeine5MZP-A2A-Caffeine-Na
15.38Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
15.38Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
15.38Single6W25SHU91196W25-MC4-SHU9119-Ca
15.38Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
15.38Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.38Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
15.38Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
15.38Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
15.38Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
15.38Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
15.15Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
15.15Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
15.15Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
15.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
15.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
15.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
15.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
15.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
15.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
15.00Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
15.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
15.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
15.00Single6S0QZM-2413856S0Q-A2A-ZM-241385
15.00Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
15.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
15.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
15.00Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
15.00Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
15.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
15.00Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
15.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
15.00Single8QOTNanobody-E8QOT-μ-Nanobody-E
15.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
15.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
15.00Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
15.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
15.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
15.00Consensusep_offOrthosteric Ligandep4_off
15.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
15.00Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
15.00Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
14.81Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
14.81Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
14.81Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
14.81Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
14.81Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
14.81Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
14.81Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
14.81Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
14.81Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
14.81Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
14.81Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
14.81Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
14.71Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
14.71Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
14.71Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
14.29Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
14.29Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
14.29Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
14.29Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
14.29Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7FEECP559407FEE-CB1-CP55940-ZCZ011
14.29Single7PX4PSB-21137PX4-A2A-PSB-2113
14.29Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
14.29Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
14.29Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
14.29Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
14.29Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
14.29Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
14.29Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
14.29Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
14.29Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
14.29Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
14.29Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
14.29Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
14.29Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
14.29Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
14.29Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
14.29Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8PWNTheophylline8PWN-A2A-Theophylline
14.29Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
14.29Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
14.29Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
14.29Single9BJKNAM9BJK-μ-Naloxone-NAM
14.29Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
14.29Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.29Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
14.29Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.79Single6FJ3PTH6FJ3-PTH1-PTH
13.79Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
13.79Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
13.79Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
13.79Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
13.79Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
13.79Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
13.79Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
13.79Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
13.79Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
13.64Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
13.64Single6KQICP559406KQI-CB1-CP55940-Org27569
13.64Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
13.64Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
13.64Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
13.64Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
13.64Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
13.64Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
13.64Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
13.64Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
13.64Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
13.64Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
13.64Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
13.33Single3OE8IT1t3OE8-CXCR4-IT1t
13.33Single3RFMCaffeine3RFM-A2A-Caffeine
13.33Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
13.33Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
13.33Single6TQ9SB-4081246TQ9-OX1-SB-408124
13.33Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
13.33Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
13.33Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
13.33Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
13.33Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
13.33Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
13.33Single8A2OTheophylline8A2O-A2A-Theophylline-Na
13.33Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
13.33Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
13.33Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
13.33Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
13.16Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
13.04Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
13.04Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
13.04Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
13.04Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
13.04Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
13.04Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
13.04Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
13.04Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
13.04Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
13.04Consensuscck_onOrthosteric Ligandccka_on cckb_on
13.04Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
12.90Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
12.90Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
12.90Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
12.90Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
12.90Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
12.90Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
12.90Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
12.90Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
12.90Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
12.90Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
12.90Single8IY6Endothelin-18IY6-ETB-Endothelin-1
12.90Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
12.82Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
12.50Single3OE6IT1t3OE6-CXCR4-IT1t
12.50Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
12.50Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
12.50Single6ME5Agomelatine6ME5-MT1-Agomelatine
12.50Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
12.50Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
12.50Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
12.50Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
12.50Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
12.50Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
12.50Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
12.50Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.50Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
12.50Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
12.50Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
12.50Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
12.50Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
12.50Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
12.50Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.50Consensuskisspeptin_onOrthosteric Ligandkiss1_on
12.12Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
12.12Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
12.12Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
12.12Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
12.12Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
12.12Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
12.00Single4XT1Fractalkine4XT1-US28-Fractalkine
12.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
12.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
12.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
12.00Single8KIGSHU91198KIG-MC3-SHU9119-Ca
12.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
12.00Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.00Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.00Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
12.00Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
12.00Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
12.00Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
12.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
11.76Single3OE9IT1t3OE9-CXCR4-IT1t
11.76Single5L7IVismodegib5L7I-SMO-Vismodegib
11.76Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
11.76Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
11.76Single6TP4ACT-4622066TP4-OX1-ACT-462206
11.76Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
11.76Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
11.76Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
11.76Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
11.76Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
11.76Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
11.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.76Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
11.76Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
11.76Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
11.54Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
11.54Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
11.54Single7SHEPI; PE7SHE-GPR158-PI; PE
11.54Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
11.54Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
11.54Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
11.54Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
11.54Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
11.54Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
11.54Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
11.54Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
11.54Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
11.54Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
11.54Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
11.54Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
11.43Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
11.11Single3ODUIT1t3ODU-CXCR4-IT1t
11.11Single3OE0CVX153OE0-CXCR4-CVX15
11.11Single3PWHZM-2413853PWH-A2A-ZM-241385
11.11Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
11.11Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
11.11Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
11.11Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
11.11Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
11.11Single5ZKQABT-4915ZKQ-PAF-ABT-491
11.11Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
11.11Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
11.11Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.11Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
11.11Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
11.11Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.11Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
11.11Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
11.11Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
11.11Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
11.11Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
11.11Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
11.11Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
11.11Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
11.11Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
11.11Single9BA0A1AKN9BA0-CB1-A1AKN
11.11Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
11.11Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
11.11Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
11.11Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.11Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
11.11Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.11Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.11Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
10.81Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
10.81Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
10.71Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
10.71Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.71Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
10.71Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
10.71Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
10.71Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
10.71Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
10.71Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
10.71Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
10.71Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
10.71Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
10.53Single3REYXAC3REY-A2A-XAC
10.53Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
10.53Single5IUBQ274563445IUB-A2A-Q27456344-Na
10.53Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
10.53Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
10.53Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
10.53Single5UVIZM-2413855UVI-A2A-ZM-241385
10.53Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
10.53Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
10.53Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
10.53Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
10.53Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
10.53Single8IYXYL-3658IYX-GPR34-YL-365
10.53Single8K2WAMG4878K2W-CXCR3-AMG487
10.53Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.53Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
10.53Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
10.53Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
10.53Consensusgrh_offOrthosteric Ligandgnrh1_off
10.53Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
10.34Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
10.34Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
10.34Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
10.34Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
10.34Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
10.34Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
10.34Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
10.34Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
10.34Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
10.34Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
10.34Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
10.34Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
10.00Single4XT3Fractalkine4XT3-US28-Fractalkine
10.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
10.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
10.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
10.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
10.00Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
10.00Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
10.00Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
10.00Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
10.00Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
10.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
10.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
10.00Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
10.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
10.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
10.00Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
10.00Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
10.00Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
10.00Single9IYAONO-97105319IYA-GPR55-ONO-9710531
10.00Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
10.00Consensuscck_offOrthosteric Ligandccka_off
10.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
10.00Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
10.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
10.00Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
9.68Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
9.68Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
9.68Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
9.68Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
9.52Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
9.52Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
9.52Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
9.52Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
9.52Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
9.52Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
9.52Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
9.52Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
9.52Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
9.52Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
9.52Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
9.38Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
9.38Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
9.38Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
9.38Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
9.30Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
9.09Single7R0CAVP7R0C-V2-AVP-Arrestin2
9.09Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
9.09Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
9.09Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
9.09Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
9.09Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
9.09Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
9.09Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
9.09Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
9.09Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
9.09Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
9.09Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
9.09Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
9.09Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
9.09Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
9.09Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
9.09Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
9.09Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
9.09Consensuslpa_onOrthosteric Ligandlpa1_on
9.09Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
9.09Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
9.09Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
9.09Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
9.09Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
9.09Consensusrelaxin_onOrthosteric Ligandrxfp4_on
9.09Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
8.70Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
8.70Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
8.70Single7SHEPI; PE7SHE-GPR158-PI; PE
8.70Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
8.70Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.70Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
8.70Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
8.70Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
8.70Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
8.70Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
8.70Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.70Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.57Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
8.57Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
8.57Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
8.33Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
8.33Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
8.33Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
8.33Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
8.33Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
8.33Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
8.33Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
8.33Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
8.33Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
8.33Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
8.33Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
8.33Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
8.33Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
8.33Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
8.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
8.00Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
8.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
8.00Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
8.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
8.00Single8IEIA1LYA8IEI-GPR156-A1LYA
8.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
8.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.00Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
8.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
8.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
8.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
8.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
7.69Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
7.69Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
7.69Single8IEIA1LYA8IEI-GPR156-A1LYA
7.69Single8IEPA1LYA8IEP-GPR156-A1LYA
7.69Single8IEPA1LYA8IEP-GPR156-A1LYA
7.69Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
7.69Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
7.69Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensussomatostatin_offOrthosteric Ligandsst2_off
7.41Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
7.41Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
7.41Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
7.41Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
7.41Single7SK5CXCL127SK5-ACKR3-CXCL12
7.41Single7XNACYN1548067XNA-SST2-CYN154806
7.41Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single8IEBA1LYA8IEB-GPR156-A1LYA
7.41Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.41Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
7.41Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
7.41Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
7.14Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
7.14Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
7.14Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
7.14Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
7.14Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
6.90Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
6.90Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
6.90Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
6.90Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
6.90Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
6.67Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
6.67Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
6.67Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
6.67Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
6.67Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
6.67Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.67Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
6.67Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
6.67Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
6.45Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
6.45Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
6.45Single7SK3CXCL127SK3-ACKR3-CXCL12
6.45Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
6.25Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.25Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
6.25Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
6.25Single8IKGQ2B8IKG-CB1-Q2B-Gi1/β1/γ1
6.06Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
5.88Single6OBAGTPL110746OBA-β2-S-Alprenolol-GTPL11074
5.88Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
5.88Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
5.88Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.88Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
5.88Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
5.71Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
5.71Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
5.56Single6LI0C176LI0-GPR52-C17
5.56Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
5.56Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
5.56Single8IKHQ2L8IKH-CB1-Q2L-Gi1/β1/γ1
5.56Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.56Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
5.56Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.56Single8K9LVV98K9L-μ-Damgo-VV9-Gi3/β1/γ1
5.41Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
5.26Single4K5YCP-3763954K5Y-CRF1-CP-376395
5.26Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
5.26Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
5.26Single7F8YDevazepide7F8Y-CCKA-Devazepide
5.26Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
5.26Single7WV9ZCZ0117WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
5.26Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.26Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
5.26Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
5.00Single5O9HNDT95137275O9H-C5a1-NDT9513727
5.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
5.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
5.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.00Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
5.00Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
5.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
5.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
4.76Single4QIMANTA XV4QIM-SMO-ANTA XV
4.76Single4Z9GCP-3763954Z9G-CRF1-CP-376395
4.76Single6C1RAvacopan; Na6C1R-C5a1-PMX53-Avacopan; Na
4.76Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
4.76Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
4.76Single8GTIBMK-C2058GTI-CRF1-BMK-C205
4.76Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
4.76Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
4.76Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
4.55Single4JKVTaladegib4JKV-SMO-Taladegib
4.55Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
4.55Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
4.55Single8GTGBMK-I1528GTG-CRF1-BMK-I152
4.55Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.55Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single5V56TC1145V56-SMO-TC114
4.35Single5V57TC1145V57-SMO-TC114
4.35Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
4.35Single6OS1TRV0266OS1-AT1-TRV026
4.35Single7F1TMIP-1a7F1T-CCR5-MIP-1a
4.35Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
4.35Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.35Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
4.35Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
4.17Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
4.17Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
4.17Single4PY02MeSATP4PY0-P2Y12-2MeSATP
4.17Single6OS2TRV0266OS2-AT1-TRV026
4.17Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
4.17Single8GTMBMK-C2038GTM-CRF1-BMK-C203
4.17Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.17Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
4.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
4.00Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
4.00Single8XVUCXCL28XVU-CXCR2-CXCL2
4.00Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
3.85Single6KNMJN241-96KNM-Apelin-JN241-9
3.85Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
3.85Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
3.85Single8XQJJN2418XQJ-Apelin-JN241
3.85Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
3.85Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
3.70Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
3.70Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
3.70Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
3.70Single8XWNCXCL88XWN-CXCR2-CXCL8
3.57Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
3.57Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
3.57Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
3.45Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
3.45Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
3.45Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
3.45Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
3.45Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
3.23Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
3.12Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2

Consensus Members
Id Members
8JXX 8JXX-H4-Clobenpropit-Gi1/β1/γ2
8JXV 8JXV-H4-Clozapine-Gi1/β1/γ2
8YUU 8YUU-H3-Histamine-Gi1/β1/γ1
8HN8 8HN8-H4-Histamine-Gi1/β1/γ2
8HOC 8HOC-H4-Imetit-Gi1/β1/γ2
8JXW 8JXW-H4-VUF6884-Gi1/β1/γ2
Net Summary
Imin 2.33333
Number of Linked Nodes 892
Number of Links 1116
Number of Hubs 189
Number of Links mediated by Hubs 696
Number of Communities 27
Number of Nodes involved in Communities 262
Number of Links involved in Communities 390
Path Summary
Number Of Nodes in MetaPath 96
Number Of Links MetaPath 95
Number of Shortest Paths 11701507
Length Of Smallest Path 3
Average Path Length 48.8917
Length of Longest Path 79
Minimum Path Strength 0.365833
Average Path Strength 4.43955
Maximum Path Strength 21.2908
Minimum Path Correlation 0.705
Average Path Correlation 0.993246
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.38889
Average % Of Corr. Nodes 21.2738
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 60.0702
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gi_aminegi_5ht
gi_muscarinic
gi_adrenergic
gi_dopamine
gi_histamine



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