psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S19	R:R:T22	3.2	No	No	0	1	5
2	R:R:V21	R:R:Y80	3.79	No	Yes	0	6	6
3	R:R:M81	R:R:V21	6.09	No	No	0	4	6
4	R:R:I23	R:R:P24	3.39	No	Yes	0	6	7
5	R:R:I23	R:R:M27	4.37	No	No	0	6	8
6	R:R:P24	R:R:T76	3.5	Yes	No	4	7	8
7	R:R:P24	R:R:Y80	4.17	Yes	Yes	4	7	6
8	L:L:?1	R:R:P24	4.57	Yes	Yes	4	0	7
9	L:L:?1	R:R:M27	7.86	Yes	No	0	0	8
10	R:R:F28	R:R:V32	6.55	No	No	3	6	7
11	R:R:F28	R:R:T69	3.89	No	No	3	6	8
12	R:R:F28	R:R:S73	7.93	No	No	3	6	8
13	R:R:F30	R:R:W327	9.02	No	No	0	5	7
14	R:R:G31	R:R:I323	5.29	No	No	0	8	8
15	R:R:G34	R:R:P326	4.06	No	No	0	9	9
16	R:R:G34	R:R:W327	4.22	No	No	0	9	7
17	R:R:L66	R:R:N35	12.36	Yes	No	0	8	9
18	R:R:N35	R:R:P326	8.15	No	No	0	9	9
19	R:R:I330	R:R:V37	3.07	No	No	0	8	6
20	R:R:A38	R:R:L62	4.73	No	No	0	9	8
21	R:R:A38	R:R:I330	3.25	No	No	0	9	8
22	R:R:I39	R:R:L62	4.28	No	No	0	8	8
23	R:R:L42	R:R:Y55	7.03	No	No	0	8	8
24	R:R:L42	R:R:Y329	5.86	No	No	0	8	9
25	R:R:K47	R:R:T52	3	No	No	0	6	7
26	R:R:K47	R:R:Y55	9.55	No	No	0	6	8
27	R:R:E48	R:R:K50	4.05	No	No	0	7	7
28	R:R:E48	R:R:E51	21.57	No	Yes	0	7	7
29	R:R:E267	R:R:K50	8.1	No	No	0	8	7
30	R:R:E51	R:R:Y55	14.59	Yes	No	0	7	8
31	R:R:A266	R:R:E51	3.02	No	Yes	0	7	7
32	R:R:E51	R:R:M270	4.06	Yes	No	0	7	9
33	R:R:E116	R:R:T53	8.47	Yes	No	0	9	6
34	R:R:T53	R:R:V131	3.17	No	No	0	6	7
35	R:R:A136	R:R:T53	3.36	Yes	No	0	8	6
36	R:R:F54	R:R:V58	3.93	Yes	Yes	1	8	8
37	R:R:F54	R:R:M113	4.98	Yes	No	1	8	9
38	R:R:E116	R:R:F54	3.5	Yes	Yes	1	9	8
39	R:R:F54	R:R:R117	4.28	Yes	Yes	1	8	9
40	R:R:F54	R:R:M270	11.2	Yes	No	1	8	9
41	R:R:F54	R:R:L273	3.65	Yes	No	0	8	8
42	R:R:F54	R:R:L274	4.87	Yes	Yes	1	8	8
43	R:R:K133	R:R:T56	10.51	No	No	0	5	6
44	R:R:A136	R:R:T56	3.36	Yes	No	0	8	6
45	R:R:L57	R:R:M113	7.07	No	No	0	8	9
46	R:R:A136	R:R:L57	3.15	Yes	No	0	8	8
47	R:R:L140	R:R:L57	4.15	No	No	0	8	8
48	R:R:M113	R:R:V58	3.04	No	Yes	1	9	8
49	R:R:V58	R:R:Y329	5.05	Yes	No	0	8	9
50	R:R:D65	R:R:L61	8.14	Yes	No	0	9	9
51	R:R:I109	R:R:L61	9.99	No	No	0	8	9
52	R:R:S105	R:R:T64	3.2	No	No	0	8	9
53	R:R:I109	R:R:T64	3.04	No	No	0	8	9
54	R:R:T64	R:R:Y144	8.74	No	No	0	9	8
55	R:R:D65	R:R:R106	7.15	Yes	No	3	9	9
56	R:R:D65	R:R:P322	4.83	Yes	Yes	3	9	9
57	R:R:D325	R:R:D65	7.98	No	Yes	0	9	9
58	R:R:L66	R:R:L70	5.54	Yes	No	3	8	5
59	R:R:F102	R:R:G68	10.54	Yes	No	0	7	8
60	R:R:S73	R:R:T69	4.8	No	No	3	8	8
61	R:R:P322	R:R:T69	3.5	Yes	No	3	9	8
62	R:R:L71	R:R:Y94	4.69	No	No	0	6	5
63	R:R:F102	R:R:L71	6.09	Yes	No	0	7	6
64	R:R:I98	R:R:V72	3.07	No	No	0	5	7
65	L:L:?1	R:R:V72	3.11	Yes	No	0	0	7
66	R:R:S95	R:R:V75	3.23	No	No	0	6	7
67	R:R:T76	R:R:Y80	3.75	No	Yes	4	8	6
68	L:L:?1	R:R:T76	14.35	Yes	No	4	0	8
69	R:R:I77	R:R:M81	4.37	No	No	0	6	4
70	R:R:P86	R:R:T79	6.99	Yes	No	0	4	7
71	R:R:R316	R:R:Y80	3.09	No	Yes	4	7	6
72	L:L:?1	R:R:Y80	11.41	Yes	Yes	4	0	6
73	R:R:K82	R:R:Q84	9.49	No	No	0	5	4
74	R:R:P86	R:R:W85	5.4	Yes	Yes	5	4	6
75	R:R:L91	R:R:W85	11.39	Yes	Yes	5	6	6
76	R:R:S95	R:R:W85	6.18	No	Yes	5	6	6
77	R:R:L163	R:R:W85	11.39	No	Yes	0	4	6
78	R:R:C170	R:R:W85	3.92	No	Yes	0	9	6
79	R:R:L91	R:R:P86	3.28	Yes	Yes	5	6	4
80	R:R:G87	R:R:L91	3.42	No	Yes	0	5	6
81	R:R:P90	R:R:Q89	3.16	No	No	0	2	2
82	R:R:E93	R:R:Q89	7.65	No	No	0	6	2
83	R:R:L91	R:R:S95	3	Yes	No	5	6	6
84	R:R:C170	R:R:C92	7.28	No	No	0	9	9
85	R:R:E93	R:R:N155	6.57	No	No	0	6	5
86	R:R:I98	R:R:Y94	10.88	No	No	0	5	5
87	R:R:S161	R:R:T96	9.59	No	No	0	5	7
88	R:R:C170	R:R:T96	3.38	No	No	0	9	7
89	R:R:I315	R:R:L99	4.28	No	No	0	6	8
90	R:R:C151	R:R:L100	3.17	No	No	0	8	7
91	R:R:L100	R:R:Y188	7.03	No	Yes	0	7	7
92	R:R:F101	R:R:F102	12.86	Yes	Yes	0	7	7
93	R:R:F101	R:R:S105	7.93	Yes	No	0	7	8
94	R:R:F101	R:R:Y144	5.16	Yes	No	0	7	8
95	R:R:F101	R:R:V148	3.93	Yes	No	0	7	4
96	R:R:F102	R:R:R106	4.28	Yes	No	0	7	9
97	R:R:L104	R:R:N147	6.87	No	No	0	8	8
98	R:R:L104	R:R:Y188	8.21	No	Yes	0	8	7
99	R:R:N147	R:R:S105	5.96	No	No	0	8	8
100	R:R:P322	R:R:R106	12.97	Yes	No	3	9	9
101	R:R:L107	R:R:S192	3	No	No	0	8	7
102	R:R:L107	R:R:S285	4.5	No	No	0	8	8
103	R:R:S108	R:R:V143	4.85	No	No	0	7	7
104	R:R:L195	R:R:S108	3	Yes	No	0	8	7
105	R:R:I110	R:R:T199	4.56	Yes	Yes	1	8	8
106	R:R:I110	R:R:T277	3.04	Yes	No	0	8	8
107	R:R:I110	R:R:S278	3.1	Yes	Yes	1	8	8
108	R:R:I110	R:R:V281	9.22	Yes	No	0	8	8
109	R:R:C111	R:R:L195	3.17	No	Yes	0	7	8
110	R:R:C111	R:R:T199	3.38	No	Yes	0	7	8
111	R:R:S114	R:R:T199	6.4	Yes	Yes	1	9	8
112	R:R:C202	R:R:S114	3.44	No	Yes	0	7	9
113	R:R:N203	R:R:S114	5.96	No	Yes	1	9	9
114	R:R:L274	R:R:S114	3	Yes	Yes	1	8	9
115	R:R:E116	R:R:R117	4.65	Yes	Yes	1	9	9
116	R:R:E116	R:R:Y127	7.86	Yes	No	0	9	8
117	R:R:A120	R:R:R117	4.15	No	Yes	0	9	9
118	R:R:I121	R:R:R117	6.26	Yes	Yes	0	9	9
119	R:R:E267	R:R:R117	11.63	No	Yes	0	8	9
120	R:R:M270	R:R:R117	4.96	No	Yes	1	9	9
121	R:R:R117	R:R:V271	3.92	Yes	No	0	9	7
122	R:R:L274	R:R:R117	3.64	Yes	Yes	1	8	9
123	R:R:L119	R:R:Y118	3.52	No	Yes	0	6	8
124	R:R:N122	R:R:Y118	12.79	Yes	Yes	6	7	8
125	R:R:H123	R:R:Y118	6.53	No	Yes	6	7	8
126	R:R:L205	R:R:Y118	8.21	No	Yes	0	5	8
127	R:R:F126	R:R:L119	3.65	No	No	0	5	6
128	R:R:A120	R:R:Y127	9.34	No	No	0	9	8
129	R:R:I121	R:R:N122	4.25	Yes	Yes	0	9	7
130	R:R:I121	R:R:V206	4.61	Yes	No	0	9	9
131	R:R:I121	R:R:L210	5.71	Yes	No	0	9	9
132	R:R:H123	R:R:N122	3.83	No	Yes	6	7	7
133	R:R:A209	R:R:N122	4.69	No	Yes	0	7	7
134	R:R:H129	R:R:Y125	29.4	No	No	0	5	7
135	R:R:F126	R:R:Y130	12.38	No	No	0	5	5
136	R:R:V131	R:R:Y127	8.83	No	No	0	7	8
137	R:R:H129	R:R:S128	5.58	No	No	0	5	6
138	R:R:H129	R:R:Y130	3.27	No	No	0	5	5
139	R:R:L135	R:R:V131	4.47	No	No	0	5	7
140	R:R:D132	R:R:R134	9.53	No	No	0	8	5
141	R:R:F150	R:R:Y184	8.25	No	Yes	0	7	8
142	R:R:F150	R:R:M187	3.73	No	No	0	7	5
143	R:R:F150	R:R:Y188	4.13	No	Yes	0	7	7
144	R:R:L153	R:R:L158	6.92	No	No	7	8	5
145	R:R:L153	R:R:Y184	7.03	No	Yes	7	8	8
146	R:R:G159	R:R:P154	4.06	No	No	0	7	9
147	R:R:P154	R:R:Y184	12.52	No	Yes	0	9	8
148	R:R:L158	R:R:Y184	7.03	No	Yes	7	5	8
149	R:R:G159	R:R:H181	7.94	No	Yes	0	7	5
150	R:R:D173	R:R:S160	5.89	Yes	No	0	5	3
151	R:R:H181	R:R:S160	9.76	Yes	No	0	5	3
152	R:R:Q164	R:R:R162	17.52	No	No	2	7	4
153	R:R:D173	R:R:R162	16.68	Yes	No	2	5	4
154	R:R:R162	R:R:T175	6.47	No	No	2	4	4
155	R:R:D167	R:R:L163	6.79	No	No	0	5	4
156	R:R:Q164	R:R:W169	10.95	No	Yes	2	7	5
157	R:R:Q164	R:R:W174	12.05	No	Yes	2	7	5
158	R:R:P166	R:R:Y165	13.91	Yes	No	0	6	3
159	R:R:L302	R:R:Y165	12.89	No	No	0	1	3
160	R:R:P166	R:R:T168	8.74	Yes	No	0	6	6
161	R:R:P166	R:R:V306	3.53	Yes	No	0	6	3
162	R:R:F171	R:R:W169	11.02	Yes	Yes	2	6	5
163	R:R:W169	R:R:W174	3.75	Yes	Yes	2	5	5
164	R:R:L312	R:R:W169	7.97	No	Yes	0	6	5
165	R:R:I315	R:R:W169	11.74	No	Yes	0	6	5
166	R:R:F171	R:R:I172	7.54	Yes	No	0	6	7
167	R:R:F171	R:R:W174	9.02	Yes	Yes	2	6	5
168	R:R:F171	R:R:L288	6.09	Yes	No	0	6	7
169	R:R:D173	R:R:T175	4.34	Yes	No	2	5	4
170	R:R:D173	R:R:T176	11.56	Yes	No	2	5	4
171	R:R:T175	R:R:W174	4.85	No	Yes	2	4	5
172	R:R:V292	R:R:W174	3.68	No	Yes	0	7	5
173	R:R:N295	R:R:W174	25.99	No	Yes	2	6	5
174	R:R:D311	R:R:W174	12.28	Yes	Yes	2	6	5
175	R:R:T176	R:R:V178	3.17	No	No	2	4	3
176	R:R:H181	R:R:T176	5.48	Yes	No	2	5	4
177	R:R:Q177	R:R:Q299	7.68	No	No	0	4	2
178	R:R:H181	R:R:V178	8.3	Yes	No	2	5	3
179	R:R:A182	R:R:Q296	3.03	No	No	0	5	6
180	R:R:Q296	R:R:S185	7.22	No	No	0	6	7
181	R:R:Q296	R:R:Y186	5.64	No	No	0	6	5
182	R:R:L297	R:R:Y186	5.86	No	No	0	4	5
183	R:R:S192	R:R:Y188	6.36	No	Yes	0	7	7
184	R:R:A189	R:R:F293	8.32	No	No	0	7	6
185	R:R:F191	R:R:L195	9.74	No	Yes	0	6	8
186	R:R:S192	R:R:V289	4.85	No	No	0	7	7
187	R:R:I196	R:R:L282	7.14	No	No	0	7	6
188	R:R:N203	R:R:T199	4.39	No	Yes	1	9	8
189	R:R:S278	R:R:T199	3.2	Yes	Yes	1	8	8
190	R:R:L282	R:R:T199	5.9	No	Yes	0	6	8
191	R:R:N203	R:R:S278	8.94	No	Yes	1	9	8
192	R:R:L210	R:R:V271	4.47	No	No	0	9	7
193	R:R:I263	R:R:M213	4.37	No	No	0	4	7
194	R:R:F218	R:R:H214	4.53	No	No	0	3	5
195	R:R:G265	R:R:I268	5.29	No	No	0	5	6
196	R:R:I275	R:R:V271	3.07	No	No	0	7	7
197	R:R:L273	R:R:Y329	8.21	No	No	0	8	9
198	R:R:L274	R:R:S278	3	Yes	Yes	1	8	8
199	R:R:N321	R:R:V281	5.91	Yes	No	0	9	8
200	R:R:C284	R:R:I317	3.27	No	No	0	9	8
201	R:R:C284	R:R:N321	9.45	No	Yes	0	9	9
202	R:R:I286	R:R:P287	3.39	No	No	0	7	9
203	R:R:R291	R:R:V294	7.85	Yes	No	0	6	5
204	R:R:P310	R:R:R291	10.09	No	Yes	0	4	6
205	R:R:D311	R:R:R291	5.96	Yes	Yes	0	6	6
206	R:R:V294	R:R:Y298	5.05	No	No	0	5	4
207	R:R:P300	R:R:V294	5.3	No	No	0	1	5
208	R:R:N295	R:R:P300	4.89	No	No	0	6	1
209	R:R:D311	R:R:N295	9.42	Yes	No	2	6	6
210	R:R:L297	R:R:Y298	4.69	No	No	0	4	4
211	R:R:E303	R:R:E305	5.07	No	No	8	3	1
212	R:R:E303	R:R:K308	8.1	No	No	8	3	4
213	R:R:E305	R:R:K308	8.1	No	No	8	1	4
214	R:R:N309	R:R:P310	6.52	No	No	0	2	4
215	R:R:D311	R:R:N309	5.39	Yes	No	0	6	2
216	R:R:L312	R:R:N309	13.73	No	No	0	6	2
217	L:L:?1	R:R:R316	33.78	Yes	No	4	0	7
218	L:L:?1	R:R:I317	14.88	Yes	No	0	0	8
219	L:L:?1	R:R:S319	8.35	Yes	No	0	0	8
220	R:R:L324	R:R:V320	4.47	No	No	0	7	5
221	L:L:?1	R:R:V320	5.18	Yes	No	0	0	5
222	R:R:N321	R:R:P322	4.89	Yes	Yes	0	9	9
223	R:R:D325	R:R:N321	12.12	No	Yes	0	9	9
224	R:R:R333	R:R:T335	7.76	No	No	0	9	7
225	R:R:R333	R:R:V336	6.54	No	No	0	9	7
226	R:R:L66	R:R:V32	2.98	Yes	No	3	8	7
227	R:R:L70	R:R:V32	2.98	No	No	3	5	7
228	R:R:L62	R:R:V58	2.98	No	Yes	0	8	8
229	R:R:L67	R:R:V63	2.98	No	No	0	7	5
230	R:R:L119	R:R:V115	2.98	No	No	0	6	7
231	L:L:?1	R:R:I283	2.98	Yes	No	0	0	7
232	R:R:N321	R:R:V280	2.96	Yes	No	0	9	6
233	R:R:L100	R:R:T96	2.95	No	No	0	7	7
234	R:R:L135	R:R:T139	2.95	No	No	0	5	7
235	R:R:I263	R:R:I268	2.94	No	No	0	4	6
236	R:R:I268	R:R:I272	2.94	No	No	0	6	7
237	R:R:I323	R:R:M27	2.92	No	No	0	8	8
238	R:R:I272	R:R:L332	2.85	No	No	0	7	8
239	R:R:I275	R:R:L279	2.85	No	No	0	7	6
240	R:R:I328	R:R:L332	2.85	No	No	0	8	8
241	R:R:C151	R:R:F97	2.79	No	No	0	8	7
242	R:R:A209	R:R:R212	2.77	No	No	0	7	4
243	R:R:L273	R:R:L332	2.77	No	No	0	8	8
244	R:R:D132	R:R:L135	2.71	No	No	0	8	5
245	R:R:F293	R:R:S193	2.64	No	No	0	6	6
246	R:R:F30	R:R:V26	2.62	No	No	0	5	5
247	R:R:R333	R:R:V41	2.62	No	Yes	0	9	7
248	R:R:F293	R:R:V289	2.62	No	No	0	6	7
249	R:R:R291	R:R:V290	2.62	Yes	No	0	6	7
250	R:R:S103	R:R:Y188	2.54	No	Yes	0	7	7
251	R:R:V33	R:R:W327	2.45	No	No	0	5	7
252	R:R:F102	R:R:L67	2.44	Yes	No	0	7	7
253	R:R:G87	R:R:G88	2.11	No	No	0	5	5
254	R:R:G88	R:R:P90	2.03	No	No	0	5	2
255	R:R:C207	R:R:G208	1.96	No	No	0	7	3
256	R:R:A136	R:R:G137	1.95	Yes	No	0	8	5
257	R:R:A264	R:R:G265	1.95	No	No	0	6	5
258	R:R:A78	R:R:P86	1.87	No	Yes	0	6	4
259	R:R:A314	R:R:P287	1.87	No	No	0	7	9
260	R:R:G190	R:R:S193	1.86	No	No	0	5	6
261	R:R:A198	R:R:C111	1.81	No	No	0	6	7
262	R:R:P20	R:R:S19	1.78	No	No	0	5	1
263	R:R:P74	R:R:S73	1.78	No	No	0	9	8
264	R:R:P20	R:R:V21	1.77	No	No	0	5	6
265	R:R:C59	R:R:V63	1.71	No	No	0	6	5
266	R:R:G60	R:R:L140	1.71	No	No	0	8	8
267	R:R:G208	R:R:L211	1.71	No	No	0	3	6
268	R:R:A180	R:R:V178	1.7	No	No	0	3	3
269	R:R:A112	R:R:T139	1.68	No	No	0	8	7
270	R:R:K82	R:R:P86	1.67	No	Yes	0	5	4
271	R:R:C43	R:R:I39	1.64	No	No	0	4	8
272	R:R:L312	R:R:P166	1.64	No	Yes	0	6	6
273	R:R:C207	R:R:I275	1.64	No	No	0	7	7
274	R:R:A25	R:R:I77	1.62	No	No	0	5	6
275	R:R:S45	R:R:V41	1.62	No	Yes	0	6	7
276	R:R:A276	R:R:I328	1.62	No	No	0	6	8
277	R:R:A318	R:R:I315	1.62	No	No	0	8	6
278	R:R:V37	R:R:V41	1.6	No	Yes	0	6	7
279	R:R:V40	R:R:V41	1.6	No	Yes	0	5	7
280	R:R:V200	R:R:V204	1.6	No	No	0	6	4
281	R:R:A314	R:R:L288	1.58	No	No	0	7	7
282	R:R:P300	R:R:Q299	1.58	No	No	0	1	2
283	R:R:E303	R:R:P310	1.57	No	No	0	3	4
284	R:R:I29	R:R:V33	1.54	No	No	0	5	5
285	R:R:I196	R:R:V200	1.54	No	No	0	7	6
286	R:R:K308	R:R:S307	1.53	No	No	0	4	4
287	R:R:L331	R:R:V336	1.49	No	No	0	6	7
288	R:R:L153	R:R:M156	1.41	No	No	0	8	5
289	R:R:A152	R:R:F97	1.39	No	No	0	6	7
290	R:R:L36	R:R:L66	1.38	No	Yes	0	5	8
291	R:R:F194	R:R:L195	1.22	No	Yes	0	4	8
292	R:R:F217	R:R:Q216	1.17	No	No	0	4	5
293	R:R:R219	R:R:R220	1.07	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P24	3.9075	4	4	7
2	R:R:V41	1.86	4	0	7
3	R:R:E51	10.81	4	0	7
4	R:R:F54	5.20143	7	1	8
5	R:R:V58	3.75	4	1	8
6	R:R:D65	7.025	4	3	9
7	R:R:L66	5.565	4	3	8
8	R:R:Y80	5.242	5	4	6
9	R:R:W85	7.656	5	5	6
10	R:R:P86	3.842	5	5	4
11	R:R:L91	5.2725	4	5	6
12	R:R:F101	7.47	4	0	7
13	R:R:F102	7.242	5	0	7
14	R:R:I110	4.98	4	1	8
15	R:R:S114	4.7	4	1	9
16	R:R:E116	6.12	4	1	9
17	R:R:R117	5.43625	8	1	9
18	R:R:Y118	7.7625	4	6	8
19	R:R:I121	5.2075	4	0	9
20	R:R:N122	6.39	4	6	7
21	R:R:A136	2.955	4	0	8
22	R:R:P166	6.955	4	0	6
23	R:R:W169	9.086	5	2	5
24	R:R:F171	8.4175	4	2	6
25	R:R:D173	9.6175	4	2	5
26	R:R:W174	10.2314	7	2	5
27	R:R:H181	7.87	4	2	5
28	R:R:Y184	8.7075	4	7	8
29	R:R:Y188	5.654	5	0	7
30	R:R:L195	4.2825	4	0	8
31	R:R:T199	4.63833	6	1	8
32	R:R:L274	3.6275	4	1	8
33	R:R:S278	4.56	4	1	8
34	R:R:R291	6.63	4	0	6
35	R:R:D311	8.2625	4	2	6
36	R:R:N321	7.066	5	0	9
37	R:R:P322	6.5475	4	3	9
38	L:L:?1	10.647	10	4	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F28	R:R:T69	13.0421	3.89	No	No	3	6	8
2	R:R:P322	R:R:T69	16.009	3.5	Yes	No	3	9	8
3	R:R:N321	R:R:P322	85.7836	4.89	Yes	Yes	0	9	9
4	R:R:C284	R:R:N321	12.4725	9.45	No	Yes	0	9	9
5	R:R:C284	R:R:I317	11.5586	3.27	No	No	0	9	8
6	L:L:?1	R:R:I317	10.6446	14.88	Yes	No	0	0	8
7	R:R:F28	R:R:V32	12.1363	6.55	No	No	3	6	7
8	R:R:L66	R:R:V32	10.1402	2.98	Yes	No	3	8	7
9	R:R:L62	R:R:V58	12.3939	2.98	No	Yes	0	8	8
10	R:R:F54	R:R:V58	14.0374	3.93	Yes	Yes	1	8	8
11	R:R:F54	R:R:L274	46.568	4.87	Yes	Yes	1	8	8
12	R:R:L274	R:R:S278	87.0474	3	Yes	Yes	1	8	8
13	R:R:I110	R:R:S278	83.6439	3.1	Yes	Yes	1	8	8
14	R:R:I110	R:R:V281	94.2044	9.22	Yes	No	0	8	8
15	R:R:N321	R:R:V281	94.4729	5.91	Yes	No	0	9	8
16	R:R:F54	R:R:L273	10.7802	3.65	Yes	No	0	8	8
17	R:R:E51	R:R:M270	10.4711	4.06	Yes	No	0	7	9
18	R:R:L274	R:R:R117	45.1007	3.64	Yes	Yes	1	8	9
19	R:R:E116	R:R:F54	15.7893	3.5	Yes	Yes	1	9	8
20	R:R:E116	R:R:R117	15.8354	4.65	Yes	Yes	1	9	9
21	R:R:E116	R:R:T53	18.3766	8.47	Yes	No	0	9	6
22	R:R:T53	R:R:V131	10.3301	3.17	No	No	0	6	7
23	R:R:E116	R:R:Y127	11.7295	7.86	Yes	No	0	9	8
24	R:R:V131	R:R:Y127	15.2632	8.83	No	No	0	7	8
25	R:R:F101	R:R:S105	97.2934	7.93	Yes	No	0	7	8
26	R:R:F101	R:R:F102	97.5538	12.86	Yes	Yes	0	7	7
27	R:R:F102	R:R:L71	13.4923	6.09	Yes	No	0	7	6
28	R:R:L71	R:R:Y94	12.6922	4.69	No	No	0	6	5
29	R:R:I98	R:R:Y94	11.8922	10.88	No	No	0	5	5
30	R:R:I98	R:R:V72	11.6996	3.07	No	No	0	5	7
31	L:L:?1	R:R:V72	11.6155	3.11	Yes	No	0	0	7
32	R:R:P322	R:R:R106	84.8073	12.97	Yes	No	3	9	9
33	R:R:N147	R:R:S105	100	5.96	No	No	0	8	8
34	R:R:L104	R:R:N147	99.9132	6.87	No	No	0	8	8
35	R:R:L104	R:R:Y188	99.7586	8.21	No	Yes	0	8	7
36	R:R:L100	R:R:Y188	24.3213	7.03	No	Yes	0	7	7
37	R:R:L100	R:R:T96	20.6276	2.95	No	No	0	7	7
38	R:R:C170	R:R:T96	18.8593	3.38	No	No	0	9	7
39	R:R:C170	R:R:W85	17.0531	3.92	No	Yes	0	9	6
40	R:R:Q164	R:R:W169	13.8638	10.95	No	Yes	2	7	5
41	R:R:Q164	R:R:R162	15.3147	17.52	No	No	2	7	4
42	R:R:D173	R:R:R162	16.5162	16.68	Yes	No	2	5	4
43	R:R:D173	R:R:S160	44.0159	5.89	Yes	No	0	5	3
44	R:R:H181	R:R:S160	44.5394	9.76	Yes	No	0	5	3
45	R:R:G159	R:R:H181	90.7792	7.94	No	Yes	0	7	5
46	R:R:G159	R:R:P154	91.1046	4.06	No	No	0	7	9
47	R:R:P154	R:R:Y184	91.4246	12.52	No	Yes	0	9	8
48	R:R:F150	R:R:Y184	92.6477	8.25	No	Yes	0	7	8
49	R:R:F150	R:R:Y188	93.22	4.13	No	Yes	0	7	7
50	R:R:W169	R:R:W174	14.1025	3.75	Yes	Yes	2	5	5
51	R:R:T175	R:R:W174	69.4682	4.85	No	Yes	2	4	5
52	R:R:D173	R:R:T175	70.6262	4.34	Yes	No	2	5	4
53	R:R:D173	R:R:T176	44.3631	11.56	Yes	No	2	5	4
54	R:R:H181	R:R:T176	44.5339	5.48	Yes	No	2	5	4
55	R:R:I110	R:R:T199	10.0046	4.56	Yes	Yes	1	8	8
56	R:R:I121	R:R:R117	15.1412	6.26	Yes	Yes	0	9	9
57	R:R:I121	R:R:N122	12.6895	4.25	Yes	Yes	0	9	7
58	R:R:L135	R:R:V131	21.2866	4.47	No	No	0	5	7
59	R:R:L312	R:R:P166	14.6286	1.64	No	Yes	0	6	6
60	R:R:L312	R:R:W169	16.9121	7.97	No	Yes	0	6	5
61	R:R:N295	R:R:W174	15.9032	25.99	No	Yes	2	6	5
62	R:R:D311	R:R:W174	29.7318	12.28	Yes	Yes	2	6	5
63	R:R:N295	R:R:P300	14.5391	4.89	No	No	0	6	1
64	R:R:L297	R:R:Y186	11.8325	5.86	No	No	0	4	5
65	R:R:L297	R:R:Y298	14.7778	4.69	No	No	0	4	4
66	R:R:V294	R:R:Y298	17.7176	5.05	No	No	0	5	4
67	R:R:R291	R:R:V294	10.5524	7.85	Yes	No	0	6	5
68	R:R:D311	R:R:R291	20.1313	5.96	Yes	Yes	0	6	6
69	R:R:P300	R:R:V294	10.2107	5.3	No	No	0	1	5
70	R:R:E303	R:R:P310	11.8217	1.57	No	No	0	3	4
71	R:R:F102	R:R:R106	85.9111	4.28	Yes	No	0	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V21	R:R:Y80	3.79	0	No	Yes	6	6	2	1
R:R:I23	R:R:P24	3.39	0	No	Yes	6	7	2	1
R:R:I23	R:R:M27	4.37	0	No	No	6	8	2	1
R:R:P24	R:R:T76	3.5	4	Yes	No	7	8	1	1
R:R:P24	R:R:Y80	4.17	4	Yes	Yes	7	6	1	1
L:L:?1	R:R:P24	4.57	4	Yes	Yes	0	7	0	1
L:L:?1	R:R:M27	7.86	4	Yes	No	0	8	0	1
R:R:I98	R:R:V72	3.07	0	No	No	5	7	2	1
L:L:?1	R:R:V72	3.11	4	Yes	No	0	7	0	1
R:R:T76	R:R:Y80	3.75	4	No	Yes	8	6	1	1
L:L:?1	R:R:T76	14.35	4	Yes	No	0	8	0	1
R:R:R316	R:R:Y80	3.09	4	No	Yes	7	6	1	1
L:L:?1	R:R:Y80	11.41	4	Yes	Yes	0	6	0	1
R:R:C284	R:R:I317	3.27	0	No	No	9	8	2	1
L:L:?1	R:R:R316	33.78	4	Yes	No	0	7	0	1
L:L:?1	R:R:I317	14.88	4	Yes	No	0	8	0	1
L:L:?1	R:R:S319	8.35	4	Yes	No	0	8	0	1
R:R:L324	R:R:V320	4.47	0	No	No	7	5	2	1
L:L:?1	R:R:V320	5.18	4	Yes	No	0	5	0	1
L:L:?1	R:R:I283	2.98	4	Yes	No	0	7	0	1
R:R:I323	R:R:M27	2.92	0	No	No	8	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
61.54	Single	9JRO	PF-04418948	9JRO-EP₂-PF-04418948
46.67	Single	9JRT	TG6-129	9JRT-EP₂-TG6-129
43.75	Single	8GDB	PGE2	8GDB-EP₄-PGE2-Gs/β1/γ2
41.18	Single	6AK3	PGE2	6AK3-EP₃-PGE2
41.18	Single	6IIU	Ramatroban	6IIU-TXA2-Ramatroban
40.00	Single	9JQZ	Grapiprant	9JQZ-EP₄-Grapiprant
38.89	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/β1/γ2
37.50	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
37.50	Single	8ZVZ	BW245C	8ZVZ-DP₁-BW245C-Gs/β1/γ2
36.84	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/β1/γ2
36.84	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/β1/γ2
36.84	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29	Single	9E9S	PGD2	9E9S-DP₁-PGD2-Gs/β1/γ1
35.00	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/β1/γ2
33.33	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/β1/γ2
33.33	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/β1/γ2
33.33	Single	8XJN	Cloprosetnol	8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33	Single	9AU0	BW245C	9AU0-DP₁-BW245C-Gs/β1/γ2
31.58	Single	8XJK	Cloprosetnol	8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58	Single	8XJO	U46619	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58	Single	9GG5	U46619	9GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.58	Single	9M1H	PGE2	9M1H-EP₁-PGE2-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58	Consensus	prostanoid_on	Orthosteric Ligand	tp_on fp-alpha_on
31.58	Consensus	prostanoid_on_gp	Orthosteric Ligand	tp_on_gp fp-alpha_on_gp
31.58	Consensus	tp_on	Orthosteric Ligand	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58	Consensus	tp_on_gp	Orthosteric Ligand	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25	Single	6IIV	Daltroban	6IIV-TXA2-Daltroban
29.41	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
29.41	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
29.41	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/β1/γ2
29.41	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
29.41	Consensus	ep_off	Orthosteric Ligand	ep4_off
28.57	Single	7LD3	MIPS521	7LD3-A₁-Adenosine-MIPS521-Gi2/β1/γ2
27.78	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/β1/γ2
27.78	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
27.78	Single	8ZW0	PGD2	8ZW0-DP₁-PGD2-Gs/β1/γ2
26.32	Single	9GGG	I-BOP	9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00	Single	7D7M	PGE2	7D7M-EP₄-PGE2-Gs/β1/γ1
25.00	Consensus	fp-alpha_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00	Consensus	fp-alpha_on_gp	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
23.53	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
22.22	Single	9EE5	ONO-2550289	9EE5-DP₁-ONO-2550289
22.22	Single	9EKH	ONO-3030297	9EKH-DP₁-ONO-3030297
22.22	Consensus	s1p5_off	Orthosteric Ligand	7YXA-S1P₅-ONO-5430608
21.05	Single	8YNT	SNAP-94847	8YNT-MCH1-SNAP-94847
20.00	Single	7XKF	Dehydroepiandrosterone	7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
20.00	Single	8YKD	Dehydroepiandrosterone	8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
20.00	Single	9BJK	PubChem 171642066	9BJK-μ-Naloxone-PubChem 171642066
19.05	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75	Single	5U09	Taranabant	5U09-CB₁-Taranabant
18.75	Single	8HMP	C17	8HMP-GPR52-C17-Gs/β1/γ2
18.75	Single	9K6L	Salicin	9K6L-TAS2R16-Salicin-Gi2/β1/γ2
17.65	Single	8K2W	AMG487	8K2W-CXCR3-AMG487
17.65	Consensus	cb1_off	Orthosteric Ligand	5U09-CB₁-Taranabant 5TGZ-CB₁-AM6538
17.65	Consensus	cxcr3_off	Orthosteric Ligand	8K2W-CXCR3-AMG487
16.67	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
16.67	Single	6KPF	AM12033	6KPF-CB₂-AM12033-Gi1/β1/γ2
16.67	Single	8GCM	L-902688	8GCM-EP₄-L-902688-Gi1/β1/γ2
16.67	Single	9IVG	GLP-1 (Truncated)	9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
15.79	Single	5T1A	BMS-681	5T1A-CCR2-BMS-681-PubChem 12093170
15.79	Single	6KPC	AM12033	6KPC-CB₂-AM12033
15.79	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/β1/γ2
15.79	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
15.79	Single	8YNS	SNAP-94847	8YNS-MCH1-SNAP-94847
15.79	Single	9B9Z	MRI-1867	9B9Z-CB₁-MRI-1867
15.79	Single	9ERX	D9-THC analog	9ERX-CB₁-D9-THC analog-Gi1/β1/γ2
15.38	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2; STE2-α-factor mating pheromone-Gi1/STE4/γ2
15.00	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/β1/γ2
15.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
15.00	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/β1/γ2
15.00	Single	8JD5	JNJ-40411813; ADX88178	8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
15.00	Single	9RHG	C407	9RHG-FZD₇-C407
14.81	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2; STE2-α-factor mating pheromone
14.29	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
14.29	Single	6KQI	CP55940	6KQI-CB₁-CP55940-Org27569
14.29	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2; STE2-α-factor mating pheromone
14.29	Consensus	cannabinoid_on	Orthosteric Ligand	cb2_on cb1_on
14.29	Consensus	cannabinoid_on_gp	Orthosteric Ligand	cb2_on_gp cb1_on_gp
14.29	Consensus	cb1_on	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
13.64	Consensus	cb1_on_gp	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
13.33	Single	8Y6W	4-CMTB	8Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
12.50	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
12.50	Single	6LI0	C17	6LI0-GPR52-C17
12.50	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/β1/γ2
12.50	Single	7QA8	Antagonist Peptide	7QA8-STE2; STE2-Antagonist Peptide
12.50	Single	7QA8	Antagonist Peptide	7QA8-STE2; STE2-Antagonist Peptide
12.50	Single	8GHV	AMG315	8GHV-CB₁-AMG315-Gi1/β1/γ2
12.50	Single	8YKW	Succinic acid	8YKW-Succinate-Succinic acid-Gi1/β1/γ1
12.50	Single	9B9Y	Taranabant	9B9Y-CB₁-Taranabant
12.50	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg4_on
12.50	Consensus	adgrg_on_gp	Orthosteric Ligand	adgrg2_on_gp adgrg4_on_gp
12.00	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
11.76	Single	7VVO	PTH	7VVO-PTH1-PTH-Gs/β1/γ2
11.76	Single	8JPP	Succinic acid	8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
11.76	Single	8WOG	Succinic acid	8WOG-Succinate-Succinic acid-Gi1/β1/γ2
11.76	Single	8YKX	Maleic acid	8YKX-Succinate-Maleic acid-Gi1/β1/γ1
11.76	Single	9CLW	4-CMTB	9CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76	Consensus	angiotensin_off	Orthosteric Ligand	at1_off
11.76	Consensus	gi_succinate	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
11.76	Consensus	succinate_on	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
11.76	Consensus	succinate_on_gp	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
11.54	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
11.11	Single	4ZUD	Olmesartan	4ZUD-AT₁-Olmesartan
11.11	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
11.11	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
11.11	Single	8HNM	VUF11222	8HNM-CXCR3-VUF11222-Gi1/β1/γ2
11.11	Single	8YW3	Retatrutide	8YW3-GLP-1-Retatrutide-Gs/β1/γ2
11.11	Single	8ZPM	AMD070	8ZPM-CXCR4-AMD070
11.11	Single	9BA0	MRI-1891	9BA0-CB₁-MRI-1891
11.11	Single	9EPQ	11,20-Ethanoretinal	9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
11.11	Single	9JFU	NE52-QQ57	9JFU-GPR4-NE52-QQ57
11.11	Single	9JH3	CMF-019	9JH3-Apelin; Apelin-CMF-019-Gi1/β1/γ2
11.11	Single	9ODJ	Mitragynine Pseudoindoxyl	9ODJ-μ-Mitragynine Pseudoindoxyl-GTP; Mg-Gi1/β1/γ2
11.11	Consensus	at1_off	Orthosteric Ligand	4YAY-AT₁-ZD-7155 4ZUD-AT₁-Olmesartan
10.71	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
10.71	Single	8XQE	Apelin-13	8XQE-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
10.53	Single	2Y01	Dobutamine	2Y01-β₁-Dobutamine
10.53	Single	4YAY	ZD-7155	4YAY-AT₁-ZD-7155
10.53	Single	6ORV	TT-OAD2	6ORV-GLP-1-TT-OAD2-Gs/β1/γ2
10.53	Single	6Z10	PubChem 154585554	6Z10-Succinate-PubChem 154585554
10.53	Single	7RBT	LSN3556672	7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
10.53	Single	7T2G	Mitragynine Pseudoindoxyl	7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
10.53	Single	7V3Z	CP55940	7V3Z-CB₁-CP55940
10.53	Single	8X9T	AP503	8X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
10.53	Single	9EPP	11,20-Ethanoretinal	9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
10.53	Single	9JGK	Balovaptan	9JGK-5-HT_2B-Balovaptan
10.53	Consensus	alicarboxylic_off	Orthosteric Ligand	succinate_off
10.53	Consensus	alicarboxylic_on_gp	Orthosteric Ligand	succinate_on_gp hca_on_gp
10.53	Consensus	gi_alicarboxylic	Orthosteric Ligand	gi_hca gi_succinate
10.53	Consensus	succinate_off	Orthosteric Ligand	6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
10.34	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
10.34	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
10.00	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
10.00	Single	4JKV	Taladegib	4JKV-SMO-Taladegib
10.00	Single	4WW3	All-trans-Retinal	4WW3-Rhodopsin-All-trans-Retinal
10.00	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
10.00	Single	6GPX	MK0812	6GPX-CCR2-MK0812
10.00	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
10.00	Single	6P9X	Corticoliberin-1	6P9X-CRF₁-Corticoliberin-1-Gs/β1/γ2
10.00	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/β1/γ2
10.00	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2; STE2-α-factor mating pheromone-Gi1/STE4/γ2
10.00	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2; STE2-α-factor mating pheromone
10.00	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
10.00	Single	8HNL	PS372424	8HNL-CXCR3-PS372424-Gi1/β1/γ2
10.00	Single	8TH4	Losartan	8TH4-AT₁-Losartan-AT118-L Nanobody
10.00	Single	8W8S	AA-14	8W8S-GPR101-AA-14
10.00	Single	8XQP	Cholesterol	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
10.00	Single	8XYK	VUF10661	8XYK-CXCR3-VUF10661-Go/β1/γ2
10.00	Single	9EAH	Olmesartan	9EAH-AT₁-Olmesartan-Nanobody AT209
10.00	Single	9JKS	PubChem 44250176	9JKS-HCA₃-PubChem 44250176-Gi1/β1/γ2
10.00	Single	9KPF	Salicin	9KPF-TAS2R16-Salicin-Gi1/β1/γ2
10.00	Consensus	cb2_on	Orthosteric Ligand	8GUR-CB₂-CP55940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-AM12033-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
10.00	Consensus	cb2_on_gp	Orthosteric Ligand	8GUR-CB₂-CP55940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-AM12033-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
10.00	Consensus	s1p_off	Orthosteric Ligand	s1p1_off s1p5_off
9.68	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2; STE2-α-factor mating pheromone
9.68	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
9.52	Single	5V56	TC114	5V56-SMO-TC114
9.52	Single	5V57	TC114	5V57-SMO-TC114
9.52	Single	5XR8	AM12033	5XR8-CB₁-AM12033
9.52	Single	5XRA	AM11542	5XRA-CB₁-AM11542
9.52	Single	7FEE	CP55940	7FEE-CB₁-CP55940-ZCZ011
9.52	Single	7WV9	CP55940	7WV9-CB₁-CP55940-ZCZ011-Gi2/β1/γ2
9.52	Single	8WU1	MDMB-Fubinaca	8WU1-CB₁-MDMB-Fubinaca-Arrestin2
9.52	Single	8XZI	CMF-019	8XZI-Apelin; Apelin-CMF-019-Gi1/β1/γ2
9.52	Single	9EGO	Z8526711350	9EGO-CB₁-Z8526711350-Gi1/β1/γ2
9.52	Single	9KUX	CMPD644	9KUX-Apelin; Apelin-CMPD644-Arrestin2
9.52	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUR-CB₂-CP55940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2 6KPF-CB₂-AM12033-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 6KPG-CB₁-AM841-Gi1/β1/γ2
9.38	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
9.09	Single	6H7N	Xamoterol	6H7N-β₁-Xamoterol
9.09	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
9.09	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
9.09	Single	7JNI	Olodanrigan	7JNI-AT₂-Olodanrigan
9.09	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/β1/γ2
9.09	Single	7W0L	PubChem 122701908	7W0L-Apelin; Apelin-PubChem 122701908-Gi1/β1/γ2
9.09	Single	8W8R	AA-14	8W8R-GPR101-AA-14-chim(NtGi1-Gs)/β1/γ2
9.09	Single	8XYI	VUF10661	8XYI-CXCR3-VUF10661
9.09	Single	9DGI	Z8526711350	9DGI-CB₁-Z8526711350
9.09	Single	9MQL	Isoquinuclidine	9MQL-κ-Isoquinuclidine
9.09	Single	9WXM	GPR15L(CT)	9WXM-GPR15-GPR15L(CT)-Gi3/β1/γ2
9.09	Consensus	cannabinoid_off	Orthosteric Ligand	cb2_off cb1_off
9.09	Consensus	lipid_offon	Orthosteric Ligand	lipid_off lipid_on
9.09	Consensus	lipid_offon_gp	Orthosteric Ligand	lipid_on_gp lipid_off
8.82	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
8.82	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
8.70	Single	5UNG	PubChem 15780052	5UNG-AT₂-PubChem 15780052
8.70	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
8.70	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/β1/γ2
8.70	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/β1/γ2
8.70	Single	7P00	Substance-P	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/β1/γ2
8.70	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
8.70	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
8.70	Single	8GAG	Z8526711350	8GAG-CB₁-Z8526711350-Gi1/β1/γ2
8.70	Single	8K2X	CXCL10	8K2X-CXCR3-CXCL10-Gi1/β1/γ2
8.70	Single	8WRZ	AM841	8WRZ-CB₁-AM841-Arrestin2
8.70	Single	9EAI	Losartan	9EAI-AT₁-Losartan-Nanobody AT209
8.70	Single	9HYI	DP81	9HYI-5-HT_1A-DP81-Gi1/β1/γ2
8.70	Consensus	beta1_on	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
8.70	Consensus	beta1_on_gp	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
8.70	Consensus	nk1_on	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70	Consensus	nk1_on_gp	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70	Consensus	prostanoid_off	Orthosteric Ligand	ep_off dp_off
8.57	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
8.57	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/β1/γ2
8.57	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/β1/γ2
8.57	Consensus	glucagon_on	Orthosteric Ligand	glp_on gluc_on secretin_on gip_on
8.33	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
8.33	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/β1/γ2
8.33	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
8.33	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Single	7RMG	Substance-P	7RMG-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
8.33	Single	7RMH	Substance-P	7RMH-NK₁-Substance-P-Gs/β1/γ2
8.33	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
8.33	Single	8X3L	XWD	8X3L-CB₂-XWD-Gi1/β1/γ2
8.33	Single	8XQO	Cholesterol	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
8.33	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
8.33	Consensus	cxcr3_on	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
8.33	Consensus	gluc_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
8.33	Consensus	glucagon_on_gp	Orthosteric Ligand	glp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
8.11	Consensus	gluc_on_gp	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
8.11	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
8.11	Consensus	mc2_on_gp	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
8.00	Single	4AMJ	Carvedilol	4AMJ-β₁-Carvedilol
8.00	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
8.00	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
8.00	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/β1/γ2
8.00	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/β1/γ2
8.00	Single	8FYL	Vilazodone	8FYL-5-HT_1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
8.00	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/β1/γ2
8.00	Single	8KIG	SHU9119	8KIG-MC₃-SHU9119-Ca
8.00	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Gi1/β1/γ2
8.00	Single	8YWF	Retatrutide	8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
8.00	Single	9M4T	Silodosin	9M4T-Alpha1A-Silodosin
8.00	Consensus	cxcr4_on	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
7.89	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on vip-pacap_on pth_on crf_on calcitonin_on
7.69	Single	4A4M	All-trans-Retinal	4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
7.69	Single	5EN0	All-trans-Retinal	5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
7.69	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
7.69	Single	7PIV	Afamelanotide	7PIV-MC₄-Afamelanotide-Gs/β1/γ2
7.69	Single	7RKM	CX3CL1	7RKM-US28-CX3CL1-Gi1/β1/γ2
7.69	Single	7RMI	Substance-P	7RMI-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
7.69	Single	7W0N	Elabela	7W0N-Apelin; Apelin-Elabela-Gi1/β1/γ2
7.69	Single	8IOC	Gamma-MSH	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.69	Single	8JBH	Substance-P	8JBH-NK₃-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/β1/γ2
7.69	Consensus	mc4_on_gp	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
7.41	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
7.41	Single	7F4D	Alpha-MSH	7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2
7.41	Single	8W8Y	Gamma-MSH	8W8Y-MC₃-γ-MSH-Ca-Gs/β1/γ2
7.41	Single	8XZG	Apelin-13	8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
7.41	Single	8YFO	Ac-LA-PTH Analog	8YFO-PTH1-Ac-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
7.41	Single	9IVM	GLP-1 (Truncated)	9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
7.41	Consensus	cxcr4_on_gp	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
7.41	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.41	Consensus	mc3_on_gp	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.14	Single	3PXO	All-trans-Retinal	3PXO-Rhodopsin-All-trans-Retinal
7.14	Single	5DYS	All-trans-Retinal	5DYS-Rhodopsin-All-trans-Retinal
7.14	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
7.14	Single	6NIY	Calcitonin-1	6NIY-CT-Calcitonin-1-Gs/β1/γ2
7.14	Single	6VCB	LSN3160440	6VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
7.14	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/β1/γ2
7.14	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
7.14	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
7.14	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
7.14	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/β1/γ2
7.14	Single	7XKD	Dehydroepiandrosterone	7XKD-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
7.14	Single	8X9S	5alpha-DHT	8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
7.14	Single	8YW4	Retatrutide	8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
7.14	Single	8YW5	Retatrutide	8YW5-Glucagon-Retatrutide-Gs/β1/γ2
7.14	Single	9JID	Niacin	9JID-HCA₃-Niacin-Gi1/β1/γ2
7.14	Single	9JKV	PubChem 2736690	9JKV-HCA₃-PubChem 2736690-Gi1/β1/γ2
7.14	Consensus	class-b1_on_gp	Orthosteric Ligand	glucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
7.14	Consensus	cxcr3_on_gp	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
7.14	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on nk3_on
6.98	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
6.90	Single	5YQZ	NNC1702	5YQZ-Glucagon-NNC1702
6.90	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/β1/γ2
6.90	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/β1/γ2
6.90	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
6.90	Single	7P02	Substance-P	7P02-NK₁-Substance-P-chim(NtGi1-Gs)/β1/γ2
6.90	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/β1/γ2
6.90	Consensus	chemokine_off	Orthosteric Ligand	ccr_off cxcr_off
6.90	Consensus	cml1_on_gp	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
6.90	Consensus	cxcr_off	Orthosteric Ligand	cxcr3_off cxcr4_off
6.90	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
6.90	Consensus	mc1_on_gp	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
6.90	Consensus	vpac1_on	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
6.67	Single	2HPY	All-trans-Retinal	2HPY-Rhodopsin-All-trans-Retinal
6.67	Single	6NBI	LA-PTH Analog	6NBI-PTH1-LA-PTH Analog-Gs/β1/γ2
6.67	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
6.67	Single	6OY9	All-trans-Retinal	6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.67	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/β1/γ2
6.67	Single	7MTB	All-trans-Retinal	7MTB-Rhodopsin-All-trans-Retinal-GRK1
6.67	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
6.67	Single	7VAB	Tirzepatide (non-acylated)	7VAB-GIP-Tirzepatide (non-acylated)-chim(NtGi1-Gs)/β1/γ2
6.67	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
6.67	Single	8DPH	Lorcaserin	8DPH-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
6.67	Single	8GEI	Constrained Epinephrine	8GEI-β₂-Constrained Epinephrine-Gs/β1/γ2
6.67	Single	8IWM	2-Phenylethylamine	8IWM-TAA9-2-Phenylethylamine
6.67	Single	8WC5	Tetramethylammonium Ion	8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
6.67	Single	8XQF	Apelin-13	8XQF-Apelin-Apelin-13-Gi1/β1/γ2
6.67	Single	8Y02	All-trans-Retinal	8Y02-OPN1SW-All-trans-Retinal-Gi1/β1/γ2
6.67	Single	8Z8A	Lactate	8Z8A-HCA₁-Lactate-Gi1/β1/γ2
6.67	Single	9EE9	Adenosine	9EE9-A_2A-Adenosine-Gs/β1/γ2
6.67	Single	9IVM	LSN3318839	9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
6.67	Single	9J1P	g1:Ox	9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
6.67	Consensus	opsins_on	Orthosteric Ligand	rhodopsin_on opsin1lw_on
6.67	Consensus	pac1_on	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
6.67	Consensus	pac1_on_gp	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
6.67	Consensus	secretin_on	Orthosteric Ligand	7D3S-Secretin-Secretin-Gs/β1/γ2
6.67	Consensus	sensory_on	Orthosteric Ligand	opsins_on
6.67	Consensus	vpac1_on_gp	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
6.45	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/β1/γ2
6.45	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
6.45	Single	7EIB	Kallidin-des-Arg10	7EIB-BK₁-Kallidin-des-Arg10-chim(NtGi1-Gs-CtGq)/β1/γ2
6.45	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
6.45	Single	7F53	Alpha-MSH	7F53-MC₄-α-MSH-Gs/β1/γ2
6.45	Single	7S1M	Exendin-4-D-Ala	7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2
6.45	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/β1/γ2
6.45	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
6.45	Single	8FU6	ZP3780	8FU6-Glucagon-ZP3780-Gs/β1/γ2
6.45	Single	8W8W	Alpha-MSH	8W8W-MC₃-α-MSH-Ca-Gs/β1/γ2
6.45	Single	8W8X	Beta-MSH	8W8X-MC₃-β-MSH-Ca-Gs/β1/γ2
6.45	Single	8ZJG	Chemerin	8ZJG-CML1-Chemerin-Gi1/β1/γ2
6.45	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
6.45	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
6.45	Consensus	glp2_on_gp	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
6.45	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
6.45	Consensus	glp_on_gp	Orthosteric Ligand	glp1_on_gp glp2_on_gp
6.45	Consensus	secretin_on_gp	Orthosteric Ligand	7D3S-Secretin-Secretin-Gs/β1/γ2
6.25	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
6.25	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
6.25	Single	3C9M	11-cis-Retinal	3C9M-Rhodopsin-11-cis-Retinal
6.25	Single	3PQR	All-trans-Retinal	3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
6.25	Single	3UZA	GTPL9236	3UZA-A_2A-GTPL9236
6.25	Single	6FUF	All-trans-Retinal	6FUF-Rhodopsin-All-trans-Retinal-Go
6.25	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/β1/γ2
6.25	Single	6LML	Glucagon	6LML-Glucagon-Glucagon-Gi1/β1/γ1
6.25	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/β1/γ2
6.25	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/β1/γ2
6.25	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/β1/γ2
6.25	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
6.25	Single	7EJK	Oxymetazoline	7EJK-α_2a-Oxymetazoline-Go/β1/γ2
6.25	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/β1/γ2
6.25	Single	7MT8	All-trans-Retinal	7MT8-Rhodopsin-All-trans-Retinal-GRK1
6.25	Single	7MT9	All-trans-Retinal	7MT9-Rhodopsin-All-trans-Retinal-GRK1
6.25	Single	7MTA	All-trans-Retinal	7MTA-Rhodopsin-All-trans-Retinal-GRK1
6.25	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
6.25	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/β1/γ2
6.25	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
6.25	Single	8ITF	DMCHA	8ITF-TAA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
6.25	Single	8IU2	All-trans-Retinal	8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
6.25	Single	8IW7	2-Phenylethylamine	8IW7-TAA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
6.25	Single	8J6Q	Beta-Hydroxybutyrate	8J6Q-HCA₂-β-Hydroxybutyrate-PubChem 25101223-Gi1/β1/γ2
6.25	Single	8JEF	PubChem 11367166	8JEF-HCA₃-PubChem 11367166-Gi1/β1/γ2
6.25	Single	8JXT	Histamine	8JXT-H₄-Histamine-PO4-Gi1/β1/γ2
6.25	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
6.25	Single	8WC9	ZH8651	8WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25	Single	8X9U	Metenolone	8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
6.25	Single	8YN9	Histamine	8YN9-H₄-Histamine-Gi1/β1/γ2
6.25	Single	8YUU	Histamine	8YUU-H₃-Histamine-Gi1/β1/γ1
6.25	Single	9BTW	Cagrilintide	9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
6.25	Single	9IJR	C17	9IJR-GPR52-C17-Arrestin2
6.25	Single	9IV1	5alpha-DHT	9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.25	Single	9JG1	Adriforant	9JG1-H₄-Adriforant
6.25	Single	9JKT	(2R)-2-hydroxy-3-phenylpropanoic acid	9JKT-HCA₃-(2R)-2-hydroxy-3-phenylpropanoic acid-Gi1/β1/γ2
6.25	Single	9KT9	3,5-DHBA	9KT9-HCA₁-3,5-DHBA-Gi1/β1/γ2
6.25	Single	9LRC	Histamine	9LRC-H₄-Histamine
6.25	Single	9LRE	Histamine	9LRE-H₄-Histamine-Gi1/β1/γ2
6.25	Single	9MBC	AZ12216052	9MBC-mGlu8; mGlu8-DCPG-AZ12216052
6.25	Consensus	bk2_on	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
6.25	Consensus	bk2_on_gp	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
6.25	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on
6.25	Consensus	bradykinin_on_gp	Orthosteric Ligand	bk2_on_gp
6.25	Consensus	gi_opsins	Orthosteric Ligand	8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
6.25	Consensus	gi_sensory	Orthosteric Ligand	gi_opsins
6.25	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
6.25	Consensus	gs_melanocortin	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2 8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2
6.25	Consensus	h3_on	Orthosteric Ligand	8YUU-H₃-Histamine-Gi1/β1/γ1
6.25	Consensus	h3_on_gp	Orthosteric Ligand	8YUU-H₃-Histamine-Gi1/β1/γ1
6.25	Consensus	opsin1lw_on	Orthosteric Ligand	8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
6.25	Consensus	opsin1lw_on_gp	Orthosteric Ligand	8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
6.25	Consensus	opsins_on_gp	Orthosteric Ligand	rhodopsin_on_gp opsin1lw_on_gp
6.25	Consensus	rhodopsin_on	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.25	Consensus	sensory_on_gp	Orthosteric Ligand	opsins_on_gp
6.25	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
6.25	Consensus	vpac2_on_gp	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
6.06	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2
6.06	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
6.06	Consensus	gip_on	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
6.06	Consensus	gip_on_gp	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
5.88	Single	1L9H	11-cis-Retinal	1L9H-Rhodopsin-11-cis-Retinal
5.88	Single	1U19	11-cis-Retinal	1U19-Rhodopsin-11-cis-Retinal
5.88	Single	2G87	All-trans-Retinal	2G87-Rhodopsin-All-trans-Retinal
5.88	Single	2I35	11-cis-Retinal	2I35-Rhodopsin-11-cis-Retinal
5.88	Single	3AYM	All-trans-Retinal	3AYM-Rhodopsin-All-trans-Retinal
5.88	Single	3PBL	Eticlopride	3PBL-D₃-Eticlopride
5.88	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
5.88	Single	6I9K	9-cis-Retinal	6I9K-Rhodopsin-9-cis-Retinal
5.88	Single	6LPB	PACAP27	6LPB-PAC₁-PACAP27-Gs/β1/γ1
5.88	Single	6QNO	All-trans-Retinal	6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
5.88	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/β1/γ2
5.88	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88	Single	7DFL	Histamine	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
5.88	Single	7E2Y	Serotonin	7E2Y-5-HT_1A-Serotonin-PtdIns4P-Gi1/β1/γ2
5.88	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
5.88	Single	7XP6	Strychnine	7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
5.88	Single	7YFD	Imetit	7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/β1/γ2
5.88	Single	8FLU	LA-PTH Analog	8FLU-PTH1-LA-PTH Analog-Gs/β1/γ2
5.88	Single	8GGY	Constrained Epinephrine	8GGY-β₂-Constrained Epinephrine
5.88	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/β1/γ2
5.88	Single	8HN8	Histamine	8HN8-H₄-Histamine-Gi1/β1/γ2
5.88	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/β1/γ2
5.88	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/β1/γ2
5.88	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/β1/γ2
5.88	Single	8JPN	Cis-Epoxysuccinic acid	8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
5.88	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
5.88	Single	8UO3	Constrained Epinephrine	8UO3-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
5.88	Single	8W89	2-Phenylethylamine	8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2
5.88	Single	8WP1	Cis-Epoxysuccinic acid	8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
5.88	Single	8YH3	N-methyladenosine	8YH3-A_3A-N-methyladenosine-Gi1/β1/γ2
5.88	Single	8YN4	Histamine	8YN4-H₂-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88	Single	8YN5	Histamine	8YN5-H₃-Histamine-Gi1/β1/γ2
5.88	Single	8YN6	Imetit	8YN6-H₃-Imetit-Gi1/β1/γ2
5.88	Single	8YN7	Immethridine	8YN7-H₃-Immethridine-Go/β1/γ2
5.88	Single	9EPR	All-trans-Retinal	9EPR-Rhodopsin-All-trans-Retinal-Gi1/β1/γ2
5.88	Single	9IQT	Niacin	9IQT-HCA₂-Niacin-Gi1/β1/γ2
5.88	Single	9IXJ	Histamine	9IXJ-H₂-Histamine-Gs/β1/γ2
5.88	Single	9IZD	CHBA	9IZD-HCA₁-CHBA-Gi1/β1/γ2
5.88	Single	9JED	Histamine	9JED-H₄-Histamine-PO4-Gi1/β1/γ2
5.88	Single	9JEQ	Histamine	9JEQ-H₃-Histamine-Gi1/β1/γ2
5.88	Single	9JLC	AVE 0991	9JLC-MAS1-AVE 0991-Gi1/β1/γ2
5.88	Single	9L42	Histamine	9L42-H₄-Histamine-Gi1/β1/γ2
5.88	Single	9LMP	NE52-QQ57	9LMP-GPR4-NE52-QQ57
5.88	Single	9MBC	AZ12216052	9MBC-mGlu8; mGlu8-DCPG-AZ12216052
5.88	Single	9U9V	METH	9U9V-β₂-METH-Gs/β1/γ2
5.88	Single	9YDA	All-trans-Retinal	9YDA-Opsin1MW-All-trans-Retinal-chim(NtGi1L-Gs-CtGt)/β1/γ2
5.88	Consensus	d3_off	Orthosteric Ligand	3PBL-D₃-Eticlopride
5.88	Consensus	glp1_on	Orthosteric Ligand	7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
5.88	Consensus	h1_on	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
5.88	Consensus	h4_on	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2 8JXX-H₄-Clobenpropit-Gi1/β1/γ2
5.88	Consensus	melanocortin_on	Orthosteric Ligand	mc1_on mc4_on mc2_on mc3_on mc5_on
5.88	Consensus	melanocortin_on_gp	Orthosteric Ligand	mc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
5.71	Single	6WPW	ZP3780	6WPW-Glucagon-ZP3780-Gs/β1/γ2
5.71	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/β1/γ2
5.71	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/β1/γ2
5.71	Single	9JR2	PTH	9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.71	Consensus	crf_on_gp	Orthosteric Ligand	crf2_on_gp crf1_on_gp
5.71	Consensus	glp1_on_gp	Orthosteric Ligand	7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
5.71	Consensus	pth1_on_gp	Orthosteric Ligand	6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
5.56	Single	1GZM	11-cis-Retinal	1GZM-Rhodopsin-11-cis-Retinal
5.56	Single	2PED	9-cis-Retinal	2PED-Rhodopsin-9-cis-Retinal
5.56	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
5.56	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
5.56	Single	3C9L	11-cis-Retinal	3C9L-Rhodopsin-11-cis-Retinal
5.56	Single	4S0V	Suvorexant	4S0V-OX₂-Suvorexant
5.56	Single	5WS3	EMPA	5WS3-OX₂-EMPA
5.56	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
5.56	Single	6AKX	A4R	6AKX-CCR5-A4R
5.56	Single	6AKY	Maraviroc	6AKY-CCR5-Maraviroc
5.56	Single	6B73	MP1104	6B73-κ-MP1104
5.56	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/β1/γ2
5.56	Single	6KUY	PubChem 145704643	6KUY-α_2a-PubChem 145704643
5.56	Single	6OYA	All-trans-Retinal	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.56	Single	6RNK	NF-56-EJ40	6RNK-Succinate-NF-56-EJ40
5.56	Single	6TOD	EMPA	6TOD-OX₁-EMPA-Na
5.56	Single	6TPJ	Suvorexant	6TPJ-OX₂-Suvorexant
5.56	Single	7DHR	Isoprenaline	7DHR-β₂-Isoprenaline-Gs/β1/γ2
5.56	Single	7EJ0	Norepinephrine	7EJ0-α_2a-Norepinephrine-Go/β1/γ2
5.56	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/β1/γ2
5.56	Single	7LJD	Dopamine	7LJD-D₁-Dopamine-Mevidalen-Gs/β1/γ1
5.56	Single	7T8X	Acetylcholine	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.56	Single	7T90	Acetylcholine	7T90-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.56	Single	7T96	Acetylcholine	7T96-M₂-Acetylcholine-LY2119620-Go/β1/γ2
5.56	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
5.56	Single	7Y36	PTH	7Y36-PTH1-PTH-Gs/β1/γ2
5.56	Single	7YM8	Oxymetazoline	7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
5.56	Single	7YMH	Norepinephrine	7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
5.56	Single	8A6C	All-trans-Retinal	8A6C-Rhodopsin-All-trans-Retinal
5.56	Single	8A6D	All-trans-Retinal	8A6D-Rhodopsin-All-trans-Retinal
5.56	Single	8A6E	All-trans-Retinal	8A6E-Rhodopsin-All-trans-Retinal
5.56	Single	8DWG	ML382	8DWG-MRGPRX1-BAM8-22-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56	Single	8EFO	PZM21	8EFO-μ-PZM21-Gi1/β1/γ2
5.56	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/β1/γ2
5.56	Single	8FYX	Buspirone	8FYX-5-HT_1A-Buspirone-PtdIns4P-Gi1/β1/γ1
5.56	Single	8GGA	Constrained Epinephrine	8GGA-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8GGC	Constrained Epinephrine	8GGC-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8GGR	Constrained Epinephrine	8GGR-β₂-Constrained Epinephrine
5.56	Single	8GGW	Constrained Epinephrine	8GGW-β₂-Constrained Epinephrine
5.56	Single	8GGZ	Constrained Epinephrine	8GGZ-β₂-Constrained Epinephrine
5.56	Single	8GH0	Constrained Epinephrine	8GH0-β₂-Constrained Epinephrine
5.56	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/β1/γ2
5.56	Single	8HOC	Imetit	8HOC-H₄-Imetit-Gi1/β1/γ2
5.56	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/β1/γ2
5.56	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/β1/γ2
5.56	Single	8IW4	Spermidine	8IW4-TAA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
5.56	Single	8IWE	Spermidine	8IWE-TAA9-Spermidine
5.56	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/β1/γ2
5.56	Single	8TZQ	Dopamine	8TZQ-D₂-Dopamine-Go/β1/γ2
5.56	Single	8U4P	AMD3100	8U4P-CXCR4-AMD3100-Gi1/β1/γ2
5.56	Single	8UNX	Constrained Epinephrine	8UNX-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8UTD	MK1903	8UTD-HCA₂-MK1903-Gi1/β1/γ2
5.56	Single	8WC3	SEP-363856	8WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
5.56	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
5.56	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
5.56	Single	8XXV	Indomethacin	8XXV-DP₂-Indomethacin-A1D5Q-Gi1/β1/γ2
5.56	Single	8Y0H	VUF11418	8Y0H-CXCR3-VUF11418
5.56	Single	8Y0N	VUF11418	8Y0N-CXCR3-VUF11418-Go/β1/γ2
5.56	Single	8YNA	Immepip	8YNA-H₄-Immepip-Gi1/β1/γ2
5.56	Single	8YUV	Immepip	8YUV-H₃-Immepip-Gi1/β1/γ2
5.56	Single	8Z87	CHBA	8Z87-HCA₁-CHBA-Gi1/β1/γ2
5.56	Single	9EBH	Adenosine	9EBH-A_3A-Adenosine-Gi1/β1/γ2
5.56	Single	9JKX	Acifran	9JKX-HCA₃-Acifran-Gi1/β1/γ2
5.56	Single	9JR3	PTH	9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.56	Single	9KPE	Salicin	9KPE-TAS2R16-Salicin-Gi1/β1/γ2
5.56	Single	9KVH	Cinobufotenine	9KVH-5-HT_1A-Cinobufotenine-PtdIns4P-Gi1/β1/γ2
5.56	Single	9L8L	Atazanavir	9L8L-β₂-BI167107-Atazanavir-Gs/β1/γ2 ; Arrestin2
5.56	Single	9LKD	PL45	9LKD-OR5V1-PL45
5.56	Single	9MQJ	Isoquinuclidine	9MQJ-μ-Isoquinuclidine
5.56	Single	9PXU	Naloxone	9PXU-μ-Naloxone-Na
5.56	Single	9VJ5	Gepirone	9VJ5-5-HT_1A-Gepirone-Go/β1/γ2
5.56	Single	9VJE	Buspirone	9VJE-5-HT_1A-Buspirone-Go/β1/γ2
5.56	Single	9W49	U-50488H	9W49-κ-U-50488H-Gi1/β1/γ2
5.56	Consensus	5ht1e_on	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
5.56	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
5.56	Consensus	a1_on_gp	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
5.56	Consensus	alpha2_off	Orthosteric Ligand	alpha2c_off
5.56	Consensus	class-a_class-b1_cons_on_gp	Orthosteric Ligand	class-a_on_gp class-b1_on_gp
5.56	Consensus	gq_histamine	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
5.56	Consensus	h1_on_gp	Orthosteric Ligand	7DFL-H₁-Histamine-chim(NtGi1L-Gq)/β1/γ2
5.56	Consensus	histamine_on	Orthosteric Ligand	h1_on h2_on h3_on h4_on
5.56	Consensus	histamine_on_gp	Orthosteric Ligand	h1_on_gp h2_on_gp h3_on_gp h4_on_gp
5.56	Consensus	m2_on	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.56	Consensus	m2_on_gp	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.56	Consensus	ox1_off	Orthosteric Ligand	6TP6-OX₁-Filorexant 6TP4-OX₁-ACT-462206 6V9S-OX₁-GTPL11403 6TOT-OX₁-Lemborexant 6TP3-OX₁-Nemorexant 6TQ6-OX₁-PubChem 145714283 6TQ9-OX₁-SB-408124 4ZJC-OX₁-SB-674042 4ZJ8-OX₁-Suvorexant 6TOD-OX₁-EMPA-Na 6TOS-OX₁-GSK1059865-Na 6TQ4-OX₁-PubChem 16046844-Na
5.56	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491
5.56	Consensus	rhodopsin_off	Orthosteric Ligand	1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
5.56	Consensus	rhodopsin_on_gp	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.56	Consensus	sensory_offon	Orthosteric Ligand	sensory_off sensory_on
5.56	Consensus	sensory_offon_gp	Orthosteric Ligand	sensory_on_gp sensory_on
5.41	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
5.26	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
5.26	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
5.26	Single	3OAX	11-cis-Retinal	3OAX-Rhodopsin-11-cis-Retinal
5.26	Single	3UZC	PubChem 135566609	3UZC-A_2A-PubChem 135566609
5.26	Single	4DKL	Beta-Funaltrexamine	4DKL-μ-β-Funaltrexamine
5.26	Single	4LDO	Epinephrine	4LDO-β₂-Epinephrine
5.26	Single	4MBS	Maraviroc	4MBS-CCR5-Maraviroc
5.26	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
5.26	Single	4ZJC	SB-674042	4ZJC-OX₁-SB-674042
5.26	Single	6FFI	MPEP	6FFI-mGlu₅-MPEP
5.26	Single	6IQL	L745870	6IQL-D₄-L745870
5.26	Single	6K41	Dexmedetomidine	6K41-α_2b-Dexmedetomidine-Go/β1/γ2
5.26	Single	6KUX	RS79948	6KUX-α_2a-RS79948
5.26	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
5.26	Single	6PS0	Carazolol	6PS0-β₂-Carazolol
5.26	Single	6PS4	ICI118-551	6PS4-β₂-ICI118-551
5.26	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
5.26	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2
5.26	Single	6TOS	GSK1059865	6TOS-OX₁-GSK1059865-Na
5.26	Single	6TP3	Nemorexant	6TP3-OX₁-Nemorexant
5.26	Single	6TPG	EMPA	6TPG-OX₂-EMPA
5.26	Single	6V9S	GTPL11403	6V9S-OX₁-GTPL11403
5.26	Single	6VI4	JDTic	6VI4-κ-JDTic
5.26	Single	6WH4	Methiothepin	6WH4-5-HT_2A-Methiothepin
5.26	Single	6ZFZ	77-LH-28-1	6ZFZ-M₁-77-LH-28-1
5.26	Single	6ZG9	GSK1034702	6ZG9-M₁-GSK1034702
5.26	Single	7BB6	AVP	7BB6-V₂-AVP-Gs/β1/γ2
5.26	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/β1/γ2
5.26	Single	7CMU	Pramipexole	7CMU-D₃-Pramipexole-Gi1/β1/γ2
5.26	Single	7CMV	PD128907	7CMV-D₃-PD128907-Gi1/β1/γ2
5.26	Single	7DHI	Salbutamol	7DHI-β₂-Salbutamol-Gs/β1/γ2
5.26	Single	7E33	BRL-54443	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2
5.26	Single	7EJ8	Brimonidine	7EJ8-α_2a-Brimonidine-Go/β1/γ2
5.26	Single	7EJA	Dexmedetomidine	7EJA-α_2a-Dexmedetomidine-Go/β1/γ2
5.26	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/β1/γ2
5.26	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/β1/γ2
5.26	Single	7F24	Dopamine	7F24-D₁-Dopamine-GDP-Gs/β1/γ2
5.26	Single	7RAN	PubChem 164575847	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Single	7T94	Acetylcholine	7T94-M₂-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
5.26	Single	7TRS	Acetylcholine	7TRS-M₄-Acetylcholine-Gi1/β1/γ2
5.26	Single	7UM7	Methylergometrine	7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
5.26	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
5.26	Single	7ZBC	11-cis-Retinal	7ZBC-Rhodopsin-11-cis-Retinal
5.26	Single	7ZBE	11-cis-Retinal	7ZBE-Rhodopsin-11-cis-Retinal
5.26	Single	8DPG	Psilocin	8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Single	8FCZ	11-cis-Retinal	8FCZ-Rhodopsin-11-cis-Retinal
5.26	Single	8GE1	Constrained Epinephrine	8GE1-β₂-Constrained Epinephrine-Gs/β1/γ2
5.26	Single	8GE4	Constrained Epinephrine	8GE4-β₂-Constrained Epinephrine-Gs/β1/γ2
5.26	Single	8GE5	Constrained Epinephrine	8GE5-β₂-Constrained Epinephrine-Gs/β1/γ1
5.26	Single	8GE6	Constrained Epinephrine	8GE6-β₂-Constrained Epinephrine-Gs/β1/γ2
5.26	Single	8GE7	Constrained Epinephrine	8GE7-β₂-Constrained Epinephrine-Gs/β1/γ2
5.26	Single	8GE8	Constrained Epinephrine	8GE8-β₂-Constrained Epinephrine-Gs/β1/γ2
5.26	Single	8GEA	Constrained Epinephrine	8GEA-β₂-Constrained Epinephrine-Gs/β1/γ2
5.26	Single	8GED	Constrained Epinephrine	8GED-β₂-Constrained Epinephrine-Gs/β1/γ2
5.26	Single	8GEF	Constrained Epinephrine	8GEF-β₂-Constrained Epinephrine-Gs/β1/γ2
5.26	Single	8GG5	Constrained Epinephrine	8GG5-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26	Single	8GG8	Constrained Epinephrine	8GG8-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26	Single	8GGQ	Constrained Epinephrine	8GGQ-β₂-Constrained Epinephrine
5.26	Single	8GGS	Constrained Epinephrine	8GGS-β₂-Constrained Epinephrine
5.26	Single	8GGT	Constrained Epinephrine	8GGT-β₂-Constrained Epinephrine
5.26	Single	8GGV	Constrained Epinephrine	8GGV-β₂-Constrained Epinephrine
5.26	Single	8GGX	Constrained Epinephrine	8GGX-β₂-Constrained Epinephrine
5.26	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/β1/γ2
5.26	Single	8GUR	CP55940	8GUR-CB₂-CP55940-Gi1/β1/γ2
5.26	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
5.26	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/β1/γ2
5.26	Single	8JD6	VU0364770	8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.26	Single	8JEI	PubChem 11715556	8JEI-HCAR3-PubChem 11715556-Gi1/β1/γ2
5.26	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/β1/γ2
5.26	Single	8JIM	Monomethyl fumarate	8JIM-HCA₂-Monomethyl fumarate-Gi1/β1/γ2
5.26	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
5.26	Single	8JLN	T1AM	8JLN-TA1-T1AM-Gs/β1/γ2
5.26	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
5.26	Single	8PM2	DMCHA	8PM2-TA7-DMCHA-Gs/β1/γ2
5.26	Single	8THK	A-61603	8THK-Alpha1A-A-61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Single	8THL	Epinephrine	8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Single	8U02	Dopamine	8U02-D₂-Dopamine-Go/β1/γ2
5.26	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/β1/γ2
5.26	Single	8UNM	Constrained Epinephrine	8UNM-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26	Single	8UNW	Constrained Epinephrine	8UNW-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26	Single	8UO0	Constrained Epinephrine	8UO0-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/β1/γ2
5.26	Single	8W8B	SEP-363856	8W8B-5-HT_1A-SEP-363856-Gi1/β1/γ2
5.26	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
5.26	Single	8Y01	All-trans-Retinal	8Y01-Opsin1MW-All-trans-Retinal-Gi1/β1/γ2
5.26	Single	8Y45	ADL5859	8Y45-δ-ADL5859-Gi2/β1/γ2
5.26	Single	8YH2	Adenosine	8YH2-A_3A-Adenosine-Gi1/β1/γ2
5.26	Single	8YKV	PubChem 137553168	8YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
5.26	Single	8YN3	Histamine	8YN3-H₂-Histamine-Gs/β1/γ2
5.26	Single	8ZBW	Quin-C1	8ZBW-FPR2-ALX-Quin-C1-Gi2/β1/γ2
5.26	Single	8ZPN	AMD3100	8ZPN-CXCR4-AMD3100
5.26	Single	9AS3	LSD	9AS3-5-HT_2A-LSD
5.26	Single	9AS4	LSD	9AS4-5-HT_2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	9AS5	Mescaline	9AS5-5-HT_2A-Mescaline
5.26	Single	9AS6	Mescaline	9AS6-5-HT_2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	9CBL	Epinephrine	9CBL-α_2a-Epinephrine-Gi1/β1/γ2
5.26	Single	9JKY	Acifran	9JKY-HCA₂-Acifran-Gi1/β1/γ2
5.26	Single	9KPD	Salicin	9KPD-TAS2R16-Salicin-chim(Gs-CtGt3)/β1/γ2
5.26	Single	9KVI	Bufotenin	9KVI-5-HT_1A-Bufotenin-PtdIns4P-Gi1/β1/γ2
5.26	Single	9LKB	PL45	9LKB-OR5V1-PL45-chim(NtGi1-Gs)/β1
5.26	Single	9LRD	Histamine	9LRD-H₁-Histamine-Gi1/β1/γ2
5.26	Single	9MQI	Isoquinuclidine	9MQI-μ-Isoquinuclidine
5.26	Single	9ODL	Mitragynine Pseudoindoxyl	9ODL-μ-Mitragynine Pseudoindoxyl-GTP; Mg-Gi1/β1/γ2
5.26	Single	9PXV	Naloxone	9PXV-μ-Naloxone-Gi1/β1/γ2
5.26	Single	9PXX	Naloxone	9PXX-μ-Naloxone-GDPβS-Gi1/β1/γ2
5.26	Single	9PY2	Loperamide	9PY2-μ-Loperamide-GDPβS-Gi1/β1/γ2
5.26	Single	9VJG	8-OH-DPAT	9VJG-5-HT_1A-8-OH-DPAT-chim(NtGi2-Gz)/β1/γ2
5.26	Single	9VNF	Pindolol	9VNF-5-HT_1A-Pindolol-Go/β1/γ2
5.26	Single	9W6W	5-CT	9W6W-5-HT_5A-5-CT-Gi1/β1/γ2
5.26	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on a3_on
5.26	Consensus	alpha1_on	Orthosteric Ligand	alpha1a_on
5.26	Consensus	alpha1_on_gp	Orthosteric Ligand	alpha1a_on_gp
5.26	Consensus	alpha1a_on	Orthosteric Ligand	7EJ0-α_2a-Norepinephrine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2
5.26	Consensus	alpha1a_on_gp	Orthosteric Ligand	7EJ0-α_2a-Norepinephrine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2
5.26	Consensus	d3_on	Orthosteric Ligand	7CMV-D₃-PD128907-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2
5.26	Consensus	d3_on_gp	Orthosteric Ligand	7CMV-D₃-PD128907-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2
5.26	Consensus	gi_adenosine	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2 8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
5.26	Consensus	hca_on	Orthosteric Ligand	hca2_on
5.26	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
5.26	Consensus	opsins_off	Orthosteric Ligand	rhodopsin_off
5.26	Consensus	sensory_off	Orthosteric Ligand	opsins_off
5.00	Single	1HZX	11-cis-Retinal	1HZX-Rhodopsin-11-cis-Retinal
5.00	Single	2VT4	Cyanopindolol	2VT4-β₁-Cyanopindolol
5.00	Single	2Y04	Salbutamol	2Y04-β₁-Salbutamol
5.00	Single	2YCY	Cyanopindolol	2YCY-β₁-Cyanopindolol
5.00	Single	3NY8	ICI118-551	3NY8-β₂-ICI118-551
5.00	Single	3NYA	Alprenolol	3NYA-β₂-Alprenolol
5.00	Single	3ZPR	PubChem 598754	3ZPR-β₁-PubChem 598754-Na
5.00	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
5.00	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
5.00	Single	4GBR	Carazolol	4GBR-β₂-Carazolol
5.00	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
5.00	Single	4QIM	ANTA XV	4QIM-SMO-ANTA XV
5.00	Single	4QKX	PubChem 76210628	4QKX-β₂-PubChem 76210628
5.00	Single	4U16	N-methyl-Scopolamine	4U16-M₃-N-methyl-Scopolamine
5.00	Single	4X1H	Nonyl-Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
5.00	Single	5DHG	C-35	5DHG-NOP-C-35
5.00	Single	5DHH	SB-612111	5DHH-NOP-SB-612111
5.00	Single	5DSG	Tiotropium	5DSG-M₄-Tiotropium
5.00	Single	5NDD	AZ8838; Na	5NDD-PAR2-AZ8838; Na
5.00	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
5.00	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
5.00	Single	5YC8	N-methyl-Scopolamine	5YC8-M₂-N-methyl-Scopolamine
5.00	Single	5ZK8	N-methyl-Scopolamine	5ZK8-M₂-N-methyl-Scopolamine
5.00	Single	5ZKC	N-methyl-Scopolamine	5ZKC-M₂-N-methyl-Scopolamine
5.00	Single	5ZKP	SR27417	5ZKP-PAF-SR27417
5.00	Single	6DRZ	Methysergide	6DRZ-5-HT_2B-Methysergide
5.00	Single	6FFH	Fenobam	6FFH-mGlu₅-Fenobam
5.00	Single	6GPS	MK0812	6GPS-CCR2-MK0812
5.00	Single	6H7M	Salbutamol	6H7M-β₁-Salbutamol
5.00	Single	6K42	Dexmedetomidine	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
5.00	Single	6PRZ	Alprenolol	6PRZ-β₂-Alprenolol
5.00	Single	6PS1	Timolol	6PS1-β₂-Timolol
5.00	Single	6TOT	Lemborexant	6TOT-OX₁-Lemborexant
5.00	Single	6WHA	DB13948	6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
5.00	Single	7BTS	Epinephrine	7BTS-β₁-Epinephrine
5.00	Single	7BU6	Norepinephrine	7BU6-β₁-Norepinephrine
5.00	Single	7BU7	BI167107	7BU7-β₁-BI167107
5.00	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/β1/γ2
5.00	Single	7E32	Serotonin	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
5.00	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/β1/γ2
5.00	Single	7LJC	SKF81297	7LJC-D₁-SKF81297-Mevidalen-Gs/β1/γ2
5.00	Single	7M3J	NPS-2143; PO4	7M3J-CaS; CaS-NPS-2143; PO4
5.00	Single	7S0G	Isoprenaline	7S0G-β₁-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
5.00	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/β1/γ2
5.00	Single	7UL4	Alvimopan	7UL4-μ-Alvimopan
5.00	Single	7UM5	5-CT	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/β1/γ2
5.00	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/β1/γ2
5.00	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.00	Single	7YAC	Paltusotine	7YAC-SST2-Paltusotine-Gi1/β1/γ2
5.00	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/β1/γ2
5.00	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
5.00	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
5.00	Single	8F0J	Pramlintide Analogue San45	8F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
5.00	Single	8FY8	5-MeO-DMT	8FY8-5-HT_1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1
5.00	Single	8GE2	Constrained Epinephrine	8GE2-β₂-Constrained Epinephrine-Gs/β1/γ1
5.00	Single	8GE3	Constrained Epinephrine	8GE3-β₂-Constrained Epinephrine-Gs/β1/γ2
5.00	Single	8GE9	Constrained Epinephrine	8GE9-β₂-Constrained Epinephrine-Gs/β1/γ2
5.00	Single	8GEC	Constrained Epinephrine	8GEC-β₂-Constrained Epinephrine-Gs/β1/γ2
5.00	Single	8GEE	Constrained Epinephrine	8GEE-β₂-Constrained Epinephrine-Gs/β1/γ2
5.00	Single	8GEH	Constrained Epinephrine	8GEH-β₂-Constrained Epinephrine-Gs/β1/γ2
5.00	Single	8GFV	Constrained Epinephrine	8GFV-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8GFW	Constrained Epinephrine	8GFW-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8GFX	Constrained Epinephrine	8GFX-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8GFZ	Constrained Epinephrine	8GFZ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8GG0	Constrained Epinephrine	8GG0-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8GG1	Constrained Epinephrine	8GG1-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8GG3	Constrained Epinephrine	8GG3-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8GG4	Constrained Epinephrine	8GG4-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8GG6	Constrained Epinephrine	8GG6-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8GG9	Constrained Epinephrine	8GG9-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8GGI	Constrained Epinephrine	8GGI-β₂-Constrained Epinephrine
5.00	Single	8GGJ	Constrained Epinephrine	8GGJ-β₂-Constrained Epinephrine
5.00	Single	8GGK	Constrained Epinephrine	8GGK-β₂-Constrained Epinephrine
5.00	Single	8GGN	Constrained Epinephrine	8GGN-β₂-Constrained Epinephrine
5.00	Single	8GGO	Constrained Epinephrine	8GGO-β₂-Constrained Epinephrine
5.00	Single	8GGU	Constrained Epinephrine	8GGU-β₂-Constrained Epinephrine
5.00	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/β1/γ2
5.00	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/β1/γ2
5.00	Single	8IRT	Rotigotine	8IRT-D₃-Rotigotine-Gi1/β1/γ2
5.00	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-PubChem 25101223-Gi1/β1/γ2
5.00	Single	8JHN	Monomethyl fumarate	8JHN-HCA₂-Monomethyl fumarate-Go/β1/γ2
5.00	Single	8JII	Niacin	8JII-HCA₂-Niacin-PubChem 25101223-Gi1/β1/γ2
5.00	Single	8JJO	Alprenolol	8JJO-β₂-Alprenolol
5.00	Single	8JLJ	T1AM	8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
5.00	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/β1/γ2
5.00	Single	8JXR	LSD	8JXR-D₁-LSD
5.00	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
5.00	Single	8KFY	ZK-756326	8KFY-CCR8-ZK-756326-Gi1/β1/γ2
5.00	Single	8PJK	ST171	8PJK-5-HT_1A-ST171-Gi1/β1/γ1
5.00	Single	8T1W	CVN424	8T1W-GPR6-CVN424
5.00	Single	8UGY	Mianserin	8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1
5.00	Single	8UNQ	Constrained Epinephrine	8UNQ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8UNR	Constrained Epinephrine	8UNR-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8UNU	Constrained Epinephrine	8UNU-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8UNV	Constrained Epinephrine	8UNV-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8UNY	Constrained Epinephrine	8UNY-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8UNZ	Constrained Epinephrine	8UNZ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8UO2	Constrained Epinephrine	8UO2-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
5.00	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
5.00	Single	8WC7	ZH8667	8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
5.00	Single	8X17	Namodenoson	8X17-A_3A-Namodenoson-Gi1/β1/γ2
5.00	Single	8X64	Desloratadine	8X64-H₁-Desloratadine
5.00	Single	8XVK	Ambrisentan	8XVK-ET_A-Ambrisentan
5.00	Single	8Y71	A1D6F	8Y71-δ-A1D6F-BMS986187-Gi1/β1/γ2
5.00	Single	8YH5	Riboprine	8YH5-A_3A-Riboprine-Gi1/β1/γ2
5.00	Single	8YN8	Proxyfan	8YN8-H₃-Proxyfan-Go/β1/γ2
5.00	Single	8ZQE	GPR15L(CT)	8ZQE-GPR15-GPR15L(CT)-Gi1/β1/γ1
5.00	Single	8ZSS	RO5263397	8ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
5.00	Single	9CBM	Dexmedetomidine	9CBM-α_2a-Dexmedetomidine-Gi1/β1/γ2
5.00	Single	9D61	JDTic	9D61-κ-JDTic-Gi1/β1/γ2
5.00	Single	9DYF	Asenapine	9DYF-5-HT_1A-Asenapine-PtdIns4P-Gi1/β1/γ2
5.00	Single	9IZC	MK1903	9IZC-HCA₂-MK1903-Gi1/β1/γ2
5.00	Single	9JEA	Atropine	9JEA-M₁-Atropine
5.00	Single	9KFJ	PubChem 138319674	9KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
5.00	Single	9KUX	CMPD644	9KUX-Apelin; Apelin-CMPD644-Arrestin2
5.00	Single	9PLN	PubChem 168259594	9PLN-α_2a-PubChem 168259594
5.00	Single	9PLO	PubChem 168259594	9PLO-α_2a-PubChem 168259594-Go/β1/γ2
5.00	Single	9PQD	PubChem 176491927	9PQD-α_2a-PubChem 176491927
5.00	Single	9PXW	Naloxone	9PXW-μ-Naloxone-GDPβS-Gi1/β1/γ2
5.00	Single	9UAZ	Atropine	9UAZ-M₁-Atropine
5.00	Single	9VMY	TMU4142	9VMY-5-HT_1A-TMU4142-Go/β1/γ2
5.00	Consensus	5ht1d_on	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
5.00	Consensus	5ht1d_on_gp	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
5.00	Consensus	5ht2b_off	Orthosteric Ligand	6DRZ-5-HT_2B-Methysergide
5.00	Consensus	a3_on	Orthosteric Ligand	a3a_on
5.00	Consensus	adenosine_on_gp	Orthosteric Ligand	a1_on_gp a2_on_gp a3_on_gp
5.00	Consensus	adrenergic_on	Orthosteric Ligand	alpha_on beta_on
5.00	Consensus	alpha2_on	Orthosteric Ligand	alpha2b_on
5.00	Consensus	alpha2_on_gp	Orthosteric Ligand	alpha2b_on_gp
5.00	Consensus	alpha2b_on	Orthosteric Ligand	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
5.00	Consensus	alpha2b_on_gp	Orthosteric Ligand	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
5.00	Consensus	alpha_on	Orthosteric Ligand	alpha1_on alpha2_on
5.00	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
5.00	Consensus	blt1_on_gp	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
5.00	Consensus	blt_on	Orthosteric Ligand	blt1_on
5.00	Consensus	blt_on_gp	Orthosteric Ligand	blt1_on_gp
5.00	Consensus	ccr2_off	Orthosteric Ligand	6GPS-CCR2-MK0812
5.00	Consensus	d5_on	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
5.00	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
5.00	Consensus	dopamine_off	Orthosteric Ligand	d2_off d3_off
5.00	Consensus	dopamine_on	Orthosteric Ligand	d2_on d1_on d3_on d4_on d5_on
5.00	Consensus	dopamine_on_gp	Orthosteric Ligand	d2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
5.00	Consensus	gi_hca	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-Monomethyl fumarate-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
5.00	Consensus	gi_histamine	Orthosteric Ligand	8JXX-H₄-Clobenpropit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8YUU-H₃-Histamine-Gi1/β1/γ1 8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2
5.00	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
5.00	Consensus	gq_amine	Orthosteric Ligand	gq_muscarinic gq_histamine
5.00	Consensus	gs_trace-amine	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
5.00	Consensus	hca2_on	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-Monomethyl fumarate-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2
5.00	Consensus	hca2_on_gp	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8JIM-HCA₂-Monomethyl fumarate-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
5.00	Consensus	hca_on_gp	Orthosteric Ligand	hca2_on_gp
5.00	Consensus	leukotriene_on	Orthosteric Ligand	blt_on
5.00	Consensus	leukotriene_on_gp	Orthosteric Ligand	blt_on_gp
5.00	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
5.00	Consensus	m4_off	Orthosteric Ligand	5DSG-M₄-Tiotropium
5.00	Consensus	muscarinic_on	Orthosteric Ligand	m2_on m3_on m4_on m1_on
5.00	Consensus	muscarinic_on_gp	Orthosteric Ligand	m2_on_gp m3_on_gp m4_on_gp m1_on_gp
4.88	Consensus	pth_on_gp	Orthosteric Ligand	pth1_on_gp pth2_on_gp
4.76	Single	2RH1	Carazolol	2RH1-β₂-Carazolol
4.76	Single	2Y03	Isoprenaline	2Y03-β₁-Isoprenaline
4.76	Single	2YCW	Carazolol	2YCW-β₁-Carazolol
4.76	Single	4ZJ8	Suvorexant	4ZJ8-OX₁-Suvorexant
4.76	Single	5C1M	BU72	5C1M-μ-BU72
4.76	Single	5CGC	HTL14242	5CGC-mGlu₅-HTL14242
4.76	Single	5D6L	Carazolol	5D6L-β₂-Carazolol
4.76	Single	5JQH	Carazolol	5JQH-β₂-Carazolol
4.76	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
4.76	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
4.76	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
4.76	Single	5WQC	EMPA	5WQC-OX₂-EMPA
4.76	Single	5X7D	Carazolol	5X7D-β₂-Carazolol-PubChem 129318963
4.76	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/β1/γ1
4.76	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
4.76	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
4.76	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
4.76	Single	6OIK	Iperoxo	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
4.76	Single	6PS3	Carvedilol	6PS3-β₂-Carvedilol
4.76	Single	6PS6	Timolol	6PS6-β₂-Timolol
4.76	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
4.76	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
4.76	Single	7BVQ	Carazolol	7BVQ-β₁-Carazolol
4.76	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
4.76	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-MIPS521-Gi2/β1/γ2
4.76	Single	7M3J	NPS-2143; PO4	7M3J-CaS; CaS-NPS-2143; PO4
4.76	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/β1/γ2
4.76	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/β1/γ2
4.76	Single	7SIN	NPS-2143	7SIN-CaS; CaS-NPS-2143
4.76	Single	7SIN	NPS-2143	7SIN-CaS; CaS-NPS-2143
4.76	Single	7WC6	LSD	7WC6-5-HT_2A-LSD
4.76	Single	7WIG	L-054264	7WIG-SST2-L-054264-Gi1/β1/γ2
4.76	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76	Single	7XK9	Constrained Isoproterenol	7XK9-β₂-Constrained Isoproterenol-Na
4.76	Single	7XKA	Constrained Epinephrine	7XKA-β₂-Constrained Epinephrine
4.76	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/β1/γ2
4.76	Single	8DZR	GR89,696	8DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
4.76	Single	8E9Z	Iperoxo	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76	Single	8EFB	Oliceridine	8EFB-μ-Oliceridine-Gi1/β1/γ2
4.76	Single	8GDZ	Constrained Epinephrine	8GDZ-β₂-Constrained Epinephrine-Gs/β1/γ2
4.76	Single	8GEB	Constrained Epinephrine	8GEB-β₂-Constrained Epinephrine-Gs/β1/γ2
4.76	Single	8GEG	Constrained Epinephrine	8GEG-β₂-Constrained Epinephrine-Gs/β1/γ2
4.76	Single	8GFY	Constrained Epinephrine	8GFY-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8GG2	Constrained Epinephrine	8GG2-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8GGB	Constrained Epinephrine	8GGB-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/β1/γ2
4.76	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/β1/γ2
4.76	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/β1/γ2
4.76	Single	8S4D	CMF-019	8S4D-Apelin-CMF-019
4.76	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
4.76	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
4.76	Single	8UNN	Constrained Epinephrine	8UNN-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8UNP	Constrained Epinephrine	8UNP-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76	Single	8UUJ	FCH-2296413	8UUJ-HCA₂-FCH-2296413-Gi1/β1/γ2
4.76	Single	8X0B	VU0424465	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.76	Single	8X0C	VU0424465	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.76	Single	8X0C	VU0424465	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.76	Single	8X0D	VU0424465	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.76	Single	8X0D	VU0424465	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.76	Single	8YH0	NECA	8YH0-A_3A-NECA-Gi1/β1/γ2
4.76	Single	8ZMF	PubChem 171920673	8ZMF-5-HT_2C-PubChem 171920673
4.76	Single	9ARZ	2-bromo-LSD	9ARZ-5-HT_2A-2-bromo-LSD
4.76	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
4.76	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
4.76	Single	9CIB	FCH-2296413	9CIB-HCA₂-FCH-2296413
4.76	Single	9DYD	Asenapine	9DYD-5-HT_1A-Asenapine-PtdIns4P-Go/β1/γ2
4.76	Single	9EE8	Adenosine	9EE8-A_2A-Adenosine-Gs/β1/γ2
4.76	Single	9F33	FOB02-04A	9F33-D₃-FOB02-04A-Go/β1/γ2
4.76	Single	9F34	FOB02-04A	9F34-D₃-FOB02-04A-Go/β1/γ2
4.76	Single	9HAP	Tolvaptan	9HAP-V₂-Tolvaptan
4.76	Single	9HC0	4YI	9HC0-mGlu₅-4YI
4.76	Single	9KT6	Acifran	9KT6-HCA₃-Acifran-Gi1/β1/γ2
4.76	Single	9KUT	JR14a	9KUT-C3a_B-JR14a-Go/β1/γ2
4.76	Single	9KUV	CMPD644	9KUV-Apelin-CMPD644-Arrestin2
4.76	Single	9MQK	Isoquinuclidine	9MQK-κ-Isoquinuclidine
4.76	Single	9PXY	Naloxone	9PXY-μ-Naloxone-GDPβS-Gi1/β1/γ2
4.76	Single	9VJF	Buspirone	9VJF-5-HT_1A-Buspirone-Gi3/β1/γ2
4.76	Consensus	5ht1_on	Orthosteric Ligand	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
4.76	Consensus	5ht1_on_gp	Orthosteric Ligand	5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
4.76	Consensus	5ht1e_on_gp	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
4.76	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
4.76	Consensus	5ht5_on_gp	Orthosteric Ligand	5ht5a_on_gp
4.76	Consensus	5ht5a_on_gp	Orthosteric Ligand	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
4.76	Consensus	a3_on_gp	Orthosteric Ligand	a3a_on_gp
4.76	Consensus	a3a_on	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
4.76	Consensus	a3a_on_gp	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
4.76	Consensus	adgrg2_on	Orthosteric Ligand	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
4.76	Consensus	adgrg2_on_gp	Orthosteric Ligand	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
4.76	Consensus	adrenergic_off	Orthosteric Ligand	alpha_off beta_off
4.76	Consensus	adrenergic_on_gp	Orthosteric Ligand	alpha_on_gp beta_on_gp
4.76	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
4.76	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
4.76	Consensus	alpha_on_gp	Orthosteric Ligand	alpha1_on_gp alpha2_on_gp
4.76	Consensus	amine_off	Orthosteric Ligand	5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
4.76	Consensus	amine_offon	Orthosteric Ligand	amine_off amine_on
4.76	Consensus	amine_offon_gp	Orthosteric Ligand	amine_on_gp amine_off
4.76	Consensus	amine_on	Orthosteric Ligand	5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
4.76	Consensus	beta2_off	Orthosteric Ligand	2RH1-β₂-Carazolol 6PS3-β₂-Carvedilol 6PS5-β₂-Propranolol 3D4S-β₂-Timolol 3NY8-β₂-ICI118-551 3NY9-β₂-PubChem 913103 6PRZ-β₂-Alprenolol
4.76	Consensus	beta_off	Orthosteric Ligand	beta1_off beta2_off
4.76	Consensus	blt1_off	Orthosteric Ligand	5X33-BLT₁-BIIL260 7K15-BLT₁-MKD046-Na
4.76	Consensus	blt_off	Orthosteric Ligand	blt1_off
4.76	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
4.76	Consensus	d4_on	Orthosteric Ligand	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.76	Consensus	gi_adrenergic	Orthosteric Ligand	7EJ0-α_2a-Norepinephrine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
4.76	Consensus	gq_muscarinic	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.76	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
4.76	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
4.76	Consensus	lipid_on_gp	Orthosteric Ligand	cannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
4.76	Consensus	m1_on	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.76	Consensus	m2_off	Orthosteric Ligand	5ZKC-M₂-N-methyl-Scopolamine 5ZK3-M₂-3-quinuclidinyl-benzilate 5ZKB-M₂-AF-DX 384
4.76	Consensus	m3_on	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76	Consensus	m3_on_gp	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
4.76	Consensus	rxfp4_on_gp	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
4.76	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs)/β1/γ2
4.76	Consensus	trace-amine_on	Orthosteric Ligand	ta1_on
4.55	Single	2YDV	NECA	2YDV-A_2A-NECA
4.55	Single	3PDS	FAUC50	3PDS-β₂-FAUC50
4.55	Single	4DJH	JDTic	4DJH-κ-JDTic
4.55	Single	4LDL	Hydroxybenzyl Isoproterenol	4LDL-β₂-Hydroxybenzyl Isoproterenol
4.55	Single	4OO9	Mavoglurant	4OO9-mGlu₅-Mavoglurant
4.55	Single	4U15	Tiotropium	4U15-M₃-Tiotropium
4.55	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
4.55	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
4.55	Single	5D5A	Carazolol	5D5A-β₂-Carazolol
4.55	Single	5D5B	Carazolol	5D5B-β₂-Carazolol
4.55	Single	5G53	NECA	5G53-A_2A-NECA-Gs
4.55	Single	5V54	Methiothepin	5V54-5-HT_1B-Methiothepin
4.55	Single	5ZKB	AF-DX 384	5ZKB-M₂-AF-DX 384
4.55	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
4.55	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
4.55	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
4.55	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
4.55	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
4.55	Single	6OIJ	Iperoxo	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.55	Single	6OL9	Tiotropium	6OL9-M₅-Tiotropium
4.55	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
4.55	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2
4.55	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/β1/γ2
4.55	Single	7P2L	4YI	7P2L-mGlu₅-4YI
4.55	Single	7R0C	AVP	7R0C-V₂-AVP-Arrestin2
4.55	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/β1/γ2
4.55	Single	7TRQ	Iperoxo	7TRQ-M₄-Iperoxo-VU0467154-Gi1/β1/γ2
4.55	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
4.55	Single	7U2L	C5-guano	7U2L-μ-C5-guano-Gi1/β1/γ2
4.55	Single	7W6P	N-pyridin-4-ylisoquinolin-4-amine	7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
4.55	Single	7W7E	PubChem 164946676	7W7E-α_2a-PubChem 164946676-Go/β1/γ2
4.55	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/β1/γ2
4.55	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/β1/γ2
4.55	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2
4.55	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/β1/γ2
4.55	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/β1/γ2
4.55	Single	8EA0	Iperoxo	8EA0-M₃-Iperoxo
4.55	Single	8EF5	Fentanyl	8EF5-μ-Fentanyl-Gi1/β1/γ2
4.55	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/β1/γ2
4.55	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/β1/γ2
4.55	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/β1/γ2
4.55	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/β1/γ2
4.55	Single	8IRU	Rotigotine	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.55	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
4.55	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/β1/γ2
4.55	Single	8JBG	Neurokinin-B	8JBG-NK₃-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2
4.55	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/β1/γ2
4.55	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/β1/γ2
4.55	Single	8JXX	Clobenpropit	8JXX-H₄-Clobenpropit-Gi1/β1/γ2
4.55	Single	8T1V	PubChem 118310209	8T1V-GPR6-PubChem 118310209-Na
4.55	Single	8TAO	CDPPB	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.55	Single	8UGW	CGS21680	8UGW-A_2A-CGS21680
4.55	Single	8VVE	norBNI	8VVE-κ-norBNI-Gi1/β1/γ2
4.55	Single	8VVF	JDTic	8VVF-κ-JDTic-Gi1/β1/γ2
4.55	Single	8X0B	VU0424465	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.55	Single	8X0F	VU29	8X0F-mGlu5; mGlu5-Quisqualate-VU29
4.55	Single	8X16	Piclidenoson	8X16-A_3A-Piclidenoson-Gi1/β1/γ2
4.55	Single	8XIP	Pasireotide	8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.55	Single	8XQT	Cholesterol	8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
4.55	Single	8XVL	Zibotentan	8XVL-ET_A-Zibotentan
4.55	Single	8YH6	Namodenoson	8YH6-A_3A-Namodenoson-Gi1/β1/γ2
4.55	Single	9AS9	RS130-180	9AS9-5-HT_2A-RS130-180
4.55	Single	9ASA	RS130-180	9ASA-5-HT_2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
4.55	Single	9B65	MDMB-Fubinaca	9B65-CB₁-MDMB-Fubinaca-Gi1/β1/γ2
4.55	Single	9BJK	Naloxone	9BJK-μ-Naloxone-PubChem 171642066
4.55	Single	9BS9	LSD	9BS9-D₂-LSD
4.55	Single	9BSB	LSD	9BSB-D₂-LSD-chim(NtGi1-Go)/β1/γ2
4.55	Single	9IJD	Carazolol	9IJD-β₃-Carazolol-chim(NtGi1-Gs)/β1/γ2
4.55	Single	9IK9	Lanreotide	9IK9-SST1-Lanreotide-Gi1/β1/γ2
4.55	Single	9PY3	Loperamide	9PY3-μ-Loperamide-GDPβS-Gi1/β1/γ2
4.55	Single	9PY4	Loperamide	9PY4-μ-Loperamide-GDPβS-Gi1/β1/γ2
4.55	Single	9UCP	Iperoxo	9UCP-M₁-Iperoxo-G11(CT)
4.55	Consensus	5ht1_off	Orthosteric Ligand	5ht1b_off
4.55	Consensus	5ht1b_off	Orthosteric Ligand	5V54-5-HT_1B-Methiothepin
4.55	Consensus	5ht_off	Orthosteric Ligand	5ht2_off 5ht1_off
4.55	Consensus	a2_on	Orthosteric Ligand	a2b_on
4.55	Consensus	a2_on_gp	Orthosteric Ligand	a2b_on_gp
4.55	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
4.55	Consensus	a2b_on_gp	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
4.55	Consensus	amine_on_gp	Orthosteric Ligand	5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
4.55	Consensus	beta1_off	Orthosteric Ligand	2VT4-β₁-Cyanopindolol 2YCW-β₁-Carazolol 2YCZ-β₁-Iodocyanopindolol 5A8E-β₁-7-Methylcyanopindolol-Na 3ZPQ-β₁-PubChem 594590-Na 3ZPR-β₁-PubChem 598754-Na
4.55	Consensus	beta2_on	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
4.55	Consensus	beta2_on_gp	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
4.55	Consensus	class-a_off	Orthosteric Ligand	sensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
4.55	Consensus	d1_on_gp	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
4.55	Consensus	d4_on_gp	Orthosteric Ligand	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.55	Consensus	d5_on_gp	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
4.55	Consensus	gi_5ht	Orthosteric Ligand	8FYT-5-HT_1A-LSD-PtdIns4P-Gi1/β1/γ1 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT_1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT_1A-Serotonin-PtdIns4P-Gi1/β1/γ2 7E32-5-HT_1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT₄-Serotonin-Gi1/β1/γ2 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT_1A-Vilazodone-PtdIns4P-Gi1/β1/γ1 8JT6-5-HT_1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2 8FYE-5-HT_1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1 7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1 7E2Z-5-HT_1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2 7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT_1A-Buspirone-PtdIns4P-Gi1/β1/γ1 7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2
4.55	Consensus	gi_dopamine	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 7CMV-D₃-PD128907-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2
4.55	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
4.55	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
4.55	Consensus	gs_adrenergic	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2 7JJO-β₁-Isoprenaline-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2 8DCR-β₁-Dobutamine-Gs/β1/γ2 7XJH-β₃-Isoprenaline-Gs/β1/γ2 7DH5-β₃-Mirabegron-Gs/β1/γ2
4.55	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2
4.55	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
4.55	Consensus	h4_on_gp	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2 8JXX-H₄-Clobenpropit-Gi1/β1/γ2
4.55	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
4.55	Consensus	m1_on_gp	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.55	Consensus	m5_off	Orthosteric Ligand	6OL9-M₅-Tiotropium
4.55	Consensus	muscarinic_off	Orthosteric Ligand	m2_off m3_off m4_off m5_off m1_off
4.55	Consensus	protein_off	Orthosteric Ligand	chemokine_off grh_off
4.55	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
4.55	Consensus	relaxin_on_gp	Orthosteric Ligand	rxfp4_on_gp
4.55	Consensus	ta1_on_gp	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs)/β1/γ2
4.55	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
4.55	Consensus	trace-amine_on_gp	Orthosteric Ligand	ta1_on_gp
4.35	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
4.35	Single	3D4S	Timolol	3D4S-β₂-Timolol
4.35	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
4.35	Single	4LDE	BI167107	4LDE-β₂-BI167107
4.35	Single	4PXF	Octyl-Beta-D-Glucopyranoside	4PXF-Rhodopsin-Octyl-β-D-Glucopyranoside-Arrestin1 Finger Loop
4.35	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
4.35	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
4.35	Single	5CXV	Tiotropium	5CXV-M₁-Tiotropium
4.35	Single	5X33	BIIL260	5X33-BLT₁-BIIL260
4.35	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
4.35	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
4.35	Single	6DRY	Methylergometrine	6DRY-5-HT_2B-Methylergometrine
4.35	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
4.35	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/β1/γ2
4.35	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
4.35	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/β1/γ2
4.35	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
4.35	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
4.35	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/β1/γ2
4.35	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
4.35	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
4.35	Single	7W0L	PubChem 122701908	7W0L-Apelin; Apelin-PubChem 122701908-Gi1/β1/γ2
4.35	Single	7W0N	Elabela	7W0N-Apelin; Apelin-Elabela-Gi1/β1/γ2
4.35	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/β1/γ2
4.35	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.35	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
4.35	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
4.35	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35	Single	8FYE	4-F,5-MeO-PyrT	8FYE-5-HT_1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1
4.35	Single	8FYT	LSD	8FYT-5-HT_1A-LSD-PtdIns4P-Gi1/β1/γ1
4.35	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/β1/γ2
4.35	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/β1/γ2
4.35	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/β1/γ2
4.35	Single	8JJ8	Arformoterol	8JJ8-β₂-Arformoterol
4.35	Single	8JJP	Chemerin-9	8JJP-CML2-Chemerin-9-Gi1/β1/γ2
4.35	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/β1/γ2
4.35	Single	8XQN	Cholesterol	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.35	Single	8XQS	Cholesterol	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
4.35	Single	9EBI	Piclidenoson	9EBI-A_3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
4.35	Single	9EK0	Iperoxo	9EK0-M₅-Iperoxo-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	9GL2	Befiradol	9GL2-5-HT_1A-Befiradol-Gs/β1/γ2
4.35	Single	9KVG	5-MeO-DMT	9KVG-5-HT_1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ2
4.35	Single	9M8P	Oleic monoethanolamide	9M8P-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
4.35	Single	9V6O	Nalfurafine	9V6O-κ-Nalfurafine-Gi1/β1/γ2
4.35	Single	9VJ6	F-15599	9VJ6-5-HT_1A-F-15599-Gi3/β1/γ2
4.35	Single	9W32	SSTR5 antagonist 1	9W32-SST5-SSTR5 antagonist 1
4.35	Single	9WSW	Endomorphin	9WSW-μ-Endomorphin-chim(NtGi1-Gz)/β1/γ2
4.35	Consensus	5ht1a_on	Orthosteric Ligand	8FYT-5-HT_1A-LSD-PtdIns4P-Gi1/β1/γ1 7E2Y-5-HT_1A-Serotonin-PtdIns4P-Gi1/β1/γ2 7E2Z-5-HT_1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2 8FYX-5-HT_1A-Buspirone-PtdIns4P-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT_1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1 8FYE-5-HT_1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1 8FYL-5-HT_1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
4.35	Consensus	5ht1a_on_gp	Orthosteric Ligand	8FYT-5-HT_1A-LSD-PtdIns4P-Gi1/β1/γ1 8FYX-5-HT_1A-Buspirone-PtdIns4P-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT_1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2 7E2Y-5-HT_1A-Serotonin-PtdIns4P-Gi1/β1/γ2 7E2Z-5-HT_1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1 8FYE-5-HT_1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1 8FYL-5-HT_1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
4.35	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
4.35	Consensus	5ht1f_on_gp	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
4.35	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off
4.35	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin
4.35	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoprenaline-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
4.35	Consensus	beta3_on_gp	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoprenaline-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
4.35	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
4.35	Consensus	beta_on_gp	Orthosteric Ligand	beta1_on_gp beta2_on_gp beta3_on_gp
4.35	Consensus	d2_on_gp	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
4.35	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
4.35	Consensus	gi_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
4.35	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
4.35	Consensus	leukotriene_off	Orthosteric Ligand	blt_off cyslt_off
4.35	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
4.35	Consensus	m1_off	Orthosteric Ligand	5CXV-M₁-Tiotropium
4.35	Consensus	mop_on	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
4.35	Consensus	mop_on_gp	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
4.35	Consensus	nk1_off	Orthosteric Ligand	6HLP-NK₁-Netupitant 6HLO-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
4.35	Consensus	opioid_off	Orthosteric Ligand	mop_off nop_off dop_off kop_off
4.35	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.35	Consensus	trh_on_gp	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.17	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
4.17	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
4.17	Single	5CGD	HTL14242	5CGD-mGlu₅-HTL14242
4.17	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
4.17	Single	5X93	K-8794	5X93-ET_B-K-8794
4.17	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
4.17	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
4.17	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
4.17	Single	7EZC	UK-432097	7EZC-A_2A-UK-432097
4.17	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2
4.17	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/β1/γ2
4.17	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
4.17	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/β1/γ2
4.17	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/β1/γ2
4.17	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/β1/γ2
4.17	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/β1/γ2
4.17	Single	7Y27	Somatostatin-14	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17	Single	8E0G	BU72	8E0G-μ-BU72
4.17	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
4.17	Single	8E9Y	Clozapine-N-oxide	8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
4.17	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/β1/γ2
4.17	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/β1/γ2
4.17	Single	8J19	LY237	8J19-GPR84-LY237-Gi1/β1/γ2
4.17	Single	8S2T	Isoprenaline	8S2T-β₁-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
4.17	Single	8XGS	Kisspeptin-1	8XGS-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ2
4.17	Single	8XIO	L797591	8XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.17	Single	8XVJ	Macitentan	8XVJ-ET_A-Macitentan
4.17	Single	8ZWG	JR14a	8ZWG-C3a_B-JR14a-Gi1/β1/γ2
4.17	Single	9AS0	2-bromo-LSD	9AS0-5-HT_2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	9C0K	Exendin-4	9C0K-GLP-1-Exendin-4-Gs/β1/γ2
4.17	Single	9CGJ	C6-Quino	9CGJ-δ-C6-Quino-Gi1/β1/γ2
4.17	Single	9DYE	Buspirone	9DYE-5-HT_1A-Buspirone-PtdIns4P-Go/β1/γ2
4.17	Single	9KT8	Acifran	9KT8-HCA₂-Acifran-Gi1/β1/γ2
4.17	Single	9KUG	EP67	9KUG-C5a₁-EP67-Go/β1/γ2
4.17	Single	9M54	Neuropeptide-VF	9M54-NPFF2-Neuropeptide-VF-Gi1/β1/γ2
4.17	Single	9UYH	Chemerin-9	9UYH-CML2-Chemerin-9-Arrestin2
4.17	Single	9UYM	Chemerin-9	9UYM-CML2-Chemerin-9-chim(Arrestin3-CtArrestin2)
4.17	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
4.17	Consensus	class-a_on	Orthosteric Ligand	sensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
4.17	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
4.17	Consensus	endothelin_off	Orthosteric Ligand	etb_off
4.17	Consensus	etb_off	Orthosteric Ligand	5X93-ET_B-K-8794 5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500
4.17	Consensus	kop_on_gp	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
4.17	Consensus	nucleotide_on_gp	Orthosteric Ligand	adenosine_on_gp p2y_on_gp
4.00	Single	3NY9	PubChem 913103	3NY9-β₂-PubChem 913103
4.00	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
4.00	Single	5VBL	AMG3054	5VBL-Apelin-AMG3054
4.00	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
4.00	Single	6PT3	DPI-287	6PT3-δ-DPI-287
4.00	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
4.00	Single	7RKF	CX3CL1	7RKF-US28-CX3CL1-GDP-chim(NtGi1-G11)/β1/γ2
4.00	Single	7RKN	CX3CL1	7RKN-US28-CX3CL1-Gi1/β1/γ2
4.00	Single	7T11	Octreotide	7T11-SST2-Octreotide-Gi3/β1/γ2
4.00	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/β1/γ2
4.00	Single	7XN9	L-054522	7XN9-SST2-L-054522
4.00	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/β1/γ2
4.00	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/β1/γ2
4.00	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/β1/γ2
4.00	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
4.00	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
4.00	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
4.00	Single	8XQL	Cholesterol	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.00	Single	8XZF	WN561	8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2
4.00	Single	9CGK	C5-Quino	9CGK-δ-C5-Quino-Gi1/β1/γ2
4.00	Single	9EAJ	Nanobody AT209	9EAJ-AT₁-Nanobody AT209
4.00	Single	9IPV	JR14a	9IPV-C3a_B-JR14a-Gi1/β1/γ2
4.00	Single	9IPY	JR14a	9IPY-C3a_B-JR14a
4.00	Single	9IZA	SCH900271	9IZA-HCA₂-SCH900271-Gi1/β1/γ2
4.00	Single	9M0R	Neuropeptide-VF	9M0R-NPFF1-Neuropeptide-VF-Gi1/β1/γ2
4.00	Single	9MD1	Buspirone	9MD1-5-HT_1A-Buspirone-PtdIns4P-Gz/β1/γ2
4.00	Single	9WSX	Endomorphin	9WSX-μ-Endomorphin-Arrestin2
4.00	Consensus	cxcr_on_gp	Orthosteric Ligand	cxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
4.00	Consensus	nmur1_on	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Consensus	sst2_on	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
4.00	Consensus	sst2_on_gp	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
3.85	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
3.85	Single	4XT1	CX3CL1	4XT1-US28-CX3CL1
3.85	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
3.85	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
3.85	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
3.85	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/β1/γ2
3.85	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2
3.85	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
3.85	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/β1/γ2
3.85	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/β1/γ2
3.85	Single	8IEP	PubChem 134746894	8IEP-GPR156; GPR156-PubChem 134746894
3.85	Single	8INR	Alpha-MSH	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
3.85	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/β1/γ2
3.85	Single	8K3Z	CXCL12	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
3.85	Single	8PKM	Befiradol	8PKM-5-HT_1A-Befiradol-Gi1/β1/γ1
3.85	Single	8WDT	photoNECA	8WDT-A_2A-photoNECA
3.85	Single	8ZBJ	Somatostatin-14	8ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
3.85	Single	8ZSP	LSD	8ZSP-TA1-LSD-chim(NtGi1L-Gs)/β1/γ2
3.85	Single	9BUE	Cagrilintide	9BUE-CT-Cagrilintide-Gs/β1/γ2
3.85	Single	9BUY	LM189	9BUY-β₂-LM189-Gi1/β1/γ2
3.85	Single	9L3Y	Chemerin	9L3Y-CML2-Chemerin-Gi1/β1/γ2
3.85	Consensus	class-a_on_gp	Orthosteric Ligand	sensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
3.85	Consensus	gi_nucleotide	Orthosteric Ligand	gi_adenosine gi_p2y
3.85	Consensus	gi_opioid	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
3.85	Consensus	mc4_on	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
3.85	Consensus	mop_off	Orthosteric Ligand	4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
3.85	Consensus	nk3_on	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85	Consensus	nk3_on_gp	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85	Consensus	nmur1_on_gp	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85	Consensus	sst5_on	Orthosteric Ligand	8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
3.70	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
3.70	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
3.70	Single	6DO1	(Sar1,Ile8)-Angiotensin II	6DO1-AT₁-(Sar1,Ile8)-Angiotensin II
3.70	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
3.70	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
3.70	Single	7VBI	Tirzepatide (non-acylated)	7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
3.70	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
3.70	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2
3.70	Single	8F7Q	Beta-Endorphin	8F7Q-μ-β-Endorphin-Gi1/β1/γ2
3.70	Single	8JZZ	C5a-des-Arg	8JZZ-C5a₁-C5a-des-Arg-Go/β1/γ2
3.70	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
3.70	Single	8Z7J	JN241-9	8Z7J-Apelin-JN241-9-Gi1/β1/γ2
3.70	Single	9IK8	Pasireotide	9IK8-SST1-Pasireotide-Gi1/β1/γ2
3.70	Single	9IQV	Muscarinic toxin 3	9IQV-Alpha1A-Muscarinic toxin 3
3.70	Single	9JFK	(Pen5)-Urotensin II	9JFK-UT-(Pen5)-Urotensin II-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.70	Single	9KFI	Relaxin-3	9KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
3.70	Single	9KT7	MK6892	9KT7-HCA₂-MK6892-Gi1/β1/γ2
3.70	Single	9UMX	EP54	9UMX-C5a₁-EP54-Go/β1/γ2
3.70	Consensus	ccr8_on_gp	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
3.70	Consensus	gq_class-a	Orthosteric Ligand	gq_peptide gq_amine gq_nucleotide
3.70	Consensus	sst4_on	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
3.70	Consensus	sst4_on_gp	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
3.70	Consensus	tachykinin_on_gp	Orthosteric Ligand	nk1_on_gp nk2_on_gp nk3_on_gp
3.57	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
3.57	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
3.57	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
3.57	Single	6VN7	PACAP27	6VN7-VPAC₁-PACAP27-Gs/β1/γ2
3.57	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
3.57	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/β1/γ2
3.57	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/β1/γ2
3.57	Single	8XGU	TAK448	8XGU-Kiss1-TAK448-Gi1/β1/γ2
3.57	Single	8XIQ	L796778	8XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
3.57	Single	8XZH	MM07	8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2
3.57	Single	9B54	VIP36	9B54-CB₁-VIP36-Gi1/β1/γ2
3.57	Single	9LXR	LA-PTH Analog	9LXR-PTH1-LA-PTH Analog-Arrestin2
3.57	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
3.57	Consensus	ccr2_on_gp	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
3.57	Consensus	class-b1_class-b2_cons_on	Orthosteric Ligand	class-b1_on class-b2_on
3.57	Consensus	class-b1_class-b2_cons_on_gp	Orthosteric Ligand	class-b1_on_gp class-b2_on_gp
3.57	Consensus	gi_somatostatin	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
3.57	Consensus	somatostatin_on	Orthosteric Ligand	sst2_on sst4_on sst5_on
3.57	Consensus	somatostatin_on_gp	Orthosteric Ligand	sst2_on_gp sst4_on_gp sst5_on_gp
3.45	Single	6M1I	PACAP27	6M1I-PAC₁-PACAP27-Gs/β1/γ2
3.45	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
3.45	Single	7F6G	(Sar1)-Angiotensin II	7F6G-AT₁-(Sar1)-Angiotensin II-Gq/β1/γ2
3.45	Single	7KH0	AVP	7KH0-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
3.45	Single	7T10	Somatostatin-14	7T10-SST2-Somatostatin-14-Gi3/β1/γ2
3.45	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
3.45	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
3.45	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/β1/γ2
3.45	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/β1/γ2
3.45	Single	8WST	MCH	8WST-MCH2-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.45	Single	8X8L	Cortistatin-14	8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2
3.45	Single	8ZBI	Somatostatin-14	8ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
3.45	Single	9BKK	Cholecystokinin-8	9BKK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45	Single	9BLC	Cagrilintide (non-acylated)	9BLC-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
3.45	Single	9BUD	Cagrilintide	9BUD-CT-Cagrilintide-Gs/β1/γ2
3.45	Single	9EBO	GLP-1 (ACPC18)	9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
3.45	Consensus	angiotensin_on_gp	Orthosteric Ligand	at1_on_gp
3.45	Consensus	apelin_on	Orthosteric Ligand	8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
3.45	Consensus	apelin_on_gp	Orthosteric Ligand	8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
3.45	Consensus	at1_on_gp	Orthosteric Ligand	7F6G-AT₁-(Sar1)-Angiotensin II-Gq/β1/γ2
3.45	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
3.45	Consensus	gi_class-a	Orthosteric Ligand	gi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
3.45	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-(Sar1)-Angiotensin II-Gq/β1/γ2
3.45	Consensus	neuromedin-u_on	Orthosteric Ligand	nmur1_on nmur2_on
3.33	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/β1/γ2
3.33	Single	7TYH	Calcitonin	7TYH-CT (AMY2)-Calcitonin-Gs/β1/γ2; RAMP2
3.33	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
3.33	Single	7XV3	Lysophosphatidylserine (WJS)	7XV3-GPR174-Lysophosphatidylserine (WJS)-chim(NtGi1-Gs)/β1/γ2
3.33	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/β1/γ2
3.33	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/β1/γ2
3.33	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/β1/γ2
3.33	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/β1/γ2
3.33	Single	8WWK	MCH	8WWK-MCH1-MCH-Gi1/β1/γ2
3.33	Single	8WWM	MCH	8WWM-MCH1-MCH-Gi1/β1/γ2
3.33	Single	8XGO	TAK448	8XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
3.33	Single	8YG4	LA-PTH Analog	8YG4-PTH1-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
3.33	Consensus	calcitonin_on	Orthosteric Ligand	ctlike_on
3.33	Consensus	gi_apelin	Orthosteric Ligand	8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
3.33	Consensus	gi_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-CXCL8-Gi1/β1/γ2 6LFM-CXCR2-CXCL8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-CCL3-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
3.33	Consensus	neuromedin-u_on_gp	Orthosteric Ligand	nmur1_on_gp nmur2_on_gp
3.33	Consensus	opioid_on	Orthosteric Ligand	mop_on nop_on dop_on kop_on
3.33	Consensus	p2y10_on	Orthosteric Ligand	8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
3.33	Consensus	pac_on	Orthosteric Ligand	pac1_on
3.33	Consensus	sst5_on_gp	Orthosteric Ligand	8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
3.33	Consensus	vpac_on	Orthosteric Ligand	vpac1_on vpac2_on
3.23	Single	4XT3	CX3CL1	4XT3-US28-CX3CL1
3.23	Single	6FJ3	PTH	6FJ3-PTH1-PTH
3.23	Single	6NBF	LA-PTH Analog	6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2
3.23	Single	6P9Y	PACAP27	6P9Y-PAC₁-PACAP27-Gs/β1/γ2
3.23	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
3.23	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/β1/γ2
3.23	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
3.23	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.23	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/β1/γ2
3.23	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23	Single	9BLB	Cagrilintide (non-acylated)	9BLB-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
3.23	Single	9BLW	Cagrilintide (non-acylated)	9BLW-CT (AMY1)-Cagrilintide (non-acylated)-Gs/β1/γ2; RAMP1
3.23	Single	9BP3	Cagrilintide	9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
3.23	Single	9BUB	Cagrilintide	9BUB-CT-Cagrilintide-Gs/β1/γ2
3.23	Single	9KFK	Relaxin-3	9KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
3.23	Single	9P92	VIP	9P92-PAC₁-VIP-Gs/β1/γ2
3.23	Consensus	calcitonin_on_gp	Orthosteric Ligand	ctlike_on_gp
3.23	Consensus	ccr_off	Orthosteric Ligand	ccr2_off ccr5_off
3.23	Consensus	crf2_on_gp	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
3.23	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.23	Consensus	opioid_on_gp	Orthosteric Ligand	mop_on_gp nop_on_gp dop_on_gp kop_on_gp
3.23	Consensus	pac_on_gp	Orthosteric Ligand	pac1_on_gp
3.23	Consensus	vpac_on_gp	Orthosteric Ligand	vpac1_on_gp vpac2_on_gp
3.12	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
3.12	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/β1/γ2
3.12	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/β1/γ2
3.12	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
3.12	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/β1/γ2
3.12	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
3.12	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/β1/γ2
3.12	Single	8FEG	(DNCP)-Beta-Naloxamine	8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
3.12	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
3.12	Single	8WWL	MCH	8WWL-MCH1-MCH-Gi1/β1/γ2
3.12	Single	8ZH8	QRFP26	8ZH8-QRFP-QRFP26-Gq/β1/γ1
3.12	Single	9BUC	Cagrilintide	9BUC-CT-Cagrilintide-Gs/β1/γ2
3.12	Single	9P94	PACAP27	9P94-PAC₁-PACAP27-Gs/β1/γ2
3.12	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
3.12	Consensus	p2y10_on_gp	Orthosteric Ligand	8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
3.03	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/β1/γ2
3.03	Single	6NBH	LA-PTH Analog	6NBH-PTH1-LA-PTH Analog-Gs/β1/γ2
3.03	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
3.03	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
3.03	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/β1/γ2
3.03	Single	8F0K	Pramlintide Analogue San385	8F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
3.03	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
3.03	Single	8KGG	Lysophosphatidylserine (WJS)	8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
3.03	Single	8WWN	MCH	8WWN-MCH1-MCH-Gi1/β1/γ2
3.03	Single	9BQ3	Cagrilintide	9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
3.03	Single	9BYO	Exendin-3	9BYO-GLP-1-Exendin-3-Gs/β1/γ2
3.03	Single	9P93	VIP	9P93-PAC₁-VIP-Gs/β1/γ2
3.03	Consensus	ctlike_on_gp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.03	Consensus	pth1_on	Orthosteric Ligand	6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
3.03	Consensus	vip-pacap_on	Orthosteric Ligand	vpac_on pac_on
3.03	Consensus	vip-pacap_on_gp	Orthosteric Ligand	vpac_on_gp pac_on_gp
2.94	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
2.94	Consensus	bb2_on_gp	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
2.94	Consensus	bombesin_on	Orthosteric Ligand	bb2_on
2.94	Consensus	bombesin_on_gp	Orthosteric Ligand	bb2_on_gp
2.94	Consensus	class-a_class-b1_cons_on	Orthosteric Ligand	class-a_on class-b1_on
2.94	Consensus	crf1_on	Orthosteric Ligand	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF₁-Corticoliberin-1-Gs/β1/γ2
2.94	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
2.86	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
2.86	Single	8F2A	Pramlintide Analogue San385	8F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
2.86	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.78	Consensus	crf1_on_gp	Orthosteric Ligand	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF₁-Corticoliberin-1-Gs/β1/γ2
2.78	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_melanocortin gs_vasop-oxy
2.70	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/β1/γ2
2.70	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
2.63	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
2.50	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/β1/γ2
2.50	Consensus	pth2_on_gp	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
2.38	Single	8F2B	Pramlintide Analogue San45	8F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3

PDB Summary
PDB	9JQY
Class	A
SubFamily	Lipid
Type	Prostanoid
SubType	EP4
Species	Homo sapiens
Ligand	TG6-129
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	2.92
Date	2025-10-22
D.O.I.	To be published

Net Summary
I_min	3
Number of Linked Nodes	255
Number of Links	293
Number of Hubs	38
Number of Links mediated by Hubs	148
Number of Communities	8
Number of Nodes involved in Communities	51
Number of Links involved in Communities	69

Path Summary
Number Of Nodes in MetaPath	72
Number Of Links MetaPath	71
Number of Shortest Paths	64700
Length Of Smallest Path	3
Average Path Length	19.6605
Length of Longest Path	40
Minimum Path Strength	1.57
Average Path Strength	6.48009
Maximum Path Strength	24.33
Minimum Path Correlation	0.7
Average Path Correlation	0.927433
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	41.6411
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.5327
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • developmental process • multicellular organismal process • cellular developmental process • T-helper cell differentiation • hemopoiesis • cell activation • cell development • mononuclear cell differentiation • lymphocyte activation • lymphocyte differentiation • CD4-positive, alpha-beta T cell differentiation • leukocyte activation • alpha-beta T cell differentiation • T cell activation • immune system process • cell differentiation • CD4-positive, alpha-beta T cell activation • anatomical structure development • alpha-beta T cell activation • T cell differentiation • cellular process • leukocyte differentiation • regulation of defense response • regulation of biological process • response to stimulus • regulation of response to external stimulus • defense response • positive regulation of biological process • response to external stimulus • regulation of inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stimulus • regulation of response to stress • response to stress • positive regulation of defense response • inflammatory response • regulation of cytoskeleton organization • regulation of cellular process • regulation of cellular component organization • regulation of actin filament-based process • regulation of actin filament bundle assembly • cellular component biogenesis • cellular component organization • cellular component assembly • actin filament bundle organization • actin filament-based process • cellular component organization or biogenesis • stress fiber assembly • regulation of actin filament organization • actin cytoskeleton organization • actomyosin structure organization • actin filament organization • regulation of cellular component biogenesis • regulation of organelle organization • regulation of stress fiber assembly • organelle organization • contractile actin filament bundle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • cytoskeleton organization • immune response • cellular response to stimulus • signaling • intracellular signal transduction • cell communication • intracellular signaling cassette • MAPK cascade • ERK1 and ERK2 cascade • signal transduction • multicellular organism development • skeletal system development • animal organ development • bone development • system development • negative regulation of inflammatory response • negative regulation of response to stimulus • negative regulation of biological process • negative regulation of response to external stimulus • negative regulation of defense response • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • negative regulation of cellular process • cytokine production • regulation of cytokine production • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • negative regulation of metabolic process • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • response to mechanical stimulus • response to abiotic stimulus • negative regulation of locomotion • regulation of cell motility • negative regulation of eosinophil migration • eosinophil migration • eosinophil extravasation • negative regulation of cellular extravasation • cellular extravasation • myeloid leukocyte migration • regulation of cell migration • cell migration • regulation of immune system process • cell motility • negative regulation of eosinophil extravasation • negative regulation of cell migration • locomotion • regulation of leukocyte migration • regulation of eosinophil extravasation • granulocyte migration • regulation of eosinophil migration • leukocyte migration • negative regulation of leukocyte migration • negative regulation of immune system process • regulation of locomotion • negative regulation of cell motility • regulation of cellular extravasation • cellular response to mechanical stimulus • cellular response to abiotic stimulus • cellular response to external stimulus • cellular response to environmental stimulus • JNK cascade • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • positive regulation of cellular process • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of cytokine production • negative regulation of cellular component organization • protein-containing complex organization • negative regulation of protein-containing complex assembly • negative regulation of integrin activation • regulation of protein-containing complex assembly • protein-containing complex assembly • regulation of integrin activation • integrin activation • cellular anatomical structure • membrane • cell periphery • plasma membrane
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35408
Sequence	>9JQY_Chain_R S P V T I P A V M F I F G V V G N L V A I V V L C K S R K E Q K E T T F Y T L V C G L V T D L L G T L L V S P V T I A T Y M K G Q W P G G Q P L C E Y S T F I L L F F S L S L S I I C A M S V E R Y L A I N H A Y F Y S H Y V D K R L A G L T L F A V Y A S N V L F C A L P N M G L G S S R L Q Y P D T W C F I D W T T V T A H A A Y S Y M Y A G F S S F L I L A T V L C N V L V C G A L L R M H R Q F R R I A G A E I Q M V I L L I A T S L V V L I C S I P L V V R V F V N Q L Y Q P S L E R E V S K N P D L Q A I R I A S V N P I L D P W I Y I L L R K T V L S K A I L R Q F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5YHL	A	Lipid	Prostanoid	EP₄	Homo sapiens	PubChem 135121352	-	-	4.2	2018-12-05	doi.org/10.1038/s41589-018-0131-3
	5YWY	A	Lipid	Prostanoid	EP₄	Homo sapiens	ONO-AE3-208	-	-	3.2	2018-12-05	doi.org/10.1038/s41589-018-0131-3
	7D7M	A	Lipid	Prostanoid	EP₄	Homo sapiens	PGE2	-	Gs/β1/γ1	3.3	2020-11-18	doi.org/10.1016/j.str.2020.11.007
	7D7M (No Gprot)	A	Lipid	Prostanoid	EP₄	Homo sapiens	PGE2	-		3.3	2020-11-18	doi.org/10.1016/j.str.2020.11.007
	8GCM	A	Lipid	Prostanoid	EP₄	Homo sapiens	L-902688	-	Gi1/β1/γ2	3.5	2024-01-03	doi.org/10.1073/pnas.2216329120
	8GCM (No Gprot)	A	Lipid	Prostanoid	EP₄	Homo sapiens	L-902688	-		3.5	2024-01-03	doi.org/10.1073/pnas.2216329120
	8GCP	A	Lipid	Prostanoid	EP₄	Homo sapiens	PGE2	-	Gi1/β1/γ2	3.1	2024-01-03	doi.org/10.1073/pnas.2216329120
	8GCP (No Gprot)	A	Lipid	Prostanoid	EP₄	Homo sapiens	PGE2	-		3.1	2024-01-03	doi.org/10.1073/pnas.2216329120
	8GD9	A	Lipid	Prostanoid	EP₄	Homo sapiens	Rivenprost	-	Gs/β1/γ2	3.2	2024-01-03	doi.org/10.1073/pnas.2216329120
	8GD9 (No Gprot)	A	Lipid	Prostanoid	EP₄	Homo sapiens	Rivenprost	-		3.2	2024-01-03	doi.org/10.1073/pnas.2216329120
	8GDA	A	Lipid	Prostanoid	EP₄	Homo sapiens	L902688	-	Gs/β1/γ2	3.3	2024-01-03	doi.org/10.1073/pnas.2216329120
	8GDA (No Gprot)	A	Lipid	Prostanoid	EP₄	Homo sapiens	L902688	-		3.3	2024-01-03	doi.org/10.1073/pnas.2216329120
	8GDB	A	Lipid	Prostanoid	EP₄	Homo sapiens	PGE2	-	Gs/β1/γ2	3.1	2024-01-03	doi.org/10.1073/pnas.2216329120
	8GDB (No Gprot)	A	Lipid	Prostanoid	EP₄	Homo sapiens	PGE2	-		3.1	2024-01-03	doi.org/10.1073/pnas.2216329120
	9JQZ	A	Lipid	Prostanoid	EP₄	Homo sapiens	Grapiprant	-	-	2.65	2025-10-22	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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