Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:I26 3.5625429
2A:A:L30 3.9075425
3A:A:L41 4.885415
4A:A:L43 4.312517
5A:A:L44 8.865419
6A:A:L46 5.6925418
7A:A:S51 3.29419
8A:A:K53 5.576519
9A:A:F56 8.77667617
10A:A:F212 4.94833619
11A:A:F219 5.40857718
12A:A:H220 11.0475417
13A:A:M221 4.498518
14A:A:F222 9.61517
15A:A:K233 5.388519
16A:A:W234 7.6975419
17A:A:F238 8.30833619
18A:A:I244 4.364518
19A:A:I245 3.968517
20A:A:F246 6.962519
21A:A:V247 5.905417
22A:A:Y253 8.5675408
23A:A:R265 7.67489
24A:A:L270 5.072516
25A:A:F273 6.78719
26A:A:I276 3.614518
27A:A:W277 8.21143716
28A:A:W281 7.75571715
29A:A:L282 5.346519
30A:A:L289 4.43519
31A:A:F290 5.58778919
32A:A:L291 3.67618
33A:A:I308 5.774517
34A:A:Y311 3.37406
35A:A:F312 3.21286718
36A:A:Y339 4.3425413
37A:A:F340 9.19517
38A:A:I341 4.64418
39A:A:R342 6.96514
40A:A:F345 5.39333618
41A:A:C359 3.754515
42A:A:Y360 8.26833618
43A:A:F363 9.535415
44A:A:T364 6.576519
45A:A:N371 10.2375419
46A:A:R374 7.1075414
47A:A:I375 4.0575419
48A:A:F376 4.01818
49A:A:D381 7.7275418
50A:A:I383 3.6925418
51A:A:N387 4.1525418
52A:A:L388 3.86618
53A:A:E390 6.485414
54A:A:Y391 6.015614
55A:A:L393 5.5875408
56B:B:V40 4.922543
57B:B:I43 4.0725403
58B:B:M45 3.82534
59B:B:L51 7.565429
60B:B:H54 6.885629
61B:B:I58 5.918529
62B:B:Y59 9.354518
63B:B:M61 3.18571726
64B:B:W63 5.1725827
65B:B:L70 5.646525
66B:B:V71 3.635418
67B:B:S72 4.932529
68B:B:Q75 6.9925419
69B:B:L79 4.974517
70B:B:I80 5.826528
71B:B:I81 4.01617
72B:B:W82 7.71857729
73B:B:N88 6.154577
74B:B:K89 7.09143729
75B:B:H91 5.2875415
76B:B:I93 6.1475417
77B:B:L95 5.6075418
78B:B:W99 8.20125819
79B:B:V100 4.3875419
80B:B:M101 4.185419
81B:B:Y105 4.72816
82B:B:Y111 4.46614
83B:B:V112 3.7575418
84B:B:A113 2.8425419
85B:B:C114 4.64418
86B:B:L117 4.41619
87B:B:C121 3.07333618
88B:B:I123 4.36616
89B:B:Y124 4.54616
90B:B:L126 3.8125415
91B:B:T128 4.326553
92B:B:V133 6.1414
93B:B:L139 6.1175409
94B:B:H142 6.79286719
95B:B:Y145 6.22143718
96B:B:C149 4.178518
97B:B:F151 5.145619
98B:B:L152 3.5975403
99B:B:I157 4.33167617
100B:B:V158 6.02415
101B:B:T159 5.14419
102B:B:S161 7.4575419
103B:B:D163 8.916519
104B:B:L168 3.948516
105B:B:W169 8.24571718
106B:B:I171 4.2225416
107B:B:T173 4.8454115
108B:B:T178 5.2625414
109B:B:F180 9.10833617
110B:B:H183 7.03719
111B:B:V187 4.702519
112B:B:L190 5.6125415
113B:B:L192 3.675415
114B:B:A193 3.46414
115B:B:F199 7.94667619
116B:B:S201 4.304519
117B:B:G202 2.6925416
118B:B:D205 6.685419
119B:B:S207 4.8225415
120B:B:K209 8.032516
121B:B:W211 9.11167618
122B:B:R219 5.695415
123B:B:Q220 8.2725417
124B:B:F222 8.426518
125B:B:H225 7.01875819
126B:B:D228 6.9419
127B:B:I229 5.23417
128B:B:I232 4.74518
129B:B:F234 4.998515
130B:B:F235 6.47625816
131B:B:P236 6.7375417
132B:B:F241 6.1325816
133B:B:T243 3.98167618
134B:B:G244 2.7325415
135B:B:S245 6.585419
136B:B:D246 4.6725409
137B:B:D247 7.9425419
138B:B:T249 5.63416
139B:B:C250 3.515418
140B:B:F253 5.765616
141B:B:L255 5.4825416
142B:B:Y264 6.162515
143B:B:C271 5.3875415
144B:B:V276 4.0925406
145B:B:F278 4.54857717
146B:B:S281 4.11449
147B:B:G282 3.74419
148B:B:R283 5.81649
149B:B:L285 3.822516
150B:B:A287 2.7875406
151B:B:G288 1.8925437
152B:B:Y289 7.24617
153B:B:D290 6.7625416
154B:B:C294 3.678535
155B:B:N295 6.79616
156B:B:W297 6.262518
157B:B:R304 7.7725415
158B:B:V307 2.56413
159B:B:H311 9.606539
160B:B:R314 10.6417618
161B:B:V315 4.0475437
162B:B:L318 4.9175436
163B:B:T321 6.584527
164B:B:T329 4.65538
165B:B:G330 3.21405
166B:B:S331 8.2439
167B:B:W332 13.8714719
168B:B:D333 9.3225439
169B:B:F335 5.27404
170B:B:L336 3.93627
171B:B:K337 7.82436
172B:B:I338 4.86425
173B:B:W339 7.62429739
174G:G:Y40 9.045416
175G:G:D48 5.482549
176G:G:L51 3.695646
177R:R:S42 5.035416
178R:R:F43 4.235416
179R:R:L44 7.82464
180R:R:R46 9.1875466
181R:R:Y95 6.2415
182R:R:L101 3.885414
183R:R:V105 4.305615
184R:R:Y109 6.47429717
185R:R:L117 6.335406
186R:R:L119 4.3075417
187R:R:F127 4.978516
188R:R:P136 3.44416
189R:R:V139 3.98407
190R:R:Y140 5.79571717
191R:R:H143 7.885419
192R:R:L144 3.56167619
193R:R:D148 4.888519
194R:R:F151 5.565617
195R:R:V152 4.848516
196R:R:L155 4.43518
197R:R:F157 4.93416
198R:R:Y161 6.55333615
199R:R:Y162 6.81857715
200R:R:S166 5.2275414
201R:R:W168 6.51571719
202R:R:L174 3.445415
203R:R:C175 5.3875419
204R:R:F182 7.185616
205R:R:Y183 6.19415
206R:R:Y187 7.796518
207R:R:I190 4.176517
208R:R:L191 5.5775415
209R:R:L192 3.8275417
210R:R:M193 6.01518
211R:R:R200 7.56619
212R:R:F201 5.575408
213R:R:V204 3.835418
214R:R:W213 5.67754123
215R:R:R214 5.65833617
216R:R:W227 4.9275419
217R:R:L237 5.0125414
218R:R:Q242 6.8875414
219R:R:V246 4.77513
220R:R:I251 5.365612
221R:R:T253 5.335413
222R:R:H255 6.702514
223R:R:L262 4.4725413
224R:R:Y267 6.01614
225R:R:Y270 10.265415
226R:R:F271 8.63615
227R:R:F274 7.8075415
228R:R:F278 5.454516
229R:R:F279 6.47718
230R:R:P282 3.8625419
231R:R:L283 3.9925416
232R:R:Y290 5.11571718
233R:R:L297 3.418518
234R:R:K308 6.41833616
235R:R:S315 3.9475417
236R:R:V318 5.2875418
237R:R:F322 3.355619
238R:R:F326 5.11857719
239R:R:T329 4.39406
240R:R:N330 10.5775408
241R:R:L333 6.3425415
242R:R:H336 9.07414
243R:R:Y337 8.748515
244R:R:L340 2.715403
245R:R:E347 4.9512
246R:R:Y350 8.73714714
247R:R:F351 7.69501
248R:R:Y353 8.856505
249R:R:V357 4.285416
250R:R:C364 3.548518
251R:R:P368 5.5175419
252R:R:I370 4.28417
253R:R:Y371 4.75125819
254R:R:Y372 4.64816
255R:R:Y373 4.0325417
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:F238 A:A:L44 33.063915.83YesYes199
2A:A:L44 A:A:L46 48.876511.07YesYes198
3A:A:G47 A:A:L46 1001.71NoYes198
4A:A:F290 A:A:V247 15.27753.93YesYes197
5A:A:D378 A:A:Y360 15.840214.94NoYes078
6A:A:D381 A:A:Y360 15.60476.9YesYes188
7A:A:D381 R:R:K308 15.47658.3YesYes186
8A:A:G47 A:A:K53 92.22353.49NoYes199
9R:R:K308 R:R:L297 13.81954.23YesYes168
10A:A:K53 A:A:L45 84.50248.46YesNo198
11A:A:L45 A:A:M221 56.3647.07NoYes188
12A:A:L43 A:A:M221 28.2162.83YesYes178
13A:A:F219 A:A:L43 56.90564.87YesYes187
14A:A:I245 A:A:L45 28.17682.85YesNo178
15A:A:I245 A:A:L43 28.42457.14YesYes177
16A:A:F212 A:A:M221 28.2712.49YesYes198
17A:A:F212 A:A:F219 28.530718.22YesYes198
18A:A:F219 A:A:L41 85.05733.65YesYes185
19A:A:I383 A:A:L41 85.00874.28YesYes185
20A:A:I235 A:A:L44 16.46342.85NoYes199
21B:B:C294 B:B:G288 17.63931.96YesYes357
22B:B:G288 B:B:T274 26.85211.82YesNo078
23B:B:R314 B:B:T274 27.032810.35YesNo088
24A:A:W281 B:B:R314 26.96267YesYes158
25A:A:N279 A:A:W281 49.72333.39NoYes185
26A:A:I235 A:A:N279 16.39864.25NoNo198
27A:A:I276 A:A:L46 29.52425.71YesYes188
28A:A:L282 A:A:N279 33.50069.61YesNo198
29A:A:I276 A:A:L282 17.0342.85YesYes189
30A:A:F345 A:A:L270 14.611712.18YesYes186
31A:A:F246 A:A:I276 13.50293.77YesYes198
32B:B:C271 B:B:Y289 20.32144.03YesYes157
33A:A:I383 A:A:N387 85.09444.25YesYes188
34A:A:N387 R:R:A203 40.38574.69YesNo188
35A:A:N387 R:R:R214 44.55462.41YesYes187
36A:A:Y391 R:R:A203 40.35142.67YesNo148
37A:A:Y391 R:R:R214 40.37745.14YesYes147
38A:A:Y391 R:R:R200 74.570412.35YesYes149
39R:R:R200 R:R:Y371 74.97916.17YesYes199
40R:R:I293 R:R:L297 12.11782.85NoYes188
41B:B:I273 B:B:Y289 11.80646.04NoYes167
42R:R:I293 R:R:Y290 12.01713.63NoYes188
43R:R:F319 R:R:Y290 11.0056.19NoYes088
44R:R:F279 R:R:L283 10.6882.44YesYes186
45R:R:F279 R:R:N330 23.381222.96YesYes088
46R:R:N330 R:R:S275 18.25265.96YesNo085
47R:R:L333 R:R:S275 17.97823YesNo055
48R:R:M193 R:R:Y371 46.92565.99YesYes189
49R:R:F322 R:R:M193 12.05513.73YesYes198
50R:R:F326 R:R:M193 34.82484.98YesYes198
51R:R:F274 R:R:Y270 14.64487.22YesYes155
52R:R:F274 R:R:Y187 10.352611.35YesYes158
53R:R:F326 R:R:M186 22.88972.49YesNo097
54R:R:L144 R:R:Y371 25.53082.34YesYes199
55R:R:D148 R:R:L144 25.46922.71YesYes199
56R:R:C364 R:R:D148 25.27834.67YesYes189
57R:R:C364 R:R:F151 19.42322.79YesYes187
58R:R:F151 R:R:F182 28.64212.86YesYes176
59R:R:F151 R:R:M186 19.29964.98YesNo077
60R:R:L333 R:R:Y337 11.79084.69YesYes155
61R:R:L237 R:R:Y267 11.09822.34YesYes144
62R:R:V105 R:R:Y109 10.5952.52YesYes157
63R:R:F182 R:R:K158 14.70458.69YesNo066
64R:R:C175 R:R:T243 12.28943.38YesNo094
65A:A:I244 A:A:L282 16.71064.28YesYes189
66A:A:W281 B:B:D290 21.40997.82YesYes156
67B:B:C271 B:B:D290 21.13054.67YesYes156
68A:A:I244 A:A:L46 21.72374.28YesYes188
69A:A:F238 B:B:L117 13.82592.44YesYes199
70B:B:G244 B:B:I273 11.44255.29YesNo156
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9D4Z
Class A
SubFamily Peptide
Type Proteinase Activated
SubType PAR1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1L-Gs-CtGq)/Beta1/Gamma2
PDB Resolution 2.74
Date 2025-05-07
D.O.I. doi.org/10.1038/s41467-025-59138-x
Net Summary
Imin 1.75
Number of Linked Nodes 789
Number of Links 1170
Number of Hubs 255
Number of Links mediated by Hubs 870
Number of Communities 12
Number of Nodes involved in Communities 377
Number of Links involved in Communities 651
Path Summary
Number Of Nodes in MetaPath 71
Number Of Links MetaPath 70
Number of Shortest Paths 13221638
Length Of Smallest Path 3
Average Path Length 30.3378
Length of Longest Path 46
Minimum Path Strength 1.39
Average Path Strength 5.76256
Maximum Path Strength 28.42
Minimum Path Correlation 0.7
Average Path Correlation 0.996118
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.0303
Average % Of Corr. Nodes 31.5871
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 68.6611
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• G protein-coupled receptor-like
SCOP2Family Identifier• G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9D4Z_Chain_A
EKAEKILDR LLLLGGESG KSTGIEFKV NFHMFDVGR KWIQCFNDV 
TAIIFVVSS YNRLQEALN FKSIWNNRW LRTISVILF LNKQDLLAE 
KVLAGKSKI EDYFPEFAR YTTPEEDPR VTRAKYFIR EFISTASGD 
GRHCYPHFT CAVDTENRR FNDCDIIML RYLSADAVR SMDRNREGE 
KARELKTFI TIYPDLQDD DKVDIAIKL QNENV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9D4Z_Chain_B
DPVGRIQMR TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW 
DSYTTNKVH AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK 
TREGNVRVS RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE 
TGQQTTTFT GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM 
CRQTFTGHE SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM 
TYSHDNIIC GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV 
LAGHDNRVS CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9D4Z_Chain_G
AADLMAYCE AHAKEDPLL TPVPAS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP25116
Sequence
>9D4Z_Chain_R
SFLLRNAFI SEDASGYLT SSWLTLFVP SVYTGVFVV SLPLNIMAI 
VVFILKMKV KKPAVVYML HLATADVLF VSVLPFKIS YYFSGSDWQ 
FGSELCRFV TAAFYCNMY ASILLMTVI SIDRFLAVV YPMQSLSWR 
TLGRASFTC LAIWALAIA GVVPLLLKE QTIQVPGLN ITTCHDVLN 
ETLLEGYYA YYFSAFSAV FFFVPLIIS TVCYVSIIR CLSSSAVAN 
RSKKSRALF LSAAVFCIF IICFGPTNV LLIAHYSFL SHTSTTEAA 
YFAYLLCVC VSSISCCID PLIYYYASS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
3VW7APeptideProteinase ActivatedPAR1Homo sapiens-Vorapaxar; Na-2.22012-12-12doi.org/10.1038/nature11701
8XORAPeptideProteinase ActivatedPAR1Homo sapiens--chim(NtGi1-Gs-CtGq)/β1/γ232024-09-18doi.org/10.1038/s41422-024-00997-2
8XOR (No Gprot) APeptideProteinase ActivatedPAR1Homo sapiens--32024-09-18doi.org/10.1038/s41422-024-00997-2
8XOSAPeptideProteinase ActivatedPAR1Homo sapiens--Gi1/β1/γ23.22024-09-18doi.org/10.1038/s41422-024-00997-2
8XOS (No Gprot) APeptideProteinase ActivatedPAR1Homo sapiens--3.22024-09-18doi.org/10.1038/s41422-024-00997-2
9D4ZAPeptideProteinase ActivatedPAR1Homo sapiens--chim(NtGi1L-Gs-CtGq)/β1/γ22.742025-05-07doi.org/10.1038/s41467-025-59138-x
9D4Z (No Gprot) APeptideProteinase ActivatedPAR1Homo sapiens--2.742025-05-07doi.org/10.1038/s41467-025-59138-x




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9D4Z.zip



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