Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:V48 2.825408
2R:R:N52 7.3375409
3R:R:L65 6.5175428
4R:R:N70 5.4175429
5R:R:F72 6.39143738
6R:R:F91 11.2325418
7R:R:V96 1.975406
8R:R:Q97 6.655406
9R:R:W101 5.994558
10R:R:M112 3.325407
11R:R:M114 4.6625407
12R:R:T120 7.1325418
13R:R:R133 6.39509
14R:R:F134 4.27408
15R:R:Y143 3.8375438
16R:R:Q152 6.82538
17R:R:W160 5.8325479
18R:R:E188 7.4975407
19R:R:Y192 5.68167608
20R:R:F201 11.9675409
21R:R:Y212 7.1175489
22R:R:L219 6.385448
23R:R:R342 9.8975447
24R:R:F355 9.605419
25R:R:W359 9.825619
26R:R:F362 10.7333618
27R:R:F363 10.348518
28R:R:I367 5.7275497
29R:R:Q369 5.2275464
30R:R:V377 5.7525465
31R:R:Y390 7.67518
32R:R:Y400 8.432529
33R:R:F407 6.685628
34L:L:?1 8.165831210
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:L88 R:R:Y390 1008.21NoYes088
2R:R:L83 R:R:L88 99.91996.92NoNo088
3R:R:L83 R:R:S393 99.38684.5NoNo089
4R:R:D80 R:R:S393 98.367511.78NoNo099
5R:R:D80 R:R:N52 97.928310.77NoYes099
6R:R:N52 R:R:P397 97.08589.77YesNo099
7R:R:P397 R:R:V55 96.5143.53NoNo099
8R:R:V55 R:R:Y400 96.31245.05NoYes099
9R:R:F407 R:R:Y400 54.53578.25YesYes289
10R:R:I73 R:R:Y400 41.135814.51NoYes289
11R:R:I73 R:R:N70 40.69115.66NoYes289
12R:R:F407 R:R:N70 43.32636.04YesYes289
13R:R:N70 R:R:T67 83.89875.85YesNo098
14R:R:P68 R:R:T67 82.72755.25NoNo078
15R:R:P68 R:R:R133 27.08414.32NoYes079
16R:R:P68 R:R:Q152 55.54946.32NoYes078
17R:R:F72 R:R:Q152 39.88455.86YesYes388
18R:R:F72 R:R:I129 26.34946.28YesNo089
19R:R:F72 R:R:I156 11.93037.54YesNo088
20L:L:?1 R:R:C119 11.26464.87YesNo008
21R:R:C119 R:R:W359 10.60167.84NoYes089
22R:R:F355 R:R:W359 22.913115.03YesYes199
23L:L:?1 R:R:F362 23.27514.2YesYes108
24R:R:F362 R:R:W359 18.493512.03YesYes189
25L:L:?1 R:R:F363 20.07627.47YesYes108
26R:R:F363 R:R:W359 11.09336.01YesYes189
27L:L:?1 R:R:L111 15.68155.94YesNo007
28L:L:?1 R:R:L187 14.49376.79YesNo007
29R:R:V116 R:R:Y192 10.42766.31NoYes098
30L:L:?1 R:R:V116 12.015910.97YesNo009
31R:R:S196 R:R:Y192 10.62375.09NoYes098
32L:L:?1 R:R:S196 11.21216.45YesNo109
33R:R:F355 R:R:I123 14.416310.05YesNo099
34R:R:I129 R:R:Y212 24.93238.46NoYes099
35R:R:S130 R:R:Y212 14.80310.17NoYes899
36R:R:L211 R:R:S130 13.3977.51NoNo089
37R:R:M345 R:R:R133 23.62023.72NoYes089
38R:R:F134 R:R:L211 10.4584.87YesNo088
39R:R:F216 R:R:M345 22.25849.95NoNo078
40R:R:F216 R:R:R342 19.41613.21NoYes077
41R:R:L219 R:R:R342 12.07946.07YesYes487
42R:R:Q152 R:R:R151 13.62635.84YesNo388
43R:R:R151 R:R:Y143 10.56024.12NoYes388
44R:R:N392 R:R:W359 11.45526.78NoYes199
45R:R:F362 R:R:V385 10.91933.93YesNo087
46R:R:F362 R:R:H366 10.73718.1YesNo087
47R:R:T386 R:R:Y390 16.77264.99NoYes068
48R:R:I123 R:R:P204 11.54363.39NoNo099
49L:L:?1 R:R:Y390 74.7975.75YesYes108
50R:R:F362 R:R:T386 16.42736.49YesNo086
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L88 R:R:Y390 8.21 0 No Yes 8 8 2 1
R:R:L111 R:R:L90 5.54 0 No No 7 6 1 2
R:R:E95 R:R:F91 12.83 1 No Yes 6 8 2 1
R:R:F91 R:R:W387 14.03 1 Yes No 8 8 1 2
R:R:F91 R:R:Y390 11.35 1 Yes Yes 8 8 1 1
L:L:?1 R:R:F91 6.72 1 Yes Yes 0 8 0 1
R:R:E95 R:R:W387 8.72 1 No No 6 8 2 2
R:R:L111 R:R:W101 4.56 0 No Yes 7 8 1 2
L:L:?1 R:R:L111 5.94 1 Yes No 0 7 0 1
R:R:L187 R:R:M112 5.65 0 No Yes 7 7 1 2
R:R:D115 R:R:Y390 8.05 1 No Yes 9 8 1 1
L:L:?1 R:R:D115 23.31 1 Yes No 0 9 0 1
R:R:V116 R:R:Y192 6.31 0 No Yes 9 8 1 2
L:L:?1 R:R:V116 10.97 1 Yes No 0 9 0 1
R:R:C119 R:R:W359 7.84 0 No Yes 8 9 1 2
L:L:?1 R:R:C119 4.87 1 Yes No 0 8 0 1
R:R:S200 R:R:T120 9.59 1 No Yes 8 8 1 2
L:L:?1 R:R:L187 6.79 1 Yes No 0 7 0 1
R:R:S196 R:R:Y192 5.09 1 No Yes 9 8 1 2
R:R:S196 R:R:S200 4.89 1 No No 9 8 1 1
L:L:?1 R:R:S196 6.45 1 Yes No 0 9 0 1
R:R:F363 R:R:S197 3.96 1 Yes No 8 8 1 2
L:L:?1 R:R:S200 3.68 1 Yes No 0 8 0 1
R:R:F201 R:R:F363 24.65 0 Yes Yes 9 8 2 1
R:R:F362 R:R:W359 12.03 1 Yes Yes 8 9 1 2
R:R:F363 R:R:W359 6.01 1 Yes Yes 8 9 1 2
R:R:F362 R:R:F363 9.65 1 Yes Yes 8 8 1 1
R:R:F362 R:R:H366 18.1 1 Yes No 8 7 1 2
R:R:F362 R:R:V385 3.93 1 Yes No 8 7 1 2
R:R:F362 R:R:T386 6.49 1 Yes No 8 6 1 2
L:L:?1 R:R:F362 14.2 1 Yes Yes 0 8 0 1
L:L:?1 R:R:F363 7.47 1 Yes Yes 0 8 0 1
R:R:T386 R:R:Y390 4.99 0 No Yes 6 8 2 1
L:L:?1 R:R:Y390 5.75 1 Yes Yes 0 8 0 1
R:R:A167 R:R:V116 3.39 0 No No 9 9 2 1
R:R:L187 R:R:V193 2.98 0 No No 7 7 1 2
R:R:G99 R:R:S94 1.86 0 No No 6 7 2 1
L:L:?1 R:R:S94 1.84 1 Yes No 0 7 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single5WIUNemonapride5WIU-D4-Nemonapride
100.00Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
100.00Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
76.92Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
76.92Single6H7MSalbutamol6H7M-β1-Salbutamol
73.33Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
73.33Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
71.43Single2Y03Isoprenaline2Y03-β1-Isoprenaline
71.43Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
71.43Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
71.43Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
71.43Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
71.43Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
71.43Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
71.43Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
71.43Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
71.43Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
71.43Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
70.59Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
69.23Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
69.23Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
69.23Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
69.23Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
69.23Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
69.23Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
69.23Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
69.23Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8GGIEpinephrine8GGI-β2-Epinephrine
69.23Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
68.75Single6H7LDobutamine6H7L-β1-Dobutamine
66.67Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
66.67Single6H7JIsoprenaline6H7J-β1-Isoprenaline
66.67Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
66.67Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
66.67Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
66.67Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
64.71Single8X5YAstemizole8X5Y-H1-Astemizole
64.29Single2Y04Salbutamol2Y04-β1-Salbutamol
64.29Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
64.29Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
64.29Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
64.29Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
64.29Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
64.29Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
64.29Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
64.29Single7WC7Lisuride7WC7-5-HT2A-Lisuride
64.29Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
64.29Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
64.29Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
64.29Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
64.29Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Single8GGJEpinephrine8GGJ-β2-Epinephrine
64.29Single8GGNEpinephrine8GGN-β2-Epinephrine
64.29Single8GGOEpinephrine8GGO-β2-Epinephrine
64.29Single8GGUEpinephrine8GGU-β2-Epinephrine
64.29Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
64.29Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
64.29Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
64.29Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
64.29Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
64.29Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
64.29Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
64.29Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
64.29Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
62.50Single4AMIBucindolol4AMI-β1-Bucindolol
62.50Single4LDEBI1671074LDE-β2-BI167107
62.50Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
62.50Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
62.50Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
62.50Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
62.50Single8JJ8Formoterol8JJ8-β2-Formoterol
62.50Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
61.54Single6KUXRS-799486KUX-α2a-RS-79948
61.54Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
61.54Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
61.54Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
61.54Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
61.54Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
61.54Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
61.54Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
61.54Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Single8GGVEpinephrine8GGV-β2-Epinephrine
61.54Single8GGWEpinephrine8GGW-β2-Epinephrine
61.54Single8GGXEpinephrine8GGX-β2-Epinephrine
61.54Single8GH0Epinephrine8GH0-β2-Epinephrine
61.54Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
61.54Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
61.54Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
61.11Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
60.00Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
60.00Single2Y00Dobutamine2Y00-β1-Dobutamine
60.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
60.00Single7WC6LSD7WC6-5-HT2A-LSD
60.00Single7XKAEpinephrine7XKA-β2-Epinephrine
60.00Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
60.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
60.00Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
60.00Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
60.00Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
60.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
60.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
60.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
60.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
58.82Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
58.82Single6IBLArformoterol6IBL-β1-Arformoterol
58.82Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
58.82Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
57.14Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
57.14Single6A94Zotepine6A94-5-HT2A-Zotepine
57.14Single6PS4ICI 118-5516PS4-β2-ICI 118-551
57.14Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
57.14Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
57.14Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
57.14Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
57.14Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
57.14Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
57.14Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
57.14Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
57.14Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
57.14Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Single8GGKEpinephrine8GGK-β2-Epinephrine
57.14Single8GGLEpinephrine8GGL-β2-Epinephrine
57.14Single8GGMEpinephrine8GGM-β2-Epinephrine
57.14Single8GGPEpinephrine8GGP-β2-Epinephrine
57.14Single8GGQEpinephrine8GGQ-β2-Epinephrine
57.14Single8GGTEpinephrine8GGT-β2-Epinephrine
57.14Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
57.14Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
57.14Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
57.14Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
57.14Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
57.14Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
57.14Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
57.14Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
56.25Single3P0GBI1671073P0G-β2-BI167107
56.25Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
56.25Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
56.25Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
56.25Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
56.25Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
56.25Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
56.25Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
56.25Single6WGTLSD6WGT-5-HT2A-LSD
56.25Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
56.25Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
56.25Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
56.25Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
56.25Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
56.25Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
56.25Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
56.25Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
56.25Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
56.25Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
56.25Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
55.56Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Single3PBLEticlopride3PBL-D3-Eticlopride
53.85Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
53.85Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
53.85Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
53.85Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
53.85Single8GGSEpinephrine8GGS-β2-Epinephrine
53.85Single8GGYEpinephrine8GGY-β2-Epinephrine
53.85Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
53.85Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
53.85Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
53.85Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
53.85Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
53.85Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
53.33Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
53.33Single2Y01Dobutamine2Y01-β1-Dobutamine
53.33Single2Y02Carmoterol2Y02-β1-Carmoterol
53.33Single3NY8ICI 118-5513NY8-β2-ICI 118-551
53.33Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
53.33Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
53.33Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
53.33Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
53.33Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
53.33Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
53.33Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
53.33Single6PS1Timolol6PS1-β2-Timolol
53.33Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
53.33Single7BU7BI1671077BU7-β1-BI167107
53.33Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
53.33Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
53.33Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
53.33Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
53.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
53.33Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
53.33Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
53.33Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
53.33Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
53.33Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.33Single8JJOAlprenolol8JJO-β2-Alprenolol
53.33Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
53.33Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.33Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
53.33Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
53.33Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
53.33Single8X64Desloratadine8X64-H1-Desloratadine
53.33Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
53.33Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
53.33Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
53.33Consensustar_onOrthosteric Ligandta1_on
52.94Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
52.94Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
52.94Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
52.94Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
52.94Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
52.94Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
52.94Single8JJLOlodaterol8JJL-β2-Olodaterol
52.94Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
52.94Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
52.94Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
50.00Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
50.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
50.00Single5C1MBU725C1M-μ-BU72
50.00Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
50.00Single5DHHSB-6121115DHH-NOP-SB-612111
50.00Single5TVNLSD5TVN-5-HT2B-LSD
50.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
50.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
50.00Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
50.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
50.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
50.00Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
50.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
50.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
50.00Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
50.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
50.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
50.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
50.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
50.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
50.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
50.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
50.00Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
50.00Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
50.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
50.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
50.00Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
50.00Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
50.00Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
50.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
50.00Consensusendothelin_offOrthosteric Ligandetb_off
50.00Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
50.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
50.00Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.37Single3NY9PubChem 9131033NY9-β2-PubChem 913103
47.06Single2YDVNECA2YDV-A2A-NECA
47.06Single4U15Tiotropium4U15-M3-Tiotropium
47.06Single4UHRCGS216804UHR-A2A-CGS21680
47.06Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
47.06Single5G53NECA5G53-A2A-NECA-Gs
47.06Single5V54Methiothepin5V54-5-HT1B-Methiothepin
47.06Single6J21Aprepitant6J21-NK1-Aprepitant
47.06Single6OL9Tiotropium6OL9-M5-Tiotropium
47.06Single6TQ7SB-3348676TQ7-OX1-SB-334867
47.06Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
47.06Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
47.06Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
47.06Single8E0GBU728E0G-μ-BU72
47.06Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
47.06Consensus5ht1_offOrthosteric Ligand5ht1b_off
47.06Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
47.06Consensus5ht5_offOrthosteric Ligand5ht5a_off
47.06Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
47.06Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
47.06Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
47.06Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
47.06Consensushistamine_offOrthosteric Ligandh1_off
47.06Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
47.06Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
47.06Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
46.67Single6IQLL7458706IQL-D4-L745870
46.67Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
46.67Single6TPGEMPA6TPG-OX2-EMPA
46.67Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
46.67Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
46.67Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
46.67Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
46.67Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
46.67Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
46.67Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
46.67Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
46.67Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
46.67Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
46.67Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67Consensus5ht5_onOrthosteric Ligand5ht5a_on
46.67Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
46.67Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
46.67Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
46.15Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
46.15Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Single8GGREpinephrine8GGR-β2-Epinephrine
46.15Single8GGZEpinephrine8GGZ-β2-Epinephrine
46.15Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
46.15Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
46.15Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
45.45Single7C61Ergotamine7C61-5-HT1B-Ergotamine
45.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
45.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
45.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
45.00Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
45.00Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
44.44Single5CXVTiotropium5CXV-M1-Tiotropium
44.44Single6MXTSalmeterol6MXT-β2-Salmeterol
44.44Single6ZG4HTL00099366ZG4-M1-HTL0009936
44.44Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
44.44Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
44.44Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
44.44Single7YITNalfurafine7YIT-κ-Nalfurafine
44.44Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
44.44Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
44.44Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
44.44Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
44.44Consensusgs_steroidOrthosteric Ligandgs_bileacid
44.44Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
44.44Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
43.75Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
43.75Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
43.75Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
43.75Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
43.75Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
43.75Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
43.75Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
43.75Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
43.75Single6TOTLemborexant6TOT-OX1-Lemborexant
43.75Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
43.75Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
43.75Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
43.75Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
43.75Single7UL4Alvimopan7UL4-μ-Alvimopan
43.75Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
43.75Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
43.75Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
43.75Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
43.75Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
43.75Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
43.75Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
43.75Consensushistamine_onOrthosteric Ligandh1_on h4_on
43.48Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
42.86Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
42.86Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
42.86Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
42.86Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
42.86Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
42.86Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.86Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
42.86Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
42.86Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
42.11Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
42.11Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
42.11Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
42.11Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
42.11Single7UM4AS26747237UM4-5-HT5A-AS2674723
42.11Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
42.11Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.11Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
42.11Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
42.11Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
42.11Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
42.11Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
42.11Consensussteroid_onOrthosteric Ligandbileacid_on
41.67Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
41.18Single5WQCEMPA5WQC-OX2-EMPA
41.18Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
41.18Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
41.18Single6PS6Timolol6PS6-β2-Timolol
41.18Single6TP6Filorexant6TP6-OX1-Filorexant
41.18Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
41.18Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
41.18Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
41.18Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
41.18Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
41.18Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
41.18Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
41.18Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.91Single6PT2KGCHM076PT2-δ-KGCHM07
40.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
40.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
40.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
40.00Single4UG2CGS216804UG2-A2A-CGS21680
40.00Single6AKXA4R6AKX-CCR5-A4R
40.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
40.00Single6B73PubChem 1319551386B73-κ-PubChem 131955138
40.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
40.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
40.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
40.00Single7SK9CCX6627SK9-ACKR3-CCX662
40.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
40.00Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
40.00Single8IHKAcifran8IHK-HCA3-Acifran
40.00Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single8IWESpermidine8IWE-TAAR9-Spermidine
40.00Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
40.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
40.00Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
40.00Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
38.89Single4DJHJDTic4DJH-κ-JDTic
38.89Single4RWADIPP-NH24RWA-δ-DIPP-NH2
38.89Single5X93K-87945X93-ETB-K-8794
38.89Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
38.89Single6J20Aprepitant6J20-NK1-Aprepitant
38.89Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
38.89Single7B6WCyclazosin7B6W-α1b-Cyclazosin
38.89Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
38.89Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
38.89Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
38.89Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
38.89Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
38.89Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
38.89Consensusa2_onOrthosteric Liganda2a_on a2b_on
38.89Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
38.89Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
38.89Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
38.89Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
38.46Single6TQ9SB-4081246TQ9-OX1-SB-408124
38.46Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
38.46Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.46Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
38.46Consensussensory_onOrthosteric Ligandopsin_on
38.10Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
38.10Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
38.10Consensussst_onOrthosteric Ligandsst2_on sst4_on
37.50Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
37.50Single3RZECidoxepin3RZE-H1-Cidoxepin
37.50Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
37.50Single4MBSMaraviroc4MBS-CCR5-Maraviroc
37.50Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
37.50Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
37.50Single4ZJCSB-6740424ZJC-OX1-SB-674042
37.50Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
37.50Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
37.50Single6TPNHTL66416TPN-OX2-HTL6641
37.50Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
37.50Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
37.50Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
37.50Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
37.50Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
37.50Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
37.50Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
37.50Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
37.50Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
37.50Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
37.50Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
37.50Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
37.50Consensussensory_offOrthosteric Ligandopsin_off
36.84Single6A93Risperidone6A93-5-HT2A-Risperidone
36.84Single6CM4Risperidone6CM4-D2-Risperidone
36.84Single6HLPNetupitant6HLP-NK1-Netupitant
36.84Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
36.84Single7DFPSpiperone7DFP-D2-Spiperone
36.84Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.84Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.84Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.84Single8JWZAB9288JWZ-A2A-AB928-Na
36.84Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
36.36Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
36.36Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
36.36Single6HLOAprepitant6HLO-NK1-Aprepitant
36.36Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
36.36Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
36.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
35.71Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
35.71Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
35.71Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
35.71Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
35.71Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
35.29Single4DAJTiotropium4DAJ-M3-Tiotropium
35.29Single4EJ4Naltrindole4EJ4-δ-Naltrindole
35.29Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
35.29Single4MQSIperoxo4MQS-M2-Iperoxo
35.29Single4U14Tiotropium4U14-M3-Tiotropium
35.29Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
35.29Single5DSGTiotropium5DSG-M4-Tiotropium
35.29Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
35.29Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
35.29Single6DRXLisuride6DRX-5-HT2B-Lisuride
35.29Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
35.29Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
35.29Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
35.29Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
35.29Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
35.29Single8K5DGSK2560738K5D-HCA2-GSK256073
35.29Single8X63Mepyramine8X63-H1-Mepyramine
35.29Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
35.29Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
35.29Consensusgi_hcarOrthosteric Ligandgi_hca
35.29Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
35.29Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
35.29Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
35.29Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
35.29Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
35.29Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
35.29Consensustachykinin_offOrthosteric Ligandnk1_off
35.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
35.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
35.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
35.00Single6K1QIRL25006K1Q-ETB-IRL2500
35.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
35.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
35.00Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.00Consensusorexin_onOrthosteric Ligandox2_on
34.78Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
34.78Consensusangiotensin_onOrthosteric Ligandat1_on
34.78Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
34.78Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
34.78Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
34.62Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
33.33Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
33.33Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
33.33Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
33.33Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
33.33Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
33.33Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
33.33Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
33.33Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
33.33Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
33.33Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
33.33Single6D26Fevipiprant6D26-DP2-Fevipiprant
33.33Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
33.33Single6HLLCP999946HLL-NK1-CP99994
33.33Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
33.33Single6PT3DPI-2876PT3-δ-DPI-287
33.33Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
33.33Single6TP4ACT-4622066TP4-OX1-ACT-462206
33.33Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
33.33Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
33.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
33.33Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
33.33Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
33.33Single7SRQLSD7SRQ-5-HT2B-LSD
33.33Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
33.33Single7XN9L-054,5227XN9-SST2-L-054,522
33.33Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
33.33Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
33.33Single8EA0Iperoxo8EA0-M3-Iperoxo
33.33Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
33.33Single8GH1Epinephrine8GH1-β2-Epinephrine
33.33Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
33.33Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
33.33Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
33.33Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
33.33Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
33.33Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8K5BNiacin8K5B-HCA2-Niacin
33.33Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
33.33Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
33.33Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
33.33Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
33.33Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
33.33Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
33.33Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
33.33Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
33.33Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
33.33Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
32.14Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
32.14Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
32.14Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
31.82Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
31.82Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
31.82Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
31.82Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
31.82Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
31.58Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
31.58Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
31.58Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
31.58Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
31.58Single6E59L-7607356E59-NK1-L-760735
31.58Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
31.58Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
31.58Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
31.58Single7TUYGSK682753A7TUY-GPR183-GSK682753A
31.58Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
31.58Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
31.58Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
31.58Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
31.58Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
31.58Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
31.58Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
31.58Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
31.58Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
31.58Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
31.58Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
31.58Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
31.58Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
31.58Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
31.58Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
31.25Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
31.25Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
31.25Single5WS3EMPA5WS3-OX2-EMPA
31.25Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
31.25Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
31.25Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
31.25Single6TODEMPA6TOD-OX1-EMPA-Na
31.25Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
31.25Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
31.25Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
31.25Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
31.25Single7XRRLemborexant7XRR-OX2-Lemborexant
31.25Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
31.25Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
31.25Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
31.25Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
31.25Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
31.25Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
31.25Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
31.25Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Consensusgt_class-aOrthosteric Ligandgt_opsin
31.25Consensusgt_opsinOrthosteric Ligandgt_sensory
31.25Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
31.25Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
31.25Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
31.25Consensusorexin_offOrthosteric Ligandox2_off ox1_off
30.77Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
30.77Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
30.77Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
30.77Single7WC4Serotonin7WC4-5-HT2A-Serotonin
30.77Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
30.77Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Single3QAKUK-4320973QAK-A2A-UK-432097
30.43Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
30.43Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
30.43Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
30.43Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
30.43Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
30.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
30.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
30.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
30.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
30.00Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
30.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
30.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
30.00Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
30.00Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
30.00Consensusdp_offOrthosteric Liganddp2_off
30.00Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
30.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
29.41Single2YDOAdenosine2YDO-A2A-Adenosine
29.41Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
29.41Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
29.41Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
29.41Single6DS0Ly2660976DS0-5-HT2B-Ly266097
29.41Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
29.41Single6TP3Nemorexant6TP3-OX1-Nemorexant
29.41Single6V9SGTPL114036V9S-OX1-GTPL11403
29.41Single6VI4JDTic6VI4-κ-JDTic
29.41Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
29.41Single6ZG9GSK10347026ZG9-M1-GSK1034702
29.41Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
29.41Single7VODCariprazine7VOD-5-HT2A-Cariprazine
29.41Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
29.41Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
29.41Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
29.41Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
29.41Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
29.41Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
29.41Single8K5CAcipimox8K5C-HCA2-Acipimox
29.41Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
29.41Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
29.41Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
29.41Consensushca_onOrthosteric Ligandhca2_on hca3_on
29.41Consensushcar_onOrthosteric Ligandhca_on
29.41Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
29.41Consensuss1p_offOrthosteric Ligands1p1_off
29.17Single5WF5UK-4320975WF5-A2A-UK-432097
29.17Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
29.17Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
29.17Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
29.17Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
29.03Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
28.57Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
28.57Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
28.57Single7EZCUKA7EZC-A2A-UKA
28.57Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
28.57Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
28.57Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
28.57Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
28.57Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
28.57Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
28.57Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
28.57Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
28.57Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
28.57Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
28.57Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
28.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
28.00Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
28.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
28.00Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Single4YAYZD-71554YAY-AT1-ZD-7155
27.78Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
27.78Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
27.78Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
27.78Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
27.78Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
27.78Single7F83PF-051904577F83-Ghrelin-PF-05190457
27.78Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
27.78Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
27.78Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
27.78Single8CU6LJ-45178CU6-A2A-LJ-4517
27.78Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
27.78Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
27.78Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
27.78Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
27.78Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
27.78Consensusadenosine_onOrthosteric Liganda1_on a2_on
27.78Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
27.78Consensusblt_onOrthosteric Ligandblt1_on
27.78Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
27.78Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
27.78Consensusleuko_onOrthosteric Ligandblt_on
27.78Consensusnucleotide_onOrthosteric Ligandadenosine_on
27.27Single5WF6UK-4320975WF6-A2A-UK-432097
27.27Single5ZTYAM102575ZTY-CB2-AM10257
27.27Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
27.27Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
27.27Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
27.27Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
27.27Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
27.27Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
27.27Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
27.27Consensuslpl_offOrthosteric Ligands1p_off lpa_off
27.27Consensuslpl_onOrthosteric Ligands1p_on lpa_on
26.92Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.92Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
26.92Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
26.92Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
26.92Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
26.67Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
26.67Single3UZAGTPL92363UZA-A2A-GTPL9236
26.67Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
26.67Single6ME5Agomelatine6ME5-MT1-Agomelatine
26.67Single6ME9Ramelteon6ME9-MT2-Ramelteon
26.67Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
26.67Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
26.67Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
26.67Single7WC5Psilocin7WC5-5-HT2A-Psilocin
26.67Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
26.67Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
26.67Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
26.67Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
26.32Single5XPRBosentan5XPR-ETB-Bosentan
26.32Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
26.32Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
26.32Single7C4SS1P7C4S-S1P3-S1P
26.32Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
26.32Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
26.32Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
26.32Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
26.32Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
26.32Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
26.32Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
26.32Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
26.32Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
26.32Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
26.32Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
26.09Single7F8XNN90567F8X-CCKA-NN9056
26.09Single7QA8Peptide7QA8-STE2-Peptide
26.09Single7QA8Peptide7QA8-STE2-Peptide
26.09Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
26.09Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
26.09Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
26.09Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
26.09Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
26.09Consensusclass-d_offOrthosteric Ligandste2_off
26.09Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
26.09Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
26.09Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
25.93Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
25.93Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
25.00Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
25.00Single3OE9IT1t3OE9-CXCR4-IT1t
25.00Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
25.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
25.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
25.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
25.00Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
25.00Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
25.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
25.00Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
25.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
25.00Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
25.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
25.00Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
25.00Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
25.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
25.00Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
25.00Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
25.00Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
25.00Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
25.00Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
25.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
25.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
25.00Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
25.00Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
25.00Consensusendothelin_onOrthosteric Ligandetb_on eta_on
25.00Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
25.00Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
25.00Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
25.00Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.00Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
25.00Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
25.00Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
25.00Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
25.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
24.14Single6IGLIRL16206IGL-ETB-IRL1620
24.14Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
24.14Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
24.14Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
24.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
24.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
24.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
24.00Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
23.81Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
23.81Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
23.81Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
23.81Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
23.81Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
23.81Single7K15MKD0467K15-BLT1-MKD046-Na
23.81Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
23.81Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
23.81Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
23.81Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
23.81Single8WU1KCA8WU1-CB1-KCA-Arrestin1
23.81Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
23.81Consensusblt_offOrthosteric Ligandblt1_off
23.81Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
23.81Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
23.81Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
23.81Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
23.81Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
23.81Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
23.81Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
23.81Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
23.81Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
23.81Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
23.53Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
23.53Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
23.53Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
23.53Single4S0VSuvorexant4S0V-OX2-Suvorexant
23.53Single6TPJSuvorexant6TPJ-OX2-Suvorexant
23.53Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
23.53Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
23.53Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
23.53Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
23.53Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
23.53Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
23.53Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
23.53Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
23.33Single6IGKEndothelin-36IGK-ETB-Endothelin-3
23.08Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
23.08Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
23.08Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
23.08Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
23.08Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
23.08Consensusclass-d_onOrthosteric Ligandste2_on
23.08Consensusgi_class-dOrthosteric Ligandgi_ste
23.08Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.73Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
22.73Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
22.73Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
22.73Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
22.73Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
22.73Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
22.73Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
22.73Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
22.73Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.73Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
22.73Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
22.73Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
22.58Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
22.22Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
22.22Single7T32ZM2413857T32-A2A-ZM241385
22.22Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
22.22Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
22.22Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
22.22Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
22.22Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
22.22Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
22.22Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
22.22Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
22.22Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
22.22Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
22.22Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
22.22Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
21.88Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
21.74Single5EE7MK08935EE7-Glucagon-MK0893
21.74Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
21.74Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
21.74Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
21.74Consensusclass-d_offOrthosteric Ligandste2_off
21.74Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
21.74Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
21.43Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
21.43Consensusclass-d_onOrthosteric Ligandste2_on
21.43Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
21.43Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
21.43Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
21.05Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
21.05Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
21.05Single6D27CAY104716D27-DP2-CAY10471
21.05Single6GPSMK08126GPS-CCR2-MK0812
21.05Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
21.05Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
21.05Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
21.05Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
21.05Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
21.05Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
21.05Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
21.05Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
21.05Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
21.05Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
21.05Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
21.05Consensuscck_offOrthosteric Ligandccka_off
21.05Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
20.83Single4XT1Fractalkine4XT1-US28-Fractalkine
20.83Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
20.83Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
20.83Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
20.83Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
20.69Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.69Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
20.69Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
20.69Consensusgi_class-dOrthosteric Ligandgi_ste
20.69Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
20.69Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.69Consensusgo_class-b1Orthosteric Ligandgo_crf
20.69Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.00Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
20.00Single5CGCHTL142425CGC-mGlu5-HTL14242
20.00Single5N2SPSB365N2S-A1-PSB36
20.00Single5NM2ZM2413855NM2-A2A-ZM241385-Na
20.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
20.00Single6GPXMK08126GPX-CCR2-MK0812
20.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
20.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
20.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
20.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
20.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
20.00Single7SINNPS-21437SIN-CaS-NPS-2143
20.00Single7SINNPS-21437SIN-CaS-NPS-2143
20.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
20.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
20.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
20.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
20.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
20.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
20.00Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
20.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
20.00Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
20.00Single8IY6Endothelin-18IY6-ETB-Endothelin-1
20.00Single8QOTNanobody E8QOT-μ-Nanobody E
20.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
20.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
20.00Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.35Single5GLHEndothelin-15GLH-ETB-Endothelin-1
19.35Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
19.23Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
19.23Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
19.23Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
19.05Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
19.05Single5XR8AM8415XR8-CB1-AM841
19.05Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
19.05Single7EPENAM5637EPE-mGlu-NAM563
19.05Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
19.05Single7W41PD1762527W41-BB2-PD176252
19.05Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
19.05Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
19.05Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
19.05Consensusadenosine_offOrthosteric Liganda1_off a2_off
19.05Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
19.05Consensusbombesin_offOrthosteric Ligandbb2_off
19.05Consensuscck_onOrthosteric Ligandccka_on cckb_on
19.05Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
19.05Consensuschemerin_onOrthosteric Ligandcml1_on
19.05Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
19.05Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
19.05Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
19.05Consensuslpa_offOrthosteric Ligandlpa1_off
19.05Consensuslpa_onOrthosteric Ligandlpa1_on
19.05Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
19.05Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
18.75Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
18.75Single3OE6IT1t3OE6-CXCR4-IT1t
18.75Single3OE8IT1t3OE8-CXCR4-IT1t
18.75Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
18.75Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.75Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
18.75Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
18.75Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
18.75Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
18.75Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
18.52Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
18.52Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
18.52Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.52Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
18.52Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
18.52Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
18.52Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
18.18Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
18.18Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
18.18Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
18.18Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
18.18Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
18.18Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
18.18Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
18.18Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
18.18Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
18.18Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
18.18Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
18.18Consensusgi_class-fOther Ligandgi_frizzled
18.18Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
18.18Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
17.86Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
17.86Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
17.86Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
17.86Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
17.86Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
17.86Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.86Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
17.86Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
17.65Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
17.65Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
17.65Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
17.65Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
17.65Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
17.65Consensusclass-t_onOrthosteric Ligandtaste2_on
17.65Consensusgs_class-tOrthosteric Ligandgs_taste
17.65Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
17.65Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
17.65Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
17.65Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
17.39Single5CGDHTL142425CGD-mGlu5-HTL14242
17.39Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
17.39Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
17.39Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
17.39Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
17.39Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
17.39Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
17.39Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
17.39Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
17.39Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
17.39Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
17.39Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
17.24Single4XT3Fractalkine4XT3-US28-Fractalkine
17.24Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
17.24Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
17.24Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
17.14Consensuspth_onOrthosteric Ligandpth1_on pth2_on
16.67Single3ODUIT1t3ODU-CXCR4-IT1t
16.67Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
16.67Single5K2DZM2413855K2D-A2A-ZM241385
16.67Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
16.67Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
16.67Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
16.67Single6JZHZM2413856JZH-A2A-ZM241385-Na
16.67Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
16.67Single6PS7ZM2413856PS7-A2A-ZM241385-Na
16.67Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
16.67Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
16.67Single7BR3Elagolix7BR3-GnRH1-Elagolix
16.67Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
16.67Single7F8ULintitript7F8U-CCKA-Lintitript
16.67Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
16.67Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
16.67Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
16.67Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
16.67Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
16.67Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
16.67Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
16.67Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
16.67Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
16.67Single8GNGIstradefylline8GNG-A2A-Istradefylline
16.67Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
16.67Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
16.67Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
16.67Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
16.67Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
16.67Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
16.67Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
16.67Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
16.67Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.22Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
16.22Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.13Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
16.13Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
16.13Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
16.13Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
16.13Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
16.13Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.13Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
16.13Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
16.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
16.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
16.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
16.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
16.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
16.00Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
15.79Single3REYPubChem 56973REY-A2A-PubChem 5697
15.79Single5IU4ZM2413855IU4-A2A-ZM241385-Na
15.79Single5IU7Q274563465IU7-A2A-Q27456346-Na
15.79Single5IUBQ274563445IUB-A2A-Q27456344-Na
15.79Single5JTBZM2413855JTB-A2A-ZM241385
15.79Single5K2BZM2413855K2B-A2A-ZM241385-Na
15.79Single5K2CZM2413855K2C-A2A-ZM241385-Na
15.79Single5NLXZM2413855NLX-A2A-ZM241385-Na
15.79Single5NM4ZM2413855NM4-A2A-ZM241385-Na
15.79Single5UVIZM2413855UVI-A2A-ZM241385
15.79Single6AQFZM2413856AQF-A2A-ZM241385
15.79Single6FFIMMPEP6FFI-mGlu5-MMPEP
15.79Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
15.79Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
15.79Single6TPKRetosiban6TPK-OT-Retosiban
15.79Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
15.79Single7AROLUF58337ARO-A2A-LUF5833-Na
15.79Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
15.79Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.79Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
15.79Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
15.79Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
15.79Consensusgnrh_offOrthosteric Ligandgnrh1_off
15.79Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
15.79Consensusvasopressin-ot_offOrthosteric Ligandot_off
15.62Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
15.62Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
15.62Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
15.38Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
15.38Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
15.38Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
15.38Single7SK5CXCL127SK5-ACKR3-CXCL12
15.38Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
15.38Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
15.38Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
15.38Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
15.38Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
15.15Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
15.15Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
15.15Consensusglp_onOrthosteric Ligandglp1_on glp2_on
15.00Single3EMLZM2413853EML-A2A-ZM241385
15.00Single4EIYZM2413854EIY-A2A-ZM241385-Na
15.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
15.00Single5K2AZM2413855K2A-A2A-ZM241385-Na
15.00Single5OLGZM2413855OLG-A2A-ZM241385-Na
15.00Single5TGZAM65385TGZ-CB1-AM6538
15.00Single5UENDU1725UEN-A1-DU172
15.00Single5VRAZM2413855VRA-A2A-ZM241385-Na
15.00Single6FFHFenobam6FFH-mGlu5-Fenobam
15.00Single6IIVDaltroban6IIV-TP-Daltroban
15.00Single6LPJZM2413856LPJ-A2A-ZM241385-Na
15.00Single6LPKZM2413856LPK-A2A-ZM241385-Na
15.00Single6S0LZM2413856S0L-A2A-ZM241385
15.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
15.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
15.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
15.00Single7PYRPSB-21157PYR-A2A-PSB-2115
15.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
15.00Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
15.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
15.00Consensusa2_offOrthosteric Liganda2a_off
15.00Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
15.00Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
15.00Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
15.00Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
15.00Consensushcar_offOrthosteric Ligandsuccinate_off
15.00Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
15.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
15.00Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
15.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
15.00Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
15.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
15.00Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
14.81Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
14.81Single6W25SHU91196W25-MC4-SHU9119-Ca
14.81Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
14.81Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
14.81Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
14.71Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
14.71Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
14.71Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
14.29Single4NTJAZD12834NTJ-P2Y12-AZD1283
14.29Single5IUAQ274563485IUA-A2A-Q27456348-Na
14.29Single5MZPCaffeine5MZP-A2A-Caffeine-Na
14.29Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
14.29Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
14.29Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
14.29Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
14.29Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
14.29Single6LPLZM2413856LPL-A2A-ZM241385-Na
14.29Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
14.29Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
14.29Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
14.29Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
14.29Single6S0QZM2413856S0Q-A2A-ZM241385
14.29Single6WQAZM2413856WQA-A2A-ZM241385-Na
14.29Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29Single7RM5ZM2413857RM5-A2A-ZM241385-Na
14.29Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
14.29Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
14.29Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
14.29Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
14.29Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single8FYNZM2413858FYN-A2A-ZM241385-Na
14.29Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
14.29Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
14.29Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
14.29Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
14.29Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
14.29Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
14.29Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
14.29Consensusep_offOrthosteric Ligandep4_off
14.29Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
14.29Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
14.29Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
14.29Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.79Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
13.79Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
13.79Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
13.79Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
13.79Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.79Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
13.79Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
13.79Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
13.64Single5XRAAM115425XRA-CB1-AM11542
13.64Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
13.64Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
13.64Single6OS1TRV0266OS1-AT1-TRV026
13.64Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
13.64Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
13.64Single7PX4PSB-21137PX4-A2A-PSB-2113
13.64Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
13.64Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
13.64Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
13.64Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
13.64Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
13.64Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
13.64Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
13.64Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
13.64Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
13.64Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
13.64Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
13.64Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
13.64Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
13.33Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
13.33Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
13.33Single6FJ3PTH6FJ3-PTH1-PTH
13.33Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
13.33Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
13.33Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
13.33Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
13.33Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
13.33Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single8PWNTheophylline8PWN-A2A-Theophylline
13.33Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
13.33Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
13.33Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
13.04Single4N4WSANT-14N4W-SMO-SANT-1
13.04Single5X33BIIL2605X33-BLT1-BIIL260
13.04Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
13.04Single6IIURamatroban6IIU-TP-Ramatroban
13.04Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
13.04Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
13.04Single6OS2TRV0266OS2-AT1-TRV026
13.04Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
13.04Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
13.04Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
13.04Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
13.04Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
13.04Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
13.04Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
13.04Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
13.04Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
13.04Consensuschemokine_offOrthosteric Ligandcxcr_off
13.04Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
13.04Consensuscxcr_offOrthosteric Ligandcxcr4_off
13.04Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
13.04Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
13.04Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
12.90Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
12.90Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
12.90Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
12.90Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
12.90Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
12.90Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.82Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
12.50Single3RFMCaffeine3RFM-A2A-Caffeine
12.50Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
12.50Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
12.50Single6LMLGlucagon6LML-Glucagon-Glucagon
12.50Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
12.50Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
12.50Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
12.50Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
12.50Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8A2OTheophylline8A2O-A2A-Theophylline-Na
12.50Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
12.50Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
12.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
12.00Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
12.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
12.00Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
12.00Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
12.00Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
11.76Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
11.76Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
11.76Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
11.76Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
11.54Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
11.54Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
11.54Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
11.43Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
11.11Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
11.11Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
11.11Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
11.11Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.11Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
11.11Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
11.11Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
11.11Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
11.11Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
11.11Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.11Consensusgo_class-b2Orthosteric Ligandgo_adhesion
11.11Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.11Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
11.11Consensussst_offOrthosteric Ligandsst2_off
10.81Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
10.71Single3OE0CVX153OE0-CXCR4-CVX15
10.71Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
10.71Single7XNACYN1548067XNA-SST2-CYN154806
10.71Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
10.71Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
10.71Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
10.71Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
10.53Single3PWHZM2413853PWH-A2A-ZM241385
10.53Single5ZKQABT-4915ZKQ-PAF-ABT-491
10.53Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
10.53Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
10.53Single7F8YDevazepide7F8Y-CCKA-Devazepide
10.53Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
10.53Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
10.53Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
10.53Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.53Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
10.53Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
10.53Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
10.53Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
10.53Consensusmglu_onOther Ligandmglu2_on mglu4_on
10.34Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
10.34Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
10.34Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
10.26Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
10.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
10.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
10.00Single6MH8ZM2413856MH8-A2A-ZM241385
10.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
10.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
10.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
10.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
10.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
10.00Single8K2WAMG4878K2W-CXCR3-AMG487
10.00Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
10.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
10.00Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
10.00Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
10.00Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
10.00Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
9.76Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
9.68Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
9.68Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
9.68Single7SK3CXCL127SK3-ACKR3-CXCL12
9.68Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
9.68Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
9.68Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
9.52Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
9.52Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
9.52Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
9.52Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
9.52Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.52Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.52Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.52Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
9.52Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.52Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.52Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
9.52Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
9.52Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
9.38Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
9.38Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
9.38Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
9.38Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
9.09Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
9.09Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
9.09Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
9.09Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
9.09Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
9.09Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
9.09Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
9.09Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
9.09Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
9.09Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
8.82Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
8.82Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
8.82Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Single5TZR-5TZR-FFA1 (GPR40)-MK8666
8.70Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
8.70Single7F1TMIP-1a7F1T-CCR5-MIP-1a
8.70Single7P2L4YI7P2L-mGlu5-4YI
8.70Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
8.70Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
8.70Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
8.70Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
8.70Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
8.57Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
8.33Single4PY02MeSATP4PY0-P2Y12-2MeSATP
8.33Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
8.33Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
8.33Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
8.33Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
8.33Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
8.33Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
8.33Consensusclass-b2_onOrthosteric Ligandadgrg_on
8.33Consensusclass-c_offOther Ligandgabab_off mglu_off
8.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
8.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
8.00Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
8.00Consensuscyslt_offOrthosteric Ligandcyslt2_off
7.89Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
7.89Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
7.69Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
7.69Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
7.69Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
7.69Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
7.69Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
7.69Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
7.41Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
7.32Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
7.14Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
7.14Single7SHEPI; PE7SHE-GPR158-PI; PE
7.14Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
6.90Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
6.90Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
6.67Single6W25Ca6W25-MC4-SHU9119-Ca
6.45Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
6.25Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
6.25Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
6.25Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
6.25Consensusclass-c_onOther Ligandgabab_on mglu_on
6.06Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.06Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
5.88Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.88Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
5.88Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
5.56Single6LI0GTPL98046LI0-GPR52-GTPL9804
5.56Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
5.56Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
5.56Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.41Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Single5L7IVismodegib5L7I-SMO-Vismodegib
5.26Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
5.26Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
5.26Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
5.00Single4XNVBPTU4XNV-P2Y1-BPTU
5.00Single5U09Taranabant5U09-CB1-Taranabant
5.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
5.00Single7WV9ZCZ0117WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
5.00Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Consensuscb1_on_alloOther Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
5.00Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
5.00Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
5.00Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.76Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
4.76Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
4.76Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
4.76Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
4.76Single8IYXYL-3658IYX-GPR34-YL-365
4.76Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.76Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
4.35Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.35Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
4.35Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
4.35Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.35Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.17Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
4.17Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
4.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
4.00Single4XESNeurotensin4XES-NTS1-Neurotensin
4.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
4.00Single7SHEPI; PE7SHE-GPR158-PI; PE
4.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
4.00Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
4.00Consensusnts_offOrthosteric Ligandnts1_off
3.85Single4BUONeurotensin4BUO-NTS1-Neurotensin
3.85Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
3.85Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
3.85Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.70Single6KNMJN241-96KNM-Apelin-JN241-9
3.70Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Consensusgs_class-b2Orthosteric Ligandgs_adgr
3.57Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
3.57Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
3.57Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
3.57Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
3.45Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.45Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.23Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
2.86Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.86Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
2.78Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.78Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.78Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.70Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.63Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.63Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.56Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.56Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.44Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.33Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.27Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.27Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.17Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 5WIV
Class A
SubFamily Amine
Type Dopamine
SubType D4
Species Homo sapiens
Ligand Nemonapride
Other Ligand(s) Na
Protein Partners -
PDB Resolution 2.14
Date 2017-10-18
D.O.I. 10.1126/science.aan5468
Net Summary
Imin 3.53
Number of Linked Nodes 254
Number of Links 283
Number of Hubs 34
Number of Links mediated by Hubs 143
Number of Communities 9
Number of Nodes involved in Communities 59
Number of Links involved in Communities 76
Path Summary
Number Of Nodes in MetaPath 51
Number Of Links MetaPath 50
Number of Shortest Paths 56586
Length Of Smallest Path 3
Average Path Length 16.3166
Length of Longest Path 31
Minimum Path Strength 1.19
Average Path Strength 6.94384
Maximum Path Strength 18.5367
Minimum Path Correlation 0.7
Average Path Correlation 0.930296
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4
Average % Of Corr. Nodes 47.378
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 39.4057
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeAQD
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeAQD
NameNemonapride
SynonymsN-[(2R,3R)-1-benzyl-2-methylpyrrolidin-3-yl]-5-chloro-2-methoxy-4-(methylamino)benzamide
Identifier5-chloranyl-2-methoxy-4-(methylamino)-~{N}-[(2~{R},3~{R})-2-methyl-1-(phenylmethyl)pyrrolidin-3-yl]benzamide
FormulaC21 H26 Cl N3 O2
Molecular Weight387.903
SMILESC[C@@H]1[C@@H](CCN1Cc2ccccc2)NC(=O)c3cc(c(cc3OC)NC)Cl
PubChem156333
Formal Charge0
Total Atoms53
Total Chiral Atoms2
Total Bonds55
Total Aromatic Bonds12

CodeNA
PDB ResiduesI:I:?1
Environment DetailsOpen EMBL-EBI Page
CodeNA
NameSODIUM ION
Synonyms
Identifiersodium(+1) cation
FormulaNa
Molecular Weight22.99
SMILES[Na+]
PubChem
Formal Charge1
Total Atoms1
Total Chiral Atoms0
Total Bonds0
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP21917
Sequence
>5WIV_Chain_R
GQGAAALVG GVLLIGAVL AGNSLVCVS VATERALQT PTNSFIVSL 
AAADLLLAL LVLPLFVYS EVQGGAWLL SPRLCDALM AMDVMLCTA 
SIFNLCAIS VDRFVAVAV PLRYNRQGG SRRQLLLIG ATWLLSAAV 
AAPVLCGLN DPAVCRLED RDYVVYSSV CSFFLPCPL MLLLYWATF 
RGLQRWEVA RRAKITGRE RKAMRVLPV VVGAFLLCW TPFFVVHIT 
QALCPACSV PPRLVSAVT WLGYVNSAL NPVIYTVFN AEFRNVFRK 
ALR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
d4_off_allo5WIV-D4-Nemonapride-Na

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7LD4ANucleotideAdenosineA1Homo sapiensAdenosine-Gi2/&β;1/&γ;23.32021-09-0810.1038/s41586-021-03897-2
3D4SAAmineAdrenergicβ2Homo sapiensTimolol Maleate--2.82008-06-1710.1016/j.str.2008.05.001
5WIUAAmineDopamineD4Homo sapiensNemonapride--1.962017-10-1810.1126/science.aan5468
6IQLAAmineDopamineD4Mus musculusL745870--3.52019-12-0410.7554/eLife.48822
8IRUAAmineDopamineD4Homo sapiensRotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;23.22023-06-0710.1038/s41422-023-00808-0
8ID4ALipidFree fatty acidFFA4 (GPR120)Homo sapiensLinoleic acid-Gi1/&β;1/&γ;23.12023-03-1510.1126/science.add6220
6BD4FProteinFrizzledFZD4Homo sapiens---2.42018-08-2210.1038/s41586-018-0447-x
8JD4CAminoacidMetabotropic glutamatemGlu2; mGlu4Homo sapiensGlutamate--2.92023-06-2110.1038/s41422-023-00830-2
7TD4ALipidLysophospholipid (S1P)S1P1Homo sapiensSiponimod-Gi1/&β;1/&γ;22.62022-02-0910.1038/s41467-022-28417-2




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Download 5WIV.zip



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