psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H255	R:R:S42	6.97	No	No	0	4	6
2	R:R:S42	R:R:Y350	7.63	No	Yes	0	6	4
3	R:R:A92	R:R:F43	4.16	No	No	0	7	6
4	R:R:F43	R:R:Y350	7.22	No	Yes	0	6	4
5	R:R:L44	R:R:R46	9.72	Yes	Yes	4	4	6
6	R:R:E260	R:R:L44	9.28	No	Yes	4	2	4
7	R:R:L263	R:R:L44	8.3	No	Yes	0	4	4
8	R:R:E264	R:R:L44	3.98	No	Yes	4	4	4
9	R:R:A86	R:R:L45	4.73	No	No	0	5	6
10	R:R:I244	R:R:L45	4.28	No	No	0	2	6
11	R:R:F87	R:R:R46	4.28	No	Yes	0	2	6
12	R:R:E260	R:R:R46	16.28	No	Yes	4	2	6
13	R:R:R46	R:R:T343	6.47	Yes	No	0	6	6
14	R:R:I88	R:R:V246	4.61	No	Yes	0	4	3
15	R:R:E347	R:R:S89	8.62	No	No	0	2	6
16	R:R:A92	R:R:E347	7.54	No	No	0	7	2
17	R:R:G94	R:R:S93	3.71	No	No	0	4	2
18	R:R:A348	R:R:Y95	4	No	No	0	1	5
19	R:R:F351	R:R:Y95	16.5	Yes	No	0	1	5
20	R:R:L96	R:R:S166	9.01	No	Yes	0	5	4
21	R:R:F351	R:R:S98	3.96	Yes	No	0	1	7
22	R:R:F351	R:R:W100	7.02	Yes	No	0	1	5
23	R:R:L101	R:R:V105	4.47	No	Yes	1	4	5
24	R:R:L101	R:R:Y162	5.86	No	Yes	1	4	5
25	R:R:F104	R:R:V108	7.87	No	No	0	5	5
26	R:R:P106	R:R:V105	3.53	No	Yes	1	6	5
27	R:R:V105	R:R:Y162	3.79	Yes	Yes	1	5	5
28	R:R:C358	R:R:V105	8.54	No	Yes	0	5	5
29	R:R:P106	R:R:Y162	4.17	No	Yes	1	6	5
30	R:R:F163	R:R:P106	17.34	No	No	0	4	6
31	R:R:C358	R:R:V108	6.83	No	No	0	5	5
32	R:R:L155	R:R:Y109	8.21	No	Yes	0	8	7
33	R:R:I159	R:R:Y109	3.63	No	Yes	0	7	7
34	R:R:F182	R:R:Y109	7.22	Yes	Yes	0	6	7
35	R:R:C358	R:R:Y109	16.13	No	Yes	0	5	7
36	R:R:S361	R:R:Y109	5.09	No	Yes	0	7	7
37	R:R:I159	R:R:T110	7.6	No	No	0	7	4
38	R:R:S361	R:R:V112	9.7	No	No	0	7	7
39	R:R:F113	R:R:L117	13.4	No	Yes	0	7	6
40	R:R:F113	R:R:L155	3.65	No	No	0	7	8
41	R:R:F113	R:R:P156	4.33	No	No	0	7	9
42	R:R:C365	R:R:V115	8.54	No	No	0	8	5
43	R:R:N120	R:R:S116	4.47	No	No	0	9	8
44	R:R:S116	R:R:V152	6.46	No	No	0	8	6
45	R:R:L117	R:R:V152	7.45	Yes	No	0	6	6
46	R:R:L119	R:R:L369	4.15	Yes	No	7	7	6
47	R:R:L119	R:R:Y373	8.21	Yes	No	0	7	7
48	R:R:D148	R:R:N120	9.42	No	No	0	9	9
49	R:R:N120	R:R:P368	11.4	No	No	0	9	9
50	R:R:M122	R:R:Y373	3.59	No	No	0	5	7
51	R:R:A123	R:R:Y372	4	No	Yes	0	8	6
52	R:R:F127	R:R:V126	5.24	No	No	0	6	7
53	R:R:F127	R:R:M141	4.98	No	No	8	6	8
54	R:R:F127	R:R:Y372	9.28	No	Yes	8	6	6
55	R:R:I128	R:R:L129	4.28	No	No	0	4	4
56	R:R:I128	R:R:L142	4.28	No	No	0	4	6
57	R:R:M131	R:R:V138	4.56	No	No	0	5	7
58	R:R:V133	R:R:V138	6.41	No	No	0	6	7
59	R:R:P136	R:R:R214	5.76	No	No	0	6	7
60	R:R:A219	R:R:V139	5.09	No	No	0	7	7
61	R:R:S220	R:R:V139	4.85	No	No	0	3	7
62	R:R:V195	R:R:Y140	8.83	No	Yes	0	7	7
63	R:R:I196	R:R:Y140	3.63	No	Yes	0	9	7
64	R:R:D199	R:R:Y140	12.64	No	Yes	0	8	7
65	R:R:A219	R:R:Y140	6.67	No	Yes	0	7	7
66	R:R:C223	R:R:Y140	4.03	No	Yes	0	7	7
67	R:R:M141	R:R:Y372	7.18	No	Yes	8	8	6
68	R:R:H143	R:R:L192	5.14	No	No	0	9	7
69	R:R:C223	R:R:H143	16.22	No	No	0	7	9
70	R:R:H143	R:R:W227	7.41	No	Yes	0	9	9
71	R:R:L144	R:R:L192	4.15	No	No	0	9	7
72	R:R:L144	R:R:M193	5.65	No	Yes	0	9	8
73	R:R:L144	R:R:Y372	3.52	No	Yes	0	9	6
74	R:R:A145	R:R:Y372	4	No	Yes	0	8	6
75	R:R:D148	R:R:S189	4.42	No	No	0	9	9
76	R:R:C364	R:R:D148	4.67	No	No	0	8	9
77	R:R:L150	R:R:N185	6.87	No	No	0	6	8
78	R:R:F151	R:R:V152	3.93	Yes	No	0	7	6
79	R:R:F151	R:R:L155	4.87	Yes	No	0	7	8
80	R:R:F151	R:R:F182	12.86	Yes	Yes	0	7	6
81	R:R:F151	R:R:M186	4.98	Yes	No	0	7	7
82	R:R:F151	R:R:S361	3.96	Yes	No	0	7	7
83	R:R:F157	R:R:W168	4.01	Yes	Yes	1	6	9
84	R:R:F157	R:R:F170	4.29	Yes	No	1	6	7
85	R:R:F157	R:R:L174	4.87	Yes	No	0	6	5
86	R:R:F157	R:R:V178	6.55	Yes	No	0	6	5
87	R:R:K158	R:R:Y162	7.17	No	Yes	0	6	5
88	R:R:F182	R:R:K158	8.69	Yes	No	0	6	6
89	R:R:F170	R:R:S160	5.28	No	No	0	7	4
90	R:R:Y161	R:R:Y162	12.91	Yes	Yes	1	5	5
91	R:R:S166	R:R:Y161	5.09	Yes	Yes	0	4	5
92	R:R:W168	R:R:Y161	5.79	Yes	Yes	1	9	5
93	R:R:D256	R:R:Y161	10.34	No	Yes	1	4	5
94	R:R:D256	R:R:Y162	11.49	No	Yes	1	4	5
95	R:R:G165	R:R:S166	3.71	No	Yes	0	4	4
96	R:R:D167	R:R:I251	8.4	No	Yes	0	4	2
97	R:R:F170	R:R:W168	11.02	No	Yes	1	7	9
98	R:R:G171	R:R:W168	4.22	No	Yes	0	8	9
99	R:R:C175	R:R:W168	7.84	No	Yes	1	9	9
100	R:R:C254	R:R:W168	10.45	No	Yes	1	9	9
101	R:R:R176	R:R:S172	5.27	No	No	0	7	2
102	R:R:S172	R:R:T243	6.4	No	No	0	2	4
103	R:R:F177	R:R:L174	3.65	No	No	0	4	5
104	R:R:C175	R:R:C254	7.28	No	No	1	9	9
105	R:R:E241	R:R:R176	5.82	No	No	0	4	7
106	R:R:Q242	R:R:T179	11.34	No	No	6	4	5
107	R:R:H255	R:R:T179	12.32	No	No	6	4	5
108	R:R:A180	R:R:L238	6.3	No	No	0	6	4
109	R:R:F182	R:R:Y183	9.28	Yes	No	0	6	5
110	R:R:F271	R:R:Y183	6.19	Yes	No	0	5	5
111	R:R:Y183	R:R:Y353	6.95	No	Yes	0	5	5
112	R:R:C184	R:R:V234	10.25	No	No	0	5	6
113	R:R:N185	R:R:W227	4.52	No	Yes	0	8	9
114	R:R:M186	R:R:Y187	9.58	No	Yes	0	7	8
115	R:R:F274	R:R:Y187	11.35	Yes	Yes	3	5	8
116	R:R:F278	R:R:Y187	5.16	Yes	Yes	3	6	8
117	R:R:N330	R:R:Y187	10.47	No	Yes	0	8	8
118	R:R:A188	R:R:W227	5.19	No	Yes	0	7	9
119	R:R:F326	R:R:I190	10.05	Yes	No	0	9	7
120	R:R:I226	R:R:L191	9.99	No	No	0	7	5
121	R:R:F278	R:R:L191	6.09	Yes	No	0	6	5
122	R:R:F322	R:R:M193	3.73	No	Yes	2	9	8
123	R:R:F326	R:R:M193	4.98	Yes	Yes	2	9	8
124	R:R:D367	R:R:M193	9.7	No	Yes	2	9	8
125	R:R:M193	R:R:Y371	5.99	Yes	Yes	2	8	9
126	R:R:P282	R:R:T194	5.25	No	No	0	9	7
127	R:R:I196	R:R:R200	3.76	No	Yes	2	9	9
128	R:R:I196	R:R:Y371	3.63	No	Yes	2	9	9
129	R:R:S197	R:R:S286	6.52	No	No	0	9	8
130	R:R:C289	R:R:S197	6.89	No	No	0	7	9
131	R:R:S197	R:R:Y290	3.82	No	Yes	0	9	8
132	R:R:R200	R:R:Y290	8.23	Yes	Yes	2	9	8
133	R:R:R200	R:R:V318	3.92	Yes	Yes	2	9	8
134	R:R:R200	R:R:Y371	6.17	Yes	Yes	2	9	9
135	R:R:F201	R:R:L202	3.65	Yes	No	0	8	6
136	R:R:F201	R:R:V205	9.18	Yes	No	0	8	7
137	R:R:C289	R:R:F201	4.19	No	Yes	0	7	8
138	R:R:F201	R:R:S292	5.28	Yes	No	0	8	3
139	R:R:L202	R:R:W213	5.69	No	Yes	0	6	3
140	R:R:A203	R:R:R214	6.91	No	No	0	8	7
141	R:R:L297	R:R:V204	4.47	No	No	0	8	8
142	R:R:V205	R:R:Y206	6.31	No	Yes	0	7	7
143	R:R:Q209	R:R:Y206	5.64	No	Yes	9	4	7
144	R:R:W213	R:R:Y206	5.79	Yes	Yes	9	3	7
145	R:R:Q209	R:R:W213	8.76	No	Yes	9	4	3
146	R:R:R214	R:R:S210	7.91	No	No	0	7	5
147	R:R:R218	R:R:T215	6.47	No	No	0	4	6
148	R:R:P236	R:R:V235	3.53	No	No	0	7	4
149	R:R:P236	R:R:Y266	6.95	No	No	0	7	4
150	R:R:P236	R:R:Y270	9.74	No	Yes	0	7	5
151	R:R:L237	R:R:Y270	11.72	No	Yes	3	4	5
152	R:R:F271	R:R:L237	3.65	Yes	No	3	5	4
153	R:R:K240	R:R:L262	5.64	No	No	0	4	3
154	R:R:K240	R:R:Y266	16.72	No	No	0	4	4
155	R:R:K240	R:R:Y267	14.33	No	No	0	4	4
156	R:R:H255	R:R:Q242	8.65	No	No	6	4	4
157	R:R:Q242	R:R:Y267	4.51	No	No	0	4	4
158	R:R:Q245	R:R:T252	5.67	No	No	0	1	5
159	R:R:P247	R:R:V246	3.53	No	Yes	0	1	3
160	R:R:I251	R:R:V246	6.14	Yes	Yes	5	2	3
161	R:R:T253	R:R:V246	4.76	No	Yes	5	3	3
162	R:R:V246	R:R:V257	4.81	Yes	No	5	3	3
163	R:R:I251	R:R:L249	7.14	Yes	No	0	2	4
164	R:R:I251	R:R:T253	4.56	Yes	No	5	2	3
165	R:R:T253	R:R:V257	9.52	No	No	5	3	3
166	R:R:L258	R:R:L263	4.15	No	No	0	5	4
167	R:R:L258	R:R:Y267	10.55	No	No	0	5	4
168	R:R:N259	R:R:T261	5.85	No	No	10	4	1
169	R:R:L262	R:R:N259	5.49	No	No	10	3	4
170	R:R:E260	R:R:E264	8.88	No	No	4	2	4
171	R:R:L262	R:R:T261	4.42	No	No	10	3	1
172	R:R:F271	R:R:Y270	12.38	Yes	Yes	3	5	5
173	R:R:F274	R:R:Y270	7.22	Yes	Yes	3	5	5
174	R:R:F271	R:R:Y337	23.73	Yes	No	0	5	5
175	R:R:F274	R:R:F278	9.65	Yes	Yes	3	5	6
176	R:R:N330	R:R:S275	5.96	No	No	0	8	5
177	R:R:I334	R:R:S275	6.19	No	No	0	5	5
178	R:R:F278	R:R:V277	3.93	Yes	No	0	6	4
179	R:R:F279	R:R:F280	7.5	No	No	0	8	5
180	R:R:F279	R:R:G327	4.52	No	No	0	8	5
181	R:R:F279	R:R:N330	22.96	No	No	0	8	8
182	R:R:P282	R:R:V281	3.53	No	No	0	9	5
183	R:R:F322	R:R:L283	4.87	No	No	0	9	6
184	R:R:I323	R:R:L283	5.71	No	No	0	5	6
185	R:R:F319	R:R:T287	9.08	No	No	0	8	4
186	R:R:I293	R:R:Y290	3.63	No	Yes	0	8	8
187	R:R:S315	R:R:Y290	5.09	No	Yes	0	7	8
188	R:R:V318	R:R:Y290	6.31	Yes	Yes	2	8	8
189	R:R:F319	R:R:Y290	6.19	No	Yes	0	8	8
190	R:R:I294	R:R:L312	5.71	No	No	0	4	5
191	R:R:K308	R:R:L297	4.23	No	No	0	6	8
192	R:R:K308	R:R:V302	4.55	No	No	0	6	3
193	R:R:K308	R:R:S306	7.65	No	No	0	6	2
194	R:R:I370	R:R:V318	4.61	Yes	Yes	2	7	8
195	R:R:V318	R:R:Y371	6.31	Yes	Yes	2	8	9
196	R:R:F319	R:R:I323	3.77	No	No	0	8	5
197	R:R:I321	R:R:I366	5.89	No	No	0	6	7
198	R:R:I321	R:R:I370	4.42	No	Yes	0	6	7
199	R:R:F322	R:R:F326	4.29	No	Yes	2	9	9
200	R:R:C325	R:R:F326	4.19	No	Yes	0	8	9
201	R:R:F326	R:R:S363	6.61	Yes	No	0	9	9
202	R:R:G327	R:R:P328	4.06	No	No	0	5	9
203	R:R:C356	R:R:T329	5.07	No	No	0	6	6
204	R:R:S360	R:R:T329	6.4	No	No	0	8	6
205	R:R:L333	R:R:Y337	4.69	No	No	0	5	5
206	R:R:L333	R:R:Y353	15.24	No	Yes	0	5	5
207	R:R:I334	R:R:S338	6.19	No	No	0	5	4
208	R:R:H336	R:R:Y337	9.8	Yes	No	0	4	5
209	R:R:H336	R:R:L340	3.86	Yes	No	0	4	3
210	R:R:H336	R:R:T346	4.11	Yes	No	0	4	1
211	R:R:H336	R:R:Y350	18.51	Yes	Yes	0	4	4
212	R:R:F339	R:R:S338	7.93	No	No	0	3	4
213	R:R:Y350	R:R:Y353	10.92	Yes	Yes	0	4	5
214	R:R:L354	R:R:Y350	11.72	No	Yes	0	4	4
215	R:R:F351	R:R:L355	8.53	Yes	No	0	1	5
216	R:R:V357	R:R:Y353	8.83	No	Yes	0	6	5
217	R:R:D367	R:R:S363	5.89	No	No	0	9	9
218	R:R:D367	R:R:Y371	5.75	No	Yes	2	9	9
219	R:R:P368	R:R:Y372	4.17	No	Yes	0	9	6
220	R:R:I370	R:R:Y371	4.84	Yes	Yes	2	7	9
221	R:R:C296	R:R:V204	3.42	No	No	0	5	8
222	R:R:C296	R:R:V205	3.42	No	No	0	5	7
223	R:R:A180	R:R:V234	3.39	No	No	0	6	6
224	R:R:I190	R:R:P282	3.39	No	No	0	7	9
225	R:R:C175	R:R:T243	3.38	No	No	0	9	4
226	R:R:K135	R:R:P136	3.35	No	No	0	7	6
227	R:R:L45	R:R:P247	3.28	No	No	0	6	1
228	R:R:L119	R:R:P368	3.28	Yes	No	0	7	9
229	R:R:C184	R:R:I231	3.27	No	No	0	5	3
230	R:R:C289	R:R:I198	3.27	No	No	0	7	6
231	R:R:S272	R:R:S338	3.26	No	No	0	4	4
232	R:R:S375	R:R:S376	3.26	No	No	0	7	5
233	R:R:A145	R:R:I124	3.25	No	No	0	8	7
234	R:R:A317	R:R:I370	3.25	No	Yes	0	4	7
235	R:R:V133	R:R:V139	3.21	No	No	0	6	7
236	R:R:T222	R:R:V195	3.17	No	No	0	5	7
237	R:R:T329	R:R:V357	3.17	No	No	0	6	6
238	R:R:C356	R:R:L332	3.17	No	No	0	6	5
239	R:R:T243	R:R:T252	3.14	No	No	0	4	5
240	R:R:I88	R:R:S93	3.1	No	No	0	4	2
241	R:R:I251	R:R:S166	3.1	Yes	Yes	0	2	4
242	R:R:I294	R:R:S315	3.1	No	No	0	4	7
243	R:R:K307	R:R:S309	3.06	No	No	0	4	4
244	R:R:K130	R:R:V126	3.04	No	No	0	5	7
245	R:R:F221	R:R:G217	3.01	No	No	0	2	4
246	R:R:F274	R:R:G233	3.01	Yes	No	0	5	5
247	R:R:L103	R:R:S107	3	No	No	0	4	5
248	R:R:L312	R:R:S298	3	No	No	0	5	4
249	R:R:L355	R:R:V105	2.98	No	Yes	0	5	5
250	R:R:L150	R:R:V149	2.98	No	No	0	6	7
251	R:R:L239	R:R:V235	2.98	No	No	0	4	4
252	R:R:L249	R:R:T97	2.95	No	No	0	4	5
253	R:R:L150	R:R:T146	2.95	No	No	0	6	5
254	R:R:I198	R:R:I285	2.94	No	No	0	6	6
255	R:R:K132	R:R:K134	2.87	No	No	0	6	5
256	R:R:I121	R:R:L117	2.85	No	Yes	0	4	6
257	R:R:P136	R:R:Y140	2.78	No	Yes	0	6	7
258	R:R:A181	R:R:F177	2.77	No	No	0	5	4
259	R:R:H342	R:R:T345	2.74	No	No	0	2	1
260	R:R:F163	R:R:S107	2.64	No	No	0	4	5
261	R:R:D91	R:R:E347	2.6	No	No	0	3	2
262	R:R:A147	R:R:W227	2.59	No	Yes	0	8	9
263	R:R:S212	R:R:W213	2.47	No	Yes	0	3	3
264	R:R:F278	R:R:L229	2.44	Yes	No	0	6	4
265	R:R:L314	R:R:R310	2.43	No	No	0	7	7
266	R:R:F87	R:R:N47	2.42	No	No	0	2	6
267	R:R:G111	R:R:V114	1.84	No	No	0	5	5
268	R:R:G165	R:R:T102	1.82	No	No	0	4	3
269	R:R:G111	R:R:T110	1.82	No	No	0	5	4
270	R:R:A230	R:R:C184	1.81	No	No	0	8	5
271	R:R:A188	R:R:A230	1.79	No	No	0	7	8
272	R:R:G217	R:R:L216	1.71	No	No	0	4	2
273	R:R:A301	R:R:S299	1.71	No	No	0	3	4
274	R:R:A181	R:R:V154	1.7	No	No	0	5	6
275	R:R:L117	R:R:P118	1.64	Yes	No	0	6	4
276	R:R:C325	R:R:I324	1.64	No	No	0	8	6
277	R:R:S153	R:R:V154	1.62	No	No	0	6	6
278	R:R:S292	R:R:V288	1.62	No	No	0	3	4
279	R:R:S292	R:R:V291	1.62	No	No	0	3	3
280	R:R:S360	R:R:V359	1.62	No	No	0	8	7
281	R:R:A137	R:R:M141	1.61	No	No	0	7	8
282	R:R:C365	R:R:L119	1.59	No	Yes	7	8	7
283	R:R:C365	R:R:L369	1.59	No	No	7	8	6
284	R:R:A268	R:R:L340	1.58	No	No	0	3	3
285	R:R:A311	R:R:L297	1.58	No	No	0	7	8
286	R:R:A374	R:R:L314	1.58	No	No	0	6	7
287	R:R:A352	R:R:L332	1.58	No	No	0	5	5
288	R:R:T345	R:R:T346	1.57	No	No	0	1	1
289	R:R:A303	R:R:N304	1.56	No	No	0	3	4
290	R:R:I362	R:R:V112	1.54	No	No	0	4	7
291	R:R:I128	R:R:V133	1.54	No	No	0	4	6
292	R:R:I284	R:R:V288	1.54	No	No	0	3	4
293	R:R:L129	R:R:V125	1.49	No	No	0	4	3
294	R:R:N304	R:R:S300	1.49	No	No	0	4	6
295	R:R:D167	R:R:S164	1.47	No	No	0	4	4
296	R:R:L216	R:R:T215	1.47	No	No	0	2	6
297	R:R:G265	R:R:Y269	1.45	No	No	0	3	2
298	R:R:P207	R:R:Y206	1.39	No	Yes	0	8	7
299	R:R:H342	R:R:S341	1.39	No	No	0	2	3
300	R:R:M208	R:R:Q209	1.36	No	No	0	4	4
301	R:R:F221	R:R:S220	1.32	No	No	0	2	3
302	R:R:F313	R:R:S309	1.32	No	No	0	5	4
303	R:R:D167	R:R:Q169	1.31	No	No	0	4	2
304	R:R:D91	R:R:E90	1.3	No	No	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L44	7.82	4	4	4
2	R:R:R46	9.1875	4	4	6
3	R:R:V105	4.662	5	1	5
4	R:R:Y109	8.056	5	0	7
5	R:R:L117	6.335	4	0	6
6	R:R:L119	4.3075	4	7	7
7	R:R:Y140	6.43	6	0	7
8	R:R:F151	6.12	5	0	7
9	R:R:F157	4.93	4	1	6
10	R:R:Y161	8.5325	4	1	5
11	R:R:Y162	7.565	6	1	5
12	R:R:S166	5.2275	4	0	4
13	R:R:W168	7.22167	6	1	9
14	R:R:F182	9.5125	4	0	6
15	R:R:Y187	9.14	4	3	8
16	R:R:M193	6.01	5	2	8
17	R:R:R200	5.52	4	2	9
18	R:R:F201	5.575	4	0	8
19	R:R:Y206	4.7825	4	9	7
20	R:R:W213	5.6775	4	9	3
21	R:R:W227	4.9275	4	0	9
22	R:R:V246	4.77	5	5	3
23	R:R:I251	5.868	5	5	2
24	R:R:Y270	10.265	4	3	5
25	R:R:F271	11.4875	4	3	5
26	R:R:F274	7.8075	4	3	5
27	R:R:F278	5.454	5	3	6
28	R:R:Y290	5.545	6	2	8
29	R:R:V318	5.2875	4	2	8
30	R:R:F326	6.024	5	2	9
31	R:R:H336	9.07	4	0	4
32	R:R:Y350	11.2	5	0	4
33	R:R:F351	9.0025	4	0	1
34	R:R:Y353	10.485	4	0	5
35	R:R:I370	4.28	4	2	7
36	R:R:Y371	5.44833	6	2	9
37	R:R:Y372	5.35833	6	8	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S42	R:R:Y350	10.8705	7.63	No	Yes	0	6	4
2	R:R:H255	R:R:S42	10.0977	6.97	No	No	0	4	6
3	R:R:L258	R:R:Y267	18.16	10.55	No	No	0	5	4
4	R:R:L258	R:R:L263	16.1782	4.15	No	No	0	5	4
5	R:R:L263	R:R:L44	14.1735	8.3	No	Yes	0	4	4
6	R:R:I251	R:R:S166	14.9565	3.1	Yes	Yes	0	2	4
7	R:R:S166	R:R:Y161	18.262	5.09	Yes	Yes	0	4	5
8	R:R:Y161	R:R:Y162	33.4609	12.91	Yes	Yes	1	5	5
9	R:R:K158	R:R:Y162	40.5106	7.17	No	Yes	0	6	5
10	R:R:F182	R:R:K158	41.036	8.69	Yes	No	0	6	6
11	R:R:F182	R:R:Y183	47.2467	9.28	Yes	No	0	6	5
12	R:R:Y183	R:R:Y353	27.7068	6.95	No	Yes	0	5	5
13	R:R:Y350	R:R:Y353	21.4681	10.92	Yes	Yes	0	4	5
14	R:R:F351	R:R:L355	12.9288	8.53	Yes	No	0	1	5
15	R:R:L355	R:R:V105	15.4998	2.98	No	Yes	0	5	5
16	R:R:C358	R:R:V105	14.0944	8.54	No	Yes	0	5	5
17	R:R:C358	R:R:Y109	18.9379	16.13	No	Yes	0	5	7
18	R:R:F182	R:R:Y109	12.7018	7.22	Yes	Yes	0	6	7
19	R:R:F151	R:R:F182	71.3061	12.86	Yes	Yes	0	7	6
20	R:R:F151	R:R:S361	10.2813	3.96	Yes	No	0	7	7
21	R:R:F151	R:R:V152	99.0129	3.93	Yes	No	0	7	6
22	R:R:N120	R:R:P368	99.4389	11.4	No	No	0	9	9
23	R:R:N120	R:R:S116	99.898	4.47	No	No	0	9	8
24	R:R:S116	R:R:V152	100	6.46	No	No	0	8	6
25	R:R:P368	R:R:Y372	98.4671	4.17	No	Yes	0	9	6
26	R:R:L144	R:R:Y372	96.7659	3.52	No	Yes	0	9	6
27	R:R:L144	R:R:L192	25.4521	4.15	No	No	0	9	7
28	R:R:H143	R:R:L192	24.6997	5.14	No	No	0	9	7
29	R:R:C223	R:R:H143	17.808	16.22	No	No	0	7	9
30	R:R:C223	R:R:Y140	17.3362	4.03	No	Yes	0	7	7
31	R:R:A219	R:R:Y140	21.5752	6.67	No	Yes	0	7	7
32	R:R:A219	R:R:V139	20.1724	5.09	No	No	0	7	7
33	R:R:V133	R:R:V139	10.2099	3.21	No	No	0	6	7
34	R:R:L144	R:R:M193	73.0686	5.65	No	Yes	0	9	8
35	R:R:M193	R:R:Y371	64.9756	5.99	Yes	Yes	2	8	9
36	R:R:I196	R:R:Y371	16.6297	3.63	No	Yes	2	9	9
37	R:R:I196	R:R:Y140	19.7541	3.63	No	Yes	0	9	7
38	R:R:H143	R:R:W227	11.0057	7.41	No	Yes	0	9	9
39	R:R:F151	R:R:M186	23.9677	4.98	Yes	No	0	7	7
40	R:R:W168	R:R:Y161	16.6195	5.79	Yes	Yes	1	9	5
41	R:R:F271	R:R:Y183	21.3941	6.19	Yes	No	0	5	5
42	R:R:F271	R:R:Y270	15.8365	12.38	Yes	Yes	3	5	5
43	R:R:F274	R:R:Y270	12.4264	7.22	Yes	Yes	3	5	5
44	R:R:F274	R:R:Y187	12.485	11.35	Yes	Yes	3	5	8
45	R:R:K240	R:R:Y267	13.013	14.33	No	No	0	4	4
46	R:R:K240	R:R:Y266	17.78	16.72	No	No	0	4	4
47	R:R:P236	R:R:Y266	19.0374	6.95	No	No	0	7	4
48	R:R:P236	R:R:Y270	22.7128	9.74	No	Yes	0	7	5
49	R:R:M186	R:R:Y187	23.2458	9.58	No	Yes	0	7	8
50	R:R:R200	R:R:Y371	23.0597	6.17	Yes	Yes	2	9	9
51	R:R:R200	R:R:Y290	26.1178	8.23	Yes	Yes	2	9	8
52	R:R:S197	R:R:Y290	38.6615	3.82	No	Yes	0	9	8
53	R:R:V318	R:R:Y371	23.2484	6.31	Yes	Yes	2	8	9
54	R:R:V318	R:R:Y290	22.9449	6.31	Yes	Yes	2	8	8
55	R:R:C289	R:R:S197	35.9069	6.89	No	No	0	7	9
56	R:R:C289	R:R:F201	31.7367	4.19	No	Yes	0	7	8
57	R:R:F201	R:R:V205	17.4535	9.18	Yes	No	0	8	7
58	R:R:C296	R:R:V205	10.2354	3.42	No	No	0	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9D4Z_nogp

PDB Summary
PDB	9D4Z_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	278
Number of Links	304
Number of Hubs	37
Number of Links mediated by Hubs	142
Number of Communities	10
Number of Nodes involved in Communities	50
Number of Links involved in Communities	62

Path Summary
Number Of Nodes in MetaPath	59
Number Of Links MetaPath	58
Number of Shortest Paths	62803
Length Of Smallest Path	3
Average Path Length	16.1855
Length of Longest Path	34
Minimum Path Strength	1.39
Average Path Strength	6.70974
Maximum Path Strength	18.055
Minimum Path Correlation	0.7
Average Path Correlation	0.92488
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	45.2819
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.2835
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein alpha-subunit binding • signaling receptor binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • peptide receptor activity • thrombin-activated receptor activity • proteinase-activated receptor activity • G protein-coupled peptide receptor activity • G-protein beta-subunit binding • negative regulation of protein transport • regulation of systemic arterial blood pressure by renin-angiotensin • regulation of localization • multicellular organismal process • regulation of systemic arterial blood pressure by hormone • establishment of protein localization • system process • nitrogen compound transport • regulation of cellular process • regulation of renal system process • regulation of system process • negative regulation of biological process • negative regulation of transport • cell communication • localization • negative regulation of secretion • circulatory system process • renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of biological process • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • regulation of systemic arterial blood pressure by circulatory renin-angiotensin • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of endocrine process • renin secretion into blood stream • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of protein localization • transport • signaling • negative regulation of renin secretion into blood stream • protein localization to extracellular region • regulation of secretion by cell • secretion by cell • regulation of renin secretion into blood stream • signal release • negative regulation of cellular process • regulation of multicellular organismal process • renal system process involved in regulation of systemic arterial blood pressure • blood circulation • negative regulation of protein localization • renal system process • regulation of transport • secretion • regulation of blood pressure • biological regulation • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • endocrine process • regulation of systemic arterial blood pressure • protein transport • macromolecule localization • cellular process • multicellular organismal-level homeostasis • homeostatic process • homeostasis of number of cells within a tissue • anatomical structure homeostasis • tissue homeostasis • homeostasis of number of cells • regulation of tube diameter • regulation of tube size • positive regulation of biological process • positive regulation of vasoconstriction • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • blood vessel diameter maintenance • vasoconstriction • regulation of anatomical structure size • cellular response to stimulus • response to stimulus • thrombin-activated receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • apoptotic process • programmed cell death • positive regulation of cellular process • leukocyte homeostasis • immune system process • dendritic cell homeostasis • regulation of body fluid levels • wound healing • cell activation • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • platelet activation • positive regulation of interleukin-8 production • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • cytokine production • regulation of cytokine production • positive regulation of macromolecule metabolic process • regulation of biosynthetic process • interleukin-8 production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • positive regulation of gene expression • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • regulation of interleukin-8 production • phospholipase C-activating G protein-coupled receptor signaling pathway • regulation of calcium ion transport • positive regulation of calcium ion transport • regulation of monoatomic ion transport • calcium ion transport • metal ion transport • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • monoatomic cation transport • regulation of metal ion transport • positive regulation of coagulation • regulation of response to external stimulus • positive regulation of blood coagulation • regulation of response to wounding • regulation of coagulation • positive regulation of response to stimulus • regulation of response to stress • positive regulation of hemostasis • regulation of hemostasis • positive regulation of response to wounding • regulation of blood coagulation • response to external stimulus • positive regulation of wound healing • regulation of response to stimulus • regulation of wound healing • vesicle organization • cellular component organization • platelet dense granule organization • organelle organization • secretory granule organization • cellular component organization or biogenesis • endomembrane system organization • regulation of interleukin-1 production • interleukin-1 production • regulation of interleukin-1 beta production • interleukin-1 beta production • collagen biosynthetic process • regulation of collagen biosynthetic process • regulation of collagen metabolic process • positive regulation of collagen metabolic process • positive regulation of collagen biosynthetic process • collagen metabolic process • cell junction organization • neuromuscular junction development • establishment of synaptic specificity at neuromuscular junction • synapse organization • positive regulation of cytosolic calcium ion concentration • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of canonical NF-kappaB signal transduction • regulation of signal transduction • intracellular signal transduction • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of intracellular signal transduction • canonical NF-kappaB signal transduction • regulation of cell communication • regulation of canonical NF-kappaB signal transduction • positive regulation of signaling • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • interleukin-6 production • positive regulation of interleukin-6 production • regulation of interleukin-6 production • connective tissue replacement involved in inflammatory response wound healing • wound healing involved in inflammatory response • defense response • inflammatory response to wounding • tissue remodeling • connective tissue replacement • inflammatory response • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • positive regulation of small GTPase mediated signal transduction • trans-synaptic signaling • trans-synaptic signaling, modulating synaptic transmission • modulation of chemical synaptic transmission • trans-synaptic signaling by endocannabinoid • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • trans-synaptic signaling by lipid, modulating synaptic transmission • anterograde trans-synaptic signaling • trans-synaptic signaling by lipid • trans-synaptic signaling by endocannabinoid, modulating synaptic transmission • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • developmental process • anatomical structure morphogenesis • anatomical structure development • neuron apoptotic process • negative regulation of neuron apoptotic process • negative regulation of programmed cell death • negative regulation of apoptotic process • regulation of neuron apoptotic process • negative regulation of glomerular filtration • regulation of glomerular filtration • renal system process involved in regulation of blood volume • negative regulation of multicellular organismal process • glomerular filtration • renal filtration • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • negative regulation of cell population proliferation • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • cellular localization • inorganic ion homeostasis • intracellular calcium ion homeostasis • monoatomic ion transmembrane transport • calcium ion homeostasis • negative regulation of sequestering of calcium ion • maintenance of location in cell • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • regulation of sequestering of calcium ion • intracellular monoatomic ion homeostasis • calcium ion transmembrane import into cytosol • sequestering of calcium ion • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • cellular homeostasis • chemical homeostasis • calcium ion transmembrane transport • cell surface receptor signaling pathway via STAT • positive regulation of receptor signaling pathway via STAT • positive regulation of receptor signaling pathway via JAK-STAT • regulation of receptor signaling pathway via JAK-STAT • cell surface receptor signaling pathway • regulation of receptor signaling pathway via STAT • cell surface receptor signaling pathway via JAK-STAT • regulation of synaptic plasticity • positive regulation of DNA-templated transcription • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • primary metabolic process • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • positive regulation of smooth muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • smooth muscle contraction • regulation of muscle contraction • regulation of smooth muscle contraction • positive regulation of muscle contraction • cell junction maintenance • cellular component maintenance • cell-cell junction maintenance • cell-cell junction organization • positive regulation of cation transmembrane transport • positive regulation of monoatomic ion transmembrane transport • regulation of release of sequestered calcium ion into cytosol • regulation of transmembrane transport • regulation of monoatomic ion transmembrane transport • regulation of calcium ion transmembrane transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • positive regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic cation transmembrane transport • biological process involved in interspecies interaction between organisms • response to lipid • response to other organism • response to oxygen-containing compound • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to chemical • response to external biotic stimulus • response to molecule of bacterial origin • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • neuromuscular junction • Golgi apparatus • endomembrane system • cell surface • membrane microdomain • membrane raft • plasma membrane raft • caveola • early endosome • endosome • intracellular vesicle • cytoplasmic vesicle • platelet dense tubular network • late endosome • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25116
Sequence	>9D4Z_nogp_Chain_R S F L L R N A F I S E D A S G Y L T S S W L T L F V P S V Y T G V F V V S L P L N I M A I V V F I L K M K V K K P A V V Y M L H L A T A D V L F V S V L P F K I S Y Y F S G S D W Q F G S E L C R F V T A A F Y C N M Y A S I L L M T V I S I D R F L A V V Y P M Q S L S W R T L G R A S F T C L A I W A L A I A G V V P L L L K E Q T I Q V P G L N I T T C H D V L N E T L L E G Y Y A Y Y F S A F S A V F F F V P L I I S T V C Y V S I I R C L S S S A V A N R S K K S R A L F L S A A V F C I F I I C F G P T N V L L I A H Y S F L S H T S T T E A A Y F A Y L L C V C V S S I S C C I D P L I Y Y Y A S S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	3VW7	A	Peptide	Proteinase Activated	PAR1	Homo sapiens	-	Vorapaxar; Na	-	2.2	2012-12-12	doi.org/10.1038/nature11701
	8XOR	A	Peptide	Proteinase Activated	PAR1	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2024-09-18	doi.org/10.1038/s41422-024-00997-2
	8XOR (No Gprot)	A	Peptide	Proteinase Activated	PAR1	Homo sapiens	-	-		3	2024-09-18	doi.org/10.1038/s41422-024-00997-2
	8XOS	A	Peptide	Proteinase Activated	PAR1	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2024-09-18	doi.org/10.1038/s41422-024-00997-2
	8XOS (No Gprot)	A	Peptide	Proteinase Activated	PAR1	Homo sapiens	-	-		3.2	2024-09-18	doi.org/10.1038/s41422-024-00997-2
	9D4Z	A	Peptide	Proteinase Activated	PAR1	Homo sapiens	-	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.74	2025-05-07	doi.org/10.1038/s41467-025-59138-x
	9D4Z (No Gprot)	A	Peptide	Proteinase Activated	PAR1	Homo sapiens	-	-		2.74	2025-05-07	doi.org/10.1038/s41467-025-59138-x

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